WO2019038428A3 - Mrt-kontrastmittel, verwendung zur temperaturmessung und verfahren zur temperaturmessung - Google Patents

Mrt-kontrastmittel, verwendung zur temperaturmessung und verfahren zur temperaturmessung Download PDF

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Publication number
WO2019038428A3
WO2019038428A3 PCT/EP2018/072893 EP2018072893W WO2019038428A3 WO 2019038428 A3 WO2019038428 A3 WO 2019038428A3 EP 2018072893 W EP2018072893 W EP 2018072893W WO 2019038428 A3 WO2019038428 A3 WO 2019038428A3
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WO
WIPO (PCT)
Prior art keywords
measuring temperature
magnetic resonance
contrast media
resonance tomography
measuring
Prior art date
Application number
PCT/EP2018/072893
Other languages
English (en)
French (fr)
Other versions
WO2019038428A2 (de
Inventor
Rainer Herges
Marcel DOMMASCHK
Gernot HEITMANN
Jens Gröbner
Vanessa THOMS
Original Assignee
Christian-Albrechts-Universität Zu Kiel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Christian-Albrechts-Universität Zu Kiel filed Critical Christian-Albrechts-Universität Zu Kiel
Priority to EP18765578.2A priority Critical patent/EP3672643A2/de
Publication of WO2019038428A2 publication Critical patent/WO2019038428A2/de
Publication of WO2019038428A3 publication Critical patent/WO2019038428A3/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Die Erfindung betrifft ein Verfahren zur Messung und Darstellung der Temperatur in drei Dimensionen, insbesondere in lebendem Gewebe unter Einsatz von Methoden der magnetischen Kernspinresonanz (NMR), sowie die Verwendung von neuartigen metallorganischen Komplexen als Kontrastmittel zur Messung und Darstellung der Temperatur in drei Dimensionen im bildgebenden Verfahren der Magnetresonanztomographie (MRT).
PCT/EP2018/072893 2017-08-25 2018-08-24 Neuartiges mrt-kontrastmittel, verwendung zur temperaturmessung und verfahren zur temperaturmessung WO2019038428A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP18765578.2A EP3672643A2 (de) 2017-08-25 2018-08-24 Mrt-kontrastmittel, verwendung zur temperaturmessung und verfahren zur temperaturmessung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017119482.7A DE102017119482A1 (de) 2017-08-25 2017-08-25 Neuartiges MRT-Kontrastmittel, Verwendung zur Temperaturmessung und Verfahren zur Temperaturmessung
DEDE102017119482.7 2017-08-25

Publications (2)

Publication Number Publication Date
WO2019038428A2 WO2019038428A2 (de) 2019-02-28
WO2019038428A3 true WO2019038428A3 (de) 2019-04-18

Family

ID=65320738

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2018/072893 WO2019038428A2 (de) 2017-08-25 2018-08-24 Neuartiges mrt-kontrastmittel, verwendung zur temperaturmessung und verfahren zur temperaturmessung

Country Status (3)

Country Link
EP (1) EP3672643A2 (de)
DE (1) DE102017119482A1 (de)
WO (1) WO2019038428A2 (de)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010034496A1 (de) * 2010-08-16 2012-02-16 Christian-Albrechts-Universität Zu Kiel Photosensiver molekularer Schalter mit einem Chelat-Liganden und isomerisierbarem photochromem System

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4318369C1 (de) 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010034496A1 (de) * 2010-08-16 2012-02-16 Christian-Albrechts-Universität Zu Kiel Photosensiver molekularer Schalter mit einem Chelat-Liganden und isomerisierbarem photochromem System

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GERNOT HEITMANN ET AL: "Modular Synthetic Route to Monofunctionalized Porphyrin Architectures", ORGANIC LETTERS, vol. 18, no. 20, 7 October 2016 (2016-10-07), US, pages 5228 - 5231, XP055549302, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.6b02507 *
MARCEL DOMMASCHK ET AL: "Photoswitchable Magnetic Resonance Imaging Contrast by Improved Light-Driven Coordination-Induced Spin State Switch", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 137, no. 24, 5 May 2015 (2015-05-05), pages 7552 - 7555, XP055549308, ISSN: 0002-7863, DOI: 10.1021/jacs.5b00929 *
RAINER HERGES: "Spinschaltung und intelligente Kontrastmittel in der MRT", NACHRICHTEN AUS DER CHEMIE, 1 September 2011 (2011-09-01), pages 817 - 821, XP055549420, Retrieved from the Internet <URL:https://www.degruyter.com/view/j/nachrchem.2011.59.9/nachrchem.2011.59.9.817/nachrchem.2011.59.9.817.xml> [retrieved on 20190130] *

Also Published As

Publication number Publication date
DE102017119482A1 (de) 2019-02-28
EP3672643A2 (de) 2020-07-01
WO2019038428A2 (de) 2019-02-28

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