WO2019054565A1 - Suture biodégradable ayant des éléments de retenue et son procédé de production - Google Patents

Suture biodégradable ayant des éléments de retenue et son procédé de production Download PDF

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Publication number
WO2019054565A1
WO2019054565A1 PCT/KR2017/013637 KR2017013637W WO2019054565A1 WO 2019054565 A1 WO2019054565 A1 WO 2019054565A1 KR 2017013637 W KR2017013637 W KR 2017013637W WO 2019054565 A1 WO2019054565 A1 WO 2019054565A1
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WO
WIPO (PCT)
Prior art keywords
retainer
suture
suture body
biodegradable
retainers
Prior art date
Application number
PCT/KR2017/013637
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English (en)
Korean (ko)
Inventor
유재원
신미향
Original Assignee
21세기메디칼 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 21세기메디칼 주식회사 filed Critical 21세기메디칼 주식회사
Publication of WO2019054565A1 publication Critical patent/WO2019054565A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/14—Post-treatment to improve physical properties
    • D—TEXTILES; PAPER
    • D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
    • D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
    • D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
    • D02G3/44—Yarns or threads characterised by the purpose for which they are designed
    • D—TEXTILES; PAPER
    • D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
    • D02J—FINISHING OR DRESSING OF FILAMENTS, YARNS, THREADS, CORDS, ROPES OR THE LIKE
    • D02J3/00—Modifying the surface
    • D02J3/02—Modifying the surface by abrading, scraping, scuffing, cutting, or nicking

