WO2019049117A1 - Multi-spectral optical apparatus for biosensing applications - Google Patents

Multi-spectral optical apparatus for biosensing applications Download PDF

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Publication number
WO2019049117A1
WO2019049117A1 PCT/IB2018/058758 IB2018058758W WO2019049117A1 WO 2019049117 A1 WO2019049117 A1 WO 2019049117A1 IB 2018058758 W IB2018058758 W IB 2018058758W WO 2019049117 A1 WO2019049117 A1 WO 2019049117A1
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Prior art keywords
photodetector
led
infrared
probes
optical
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PCT/IB2018/058758
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French (fr)
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WO2019049117A8 (en
Inventor
Muralidharan GOPALAKRISHNAN
Original Assignee
Gopalakrishnan Muralidharan
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Publication of WO2019049117A1 publication Critical patent/WO2019049117A1/en
Publication of WO2019049117A8 publication Critical patent/WO2019049117A8/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/42—Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0208—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using focussing or collimating elements, e.g. lenses or mirrors; performing aberration correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0286—Constructional arrangements for compensating for fluctuations caused by temperature, humidity or pressure, or using cooling or temperature stabilization of parts of the device; Controlling the atmosphere inside a spectrometer, e.g. vacuum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0291—Housings; Spectrometer accessories; Spatial arrangement of elements, e.g. folded path arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G01J2003/102—Plural sources
    • G01J2003/104—Monochromatic plural sources
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • G01N2021/3155—Measuring in two spectral ranges, e.g. UV and visible
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • G01N2021/3181—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths using LEDs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G01N2201/0627—Use of several LED's for spectral resolution
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/121—Correction signals
    • G01N2201/1211—Correction signals for temperature

Definitions

  • the invention relates to multi-spectral optical instruments for photo-sensing utility, particularly for the sensing of the bio-parameters, chemical properties and soil health.
  • a direct transmission sensing optical spectrometer is provided in the first aspect of the invention.
  • the optical signal probes of Near-Infrared (Near-IR) LED, Infrared (IR) LED, Red LED and Green LED are placed in a LED holder.
  • the signal probes are arranged in the blood flow direction.
  • the photodetector holder contains photodetector set of visible/IR photodetectors and Near-IR photodetectors, in which photodetectors are placed next to each other and in alignment with the signal probes.
  • An optical lens between the signal probes and photodetector set focuses and amplifies the low powered optical response on the photodetector probes.
  • a non-contact MEMs/NEMs temperature bio-sensor is positioned away from the heat dissipating surface of the apparatus, for recording noise-free bio-temperature and thermal feedback.
  • the spectrometer comprises of a hollow cylindrical for finger placement, body part placement or sample placement. The proximity surface of the signal, detector and sensor probes, and hollow cylindrical area is covered with foam base. The hollow cylindrical area and foam base are utilized as the mechanical method to reduce contact vibrations errors in the real-time recording and to hold the apparatus steadily on the sensing spot. This optical technology is used to improve accuracy, alleviate radiation risks and reduce power consumption.
  • An inverted transmission sensing optical spectrometer is presented in the second aspect of the invention.
  • the optical signal probes of Near-IR LED, IR LED, Red LED and Green LED are placed in a LED holder, which is assembled in the inverted bottom surface.
  • the signal probes are arranged in the blood flow direction.
  • the photodetector holder contains photodetector set of visible/IRphotodetectors and Near- IR photodetectors, in which photodetectors are placed next to each other and in alignment with the signal probes.
  • the photodetector holder is placed in the inverted top surface.
  • An optical lens between the signal probes and photodetector set focuses and amplifies the low powered optical response on the photodetector probes.
  • a non-contact MEMs/NEMs temperature bio-sensor installed away from the heat dissipation surface, is used for recording noise-free bio-temperature and thermal feedback.
  • the spectrometer comprises of a hollow cylindrical area for finger placement, body part placement or sample placement. The proximity surface of the signal, detector and sensor probes, and hollow cylindrical area is covered with foam base. The hollow cylindrical area and foam base are utilized as the mechanical method to reduce contact vibrations errors in the recording, and as well as to hold the apparatus steadily on the sensing spot. The inverted configuration minimizes the background noise in the optical response.
  • a direct transmission sensing optical spectrometer with multijunction photodetector configuration is provided in the third of the invention.
  • the optical signal probes of Near- IR LED, IR LED, Red LED and Green LED are placed in a LED holder.
  • the signal probes are arranged in the blood flow direction.
  • the photodetector holder contains photodetector set of visible/IR photodetectors and Near-IR photodetectors, in which photodetectors are arranged in multi-junction configuration and in alignment with the signal probes.
  • An optical lens between the signal probes and photodetector set focuses and amplifies the low powered optical response on the photodetector probes.
  • a non-contact MEMs NEMs temperature bio-sensor is positioned away from the heat dissipation surface for recording noise-free bio-temperature and thermal feedback.
  • the spectrometer comprises of a hollow cylindrical for finger placement, body part placement or sample placement.
  • the proximity surface of the signal, detector and sensor probes, and hollow cylindrical area is covered with foam base.
  • the hollow cylindrical area and foam base are utilized as the mechanical method to reduce contact vibrations errors in the recording and as well hold the apparatus steadily on the sensing spot. This optical technology is utilized to improve accuracy, alleviate radiation risks and reduce power consumption of the overall hardware system.
  • An inverted transmission sensing optical spectrometer with multijunction photodetector configuration is presented in the fourth aspect of the invention.
  • the optical signal probes of Near-IR LED, IR LED, Red LED and Green LED are placed in a LED holder, which is assembled in the inverted bottom surface.
  • the signal probes are arranged in the blood flow direction.
  • the photodetector holder contains photodetector set of visible/IR photodetectors and Near-IR photodetectors, in which the photodetectors are placed in multijunction configuration and in alignment with the signal probes.
  • the photodetector holder is placed in the inverted top surface.
  • An optical lens between the signal probes and photodetector set focuses and amplifies the low powered optical response on the photodetector probes.
  • a non-contact MEMs/NEMs temperature bio -sensor is positioned away from the heat dissipation surface of the apparatus for recording noise-free bio-temperature and thermal feedback.
  • the spectrometer comprises of a hollow cylindrical for finger placement, body part placement or sample placement. The proximity surface of the signal, detector and sensor probes, and hollow cylindrical area is covered with foam base. The hollow cylindrical area and foam base are utilized as the mechanical method to reduce contact vibrations errors in the recording and as well hold the apparatus steadily on the sensing spot.
  • a disposable foam base can be used for reducing the risk of clinical infection and increasing the lifecycle of single-use device. The inverted configuration minimizes the background optical noise.
  • the spectrometer consists of optical LED signal probes set of Near-Infrared LED, Infrared LED, Red LED and Green LED.
  • the signal probes are aligned in the blood flow direction and placed near the contact plane.
  • the set of LED signal probes are arranged inside a focusing circular configuration and at a noise-free reflection distance.
  • the signal probes inject optical signals, and the reflected responses are captured by an optical lens system located at the middle plane.
  • the optical lens focuses and amplifies the low powered response on a photodetector set located at the subsequent plane.
  • the photodetector set of IR/visible and Near-Infrared probes are placed next to each other to record reflected signal response.
