WO2019025504A1 - Procédé et dispositif pour l'exécution d'un procédé cyclique faisant intervenir au moins un agent antimicrobien - Google Patents

Procédé et dispositif pour l'exécution d'un procédé cyclique faisant intervenir au moins un agent antimicrobien Download PDF

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Publication number
WO2019025504A1
WO2019025504A1 PCT/EP2018/070899 EP2018070899W WO2019025504A1 WO 2019025504 A1 WO2019025504 A1 WO 2019025504A1 EP 2018070899 W EP2018070899 W EP 2018070899W WO 2019025504 A1 WO2019025504 A1 WO 2019025504A1
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WIPO (PCT)
Prior art keywords
solution
antimicrobial
solvent
antimicrobial agent
mist
Prior art date
Application number
PCT/EP2018/070899
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German (de)
English (en)
Inventor
Mathias BATRAM
Original Assignee
Arridus International Ag
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Publication of WO2019025504A1 publication Critical patent/WO2019025504A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/14—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means with multiple outlet openings; with strainers in or outside the outlet opening
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/22—Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B12/00—Arrangements for controlling delivery; Arrangements for controlling the spray area
    • B05B12/16—Arrangements for controlling delivery; Arrangements for controlling the spray area for controlling the spray area
    • B05B12/18—Arrangements for controlling delivery; Arrangements for controlling the spray area for controlling the spray area using fluids, e.g. gas streams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/15—Biocide distribution means, e.g. nozzles, pumps, manifolds, fans, baffles, sprayers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B1/00—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means
    • B05B1/34—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl
    • B05B1/3402—Nozzles, spray heads or other outlets, with or without auxiliary devices such as valves, heating means designed to influence the nature of flow of the liquid or other fluent material, e.g. to produce swirl to avoid or to reduce turbulencies, e.g. comprising fluid flow straightening means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B14/00—Arrangements for collecting, re-using or eliminating excess spraying material
    • B05B14/40—Arrangements for collecting, re-using or eliminating excess spraying material for use in spray booths
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B16/00—Spray booths
    • B05B16/40—Construction elements specially adapted therefor, e.g. floors, walls or ceilings
    • B05B16/405—Partly or totally cylindrical walls; Round floors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00—Processes for applying liquids or other fluent materials
    • B05D1/02—Processes for applying liquids or other fluent materials performed by spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • B05D3/04—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases
    • B05D3/0406—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases the gas being air
    • B05D3/042—Directing or stopping the fluid to be coated with air

Definitions

  • the present invention is an apparatus for applying an antimicrobial coating on a surface, a method for performing a cyclic process with at least one antimicrobial agent, a method for
  • the invention in particular relates to a disinfection of articles and in particular a hand disinfection.
  • Transmission chains must be interrupted by efficient hand disinfection.
  • hand disinfection In order to enable frequent use with the least possible side effects on humans and the environment, hand disinfection must also be skin-friendly and environmentally friendly. Therefore, on the one hand water as solvent or
  • Suspending agent or dispersing agent for the antimicrobial agent is preferable to alcohol, and on the other hand is a recovery of the antimicrobial
  • Active substance desirable, as far as it does not adhere to the surfaces to be disinfected and remains. At the same time, it is necessary to avoid the spread of spray mist in the ambient air with which parts of disinfecting substances and / or components of non-eliminated pathogens are spread and inhaled in a harmful way could become. Furthermore, a simple and quick application is essential so that existing disinfection devices are actually used. Finally, the application should also be non-contact, so that not just by touching the disinfecting device, such as a surface, a button or a handle operating a contamination of the hands with germs of other users.
  • Hand disinfection known. From the patent application DE 10 2010 020 887 AI a device for disinfecting hands in a chamber with a front opening is known, are placed by the hands from the front, and spray nozzles within the chamber through which a disinfectant is sprayed on the hands, wherein two separate chambers are provided, with a chamber for the right hand and a chamber for the left hand. However, a leakage of spray from the chambers is not prevented. According to a particularly advantageous embodiment, a collecting container for excess disinfectant liquid is arranged below the chambers, a recovery of the disinfecting agents is not provided.
