WO2019015092A1 - 一种用于治疗脑动脉硬化的中药 - Google Patents

一种用于治疗脑动脉硬化的中药 Download PDF

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WO2019015092A1
WO2019015092A1 PCT/CN2017/103369 CN2017103369W WO2019015092A1 WO 2019015092 A1 WO2019015092 A1 WO 2019015092A1 CN 2017103369 W CN2017103369 W CN 2017103369W WO 2019015092 A1 WO2019015092 A1 WO 2019015092A1
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chinese medicine
cerebral arteriosclerosis
traditional chinese
treating cerebral
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PCT/CN2017/103369
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English (en)
French (fr)
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王淑英
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淄博齐鼎立专利信息咨询有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8988—Gastrodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638—Ligustrum, e.g. Chinese privet
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Definitions

  • the invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating cerebral arteriosclerosis.
  • Cerebral arteriosclerosis is a part of systemic arteriosclerosis, and it is also the main pathogenesis of acute cerebral blood circulation, especially ischemic attack. It is a general term for degeneration and hardening of cerebral arterial wall caused by various factors.
  • Cerebral arteriosclerosis is characterized by dizziness, headache, forgetfulness, mood changes, or limb numbness. It belongs to the category of “dizziness”, “headache” and “dementia” in Chinese medicine. Chinese medicine believes that the disease involves liver, heart and spleen. The kidneys are dirty, and they are especially close to the liver and heart. Through the cloud, “the winds are dizzy, all belong to the liver", “the head is the meeting of Zhuyang, the wind is easy to reach”, the liver is the dirty of the wind wood, the internal phase of the fire body is yin and the yang is active.
  • the main blood of the heart is also the main god, the modern life work is tense, the emotional loss is caused by the liver stagnation, the refining liquid is sputum, the phlegm is blocked, and the veins are dying.
  • the etiology and pathogenesis of the disease is mainly due to the physical weakness of the elderly, lack of vitality, and the inability to replenish the limbs, turbidity, blood stasis.
  • the disease is mainly in the blood, the virtual master is in the kidney, liver, spleen, the main force is turbid, blood stasis, and there is qi stagnation.
  • Hawthorn meat [alias] ⁇ jujube, rat, chicken feet, hawthorn meat, real jujube, meat jujube, jujube, clam meat, jujube.
  • This product is a dry mature flesh of Hawthorn plant Hawthorn. When the peel turns red at the end of autumn and winter, the fruit is harvested. After baking with a simmer or boiling water, the core is removed and dried. [Sexual taste] acid, sputum, lukewarm. [Return] to the liver, kidney. [Indications] Replenishing liver and kidney, phlegm and fine.
  • Atractylodes [alias] in surgery, winter surgery, Zhejiang surgery, seed surgery. [Source] This product is the dried rhizome of Atractylodes macrocephala. In the winter, when the lower leaves are yellow and the upper leaves become brittle, they are excavated, removed from the sediment, dried or dried, and then the roots are removed. [Sexual taste] bitter, sweet, warm. [Return to the spleen] stomach, stomach. [Indications] spleen and qi, dampness and water, antiperspirant, and fetus. For spleen deficiency, less bloating, diarrhea, sputum, edema, edema, spontaneous sweating, fetal movement.
  • Huang Wei cotton, cotton, yellow.
  • This product is the dried root of the leguminous plant Astragalus membranaceus or Astragalus membranaceus. Excavate in the spring and autumn, remove the roots and roots, and dry. [Sexual taste] sweet, warm. [Return] to the lungs, spleen. [Indications] qi and solid table, diuretic toxic, drainage, sore muscles.
  • the invention aims to provide a traditional Chinese medicine for treating cerebral arteriosclerosis, and achieve the purpose of safe and effective treatment of cerebral arteriosclerosis by selecting appropriate medicinal materials and their ratios.
  • a traditional Chinese medicine for treating cerebral arteriosclerosis which is prepared by the following raw materials of weight ratio: 12 parts of gastrodia, 12 parts of Shichangpu, 10 parts of hawthorn meat, 10 parts of Atractylodes, and Chuanxiong 15 15 parts of Cassia, 12 copies of Ligustrum lucidum, 20 parts of Astragalus.
  • cerebral arteriosclerosis According to the diagnostic criteria of the national clinical meeting of cerebral arteriosclerosis: (1) neurasthenia syndrome such as headache, dizziness, fatigue, lack of concentration, memory loss, emotional instability, slow thinking, sleep disorders (insomnia or lethargy), etc. The condition fluctuated. (2) Carotid atherosclerotic plaque micro-embolic detachment can occur transient ischemic attack, coronary atherosclerosis causes angina pectoris, lower extremity atherosclerosis intermittent claudication, cerebral arteriosclerosis can be based on chronic brain insufficiency A transient cerebral ischemic syndrome occurs. Angina is considered a clinical symptom of coronary arteriosclerosis, and TCIA (except cardiac) is considered a clinical symptom of cerebral arteriosclerosis.
  • the arteriosclerosis of the fundus can be seen as thinning of the arteries, and the reflection is enhanced. In severe cases, the filaments and the arteries and veins are cross-pressed. Palmar reflex, sputum reflex positive, patients with history of stroke can leave brain damage, hemiplegia, partial body
  • Positioning signs such as sensory disturbances.
  • the treatment group was orally administered the capsule prepared according to the specific example 3 of the present invention 3 times a day.
  • the course of treatment is 2 months.
  • the control group received oral Gynostemma total bracts, 2 tablets/time, 3 times/day.
  • the course of treatment is 2 months.
  • the medicine prepared by the invention can safely and effectively treat cerebral arteriosclerosis and has the promotion value.

