WO2019030833A1

WO2019030833A1 - Vibrational spectrum measurement device

Info

Publication number: WO2019030833A1
Application number: PCT/JP2017/028823
Authority: WO
Inventors: 佐藤　亮; 翔一金子
Original assignee: オリンパス株式会社
Priority date: 2017-08-08
Filing date: 2017-08-08
Publication date: 2019-02-14
Also published as: WO2019031499A1

Abstract

A vibrational spectrum measurement device (100) is provided with a long optical probe (1) for emitting illumination light toward an observation object (A) and receiving signal light generated in the observation object (A), a relative tilt measurement unit (5) for measuring a physical quantity that varies in accordance with the size of a relative tilt between the observation object (A) and the optical probe (1), a relative tilt detection unit (6) for detecting the size of the relative tilt on the basis of the physical quantity, a relative tilt determination unit (7) for determining whether the size of the relative tilt is within a predetermined allowable range, and a vibrational spectrum measurement unit (2) for measuring the vibrational spectrum of the signal light received by the optical probe (1) on the basis of the determination result.

Description

Vibration spectrum measuring device

The present invention relates to a vibration spectrum measuring apparatus.

Conventionally, abnormalities of knee joint cartilage due to arthrosis and trauma are diagnosed by nuclear magnetic resonance imaging (MRI), arthroscopy, etc. in addition to X-ray imaging and interviews. However, conventional diagnostic methods do not always have sufficient diagnostic ability for osteoarthritis of the knee, which is a major disease of the knee joint, and tissue abnormalities caused by damage to the knee joint cartilage due to trauma. In addition, in articular cartilage regeneration treatment by cultured chondrocyte transplantation, which is expected as a treatment for knee joint cartilage in the future, with conventional diagnostic methods, cartilage is regenerated as normal hyaline cartilage after cell transplantation, or fibrocartilage It is difficult to evaluate what is playing as. In order to improve the limit of such diagnostic ability, there is a need for a technology that can diagnose the condition of joint tissue including cartilage in more detail by evaluating properties such as physical or chemical characteristics of articular cartilage tissue. The nature is increasing and various technologies are being considered. As a technique for evaluating such cartilage properties, a nuclear magnetic resonance imaging (MRI) method, an ultrasonic measurement method, or an optical measurement method under arthroscopy can be mentioned.

According to optical measurement, it is possible to directly observe cartilage and bone tissue in the knee joint, and various biomolecules such as collagen and sugar chain molecules which are main components of the meniscus. Therefore, component information is acquired by an optical measurement method, and a cartilage property diagnostic technique based on the acquired component information is studied. As an optical measurement method, a fluorescence spectroscopy or photoacoustic method for observing an autofluorescence spectrum of articular cartilage, a Raman spectrum of articular cartilage (see, for example, Patent Document 1 and Non-patent Document 1) or a near infrared absorption spectrum (for example, non- There is a report on a vibrational spectrum measurement method for observing a vibrational spectrum such as in Patent Document 2.).

Regardless of which optical measurement method is used, it is difficult to optically observe articular cartilage percutaneously because light is scattered by the tissue covering the articular bone. Therefore, as shown in FIG. 26, as in the arthroscope for observing the inside of the knee joint, the skin is incised at a predetermined portal provided on the knee surface, and a thin optical probe capable of optical observation is inserted into the knee joint In some cases, access to the joint bones is required. The cartilage tissue in the surface layer of the bone is illuminated with light via an optical probe, and the spectrum of signal light from the cartilage tissue (eg, Raman scattered light or diffuse reflected light from cartilage tissue) is observed, based on the spectrum. Properties can be evaluated.

The arthroscope has a thin outer diameter of 4 mm or less, so unlike the soft mirror, the arthroscope is not provided with a forceps channel. Therefore, the arthroscope and the optical probe for observing the spectrum of tissue such as cartilage in the joint are independent capillaries, and are inserted into the joint from separate holes (portal) created on the knee surface.

Japanese Patent Publication No. 2007-524833

When measuring a vibration spectrum (for example, a Raman spectrum or an infrared absorption spectrum) of an observation target including cartilage tissue by an optical probe inserted into a knee joint, the signal-to-noise ratio of the vibration spectrum is It changes depending on the relative distance between the optical probe tip and the relative inclination. For example, as shown in FIG. 27A, when the relative inclination and relative distance between the object to be observed and the tip of the optical probe are relatively small, signal light from the object to be observed can be efficiently collected, and good vibration can be obtained. You can get a spectrum. On the other hand, as shown in FIG. 27B, when the relative inclination and relative distance between the object to be observed and the tip of the optical probe are relatively large, the collection efficiency of signal light from the object to be observed in the optical probe is lowered, and the vibration spectrum is Is degraded. Therefore, in order to obtain the vibration spectrum of the observed object having a signal-to-noise ratio sufficient for analysis, predetermined constraints exist on the relative tilt and relative distance of the optical probe with respect to the observed object.

As described above, when measuring the vibration spectrum of a good observation target having a high signal-to-noise ratio using an optical probe, it is necessary to position the optical probe with respect to the observation target with high accuracy. However, in the arthroscopic image of the arthroscope inserted into the knee joint, although it is easy to confirm the approximate position of the optical probe within the field of view, it is particularly apparent from the planar arthroscopic image, particularly in the depth direction of the image. It is not easy to determine the tilt of the optical probe. Therefore, it is usually difficult to determine whether the tilt and distance of the optical probe with respect to the observation target is appropriate based on the arthroscopic image. Under these circumstances, if the positioning of the optical probe is arbitrary, the signal-to-noise ratio may fail to make a good measurement of the vibration spectrum.

The present invention has been made in view of the above-described circumstances, and the relative inclination of the optical probe with respect to the observation target is surely set to an appropriate position when acquiring the vibration spectrum of the observation target, and then the observation target It is an object of the present invention to provide a vibration spectrum measuring apparatus capable of measuring the vibration spectrum of

In order to achieve the above object, the present invention provides the following means.
One aspect of the present invention is a long optical probe that emits illumination light from a tip end surface toward an observation target and receives signal light generated in the observation target by irradiation of the illumination light at the tip end surface, An optical probe having an illumination light path for guiding the illumination light and a focusing light path for guiding the signal light, and a physical quantity that changes according to the magnitude of relative inclination between the observation target and the optical probe A relative inclination measurement unit to measure, a relative inclination detection unit that detects the magnitude of the relative inclination based on the physical quantity measured by the relative inclination measurement unit, and the relative inclination detected by the relative inclination detection unit A relative inclination determination unit that determines whether or not the size is within a predetermined allowable range, and the guided light path of the optical probe based on the determination result by the relative inclination determination unit. It is a vibration spectrum measuring apparatus and a vibration spectrum measuring section for measuring the vibration spectrum of the signal light.

According to this aspect, the illumination light guided in the illumination light path is irradiated from the tip end surface of the optical probe to the observation target, and the signal light from the observation target (for example, the illumination light from the observation target when the illumination light is excitation light) Raman scattered light and diffuse reflected light of illumination light from the observation target are condensed by the condensing optical path on the tip surface of the optical probe, and from the signal light condensed by the condensing optical path, the vibration spectrum measuring unit The vibrational spectrum is measured.

In this case, a physical quantity that changes according to the magnitude of the relative inclination of the optical probe with respect to the observation target is measured by the relative slope measurement unit, and the relative slope detection unit detects the magnitude of the relative inclination based on the measured physical quantity. The relative tilt determining unit determines whether the magnitude of the relative tilt is within a predetermined allowable range.

When the magnitude of the relative tilt is appropriate for measuring the vibration spectrum, the magnitude of the relative tilt falls within a predetermined allowable range, and measurement of the vibration spectrum by the vibration spectrum measurement unit is performed. On the other hand, when the magnitude of the relative slope is not suitable for measuring the vibration spectrum, the magnitude of the relative slope deviates from a predetermined allowable range, and the measurement of the vibration spectrum by the vibration spectrum measurement unit is not performed. This makes it possible to measure the vibration spectrum of the observation target in a state in which the optical probe is reliably arranged at an appropriate relative inclination with respect to the observation target.

In the above aspect, a relative distance measuring unit that measures a physical quantity that changes according to the magnitude of the relative distance between the observation target and the tip surface of the optical probe, and the physical quantity measured by the relative distance measuring unit Relative distance detection unit that detects the magnitude of the relative distance based on the above, and relative distance determination that determines whether or not the magnitude of the relative distance detected by the relative distance detection unit is within a predetermined allowable range The vibration spectrum measurement unit may measure the vibration spectrum of the signal light based on the determination result by the relative tilt determination unit and the determination result by the relative distance determination unit.
In this way, measurement of the vibration spectrum can be performed with both the relative tilt and the relative distance being appropriate.

In the above aspect, the vibration spectrum determination unit evaluates the vibration spectrum measured by the vibration spectrum measurement unit and determines success or failure of the measurement of the vibration spectrum of the observation target, and reports the determination result by the vibration spectrum determination unit And a reporting unit.
By doing this, the reporting unit reports to the user whether or not a good vibration spectrum of the observation object has been measured. Therefore, the user can reliably obtain a good vibration spectrum of the observation target by repeating the measurement of the vibration spectrum until the report unit reports a successful measurement.

In the above aspect, the measurement is performed by the vibration spectrum measurement unit based on the magnitude of the relative tilt detected by the relative tilt detection unit and / or the magnitude of the relative distance detected by the relative distance detection unit. A vibration spectrum correction unit may be provided to correct the selected vibration spectrum.
In this way, variations occurring in the vibration spectrum depending on relative tilt and / or variations in relative distance, for example, variations in apparent vibration spectrum intensity can be corrected by the vibration spectrum correction unit, and the relative tilt and And / or it is possible to obtain a more quantitative vibration spectrum with reduced influence of variations in relative distance.

