WO2019070709A8 - Composés pour le traitement ou la prévention d'infections à flavivirus - Google Patents

Composés pour le traitement ou la prévention d'infections à flavivirus Download PDF

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WO2019070709A8
WO2019070709A8 PCT/US2018/053968 US2018053968W WO2019070709A8 WO 2019070709 A8 WO2019070709 A8 WO 2019070709A8 US 2018053968 W US2018053968 W US 2018053968W WO 2019070709 A8 WO2019070709 A8 WO 2019070709A8
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Prior art keywords
compounds
treating
flavivirus infections
preventing flavivirus
preventing
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PCT/US2018/053968
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WO2019070709A1 (fr
Inventor
Piotr Pawel RUCHALA
Ewa Dorota MICEMICZ
Ronil KHACHATOORIAN
Samuel Wheeler FRENCH
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The Regents Of The University Of California
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Publication of WO2019070709A1 publication Critical patent/WO2019070709A1/fr
Publication of WO2019070709A8 publication Critical patent/WO2019070709A8/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

La présente invention concerne des composés, des compositions et des procédés pour le traitement et/ou la prévention d'une infection à flavivirus par administration de tels composés et de telles compositions.
PCT/US2018/053968 2017-10-02 2018-10-02 Composés pour le traitement ou la prévention d'infections à flavivirus WO2019070709A1 (fr)

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US201762566667P 2017-10-02 2017-10-02
US201762566663P 2017-10-02 2017-10-02
US62/566,663 2017-10-02
US62/566,667 2017-10-02
US201762593787P 2017-12-01 2017-12-01
US62/593,787 2017-12-01

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WO2019070709A8 true WO2019070709A8 (fr) 2019-09-06

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CN110590708B (zh) * 2019-09-24 2021-08-17 中国医学科学院医药生物技术研究所 芳酰基哌嗪类化合物及其制备方法和在抗病毒中的应用

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WO2010073011A2 (fr) * 2008-12-23 2010-07-01 Betagenon Ab Composés utiles comme médicaments
WO2014164667A1 (fr) * 2013-03-11 2014-10-09 Georgetown University Inhibiteurs de protéases des virus west nile et de la dengue
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