WO2019013199A1

WO2019013199A1 - Annular device blister container

Info

Publication number: WO2019013199A1
Application number: PCT/JP2018/026014
Authority: WO
Inventors: 辰雄真船; 暁中村
Original assignee: 株式会社シード
Priority date: 2017-07-11
Filing date: 2018-07-10
Publication date: 2019-01-17
Also published as: JP6637640B2; JPWO2019013199A1; TW201907883A; TWI737922B

Abstract

The purpose of the present invention is to provide an annular device blister container that exhibits excellent positional stability and shape retention during transfer of an annular device having an opening part at the center. The above purpose is achieved by means of an annular device blister container provided with: (a) a concave accommodation part that accommodates a storage solution and an annular device immersed in the storage solution; (b) a rectangular flange part formed around the accommodation part; (c) an inclined support part extending from one short-side end of the flange part and inclined downward on the bottom side of the accommodation part; (d) an angular support part provided around the other short-side end of the flange part and extending downward on the bottom side of the accommodation part; (e) a lid part covering the accommodation part; and (f) a convex retention part that is provided at the bottom of the accommodation part, contacts the annular device, and has a height such that a topmost part thereof passes through an opening part of the annular device and is disposed close to the lid part.

Description

Blister container for annular devices

Cross-reference to related applications

This application claims the priority of Japanese Patent Application No. 2017-135403 filed on July 11, 2017, the entire disclosure of which is incorporated herein by reference.

The present invention relates to a blister container for annular devices having an opening at the center.

An annular device having an opening at its center is known as a device for efficiently delivering a drug to diseases of the posterior eye tissue such as retina, choroid, sclera, vitreous body and the like (see below patent document) 1 (the entire disclosure of which is incorporated herein by reference). Since the annular device contains a drug, when it is worn on the sclera surface, the delivery of the drug to the posterior eye tissue can be effectively achieved, the effect of which is that of a normal contact lens. Larger than wearing the device containing the drug.

On the other hand, as a blister container in consideration of the storage stability of a normal contact lens and the removal property at the time of use, an inclined bottom is provided in the lens housing portion of the container body sealed with a lid sheet. There is disclosed a blister container formed with a projection for covering a contact lens (see Patent Document 2 below, the entire description of the document is incorporated herein by reference).

International Publication No. 2010/092735 JP, 2016-221059, A

However, since the annular device described in Patent Document 1 has an opening at the central portion, its shape retention is lower than that of a contact lens, so it may be reversed or caused by external factors such as vibration or impact generated at the time of transfer. Twisting is likely to occur. If storage is continued in a state in which inversion or twisting has occurred, it is conceivable that use can not be performed due to a shape defect. There is also the risk of breakage during correction to a normal shape.

When using a blister container that is generally used for transferring contact lenses when transferring such annular devices, the volume of the storage portion for the annular devices is large, so that it is easy for the shape to be abnormal due to vibration or impact during storage. .

In the blister container for contact lenses of Patent Document 2, the gap between the protrusion and the lid is large, and it is considered that the annular device may pass through the gap when the annular device is accommodated, and the annular device is accommodated. In the case of using the same, and there is a problem in positional stability and shape retention.

Then, an object of this invention is to provide the blister container for annular devices which is excellent in position stability and shape retention property at the time of transfer of the annular device which has an opening in the center.

In examining means and methods for solving the above-mentioned problems, the present inventors, in addition to the configuration of the gap between the holding portion and the lid portion formed on the bottom of the annular device housing portion, contain the annular device. I came to focus on the volume of the department. Then, it was considered that, with the configuration of the annular device holding portion, it is possible to achieve both the minimization of the gap between the holding portion and the lid portion and the minimization of the volume of the housing portion.

Based on the above idea, the present inventors further study intensively, and by making the configuration of the annular device holder close to the lid, it is possible to narrow the movable space of the annular device in the housing, and as a result We attempted to develop a blister container for annular devices, assuming that the movement of the annular devices in the container was suppressed and that the occurrence of inversion and twisting of the annular devices during transfer was significantly reduced. As a result, we succeeded in creating a blister container for an annular device having a height at which the annular device holder provided at the bottom of the accommodating portion for accommodating the annular device is in contact with the inner surface of the annular device and close to the lid. . The present invention is an invention completed based on these findings and successful examples.