In the above aspect, based on the determination result by the relative tilt determination unit and / or the relative distance determination unit, the state of the light irradiated to the observation object from the illumination device that is separate from the optical probe is controlled. A lighting control unit may be provided.
When measuring the vibration spectrum of the observation object, acquire the vibration spectrum when the observation object is located in the body like the knee joint cartilage and where the optical probe is close to the observation object by visual observation It is necessary to confirm or record the position of the optical probe. In such a situation, the field of view is dark, and it is necessary to irradiate light to the object to be observed from an illuminator (arthroscope) separate from the optical probe. Under this condition, when measuring the vibration spectrum, light other than the illumination light emitted from the optical probe becomes stray light and affects the measurement result of the vibration spectrum. Therefore, at the time of measurement of the vibration spectrum, the light control unit appropriately controls the intensity and the wavelength of the light irradiated to the observation target from the illumination device by the illumination control unit to obtain a good vibration spectrum having a higher signal-to-noise ratio. Can.

In the above aspect, the relative inclination measurement unit measures the intensity of the inspection light collected by at least one of the illumination light path and the collected light path disposed on the tip surface of the optical probe, and the relative inclination detection A unit may detect the magnitude of the relative inclination based on the intensity of the inspection light measured by the relative inclination measurement unit. Further, the relative distance measurement unit measures the intensity of the inspection light collected by at least one of the illumination light path and the collection light path disposed on the tip surface of the optical probe, and the relative distance detection unit The magnitude of the relative distance may be detected based on the intensity of the inspection light measured by the relative distance measurement unit.
By doing this, the relative inclination and the relative distance can be optically detected based on the intensity of the inspection light as a physical quantity.

In the above aspect, the relative inclination measurement unit has a plurality of inspection light paths provided on the optical probe and different from the illumination light path and the collection light path, and the plurality of inspection light paths are provided on the tip surface of the optical probe. The intensities of the plurality of inspection lights respectively collected are measured, and the relative inclination detection unit detects the relative inclination based on the difference between the intensities of the plurality of inspection lights measured by the relative inclination measurement unit. May be Further, the relative distance measurement unit has a plurality of inspection light paths provided in the optical probe and different from the illumination light path and the collection light path, and the light is collected by the plurality of inspection light paths on the tip surface of the optical probe. The relative distance detection unit may detect the relative distance based on the magnitude of the intensity of the plurality of inspection lights measured by the relative distance measurement unit. .
The intensities of the plurality of inspection lights collected by the inspection light path at a plurality of positions on the tip surface of the optical probe depend on the relative tilt and relative distance of the optical probe with respect to the observation target. Therefore, the relative inclination can be detected based on the difference between the intensities of the plurality of inspection lights, and the relative distance can be detected based on the magnitudes of the intensities of the plurality of inspection lights.

In the above aspect, the optical probe has a plurality of the condensing light paths, and the relative inclination measurement unit is directed from the illumination optical path of the optical probe to an object facing the tip surface of the optical probe. Is emitted, and the intensities of the plurality of inspection lights reflected by the object and collected by the plurality of collected light paths are measured, and the relative tilt detection unit measures the plurality of measured by the relative tilt measurement unit. The relative inclination may be detected based on the difference between the intensities of the inspection light. In addition, the optical probe has a plurality of condensing light paths, and the relative distance measurement unit emits inspection light toward the object facing the tip surface of the optical probe from the illumination light path of the optical probe. Measuring the intensities of the plurality of inspection lights reflected by the object and collected by the plurality of collection light paths, and the relative distance detection unit measures the plurality of inspection lights measured by the relative distance measurement unit The relative distance may be detected based on the magnitude of the intensity of
In this way, the inspection light can be irradiated to the object using the illumination light path common to the illumination light, and the inspection light from the object is condensed using the condensing light path common to the signal light can do.

In the above aspect, the optical probe has a plurality of the condensing light paths, and the inspection light is endoscope illumination light emitted from the endoscope to the observation target, and the relative inclination measurement unit And measuring the intensities of the plurality of inspection lights reflected by the observation target and collected by the plurality of collection light paths, and the relative inclination detection unit measures the plurality of inspections measured by the relative inclination measurement unit. The relative tilt may be detected based on the difference between the light intensities. In addition, the optical probe has a plurality of the condensing light paths, and the inspection light is endoscope illumination light irradiated from the endoscope to the observation target, and the relative distance measurement unit is the observation. The intensities of the plurality of inspection lights reflected by the object and collected by the plurality of collected light paths are measured, and the relative distance detection unit measures the intensities of the plurality of inspection lights measured by the relative distance measurement unit. The relative distance may be detected based on the magnitude of.
In this way, endoscope illumination light of an endoscope for optically observing an observation target can be used as examination light.

In the above aspect, the plurality of inspection light paths may be configured of a fiber Bragg grating (FBG).
When the tip surface of the optical probe is brought into contact with the object to be observed, distortion occurs according to the relative inclination and relative distance at the tip of the FBG, and a change occurs in the intensity of inspection light guided in the FBG. Therefore, relative inclination and relative distance can be detected based on the intensities of the plurality of inspection lights guided by the plurality of FBGs.

In the above aspect, the vibration spectrum measurement unit may include a light source that generates the illumination light, and the inspection light may be the illumination light generated by the light source of the vibration spectrum measurement unit.
By doing this, it is not necessary to add a light source for generating inspection light.

In the above aspect, the vibration spectrum measurement unit includes a light detector that detects the illumination light, and the relative tilt measurement unit and / or the relative distance measurement unit is the light detector of the vibration spectrum measurement unit. The intensity of the inspection light may be measured.
By doing this, it is not necessary to add a light detector for measuring the inspection light.

In the above aspect, the object may be the observation target.
In the above aspect, the object may be a partition that is connected to the tip end surface of the optical probe via an elastic body and is applied to the observation target and reflects at least a part of the inspection light. Good.
When the tip surface of the optical probe is brought into contact with the observation target via the partition wall, the inclination of the partition wall changes according to the relative inclination between the optical probe and the observation target, and the distance between the optical probe and the observation target The position of the partition changes according to the relative distance. In this case, the intensity of the inspection light reflected by the partition wall and collected in the condensing optical path changes. Therefore, based on the intensity of the inspection light, the relative tilt and relative distance between the optical probe and the observation target can be detected.

In the above aspect, the partition may be a long wavelength transmission filter that transmits the illumination light and reflects the inspection light having a wavelength shorter than that of the illumination light.
In this way, inspection light of a wavelength different from that of the illumination light can be used.

In the above aspect, the light source of the vibration spectrum measurement unit generates excitation light for generating the Raman scattered light of the observation target as the illumination light, and the light detector of the vibration spectrum measurement unit is the observation target A Raman spectrum may be measured, and the inspection light may be the excitation light, and the photodetector may detect the inspection light.
By doing this, it is not necessary to add a light source for generating inspection light and a light detector for detecting the inspection light.

In the above aspect, the relative inclination measurement unit includes a plurality of contact pressure sensors arranged on the tip surface of the optical probe, and the relative inclination detection unit is measured by the plurality of contact pressure sensors. The magnitude of the relative inclination may be detected based on the difference between the plurality of pressures. Further, the relative distance measurement unit includes a plurality of contact pressure sensors arranged on the tip surface of the optical probe, and the relative distance detection unit includes a plurality of contacts measured by the plurality of contact pressure sensors. The relative distance may be detected based on the magnitude of pressure.
By doing this, when the tip surface of the optical probe is brought into contact with the observation target, the pressures acting on the plurality of positions on the tip surface of the optical probe from the observation target are measured by the plurality of contact pressure sensors. The pressure measured by the contact pressure sensor at each position depends on the relative tilt and relative distance. Thus, relative tilt and relative distance can be detected based on the pressure at multiple locations on the tip surface of the optical probe.

In the above aspect, the plurality of contact-type pressure sensors may be uniformly arranged in the circumferential direction around the illumination light path of the optical probe and the collection light path.
In this way, relative tilt and relative distance can be detected more accurately based on the plurality of pressures measured by the plurality of contact pressure sensors.

In the above aspect, the contact pressure sensor may be a capacitive pressure sensor or a piezoelectric sensor.
By doing this, it is possible to measure a voltage having a magnitude corresponding to the pressure as a physical quantity.

In the above aspect, the relative inclination measurement unit and the relative distance measurement unit emit ultrasonic waves and receive the reflected waves of the ultrasonic waves from the observation target and the optical probe, and based on the received reflected waves. The ultrasonic inspection apparatus for measuring the distance to each position of the observation object and the optical probe is provided, and the relative inclination detection unit and the relative distance detection unit are the observation object and the measurement measured by the ultrasonic inspection apparatus. The relative tilt and the relative distance may be detected based on the distance to each position of the optical probe. The ultrasonic inspection apparatus may be attached to an endoscope for observing the observation target.
By doing this, the position of the surface of the observation target and the surface of the optical probe can be estimated based on the distance to the observation target and the optical probe measured by the ultrasonic inspection apparatus, and the estimated observation target The relative tilt and relative distance can be detected from the surface of and the position of the surface of the optical probe.

According to the present invention, the relative inclination of the optical probe with respect to the observation target can be measured with the vibration spectrum of the observation target after being surely set to an appropriate arrangement when acquiring the vibration spectrum of the observation target. Play.