  • a non-contact MEMs/NEMs temperature bio-sensor is installed at a minimum distance from heat dissipation surface and at the edge of the board, for recording the error-free body temperature and the thermal noise feedback.
  • a foam base is placed in an unobstructive manner around the sensors and apparatus, which is utilized to reduce the motion errors.
  • central photodetector based reflective optical apparatus with muli-junction photodetector is provided.
  • the spectrometer consists of optical LED signal probes set of Near-Infrared LED, Infrared LED, Red LED and Green LED.
  • the signal probes are aligned in the blood flow direction and placed near the contact plane.
  • the set of LED signal probes are arranged inside a focusing circular configuration and at a noise-free reflection distance.
  • the signal probes inject optical signals, and the reflected responses are captured by an optical lens system located at the middle plane.
  • the optical lens focuses and amplifies the low powered response on a photodetector set located at the subsequent plane.
  • the photodetector set of IR/visible and Near Infrared probes are arranged in multijunction to record reflected signal response.
  • a non-contact MEMs/NEMs temperature bio-sensor is installed at the edge of at a minimum distance from heat dissipation surface for recording the error-free body temperature and the thermal noise feedback.
  • a foam base is placed in an unobstructive manner around the sensors and apparatus, which is utilized as a mechanical means to reduce the motion errors.
  • a reflective optical spectrometer technology for wide angle reflective sensing is depicted in the seventh aspect of the invention.
  • the wide angle sensing optical spectrometer comprises of input signal probes of Near-IR LED, IR LED, Red LED and Green LED, which are arranged next to each other within the light injection length.
  • the signal probes therein are aligned in the blood flow direction for real-time biological sensing applications.
  • the set of multiple optical lens are placed at a noise-free responsive distance from the signal probes, which concentrates and focuses the reflected response on the photodetectors.
  • the photodetectors set of visible/IR and Near-IR photodetectors, placed next to each other, are assembled under their corresponding optical lens to record the response signals.
  • a non- contact MEMs/NEMs temperature biosensor is placed at a minimum distance from heat dissipation surface of the apparatus. This arrangement of the non-contact temperature biosensor enables to record the body temperature and the thermal noise feedback, without any radiation noise.
  • a foam base is placed in an unobstructive manner around the sensors and apparatus, for reducing the motion errors.
  • a reflective optical spectrometer technology for wide angle reflective sensing with multijunction photodetector configuration is depicted in the eighth aspect of the invention.
  • the wide angle sensing optical spectrometer comprises of input signal probes of Near-IR LED, IR LED, Red LED and Green LED, which are arranged next to each other within the light injection length.
  • the signal probes therein are aligned in the blood flow direction for real-time biological sensing applications.
  • the set of multiple optical lens are placed at a noise-free responsive distance from the signal probes, which concentrates and focuses the reflected response on the photodetectors.
  • the photodetectors set of visible/IR and Near-IR photodetectors are placed in a multi-junction configuration under their corresponding optical lens, for recording the response signals.
  • a non-contact MEMs/NEMs temperature biosensor is placed at a minimum distance from heat dissipation surface of the apparatus. This arrangement of the non-contact temperature biosensor enables to record the body temperature and the thermal noise feedback, without any radiation error-free.
  • a foam base is placed in an unobstructive manner around the sensors and apparatus, which is used to reduce the motion errors and increase the multi-use efficiency.
  • the ninth aspect of the invention puts forth a photodetector array technology based reflective optical apparatus.
  • the optical signal probes of Near-Infrared LED, Infrared LED, Red LED and Green LED of the optical spectrometer are aligned in blood flow direction.
  • the set of signal probes are arranged next to each other within the light injection length and at a minimum response distance from the photodetector set, so that the recorded reflected response does not have a noise component.
  • the photodetection set of the spectrometer comprises of infrared/visible Red and Near Infrared photodiodes assembled in photodetector array configuration. This photodetector array arrangement assures that most of the response information is recorded.
  • a non-contact MEMs/NEMs temperature biosensor is located at a minimum distance from heat dissipation surface, which is used to record the radiation error-free body temperature and the thermal noise feedback.
  • a foam base is placed on the contact surface surrounding the sensors, signal probe and receiver area for reducing the motion errors and increasing the reusability.
  • An optical spectrometer with titled probe configuration is presented in the tenth aspect of the invention.
  • the blood flow direction aligned signal probes of Near-Infrared LED, Infrared LED, Red LED and Green LED, are titled at a small injection angle to induce a phase information in the optical signal.
  • the optical photodetector is placed inside an optical lens and a closed black box, so the reflected optical response is recorded without any optical noise.
  • a set of electrical biosensors, aligned in the blood flow direction are used for measuring the electrical bio-signal response.
  • a non-contact MEMs/NEMs temperature biosensor is placed at a radiation error-free distance for recording the body temperature and the thermal noise feedback.
  • a foam base is placed in an unobstructive manner around the sensors and apparatus, which is utilized to reduce the motion errors.
  • FIG. 1 shows an optical apparatus design for direct transmission sensing
  • FIG. 2 shows the isometric view of the direct transmission sensing optical apparatus with inverted configuration
  • FIG. 3 is the direct transmission sensing optical instrument, with multijunction
  • FIG. 4 is a multi-junction photodetector based transmission sensing optical device with inverted configuration
  • FIG. 5 is the isometric view of the central photodetector based reflective optical
  • FIG. 6 is the central photodetector based reflective optical sensing apparatus with multijunction photodetector configuration;
  • FIG. 7 shows a wide-angle sensing reflective optical spectrometer apparatus;
  • FIG. 8 is the isometric view of wide-angle sensing based reflective optical
  • FIG. 9 shows photodetector array based reflective optical sensing apparatus
  • FIG. 10A shows top isometric view of the titled reflective optical sensing
  • FIG. 10B shows the bottom view of the titled reflective optical sensing spectrometer.
  • the disclosure can be utilized and perceived in various applications that include medical sensing instruments, health management gadgets, soil health sensing devices, chemical sensing technology and material testing apparatuses.
  • the principle of the described invention is not intended to limit to the specific device or instrumentation application.
  • the disclosure can be chiefly classified into different optical apparatus designs for photo-sensing applications.
  • FIG. 1 is an optical apparatus design for direct transmission sensing.
  • the optical signal probes of Near-IR LED 1, IR LED 2, Red LED 3 and Green LED 4 are assembled in a LED holder 5.
  • the LED signal probes 1-2-3-4 with LED holder 5 is placed on the upper surface 13 for injecting signals.
  • the signals probes of 1, 2, 3 and 4 are arranged in the blood direction for real-time sensing purpose.
  • the optical lens 6 concentrates and focuses the response signal on the photodetector set of Near Infrared (Near-IR) photodetector 7 and Visible/Infrared photodetector 8.
  • the photodetector set of 7-8 are placed adjacent and in alignment to each other in a photodetector holder 9.
  • FIG. 2 is the comprehensive design of transmission sensing optical apparatus with inverted configuration.
  • the optical signal probes of Near-IR LED 1, IR LED 2, Red LED 3 and Green LED 4 are assembled in a LED holder 5.
  • the LED signal probes 1-2-3-4 with LED holder 5 is placed on the bottom surface 14 for injecting signals.
  • the signals probes of 1, 2, 3 and 4 are arranged in the blood direction for real-time sensing purpose.
