WO2019004738A3 - Use of composition comprising adipose stem cell-derived exosome as effective ingredient in alleviating dermatitis - Google Patents

Use of composition comprising adipose stem cell-derived exosome as effective ingredient in alleviating dermatitis Download PDF

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Publication number
WO2019004738A3
WO2019004738A3 PCT/KR2018/007326 KR2018007326W WO2019004738A3 WO 2019004738 A3 WO2019004738 A3 WO 2019004738A3 KR 2018007326 W KR2018007326 W KR 2018007326W WO 2019004738 A3 WO2019004738 A3 WO 2019004738A3
Authority
WO
WIPO (PCT)
Prior art keywords
dermatitis
composition
stem cell
effective ingredient
adipose stem
Prior art date
Application number
PCT/KR2018/007326
Other languages
French (fr)
Korean (ko)
Other versions
WO2019004738A2 (en
Inventor
이용원
조병성
Original Assignee
주식회사 엑소코바이오
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020180018617A external-priority patent/KR20190003316A/en
Application filed by 주식회사 엑소코바이오 filed Critical 주식회사 엑소코바이오
Priority to CN201880054562.0A priority Critical patent/CN111148520B/en
Priority to EP18824926.2A priority patent/EP3639832B1/en
Priority to JP2019571619A priority patent/JP6970459B2/en
Publication of WO2019004738A2 publication Critical patent/WO2019004738A2/en
Publication of WO2019004738A3 publication Critical patent/WO2019004738A3/en
Priority to US16/727,739 priority patent/US11612621B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Developmental Biology & Embryology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention provides a composition comprising adipose stem cell-derived exosomes as an effective ingredient for preventing, alleviating, reducing, or treating dermatitis. Acting on multiple cytokine targets causative of dermatitis, a composition according to the present invention can be applied to a wide spectrum of dermatitis attributed to various causes and can effectively suppress or reduce dermatitis. In addition, the composition of the present invention can reduce moisture evaporation of the stratum corneum and improve skin moisturization to protect and reinforce skin barriers whereby dermatitis can be prevented, alleviated, reduced, or treated.
PCT/KR2018/007326 2017-06-30 2018-06-28 Use of composition comprising adipose stem cell-derived exosome as effective ingredient in alleviating dermatitis WO2019004738A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201880054562.0A CN111148520B (en) 2017-06-30 2018-06-28 Use of composition comprising exosomes derived from adipose-derived stem cells as active ingredient for improving dermatitis
EP18824926.2A EP3639832B1 (en) 2017-06-30 2018-06-28 Use of composition comprising adipose stem cell-derived exosome as effective ingredient in alleviating dermatitis
JP2019571619A JP6970459B2 (en) 2017-06-30 2018-06-28 Uses for improving dermatitis of compositions containing adipose-derived stem cell-derived exosomes as an active ingredient
US16/727,739 US11612621B2 (en) 2017-06-30 2019-12-26 Use of composition comprising exosome derived from adipose-derived stem cell as effective ingredient in ameliorating dermatitis

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
KR20170083506 2017-06-30
KR10-2017-0083506 2017-06-30
KR10-2017-0111179 2017-08-31
KR20170111179 2017-08-31
KR10-2018-0018617 2018-02-14
KR1020180018617A KR20190003316A (en) 2017-06-30 2018-02-14 A composition comprising an exosome and/or extracellular vesicle derived from adipose-derived stem cell as an active ingredient and its application for improving dermatitis
KR1020180062854A KR20190003336A (en) 2017-06-30 2018-05-31 A composition comprising an exosome and/or extracellular vesicle derived from adipose-derived stem cell as an active ingredient and its application for improving dermatitis
KR10-2018-0062854 2018-05-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US16/727,739 Continuation US11612621B2 (en) 2017-06-30 2019-12-26 Use of composition comprising exosome derived from adipose-derived stem cell as effective ingredient in ameliorating dermatitis

Publications (2)

Publication Number Publication Date
WO2019004738A2 WO2019004738A2 (en) 2019-01-03
WO2019004738A3 true WO2019004738A3 (en) 2019-04-11

Family

ID=64741790

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/007326 WO2019004738A2 (en) 2017-06-30 2018-06-28 Use of composition comprising adipose stem cell-derived exosome as effective ingredient in alleviating dermatitis

Country Status (1)

Country Link
WO (1) WO2019004738A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102125567B1 (en) * 2019-07-02 2020-06-22 한양대학교 에리카산학협력단 Large-Scale Production of Plant Derived Exosomes
CN111206016A (en) * 2020-01-19 2020-05-29 北京再生生物科技研究院有限公司 ADSCs conditioned medium for preventing rabbit ear acne and preparation method thereof
KR102572595B1 (en) * 2020-12-02 2023-08-31 충북대학교 산학협력단 Composition for preventing or treating anti-inflammatory diseases comprising immortalized feline mesenchymal stem cells and their exosome-rich conditoned medium

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100122087A (en) * 2008-02-22 2010-11-19 에이전시 포 사이언스, 테크놀로지 앤드 리서치 Mesenchymal stem cell particles
US20150125950A1 (en) * 2012-05-18 2015-05-07 Agency For Science, Technology And Research (A*Sta (A*Star) Umbilical cord mesenchymal stem cell exosomes
KR20160026234A (en) * 2014-08-29 2016-03-09 (주)코스메디션 Multifunctional Beauty Instrument for Percutaneous Absorption and Skin Care Method
WO2017023690A1 (en) * 2015-07-31 2017-02-09 Exoceuticals, Inc. Exosome compositions and methods for preparation and use thereof for regulating and conditioning skin and hair

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100122087A (en) * 2008-02-22 2010-11-19 에이전시 포 사이언스, 테크놀로지 앤드 리서치 Mesenchymal stem cell particles
US20150125950A1 (en) * 2012-05-18 2015-05-07 Agency For Science, Technology And Research (A*Sta (A*Star) Umbilical cord mesenchymal stem cell exosomes
KR20160026234A (en) * 2014-08-29 2016-03-09 (주)코스메디션 Multifunctional Beauty Instrument for Percutaneous Absorption and Skin Care Method
WO2017023690A1 (en) * 2015-07-31 2017-02-09 Exoceuticals, Inc. Exosome compositions and methods for preparation and use thereof for regulating and conditioning skin and hair

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOSCH, STEFFI ET AL.: "Trehalose Prevents Aggregation of Exosomes and Cryodamage", SCIENTIFIC REPORTS, vol. 6, 2016, pages 1 - 11, XP055500173, DOI: doi:10.1038/srep36162 *
See also references of EP3639832A4 *

Also Published As

Publication number Publication date
WO2019004738A2 (en) 2019-01-03

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