WO2019058373A1 - DEVICE, ASSEMBLY AND METHOD OF DRESSING - Google Patents

DEVICE, ASSEMBLY AND METHOD OF DRESSING Download PDF

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Publication number
WO2019058373A1
WO2019058373A1 PCT/IL2018/051049 IL2018051049W WO2019058373A1 WO 2019058373 A1 WO2019058373 A1 WO 2019058373A1 IL 2018051049 W IL2018051049 W IL 2018051049W WO 2019058373 A1 WO2019058373 A1 WO 2019058373A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
wound
cavity
lips
clot
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2018/051049
Other languages
English (en)
French (fr)
Inventor
Alon Kushnir
Igal Kushnir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reddress Medical Ltd
Original Assignee
Reddress Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MX2020003158A priority Critical patent/MX2020003158A/es
Priority to JP2020516719A priority patent/JP7286178B2/ja
Priority to BR112020005723-1A priority patent/BR112020005723B1/pt
Priority to IL273406A priority patent/IL273406B2/en
Priority to CN201880073955.6A priority patent/CN111542290B/zh
Priority to KR1020207009725A priority patent/KR20200074945A/ko
Priority to AU2018338065A priority patent/AU2018338065B2/en
Priority to CA3077157A priority patent/CA3077157A1/en
Application filed by Reddress Medical Ltd filed Critical Reddress Medical Ltd
Priority to US16/649,809 priority patent/US20200306094A1/en
Priority to EP18785455.9A priority patent/EP3684313B1/en
Publication of WO2019058373A1 publication Critical patent/WO2019058373A1/en
Anticipated expiration legal-status Critical
Priority to ZA2020/04431A priority patent/ZA202004431B/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0203—Adhesive bandages or dressings with fluid retention members
    • A61F13/0226—Adhesive bandages or dressings with fluid retention members characterised by the support layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00987—Apparatus or processes for manufacturing non-adhesive dressings or bandages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/0017—Wound bandages possibility of applying fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00285—Wound bandages medication confinement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00365—Plasters use
    • A61F2013/00412—Plasters use for use with needles, tubes or catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00365—Plasters use
    • A61F2013/00412—Plasters use for use with needles, tubes or catheters
    • A61F2013/00417—Plasters use for use with needles, tubes or catheters pierced by needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A61F2013/00927—Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents

Definitions

  • This disclosure is in the field of wound treatment and concerns a wound dressing device, assembly and method.
  • US 9, 180,142 discloses a wound treatment procedure by which blood is coagulated and the so-formed blood clot is applied onto a wound with a dressing material.
  • the present disclosure concerns wound treatment through the use of a blood clot.
  • a wound dressing device and assembly e.g. in the form of a kit-of-parts for use in the currently disclosed wound treatment
  • a method for preparing a blood clot-comprising wound dressing e.g. in the form of a kit-of-parts for use in the currently disclosed wound treatment
  • a method for dressing the wound therewith e.g. in the form of a kit-of-parts for use in the currently disclosed wound treatment
  • the blood clot that is formed and used according to this disclosure is typically formed from blood of the same subject whose wound is to be dressed by the teaching of this disclosure, withdrawn from the subject in any manner acceptable in medical practice for blood withdrawal.
  • a different source e.g. blood obtained from a blood bank
  • blood obtained from a blood bank
  • one concerns a wound dressing device; the other concerns an assembly, e.g. in the form of a kit-of-parts, which comprises said device as one of its components; and the third concerns a method of wound dressing and a use wherein said device is a key component.
  • All three aspects center around the formation of a blood clot, in situ, onto a wound, as part of the wound dressing procedure. In other words, the blood, still in liquid state, is brought into contact with the wound and is induced to clot while at least partially in contact with the wound to be dressed therewith. All three aspects are encompassed in the following description by the term "wound dressing procedure" .
  • the method comprises fixing a device of the kind disclosed herein, on top of the wound, the device defining with the wound an enclosed space which serves as a mold (cast) for clotting blood on top of the wound.
  • This space will be referred to herein as a "mold space" .
  • the device comprises a cavity or depression surrounded by lips configured for attachment to skin in a fluid tight manner.
  • the cavity or depression may have walls that may be generally concave, polygonal or any other suitable shape.
  • the cavity is shallow, namely, it has a depth relatively smaller than the overall area confined by the walls.
  • the lips typically define narrow flat surfaces that when brought into contact with the skin, should be relatively level and smooth to permit fluid tight attachment to the skin.