BRIEF DESCRIPTION OF THE DRAWINGS It is a whole block diagram of the vibration spectrum measuring apparatus which concerns on the 1st Embodiment of this invention. It is an internal block diagram of the vibration spectrum measurement part in the vibration spectrum measuring apparatus of FIG. 1, a vibration spectrum determination part, a report part, a relative inclination determination part, and a relative distance determination part. It is a longitudinal cross-sectional view which shows the internal structure of an optical probe. It is a figure which shows arrangement | positioning of the illumination optical path in the front end surface of an optical probe, and a condensing optical path. It is a figure which shows arrangement | positioning of the condensing optical path in the proximal end of an optical probe. FIG. 5 is a diagram showing a point image array of single wavelength light collected by the collection optical path of the optical probe formed on the light receiving surface of the light detector. It is a figure which shows the point-image arrangement | sequence of the multi-wavelength light collected by the condensing optical path of an optical probe formed on the light-receiving surface of a photodetector. It is a figure explaining the intensity distribution of the inspection light acquired by a photodetector, when the relative inclination of the optical probe to observation object is unsuitable in measuring the vibration spectrum of observation object. It is a figure explaining intensity distribution of inspection light acquired by a photodetector when relative distance of an optical probe to observation object is unsuitable in measuring a vibration spectrum of observation object. It is a figure explaining the intensity distribution of the inspection light acquired by a photodetector, when the relative inclination and relative distance of an optical probe to observation object are suitable in measuring the vibration spectrum of observation object. It is an example of the vibration spectrum of the biological tissue (articular cartilage) measured by the vibration spectrum measurement part. It is an example of reference spectrum data of a living tissue (articular cartilage) stored in the storage device of the vibration spectrum measurement unit. It is a figure which shows the suitable arrangement | positioning of the optical probe with respect to observation object. It is a figure which shows the unsuitable arrangement | positioning of the optical probe with respect to observation object. It is a graph showing an example of the relation between the relative inclination of the optical probe to the observation object and the maximum intensity difference of the inspection light detected by the relative inclination detection unit. It is a graph showing an example of the relation between the relative distance of the optical probe to the observation object and the total inspection light intensity detected by the relative distance detection unit. It is a flowchart which shows operation | movement of the vibration spectrum measuring apparatus of FIG. It is a block diagram of the modification of a vibration spectrum measurement part, a relative inclination measurement part, and a relative distance measurement part. It is sectional drawing of the modification of the optical probe which has an elastic body and a partition in a front-end | tip part. It is a figure which shows an example of arrangement | positioning of the elastic body in the front end surface of an optical probe. It is a figure which shows the other example of arrangement | positioning of the elastic body in the front end surface of an optical probe. It is a figure which shows the modification of the vibration-spectrum measuring apparatus of FIG. It is a block diagram of the modification of the optical probe in which the fiber Bragg grating was provided. It is a figure which shows the connection of the fiber Bragg grating of FIG. 13A, a test | inspection light source, and a photodetector. It is a block diagram of the other modification of the optical probe in which the fiber Bragg grating was provided. It is a whole block diagram of the vibration spectrum measuring apparatus which concerns on the 2nd Embodiment of this invention. It is a block diagram of the front-end | tip part of the optical probe of FIG. It is a block diagram of the front-end | tip part of the optical probe of FIG. It is a block diagram of the pressure sensor part provided in the front end surface of the optical probe of FIG. It is a block diagram of the electrostatic capacitance type pressure sensor of the pressure sensor part of FIG. It is a figure explaining the bias of pressure measured by a plurality of pressure sensors when relative inclination is unsuitable. It is a figure explaining the least square plane computed by the relative inclination detection part and relative distance detection part of a vibration spectrum measuring device of FIG. It is a block diagram of a piezoelectric sensor. It is a whole block diagram of the vibration spectrum measuring apparatus which concerns on the 3rd Embodiment of this invention. It is a figure explaining the ultrasonic wave inject | emitted from the ultrasonic inspection apparatus of FIG. FIG. 23 is a diagram for explaining a three-dimensional estimated peripheral model created by the relative tilt detection unit and the relative distance detection unit of the vibration spectrum measuring apparatus of FIG. 21. It is a whole block diagram of the modification of the vibration spectrum measuring apparatus which concerns on the 1st to 3rd embodiment. It is a whole block diagram of the other modification of the vibration spectrum measuring apparatus which concerns on the 1st-3rd embodiment. It is a figure explaining arrangement | positioning of the arthroscope and optical probe which are inserted in a knee joint. It is a figure which shows an example of arrangement | positioning of the optical probe with respect to observation object. It is a figure which shows the other example of arrangement | positioning of the optical probe with respect to observation object.

First Embodiment
A vibration spectrum measuring apparatus 100 according to a first embodiment of the present invention will be described with reference to the drawings.
As shown in FIG. 1, the vibration spectrum measuring apparatus 100 according to the present embodiment is thin and long, which is inserted in a joint and emits illumination light to the observation target A and receives signal light from the observation target A. Of the optical probe 1, the vibration spectrum measuring unit 2 for measuring the vibration spectrum of the signal light received by the optical probe 1, the vibration spectrum judging unit 3 for judging success or failure of the measurement of the vibration spectrum, and the vibration spectrum judging unit 3 And a reporting unit 4 for reporting the determination result to the user. FIG. 2 shows the internal configuration of the vibration spectrum measurement unit 2, the vibration spectrum determination unit 3, and the report unit 4.

As shown in FIG. 3A, the optical probe 1 incorporates an illumination light path 1A for guiding illumination light for illuminating the observation target A and a collection light path 1B for guiding signal light from the observation target A. doing. The signal light is, for example, Raman scattered light generated in the observation target A when the illumination light is irradiated as excitation light, or diffused reflected light reflected from tissue when the illumination light is irradiated to the observation target. The illumination light path 1A and the collection light path 1B are optical fibers disposed in the optical probe 1 along the longitudinal direction, and the tip surface of each optical fiber is disposed on the tip surface of the optical probe 1. On the tip surface of the optical probe 1, as shown in FIG. 3B, the plurality of collected light paths 1B are arranged at equal intervals along the circumferential direction around the illumination light path 1A. Alternatively, the plurality of collection light paths 1B are arranged around the illumination light path 1A. At the proximal end of the optical probe 1, as shown in FIG. 3C, the plurality of focusing optical paths 1B are arranged in a line.

The vibration spectrum measurement unit 2 is optically connected to the illumination light path 1A and the collection light path 1B extending from the proximal end of the optical probe 1 through the coupling

optical systems

22A and 22B. As shown in FIG. 2, the vibration spectrum measurement unit 2 is incident from the light source 21 that generates illumination light, the coupling optical system 22A that optically connects the light source 21 and the illumination light path 1A, and the condensing light path 1B. The spectrum of the signal light separated for each wavelength by the spectroscope 23 is detected by the spectroscope 23 for separating the signal light, the coupling optical system 22B which optically connects the condensing optical path 1B and the spectroscope 23, and A light detector 24 for acquiring data of a vibration spectrum of an observation object, a storage device 25 for storing data of the vibration spectrum acquired by the light detector 24, a light source 21, a spectroscope 23, and a light detector 24 are controlled. And a control device 26.

The light source 21 is either a monochromatic laser light source or a laser light source capable of wavelength sweeping, and has illumination light of a wavelength according to the measurement of the vibration spectrum (for example, Raman spectrum, infrared absorption spectrum, or near infrared absorption spectrum) of the measurement object. Occur. When the light source 21 generates excitation light for generating the Raman scattered light of the observation target A, the light source 21 is a diode laser which generates a laser beam of a single wavelength. Alternatively, the light source 21 may be a wide wavelength band infrared light source such as a thermal light source or a supercontinuum light source.
The coupling optical system 22A includes, for example, one or more lenses for condensing the illumination light emitted from the light source 21 on the proximal end surface of the optical fiber constituting the illumination light path 1A.

The coupling optical system 22B is, for example, a signal light emitted from the proximal end of the condensing optical path 1B, and includes a pair of lenses whose focal points are disposed at the base end face of the optical fiber constituting the condensing optical path 1B and the spectroscope 23, respectively. Are imaged at the position of the strip-like entrance slit of the spectroscope 23. When measuring the Raman spectrum as the vibration spectrum of the observation target, the illumination light for exciting the Raman scattering of the observation target is removed at the middle position of the pair of lenses of the coupling optical system 22B, so it is longer than the illumination light. An optical filter is provided to selectively transmit wavelength light.
The spectroscope 23 spatially separates the signal light incident from the condensing optical path 1 B for each wavelength, and forms an image of the obtained spectrum on the light receiving surface 24 a of the light detector 24.

The light detector 24 is a two-dimensional light detector such as a two-dimensional CCD image sensor, and has a light receiving surface 24 a in which a large number of photoelectric conversion elements are two-dimensionally arranged. The photodetector 24 converts the light incident on the light receiving surface 24 a from the spectroscope 23 into an electrical signal by the photoelectric conversion element, and acquires data of the vibration spectrum.

At the proximal end of the optical probe 1, the plurality of focusing optical paths 1 </ b> B are aligned in the same direction as the long axis of the entrance slit of the spectroscope 23. Here, it is assumed that inspection light of a single wavelength reflected from the observation target A is incident on the tip surface of the optical probe 1, and the inspection light is condensed by the plurality of condensing optical paths 1B. The inspection light is emitted from the proximal ends of the plurality of condensing light paths 1B, and then aligned in a line and enters the entrance slit of the spectroscope 23. The plurality of inspection lights emitted from the spectroscope 23 are imaged as a plurality of point images S aligned in a line on the light receiving surface 24 a of the light detector 24 as shown in FIG. 4A. Here, the horizontal axis is the wavelength channel of the light detector 24, the vertical axis is the position channel, and the intensity of the point image S is the inspection light intensity. As described above, the images of the inspection light condensed by the plurality of condensing optical paths 1B are spatially separated from each other on the light receiving surface 24a, whereby the intensity of the inspection light guided for each of the condensing optical paths 1B Data is acquired.
In addition, when signal light from the observation target A is incident on the tip surface of the optical probe 1 and the signal light is light including a plurality of wavelength components as in Raman scattered light, as shown in FIG. 4B. The signal light is imaged as a point image SS aligned in the wavelength channel direction and the position channel direction on the light receiving surface 24 a of the light detector 24. Thus, the signal light condensed by the plurality of condensing optical paths 1B is spatially separated from each other on the light receiving surface 24a, whereby vibration spectrum data of the signal light guided for each of the condensing optical paths 1B Is acquired. Here, even if vibration spectrum data for each collected light path 1B is acquired, data in which vibration spectrum data for each collected light path 1B are collectively obtained may be acquired.