That is, according to one aspect of the present invention,
(A) a storage solution and a storage unit for storing an annular device to be immersed in the storage solution;
(B) a rectangular flange formed around the housing;
(C) an inclined support portion extended and provided so as to be inclined downward from the one short side end portion of the flange portion to the bottom side of the housing portion;
(D) an angular support portion extending downward on the bottom side of the housing portion around the other short side end portion of the flange portion;
(E) a lid that covers the housing;
(F) A convex holding portion provided at the bottom of the housing portion, in contact with the annular device, and having a height at which the top passes through the opening of the annular device and approaches the lid.
A blister container for an annular device is provided, comprising:

Preferably, the height of the holding portion is formed at a rate of 90 to 100% with respect to the depth of the housing portion.

Preferably, the volume of the holding portion is formed at a ratio of 50 to 80% with respect to the volume of the housing portion.

According to the blister container for an annular device of one aspect of the present invention, the movability of the accommodated annular device in the accommodation portion of the accommodated annular device is suppressed, so that the occurrence of inversion and twisting can be reduced. The annular device transferred using the container is less likely to cause shape abnormality such as inversion or twisting, so that shape defects caused by continuing the shape abnormality can be suppressed. Furthermore, since the correction from the abnormal shape to the normal shape is also unnecessary, it is possible to reduce the damage that is likely to occur at the time of the correction.

BRIEF DESCRIPTION OF THE DRAWINGS Sectional drawing and the top view which show the blister container for annular devices of 1st aspect of this invention. BRIEF DESCRIPTION OF THE DRAWINGS The cross-sectional enlarged view which shows the blister container for annular devices of 1st aspect of this invention. BRIEF DESCRIPTION OF THE DRAWINGS The perspective view of the blister container for annular devices of the 1st aspect of this invention. Sectional drawing and the top view which show the blister container for annular devices of the 2nd aspect of this invention. The perspective view of the blister container for annular devices of the 2nd aspect of this invention.

Hereinafter, although the detail of the blister container for annular devices of this invention is demonstrated, the technical scope of this invention is not limited only by the matter of this item, and this invention is various as long as the objective is achieved. It can take an aspect.

The blister container for an annular device according to one aspect of the present invention comprises the following (a) to (f)
(A) A storage section for storing a storage solution and an annular device to be immersed in the storage solution (b) A rectangular flange section formed around the storage section (c) From one short side end of the flange section Angular support provided extending downward on the bottom side of the accommodation section around the other short side end of the inclined support section (d) flange section extended and provided so as to incline downward on the bottom side of the accommodation section (E) a cover that covers the housing (f) is provided at the bottom of the housing, is in contact with the annular device, and has a height such that the top passes through the opening of the annular device and approaches the lid By providing at least the shape-like holding portion, it is useful as a blister container which significantly reduces the occurrence of inversion and twisting of the accommodated annular device at the time of transfer.

The blister container for an annular device is a blister container for accommodating the annular device, and the accommodating portion, a flange portion connected to the accommodating portion, an inclined support portion and an angular support portion connected to the flange portion, a lid portion covering the accommodating portion By providing at least the holding portion provided in the housing portion, the annular device can be stably held without being reversed or twisted.

The storage portion has a bottom portion and an opening opening upward, and is formed to have a predetermined volume capable of storing the annular device and the storage solution thereof.

The flange portion is formed to extend from the opening of the housing portion to the outer periphery, and has a rectangular shape. The flange portion includes one and the other short side ends and one and the other long side ends. A bottom portion of the housing portion is provided from the vicinity of one short side end of the flange portion to the vicinity of the central portion.

The inclined support portion is provided to extend at the one short side end of the flange portion in the same direction as the bottom side direction of the accommodation portion, that is, in a downward direction.

The angular support portion is provided around the other short side end portion of the flange portion in the same direction as the bottom side of the accommodation portion, that is, in the form of an angular shape extending downward.

The lid portion is sealed by welding the lid portion and the container body at a flange portion extending around the outside of the housing portion.

The holding portion is a mounting portion of the annular device, which protrudes upward to the opening side from the bottom of the housing portion, is close to the extent that it contacts the lid portion, and has a convex shape having a height that may contact the lid portion Provided to have a shape of The protruding top of the holding portion is formed to be able to pass through the opening of the annular device when housing the annular device, and has a shape following the shape of the surface of the annular device, preferably the inner surface of the annular device Formed as. In the present specification, "the inner surface of the annular device" refers to the surface of the annular device in contact with the sclera surface side of the eye.

Hereinafter, in order to clarify the present invention more specifically, an embodiment of the present invention will be described in detail with reference to FIGS. 1 to 5. In the following description, the up and down direction refers to the up and down direction in FIG. 1 which is the up and down direction when the lid of the container is opened.