  • the lips may carry an adhesive that will ensure fluid tight attachment to the skin.
  • the adhesive may be applied onto the skin or onto the lips, prior to attachment. At times, according to this embodiment, at least a portion of the lips may have a rough surface onto which the adhesive is applied prior to fixation onto the skin. It is also possible, by other embodiments of this disclosure, to fit a two-sided adhesive strip onto the lips or the skin to be used as means for attachment.
  • the attachment may be by means of an adhesive tape fitted over the device's lips and the surrounding skin portions for tight association throughout the blood clot formation process.
  • the attachment of the lips to the skin may be by forming a vacuum within the mold space, by forcing the device (and hence the lips) against the skin by hand, by the use of an elastic band, adhesive tape or other means for tight forcing of the device against the skin.
  • the wound's surface area confined between the lips may have different shapes and sizes to suit wounds of different shapes and sizes.
  • the wound dressing procedure may also involve selection of a device of the proper shape and size to permit the lips to be placed on skin portions surrounding the wound's boundaries.
  • the device is flexible or pliable to permit its shaping and/or stretching to a desired shape and wound surface area to be confined between the lips.
  • the device may also comprises a closure that is removably attached to the lips and seals the cavity until use.
  • the closure may be useful for maintaining sterility of the cavity and for holding elements, such as a coagulant initiator and/or scaffold matrix within the cavity.
  • the closure may, for example, be a film made of plastic, foil, a combination thereof, etc. that is pealed from the opening of the cavity (the lips) prior to fixation onto the skin. according to the wound dressing procedure disclosed herein, once the lips are firmly fixed to skin portions surrounding the wound, a mold space is formed, which, as noted above, is defined between the surface of the wound and the cavity's walls.
  • Blood typically whole blood
  • the blood clot is maintained over the wound for a time period. This time period may vary and is typically several hours, several days or several weeks, e.g. 1 day, 2-6 days, 1 week, 2-4 weeks, and at times even longer, as well as for any period of time in-between than that indicated.
  • the blood clot may be maintained over the wound for the entire healing process of several weeks to several month.
  • the wound treatment comprises periodical refreshing procedures that comprises removal of an existing blood clot from the wound and then forming a new blood clot on the wound in a manner as described above.
  • the time period between a blood clot formation over a wound and the performance of a refreshing procedure may be, for example, 1 day, 2-6 days, 1 week, 2-4 weeks, etc., as well as for any period of time in-between than that indicated.
  • the entire wound healing procedure may involve several consecutive refreshing procedures.
  • the device's walls may be made from a variety of materials. Typically, in order to permit monitoring the blood introduction and the clot formation, the walls or parts thereof are transparent. Introduction of the blood involves, by one embodiment, piercing the wall with a needle and then injecting blood into the mold space through the needle. Optionally, this introduction is preceded by a second piercing of the wall on an adjacent or different location, to thereby form a vent aperture to permit release of excess pressure during blood introduction.
  • the walls may comprise a venting valve which, a priori, is sealed and opened before the blood introduction and/or a port for introducing the blood into the mold space.
  • the device is removed after the blood clot is formed.
  • the walls are preferably made of or coated with a material to which a blood clot does not adhere.
  • the device or part thereof remains in situ after the blood clot is formed and serves as part of the wound dressing.
  • a dressing material for example, gauze, plaster or bandage
  • the wound dressing procedure may make use of a scaffold matrix combined with and brought into contact with the blood prior to its clotting, so as to become integrated with the thus formed blood clot.
  • the scaffold matrix supports the clot and assists in maintaining the clot's structural integrity.
  • the scaffold matrix may, by one embodiment, be an independent element fitted onto the wound, prior to said fixing of the device onto the skin; by another embodiment, the scaffold matrix may be comprised within the cavity, e.g. a priori comprised therein or introduced into the cavity before fixing the device onto the wound.
  • the scaffold matrix may, for example, be a 2-domesional or 3 -dimensional matrix, may be a porous material, may have a netlike structure; may be made of a polymeric material such as plastic, may be made out of natural or synthetic fibers or made out of a woven or non-woven cloth, e.g. gauze.
  • the blood may be contacted with one or combination of coagulation initiators, namely, one or more substances (synthetic or naturally occurring) that promotes/activates blood coagulation.
  • the coagulation initiator is kaolin.
  • coagulation of blood may involve, for example, mixing the blood with kaolin shortly before introduction into the mold space.