  • the optical lens 6 concentrates and focuses the response signal on the photodetector set of Near Infrared photodetector 7 and Visible/Infrared (IR) photodetector 8.
  • the photodetector set of 7-8 are placed adjacent to each other in a photodetector holder 9.
  • the photodetector holder 9 with photodetector set 7-8 is assembled on the upper surface 13 for recording the output response .
  • a non-contact MEMs/NEMs temperature bio-sensor 10 is positioned away from the heat dissipation surface and at the rim of the apparatus for recording noise-free bio -temperature and thermal feedback.
  • a foam-based cushioning 11 surrounds the component area and rest of the apparatus, which helps in keeping better grip and reducing the contact vibrations.
  • the hollow cylindrical area 12 of the apparatus is used for holding the apparatus securely on the sensing spot and the sample placement. Inverted configuration of the photodetector set 7-8 and LED signal probes 1-2-3-4 minimizes background noise in the optical response.
  • FIG. 3 shows the comprehensive design of direct transmission sensing optical instrument, with multijunction photodetector configuration.
  • the optical signal probes of Near-IR LED 1, IR LED 2, Red LED 3 and Green LED 4 are assembled in a LED holder 5.
  • the LED signal probes 1-2-3-4 with LED holder 5 is placed on the upper surface 13 for injecting signals.
  • the signals probes of 1, 2, 3 and 4 are arranged in the blood direction for real-time sensing purpose.
  • the optical lens 6 concentrates and focuses the response signal on the multijunction photodetector set 15 with Near Infrared photodetector 7 and Visible/Infrared photodetector 8.
  • the photodetector set of 7 and 8 are assembled in multijunction configuration 15 with visible/Infrared Photodetector 8 on the top of the Near Infrared photodetector 7.
  • the photodetector holder 9 with photodetector set 15 is placed on the bottom surface 14 for recording the output response.
  • a non-contact MEMs/NEMs temperature bio-sensor 10 is positioned away from the heat dissipation surface for recording noise-free bio-temperature and thermal feedback.
  • a foam-based cushioning 11 surrounds the component area and rest of the apparatus, which helps in keeping better grip and reducing the contact vibrations.
  • the hollow cylindrical area 12 of the instrument is used for holding the device securely on the sensing spot and for sensing sample placement. [0029] FIG.
  • the optical signal probes of Near-IR LED 1, IR LED 2, Red LED 3 and Green LED 4 are assembled in a LED holder 5.
  • the LED signal probes 1-2-3-4 with LED holder 5 is placed on the bottom surface 14 for injecting signals.
  • the signals probes of 1, 2, 3 and 4 are arranged in the blood direction for real-time sensing purpose.
  • the optical lens 6 concentrates and focuses the response signal on the multijunction photodetector set 15 with Near Infrared photodetector 7 and Visible/Infrared photodetector 8.
  • the photodetector set of 7 and 8 are assembled in a tandem configuration 15 with Near-Infrared Photodetector 7 on the top of the visible/infrared photodetector 8.
  • the photodetector holder 9 with photodetector set 15 is placed on the upper surface 13 for recording the output response.
  • a non-contact MEMs NEMs temperature bio-sensor 10 is positioned away from the heat dissipation surface for recording noise-free bio-temperature and thermal feedback.
  • a foam-based cushioning 11 surrounds the component area and rest of the apparatus, which helps in keeping better grip and reducing the contact vibrations.
  • the device has a hollow cylindrical area 12 for holding the device securely on the sensing spot and for sample placement.
  • the inverted configuration of the photodetector set 15 and LED signal probes 1-2-3-4 is chosen to minimize the background optical noise in the response recording.
  • FIG. 5 shows the isometric view of the central photodetector based reflective optical sensing apparatus.
  • the set of signal probes of Near-Infrared LED 1, Infrared LED 2, Red LED 3 and Green LED 4 are arranged inside a focusing circular configuration 17 and at a noise-free reflection distance.
  • the LED signal probes 1-2-3-4 are aligned in the blood flow direction and placed near the contact plane 16 for real-time biological sensing purposes.
  • the reflected responses are captured by an optical lens system 18 located at the middle plane 19.
  • the optical lens system 18 concentrates and focuses the reflected response on the photodetector set of Visible/IR Photodetector 8 - Near IR Photodetector 7 located at the displaced lower plane 20.
  • FIG. 6 is the isometric view of the central photodetector based reflective optical sensing apparatus, with multi-junction photodetector arrangement.
  • the set of signal probes of Near- Infrared LED 1, Infrared LED 2, Red LED 3 and Green LED 4 are arranged inside a focusing circular configuration 17 and at a noise-free reflection distance.
  • the LED signal probes 1-2-3-4 are aligned in the blood flow direction and placed near the contact plane 16 for real-time biological sensing purpose.
  • the reflected responses are captured by an optical lens system 18 located in the middle plane 19.
  • the Visible/IR Photodetector 8 - Near IR Photodetector 7 are assembled in multijunction configuration 15 with visible/Infrared Photodetector 8 on the top of the Near Infrared photodetector 7.
  • the optical lens system 18 concentrates and focuses the reflected response on the multi-junction photodetector set 15 located at the displaced lower plane 20.
  • a non-contact MEMs NEMs temperature biosensor 10 is installed at a minimum distance from heat dissipation surface for recording the error-free body temperature and the thermal noise feedback.
  • a foam base 11 is placed in an unobstructive manner around the sensors and apparatus to reduce the motion errors. This configuration of the apparatus further reduces the power consumption and component use.
  • FIG. 7 shows the isometric view of wide-angle sensing based reflective optical spectrometer apparatus.
  • the LED signal probes of Near-IR LED 1, IR LED 2, Red LED 3 and Green LED 4 are placed within the light injection distance d.
  • the signal probes of 1, 2, 3 and 4 are aligned in the blood flow direction.
  • the set of multiple optical lens 21-22-23-24 are placed at a noise-free responsive distance around the LED signal probes of 1-2-3-4.
  • the set of Near-Infrared photodetectors 25-27-29-31 and visible photodetectors 26-28-30-32 are placed adjacent to each-other.
  • the set of Near IR- visible/Infrared photodetectors 25-26, 27-28, 29-30 and 31-32 are arranged under their corresponding optical lens system set of 21-22-23-24 for recording the reflected response.
  • a non-contact MEMs/NEMs temperature biosensor 10 is assembled at a minimum distance from heat dissipation surface of the apparatus, which is utilized for recording the temperature response and thermal noise feedback.
  • the foam base 11 is placed in an unobstructive manner around the sensors and apparatus, which is utilized for reducing the motion errors and contact vibrations in the real-time biological sensing.
  • FIG. 8 is the isometric view of wide-angle sensing optical spectrometer apparatus with multijunction photodetector configuration.
  • the LED signal probes of Near-IR LED 1, IR LED 2, Red LED 3 and Green LED 4 are placed within the light injection distance of d.
  • the signal probes of 1, 2, 3 and 4 are aligned in the blood flow direction.
  • the set of multiple optical lens 21-22-23-24 are placed at a noise-free responsive distance around the LED signal probes of 1-2-3-4.
  • the set of Near-Infrared photodetectors 25-27-29-31 and visible photodetectors 26-28-30-32 are assembled in multi-junction configuration of 33-34-35-36.