In the storage device 25, as shown in FIGS. 5A to 5C, data (left row) in which the wavelength of the inspection light guided for each of the condensing optical paths 1B is associated with the position of the condensing optical path 1B; Data (right row) in which the intensity of each inspection light is associated with the position of the collected light path 1B is stored. In the left steps of FIGS. 5A to 5C, the horizontal axis is the wavelength, and the vertical axis is the position of the condensing optical path 1B. In the right steps of FIGS. 5A to 5C, the horizontal axis is the intensity of the inspection light, and the vertical axis is the position of the condensing optical path 1B.
The control device 26 mechanically controls the rotation angle of the diffraction grating built in the spectroscope 23 and the entrance slit width, and electrically controls the setting of the light detector. The control device 26 detects the emitted light intensity of the light source 21, the central wavelength or the entrance slit width of the diffraction grating of the spectroscope 23, and the light detection based on the determination results by the relative inclination determination unit 7 and the relative distance determination unit 10 described later. The measurement of the vibration spectrum of the observation target A is performed after changing the gain of the unit 24 and the exposure time as necessary.

As shown in FIG. 2, the vibration spectrum determination unit 3 includes a storage device 3A and an arithmetic device 3B.
The data of the vibration spectrum is read from the storage unit 25 of the vibration spectrum measurement unit 2 and stored in the storage unit 3 A of the vibration spectrum determination unit 3. In the storage device 3A, a plurality of typical vibration spectra of the observation target A (for example, articular cartilage) are stored in advance as reference spectrum data. FIG. 6A shows an example of the vibration spectrum measured by the vibration spectrum measurement unit 2, and FIG. 6B shows an example of reference spectrum data.

Arithmetic device 3B evaluates the vibration spectrum by comparing the vibration spectrum newly stored in storage device 3A with the reference spectrum, and if the vibration spectrum is similar to the reference spectrum, the vibration spectrum of observation object A It is determined that the measurement is successful, and if the vibration spectrum is not similar to the reference spectrum, it is determined that the measurement of the vibration spectrum of the observation target A has failed. The comparison between the vibration spectrum and the reference spectrum is performed based on any one or a combination of the spectrum waveform, the sum of intensities of the spectrum, the signal-to-noise ratio, or the feature quantity of the spectrum waveform. For example, as shown in FIGS. 6A and 6B, the relative intensities of specific Raman bands I, II of articular cartilage being observed A are compared. The Raman band I is a Raman band of proline of collagen which is an articular cartilage component, and the Raman band II is a Raman band of the polypeptide backbone of collagen which is an articular cartilage component. The vibration spectrum determination unit 3 transmits the determination result, that is, the success or failure of measurement of the vibration spectrum to the report unit 4.

As shown in FIG. 2, the reporting unit 4 includes an output device 41 such as a display for outputting a display or a speaker for outputting a sound. The reporting unit 4 reports the success or failure of the spectrum measurement to the user by outputting from the output device 41 a display or a voice corresponding to the success or failure of the measurement of the vibration spectrum.

Furthermore, as shown in FIG. 1, the vibration spectrum measuring apparatus 100 includes the relative inclination measuring unit 5, the relative inclination detecting unit 6, the relative inclination determining unit 7, the relative distance measuring unit 8, and the relative distance detecting unit 9. And the relative distance determination unit 10.
The relative inclination and relative distance of the optical probe 1 with respect to the observation target A relate to the success or failure of measurement of the vibration spectrum by the vibration spectrum measurement unit 2. Therefore, relative inclination measurement unit 5, relative inclination detection unit 6, and relative inclination determination unit 7 determine whether or not the relative inclination is appropriate, and relative distance measurement unit 8, relative distance detection unit 9, and relative distance The determination unit 10 determines whether the relative distance is appropriate.

7A and 7B illustrate the relative tilt and relative distance of the optical probe 1 with respect to the observation target A. FIG. The relative inclination is an angle θ formed by the vertical line on the surface of the observation object A and the perpendicular line of the front surface of the optical probe 1 at the intersection of the perpendicular line on the front surface of the optical probe 1 and the surface of the observation object A. The relative distance is the distance between the tip surface of the optical probe 1 and the surface of the observation target A.

FIG. 7A shows an example of the arrangement of the optical probe 1 suitable for measuring the vibration spectrum. As shown in FIG. 7A, when the relative inclination and the relative distance are small, when the illumination light is irradiated to the observation target A, the signal light reflected from the observation target A is efficiently collected by the condensing optical path 1B. Thus, a good vibration spectrum with a high signal to noise ratio can be obtained.
On the other hand, FIG. 7B shows an example of the arrangement of the optical probe 1 unsuitable for measurement of the vibration spectrum. As shown in FIG. 7B, when the relative inclination and the relative distance are large, when the illumination light is irradiated to the observation target A, the condensing efficiency of the signal light reflected from the observation target A by the condensing optical path 1B is As the signal-to-noise ratio of the vibration spectrum is lowered, the good vibration spectrum can not be obtained.

The relative inclination measurement unit 5 includes a light source for generating an inspection light for measuring the relative inclination, a plurality of inspection light paths for condensing and guiding the inspection light reflected by the observation target A, and a plurality of inspection light paths. And a light detector for detecting the guided inspection light.
The light source is the light source 21 in the vibration spectrum measuring unit 2, the inspection light path is the condensing light path 1 B, and the light detector is the light detector 24 for vibration spectrum measurement mounted in the vibration spectrum measuring unit 2. . That is, the illumination light for measuring the vibration spectrum of the observation target A also serves as the inspection light, and the intensities (physical quantities) of the plurality of inspection lights are detected by the light detector 24 in the same manner as the signal light.
As the inspection light path, the illumination light path 1A may be used, or both the illumination light path 1A and the collection light path 1B may be used.

The relative tilt detection unit 6 detects the magnitude of the relative tilt of the optical probe 1 with respect to the observation target A based on the differences in the intensities of the plurality of inspection lights measured by the relative tilt measurement unit 5.
Specifically, as shown in FIGS. 5A and 5C, according to the relative inclination between the observation target A and the optical probe 1, the intensity distribution of the inspection light collected by the plurality of collected light paths 1B The intensity profile changes. That is, when the relative inclination of the optical probe 1 with respect to the observation target A is large and unsuitable for vibration spectrum measurement, as shown in FIG. 5A, the intensities of the plurality of inspection lights collected by the plurality of collected light paths 1B. As a result, the difference between the maximum value and the minimum value (maximum intensity difference) among the intensities of the plurality of inspection lights increases. On the other hand, when the relative inclination of the optical probe 1 with respect to the observation target A is small and appropriate for vibration spectrum measurement, the intensity of the inspection light collected by all the collection light paths 1B is as shown in FIG. 5C. It becomes almost even, and the maximum intensity difference becomes smaller. FIG. 8A shows the relationship between the relative inclination of the optical probe 1 with respect to the observation target A and the maximum intensity difference of a plurality of inspection lights. The relative inclination detection unit 6 includes an arithmetic device (not shown), and detects the maximum intensity difference as the magnitude of the relative inclination from the intensities of the plurality of inspection lights by the arithmetic operation of the arithmetic device.

As shown in FIG. 2, the relative inclination determination unit 7 includes a storage device 7A and an arithmetic device 7B. In the storage device 7A, the maximum intensity difference detected by the relative inclination detection unit 6 under each of the conditions under which the relative inclination is appropriate and the conditions under which the relative inclination is inappropriate is stored in advance as reference data. The arithmetic device 7B compares the maximum intensity difference detected by the relative inclination detection unit 6 with the reference data, so that the relative inclination of the optical probe 1 with respect to the current observation object A is appropriate for measuring the vibration spectrum of the observation object A. Determine if there is.

Specifically, as shown in FIG. 8A, data of the maximum intensity difference of the inspection light when the relative inclination of the observation object and the optical probe is an arbitrary value is acquired in advance, and the vibration spectrum of the observation object A Among the relative inclinations suitable for measurement, the maximum intensity difference (= T1) detected by the relative inclination detection unit 6 at the maximum relative inclination is set in advance as a threshold, and the allowable range of the relative inclination is less than the threshold T1. A range is set. The relative inclination determination unit 7 determines that the relative inclination of the observation target A and the optical probe 1 is appropriate when the current maximum intensity difference is equal to or less than the threshold T1, and the maximum intensity difference of the current inspection light is the threshold T1. If the relative inclination between the observation target A and the optical probe 1 is larger, the relative inclination between the observation target A and the optical probe 1 is determined to be unsuitable.

The relative inclination determination unit 7 is electrically connected to the control device 26 and the report unit 4 of the vibration spectrum measurement unit 2. The determination result by the relative inclination determination unit 7 is transmitted to the control device 26 and the report unit 4 of the vibration spectrum measurement unit 2.

The relative distance measurement unit 8 includes a light source generating inspection light for measuring the relative distance, a plurality of inspection light paths for condensing and guiding the inspection light reflected by the observation target A, and a plurality of inspection light paths. And a light detector for detecting the guided inspection light.
Similar to the relative inclination measurement unit 5, the light source is the light source 21 in the vibration spectrum measurement unit 2, the inspection light path is the condensing light path 1 B, and the light detector is for vibration spectrum measurement in the vibration spectrum measurement unit 2. It is a light detector 24.