  • the coagulation initiator may a priori be present within the cavity; for example, attached to the walls or incorporated into a scaffold matrix, placed within or a priori comprised within the cavity or further, separately introduced into the mold space (e.g. by injection) before or after introduction of the blood.
  • the coagulation initiator may be incorporated into a scaffold matrix that is fitted onto the wound, prior to fixing of the device over the found.
  • the coagulation initiator is independently stored, e.g. as a powder, granulate or liquid in a separate container and subsequently mixed with the blood upon introduction into the mold space or applied onto the scaffold matrix prior to or after introducing the blood.
  • the coagulation initiator may be applied directly onto the wound as a first step in the wound treatment procedure.
  • the wound dressing assembly or kit of this disclosure comprises a clotting mold device of the kind specified above.
  • the assembly or kit may comprise other elements or devices required for the in situ formation of the blood clot on the wound, e.g. a syringe for introducing blood into the cavity.
  • the assembly or kit may comprise also a dressing material for applying over the blood clot formed over the wound.
  • Fig 1 shows a wound dressing device according to an embodiment of this disclosure.
  • Fig. 2 shows the wound dressing device after removal of the closure and applied onto the skin.
  • Figs. 3A and 3B show, respectively, two steps of introducing blood into the mold space.
  • Fig. 4 shows the wound dressing device with blood still in liquid form with the device secured by adhesive tape to the skin.
  • Fig. 5 shows the blood clot with the device partially ruptured prior to removal.
  • Fig. 6 shows the blood clot on the skin after its formation and after the device has been removed.
  • the device 100 shown in Fig. 1 includes generally concave walls 102 that form a cavity 104 defined between lips 106 that are generally flat.
  • the opening defined between the lips is sealed by a removable closure 108 which is a laminate/film fitted onto lips 106.
  • closure 108 After removal of closure 108, the device 100 is placed onto skin, an adhesive remaining after removal of the closure causes it to adhere to the skin.
  • a device 100 fixed to a subject's skin is shown in Fig. 2.
  • a scaffold matrix 112 placed within the cavity the scaffold matrix holds a coagulation initiator 110.
  • steps of introducing blood typically whole blood into the mold space are shown. Specifically, blood withdrawn from the subject or alternatively taken from a blood bank, is injected with a needle 120 into the mold space formed between the walls 102 and underlying portion of the skin or wound. According to this non-limiting embodiment, upon introduction into the mold space, the blood is mixed with the coagulation initiator 110 a priori present in the cavity. The needle 120 first pierces the walls of the device and then injects the blood contained in the syringe (not seen).
  • the blood is pre-mixed with a coagulation initiator, such as Kaolin, that is provided in a separate container (not shown), or the coagulation initiator is introduced into the mold space separately, either before, during or after the blood introduction.
  • a coagulation initiator such as Kaolin
  • the walls of the device are transparent to permit monitoring the introduction and subsequent blood clotting.
  • the device is then allowed to remain attached to the skin with the blood held within the mold space for a time at least until the blood has clotted. Such time may range from several days, to one or more weeks,
  • the device can be secured to the skin by use of an adhesive strip 130, as seen in Fig. 4.
  • a blood clot is formed and the walls of the device can then be cut away, as seen in Fig. 5; and, after removal, a blood clot 140 remains on top of the skin, as seen in Fig. 6.
  • the blood clot will cover the wound and a dressing material, which may be conventional dressing material, such as gauze or bandage, will be applied over the clot for protecting the wound and securing the clot in place.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Manufacturing & Machinery (AREA)
  • Anesthesiology (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
PCT/IL2018/051049 2017-09-24 2018-09-17 DEVICE, ASSEMBLY AND METHOD OF DRESSING Ceased WO2019058373A1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AU2018338065A AU2018338065B2 (en) 2017-09-24 2018-09-17 Wound dressing device, assembly and method
BR112020005723-1A BR112020005723B1 (pt) 2017-09-24 2018-09-17 Conjunto de curativo para ferimento
IL273406A IL273406B2 (en) 2017-09-24 2018-09-17 Wound Dressing Device, Assembly and Method
CN201880073955.6A CN111542290B (zh) 2017-09-24 2018-09-17 伤口包扎装置、组件及方法
KR1020207009725A KR20200074945A (ko) 2017-09-24 2018-09-17 상처 드레싱 장치, 어셈블리 및 방법
MX2020003158A MX2020003158A (es) 2017-09-24 2018-09-17 Dispositivo, conjunto y metodo de apositos para heridas.