  • the set of Near IR-visible/Infrared photodetectors 25-26, 27-28, 29-30 and 31-32 in multi-junction configuration of 33-34-35-
  • a non- contact MEMs/NEMs temperature biosensor 10 is assembled at a minimum distance from heat dissipation surface, which is utilized to record the temperature response and thermal noise feedback.
  • a foam base 11 is placed in an unobstructive manner around the sensors and apparatus, for reducing the motion errors and increasing the multi-use efficiency.
  • FIG. 9 depicts the Photodiode Array based reflective optical sensing apparatus.
  • the optical signal probes of Near-Infrared LED 1, Infrared LED 2, Red LED 3 and Green LED 4 of the optical spectrometer are aligned in blood flow direction within the light injection length.
  • Photodiode array 37 comprising of visible, Infrared and Near-Infrared photodetectors are arranged in an array form around the LED set of 1, 2, 3 and 4.
  • the LED set of 1-2-3-4 and photodetector array 37 are placed at an optimal distance to elude the internal reflection noise and to detect the response signal.
  • a non- contact MEMs/NEMs temperature biosensor 10 is located at a minimum distance from heat dissipation surface, which is used for recording the radiation error-free body temperature and the thermal noise feedback.
  • FIG. 10A and FIG. 10B is the design of the titled reflective optical sensing spectrometer.
  • the signal probes of Near-Infrared LED 1, Infrared LED 2, Red LED 3 and Green LED 4 are assembled in a titled position 38 along with an optical lens system 39, which injects the optical signal.
  • the titled assembly 38 is utilized to induce a phase angle in the optical response.
  • the reflected bio-signal is focused and recorded by the optical lens 41- photodetector set 40 encased in the black box 42.
  • the set of electrodes of 43-44-45-46 are placed in a straight line with the electrical sensor 44 and electrical sensor 45 placed between the input electrical sensor 43 and draining electrode 46, which is utilized for extracting the electrical bio-response.
  • a non-contact MEMs/NEMs temperature biosensor 10 for recording the body temperature and the thermal noise feedback, is placed at a radiation error-free distance from heat dissipation surface.
  • the described technology invention can be utilized for non-invasive bio-sensing, low- powered photo-sensing, phase recognition, dispersion sensing, chemical sensing, medical sensing, compound analysis, daily health tracking application, soil health sensing, material sensing, and other forms of in-vitro and in-vivo photo sensing applications.

Abstract

Non-invasive multi-spectral optical instruments for biosensing, health tracking and photo-sensing applications. The optical apparatus comprises of wide-angle sensing design, optical phase sensing design, photodetector array design, central photodetector based low powered design and transmission optical spectrometer design. The multi-spectral optical devices can be utilized for assessing soil-health, material properties, chemical composition, phase information, dispersion pattern, biological health and real-time physiological parameters of pulse rate, hydration levels, skin health, oxygen saturation, mental stress, blood pressure levels, blood glucose levels, respiratory signals, haemoglobin levels and more.

Description

Description
Title of the Invention: Multi-spectral optical apparatus for biosensing applications
Technical Field
[0001] The invention relates to multi-spectral optical instruments for photo-sensing utility, particularly for the sensing of the bio-parameters, chemical properties and soil health.
Background of the Invention
[0002] Optical sensing has been utilized in various applications, but the optical instruments require unique configurations and designs to precisely extract different spectrometry information.
Summary of the Invention
[0003] The object of the invention is to present multi-spectral optical instruments that can be utilized for biological sensing, chemical sensing, soil= and other photo-sensing applications.
FIRST ASPECT
[0004] A direct transmission sensing optical spectrometer is provided in the first aspect of the invention. The optical signal probes of Near-Infrared (Near-IR) LED, Infrared (IR) LED, Red LED and Green LED are placed in a LED holder. For real-time sensing application, the signal probes are arranged in the blood flow direction. The photodetector holder contains photodetector set of visible/IR photodetectors and Near-IR photodetectors, in which photodetectors are placed next to each other and in alignment with the signal probes. An optical lens between the signal probes and photodetector set focuses and amplifies the low powered optical response on the photodetector probes. A non-contact MEMs/NEMs temperature bio-sensor is positioned away from the heat dissipating surface of the apparatus, for recording noise-free bio-temperature and thermal feedback. The spectrometer comprises of a hollow cylindrical for finger placement, body part placement or sample placement. The proximity surface of the signal, detector and sensor probes, and hollow cylindrical area is covered with foam base. The hollow cylindrical area and foam base are utilized as the mechanical method to reduce contact vibrations errors in the real-time recording and to hold the apparatus steadily on the sensing spot. This optical technology is used to improve accuracy, alleviate radiation risks and reduce power consumption.
SECOND ASPECT
[0005] An inverted transmission sensing optical spectrometer is presented in the second aspect of the invention. The optical signal probes of Near-IR LED, IR LED, Red LED and Green LED are placed in a LED holder, which is assembled in the inverted bottom surface. For real-time sensing applications, the signal probes are arranged in the blood flow direction. The photodetector holder contains photodetector set of visible/IRphotodetectors and Near- IR photodetectors, in which photodetectors are placed next to each other and in alignment with the signal probes. The photodetector holder is placed in the inverted top surface. An optical lens between the signal probes and photodetector set focuses and amplifies the low powered optical response on the photodetector probes. A non-contact MEMs/NEMs temperature bio-sensor, installed away from the heat dissipation surface, is used for recording noise-free bio-temperature and thermal feedback. The spectrometer comprises of a hollow cylindrical area for finger placement, body part placement or sample placement. The proximity surface of the signal, detector and sensor probes, and hollow cylindrical area is covered with foam base. The hollow cylindrical area and foam base are utilized as the mechanical method to reduce contact vibrations errors in the recording, and as well as to hold the apparatus steadily on the sensing spot. The inverted configuration minimizes the background noise in the optical response.
THIRD ASPECT
[0006] A direct transmission sensing optical spectrometer with multijunction photodetector configuration is provided in the third of the invention. The optical signal probes of Near- IR LED, IR LED, Red LED and Green LED are placed in a LED holder. For real-time sensing application, the signal probes are arranged in the blood flow direction. The photodetector holder contains photodetector set of visible/IR photodetectors and Near-IR photodetectors, in which photodetectors are arranged in multi-junction configuration and in alignment with the signal probes. An optical lens between the signal probes and photodetector set focuses and amplifies the low powered optical response on the photodetector probes. A non-contact MEMs NEMs temperature bio-sensor is positioned away from the heat dissipation surface for recording noise-free bio-temperature and thermal feedback. The spectrometer comprises of a hollow cylindrical for finger placement, body part placement or sample placement. The proximity surface of the signal, detector and sensor probes, and hollow cylindrical area is covered with foam base. The hollow cylindrical area and foam base are utilized as the mechanical method to reduce contact vibrations errors in the recording and as well hold the apparatus steadily on the sensing spot. This optical technology is utilized to improve accuracy, alleviate radiation risks and reduce power consumption of the overall hardware system.