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Abstract

一种用于治疗脑动脉硬化的中药，它是由下列重量份的原料药制成的：天麻12、石菖蒲12、山萸肉10、白术10、川芎15、决明子15、女贞子12、和黄芪20。

Description

一种用于治疗脑动脉硬化的中药 技术领域
本发明涉及一种中药，具体涉及一种用于治疗脑动脉硬化的中药。
背景技术
脑动脉硬化是全身动脉硬化的一部分，同时也是急性脑血循环尤其是脑缺血发作的主要发病基础，是各种因素导致的脑动脉管壁变性和硬化的总称。
脑动脉硬化症以眩晕、头痛、健忘、情绪改变，或有肢体麻木等为主要临床表现，属中医“眩晕”、“头痛”、“痴呆”范畴，中医学认为本病涉及肝、心、脾、肾四脏，且与肝、心两脏功能尤为密切。经云“诸风掉眩，皆属于肝”、“头为诸阳之会，唯风可及”，肝为风木之脏，内寄相火体阴用阳，其性主升主动。心主血脉又主神明，现代生活工作紧张，情志失遂致肝郁化火，炼液为痰，痰瘀阻络，脉络失养而成。其病因病机主要为年老体虚，精气不足，精微不能充养四肢百脉，痰浊、瘀血阻脉。病位主在血脉，虚主在肾、肝、脾，实主力痰浊、瘀血，兼有气滞。
本发明所涉及药材研究现状如下：
天麻【别名】赤箭、木浦、明天麻、定风草根、白龙皮。【来源】本品为兰科植物天麻的干燥块茎。春季4～5月间采挖为“春麻”；立冬前9～10月间采挖的为“冬麻”，质量较好。挖起后趁鲜洗去泥土，用清水或白矾水略泡，刮去外皮，水煮或蒸透心，切片，摊开晾干。【性味】甘，平。【归经】归肝经。【功能主治】平肝息风止痉。用于头痛眩晕，肢体麻木，小儿惊风，癫痫抽搐，破伤风。【用法用量】内服：煎汤，3～9g。【注意】使御风草根，勿使天麻，二件若同用，即令人有肠结之患。【摘录】《中华本草》。
石菖蒲【别名】昌本，菖蒲、昌阳，昌羊，尧时薤、尧韭，木蜡、阳春雪、望见消，九节菖蒲，水剑草，苦菖蒲，粉菖，剑草，剑叶菖蒲，山菖蒲、溪菖，石蜈蚣，野韭菜、水蜈蚣、香草。【来源】本品为天南星科植物石菖蒲的干燥根茎。秋、冬二季采挖，除去须根及泥沙，晒干。【性味】辛、苦，温。【归经】归心、胃经。【功能主治】化湿开胃，开窍豁痰，醒神益智。用于脘痞不饥，噤口下痢，神昏癫痫，健忘耳聋。【用法用量】内服：煎汤，3～9g。【注意】阴虚阳亢、烦躁汗多、咳嗽、吐血、精滑者慎服。【摘录】《中华本草》。
山萸肉【别名】蜀枣，鼠矢、鸡足，山萸肉，实枣儿，肉枣，枣皮，萸肉，药枣。【来源】本品为山茱萸科植物山茱萸的干燥成熟果肉。秋末冬初果皮变红时采收果实，用文火烘或置沸水中略烫后，及时除去果核，干燥。【性味】酸、涩，微温。【归经】归肝、肾经。【功能主治】补益肝肾，涩精固脱。用于眩晕耳鸣，腰膝酸痛，阳痿遗精，遗尿尿频，崩漏带下，大汗虚脱。内热消渴。【用法用量】内服：煎汤，6～12g。【注意】凡命门火炽，强阳不痿，素有湿热，小便淋涩者忌服。【摘录】《中华本草》。
白术【别名】于术、冬术、浙术、种术。【来源】本品为菊科植物白术的干燥根茎。冬季下部叶枯黄、上部叶变脆时采挖，除去泥沙，烘干或晒干，再除去须根。【性味】苦、甘，温。【归经】归脾、胃经。【功能主治】健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。土白术健脾，和胃，安胎。用于脾虚食少，泄泻便溏，胎动不安。【用法用量】内服：煎汤，6～12g。【注意】阴虚燥渴，气滞胀闷者忌服。【摘录】《中华本草》。
川芎【别名】芎藭、小叶川芎。【来源】本品为伞形科植物川芎的干燥根茎。夏季当茎上的节盘显着突出，并略带紫色时采挖，除去泥沙，晒后炕干，再去须根。【性味】辛，温。【归经】归肝、胆、心包经。【功能主治】活血行气，祛风止痛。用于月经不调，经闭痛经，症瘕腹痛，胸胁刺痛，跌扑肿痛，头痛，风湿痹痛。【用法用量】内服：煎汤，9～25g。【注意】阴虚火旺，上盛下虚及气弱之人忌服。【摘录】《中华本草》。
决明子【别名】鲍鱼壳、九孔螺、九孔石决明。【来源】本品为鲍科动物杂色鲍(光底海决)、皱纹盘鲍(毛底海决)、羊鲍(大海决)、耳鲍或白鲍的贝壳。夏、秋二季捕捉，去肉，洗净，干燥。【性味】咸，寒。【归经】归肝经。【功能主治】平肝潜阳，清肝明目。用于头痛眩晕，目赤翳障，视物昏花，青盲雀目。【用法用量】内服：煎汤，3～15g。【摘录】《中华本草》。