EP18785455.9A EP3684313B1 (en) 2017-09-24 2018-09-17 Wound dressing device, assembly and method
CA3077157A CA3077157A1 (en) 2017-09-24 2018-09-17 Wound dressing device, assembly and method
US16/649,809 US20200306094A1 (en) 2017-09-24 2018-09-17 Wound dressing device, assembly and method
JP2020516719A JP7286178B2 (ja) 2017-09-24 2018-09-17 創傷ドレッシング器具、アセンブリおよび方法
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WO2021067340A1 (en) 2019-10-03 2021-04-08 Aatru Medical, LLC Reduced pressure device having selectively deliverable electrolyte
US11116884B2 (en) 2010-12-08 2021-09-14 Convatec Technologies Inc. Integrated system for assessing wound exudates
US11135315B2 (en) 2010-11-30 2021-10-05 Convatec Technologies Inc. Composition for detecting biofilms on viable tissues
WO2021205457A1 (en) * 2020-04-07 2021-10-14 Reddress Ltd. Blood extraction
US11241339B2 (en) 2011-11-29 2022-02-08 Convatec Inc. Perforated binder for laminated wound dressing
US11241525B2 (en) 2010-12-08 2022-02-08 Convatec Technologies Inc. Wound exudate monitor accessory
US11266774B2 (en) 2016-07-08 2022-03-08 Convatec Technologies Inc. Fluid collection apparatus
US11286601B2 (en) 2012-12-20 2022-03-29 Convatec Technologies, Inc. Processing of chemically modified cellulosic fibres
US11331221B2 (en) 2019-12-27 2022-05-17 Convatec Limited Negative pressure wound dressing
WO2022168099A1 (en) 2021-02-08 2022-08-11 Reddress Ltd. Method and kit for treating abnormal hollowed space
WO2022180627A1 (en) 2021-02-23 2022-09-01 Reddress Ltd. Kit for treating damaged nerves
US11452808B2 (en) 2016-07-08 2022-09-27 Convatec Technologies Inc. Fluid flow sensing
US11458044B2 (en) 2008-09-29 2022-10-04 Convatec Technologies Inc. Wound dressing
US11583430B2 (en) 2011-09-02 2023-02-21 Convatec Ltd. Skin contact material
US11596554B2 (en) 2016-07-08 2023-03-07 Convatec Technologies Inc. Flexible negative pressure system
WO2023037373A1 (en) 2021-09-13 2023-03-16 Reddress Ltd. Device for vaginal tissue treatment
US11628093B2 (en) 2008-05-08 2023-04-18 Convatec Technologies, Inc. Wound dressing
WO2023119274A1 (en) 2021-12-22 2023-06-29 Reddress Ltd. Method and kit for treating a damaged connective tissue
US11723808B2 (en) 2016-03-30 2023-08-15 Convatec Technologies Inc. Detecting microbial infections in wounds
US11740241B2 (en) 2016-03-30 2023-08-29 Synovo Gmbh Construct including an anchor, an enzyme recognition site and an indicator region for detecting microbial infection in wounds
US11771819B2 (en) 2019-12-27 2023-10-03 Convatec Limited Low profile filter devices suitable for use in negative pressure wound therapy systems
WO2024047650A1 (en) 2022-08-31 2024-03-07 Reddress Ltd. Method and system for treatment of bone or joint
WO2024084482A1 (en) 2022-10-18 2024-04-25 Reddress Ltd. Elements and system for wound treatment
US12076215B2 (en) 2019-06-03 2024-09-03 Convatec Limited Methods and devices to disrupt and contain pathogens
WO2024180534A1 (en) 2023-03-02 2024-09-06 Reddress Ltd. Method and kit for treating damaged connective tissue
US12121645B2 (en) 2010-12-08 2024-10-22 Convatec Technologies Inc. Method and system for removing exudates from a wound site
US12161792B2 (en) 2017-11-16 2024-12-10 Convatec Limited Fluid collection apparatus
US12290655B2 (en) 2015-10-21 2025-05-06 Convatec Limited Wound dressing
US12458540B2 (en) 2016-05-09 2025-11-04 Convatec Technologies Inc. Negative pressure wound dressing management system
WO2025243291A1 (en) 2024-05-19 2025-11-27 Reddress Ltd. Method and kit for treating a wound

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US11628093B2 (en) 2008-05-08 2023-04-18 Convatec Technologies, Inc. Wound dressing
US11458044B2 (en) 2008-09-29 2022-10-04 Convatec Technologies Inc. Wound dressing