FOURTH ASPECT
[0007] An inverted transmission sensing optical spectrometer with multijunction photodetector configuration is presented in the fourth aspect of the invention. The optical signal probes of Near-IR LED, IR LED, Red LED and Green LED are placed in a LED holder, which is assembled in the inverted bottom surface. For real-time sensing applications, the signal probes are arranged in the blood flow direction. The photodetector holder contains photodetector set of visible/IR photodetectors and Near-IR photodetectors, in which the photodetectors are placed in multijunction configuration and in alignment with the signal probes. The photodetector holder is placed in the inverted top surface. An optical lens between the signal probes and photodetector set focuses and amplifies the low powered optical response on the photodetector probes. A non-contact MEMs/NEMs temperature bio -sensor is positioned away from the heat dissipation surface of the apparatus for recording noise-free bio-temperature and thermal feedback. The spectrometer comprises of a hollow cylindrical for finger placement, body part placement or sample placement. The proximity surface of the signal, detector and sensor probes, and hollow cylindrical area is covered with foam base. The hollow cylindrical area and foam base are utilized as the mechanical method to reduce contact vibrations errors in the recording and as well hold the apparatus steadily on the sensing spot. A disposable foam base can be used for reducing the risk of clinical infection and increasing the lifecycle of single-use device. The inverted configuration minimizes the background optical noise.
FIFTH ASPECT
[0008] In the fifth aspect of the invention, lesser optical component based central photodetector based reflective optical apparatus is presented. The spectrometer consists of optical LED signal probes set of Near-Infrared LED, Infrared LED, Red LED and Green LED. For realtime sensing application, the signal probes are aligned in the blood flow direction and placed near the contact plane. The set of LED signal probes are arranged inside a focusing circular configuration and at a noise-free reflection distance. The signal probes inject optical signals, and the reflected responses are captured by an optical lens system located at the middle plane. The optical lens focuses and amplifies the low powered response on a photodetector set located at the subsequent plane. The photodetector set of IR/visible and Near-Infrared probes are placed next to each other to record reflected signal response. A non-contact MEMs/NEMs temperature bio-sensor is installed at a minimum distance from heat dissipation surface and at the edge of the board, for recording the error-free body temperature and the thermal noise feedback. A foam base is placed in an unobstructive manner around the sensors and apparatus, which is utilized to reduce the motion errors.
SIXTH ASPECT
[0009] In the sixth aspect of the invention, central photodetector based reflective optical apparatus with muli-junction photodetector is provided. The spectrometer consists of optical LED signal probes set of Near-Infrared LED, Infrared LED, Red LED and Green LED. For real-time sensing application, the signal probes are aligned in the blood flow direction and placed near the contact plane. The set of LED signal probes are arranged inside a focusing circular configuration and at a noise-free reflection distance. The signal probes inject optical signals, and the reflected responses are captured by an optical lens system located at the middle plane. The optical lens focuses and amplifies the low powered response on a photodetector set located at the subsequent plane. The photodetector set of IR/visible and Near Infrared probes are arranged in multijunction to record reflected signal response. A non-contact MEMs/NEMs temperature bio-sensor is installed at the edge of at a minimum distance from heat dissipation surface for recording the error-free body temperature and the thermal noise feedback. A foam base is placed in an unobstructive manner around the sensors and apparatus, which is utilized as a mechanical means to reduce the motion errors.
SEVENTH ASPECT
[0010] A reflective optical spectrometer technology for wide angle reflective sensing is depicted in the seventh aspect of the invention. The wide angle sensing optical spectrometer comprises of input signal probes of Near-IR LED, IR LED, Red LED and Green LED, which are arranged next to each other within the light injection length. The signal probes therein are aligned in the blood flow direction for real-time biological sensing applications. The set of multiple optical lens are placed at a noise-free responsive distance from the signal probes, which concentrates and focuses the reflected response on the photodetectors. The photodetectors set of visible/IR and Near-IR photodetectors, placed next to each other, are assembled under their corresponding optical lens to record the response signals. A non- contact MEMs/NEMs temperature biosensor is placed at a minimum distance from heat dissipation surface of the apparatus. This arrangement of the non-contact temperature biosensor enables to record the body temperature and the thermal noise feedback, without any radiation noise. A foam base is placed in an unobstructive manner around the sensors and apparatus, for reducing the motion errors.
EIGHTH ASPECT
[001 1] A reflective optical spectrometer technology for wide angle reflective sensing with multijunction photodetector configuration is depicted in the eighth aspect of the invention. The wide angle sensing optical spectrometer comprises of input signal probes of Near-IR LED, IR LED, Red LED and Green LED, which are arranged next to each other within the light injection length. The signal probes therein are aligned in the blood flow direction for real-time biological sensing applications. The set of multiple optical lens are placed at a noise-free responsive distance from the signal probes, which concentrates and focuses the reflected response on the photodetectors. The photodetectors set of visible/IR and Near-IR photodetectors are placed in a multi-junction configuration under their corresponding optical lens, for recording the response signals. A non-contact MEMs/NEMs temperature biosensor is placed at a minimum distance from heat dissipation surface of the apparatus. This arrangement of the non-contact temperature biosensor enables to record the body temperature and the thermal noise feedback, without any radiation error-free. A foam base is placed in an unobstructive manner around the sensors and apparatus, which is used to reduce the motion errors and increase the multi-use efficiency.
NINTH ASPECT
[0012] The ninth aspect of the invention puts forth a photodetector array technology based reflective optical apparatus. The optical signal probes of Near-Infrared LED, Infrared LED, Red LED and Green LED of the optical spectrometer are aligned in blood flow direction. The set of signal probes are arranged next to each other within the light injection length and at a minimum response distance from the photodetector set, so that the recorded reflected response does not have a noise component. The photodetection set of the spectrometer comprises of infrared/visible Red and Near Infrared photodiodes assembled in photodetector array configuration. This photodetector array arrangement assures that most of the response information is recorded. A non-contact MEMs/NEMs temperature biosensor is located at a minimum distance from heat dissipation surface, which is used to record the radiation error-free body temperature and the thermal noise feedback. A foam base is placed on the contact surface surrounding the sensors, signal probe and receiver area for reducing the motion errors and increasing the reusability.
TENTH ASPECT
[0013] An optical spectrometer with titled probe configuration is presented in the tenth aspect of the invention. The blood flow direction aligned signal probes, of Near-Infrared LED, Infrared LED, Red LED and Green LED, are titled at a small injection angle to induce a phase information in the optical signal. The optical photodetector is placed inside an optical lens and a closed black box, so the reflected optical response is recorded without any optical noise. A set of electrical biosensors, aligned in the blood flow direction, are used for measuring the electrical bio-signal response. A non-contact MEMs/NEMs temperature biosensor is placed at a radiation error-free distance for recording the body temperature and the thermal noise feedback. A foam base is placed in an unobstructive manner around the sensors and apparatus, which is utilized to reduce the motion errors.
Brief Description of the Artwork
[0014] FIG. 1 shows an optical apparatus design for direct transmission sensing;
[0015] FIG. 2 shows the isometric view of the direct transmission sensing optical apparatus with inverted configuration;
[0016] FIG. 3 is the direct transmission sensing optical instrument, with multijunction
photodetector configuration;
[0017] FIG. 4 is a multi-junction photodetector based transmission sensing optical device with inverted configuration;
[0018] FIG. 5 is the isometric view of the central photodetector based reflective optical
sensing apparatus;
[0019] FIG. 6 is the central photodetector based reflective optical sensing apparatus with multijunction photodetector configuration; [0020] FIG. 7 shows a wide-angle sensing reflective optical spectrometer apparatus;
[0021] FIG. 8 is the isometric view of wide-angle sensing based reflective optical
spectrometer apparatus, with multi-junction photodetector configuration;
[0022] FIG. 9 shows photodetector array based reflective optical sensing apparatus; and
[0023] FIG. 10A shows top isometric view of the titled reflective optical sensing
spectrometer; and
[0024] FIG. 10B shows the bottom view of the titled reflective optical sensing spectrometer.