The relative distance detection unit 9 detects the magnitude of the relative distance of the optical probe 1 with respect to the observation target A based on the magnitudes of the intensities of the plurality of inspection lights measured by the relative distance measurement unit 8.
Specifically, as shown in FIGS. 5B and 5C, according to the relative distance between the observation target A and the optical probe 1, the magnitude of the intensity of the inspection light collected by the plurality of collected light paths 1B. Changes as a whole. That is, when the relative distance is large and unsuitable for vibration spectrum measurement, as shown in FIG. 5B, the sum of the intensities of a plurality of inspection lights condensed by a plurality of condensing optical paths 1B (all inspection light intensities) Becomes smaller. On the other hand, when the relative distance between the observation target A and the optical probe 1 is small and appropriate for vibration spectrum measurement, as shown in FIG. 5C, the total inspection light intensity is large. FIG. 8B shows the relationship between the relative distance and the total inspection light intensity. The relative distance detection unit 9 includes an arithmetic unit (not shown), and detects the total inspection light intensity as the magnitude of the relative distance from the intensities of the plurality of inspection lights by the arithmetic operation of the arithmetic unit.

As shown in FIG. 2, the relative distance determination unit 10 includes a storage device 10A and an arithmetic device 10B. In the storage device 10A, all inspection light intensities detected by the relative distance detection unit 9 under the conditions under which the relative distance between the observation object A and the optical probe 1 is appropriate and under conditions are stored in advance as reference data. There is. Arithmetic device 10B determines whether the current relative distance is appropriate for measuring the vibration spectrum of observation object A by comparing the total inspection light intensity detected by relative distance detection unit 9 with the reference data. .

Specifically, as shown in FIG. 8B, data of the total inspection light intensity when the relative distance between the observation object and the optical probe is an arbitrary value is acquired in advance, and the measurement of the vibration spectrum of the observation object A is performed. Of the appropriate relative distances, all inspection light intensities (= T2) detected by the relative distance detection unit 9 at the maximum relative distance are preset as a threshold, and a range of the threshold T2 or more as an allowable range of the relative distance Is set. The relative distance determination unit 10 determines that the relative distance between the observation target A and the optical probe 1 is appropriate when the current total inspection light intensity is equal to or greater than the threshold T2, and the current total inspection light intensity is greater than the threshold T2. If the distance between the observation target A and the optical probe 1 is too small, it is determined that the relative distance between the observation target A and the optical probe 1 is inappropriate.

The relative distance determination unit 10 is electrically connected to the control device 26 and the report unit 4 of the vibration spectrum measurement unit 2. The determination result by the relative distance determination unit 10 is transmitted to the control device 26 and the report unit 4 of the vibration spectrum measurement unit 2.

The control device 26 of the vibration spectrum measurement unit 2 has an appropriate relative tilt of the optical probe 1 with respect to the observation target A based on the determination results received from the relative tilt determination unit 7 and the relative distance determination unit 10, and the observation target Only when the relative distance of the optical probe 1 with respect to A is appropriate, measurement of the vibration spectrum of the observation object A is performed.

When it is determined that at least one of the relative inclination and the relative distance is not appropriate, the reporting unit 4 reports or informs the user by display or sound. After the user adjusts the position and tilt of the optical probe 1 in response to the report from the report unit 4, the relative tilt and the relative distance are again determined by the

determination units

7 and 10. The user repeats the adjustment of the position and tilt of the optical probe 1 until the report unit 4 reports that both the relative tilt and relative distance of the optical probe 1 are appropriate.

Next, the operation of the vibration spectrum measuring apparatus 100 configured as described above will be described.
According to the vibration spectrum measuring apparatus 100 according to the present embodiment, as shown in FIG. 9, relative to the observation object A of the optical probe 1 inserted in the joint prior to the measurement of the vibration spectrum of the observation object A. It is determined whether the inclination and the relative distance are appropriate (steps SA1 to SA6).

Specifically, inspection light for measuring relative inclination and relative distance is emitted from the light source 21 by operation of the relative inclination measurement unit 5 and the relative distance measurement unit 8, and is guided in the illumination light path 1A to be observed A Irradiated. The inspection light reflected on the observation target A is condensed by the plurality of condensing optical paths 1B on the tip surface of the optical probe 1, and is guided by the condensing optical path 1B, the coupling optical system 22B, and the spectroscope 23 for light detection Is detected by the sensor 24. The relative inclination detection unit 6 and the relative distance detection unit 9 respectively detect the maximum intensity difference and the total inspection light intensity from the intensities of the plurality of inspection lights detected by the light detector 24 (steps SA1, SA2).

Next, in measuring the vibration spectrum of the observation object A by the relative inclination determination unit 7, whether or not the relative inclination is appropriate is determined based on the maximum intensity difference, and the relative distance determination unit 10 observes In measuring the vibration spectrum of the object A, it is determined based on the total inspection light intensity whether the relative distance is appropriate (step SA3). If at least one of the relative inclination and the relative distance is not appropriate (NO in step SA4), the report unit 4 reports that effect (step SA5), and returns to step SA1. On the other hand, if both the relative inclination and the relative distance are appropriate (YES in step SA4), the report unit 4 reports that effect (step SA6), and the controller 26 of the vibration spectrum measurement unit 2 is used as needed. After setting the output light beam intensity of the light source 21, the central wavelength of the diffraction grating of the spectroscope 23, the gain of the light detector 24 and the exposure time to predetermined values, measurement of the vibration spectrum of the observation object A is started (step SA7).

The vibration spectrum measurement unit 2 generates illumination light from the light source 21, and the illumination light is guided to the illumination light path 1 A in the optical probe 1 and is irradiated to the observation target A. Signal light such as Raman scattering light or diffuse reflection light generated in the observation target A is collected by the plurality of collection light paths 1B in the optical probe 1, dispersed by the spectroscope 23, and the spectrum of the signal light is detected by the photodetector 24 is detected. As a result, the vibration spectrum of the signal light condensed by each of the condensing optical paths 1B is obtained by the photodetector 24 (step SA8).

Next, it is determined by the vibration spectrum determination unit 3 whether or not the measurement of the vibration spectrum of the observation object A is successful (step SA9). If the measurement of the vibration spectrum of the observation target A fails (NO in step SA10), the report unit 4 reports that effect (step SA11), and returns to step SA1. On the other hand, if the measurement of the vibration spectrum of the observation target A is successful (YES in step SA10), the report unit 4 reports that (step SA12), and the measurement of the vibration spectrum ends.

Thus, according to the present embodiment, prior to the measurement of the vibration spectrum of the observation object A, the relative inclination and the relative distance of the optical probe 1 with respect to the observation object A are detected, and in measuring the vibration spectrum, the relative inclination and It is determined whether the relative distance is appropriate. The measurement of the vibrational spectrum is then performed only when both the relative tilt and the relative distance are appropriate. Thereby, the vibration spectrum can be measured in a state in which the optical probe 1 is disposed at an appropriate relative inclination and relative distance with respect to the observation target A, and a good vibration spectrum having a high signal-to-noise ratio can be obtained. It has the advantage of being able to

In the present embodiment, as the inspection light for measuring the relative inclination and the relative distance, the illumination light for measuring the vibration spectrum is used, but instead, light different from the illumination light may be used . That is, as shown in FIG. 10, the relative inclination measurement unit 5 and the relative distance measurement unit 8 may be provided with the inspection light source 11 dedicated to inspection light different from the light source 21.
In this case, a light source switching device that switches the optical path between the coupling optical system 22A and the

light sources

11 and 21 so that the illumination light and the inspection light are alternatively guided to the coupling optical system 22A and the illumination optical path 1A. 27 are provided.
In addition, the relative inclination measurement unit 5 and the relative distance measurement unit 8 may each include an inspection light source dedicated to relative inclination measurement and an inspection light source dedicated to relative distance measurement, instead of the common inspection light source 11.

In the present embodiment, the relative distance measurement unit 8, the relative distance detection unit 9, and the relative distance determination unit 10 may not necessarily be provided. In this case, the control device 26 of the vibration spectrum measurement unit 2 measures the vibration spectrum based only on the determination result by the relative tilt determination unit 7.
The relative distance between the observation object A and the optical probe 1 can be relatively easily confirmed from the image of the arthroscope used with the optical probe 1, but the relative tilt of the observation object A and the optical probe 1 The relative inclination of the image in the depth direction is difficult to confirm from a two-dimensional arthroscopic image. Therefore, detection and determination of the relative tilt can effectively assist the user in properly arranging the optical probe 1 in measuring the vibration spectrum of the observation target A.

In the present embodiment, the relative inclination and the relative distance are measured based on the inspection light reflected by the observation target A, but instead, as shown in FIGS. 11A to 11C, the optical probe 1 The relative inclination and the relative distance may be measured based on the inspection light reflected by the partition 12 provided at the tip of the.
That is, a partition 12 disposed opposite to the tip end surface of the optical probe 1 and placed against the observation target A, and disposed between the tip end surface of the optical probe 1 and the partition 12, An elastic body 13 connecting to the partition wall 12 is provided on the tip surface of the optical probe 1.

The partition 12 is placed parallel to the tip surface of the optical probe 1 as shown in FIG. 11A, and all or a part of the inspection light is reflected by the partition 12 and most components of the illumination light and signal light are the partition 12 It is supposed to be transparent. In addition, elastic bodies 13 of equal thickness are evenly distributed in the circumferential direction of the optical probe 1 so that the flat surface of the partition wall 12 is parallel to the tip surface of the optical probe 1. For example, as shown in FIG. 11B, a plurality of elastic bodies 13 are arranged at equal intervals in the circumferential direction, or as shown in FIG. 11C, an annular elastic body 13 is used.

The partition 12 is an optically transparent plate such as sapphire or quartz glass, and reflects a part of the inspection light emitted from the illumination light path 1A. The inspection light reflected by the partition 12 is collected by the collection light path 1B.
When the partition wall 12 is brought into contact with the observation target A, the elastic body 13 is elastically deformed in the direction along the longitudinal axis of the optical probe 1 by the pressure from the observation target A. The inclination and distance of the partition wall 12 with respect to the tip surface of the optical probe 1 change according to the relative inclination and the relative distance. As a result, in accordance with the relative inclination, a bias occurs between the intensities of the inspection light collected by the plurality of collected light paths 1B, and the light amount of the inspection light collected by the plurality of collected light paths 1B is overall according to the relative distance. Change to Therefore, the relative inclination can be detected based on the maximum intensity difference of the inspection light, and the relative distance can be detected based on the total inspection light intensity.

