WO2019035602A3 - 혈액 내 gkn1 단백을 이용하는 위암 진단 - Google Patents

혈액 내 gkn1 단백을 이용하는 위암 진단 Download PDF

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Publication number
WO2019035602A3
WO2019035602A3 PCT/KR2018/009149 KR2018009149W WO2019035602A3 WO 2019035602 A3 WO2019035602 A3 WO 2019035602A3 KR 2018009149 W KR2018009149 W KR 2018009149W WO 2019035602 A3 WO2019035602 A3 WO 2019035602A3
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WO
WIPO (PCT)
Prior art keywords
stomach cancer
blood
cancer diagnosis
gkn1
composition
Prior art date
Application number
PCT/KR2018/009149
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English (en)
French (fr)
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WO2019035602A9 (ko
WO2019035602A2 (ko
Inventor
박원상
윤정환
Original Assignee
가톨릭대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020170103383A external-priority patent/KR101988118B1/ko
Priority claimed from KR1020170105210A external-priority patent/KR101988120B1/ko
Application filed by 가톨릭대학교 산학협력단 filed Critical 가톨릭대학교 산학협력단
Priority to JP2020508522A priority Critical patent/JP7041246B2/ja
Publication of WO2019035602A2 publication Critical patent/WO2019035602A2/ko
Publication of WO2019035602A3 publication Critical patent/WO2019035602A3/ko
Publication of WO2019035602A9 publication Critical patent/WO2019035602A9/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 GKN1 단백(Gastrokine 1 Protein) 수준을 측정하는 제제를 포함하는 위암 진단용 조성물 또는 상기 조성물을 포함하는 위암 진단용 키트에 관한 것이며, 또한, GKN1 단백(Gastrokine 1 Protein)을 유효성분으로 포함하는 위암의 예방 또는 치료용 조성물에 관한 것이다.
PCT/KR2018/009149 2017-08-16 2018-08-10 혈액 내 gkn1 단백을 이용하는 위암 진단 WO2019035602A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020508522A JP7041246B2 (ja) 2017-08-16 2018-08-10 血液内のｇｋｎ１タンパクを利用する胃癌診断

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2017-0103383 2017-08-16
KR1020170103383A KR101988118B1 (ko) 2017-08-16 2017-08-16 Gkn1 단백을 포함하는 항암 조성물
KR10-2017-0105210 2017-08-21
KR1020170105210A KR101988120B1 (ko) 2017-08-21 2017-08-21 혈액 내 gastrokine 1 단백을 이용하는 위암 진단

Publications (3)

Publication Number Publication Date
WO2019035602A2 WO2019035602A2 (ko) 2019-02-21
WO2019035602A3 true WO2019035602A3 (ko) 2019-04-25
WO2019035602A9 WO2019035602A9 (ko) 2019-06-06

Family

ID=65361904

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/009149 WO2019035602A2 (ko) 2017-08-16 2018-08-10 혈액 내 gkn1 단백을 이용하는 위암 진단

Country Status (2)

Country Link
JP (1) JP7041246B2 (ko)
WO (1) WO2019035602A2 (ko)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120051258A (ko) * 2010-11-12 2012-05-22 가톨릭대학교 산학협력단 Ｇｋｎ １을 함유하는 항암용 조성물
WO2014099400A2 (en) * 2012-12-19 2014-06-26 The University Of Chicago Uses of a gastrokine protein

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004047968A1 (de) * 2004-10-01 2006-04-06 B.R.A.H.M.S Ag Bestimmung von Gastrokine 1 (GKN1) als Biomarker für Entzündungen und Infektionen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120051258A (ko) * 2010-11-12 2012-05-22 가톨릭대학교 산학협력단 Ｇｋｎ １을 함유하는 항암용 조성물
WO2014099400A2 (en) * 2012-12-19 2014-06-26 The University Of Chicago Uses of a gastrokine protein

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HASAN, AMER A. ET AL: "Down-regulated Gene Expression of GKN1 and GKN2 as Diagnostic Markers for Gastric Cancer", ENGINEERING AND TECHNOLOGY , INTERNATIONAL JOURNAL OF MEDICAL AND HEALTH SCIENCES, vol. 9, no. 6, 2015, pages 532 - 535, XP055594987 *
NARDONE, G. ET AL.: "Gastrokine 1 Expression in Patients with and without Helicobacter Pylori Infection", DIGESTIVE AND LIVER DISEASE, vol. 39, no. 2, 2007, pages 122 - 129, XP005735663 *
SCARANO, MARIA IRENE ET AL.: "Role of Gastrokine 1 in Gastric Cancer: A Potential Diagnostic Marker and Antitumor Drug", CUTTING EDGE THERAPIES FOR CANCER IN THE 21ST CENTURY, 2014, pages 253 - 270, XP055598310 *

Also Published As

Publication number Publication date
WO2019035602A9 (ko) 2019-06-06
WO2019035602A2 (ko) 2019-02-21
JP7041246B2 (ja) 2022-03-23
JP2020531811A (ja) 2020-11-05

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