Detailed Description of the invention
[0025] Comprehensively, the disclosure can be utilized and perceived in various applications that include medical sensing instruments, health management gadgets, soil health sensing devices, chemical sensing technology and material testing apparatuses. The principle of the described invention is not intended to limit to the specific device or instrumentation application. The disclosure can be chiefly classified into different optical apparatus designs for photo-sensing applications.
[0026] FIG. 1 is an optical apparatus design for direct transmission sensing. The optical signal probes of Near-IR LED 1, IR LED 2, Red LED 3 and Green LED 4 are assembled in a LED holder 5. The LED signal probes 1-2-3-4 with LED holder 5 is placed on the upper surface 13 for injecting signals. The signals probes of 1, 2, 3 and 4 are arranged in the blood direction for real-time sensing purpose. The optical lens 6 concentrates and focuses the response signal on the photodetector set of Near Infrared (Near-IR) photodetector 7 and Visible/Infrared photodetector 8. The photodetector set of 7-8 are placed adjacent and in alignment to each other in a photodetector holder 9. The photodetector holder 9 with photodetector set 7-8 is assembled on the bottom surface 14 for recording the output response. A non-contact MEMs NEMs temperature bio-sensor 10 is positioned away from the heat dissipation surface, which is utilized for recording noise-free bio-temperature and thermal feedback. A foam -based cushioning 11 surrounds the component area and rest of the apparatus, which helps in keeping better grip and reducing the contact vibrations. The device has a hollow cylindrical area 12 for holding the device securely on the sensing spot and for sensing sample placement. This design of the optical technology is intended to improve the accuracy, alleviate the radiation risks and reduce the power consumption. [0027] FIG. 2 is the comprehensive design of transmission sensing optical apparatus with inverted configuration. The optical signal probes of Near-IR LED 1, IR LED 2, Red LED 3 and Green LED 4 are assembled in a LED holder 5. The LED signal probes 1-2-3-4 with LED holder 5 is placed on the bottom surface 14 for injecting signals. The signals probes of 1, 2, 3 and 4 are arranged in the blood direction for real-time sensing purpose. The optical lens 6 concentrates and focuses the response signal on the photodetector set of Near Infrared photodetector 7 and Visible/Infrared (IR) photodetector 8. The photodetector set of 7-8 are placed adjacent to each other in a photodetector holder 9. The photodetector holder 9 with photodetector set 7-8 is assembled on the upper surface 13 for recording the output response . A non-contact MEMs/NEMs temperature bio-sensor 10 is positioned away from the heat dissipation surface and at the rim of the apparatus for recording noise-free bio -temperature and thermal feedback. A foam-based cushioning 11 surrounds the component area and rest of the apparatus, which helps in keeping better grip and reducing the contact vibrations. The hollow cylindrical area 12 of the apparatus is used for holding the apparatus securely on the sensing spot and the sample placement. Inverted configuration of the photodetector set 7-8 and LED signal probes 1-2-3-4 minimizes background noise in the optical response.
[0028] FIG. 3 shows the comprehensive design of direct transmission sensing optical instrument, with multijunction photodetector configuration. The optical signal probes of Near-IR LED 1, IR LED 2, Red LED 3 and Green LED 4 are assembled in a LED holder 5. The LED signal probes 1-2-3-4 with LED holder 5 is placed on the upper surface 13 for injecting signals. The signals probes of 1, 2, 3 and 4 are arranged in the blood direction for real-time sensing purpose. The optical lens 6 concentrates and focuses the response signal on the multijunction photodetector set 15 with Near Infrared photodetector 7 and Visible/Infrared photodetector 8. The photodetector set of 7 and 8 are assembled in multijunction configuration 15 with visible/Infrared Photodetector 8 on the top of the Near Infrared photodetector 7. The photodetector holder 9 with photodetector set 15 is placed on the bottom surface 14 for recording the output response. A non-contact MEMs/NEMs temperature bio-sensor 10 is positioned away from the heat dissipation surface for recording noise-free bio-temperature and thermal feedback. A foam-based cushioning 11 surrounds the component area and rest of the apparatus, which helps in keeping better grip and reducing the contact vibrations. The hollow cylindrical area 12 of the instrument is used for holding the device securely on the sensing spot and for sensing sample placement. [0029] FIG. 4 is a multijunction photodetector based transmission sensing optical device with inverted configuration. The optical signal probes of Near-IR LED 1, IR LED 2, Red LED 3 and Green LED 4 are assembled in a LED holder 5. The LED signal probes 1-2-3-4 with LED holder 5 is placed on the bottom surface 14 for injecting signals. The signals probes of 1, 2, 3 and 4 are arranged in the blood direction for real-time sensing purpose. The optical lens 6 concentrates and focuses the response signal on the multijunction photodetector set 15 with Near Infrared photodetector 7 and Visible/Infrared photodetector 8. The photodetector set of 7 and 8 are assembled in a tandem configuration 15 with Near-Infrared Photodetector 7 on the top of the visible/infrared photodetector 8. The photodetector holder 9 with photodetector set 15 is placed on the upper surface 13 for recording the output response. A non-contact MEMs NEMs temperature bio-sensor 10 is positioned away from the heat dissipation surface for recording noise-free bio-temperature and thermal feedback. A foam-based cushioning 11 surrounds the component area and rest of the apparatus, which helps in keeping better grip and reducing the contact vibrations. The device has a hollow cylindrical area 12 for holding the device securely on the sensing spot and for sample placement. The inverted configuration of the photodetector set 15 and LED signal probes 1-2-3-4 is chosen to minimize the background optical noise in the response recording.
[0030] FIG. 5 shows the isometric view of the central photodetector based reflective optical sensing apparatus. The set of signal probes of Near-Infrared LED 1, Infrared LED 2, Red LED 3 and Green LED 4 are arranged inside a focusing circular configuration 17 and at a noise-free reflection distance. The LED signal probes 1-2-3-4 are aligned in the blood flow direction and placed near the contact plane 16 for real-time biological sensing purposes. The reflected responses are captured by an optical lens system 18 located at the middle plane 19. The optical lens system 18 concentrates and focuses the reflected response on the photodetector set of Visible/IR Photodetector 8 - Near IR Photodetector 7 located at the displaced lower plane 20. The set of photodetectors of Visible/IR Photodetector 8 - Near IR Photodetector 7 are placed next to each other for recording the reflected optical response . A non-contact MEMs/NEMs temperature bio-sensor 10 is installed at a minimum distance from heat dissipation surface for recording the error-free body temperature and the thermal noise feedback. A foam base 11 is placed in an unobstructive manner around the sensors and apparatus to reduce the motion errors. This configuration of the optical spectrometer apparatus significantly reduces the power consumption and component use. [0031] FIG. 6 is the isometric view of the central photodetector based reflective optical sensing apparatus, with multi-junction photodetector arrangement. The set of signal probes of Near- Infrared LED 1, Infrared LED 2, Red LED 3 and Green LED 4 are arranged inside a focusing circular configuration 17 and at a noise-free reflection distance. The LED signal probes 1-2-3-4 are aligned in the blood flow direction and placed near the contact plane 16 for real-time biological sensing purpose. The reflected responses are captured by an optical lens system 18 located in the middle plane 19. The Visible/IR Photodetector 8 - Near IR Photodetector 7 are assembled in multijunction configuration 15 with visible/Infrared Photodetector 8 on the top of the Near Infrared photodetector 7. The optical lens system 18 concentrates and focuses the reflected response on the multi-junction photodetector set 15 located at the displaced lower plane 20. A non-contact MEMs NEMs temperature biosensor 10 is installed at a minimum distance from heat dissipation surface for recording the error-free body temperature and the thermal noise feedback. A foam base 11 is placed in an unobstructive manner around the sensors and apparatus to reduce the motion errors. This configuration of the apparatus further reduces the power consumption and component use.