[Shape of blister container for annular device]
The blister container for an annular device comprises, as a base, a rectangular flange portion 2 and a housing portion 1 having a holding portion 6 thereon, a container main body including an inclined support portion 3 and an angular support portion 4, a lid 5 and the like. The cover 5 is welded to the container body at the flange 2 to seal the contents of the container (FIGS. 1 and 4).

In the blister container for an annular device, the housing portion 1 is a concave shape provided downward from the vicinity of one short side end of the flange portion 2 and is formed with a predetermined volume A for housing the annular device and the storage solution thereof (Figure 2). Furthermore, by providing the holding portion 6 having a shape projecting upward at the bottom of the housing portion 1, the annular device can penetrate through the holding portion 6, be inscribed therein, and be stably held. Here, the bottom portion of the housing portion can be formed into the holding portion 6 by raising the deepest portion 7 thereof.

The shape of the holding portion 6 is not particularly limited as long as the shape is continuously raised upward from the deepest portion 7 of the housing portion 1 and is, for example, hemispherical shape, cubic shape, rectangular solid shape, cylindrical shape, pyramid shape, truncated cone A shape, a truncated pyramid shape, etc. can be taken, and the shape which combined these can be taken (FIG. 2, FIG. 4). At this time, at the time of storage or removal of the annular device placed in the holding portion 6, the surface of the holding portion 6 is chamfered by chamfering in order to prevent generation of a flaw on the inscribed surface of the annular device. It is preferable to form so as not to have it. The width of the retaining portion 6 is such that the top 8 of the retaining portion has a width such that it passes through the opening of the annular device such that the opening of the annular device and the surface of the retaining portion 6 abut The locking action on the annular device is set to a size that can limit the free displacement of the housing 1 in the housing volume A.

Here, the annular device housed in the housing portion 1 of the blister container may be, for example, a circular shape with an open center, and may have a size that does not hinder wearing and can cover the sclera surface, in particular It is not limited. The outer diameter of the annular device is preferably about 16 to 20 mm, and more preferably 18 to 20 mm, from the viewpoint of insertion on the eye, wearability and coverage of the sclera surface. On the other hand, the inner diameter (the width of the opening) of the annular device is preferably about 10 to 15 mm in order to prevent the inner edge of the annular device from contacting the cornea. The direction in which the annular device is accommodated relative to the accommodation unit 1 is not limited. Preferably, the annular device is preferably immersed in the storage solution with the inner surface facing the sclera surface facing downward. By housing the inner surface of the annular device downward with respect to the housing, contamination can be prevented since the user does not need to touch the inner surface when pinching the annular device with a finger. Further, the storage solution is not particularly limited as long as it can store the annular device. For example, water, physiological saline, isotonic buffer etc. are mentioned, It is also possible to use the liquid which melt | dissolved the chemical | medical agent in these.

The height of the holding portion 6 is formed until the topmost portion 8 of the holding portion contacts or touches the lid 5. By minimizing the gap Z between the holding portion 6 and the lid portion 5, the annular device floating in the housing portion 1 passes over the top 8 of the holding portion 6 through the opening of the annular device and the holding portion 6. It becomes possible to prevent moving out (Fig. 1, Fig. 2, Fig. 4). For example, when a normal contact lens is accommodated in the blister container of one embodiment of the present invention, the blister container of one embodiment of the present invention is between the holding portion and the lid in comparison with the blister container for the normal contact lens. Since there is little or no gap, the contact lens is sandwiched between the holder and the lid, which may cause damage to the lens or an adverse effect on the optical characteristics. Thus, the blister container of one aspect of the present invention has a configuration specialized for the storage of annular devices. That is, as shown in FIGS. 2 and 4, the height X of the holding portion is preferably 90 to 100%, more preferably 95 to 100%, with respect to the depth Y of the housing portion.

Further, the volume B of the holding portion 6 is a volume of a region formed in a convex shape from the deepest portion 7 of the housing portion 1 to the topmost portion 8 of the holding portion (FIG. 2). By designing the volume B of the holding portion 6 in the housing portion 1 to be a predetermined ratio, the volume A of the housing portion 1 is limited, so the range of movement of the annular device in the housing portion 1 is also limited. As a result, movement of the annular device out of the holder 6 is suppressed. That is, it is preferable to form the ratio of the volume B of the holding portion 6 to 50 to 80% of the volume A of the holding portion 1, and more preferably 60 to 75. %.