女贞子【别名】爆格蚤、冬青子。【来源】本品为木犀科植物女贞的干燥成熟果实。冬季果实成熟时采收，除去枝叶，稍蒸或置沸水中略烫后，干燥；或直接干燥。【性味】甘、苦，凉。【归经】归肝、肾、经。【功能主治】滋补肝肾，明目乌发。用于眩晕耳鸣，腰膝酸软，须发早白，目暗不明。【用法用量】 内服：煎汤，6-12g。【注意】脾胃虚寒泄泻及阳虚者忌服。【摘录】《中华本草》。
黄芪【别名】绵芪、绵黄芪。【来源】本品为豆科植物蒙古黄芪或膜荚黄芪的干燥根。春、秋二季采挖，除去须根及根头，晒干。【性味】甘，温。【归经】归肺、脾经。【功能主治】补气固表，利尿托毒，排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴；慢性肾炎蛋白尿，糖尿病。【用法用量】内服：煎汤，9～30g。【摘录】《中华本草》。
发明内容
本发明旨在提供一种用于治疗脑动脉硬化的中药，通过选择合适的药材及其配比，达到安全有效治愈脑动脉硬化的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗脑动脉硬化的中药，其特征在于，它是由以下重量配比的原料药材制备而成：天麻12份、石菖蒲12份、山萸肉10份、白术10份、川芎15份、决明子15份、女贞子12份、黄芪20份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年10月～2013年10月间共收集门诊及住院脑动脉硬化患者100例，随机分为治疗组50例与对照组50例，治疗组男28例，女22例，年龄40～70岁；对照组男24例，女26例，年龄40～70岁，。2组性别、年龄及病程比较差异无统计学意义，具有可比性。
诊断标准
依据全国脑动脉硬化临床专业会议的诊断标准：(1)神经衰弱综合征如头痛、头晕、疲乏、注意力不集中、记忆力减退、情绪不稳、思维迟缓、睡眠障碍(失眠或嗜睡)等，病情起伏波动。(2)颈动脉粥样硬化斑块微栓子脱落偶可发生短暂性脑缺血发作，冠状动脉硬化引起心绞痛、下肢动脉粥样硬化出现间歇性跛行，脑动脉硬化可在慢性脑功能不全基础上发生一过性脑缺血综合征。心绞痛视为冠状动脉硬化的临床症状，将TCIA(心源性除外)视为脑动脉硬化症的临床症状。(3)眼底动脉硬化可见动脉变细，反光增强，严重者呈银丝状及动静脉交叉压迹。掌颏反射、吸吮反射阳性，有脑卒中史患者可遗留脑神经损害、偏瘫、偏身
感觉障碍等定位体征。
2、试验方法
2.1治疗方法
治疗组口服本发明按照具体实施例3制得的胶囊剂，每日3次。疗程2个月。
对照组口服绞股蓝总甙片，2片/次，3次/天。疗程2个月。
3、疗效标准与治疗结果
3.1疗效标准
临床控制：临床症状全部消失，主要检查指标结果正常；
显效：大部分症状消失，主要检查指标结果基本正常；
有效：各种症状有好转，主要检查指标结果有改善；
无效：各种症状及检查指标结果均无改善。
3.2治疗结果见表1。
表1两组疗效比较
Figure PCTCN2017103369-appb-000001
可见，本发明制得的药物能够安全有效治疗脑动脉硬化，具有推广价值。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：天麻12克、石菖蒲12克、山萸肉10克、白术10克、川芎15克、决明子15克、女贞子12克、黄芪20克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗脑动脉硬化。口服，每日分早午晚三次服用。
实施例2
称取：天麻12克、石菖蒲12克、山萸肉10克、白术10克、川芎15克、决明 子15克、女贞子12克、黄芪20克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗脑动脉硬化。口服，每日分早午晚三次服用。
实施例3
称取：天麻12克、石菖蒲12克、山萸肉10克、白术10克、川芎15克、决明子15克、女贞子12克、黄芪20克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗脑动脉硬化。口服，每日分早午晚三次服用。