[0032] FIG. 7 shows the isometric view of wide-angle sensing based reflective optical spectrometer apparatus. The LED signal probes of Near-IR LED 1, IR LED 2, Red LED 3 and Green LED 4 are placed within the light injection distance d. For real-time sensing purposes, the signal probes of 1, 2, 3 and 4 are aligned in the blood flow direction. The set of multiple optical lens 21-22-23-24 are placed at a noise-free responsive distance around the LED signal probes of 1-2-3-4. The set of Near-Infrared photodetectors 25-27-29-31 and visible photodetectors 26-28-30-32 are placed adjacent to each-other. The set of Near IR- visible/Infrared photodetectors 25-26, 27-28, 29-30 and 31-32 are arranged under their corresponding optical lens system set of 21-22-23-24 for recording the reflected response. A non-contact MEMs/NEMs temperature biosensor 10 is assembled at a minimum distance from heat dissipation surface of the apparatus, which is utilized for recording the temperature response and thermal noise feedback. The foam base 11 is placed in an unobstructive manner around the sensors and apparatus, which is utilized for reducing the motion errors and contact vibrations in the real-time biological sensing.
[0033] FIG. 8 is the isometric view of wide-angle sensing optical spectrometer apparatus with multijunction photodetector configuration. The LED signal probes of Near-IR LED 1, IR LED 2, Red LED 3 and Green LED 4 are placed within the light injection distance of d. For real-time sensing purposes, the signal probes of 1, 2, 3 and 4 are aligned in the blood flow direction. The set of multiple optical lens 21-22-23-24 are placed at a noise-free responsive distance around the LED signal probes of 1-2-3-4. The set of Near-Infrared photodetectors 25-27-29-31 and visible photodetectors 26-28-30-32 are assembled in multi-junction configuration of 33-34-35-36. The set of Near IR-visible/Infrared photodetectors 25-26, 27-28, 29-30 and 31-32 in multi-junction configuration of 33-34-35-
36 are arranged under their corresponding optical lens system set of 21-22-23-24. A non- contact MEMs/NEMs temperature biosensor 10 is assembled at a minimum distance from heat dissipation surface, which is utilized to record the temperature response and thermal noise feedback. A foam base 11 is placed in an unobstructive manner around the sensors and apparatus, for reducing the motion errors and increasing the multi-use efficiency.
[0034] FIG. 9 depicts the Photodiode Array based reflective optical sensing apparatus. The optical signal probes of Near-Infrared LED 1, Infrared LED 2, Red LED 3 and Green LED 4 of the optical spectrometer are aligned in blood flow direction within the light injection length. Photodiode array 37 comprising of visible, Infrared and Near-Infrared photodetectors are arranged in an array form around the LED set of 1, 2, 3 and 4. The LED set of 1-2-3-4 and photodetector array 37 are placed at an optimal distance to elude the internal reflection noise and to detect the response signal. The photodetector array assembly
37 is used to record the phase information, dispersion pattern and reflection pattern. A non- contact MEMs/NEMs temperature biosensor 10 is located at a minimum distance from heat dissipation surface, which is used for recording the radiation error-free body temperature and the thermal noise feedback.
[0035] FIG. 10A and FIG. 10B is the design of the titled reflective optical sensing spectrometer.
The signal probes of Near-Infrared LED 1, Infrared LED 2, Red LED 3 and Green LED 4 are assembled in a titled position 38 along with an optical lens system 39, which injects the optical signal. The titled assembly 38 is utilized to induce a phase angle in the optical response. The reflected bio-signal is focused and recorded by the optical lens 41- photodetector set 40 encased in the black box 42. The set of electrodes of 43-44-45-46 are placed in a straight line with the electrical sensor 44 and electrical sensor 45 placed between the input electrical sensor 43 and draining electrode 46, which is utilized for extracting the electrical bio-response. A non-contact MEMs/NEMs temperature biosensor 10, for recording the body temperature and the thermal noise feedback, is placed at a radiation error-free distance from heat dissipation surface. [0036] The above described invention disclosure is intended for illustration purposes, and for those skilled in the art may instantly perceive numerous modifications, variations and equivalents. Therefore, the disclosure is not exhaustive in broader aspects and the invention is not intended to limit to specific details. All equivalents and modifications are intended to be included within the scope of disclosure and attached claims. Accordingly, additional changes and modifications may be made without departing from the scope or spirit of the invention disclosure appended in the document, claims and their equivalents
Industrial Applicability
[0037] The described technology invention can be utilized for non-invasive bio-sensing, low- powered photo-sensing, phase recognition, dispersion sensing, chemical sensing, medical sensing, compound analysis, daily health tracking application, soil health sensing, material sensing, and other forms of in-vitro and in-vivo photo sensing applications.
Prior Art and Citation List
No relevant prior art exists.

Claims

Claims Hereto the following are claimed:
1. A transmittive optical spectrometer, comprising of:
LED signals probes of Near-Infrared LED, Infrared LED, Red LED and Green LED assembled in a LED holder and arranged in the blood flow direction;
the LED holder with LED signal probes arranged in signal transmission configuration;
Photodetector set of Near-Infrared Photodetector and visible/ Infrared Photodetector assembled in a photodetector holder and in alignment with the LED signal probes;
the photodetector holder with photodetector probes arranged in the transmission response receiving configuration;
an optical lens placed before the photodetector probes that is used as the means to concentrate and focus the light on the photodetector signal probes;
a non-contact MEMs/NEMs temperature bio-sensor, which is utilized for recording noise- free temperature and thermal feedback;
the temperature sensor positioned away from the heat dissipation surface;
a hollow cylindrical area, which is utilized for placing the finger, body part or sensing sample; and
a foam base surrounding the hollow cylindrical area, signal probes, detector probes and sensor probes; and
the hollow cylindrical area and the foam base, as the means to reduce the contact vibrations in the real-time sensing applications.
2. The apparatus of Claim 1, further comprising of multi-junction photodetector
arrangement, wherein:
the photodetector probes of higher bandgap are placed on the top of the photodetectors with lesser bandgap; and
visible/Infrared photodetector is placed on the top of the of the Near Infrared
photodetector.
3. The apparatus of Claim 1 with an inverted configuration, wherein:
the LED signal probes with holder is assembled on the bottom surface;
the photodetector probes with holder is assembled on the top surface, which is used for avoiding the ambient light noise in the recorded response; and
the inverted configuration of the signal probes and photodetector, as the means to evade the background optical noise.
