WO2019051750A1 - 一种聚乙二醇改性壳聚糖膜的制备方法 - Google Patents

一种聚乙二醇改性壳聚糖膜的制备方法 Download PDF

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WO2019051750A1
WO2019051750A1 PCT/CN2017/101828 CN2017101828W WO2019051750A1 WO 2019051750 A1 WO2019051750 A1 WO 2019051750A1 CN 2017101828 W CN2017101828 W CN 2017101828W WO 2019051750 A1 WO2019051750 A1 WO 2019051750A1
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parts
polyethylene glycol
solution
film
preparation
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PCT/CN2017/101828
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English (en)
French (fr)
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谭玲
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谭玲
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Definitions

  • the invention relates to a preparation method of a polyethylene glycol modified chitosan film.
  • Chitosan is the only polymeric compound with cations in nature. It has unique biological activity to promote cell growth and good histocompatibility to cells. More importantly, it has a broad-spectrum antibacterial effect. These properties make it It becomes an excellent mask substrate. Since chitosan is insoluble in water and common organic solvents, it limits its application range, but it can be modified to expand its application range.
  • Polyethylene glycol has good biocompatibility and is one of the new materials for chitosan modification. Polyethylene glycol also has good film-forming properties, and the formed film is very good. Flexibility. The results show that the hydrogel formed by the reaction of chitosan and polyethylene glycol can help to quickly repair skin wounds or defects, and provides a new idea for the development of green, safe and efficient biomimetic membrane technology.
  • a preparation method of a polyethylene glycol modified chitosan film comprising the steps of: dissolving 15-25 parts of chitosan powder in 30-40 parts by mass of 1% formic acid solution, and then adding 10-20 Part of polyethylene glycol, stirring at room temperature for 1-3h; the above mixed solution is dried at 40-50 ° C for 16-20h, the solution is solidified into a gel-like film; after drying, the film is immersed in 2% potassium hydroxide The solution was peeled off and washed with deionized water for 3-5 times, and air-dried at room temperature; each raw material was in parts by weight.
  • chitosan powder is dissolved in 35 parts by mass of a 1% formic acid solution.
  • the preparation method it is stirred at room temperature for 2 hours.
  • the mixed solution is dried at 45 ° C for 18 h.
  • the preparation method it is washed 4 times with deionized water.
  • the method provided by the invention is simple and easy to operate, and the polyethylene glycol modified chitosan film can be obtained, and the adsorption effect is excellent.
  • a preparation method of a polyethylene glycol modified chitosan film comprising the steps of: dissolving 20 parts of chitosan powder in 35 parts In a 1% formic acid solution, 15 parts of polyethylene glycol was added, and the mixture was stirred at room temperature for 2 hours; the mixed solution was dried at 45 ° C for 18 hours to cure the solution into a gelatinous film; after drying, the film was dried.
  • the product was immersed in a 2% potassium hydroxide solution and stripped, and washed 4 times with deionized water, and air-dried at room temperature; each raw material was in parts by weight.
  • a preparation method of a polyethylene glycol modified chitosan film comprising the steps of: dissolving 15 parts of chitosan powder in 30 parts by mass of 1% formic acid solution, and then adding 10 parts of polyethylene glycol; Stir at room temperature for 1 h; the above mixed solution was dried at 40 ° C for 16 h to solidify the solution into a gelatinous film; after drying, the film was immersed in 2% potassium hydroxide solution and stripped, and washed with deionized water 3 times. It is air-dried at room temperature; each raw material is in parts by weight.
  • a preparation method of a polyethylene glycol modified chitosan film comprises the steps of: dissolving 25 parts of chitosan powder in 40 parts by mass of 1% formic acid solution, and then adding 20 parts of polyethylene glycol, Stir at room temperature for 3 h; the above mixed solution was dried at 50 ° C for 20 h to solidify the solution into a gelatinous film; after drying, the film was immersed in 2% potassium hydroxide solution and stripped, and washed with deionized water 5 times. It is air-dried at room temperature; each raw material is in parts by weight.
  • the method provided by the invention is simple and easy to operate, and the polyethylene glycol modified chitosan film can be obtained, and the adsorption effect is excellent.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

本申请公开了一种聚乙二醇改性壳聚糖膜的制备方法，包括如下步骤：将15-25份壳聚糖粉末溶于30-40份质量分数为1%的甲酸溶液中，再加入10-20份聚乙二醇，室温下搅拌1-3h；将上述混合溶液在40-50℃下干燥16-20h，使溶液固化为凝胶状膜质；干燥后，将膜质浸入2%氢氧化钾溶液中剥离，并用去离子水洗涤3-5次，室温风干即得；各原料均为重量份。本申请提供的方法简便、易操作，可以得到聚乙二醇改性的壳聚糖膜，且吸附效果优异。

