WO2019057920A1 - Nanogels réticulés d'ester de boronate basés sur des polysaccharides modifiés - Google Patents

Nanogels réticulés d'ester de boronate basés sur des polysaccharides modifiés Download PDF

Info

Publication number
WO2019057920A1
WO2019057920A1 PCT/EP2018/075652 EP2018075652W WO2019057920A1 WO 2019057920 A1 WO2019057920 A1 WO 2019057920A1 EP 2018075652 W EP2018075652 W EP 2018075652W WO 2019057920 A1 WO2019057920 A1 WO 2019057920A1
Authority
WO
WIPO (PCT)
Prior art keywords
nanogel
group
polysaccharide
modified
cis
Prior art date
Application number
PCT/EP2018/075652
Other languages
English (en)
Inventor
Rachel Auzely
Valérie Ravaine
Robin POIROT
Original Assignee
Centre National De La Recherche Scientifique (Cnrs)
Universite de Bordeaux
Institut Polytechnique De Bordeaux
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National De La Recherche Scientifique (Cnrs), Universite de Bordeaux, Institut Polytechnique De Bordeaux filed Critical Centre National De La Recherche Scientifique (Cnrs)
Publication of WO2019057920A1 publication Critical patent/WO2019057920A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/02—Dextran; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Inorganic Chemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Emergency Medicine (AREA)

Abstract

L'invention concerne un nanogel réticulé d'ester de boronate basé sur un mélange de : A) un polysaccharide anionique modifié greffé avec un groupe X, B) un polysaccharide neutre modifié greffé par un groupe Y, dans lequel : X est un dérivé d'acide arylboronique ou un dérivé de cis-diol, ledit cis-diol étant choisi dans le groupe constitué par le fructose, l'acide sialique, le maltose, le cellobiose et le lactose, Y est un dérivé d'acide arylboronique ou un dérivé de cis-diol, ledit cis-diol étant choisi dans le groupe constitué par le fructose, l'acide sialique, le maltose, le cellobiose et le lactose, si l'un de X ou Y est un dérivé d'acide arylboronique, l'autre est un dérivé de cis-diol.
PCT/EP2018/075652 2017-09-22 2018-09-21 Nanogels réticulés d'ester de boronate basés sur des polysaccharides modifiés WO2019057920A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17306251.4 2017-09-22
EP17306251 2017-09-22

Publications (1)

Publication Number Publication Date
WO2019057920A1 true WO2019057920A1 (fr) 2019-03-28

Family

ID=60083228

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2018/075652 WO2019057920A1 (fr) 2017-09-22 2018-09-21 Nanogels réticulés d'ester de boronate basés sur des polysaccharides modifiés

Country Status (1)

Country Link
WO (1) WO2019057920A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110433330A (zh) * 2019-09-19 2019-11-12 重庆大学 一种钛基活性骨植入体及其制备方法
CN112641951A (zh) * 2020-12-18 2021-04-13 河南工业大学 一种生物活性超分子手性水凝胶及其制备方法与应用
CN114681661A (zh) * 2022-03-28 2022-07-01 四川大学 一种止血粉及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110257033A1 (en) * 2010-04-19 2011-10-20 Strano Michael S Polymer-nanostructure composition for selective molecular recognition
WO2012066133A1 (fr) 2010-11-18 2012-05-24 Centre National De La Recherche Scientifique (Cnrs) Derives de polysaccharides comprenant un motif alcene et reaction de couplage par chimie thio-clic
WO2014072330A1 (fr) 2012-11-06 2014-05-15 Centre National De La Recherche Scientifique (Cnrs) Hydrogel réagissant au glucose comprenant l'acide hyaluronique (ha) sur lequel est greffé pba

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110257033A1 (en) * 2010-04-19 2011-10-20 Strano Michael S Polymer-nanostructure composition for selective molecular recognition
WO2012066133A1 (fr) 2010-11-18 2012-05-24 Centre National De La Recherche Scientifique (Cnrs) Derives de polysaccharides comprenant un motif alcene et reaction de couplage par chimie thio-clic
WO2014072330A1 (fr) 2012-11-06 2014-05-15 Centre National De La Recherche Scientifique (Cnrs) Hydrogel réagissant au glucose comprenant l'acide hyaluronique (ha) sur lequel est greffé pba