Definitions

  • the present invention relates to a biodegradable suture having a retainer and a method for producing the same. More particularly, the present invention relates to a biodegradable suture which can securely fix a suture inserted into a human body through a retainer structure to a body tissue as a plurality of separately manufactured retainers are inserted in the longitudinal direction of the suture and fixed to the suture, And a manufacturing method thereof.
  • Facial laparoscopic surgery is a procedure to make the suture support the skin by inserting the suture under the facial skin and then pulling the suture. This method is widely used in recent years due to its advantages such as no need for skin incision, short treatment time and recovery period It is a procedure.
  • Korean Patent No. 10-1642962 discloses a method of forming a barb on the surface of a suture by pressing a suture using a mold.
  • the suture in order to pressurize the suture to form a barbed shape, the suture must be heated to facilitate deformation, so that the quality of the suture is deteriorated due to damage or unexpected deformation of the suture due to heat.
  • An embodiment of a method of manufacturing a biodegradable suture having a retainer includes the steps of providing a biodegradable suture material body formed to be long in the longitudinal direction, preparing an insertion hole through a central portion of a plurality of biodegradable retainers, Inserting the suture body into the suture body and disposing the suture body apart from each other along the outer circumferential surface of the suture body, and fixing the retainer to the outer circumferential surface of the suture body.
  • the method may further include the step of providing the retainer in a cone shape.
  • fixation of the retainer and the suture body may be performed by heat-pressing the retainer at a temperature below the melting point.
  • fixation of the retainer and the suture body may be performed by pressing the retainer and the suture body with a non-heated press apparatus.
  • suture body and the retainer may be made of polydioxanone material.
  • the retainer may be formed by forming a plurality of cone shapes by pressing the outer peripheral surface of the suture yarn and cutting each of the cone shapes.
  • it may include a step of coating a surface of the suture body and the retainer with a lysosome-derived enzyme.
  • the method may further include aligning the tip portion of the cone shape of the retainer in the center direction so as to be symmetrical about the center portion of the suture body.
  • the method may further include aligning the tip portions on the cone-shaped portion of the retainer to face each other about any one portion of the suture body.
  • One embodiment of a biodegradable suture with a retainer may be manufactured and provided in the manner described above.
  • the retainer fixed to the internal tissue can be formed on the suture without being heated at high temperature to prevent deterioration in the quality of the suture, .
  • the retainer of the suture can be provided in a cone shape in which the tip portions are opposed to each other, thereby maximizing the tissue fixation force.
  • FIG. 1 is a side view showing a biodegradable suture having a retainer according to an embodiment of the present invention.
  • FIG. 2 is a conceptual view illustrating a process of forming a part of a biodegradable suture having a retainer according to an embodiment of the present invention.
  • FIG 3 is a side view showing a biodegradable suture having a retainer according to another embodiment of the present invention.
  • FIG. 1 is a side view showing a biodegradable suture having a retainer according to an embodiment of the present invention
  • FIG. 2 is a conceptual view showing a process of forming a part of a biodegradable suture having a retainer according to an embodiment of the present invention
  • Fig. 3 is a side view showing a biodegradable suture having a retainer according to another embodiment of the present invention.
  • the biodegradable suture 10 is composed of a suture body 100 and a retainer 200.
  • the suture body 100 In the step of preparing the suture body 100, the suture body 100, which is long in the longitudinal direction, is cut to a proper length.
  • the suture body 100 is formed of a biodegradable material used for sewing, ligation and fixing of a human body tissue.
  • the suture body 100 may be made of a biodegradable polymer compound such as polydioxanone, polycaprolactone, polyglycine, polyglycolic acid, and polyglyconate, And copolymers thereof, and the like.
  • the biodegradable suture body 100 may be inserted into the body and biodegraded and absorbed into the body, so that the incised body 100 can be used as a lifting chamber for sealing or inserting the tissue.
  • the suture body 100 formed in the longitudinal direction is inserted into the body through a needle or an injector and is not fixed in the body, the suture body 100 is directly pulled out of the suture body 100 with the incision formed for injection of the suture body 100 It is difficult to use for purposes such as suturing or inserting the tissue.
  • the retainer 200 is formed on the suture body 100, so that the structure of the retainer 200 and the structure of the body are fixed, so that the suture body 100 can be fixed in the body.
  • the step of forming the insertion hole in the retainer 200 is carried out through the center of the retainer 200 of the biodegradable material.
  • the retainer 200 may be formed of the same material as the suture body 100 and the material of the retainer 200 may be selected from the group consisting of Polydioxanone, PolyCaprolactone, Polyglactin, Poly Polymeric compounds having biodegradability such as polyglycolic acid and polyglyconate, and copolymers thereof, and the like.
  • the insertion holes of the retainer 200 can be formed by hollowing the central portion of each retainer 200 with a needle or a laser.
  • the retainer 200 may be provided with a plurality of pre-manufactured retainers 200 and may be inserted into the suture body 100. Alternatively, the retainer 200 may be directly manufactured by processing the suture yarn 500. [ The process of separately manufacturing the retainer 200 will be described later.
  • the retainer 200 is inserted into the end of the suture material body 100 such that a plurality of retainers 200 are inserted along the outer circumferential surface of the suture material body 100 so that the inserted retainers 200 are spaced apart from each other have. Adjusting the number and distance of the retainers (200) inserted into the suture body (100), the fixing force of the body tissue and the biodegradable suture (10) can be adjusted.
  • the step of inserting and inserting the retainer 200 into the outer peripheral surface of the suture body 100 may be performed in various forms.
  • the step of arranging the cone-shaped retainer 200 inserted into the suture body 100 to be symmetrical about the center of the suture body 100 may be performed (FIG. 2A). More specifically, the cone-shaped tip portion of one retainer 200 is disposed so as to face the central portion of the suture body 100 with respect to the center of the suture body 100, and the tip portion of the cone- And may be symmetrically formed with respect to the center of the suture body 100 by arranging the suture body 100 toward the center of the body 100.