The apparatus of Claim 2 with an inverted configuration, wherein:
the LED signal probes with holder is assembled on the bottom surface;
the multijunction photodetector with holder is assembled on the top surface, which is utilized for avoiding the ambient light noise in the recorded response; and
the inverted configuration of the signal probes and photodetector, as the means to evade the background optical noise.
The Central photodetector based reflective optical apparatus, comprising of:
optical signal probes of Near-Infrared LED, Infrared LED, Red LED and Green LED assembled inside a focusing circular configuration;
the optical signal probes arranged at a minimum noise-free distance to elude internal reflections in the response;
optical LED signal probes aligned in the blood flow direction and arranged near the contact plane, for sensing real-time biological signals;
a photodetection system containing an optical lens system and a photodetector set;
the photodetector set containing Infrared/visible photodetector probe and Near-Infrared photodetector probe assembled at the bottom plane, which is utilized for recording the reflected response;
the adjacent arrangement of photodetector set, where Infrared/visible photodetector probe and Near Infrared photodetector probe are placed adjacent to each other;
the optical lens system assembled at the middle plane between the signal probes and photodetector probes, which is utilized as the means to focus and concentrate the reflected response on the photodetectors;
a non-contact MEMs/NEMs temperature bio-sensor assembled at a minimum distance from heat dissipation surface, which is utilized to record the radiation error-free body temperature and the thermal noise feedback; and
a foam base placed in an unobstructive manner around the sensors, which utilized as a means to reduce the contact vibration and motion errors.
6. The apparatus of Claim 5, further comprising of multi-junction photodetector arrangement, wherein:
the photodetector probes of higher bandgap are placed on the top of the photodetectors with lesser bandgap; and
visible/Infrared photodetector is placed on the top of the of the Near Infrared photodetector.
7. The design of a wide-angle sensing reflective optical apparatus, comprising of:
optical signal probes of Near-Infrared LED, Infrared LED, Red LED and Green LED aligned in the blood flow direction for real-time sensing applications;
the optical signal probes assembled next to each other within the light injection distance; a set of multiple optical lens assembled at a noise-free responsive distance from the LED signal probes;
a set of multiple photodetectors of visible/Infrared and Near-Infrared photodetectors installed at a responsive distance under their corresponding optical lens, for recording the response signals without the internal reflection noises;
the set of visible/Infrared and Near-Infrared photodetector probes placed adjacent to each other and aligned with their corresponding signal probes;
the set of multiple optical lens system as the means to focus and concentrate the reflected response on the photodetectors;
a non-contact MEMs/NEMs temperature bio-sensor assembled at a minimum distance from heat dissipation surface, which is utilized to record the radiation error-free temperature and the thermal noise feedback; and
a foam base placed in an unobstructive manner around the sensors, which utilized as a means to reduce the contact vibration and motion errors.
8. The apparatus of Claim 7, further comprising of multi-junction photodetector
arrangement, wherein:
the photodetector probes of higher bandgap are placed on the top of the photodetectors with lesser bandgap; and
the set of multiple visible/Infrared photodetectors are placed on the top of the of their corresponding Near Infrared photodetectors.
9. The design of photodetector array based reflective optical apparatus, comprising of: optical signal probes of Near-Infrared LED, Infrared LED, Red LED and Green LED aligned and assembled within the light injection length and according to the Claim 7; photodetector array assembled at a minimum measurement distance around the LED signal probes, for recording the response signal without the internal reflection noises; the photodetector array assembly as the means to record the phase information, dispersion pattern and reflection pattern;
a non-contact MEMs/NEMs temperature bio-sensor assembled at a minimum distance from heat dissipation surface, which is utilized to record the radiation error-free body temperature and the thermal noise feedback; and
a foam base placed in an unobstructive manner around the sensors, which utilized as a means to reduce the contact vibration and motion errors.
10. The phase sensing optical apparatus, comprising of:
signal probes of Near-Infrared LED, Infrared LED, Red LED and Green LED titled at a phase injection angle;
the signal probes aligned in the blood flow direction for the real-time sensing application; an optical lens system arranged at the signal probe end;
a photodetector set and an optical lens system assembled at the response recording spot; the photodetector set and the lens system enclosed in a box casing, which is used as the means evade external optical noise;
the titled assembly of the signal probes as the means to induce and record the phase information;
a set of electrical bio-sensors aligned in the blood flow direction, which is used as the means to record electrical signals and electrical bio-signals;
the response recording electrical sensors placed between the input electrical sensor and drain electrical sensor; and
a non-contact MEMs/NEMs temperature bio-sensor assembled at a minimum distance from heat dissipation surface, which is utilized to record the radiation error-free body temperature and the thermal noise feedback.
PCT/IB2018/058758 2017-09-11 2018-11-08 Multi-spectral optical apparatus for biosensing applications WO2019049117A1 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11389092B2 (en) 2019-08-20 2022-07-19 Samsung Electronics Co., Ltd. Apparatus and method for estimating bio-information

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11600365B2 (en) 2017-12-12 2023-03-07 Vyaire Medical, Inc. Nasal and oral respiration sensor
KR20200111492A (en) * 2019-03-19 2020-09-29 삼성전자주식회사 Electronic device and method for notification of biometric information in electronic device
FI3982821T3 (en) * 2019-06-11 2024-03-25 Sunmed Group Holdings Llc Nasal and oral respiration sensor
EP4075955A4 (en) * 2019-12-20 2023-12-20 Xiant Technologies, Inc. Mobile real time location unit
TWI799087B (en) * 2021-05-19 2023-04-11 英屬開曼群島商大峽谷智慧照明系統股份有限公司 Compilation method of dynamic spectrum program and human-caused lighting method thereof
WO2022265613A1 (en) * 2021-06-18 2022-12-22 Cankaya Universitesi Blood-free continuous blood glucose meter
US20230270337A1 (en) * 2022-02-28 2023-08-31 Hb Innovations, Inc. System and method for video detection of breathing rates
CN114675553B (en) * 2022-03-22 2023-03-24 慕思健康睡眠股份有限公司 Control method, device, equipment and medium for intelligent home system

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703689A (en) * 1996-06-11 1997-12-30 Varian Associates, Inc. Optical spectrometer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5823966A (en) * 1997-05-20 1998-10-20 Buchert; Janusz Michal Non-invasive continuous blood glucose monitoring
US9430938B2 (en) * 2013-03-04 2016-08-30 Hello Inc. Monitoring device with selectable wireless communication
US10361001B2 (en) * 2015-09-23 2019-07-23 Athena Gtx, Inc. Autonomous critical care systems and integrated combat casualty care systems

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703689A (en) * 1996-06-11 1997-12-30 Varian Associates, Inc. Optical spectrometer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIELECKI, Z.: "Maximisation of signal-to-noise ratio in infrared radiation receivers", OPTOELECTRONICS REVIEW, vol. 3, 31 December 2002 (2002-12-31), pages 209 - 216 *
KISOMI, ALIREZA AVAKH ET AL.: "Towards a multi-wavelength spectroscopy platform for blood characterization and analysis", 2016 38TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 18 October 2016 (2016-10-18), pages 2994 - 2997, XP032979804, DOI: 10.1109/EMBC.2016.7591359 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11389092B2 (en) 2019-08-20 2022-07-19 Samsung Electronics Co., Ltd. Apparatus and method for estimating bio-information

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