When the wavelength of the inspection light is different from the wavelength of the illumination light, the partition wall 12 may be a long wavelength transmission type optical filter that transmits light of a longer wavelength than the inspection light and reflects the inspection light. Here, the wavelength λ2 of the illumination light for measuring the vibration spectrum of the observation target A is set to pass through the partition 12 longer than the wavelength λ1 of the inspection light. The inspection light source 11 of FIG. 10 generates inspection light of wavelength λ1, the light source 21 generates illumination light of wavelength λ2, and the light source switching device 27 inspects the illumination light path 1A when measuring the relative inclination and relative distance of the optical probe 1 The light is guided, and the illumination light is guided to the illumination light path 1A at the time of vibration spectrum measurement.

In the present embodiment, the inspection light is irradiated to the observation target A through the illumination light path 1A provided in the optical probe 1. However, instead of this, as shown in FIG. When the arthroscopic illumination light (endoscope illumination light) is illuminated onto the observation target A from the arthroscope (endoscope) 17 inserted into the joint, the arthroscopic illumination light reflected by the observation target A is examined You may use as light.
The arthroscope 17 irradiates arthroscopic illumination light to the observation target A in the joint, and optically observes the observation target A.

In this embodiment, as shown in FIG. 13A, the relative inclination measurement unit 5 and the relative distance measurement unit 8 are provided on the optical probe 1 and a plurality of inspection light paths 1C different from the illumination light path 1A and the collection light path 1B. May be provided. The inspection light path 1C is a fiber Bragg grating (FBG).
The plurality of FBGs 1C are arranged circumferentially around the condensing optical path 1B. At the tip of the optical probe 1, the tip of the FBG 1 C is embedded in the elastic body 14. As shown in FIG. 13B, the proximal end of the FBG 1C extracted from the proximal end of the optical probe 1 detects the inspection light from the inspection light source 11 generating the inspection light and the inspection light from the observation target A via the optical coupler 15 Is connected to the light detector 16.

When the elastic body 14 is deformed by the contact between the tip surface of the optical probe 1 and the observation target A, distortion occurs in the FBG 1C, and a change occurs in the intensity of the return light of the inspection light guided in the FBG 1C. Information on the relative tilt of the optical probe 1 with respect to the observation target A can be obtained from the intensity profile of the return light of the inspection light from each of the FBGs 1C. In addition, since the intensity of the return light of the inspection light from the FBG 1C is also changed by the contact between the elastic body 14 and the observation target A, information of the relative distance (presence or absence of contact with the observation target A) can also be obtained.

Alternatively, as shown in FIG. 13C, the partition 12 is connected to the tip surface of the optical probe 1 via the elastic body 13, and the return light of the inspection light reflected by the partition 12 and guided in the inspection light path 1C is detected. It is also good. In this case, the relative inclination detection unit 6 detects the relative inclination based on the bias of the intensity of the return light of the inspection light guided through the plurality of inspection optical paths 1C. Therefore, the inspection optical path 1C is not an FBG, but a normal light. It may be a fiber.

Second Embodiment
Next, a vibration spectrum measuring apparatus according to a second embodiment of the present invention will be described with reference to the drawings.
In the present embodiment, a configuration different from the first embodiment will be described, and the configuration common to the first embodiment is assigned the same reference numeral and the description will be omitted.
In the vibration spectrum measuring apparatus 200 according to the present embodiment, the relative inclination measuring unit 51 and the relative distance measuring unit 81 respectively measure the pressure acting on the tip surface of the optical probe 1 as a physical quantity that changes according to the relative inclination and the relative distance. It differs from the first embodiment in that it measures.

The vibration spectrum measurement apparatus 200 includes an optical probe 1, a vibration spectrum measurement unit 2, a vibration spectrum determination unit 3, and a report unit 4 as shown in FIG. 14. In addition, the vibration spectrum measuring apparatus 200 includes a relative inclination measurement unit 51, a relative inclination detection unit 61, a relative inclination determination unit 71, a relative distance measurement unit 81, a relative distance detection unit 91, and a relative distance determination unit 101. Is equipped.

As shown in FIGS. 15A and 15B, the relative inclination measurement unit 51 includes a pressure sensor unit 51a provided on the tip surface of the optical probe 1 and having a plurality of contact pressure sensors 51c, and the pressure is measured by the pressure sensor 51c. measure. The pressure sensor unit 51a is an annular member having an opening 51b through which illumination light and signal light pass at positions corresponding to the illumination light path 1A and the collection light path 1B as shown in FIG. The plurality of pressure sensors 51c are arranged at equal intervals in the circumferential direction of the pressure sensor unit 51a.

The pressure sensor 51c is a capacitive pressure sensor, and generates a voltage according to the magnitude of the pressure acting on the pressure sensor 51c. Specifically, as shown in FIG. 17, the capacitive pressure sensor 51c has a substrate 51d and electrode layers disposed on both sides of the substrate 51d, and the electrode layer is protected by an insulator 51f. It is done. Each electrode layer is composed of a pair of electrodes 51e, and a wire 51g is sandwiched between the electrode layer and the insulator 51f.

A relation of Q = C × V is established between the charge Q on the electrode 51e, the electrostatic capacitance C, and the voltage V between the electrodes 51e. When the distance between the pair of electrodes 51e is narrowed according to the pressure acting on the pressure sensor 51c, the capacitance C is increased, and the voltage V is decreased by an amount according to the amount of change in the distance between the electrodes 51e. .

The relative inclination detection unit 61 is individually connected to each pressure sensor 51 c via the wiring 51 g. The relative inclination detection unit 61 can detect at which position in the pressure sensor unit 51a the voltage of the pressure sensor 51c has changed from the magnitude of the voltage received from each pressure sensor 51c through the wiring 51g. . Here, as shown in FIG. 15A, when the relative inclination is small and the pressure sensor unit 51a is in uniform contact with the surface of the observation target A, the magnitudes of the voltages generated by all the pressure sensors 51c become substantially uniform. . On the other hand, as shown in FIG. 15B, when the relative inclination is large and the pressure sensor unit 51a is inclined and in contact with the surface of the observation object A, the voltage generated by the plurality of pressure sensors 51c is shown in FIG. A bias occurs in the size. When the plurality of pressure sensors 51c are arranged at equal intervals in the circumferential direction, the bias of the magnitude of the voltage is more in accordance with the relative inclination. Therefore, the relative inclination detection unit 61 can detect the magnitude of the relative inclination based on the deviation of the magnitude of the voltage generated by the plurality of pressure sensors 51c.

Specifically, the relative inclination detection unit 61 detects the magnitude of the relative inclination as follows.
The relative inclination detection unit 61 includes a storage device (not shown) and an arithmetic device (not shown), and stores the magnitude of the voltage from each pressure sensor 51c in the storage device. In the storage device, data of charge Q of pressure sensor 51c, dielectric constant ε, electrode area S, initial electrode interval d1, and relative position coordinates (X, Y) of each pressure sensor 51c are stored in advance.

The distance d2 between the pair of electrodes 51e is calculated from the following equation.
d2 = ε × S × V / Q
The arithmetic device reads the voltage of each pressure sensor 51c from the storage device, calculates the current electrode spacing d2 of each pressure sensor 51c, and calculates the difference between the initial electrode spacing d1 and the current electrode spacing d2. The calculated difference represents the relative distance between the tip surface of the optical probe 1 and the observation target A at the position (X, Y) of each pressure sensor 51 c.

The relative inclination detection unit 61, as shown in FIG. 19, sets the relative distance at the position of each pressure sensor 51c as the Z coordinate, and indicates the relative position coordinate (X, Y) of each pressure sensor 51c and the relative distance in a three-dimensional coordinate space Plot to and calculate the least squares plane of multiple plots. The calculated least square plane is a plane which approximates the surface of the observation target A with respect to the tip surface of the optical probe 1. Therefore, an angle θ formed by the normal line of the least square plane and the Z axis is the relative inclination between the tip surface of the optical probe 1 and the observation target A. The relative inclination detection unit 61 detects an angle θ formed by the normal line of the least square plane and the Z axis as a relative inclination.

The relative inclination determination unit 71 includes a storage device (not shown) and an arithmetic device (not shown). In the storage device, the allowable range of the magnitude of the relative inclination is stored in advance. The arithmetic device determines whether the magnitude of the relative inclination detected by the relative inclination detection unit 61 is within the allowable range.
The relative tilt determination unit 71 is electrically connected to the control device 26 and the report unit 4 of the vibration spectrum measurement unit 2, and the determination result by the relative tilt determination unit 71 is the control device 26 and the report of the vibration spectrum measurement unit 2. It is sent to the part 4.

Similar to the relative inclination detection unit 61, the relative distance measurement unit 81 includes a pressure sensor unit 51a.
The relative distance detection unit 91 is individually connected to each pressure sensor 51 c via a wire 51 g. As described above, the magnitude of the voltage generated by the capacitive pressure sensor 51c is determined by the amount of change in the distance between the electrodes 51e. The relative distance detection unit 91 detects the relative distance at the position of each pressure sensor 51c in the pressure sensor unit 51a from the magnitude of the voltage received from each pressure sensor 51c via the wiring 51g.

The relative distance determination unit 101 includes a storage device (not shown) and an arithmetic device (not shown). In the storage device, the allowable range of the relative distance size is stored in advance. The computing device determines whether the relative distance detected by the relative distance detection unit 91 is within the allowable range. The relative distance determination unit 101 is electrically connected to the control device 26 and the report unit 4 of the vibration spectrum measurement unit 2, and the determination result by the relative distance determination unit 101 corresponds to the control device 26 and the report of the vibration spectrum measurement unit 2. It is sent to the part 4.

Thus, according to the present embodiment, the relative inclination and relative distance of the optical probe 1 with respect to the observation target A can be detected based on the magnitudes of pressure acting on a plurality of positions on the tip surface of the optical probe 1 it can.