The inclined support 3 is formed to extend downward from the one short side end of the flange 2 in the same direction as the bottom side of the housing 1. The width of the inclined support 3 is preferably in contact with the short side end of the flange 2 at the same or smaller width. In addition, an uneven slip stopper may be attached to at least one surface in the vertical direction of the inclined support portion 3 to have a shape that is easy for the user to hold.

The angular support portion 4 is disposed opposite to the inclined support portion 3 with the accommodation portion 1 interposed therebetween, and extends downward around the other short side end of the flange portion 2 toward the bottom of the accommodation portion 1 It is formed in a horn shape. The angular support portion 4 can be formed extending in the downward direction of the housing portion 1 from the other short side end of the flange portion 2 to the whole or a part of the long side end.

As shown in FIG. 2, the height m of the inclined support 3 is set relative to the height n of the square support 4 in consideration of the stability when the blister container for an annular device is placed on the table. It is preferably 100 to 150%, and more preferably 100 to 120%. When the height m of the inclined support 3 exceeds 150% with respect to the height n of the square support 4, there is a possibility that the storage liquid in the storage unit 1 may spill out when placed on a table after opening. There is concern that Also, when the height m of the inclined support 3 is less than 100% of the height n of the square support 4, the storage liquid may spill out in the same manner, and when it is placed, the center of gravity The container can not be supported because it is biased to the side of the square support.

In the blister container for an annular device, the lid 5 is a sheet type formed of an integral sheet structure from which the entire lid 5 can be removed at the time of opening, or a pull top structure in which only the opening of the storage 1 is removable. It is preferable to form by the pull top type formed by this. In the container shown in FIGS. 1 to 5, the lid 5 is a sheet type. As in the case of the conventional blister container, it is sealed by welding the lid 5 and the container body at the flange 2 extending around the outside of the container 1.

[Material of blister container for annular device]
The lid 5 is preferably formed of the same synthetic resin as the laminate of the polypropylene and the aluminum foil or the container body. The laminate of polypropylene and aluminum foil is preferably press-molded, and the same synthetic resin as the container body is preferably injection-molded. It is preferable to use a general plastic welding method such as thermal welding, ultrasonic welding, high frequency welding, etc. as a bonding method between the lid 5 and the container body, and depending on the material, even using an adhesive or solvent bonding method Good.

The synthetic resin used for the blister container main body for an annular device constituted by the housing portion 1, the flange portion 2, the inclined support portion 3, the angular support portion 4 and the holding portion 6 is sterilized after the annular device and its storage solution are enclosed. In view of carrying out the process, one having heat resistance and chemical resistance that can endure autoclave sterilization is preferable. Generally, polyethylene, polypropylene, alicyclic polyolefin, polyethylene terephthalate, polybutylene terephthalate, polycarbonate, thermoplastic elastomer and the like can be mentioned.

It is preferable from the point of a molding process to use the same synthetic resin in a container main body and the cover part 5, for example, for the blister container for cyclic devices. Furthermore, the blister container for annular devices may also have the advantage of facilitating disposal after use by using a heat-resistant biodegradable resin.

One specific embodiment of the blister container for an annular device is that the depth Y of the container 1 is 2 to 10 mm, preferably 3 to 9 mm; the height m of the inclined support 3 is 3 to 12 mm, preferably 4 to 10 mm Height n of the square support 4 is 2.5 to 11.5 mm, preferably 3.5 to 9.5 mm; height X of the holding portion 6 is 1.8 to 9.5 mm, preferably The holding portion 6 is provided at the bottom of the housing portion 1 and has a height X that is inscribed in the annular device and in contact with the lid portion 5, and preferably the height of the holding portion 6 An annular device in which X is formed at 90 to 100% of the depth Y of the housing portion 1 and the volume B of the holding portion 6 is formed at 50 to 80% of the volume A of the housing portion 1 Blister container.

In the blister container for an annular device according to one aspect of the present invention, since the movement of the accommodated annular device in the housing portion of the annular device is suppressed, the occurrence of inversion and twisting can be reduced. The degree of reduction in the occurrence of inversion and twisting of the annular device can be evaluated by the stability and the inversion described in the examples described later. The blister container for an annular device according to one aspect of the present invention preferably has high stability, more preferably 95% or more, and still more preferably 99% or more. It is further preferred that Further, the blister container for an annular device according to one aspect of the present invention preferably has low invertibility, more preferably less than 5%, and still more preferably less than 1%.