Description

一种聚乙二醇改性壳聚糖膜的制备方法 技术领域
本发明涉及一种聚乙二醇改性壳聚糖膜的制备方法。
背景技术
壳聚搪是自然界中唯一的带阳离子的高分子化合物，具有促进细胞生长的独特生物活性及对细胞良好的组织相容性，更为重要的是它具有广谱的抗菌的作用，这些性质使它成为一种优异的面膜基材。由于壳聚糖不溶于水和普通有机溶剂，因此限制了其应用范围，但是可以通过改性来扩大其应用范围。
聚乙二醇具有很好的生物相容性，是一种新型的用于壳聚糖改性的材料之一，并且聚乙二醇同时具有很好的成膜性能，形成的薄膜有很好的柔韧性。研究结果表明，壳聚糖和聚乙二醇反应形成的水凝胶有助于快速修复皮肤伤口或缺陷，为绿色、安全、高效的仿生膜技术开发提供了新的思路。
发明内容
本发明的目的在于提供一种聚乙二醇改性壳聚糖膜的制备方法。
本发明通过下面技术方案实现：
一种聚乙二醇改性壳聚糖膜的制备方法，包括如下步骤：将15-25份壳聚糖粉末溶于30-40份质量分数为1％的甲酸溶液中，再加入10-20份聚乙二醇，室温下搅拌1-3h；将上述混合溶液在40-50℃下干燥16-20h，使溶液固化为凝胶状膜质；干燥后，将膜质浸入2％氢氧化钾溶液中剥离，并用去离子水洗涤3-5次，室温风干即得；各原料均为重量份。
优选地，所述的制备方法中，将20份壳聚糖粉末溶于35份质量分数为1％的甲酸溶液。
优选地，所述的制备方法中，加入15份聚乙二醇。
优选地，所述的制备方法中，室温下搅拌2h。
优选地，所述的制备方法中，将混合溶液在45℃下干燥18h。
优选地，所述的制备方法中，用去离子水洗涤4次。
本发明技术效果：
本发明提供的方法简便、易操作，可以得到聚乙二醇改性的壳聚糖膜，且吸附效果优异。
具体实施方式
下面结合实施例具体介绍本发明的实质性内容。
实施例1
一种聚乙二醇改性壳聚糖膜的制备方法，包括如下步骤：将20份壳聚糖粉末溶于35份 质量分数为1％的甲酸溶液中，再加入15份聚乙二醇，室温下搅拌2h；将上述混合溶液在45℃下干燥18h，使溶液固化为凝胶状膜质；干燥后，将膜质浸入2％氢氧化钾溶液中剥离，并用去离子水洗涤4次，室温风干即得；各原料均为重量份。
实施例2
一种聚乙二醇改性壳聚糖膜的制备方法，包括如下步骤：将15份壳聚糖粉末溶于30份质量分数为1％的甲酸溶液中，再加入10份聚乙二醇，室温下搅拌1h；将上述混合溶液在40℃下干燥16h，使溶液固化为凝胶状膜质；干燥后，将膜质浸入2％氢氧化钾溶液中剥离，并用去离子水洗涤3次，室温风干即得；各原料均为重量份。
实施例3
一种聚乙二醇改性壳聚糖膜的制备方法，包括如下步骤：将25份壳聚糖粉末溶于40份质量分数为1％的甲酸溶液中，再加入20份聚乙二醇，室温下搅拌3h；将上述混合溶液在50℃下干燥20h，使溶液固化为凝胶状膜质；干燥后，将膜质浸入2％氢氧化钾溶液中剥离，并用去离子水洗涤5次，室温风干即得；各原料均为重量份。
本发明提供的方法简便、易操作，可以得到聚乙二醇改性的壳聚糖膜，且吸附效果优异。

Claims (6)

  1. 一种聚乙二醇改性壳聚糖膜的制备方法，其特征在于包括如下步骤：将15-25份壳聚糖粉末溶于30-40份质量分数为1％的甲酸溶液中，再加入10-20份聚乙二醇，室温下搅拌1-3h；将上述混合溶液在40-50℃下干燥16-20h，使溶液固化为凝胶状膜质；干燥后，将膜质浸入2％氢氧化钾溶液中剥离，并用去离子水洗涤3-5次，室温风干即得；各原料均为重量份。
  2. 根据权利要求1所述的制备方法，其特征在于：将20份壳聚糖粉末溶于35份质量分数为1％的甲酸溶液。
  3. 根据权利要求1所述的制备方法，其特征在于：加入15份聚乙二醇。
  4. 根据权利要求1所述的制备方法，其特征在于：室温下搅拌2h。
  5. 根据权利要求1所述的制备方法，其特征在于：将混合溶液在45℃下干燥18h。
  6. 根据权利要求1所述的制备方法，其特征在于：用去离子水洗涤4次。
PCT/CN2017/101828 2017-09-14 2017-09-15 一种聚乙二醇改性壳聚糖膜的制备方法 WO2019051750A1 (zh)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101020131A (zh) * 2006-02-15 2007-08-22 中国科学院大连化学物理研究所 一种用于渗透汽化分离的壳聚糖中空纤维膜的制备方法
CN103183840A (zh) * 2013-03-27 2013-07-03 四川大学 可生物降解壳聚糖化学键合交联复合膜及其制备方法
CN104144692A (zh) * 2011-12-22 2014-11-12 阿金塔生物技术公司 致密壳聚糖膜材料的组合物、制备及用途
CN105924659A (zh) * 2015-12-14 2016-09-07 威海百合生物技术股份有限公司 一种用于保健食品中壳聚糖膜的制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101020131A (zh) * 2006-02-15 2007-08-22 中国科学院大连化学物理研究所 一种用于渗透汽化分离的壳聚糖中空纤维膜的制备方法
CN104144692A (zh) * 2011-12-22 2014-11-12 阿金塔生物技术公司 致密壳聚糖膜材料的组合物、制备及用途
CN103183840A (zh) * 2013-03-27 2013-07-03 四川大学 可生物降解壳聚糖化学键合交联复合膜及其制备方法
CN105924659A (zh) * 2015-12-14 2016-09-07 威海百合生物技术股份有限公司 一种用于保健食品中壳聚糖膜的制备方法

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