  • the invention is therefore based on the object to provide a device and a method by means of which the disadvantages of the prior art, in particular the disinfection of objects and hand disinfection are overcome.
  • This object is achieved by the device according to the invention for applying an antimicrobial coating to a surface according to claim 1, by the method according to the invention for carrying out a cyclic process with at least one antimicrobial agent having the features according to claim 12, by the method for producing an antimicrobial coating on a surface according to claim 21, and by the process for the recovery of at least one antimicrobial active ingredient according to claim 27.
  • antimicrobial agent is used below to refer to an agent that has biocidal and / or biostatic properties to microbes.
  • Merobes include single-celled or low-cell microscopic organisms such as, in particular Bacteria, fungi, protozoa, microalgae and viruses found in humans and / or animals
  • antimicrobial agent is used, wherein a
  • antimicrobial agent or a mixture of several antimicrobial agents or a mixture of one or more antimicrobial agents with one or more suitable excipients and / or additives.
  • the antimicrobial agent is preferably dissolved in a suitable solvent, but may also be present as a dispersion, suspension or emulsion.
  • An antimicrobial coating according to the present invention is a more or less adherent layer of informal antimicrobial agent on one
  • This surface may be the surface of an object, but also the human or animal skin.
  • the individual particles of the antimicrobial active ingredient can enter into a more or less firm bond with each other and / or with the surface, so they can also form, for example, a polymerized layer.
  • the layer may be thick, but it may also be an approximately monomolecular layer.
  • Laminar flows behave just so that in a direction perpendicular to the flow direction propagating
  • Re Reynolds number
  • A is the cross-sectional area traversed and U is the wetted perimeter.
  • the deciding factor is the Reynolds number of a flow and the (empirically determined) critical Reynolds number.
  • the critical Reynolds number depends on the configuration of the
  • Flow and the flow-through hollow body determine and indicates the upper limit for which there is a laminar flow.
  • turbulent flows are straight streams that have a Reynolds number that is greater than the critical one
  • the critical Reynolds number is about 2300.
  • the critical Reynolds number depends on the flow resistance and may differ greatly from the above-mentioned value of the simple pipe flow.
  • the (mean) flow velocity hereinafter refers to the velocity, averaged over the flow cross-section, of the directed movement of a fluid or a combination of different fluids.
  • the device according to the invention for applying an antimicrobial coating to a surface consists of a hollow body with one or more openings through which objects to be coated with an antimicrobial coating can be introduced into the hollow body, a nebulizing device for nebulizing at least one antimicrobial active agent dissolved in a solvent for generating a high-velocity flow of the atomized at least one antimicrobial active ingredient dissolved in a solvent and means for transporting the atomised at least one antimicrobial active ingredient dissolved in a solvent to the hollow body, the flow flowing through a multiplicity of nozzle-like outlets into the hollow body for producing a antimicrobial coating on the at least one in the
  • the laminar flow is substantially orthogonal to the
  • the device has a recovery device for
  • One advantage is that the at least one antimicrobial agent dissolved in the solvent is at least partially reused. This improves the environmental friendliness and cost efficiency of the device according to the invention.
  • the device has a filter device for filtering the at least one dissolved in a solvent antimicrobial agent.
  • the device has a blocking air device for limiting the flow to the interior of the hollow body.
  • a blocking air device for limiting the flow to the interior of the hollow body.
  • the inner lateral surfaces of the hollow body are substantially defined by two differently shaped opposite ellipsoidal surfaces, wherein the hollow body has openings on the end faces.
  • Objects such as two hands held parallel to each other and in a relaxed posture with their fingertips facing each other in front of the human body, is particularly suitable. Such ergonomics are beneficial for regular use.
  • the ellipsoidal surfaces of the hollow body are formed in such a way that a first ellipsoidal surface defines a convex part of the hollow body and a second ellipsoidal surface defines a concave part of the hollow body.
  • Hollow body allowed without touching the walls.
  • the hollow body distributed over the perimeters of its openings one or more column arrangements of air purge nozzles and air purifier or
  • Blocking air nozzles a particularly efficient flow barrier can be constructed, which reliably prevents unwanted leakage of the atomized wetting agent with the flow from the hollow body.