  • the cone-shaped retainer 200 inserted into the suture body 100 is aligned so that the retainers 200 on both sides face each other with respect to a part of the suture body 100 that is not the center of the suture body 100 (Fig. 2B). More specifically, the tip portion of the retainer 200 disposed on one side with respect to a certain portion of the suture body 100 is disposed toward the reference portion, and the tip portion of the retainer 200 disposed on the other side is also a reference And may be arranged so as to be opposed to each other with respect to a specific portion of the suture body 100.
  • the tip portion of the retainer 200 When the tip portion of the retainer 200 is disposed to face the central portion or a specific portion of the suture body 100, the binding force with the internal structure of the retainer 200 is structurally increased more than the tip portion of the retainer 200 is disposed only in the specific direction . Therefore, the biodegradable suture 10 having the structure in which the tip portion of the retainer 200 is opposed is used as a lifting chamber for facial elevation, and the skin tissue is strongly pulled, thereby maximizing the wrinkle reduction effect. By adjusting the arrangement and the number of the retainers 200, it is possible to manufacture a suture having different characteristics according to the characteristics of the skin tissue.
  • the retainer 200 inserted into the suture body 100 needs to be fixed to the suture body 100 so that the retainer 200 inserted into the suture body 100 is not separated from the suture body 100. Therefore, .
  • Fixation of the suture body 100 and the retainer 200 may be implemented in various forms.
  • the retainer 200 and the suture body 100 may be deformed and fixed with a pressing press 600 to be described later. In this case, it is easy to maintain the structure of the retainer 200 in the suture body 100 because the retainer 200 is not thermally deformed.
  • the retainer 200 inserted into the outer surface of the suture body 100 may be heated and compressed at a temperature below the melting point to fix the suture body 100 and the retainer 200.
  • the retainer 200 is heated at a temperature below the melting point, but a portion of the retainer 200 which is in contact with the suture body 100 due to the pressure due to being pressed together with the heat may be partially melted and fixedly engaged with the suture body 100.
  • the heating and pressing of the retainer 200 may be performed by a separate heating press (not shown) or the like.
  • the suture body 100 and the retainer 200 may be attached to each other using a biocompatible adhesive that is less reactive with the living body.
  • the step of providing the retainer 200 in a cone shape having a tip portion may be performed before the step of forming the insertion hole in the retainer 200.
  • the tip portion may be an end portion having the narrowest width in the retainer 200 having a conical shape or a conical shape.
  • a configuration in which a plurality of retainers 200 having a cone shape are inserted into the suture material body 100 can be formed as shown in FIG.
  • the retainer 200 may be formed of polygonal horns in addition to the cone shape.
  • a step of coating a surface of the suture body 100 or the retainer 200 with a lysosome-derived enzyme may be further performed.
  • the surface of the suture body 100 or the retainer 200 may be coated with a lysosome-derived enzyme extracted from egg white such as eggs of poultry.
  • a lysosome-derived enzyme extracted from egg white such as eggs of poultry.
  • the retainer 200 may be manufactured by separately pressing the stitched yarn 500.
  • the suture yarn 500 is a raw material for manufacturing the suture body 100, and may be formed of the same biodegradable polymeric compound as the suture body 100 and a copolymer thereof.
  • the suture yarn 500 may be used as the suture body 100 itself or may be pressed through a pressure roller (not shown) to reduce the thickness thereof so that the suture body 100 can be used.
  • the retainer 200 may be manufactured by processing the suture yarn 500 and then inserted into the suture body 100.
  • the unprocessed suture yarn 500 is heated to a temperature below the melting point through a heating device (not shown) to facilitate processing (Fig. 3A).
  • the heating device can be heated to a temperature of about 55-60 DEG C or less when the suture yarn 500 is made of a polycaprolactone material, and when the suture yarn 500 is formed of a polydioxanone material And can be heated to a temperature of about 50 ° C or less.
  • the heating of the stitched yarn 500 may not be performed in accordance with the molding press 300. That is, when the molding press 300 is provided to perform non-heating pressurization, the heating device, the heating process, and the like may be omitted.
  • the suture yarn 500 is pressed on both sides of the sewing yarn 500 by a molding press 300 having a plurality of cone-shaped molds (Fig. 3B).
  • a plurality of cone shapes are formed on the outer circumferential surface of the pressurized suture yarn 500.
  • the shape of the cone is separated using the cutting tool 400 to manufacture the respective retainers 200 ( Figure 3c).
  • the cutting tool 400 may be a sharp-tipped cutter, but various cutting tools such as a laser may be used.
  • the cut cone-shaped retainer 200 is inserted into the suture body 100 to dispose the retainer 200 (FIG. 3D). Thereafter, the retainer 200 and the suture body 100 are pressed and fixed using a non-heating press 600 without heating (FIG. 3E).
  • the fixing of the retainer 200 and the suture body 100 may be performed by using a non-heating press 600 or by heating and pressing at a temperature below the melting point of the suture body 100 or the retainer 200, Or may be attached with a biocompatible adhesive with low reactivity.
  • the retainer of the suture can be provided in a cone shape in which the tip portions are opposed to each other, thereby maximizing the tissue fixation force.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Textile Engineering (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne : une suture biodégradable dans laquelle une pluralité d'éléments de retenue produits séparément sont insérés dans la direction longitudinale de la suture à fixer à la suture, de telle sorte que la suture insérée dans un corps humain peut maintenir de manière plus sûre un tissu corporel à travers une structure de retenue ; et son procédé de production. Un mode de réalisation du procédé de production d'une suture biodégradable ayant des éléments de retenue peut comprendre : une étape consistant à fournir un corps de suture biodégradable formé pour être long dans la direction longitudinale ; une étape consistant à fournir des trous d'insertion par pénétration d'une partie centrale d'une pluralité d'éléments de retenue faits d'un matériau biodégradable ; une étape consistant à agencer les éléments de retenue espacés les uns des autres le long de la surface périphérique externe d'un corps de suture par insertion des éléments de retenue dans le corps de suture ; et une étape consistant à fixer les éléments de retenue à la surface périphérique externe du corps de suture.
PCT/KR2017/013637 2017-09-18 2017-11-28 Suture biodégradable ayant des éléments de retenue et son procédé de production WO2019054565A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0119818 2017-09-18
KR1020170119818A KR20190031859A (ko) 2017-09-18 2017-09-18 리테이너를 갖는 생분해성 봉합사 및 그의 제조방법