Claims (4)

  1. 一种用于治疗脑动脉硬化的中药，其特征在于，它是由以下重量配比的原料药材制备而成：天麻12份、石菖蒲12份、山萸肉10份、白术10份、川芎15份、决明子15份、女贞子12份、黄芪20份。
  2. 如权利要求1所述的用于治疗脑动脉硬化的中药，其特征在于，其制备方法为：称取：天麻12份、石菖蒲12份、山萸肉10份、白术10份、川芎15份、决明子15份、女贞子12份、黄芪20份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
  3. 如权利要求1所述的用于治疗脑动脉硬化的中药，其特征在于，其制备方法为：称取：天麻12份、石菖蒲12份、山萸肉10份、白术10份、川芎15份、决明子15份、女贞子12份、黄芪20份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
  4. 如权利要求1所述的用于治疗脑动脉硬化的中药，其特征在于，其制备方法为：称取：天麻12份、石菖蒲12份、山萸肉10份、白术10份、川芎15份、决明子15份、女贞子12份、黄芪20份；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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CN104225426A (zh) * 2014-10-09 2014-12-24 马俊安 一种治疗脑动脉硬化症的中药及其制备方法
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CN104225426A (zh) * 2014-10-09 2014-12-24 马俊安 一种治疗脑动脉硬化症的中药及其制备方法
CN104800601A (zh) * 2015-04-17 2015-07-29 淄博夸克医药技术有限公司 一种用于治疗脑动脉硬化的中药

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