  • the wetting is carried out with a solution of an antimicrobial active ingredient and is particularly advantageously used for hand disinfection.
  • the apparatus further comprises one or more storage containers for the at least one antimicrobial active agent dissolved in a solvent, wherein the one or more storage containers are provided with a contact-bound or
  • contactless identification system in particular equipped with RFID technology. This ensures that only certain or suitable for the present use or approved solutions of antimicrobial agents are used and / or that a reservoir is used only once. This restriction serves in particular the safety and hygiene of the device.
  • a first method according to the invention for carrying out a cyclic process with at least one antimicrobial active ingredient uses a solvent in which one or more antimicrobial active substances are dissolved.
  • the solution of antimicrobial agent (s) is either in a mist phase or in a liquid phase.
  • the method according to the invention has at least the following steps:
  • Solution of the liquid phase in the mist phase preferably below
  • a ventilation system such as one or more fans
  • a part of the solvent exits by evaporation from the cycle.
  • Solvent is released and unfolds its desired effect at the location of evaporation of the solvent.
  • the solvent used is water, a short- or medium-chain alcohol, a phenol, a glycol, glycerol, ethylhexylglycerol, diglycerol, an ester of a short- or medium-chain alcohol or a phenol, an ether of a short- or medium-chain Alcohol or a phenol, a carboxylic acid, a primary or secondary amine, a primary or secondary amide, propylene glycol, polyethylene glycol, acetone or a mixture of two or more of these solvents used.
  • Short- or medium-chain alcohols can have both purely aliphatic and aliphatic-aromatic side chains.
  • the alcohols used are methanol, ethanol, n-propanol, isopropanol, isobutanol, hexanol and benzyl alcohol.
  • Phenols include simple and substituted phenols, as well as their salts.
  • Examples of ethers used are phenoxyethanol and 1-phenoxy-2-propanol.
  • the solvent is a mixture of water and at least one short- or medium-chain alcohol.
  • the alcohol is present in a concentration of about 65 to about 80% by weight.
  • This solvent has the advantage that a large number of antimicrobial agents are soluble therein. Furthermore, in this embodiment, the solvent already has antimicrobial activity.
  • the solvent is essentially water. This is particularly advantageous because it is environmentally friendly and does not affect most surfaces, especially when human or animal skin is wetted by the solution containing the antimicrobial agent. Another advantage is the skin compatibility of this solvent, for example compared to alcohol.
  • One advantage is that one or more arbitrarily shaped three-dimensional objects are applied substantially uniformly with the antimicrobial agent.
  • the one or more three-dimensional objects are interchangeable in the given space.
  • the solution of the antimicrobial agent in the mist phase is partially enclosed by wall surfaces and partly by a barrier flow.
  • the antimicrobial agent in mist form does not escape from the predetermined but not completely closed space.
  • the barrier flow prevents the mist from being inhaled or from being deposited on objects outside the given space.
  • the predetermined space is formed so that the one or more objects can be inserted into the predetermined space without its
  • Impurities of the wall surfaces caused by the objects in particular that no microbes are transmitted from the objects to the wall surfaces and from these to other objects and that the cycle especially by contactless sensors can be activated. This eliminates the need to operate a mechanical switch, strap or lever, etc., whereby a transmission of microbes is excluded in this way.
  • the first method according to the invention can be applied in preferred embodiments for the production of an antimicrobial coating on a surface.
  • Place wetting chamber Place wetting chamber.
  • the computer mouse If it is desired to equip a computer mouse or keyboard with the antimicrobial agent so as to provide an antimicrobial coating on the surfaces intended to be touched by the hands, the computer mouse is placed in the wetting chamber and removed from the solution of antimicrobial agent in the form of mist flows substantially laminar. After a predetermined time of misting the computer mouse, which may be between 5 seconds and 2 minutes, preferably between 7 and 15 seconds, the computer mouse can be removed from the wetting chamber again. After drying, ie evaporation of the solvent is the computer mouse with the
  • the particle size of the atomized solution and / or the proportion of the liquid in the air of the mist phase is so low that the precipitated mist phase has only a low moisture content and thus the computer mouse or other coated objects are not damaged or impaired.