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JUAN LI ET AL: "pH and glucose dually responsive injectable hydrogel prepared by in situ crosslinking of phenylboronic modified chitosan and oxidized dextran", JOURNAL OF POLYMER SCIENCE, PART A: POLYMER CHEMISTRY, vol. 53, no. 10, 15 May 2015 (2015-05-15), pages 1235 - 1244, XP055455932, ISSN: 0887-624X, DOI: 10.1002/pola.27556 *
MERGY, J.; FOURNIER, A.; HACHET, E.; AUZELY-VELTY, R.: "Modification of Polysaccharides Via Thiol-Ene Chemistry: A Versatile Route to Functional Biomaterials", J. POLYM. SCI., PART A POLYM. CHEM., vol. 50, 2012, pages 4019 - 4028
NOBBMANN, U.; MORFESIS, A.: "Light scattering and nanoparticles", MATERIALS TODAY, vol. 12, 2009, pages 52 - 54, XP026139268, DOI: doi:10.1016/S1369-7021(09)70164-6
TARUS, D.; HACHET, E.; MESSAGER, L.; CATARGI, B.; RAVAINE, V.; AUZELY-VELTY, R.: "Readily Prepared Dynamic Hydrogels by Combining Phenyl Boronic Acid- and Maltose-Modified Anionic Polysaccharides at Neutral Ph.", MACROMOL. RAPID COMMUN., vol. 35, 2014, pages 2089 - 2095, XP055440663, DOI: doi:10.1002/marc.201400477

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110433330A (zh) * 2019-09-19 2019-11-12 重庆大学 一种钛基活性骨植入体及其制备方法
CN110433330B (zh) * 2019-09-19 2021-11-09 重庆大学 一种钛基活性骨植入体及其制备方法
CN112641951A (zh) * 2020-12-18 2021-04-13 河南工业大学 一种生物活性超分子手性水凝胶及其制备方法与应用
CN114681661A (zh) * 2022-03-28 2022-07-01 四川大学 一种止血粉及其制备方法

Similar Documents

Publication Publication Date Title
Teng et al. Recent development of alginate-based materials and their versatile functions in biomedicine, flexible electronics, and environmental uses
US6525145B2 (en) Polylactide/dextran graft co-polymers for biomaterial and tissue engineering applications
Kim et al. Natural and synthetic biomaterials for controlled drug delivery
Banks et al. Chemical modification of alginate for controlled oral drug delivery
US9549987B2 (en) Glucose responsive hydrogel comprising PBA-grafted hyaluronic acid (HA)
Gil et al. Injectable hydrogel-incorporated cancer cell-specific cisplatin releasing nanogels for targeted drug delivery
Wong Alginate graft copolymers and alginate–co-excipient physical mixture in oral drug delivery
Nejati et al. Development of an oxygen-releasing electroconductive in-situ crosslinkable hydrogel based on oxidized pectin and grafted gelatin for tissue engineering applications
Zheng et al. Chitosan-g-MPEG-modified alginate/chitosan hydrogel microcapsules: A quantitative study of the effect of polymer architecture on the resistance to protein adsorption
Mihajlovic et al. Hyaluronic acid-based supramolecular hydrogels for biomedical applications
WO2019057920A1 (fr) Nanogels réticulés d'ester de boronate basés sur des polysaccharides modifiés
JP2002527408A (ja) ドラッグデリバリー用ヒドロゲル及び水溶性ポリマーキャリアー
US7348424B2 (en) Polysaccharide containing phosphorylcholine group and process for producing the same
CN1954817A (zh) 一种可注射型pH及葡萄糖敏感水凝胶的制备方法
Liu et al. Self-assembly of cationic amphiphilic cellulose-g-poly (p-dioxanone) copolymers
Li et al. Supramolecular polymers based on cyclodextrins for drug and gene delivery
CN115400071A (zh) 负载非水溶性眼内药物控释的可注射水凝胶及其制备方法
Sarmah et al. Self-cross-linked starch/chitosan hydrogel as a biocompatible vehicle for controlled release of drug
CN113599507A (zh) 葡萄糖触发的活性氧响应注射型复合水凝胶的制备方法
CN107325300B (zh) 一种pH敏感水凝胶及其制备和应用
Dubashynskaya et al. Hyaluronan-colistin conjugates: Synthesis, characterization, and prospects for medical applications
Kim et al. Recent studies on modulating hyaluronic acid-based hydrogels for controlled drug delivery
Biswas et al. Biomedical applications carboxymethyl chitosans
Chatterjee et al. Cationic starch: A functionalized polysaccharide based polymer for advancement of drug delivery and health care system-A review
CN107595767A (zh) 一种拥有对电刺激和pH双重响应性能的抗菌可注射水凝胶及其制备方法和应用

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18772808

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18772808

Country of ref document: EP

Kind code of ref document: A1