Hereinafter, the present invention will be more specifically described by way of examples. However, the present invention is not limited to these examples, and the present invention can take various aspects as long as the problems of the present invention can be solved. it can.

The blister container for an annular device of the embodiment and the comparative example as illustrated in FIGS. 1 to 5 includes the height X of the holder, the depth Y of the holder, the gap Z between the holder and the lid, and the holder. The volume ratio between the part volume A and the holding part volume B, the height m of the inclined support and the height n of the angular support were prepared with the values shown in Table 1. The annular device used a 2-hydroxy methacrylate polymer with an inner diameter of 13 mm and an outer diameter of 18 mm. The blister containers for annular devices of Examples 1 and 2 and Comparative Examples 1 and 2 were prepared by pouring polypropylene into a mold formed in the shape of Table 1 below, and heating at 60 ° C. for about 6 hours to 12 hours.

Example 1 and Comparative Example 1 are containers of the first form shown in FIGS. 1 to 3, wherein the shape of the holding portion is a single hemispherical shape, and the height m of the inclined support is the height of the angular support This is the same form as Here, in Example 1 and Comparative Example 1, the depths Y of the housing portions are all the same, and only the height X of the holding portion is different. In Example 1, the height X of the holding portion is the same as the depth Y of the containing portion, that is, the gap Z between the holding portion and the lid is zero, and the holding portion volume B relative to the containing portion volume A The percentage of is 75%. On the other hand, in Comparative Example 1, the height X of the holder is 64.9% of the depth Y of the housing, and the gap Z between the holder and the lid is 1.3 mm. The ratio of the holding portion volume B to the holding portion volume A is 48.5%.

Example 2 and Comparative Example 2 are containers of the second form shown in FIGS. 4 to 5, in which the shape of the holding portion is a combination of a truncated cone shape, and the height m of the inclined support portion is a square support portion. The height is 0.05 mm (101%) higher than the height n. Here, in Example 2 and Comparative Example 2, the depth Y of the accommodation portion is the same, and only the height X of the holding portion is different. In Example 2, the height X of the holder is lower than the depth Y of the housing (91.9%), and the gap Z between the holder and the lid is 0.3 mm. The ratio of the holding part volume B to the containing part volume A is 60%. On the other hand, in Comparative Example 2, the height X of the holding portion is very low 27% with respect to the depth Y of the housing portion, and the gap Z between the holding portion and the lid is 2.7 mm. The ratio of the holding part volume B to the storage part volume A is 20.5%.

Table 1 below shows the evaluation results of the stationary property with respect to the holding portion, the occurrence of movement out of the holding portion, and the occurrence of inversion for the blister containers for annular devices of Example 1 and Example 2 and Comparative Examples 1 and 2. Show.

The static property was evaluated by grasping the blister container by hand for 20 samples of each annular device blister container, and vibrating the annular device at the holding portion when vibrating vertically and horizontally for 10 seconds. Furthermore, the occurrence rate of inversion was confirmed for the annular device moved away from the holder from the holder through the opening of the annular device.

As shown in Table 1, in the blister containers for annular devices of Examples 1 and 2, the staticability and the reversibility of the annular devices are exceptionally superior to those of the blister containers for the annular devices of Comparative Examples 1 and 2. It was excellent.

Reference Signs List 1 accommodation unit 2 flange unit 3 inclined support unit 4 angular support unit 5 lid 6 holding unit 7 deepest accommodation unit 8 holding unit topmost portion X holding unit height Y accommodation unit depth Z holding unit-lid portion gap A accommodation Part volume B Holder volume m Sloped support height n Square shaped support height

Claims

(A) a storage unit for storing a storage solution and an annular device to be immersed in the storage solution;
(B) a rectangular flange formed around the housing;
(C) an inclined support portion extended and provided so as to be inclined downward from the one short side end portion of the flange portion to the bottom side of the housing portion;
(D) an angular support portion extending downward on the bottom side of the housing portion around the other short side end portion of the flange portion;
(E) a lid that covers the housing;
(F) A convex holding portion provided at the bottom of the housing portion, in contact with the annular device, and having a height at which the top passes through the opening of the annular device and approaches the lid.
And a blister container for annular devices.
The blister container for an annular device according to claim 1, wherein the height of the holding portion is formed at a rate of 90 to 100% with respect to the depth of the housing portion.
The blister container for an annular device according to claim 1, wherein the volume of the holding portion is formed at a rate of 50 to 80% of the volume of the housing portion.