  • Coating on a surface involves the following steps:
  • One advantage is that the mist spreads faster in the given space and hits the surface at a higher speed.
  • the accelerated mist is directed to form a substantially laminar flow through guide channels. Because of a substantially laminar flow of high speed, the advantage is achieved that the mist hits the surface at high speed and thus very well on the surface adheres. In a substantially laminar flow, the fog layers do not mix. In a turbulent flow, however, turbulences and cross flows occur, which lead to an uneven distribution of the solution of the antimicrobial agent on the surface. According to the invention, it is advantageous if the average flow speed of the mist from the nozzles is always below 10 m / s in some embodiments that are stationary. It is particularly advantageous if the mean flow velocity is about 5 m / s and the maximum flow velocity is about 6.5 m / s.
  • the amount of air moved is about 46 m 3 / h. With a uniform distribution of the amount of air over the total area of the outlet nozzles results in an average speed of about 4.6 m / s. Will continue to a high
  • flow velocity refers to an average flow velocity of at least 2 m / s at the
  • Embodiments of the device a higher flow rate is used. This higher flow rate can be up to 20 m / s and in special embodiments up to 30 m / s.
  • the mist is passed in a further step through a plurality of openings before the mist impinges on the surface.
  • the mist is distributed substantially evenly in the given space and impinges on the surface.
  • the mist in a further step in one or more wetting chambers on the surface.
  • one or more surfaces are wetted in one or more wetting chambers.
  • the method is applied to the surface of a human hand.
  • An advantage is that the surface of the hand wets through the mist the drying is protected by the antimicrobial coating so that microbes do not come into direct contact with the skin and may possibly penetrate into the body through cracks.
  • a further method according to the invention consists in reconstituting a solution of at least one antimicrobial agent, which is passed through the cyclic process and is not deposited on a surface, back into the cyclic process
  • the solution is passed in a sixth step through a filter device to filter out impurities from the solution which have been introduced into the solution in steps one to five.
  • a filter device to filter out impurities from the solution which have been introduced into the solution in steps one to five.
  • the at least one antimicrobial agent is a disinfectant.
  • the at least one antimicrobial active ingredient is selected from the group comprising quaternary ammonium compounds, phenolic compounds, monohydric short-chain alcohols, aldehydes, mild organic acids, hydrogen peroxide, hypochlorous acid and plant extracts.
  • Ouartaric ammonium compounds have the Advantage that they have a good solubility in water and a good antimicrobial activity and in addition, especially in quaternary ammonium compounds having at least one long alkyl group, have a surface-active effect. Thus, they positively affect the water solubility of any other antimicrobial agents present.
  • univalent short-chain alcohols for example, methanol, ethanol, n-propanol, isopropanol, isobutanol, hexanol, phenoxyethanol, l-phenoxy-2-propanol can be selected.
  • a preferred aldehyde is, for example, glutaraldehyde.
  • Mild organic acids are, for example, citric acid, lactic acid, glycolic acid or fruit acids such as
  • Tartaric acid malic acid, shikimic acid or acetic acid.
  • herbal extracts for example, extracts of rosemary, turmeric, neem tree and cilantro can be used.
  • the antimicrobial agent is N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N-(2-aminoethyl)-2-aminoethyl-N
  • Benzalkonium chloride sold under the name Hyamine ® 3500 from Lonza Inc. USP, benzethonium chloride, sold under the name Hyamine ® 1622 by Lonza Inc., or a mixture of both.
  • Preferred phenolic antimicrobial agents are 5-chloro-2- (2,4-dichlorophenoxy) -phenol (triclosan) and / or 4-chloro-3,5-dimethylphenol (PCMX; para-chloro-meta-xylenol).
  • the antimicrobial agent is benzalkonium chloride and / or
  • Benzethonium chloride A preferred monohydric short chain alcohol is ethanol.
  • benzalkonium chloride having a chain length of C12 to C16 (CAS 68424-85-1) can be used.
  • benzalkonium chlorides containing CAS 63449-41-2 C 8 -C 8 alkyl
  • CAS 68391-01-5 C 2 -C 8 alkyl
  • CAS 8001-54-5 unspecified alkyl
  • the solution of the at least one antimicrobial active ingredient additionally contains a suitable humectant and / or a suitable spreading agent.