In this embodiment, a capacitive pressure sensor is used as the contact pressure sensor, but instead, as shown in FIG. 20, a piezoelectric sensor 51h having a piezoelectric element 51i is used. It is also good. The piezoelectric sensors 51 h are arranged at equal intervals in the circumferential direction on the tip surface of the optical probe 1 as in the capacitive pressure sensor 51 c.
The piezoelectric sensor 51 h includes a piezoelectric element 51 i and a pair of electrodes 51 j sandwiching the piezoelectric element 51 i. When the thickness of the piezoelectric element 51i changes due to the pressure acting on the piezoelectric sensor 51h, the piezoelectric element 51i generates a voltage having a magnitude corresponding to the amount of change in thickness due to the piezoelectric effect. The voltage generated by the piezoelectric element 51i is measured via the wire 51g connected to the electrode 51j. Therefore, the relative inclination can be detected based on the bias of the voltage magnitudes of the plurality of piezoelectric sensors 51h, and the relative distance can be detected based on the voltage magnitudes of the plurality of piezoelectric sensors 51h.
In the present modification, the thickness of the piezoelectric element 51i may be controlled to correct the relative inclination and the relative distance by applying a voltage to the piezoelectric element 51i via the wiring 51g.

Third Embodiment
Next, a vibration spectrum measuring apparatus according to a third embodiment of the present invention will be described with reference to the drawings.
In the present embodiment, a configuration different from the first embodiment will be described, and the configuration common to the first embodiment is assigned the same reference numeral and the description will be omitted.
In the vibration spectrum measuring apparatus 300 according to the present embodiment, the relative inclination measuring unit 52 and the relative distance measuring unit 82 respectively use the reflected waves of the ultrasonic waves from the optical probe 1 as physical quantities that change according to relative inclination and relative distance. It differs from the first embodiment in that it measures.

As shown in FIG. 21, the vibration spectrum measurement apparatus 300 includes an optical probe 1, a vibration spectrum measurement unit 2, a vibration spectrum determination unit 3, and a report unit 4. The vibration spectrum measuring apparatus 300 further includes a relative inclination measurement unit 52, a relative inclination detection unit 62, a relative inclination determination unit 72, a relative distance measurement unit 82, a relative distance detection unit 92, and a relative distance determination unit 102. Is equipped.

The relative inclination measuring unit 52 and the relative distance measuring unit 82 each include an ultrasonic examination device 18 mounted on the distal end of the arthroscope (endoscope) 17. The ultrasonic inspection apparatus 18 radiates ultrasonic waves radially as shown in FIG. When an object is present in the irradiation range of the ultrasonic wave, the object generates a reflected wave of the ultrasonic wave. The ultrasonic inspection device 18 receives the reflected wave of the ultrasonic wave, and measures the distance to the object present in the irradiation range of the ultrasonic wave for each unit solid angle based on the received reflected wave. Thereby, distances from the ultrasonic inspection apparatus 18 to each position on the surface of the observation target A and each position on the surface of the optical probe 1 are obtained.

The relative inclination detection unit 62 reproduces the surrounding environment of the ultrasonic inspection apparatus 18 based on the distance for each unit solid angle measured by the relative inclination measurement unit 52.
Specifically, the relative inclination detection unit 62 plots the distance per unit solid angle in the space coordinate system centered on the ultrasonic inspection apparatus 18, and performs processing for complementing the gap between the plots, as shown in FIG. As shown, a three-dimensional estimated peripheral model around the ultrasound system 18 is created. Next, the relative inclination detection unit 62 determines the surface of the optical probe 1 and the surface of the observation target A from the estimated peripheral model based on the relative positional relationship between the arthroscope 17 and the ultrasonic inspection apparatus 18, and the estimated optical probe surface P1, an estimated optical probe tip surface P2, and an estimated observation target surface P3 are set. Next, the relative inclination detection unit 62 calculates the estimated optical probe optical axis Q1 from the estimated optical probe surface P1, calculates the intersection of the estimated optical probe optical axis Q1 and the estimated observation target surface P3, and estimates the observation target at the intersection. The angle θ formed by the normal line Q2 of the plane P3 and the estimated optical probe optical axis Q1 is calculated. The calculated angle is the magnitude of the relative inclination.

The relative inclination determination unit 72 includes a storage device (not shown) and an arithmetic device (not shown). In the storage device, the allowable range of the magnitude of the relative inclination is stored in advance. The arithmetic device determines whether or not the magnitude of the relative inclination detected by the relative inclination detection unit 62 is within the allowable range. The relative tilt determination unit 72 is electrically connected to the control device 26 and the report unit 4 of the vibration spectrum measurement unit 2, and the determination result by the relative tilt determination unit 72 corresponds to the control device 26 and the report of the vibration spectrum measurement unit 2. It is sent to the part 4.

Similar to the relative tilt detection unit 62, the relative distance detection unit 92 creates a three-dimensional estimated peripheral model, sets the estimated optical probe tip surface P2 and the estimated observation target surface P3, and sets the estimated optical probe optical axis Q1. calculate. Next, the relative distance detection unit 92 calculates the distance d from the estimated optical probe tip surface P2 to the intersection of the estimated optical probe optical axis Q1 and the estimated observation target surface P3. The calculated distance d is a relative distance.

The relative distance determination unit 102 includes a storage device (not shown) and an arithmetic device (not shown). In the storage device, an allowable range of relative distance is stored in advance. The arithmetic device determines whether the relative distance detected by the relative distance detection unit 92 is within the allowable range. The relative distance determination unit 102 is electrically connected to the control device 26 and the report unit 4 of the vibration spectrum measurement unit 2, and the determination result by the relative distance determination unit 102 corresponds to the control device 26 and the report of the vibration spectrum measurement unit 2. It is sent to the part 4.

Thus, according to the present embodiment, the distance from the ultrasonic inspection apparatus 18 to the tip of the observation target A and the optical probe 1 based on the reflection wave of the ultrasonic wave from the observation target A and the tip of the optical probe 1 The relative inclination and relative distance of the optical probe 1 with respect to the observation target A can be detected by measuring

In the first to third embodiments described above, as shown in FIG. 24, a vibration spectrum correction unit 19 that corrects the vibration spectrum measured by the vibration spectrum measurement unit 2 may be further provided. The vibration spectrum correction unit 19 is electrically connected to the vibration spectrum measurement unit 2, the relative tilt determination unit 7, and the relative distance determination unit 10.
The apparent intensity of the vibration spectrum of the observation object A measured by the vibration spectrum measurement unit 2 changes depending on the relative inclination and relative distance between the optical probe 1 and the observation object A.

The vibration spectrum correction unit 19 includes a storage device (not shown) and an arithmetic device (not shown). The vibration spectrum correction unit 19 stores the vibration spectrum of the observation object A acquired by the vibration spectrum measurement unit 2 in the storage device, and the relative tilt determination unit 7 and the relative distance determination unit 10 use the relative tilt used for the determination. And information of relative distance is received and stored in a storage device.

The storage device stores correction coefficient data of apparent intensity when the optical probe 1 and the observation target A are disposed at a predetermined relative inclination and a predetermined relative distance. The arithmetic device corrects the apparent intensity change of the vibration spectrum by multiplying the vibration spectrum of the observation object A read out from the storage device by the correction coefficient. The vibration spectrum determination unit 3 determines the success or failure of the measurement based on the vibration spectrum whose apparent intensity has been corrected.
In this way, it is possible to obtain a vibration spectrum in which the change in intensity due to the relative tilt and the difference in relative distance is reduced.

In the first to third embodiments described above, as shown in FIG. 25, based on the determination results by the relative tilt determination unit 7 and the relative distance determination unit 10, the observation target A from the arthroscope (illumination device) 17 is A lighting control unit 20 may be further provided to control the state of the arthroscopic illumination light emitted to the light source.
The illumination control unit 20 is a device having a filter switching function of switching an optical filter built in the illumination unit 171 that supplies the arthroscopic illumination light to the arthroscope 17. The illumination control unit 20 is electrically connected to the relative tilt determination unit 7, the relative distance determination unit 10, and the vibration spectrum measurement unit 2. The illumination control unit 20 receives the information on the determination results of the relative inclination and the relative distance executed by the relative inclination determination unit 7 and the relative distance determination unit 10, and switches the optical filter of the illumination unit 171 to obtain the illumination unit 171 The state, eg, intensity or spectrum, of the arthroscopic illumination light supplied to the arthroscope 17 is changed. Alternatively, the illumination control unit 20 may control an opening / closing device that opens / closes a shutter for illumination light provided in the illumination unit 171.

When the relative inclination determination unit 7 and the relative distance determination unit 10 determine that the relative inclination and the relative distance are appropriate, the relative inclination determination unit 7 and the relative distance determination unit 10 transmit a signal to the illumination control unit 20. The illumination control unit 20 receives the determination result (the relative distance and the relative inclination are appropriate). The illumination control unit 20 also receives information on the exposure time (time T) of the light detector 24 set in the control device 26 of the vibration spectrum measurement unit 2. Prior to the start of measurement of the vibration spectrum by the vibration spectrum measurement unit 2, the illumination control unit 20 sets the state of the arthroscopic illumination light from the arthroscope 17 to a predetermined time t (t from start of measurement of the vibration spectrum to measurement completion). Change only during> T). Thereby, the intensity of the arthroscopic illumination light irradiated from the arthroscope 17 to the observation target A temporarily decreases during the time required for measurement of the vibration spectrum of the observation target A, or the spectrum shape of the arthroscopic illumination light Changes, or the arthroscopic illumination is temporarily blocked. By doing this, the light amount and spectrum shape of the arthroscopic illumination light are changed to reduce the influence of stray light derived from the arthroscopic illumination light superimposed on the vibration spectrum, and the vibration spectrum measuring unit 2 A high vibration spectrum of the observation object A can be obtained.

