WO2019031729A3 - Use of composition comprising stem cell-derived exosome as effective ingredient in alleviating non-alcoholic simple steatosis or non-alcoholic steatohepatitis - Google Patents

Use of composition comprising stem cell-derived exosome as effective ingredient in alleviating non-alcoholic simple steatosis or non-alcoholic steatohepatitis Download PDF

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Publication number
WO2019031729A3
WO2019031729A3 PCT/KR2018/008325 KR2018008325W WO2019031729A3 WO 2019031729 A3 WO2019031729 A3 WO 2019031729A3 KR 2018008325 W KR2018008325 W KR 2018008325W WO 2019031729 A3 WO2019031729 A3 WO 2019031729A3
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WO
WIPO (PCT)
Prior art keywords
alcoholic
simple steatosis
composition
stem cell
alcoholic steatohepatitis
Prior art date
Application number
PCT/KR2018/008325
Other languages
French (fr)
Korean (ko)
Other versions
WO2019031729A2 (en
Inventor
이용원
조병성
Original Assignee
주식회사 엑소코바이오
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Publication date
Priority claimed from KR1020170162555A external-priority patent/KR20190015063A/en
Application filed by 주식회사 엑소코바이오 filed Critical 주식회사 엑소코바이오
Publication of WO2019031729A2 publication Critical patent/WO2019031729A2/en
Publication of WO2019031729A3 publication Critical patent/WO2019031729A3/en

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention provides a composition comprising a stem cell-derived exosome as an effective ingredient for preventing, relieving, alleviating, or treating non-alcoholic simple steatosis or non-alcoholic steatohepatitis. A composition of the present invention can prevent, relieve, alleviate, or treat non-alcoholic simple steatosis or non-alcoholic steatohepatitis by reducing or relieving fat accumulation or inflammation in hepatocytes or liver tissues, which acts as a cause of non-alcoholic simple steatosis or non-alcoholic steatohepatitis and by inducing the histological state of non-alcoholic simple steatosis or non-alcoholic steatohepatitis to moderate, improve, or change for the better.
PCT/KR2018/008325 2017-08-05 2018-07-24 Use of composition comprising stem cell-derived exosome as effective ingredient in alleviating non-alcoholic simple steatosis or non-alcoholic steatohepatitis WO2019031729A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20170099328 2017-08-05
KR10-2017-0099328 2017-08-05
KR10-2017-0162555 2017-11-30
KR1020170162555A KR20190015063A (en) 2017-08-05 2017-11-30 A composition comprising an exosome and/or extracellular vesicle derived from stem cell as an active ingredient and its application for improving non-alcoholic simple steatosis or non-alcoholic steatohepatitis

Publications (2)

Publication Number Publication Date
WO2019031729A2 WO2019031729A2 (en) 2019-02-14
WO2019031729A3 true WO2019031729A3 (en) 2019-05-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/008325 WO2019031729A2 (en) 2017-08-05 2018-07-24 Use of composition comprising stem cell-derived exosome as effective ingredient in alleviating non-alcoholic simple steatosis or non-alcoholic steatohepatitis

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WO (1) WO2019031729A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022544698A (en) * 2019-08-22 2022-10-20 プレクソジェン インコーポレイテッド Composition for prevention or treatment of non-alcoholic steatohepatitis containing exosomes derived from induced pluripotent stem cell-derived mesenchymal stem cell progenitor cells
US20230115023A1 (en) * 2021-10-07 2023-04-13 China Medical University Use of exosomes derived from mesenchymal stem cells fortreating non-alcoholic steatohepatitis
CN115386543B (en) * 2022-07-19 2024-02-02 长春科技学院 Pilose antler stem cell exosome and preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101501433B1 (en) * 2014-06-10 2015-03-11 주식회사 머쉬메드 A composition for prevention and treatment of non-alcoholic fatty liver disease
WO2016054094A1 (en) * 2014-09-30 2016-04-07 Research Institute At Nationwide Children's Hospital Compositions and methods for treating hepatic fibrosis
CN106974937A (en) * 2017-03-30 2017-07-25 山东大学 Application of the adipose-derived mescenchymal stem cell excretion body in treatment metabolic syndrome medicine is prepared

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101501433B1 (en) * 2014-06-10 2015-03-11 주식회사 머쉬메드 A composition for prevention and treatment of non-alcoholic fatty liver disease
WO2016054094A1 (en) * 2014-09-30 2016-04-07 Research Institute At Nationwide Children's Hospital Compositions and methods for treating hepatic fibrosis
CN106974937A (en) * 2017-03-30 2017-07-25 山东大学 Application of the adipose-derived mescenchymal stem cell excretion body in treatment metabolic syndrome medicine is prepared

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HU , LI ET AL.: "Exosomes Derived from Human Adipose Mensenchymal Stem Cells Accelerates Cutaneous Wound Healing via Optimizing the Characteristics of Fibroblasts", SCIENTIFIC REPORTS, vol. 6, 2016, pages 1 - 1 1, XP055485849, DOI: doi:10.1038/srep32993 *
LEE, YOUNG-SUN ET AL.: "Exosomes Derived from Palmitic Acid-treated Hepatocytes Induce Fibrotic Activation of Hepatic Stellate Cells", SCIENTIFIC REPORTS, vol. 7, no. 1, 16 June 2017 (2017-06-16), pages 1 - 10, XP055608796, ISSN: 2045-2322, DOI: 10.1038/s41598-017-03389-2 *

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WO2019031729A2 (en) 2019-02-14

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