  • Suitable humectants and / or spreading agents are, for example, ingredients which are used on the basis of the European Cosmetics Regulation in cosmetic products can find.
  • Suitable humectants and / or spreading agents are, for example, sorbitol, glycerol, polysaccharides, cyclomethicone, cyclopentasiloxane, glycol, ethylene glycol, polyethylene glycol-6, lactic acid, sodium lactate, polyglycerol esters, isopropyl myristate or water-soluble silicones.
  • a water-soluble silicone for example polydimethylsiloxane (Dimethicone, CAS 63148-62-9) available as Dow Corning ® 190 surfactant.
  • the solution of the at least one antimicrobial active ingredient advantageously additionally contains a silane having functional groups selected from -OR, -NR 2 , -R-NR 2 ,
  • An advantage of the antimicrobial agent having three hydroxy or alkoxy groups is relatively good water solubility, which further depends on the nature of the other functional group. also
  • Another advantage is that the polymerization takes place with dehydration, so that no skin-damaging reaction products.
  • an antimicrobial agent containing a trisilanol or a
  • Trimethoxysilane is associated with another functional group, which is a quaternary
  • Ammonium salt having a C10 - C19 alkyl group or a C3 - C6 cycloalkyl group.
  • an antimicrobial agent according to the following formula is used: OR
  • R ' Ci or Cs-Cio alkyl
  • n, m 2, 3, 4, ..., 18 and 10 ⁇ n + m ⁇ 25.
  • dimethyloctadecyl- [3- (trimethoxysilyl) propyl] ammonium chloride (CAS 27668- 52-6), dimethyltetradecyl- [3- (trimethoxysilyl) propyl] -ammonium chloride (CAS 41591-87-1), methyldidecyl- [3- (trimethoxysilyl ) propyl] -ammonium chloride (CAS 68959-20-6) and / or dimethyloctadecyl- [3- (trihydroxysilyl) propyl] -ammonium chloride (CAS 199111-50-7) as silanes.
  • a particularly advantageous silane is dimethyloctadecyl- [3- (trimethoxysilyl) propyl] -ammonium chloride.
  • the silanes mentioned can polymerize, in particular on evaporation or other removal of the solvent, both among one another and with individual functional groups of the wetted surface.
  • the polymerization is preferably one
  • silsesquioxanes having 6, 8, 10 or 12 silane units would be preferred oligomers.
  • Conceivable polymers are, for example, polysilanes, polysiloxanes and particularly preferably polysilsesquioxanes. This coating exerts antimicrobial action, as does the active ingredient itself. This effect also persists because the active ingredient is not consumed on contact with microbes.
  • a further advantage of the antimicrobial coating in the case of human skin is the formation of a coating which, by virtue of its activity inhibiting microbial growth, also prevents the microbes inherently present in deeper skin layers from reaching the skin surface intact from the deeper layers. Thus, by the coating can be prevented that microbes are transmitted,
  • a suitable solvent is water as far as the antimicrobial agent is soluble therein in sufficient concentration. In the case of poor solubility in water, it is also possible to use further of the abovementioned solvents in low concentrations up to one
  • Concentration of water to further solvent of 10: 1 and / or a suitable solubilizer may be added in lower or the same concentration.
  • Fig. 1 is a truncated front perspective view of the device.
  • Fig. 2 is a truncated rear perspective view of the device.
  • Fig. 3 is a side vertical section of the device and the half “ball”.
  • Fig. 4 is a schematic front view with stylized hands and movement in the "gap”.
  • Fig. 5 is a schematic oblique view with stylized hands and movement in the "gap”.
  • Fig. 6 shows a vertical section with stylized hands and movement in the "gap”.
  • Fig. 7 is a central vertical section of the device and the half "ball”.
  • Fig. 8 is a plan view from above of the device.
  • Fig. 9 is an oblique view of the device.
  • FIG. 10 shows a detailed view of a nebulizing nozzle.
  • Fig. 11 is a vertical section of a return system.
  • Fig. 12 is a detail view of a basin for the creation of a mist.
  • Fig. 13 is a schematic detail view of a blocking air system with locking air slots.
