WO2019021320A3 - A neural conduit to reconstitute and regenerate the degenerated or damaged nervous system - Google Patents

A neural conduit to reconstitute and regenerate the degenerated or damaged nervous system Download PDF

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Publication number
WO2019021320A3
WO2019021320A3 PCT/IN2018/050496 IN2018050496W WO2019021320A3 WO 2019021320 A3 WO2019021320 A3 WO 2019021320A3 IN 2018050496 W IN2018050496 W IN 2018050496W WO 2019021320 A3 WO2019021320 A3 WO 2019021320A3
Authority
WO
WIPO (PCT)
Prior art keywords
degenerated
reconstitute
regenerate
neural conduit
nervous system
Prior art date
Application number
PCT/IN2018/050496
Other languages
French (fr)
Other versions
WO2019021320A2 (en
Inventor
Sandeep Kumar Vishwakarma
Aleem Ahmed Khan
Avinash Bardia
Syed Ameer Basha Paspala
Md. Aejaz Habeeb
Original Assignee
Dr Habeebullah Life Sciences Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Habeebullah Life Sciences Limited filed Critical Dr Habeebullah Life Sciences Limited
Publication of WO2019021320A2 publication Critical patent/WO2019021320A2/en
Publication of WO2019021320A3 publication Critical patent/WO2019021320A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3675—Nerve tissue, e.g. brain, spinal cord, nerves, dura mater
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3878—Nerve tissue, brain, spinal cord, nerves, dura mater
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Abstract

A neural conduit to reconstitute and regenerate the degenerated or damaged nervous system comprising of acellularized meningeal scaffold repopulated with functional neuronal cells. The said neural conduit can be used as a biological implant in neurological conditions for filling the tissue gaps and in spinal cord injuries. A method for producing the neural conduit, comprising of repopulating the acellularized meningeal scaffold with regenerative cells to produce a large number of functional neuronal cells to augment the damaged/dysfunctional neural circuits
PCT/IN2018/050496 2017-07-27 2018-07-27 A neural conduit to reconstitute and regenerate the degenerated or damaged nervous system WO2019021320A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201741026728 2017-07-27
IN201741026728 2017-07-27

Publications (2)

Publication Number Publication Date
WO2019021320A2 WO2019021320A2 (en) 2019-01-31
WO2019021320A3 true WO2019021320A3 (en) 2019-09-12

Family

ID=65040039

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2018/050496 WO2019021320A2 (en) 2017-07-27 2018-07-27 A neural conduit to reconstitute and regenerate the degenerated or damaged nervous system

Country Status (1)

Country Link
WO (1) WO2019021320A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140356331A1 (en) * 2011-07-08 2014-12-04 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Injectable cns-derived ecm for tissue reconstruction
US20160030635A1 (en) * 2013-03-15 2016-02-04 Anthrogenesis Corporation Improved method of making extracellular matrix compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140356331A1 (en) * 2011-07-08 2014-12-04 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Injectable cns-derived ecm for tissue reconstruction
US20160030635A1 (en) * 2013-03-15 2016-02-04 Anthrogenesis Corporation Improved method of making extracellular matrix compositions

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ASSUNCAO-SILVA ET AL.: "Hydrogels and Cell Based Therapies in Spinal Cord Injury Regeneration", STEM CELLS INTERNATIONAL, vol. 2015, 2015, pages 948040, XP055637474 *
CRAPO ET AL.: "Biologic scaffolds composed of central nervous system extracellular matrix", BIOMATERIALS, vol. 33, no. 13, 2012, pages 3539 - 3547, XP028461957, DOI: 10.1016/j.biomaterials.2012.01.044 *
DEQUACH ET AL.: "Decellularized Porcine Brain Matrix for Cell Culture and Tissue Engineering Scaffolds", TISSUE ENG PART A, vol. 17, no. 21-22, 2011, pages 2583 - 92, XP055489119, DOI: 10.1089/ten.tea.2010.0724 *
GATTAZZO ET AL.: "Extracellular matrix: A dynamic microenvironment for stem cell niche", BIOCHIMICA ET BIOPHYSICA ACTA (BBA), vol. 1840, no. 8, 2014, pages 2506 - 19, XP028872916, DOI: 10.1016/j.bbagen.2014.01.010 *
PUTNAM: "The Instructive Role of the Vasculature in Stem Cell Niches", BIOMATERIAL SCIENCE, vol. 2, no. 11, 2014, pages 1562 - 1573, XP055637501 *
SHRESTHA ET AL.: "Repair of injured spinal cord using biomaterial scaffolds and stem cells", STEM CELL RESEARCH & THERAPY, vol. 5, no. 4, 2014, pages 91, XP021208906, DOI: 10.1186/scrt480 *
VISHWAKARMA ET AL.: "Bioengineering Human Neurological Constructs Using Decellularized Meningeal Scaffolds for Application in Spinal Cord Injury", FRONT BIOENG BIOTECHNOL, vol. 6, 1 November 2018 (2018-11-01), pages 150, XP055637503 *

Also Published As

Publication number Publication date
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