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111110399A (zh) * 2019-12-09 2020-05-08 先健科技(深圳)有限公司 植入式器械

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090035692A (ko) * 2006-08-07 2009-04-10 실루엣 리프트 소시에타드 리미타다 상처봉합, 조직밀착, 조직지지, 부유 및/또는 고정을 위한 봉합사
US20100160961A1 (en) * 2008-12-22 2010-06-24 Ethicon, Inc. Surgical sutures having collapsible tissue anchoring protrusions and methods therefor
KR20110003532A (ko) * 2008-04-15 2011-01-12 안지오테크 파마슈티칼즈, 인코포레이티드 이-방향성 유지장치 또는 단일-방향성 유지장치를 갖는 자가-유지 봉합사
KR101701434B1 (ko) * 2015-11-18 2017-02-13 정영춘 신규 안면 및 신체 리프팅용 봉합사
KR20170044454A (ko) * 2015-10-15 2017-04-25 박래경 돌기를 가진 매선로프 제조장치

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090035692A (ko) * 2006-08-07 2009-04-10 실루엣 리프트 소시에타드 리미타다 상처봉합, 조직밀착, 조직지지, 부유 및/또는 고정을 위한 봉합사
KR20110003532A (ko) * 2008-04-15 2011-01-12 안지오테크 파마슈티칼즈, 인코포레이티드 이-방향성 유지장치 또는 단일-방향성 유지장치를 갖는 자가-유지 봉합사
US20100160961A1 (en) * 2008-12-22 2010-06-24 Ethicon, Inc. Surgical sutures having collapsible tissue anchoring protrusions and methods therefor
KR20170044454A (ko) * 2015-10-15 2017-04-25 박래경 돌기를 가진 매선로프 제조장치
KR101701434B1 (ko) * 2015-11-18 2017-02-13 정영춘 신규 안면 및 신체 리프팅용 봉합사

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111110399A (zh) * 2019-12-09 2020-05-08 先健科技(深圳)有限公司 植入式器械

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