  • Fig. 14 is a detail view of a blocking air generation with sealing air ducts.
  • Fig. 15 is a detail view of a blocking air generation with sealing air ducts (components).
  • Fig. 16 is a schematic representation of the generated mist and the air streams.
  • FIG. 1 shows a perspective view of a preferred embodiment of the device 100 according to the invention.
  • the hollow body 200 has two ellipsoidal surfaces 210 and 220, wherein the hollow body 200 in the region of the front, away from the user wall 210 has a convex bulge, while in the region of the rear, the user nearby wall 220 has a concave bulge.
  • the hands of the user held in front of the body can be introduced into the anatomically shaped hollow body 200 in parallel and with mutually directed fingertips in a natural position, without touching the wall surfaces 201.
  • FIG. 2 shows a further perspective view of a preferred embodiment of the device 100 according to the invention.
  • This device has a fogging device 300 for atomizing a wetting agent comprising, for example, a ventilator 310 which supplies the atomized wetting agent through an arrangement of openings 320, which are preferably designed as nozzles and are arranged in the wall surfaces 201, preferably at high speed and particularly preferably with the formation of a laminar flow on surfaces introduced into the hollow body 200, in particular on introduced palms.
  • the formation of the ellipsoidal surfaces 210, 220 and a matrix arrangement of the openings or nozzles 320 causes the introduced surfaces or palms to be wetted uniformly from all sides and also in concave areas and spaces with the wetting agent. Furthermore visible are blocking air arrangements 350 with blocking air nozzles 360 and
  • FIG. 3 shows a further schematic sketch of the device 100 and the "half ball" 220.
  • the inner ellipsoid surface 220 is ergonomically designed such that it can be encompassed like a half ball when the hands are inserted into the disinfection device 100, but without the wall surfaces 201 Both wall surfaces 201 are with
  • Nebulization nozzles 320 occupied, through which the solution exits and preferably flows in the form of a laminar flow at high speed into the hollow body 200.
  • Barrier air fans 370 create a flow of blocking air through the
  • Barrier air channels 380 is directed to the blocking air nozzles 360, not shown in Figure 3, to prevent leakage of the atomized wetting agent from the hollow body 200.
  • Figure 4 shows another schematic sketch of the device 100, wherein stylized
  • Blocking air nozzles 360 prevent leakage of the spray from the hollow body 200 at the end faces 110, 120th
  • FIG. 5 shows a further schematic sketch of the device 100 in an oblique view, wherein the viewing direction 400 of a user is indicated in perspective.
  • Stylized forearms or hands 401, 402 of the user are through the openings 101, 102 on the end faces 110, 120 introduced into the hollow body 200.
  • a nebulizer fan 310 and a sealing air fan 370 and a sealing air channel 380 are also shown.
  • FIG. 6 shows a further schematic sketch of the device 100 in a side view, wherein the viewing direction 400 of a user is indicated. Shown is the inserted into the hollow body 200 right hand 402 of the user.
  • Ellipsoidal surface (of the "half ball") 220 and the outer ellipsoidal surface 210 causes the hand can be introduced into the hollow body in a natural attitude, without touching the wall surfaces 201.
  • the user's palms 401, 402 through the nebulization nozzles 320 is substantially uniformly wetted from all sides with a substantially laminar flow of the atomized solution, whereby it is advantageous if the user spreads his fingers
  • a non-polymerizing portion of the antimicrobial agent on the user's palms 401, 402 is collected together with a non-evaporating portion of the solvent in return channels 330, separated from contaminants and microbes by a filtering device 335 and returned to the nebulizer 300.
  • the filter device 335 has a component in the form of a sieve, which is inserted at the lowest point of the hollow body 200 and in a preferred
  • Embodiment is easily replaceable.
  • the fogging device 300 is arranged. This consists of a pot-like basin for generating mist 345 and a Vernebier 305.
  • the Vernebier 305 is of conventional design and produces a mist, if it is surrounded by a certain amount of the solvent.
  • a mixing chamber 348 is arranged, in which the merged air streams are substantially rectified, i. the air streams have a substantially laminar character when taken from the
  • Fogger 300 enriched with fog ascend to be subsequently guided to the inner and outer ellipsoidal surfaces 220, 210.