100, 200, 300 Vibration spectrum measuring apparatus 1 Optical probe 2 Vibration spectrum measuring unit 3 Vibration spectrum judging unit 4

Report units

5, 51, 52 Relative

inclination measuring unit

6, 61, 62 Relative

inclination detecting unit

7, 71, 72 Relative

inclination Determination unit

8, 81, 82 Relative

distance measurement unit

9, 91, 92 Relative

distance detection unit

10, 101, 102 Relative distance determination unit 11 Examination light source 12 Partition wall 13 Elastic body 17 Arthroscope (endoscope)
18 ultrasonic inspection apparatus 19 vibration spectrum correction unit 20 illumination control unit

Claims

It is a long optical probe which emits illumination light from a tip end surface to an observation target and receives signal light generated in the observation target by irradiation of the illumination light at the tip end surface, wherein the illumination light is guided An optical probe having an illumination light path to be guided and a collection light path for guiding the signal light;
A relative tilt measurement unit that measures a physical quantity that changes according to the magnitude of the relative tilt between the observation target and the optical probe;
A relative tilt detection unit that detects the magnitude of the relative tilt based on the physical quantity measured by the relative tilt measurement unit;
A relative inclination determination unit that determines whether or not the magnitude of the relative inclination detected by the relative inclination detection unit is within a predetermined allowable range;
A vibration spectrum measuring device comprising: a vibration spectrum measuring unit for measuring a vibration spectrum of the signal light guided by the condensed light path of the optical probe based on a judgment result by the relative tilt judging unit.
A relative distance measurement unit that measures a physical quantity that changes according to the magnitude of the relative distance between the observation target and the tip surface of the optical probe;
A relative distance detection unit that detects the magnitude of the relative distance based on the physical quantity measured by the relative distance measurement unit;
A relative distance determination unit that determines whether or not the magnitude of the relative distance detected by the relative distance detection unit is within a predetermined allowable range;
The vibration spectrum measuring apparatus according to claim 1, wherein the vibration spectrum measurement unit measures a vibration spectrum of the signal light based on the determination result by the relative tilt determination unit and the determination result by the relative distance determination unit.
A vibration spectrum determination unit that evaluates the vibration spectrum measured by the vibration spectrum measurement unit and determines success or failure of measurement of the vibration spectrum of the observation target;
The vibration spectrum measuring apparatus according to claim 1, further comprising: a report unit that reports the determination result by the vibration spectrum determination unit.
The vibration spectrum measuring apparatus according to claim 1, further comprising: a vibration spectrum correction unit configured to correct the vibration spectrum measured by the vibration spectrum measurement unit based on the magnitude of the relative tilt detected by the relative tilt detection unit.
The vibration spectrum measuring apparatus according to claim 2, further comprising: a vibration spectrum correction unit that corrects the vibration spectrum measured by the vibration spectrum measurement unit based on the magnitude of the relative distance detected by the relative distance detection unit.
The vibration spectrum according to claim 1, further comprising: an illumination control unit configured to control a state of light emitted to the observation target from an illumination device that is separate from the optical probe based on the determination result by the relative tilt determination unit. measuring device.
The vibration spectrum according to claim 2, further comprising: an illumination control unit configured to control a state of light emitted to the observation target from an illumination device that is separate from the optical probe based on the determination result by the relative distance determination unit. measuring device.
The relative tilt measurement unit measures the intensity of the inspection light collected by at least one of the illumination light path and the collection light path disposed on the tip end surface of the optical probe,
The vibration spectrum measuring apparatus according to claim 1, wherein the relative inclination detection unit detects the magnitude of the relative inclination based on the intensity of the inspection light measured by the relative inclination measurement unit.
The relative distance measurement unit measures the intensity of the inspection light collected by at least one of the illumination light path and the collection light path disposed on the tip surface of the optical probe,
The vibration spectrum measuring apparatus according to claim 2, wherein the relative distance detection unit detects the magnitude of the relative distance based on the intensity of the inspection light measured by the relative distance measurement unit.
The relative tilt measurement unit has a plurality of inspection light paths provided in the optical probe and different from the illumination light path and the collection light path, and the light is condensed by the plurality of inspection light paths on the tip surface of the optical probe. Measure the intensity of multiple inspection lights,
The vibration spectrum measuring apparatus according to claim 1, wherein the relative inclination detection unit detects the relative inclination based on a difference between the intensities of the plurality of inspection lights measured by the relative inclination measurement unit.
The relative distance measuring unit is provided in the optical probe and has a plurality of inspection light paths different from the illumination light path and the collection light path, and is condensed by the plurality of inspection light paths on the tip surface of the optical probe Measure the intensity of multiple inspection lights,
The vibration spectrum measuring apparatus according to claim 2, wherein the relative distance detection unit detects the relative distance based on magnitudes of intensities of the plurality of inspection lights measured by the relative distance measurement unit.
Said optical probe comprises a plurality of said collection paths;
The relative tilt measurement unit emits inspection light from the illumination light path of the optical probe toward an object facing the tip surface of the optical probe, and is reflected by the object and collected by the plurality of collected light paths. Measuring the intensity of the plurality of inspection lights,
The vibration spectrum measuring apparatus according to claim 8, wherein the relative inclination detection unit detects the relative inclination based on a difference between the intensities of the plurality of inspection lights measured by the relative inclination measurement unit.
Said optical probe comprises a plurality of said collection paths;
The relative distance measurement unit emits inspection light from the illumination light path of the optical probe toward an object facing the tip surface of the optical probe, and is reflected by the object and collected by the plurality of collected light paths. Measuring the intensity of the plurality of inspection lights,
10. The vibration spectrum measuring apparatus according to claim 9, wherein the relative distance detection unit detects the relative distance based on magnitudes of intensities of the plurality of inspection lights measured by the relative distance measurement unit.
Said optical probe comprises a plurality of said collection paths;
The inspection light is endoscope illumination light irradiated from an endoscope to the observation target,
The relative inclination measurement unit measures the intensities of the plurality of inspection light beams reflected by the observation target and collected by the plurality of collection light paths,
The vibration spectrum measuring apparatus according to claim 8, wherein the relative inclination detection unit detects the relative inclination based on a difference between the intensities of the plurality of inspection lights measured by the relative inclination measurement unit.
Said optical probe comprises a plurality of said collection paths;
The inspection light is endoscope illumination light irradiated from an endoscope to the observation target,
The relative distance measurement unit measures the intensities of the plurality of inspection lights that are reflected by the observation target and collected by the plurality of collected light paths,
10. The vibration spectrum measuring apparatus according to claim 9, wherein the relative distance detection unit detects the relative distance based on magnitudes of intensities of the plurality of inspection lights measured by the relative distance measurement unit.
The vibration spectrum measuring device according to claim 10 or 11, wherein the plurality of inspection light paths are made of a fiber Bragg grating.
The vibration spectrum measurement unit includes a light source that generates the illumination light.
The vibration spectrum measuring apparatus according to claim 12, wherein the inspection light is the illumination light generated by the light source of the vibration spectrum measurement unit.
The vibration spectrum measurement unit includes a light detector that detects the illumination light;
The vibration spectrum measuring apparatus according to claim 14, wherein the relative inclination measurement unit measures the intensity of the inspection light by the light detector of the vibration spectrum measurement unit.
The vibration spectrum measurement unit includes a light detector that detects the illumination light;
The vibration spectrum measuring apparatus according to claim 15, wherein the relative distance measuring unit measures the intensity of the inspection light by the light detector of the vibration spectrum measuring unit.
The vibration spectrum measuring apparatus according to claim 12, wherein the object is the observation target.
The partition according to claim 12 or 13, wherein the object is a partition wall connected to the tip end surface of the optical probe via an elastic body and applied to the observation target and reflecting at least a part of the inspection light. Vibration spectrum measuring device.
The vibration spectrum measuring apparatus according to claim 21, wherein the partition is a long wavelength transmission filter that transmits the illumination light and reflects the inspection light having a wavelength shorter than that of the illumination light.
The light source of the vibration spectrum measurement unit generates excitation light for generating Raman scattered light of the observation target as the illumination light.
The inspection light is the excitation light,
The vibration spectrum measuring apparatus according to claim 17, wherein the light detector of the vibration spectrum measuring unit measures a Raman spectrum of the observation target and detects the inspection light.
The relative tilt measurement unit includes a plurality of contact-type pressure sensors arranged on the tip surface of the optical probe,
The vibration spectrum measuring apparatus according to claim 1, wherein the relative inclination detection unit detects the magnitude of the relative inclination based on a difference between a plurality of pressures respectively measured by the plurality of contact pressure sensors.
The relative distance measurement unit includes a plurality of contact-type pressure sensors arranged on the tip surface of the optical probe,
The vibration spectrum measuring apparatus according to claim 2, wherein the relative distance detection unit detects the relative distance based on magnitudes of a plurality of pressures respectively measured by the plurality of contact pressure sensors.
The vibration spectrum measuring apparatus according to claim 24 or 25, wherein the plurality of contact pressure sensors are arranged circumferentially equally around the illumination light path and the collection light path of the optical probe.
The vibration spectrum measuring device according to any one of claims 24 to 26, wherein the contact pressure sensor is a capacitance pressure sensor or a piezoelectric sensor.
The relative inclination measurement unit and the relative distance measurement unit emit ultrasonic waves and receive reflected waves of the ultrasonic waves from the observation object and the optical probe, and based on the received reflected waves, the observation object and the reflected wave. It has an ultrasonic inspection device that measures the distance to each position of the optical probe,
The relative inclination detection unit and the relative distance detection unit detect the relative inclination and the relative distance based on the distances to the respective positions of the observation target and the optical probe measured by the ultrasonic inspection apparatus. The vibration spectrum measuring device according to Item 2.
The vibration spectrum measuring device according to claim 28, wherein the ultrasonic inspection device is attached to an endoscope for observing the observation target.