US11135315B2 (en) 2010-11-30 2021-10-05 Convatec Technologies Inc. Composition for detecting biofilms on viable tissues
US11116884B2 (en) 2010-12-08 2021-09-14 Convatec Technologies Inc. Integrated system for assessing wound exudates
US11241525B2 (en) 2010-12-08 2022-02-08 Convatec Technologies Inc. Wound exudate monitor accessory
US12121645B2 (en) 2010-12-08 2024-10-22 Convatec Technologies Inc. Method and system for removing exudates from a wound site
US11583430B2 (en) 2011-09-02 2023-02-21 Convatec Ltd. Skin contact material
US11241339B2 (en) 2011-11-29 2022-02-08 Convatec Inc. Perforated binder for laminated wound dressing
US11286601B2 (en) 2012-12-20 2022-03-29 Convatec Technologies, Inc. Processing of chemically modified cellulosic fibres
US12290655B2 (en) 2015-10-21 2025-05-06 Convatec Limited Wound dressing
US11740241B2 (en) 2016-03-30 2023-08-29 Synovo Gmbh Construct including an anchor, an enzyme recognition site and an indicator region for detecting microbial infection in wounds
US11723808B2 (en) 2016-03-30 2023-08-15 Convatec Technologies Inc. Detecting microbial infections in wounds
US12458540B2 (en) 2016-05-09 2025-11-04 Convatec Technologies Inc. Negative pressure wound dressing management system
US11596554B2 (en) 2016-07-08 2023-03-07 Convatec Technologies Inc. Flexible negative pressure system
US11266774B2 (en) 2016-07-08 2022-03-08 Convatec Technologies Inc. Fluid collection apparatus
US11452808B2 (en) 2016-07-08 2022-09-27 Convatec Technologies Inc. Fluid flow sensing
US12161792B2 (en) 2017-11-16 2024-12-10 Convatec Limited Fluid collection apparatus
US12076215B2 (en) 2019-06-03 2024-09-03 Convatec Limited Methods and devices to disrupt and contain pathogens
WO2021067340A1 (en) 2019-10-03 2021-04-08 Aatru Medical, LLC Reduced pressure device having selectively deliverable electrolyte
EP4037723A4 (en) * 2019-10-03 2023-10-25 Aatru Medical, LLC Reduced pressure device having selectively deliverable electrolyte
US11331221B2 (en) 2019-12-27 2022-05-17 Convatec Limited Negative pressure wound dressing
US11771819B2 (en) 2019-12-27 2023-10-03 Convatec Limited Low profile filter devices suitable for use in negative pressure wound therapy systems
WO2021205457A1 (en) * 2020-04-07 2021-10-14 Reddress Ltd. Blood extraction
CN115397377B (zh) * 2020-04-07 2023-08-29 雷德助莱斯有限公司 血液提取
JP2023528146A (ja) * 2020-04-07 2023-07-04 レッドドレス リミテッド 血液抽出
JP7821115B2 (ja) 2020-04-07 2026-02-26 レッドドレス リミテッド 血液抽出
CN115397377A (zh) * 2020-04-07 2022-11-25 雷德助莱斯有限公司 血液提取
US12582743B2 (en) 2020-04-07 2026-03-24 Reddress Ltd. Blood extraction
WO2022168099A1 (en) 2021-02-08 2022-08-11 Reddress Ltd. Method and kit for treating abnormal hollowed space
WO2022180627A1 (en) 2021-02-23 2022-09-01 Reddress Ltd. Kit for treating damaged nerves
WO2023037373A1 (en) 2021-09-13 2023-03-16 Reddress Ltd. Device for vaginal tissue treatment
WO2023119274A1 (en) 2021-12-22 2023-06-29 Reddress Ltd. Method and kit for treating a damaged connective tissue
WO2024047650A1 (en) 2022-08-31 2024-03-07 Reddress Ltd. Method and system for treatment of bone or joint
WO2024084482A1 (en) 2022-10-18 2024-04-25 Reddress Ltd. Elements and system for wound treatment
WO2024180534A1 (en) 2023-03-02 2024-09-06 Reddress Ltd. Method and kit for treating damaged connective tissue
WO2025243291A1 (en) 2024-05-19 2025-11-27 Reddress Ltd. Method and kit for treating a wound

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US20200306094A1 (en) 2020-10-01
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AU2018338065B2 (en) 2023-11-02
CN111542290A (zh) 2020-08-14
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BR112020005723A2 (pt) 2020-10-20
CA3077157A1 (en) 2019-03-28

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