  • FIG. 7 shows a schematic representation of the device 100 in side view with a hollow body 200, an inner ellipsoid surface 220 and an outer ellipsoid surface 210, wherein the viewing direction 400 of a user is indicated.
  • the ellipsoidal surfaces have a matrix-like arrangement of nebulization nozzles 320.
  • the filter device 335 has a component in the form of a screen, which is inserted at the lowest point of the hollow body 200 and in a preferred embodiment easily replaceable. Further visible is the mixing chamber 348 above the fogging device 300.
  • FIG. 8 shows a schematic representation of the device 100 in plan view with a hollow body 200, an inner ellipsoid surface 220 and an outer ellipsoid surface 210.
  • the ellisoid surfaces have a matrix-like arrangement of nebulization nozzles 320.
  • Blocking air fans 370 produce a blocking air flow, which is conducted by means of the sealing air channels 380 to the blocking air nozzles 360 and there prevents the escape of the atomized solution from the openings 101, 102 of the hollow body 200.
  • the laminar flow of the atomized solution is limited by the barrier air flow to the volume of the hollow body 200.
  • FIG. 9 shows a schematic representation of the hull 200 of the device 100 in an oblique view.
  • the hollow body 200 is formed by an inner ellipsoidal surface 220 and an outer ellipsoidal surface 210.
  • the ellipsoidal surfaces have a matrix-like arrangement of nebulization nozzles 320.
  • FIG. 10 shows a schematic sectional detail view of a nebulizing nozzle 320, which is arranged in a wall surface 201.
  • a solution is by means of
  • Nebulizing nozzle 320 nebulizes and forms a plurality of individual mist droplets 203, which flow with an air flow 202 in the hollow body 200 and there surfaces located, such. Moisten palms substantially evenly.
  • Mist droplets 203 according to FIG. 10 are only shown schematically. The size of the mist droplets 203 can not be taken to scale from FIG.
  • the illustrated ellipses labeled 203 represent the location at which the mist droplets are carried in a laminar flow 202 after exiting the nebulizing nozzle 320.
  • Figure 11 shows a schematic detail view of a misting fan 310 and the return channels 330.
  • the solution is reused by the return channels 330 returned to nebulizer 300 (any tubing or tubing is not shown) and reused.
  • FIG. 12 shows a schematic detail view of an apparatus 340 for creating a mist, which has a pot-like basin 345 for the generation of mist, in which a mist is created and is not visible in the hollow body 200 via air flows caused by guide channels 341 (not visible in FIG ).
  • the guide channels 341 are inventively designed so that a laminar flow along the guides 341 is formed.
  • the curves and inlet areas are designed so that the
  • Curvature radii support formation of a laminar flow.
  • Ellipsoid Assembly 210 are substantially equal. This advantage is achieved by matching the cross-sectional areas of the guides 341 for the inner ellipsoidal surface 220 and the outer ellipsoidal surface 210.
  • the solution consisting of a solvent and at least one antimicrobial agent is, as far as the solvent is not evaporated and the antimicrobial agent is not polymerized on the surfaces, collected in return channels 330 (not visible in FIG. 12) through a filter device 335 (in FIG not visible) from contaminants and microbes and to nebulizer 300
  • FIG. 13 shows a schematic detail view of the barrier air arrangement 350, which
  • Blocking air fans 370, sealing air channels 380 and blocking air nozzles 360 has.
  • the hollow body 200 has at the end faces 110, 120 sealing air arrangements 350 with blocking air nozzles 360 which generate a blocking air flow at the open end faces 110, 120 of the hollow body 200.
  • FIG. 14 shows a schematic detail view of a blocking air generation 355, in which sealing air fans 370 and sealing air ducts 380 are shown in the assembled state.
  • FIG. 15 shows a schematic component representation of a blocking air fan 370 and a half-shell of the blocking air channel 380.
  • FIG. 16 shows a schematic illustration of the device 340 for creating a mist with the mist generation basin 345.
  • essential air streams 342 and flow directions 343 are schematically represented, which flow inlet 346 into the guide channels 341 to a flow outlet 347 from the device 340 to create a mist above the vaporizer 305.
  • the mist produced in the vat 305 is conveyed upwardly into the inner and outer ellipsoidal surfaces (not shown in Figure 16) by the schematically shown air streams 342.
  • the air streams 342 are passed through the guide channels 341 so that the air flows in
  • Embodiments of the device (AI to A4). This was for different
  • Outlet geometries determined the Reynolds number at the outlet and in the vicinity of the hand simulatively.
  • the critical Reynolds number (Re crit ) of the flow introduced into the wetting chamber is approximately 8500 to 10000. In the exemplary embodiments shown, the Reynolds number is approx. 2000 or less below the critical one
  • the outlet flow has a substantially laminar character. It is particularly advantageous for a homogeneous and efficient application of the hand surface when the Reynolds number in the vicinity of the hand is significantly smaller than the critical Reynolds number of about 300,000 to 1,000,000 (at typical hand widths). From the table it can be seen that for all embodiments, the Reynolds number is well below the interval of the critical values. Thus, the hand is acted upon in the embodiments shown with a substantially laminar flow.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

L'invention concerne un dispositif pour l'application d'un revêtement antimicrobien sur une surface, un procédé pour l'exécution d'un procédé cyclique faisant intervenir au moins un agent antimicrobien, un procédé pour la production d'un revêtement antimicrobien sur une surface, ainsi qu'un procédé pour la récupération de l'agent antimicrobien ou des agents antimicrobiens, l'invention concernant en particulier la désinfection d'objets et en particulier la désinfection de mains.
PCT/EP2018/070899 2017-08-01 2018-08-01 Procédé et dispositif pour l'exécution d'un procédé cyclique faisant intervenir au moins un agent antimicrobien WO2019025504A1 (fr)

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DE102017007264.7 2017-08-01
DE102017007264.7A DE102017007264A1 (de) 2017-08-01 2017-08-01 Verfahren und Vorrichtung zur Durchführung eines Kreisprozesses mit mindestens einem antimikrobiellen Wirkstoff

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210137120A1 (en) * 2019-11-11 2021-05-13 Parasol Medical, Llc Sanitizing and antimicrobial solution with silane quaternary ammonium with hypochlorous acid
GB2596398A (en) * 2020-05-07 2021-12-29 Dougan Kieran Hand Sanitising apparatus
FR3116202A1 (fr) * 2020-11-18 2022-05-20 Evercleanhand Appareil de désinfection avec dispositif de collecte

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5193563A (en) * 1990-04-30 1993-03-16 Melech Victor P Surgical suite scrub station
JP2004011315A (ja) * 2002-06-07 2004-01-15 Amemiya Kiki Kk 手の洗浄・乾燥・消毒セット
WO2008054907A2 (fr) * 2006-10-31 2008-05-08 Icon Systems, Llc Chambre de lavage pour appareil de lavage d'appendice automatisé
DE102010020887A1 (de) 2010-05-18 2011-11-24 Anton Henssen Handdesinfektionsgerät

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5193563A (en) * 1990-04-30 1993-03-16 Melech Victor P Surgical suite scrub station
JP2004011315A (ja) * 2002-06-07 2004-01-15 Amemiya Kiki Kk 手の洗浄・乾燥・消毒セット
WO2008054907A2 (fr) * 2006-10-31 2008-05-08 Icon Systems, Llc Chambre de lavage pour appareil de lavage d'appendice automatisé
DE102010020887A1 (de) 2010-05-18 2011-11-24 Anton Henssen Handdesinfektionsgerät

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210137120A1 (en) * 2019-11-11 2021-05-13 Parasol Medical, Llc Sanitizing and antimicrobial solution with silane quaternary ammonium with hypochlorous acid
GB2596398A (en) * 2020-05-07 2021-12-29 Dougan Kieran Hand Sanitising apparatus
FR3116202A1 (fr) * 2020-11-18 2022-05-20 Evercleanhand Appareil de désinfection avec dispositif de collecte
EP4000654A1 (fr) * 2020-11-18 2022-05-25 Evercleanhand Appareil de desinfection avec dispositif de collecte fluidique

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DE202018006330U1 (de) 2020-01-30

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