WO2019004989A1 - Method of manufacturing a functional product based on biologically active iodine - Google Patents

Method of manufacturing a functional product based on biologically active iodine Download PDF

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Publication number
WO2019004989A1
WO2019004989A1 PCT/UA2018/000067 UA2018000067W WO2019004989A1 WO 2019004989 A1 WO2019004989 A1 WO 2019004989A1 UA 2018000067 W UA2018000067 W UA 2018000067W WO 2019004989 A1 WO2019004989 A1 WO 2019004989A1
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WO
WIPO (PCT)
Prior art keywords
iodine
biologically active
functional product
fluid medium
mixture
Prior art date
Application number
PCT/UA2018/000067
Other languages
French (fr)
Inventor
Vasyl Mykolayovych MELNICHENKO
Volodymyr Semenovych STELMAKH
Original Assignee
Melnichenko Vasyl Mykolayovych
Stelmakh Volodymyr Semenovych
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Application filed by Melnichenko Vasyl Mykolayovych, Stelmakh Volodymyr Semenovych filed Critical Melnichenko Vasyl Mykolayovych
Publication of WO2019004989A1 publication Critical patent/WO2019004989A1/en

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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52Adding ingredients
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52Adding ingredients
    • A23L2/54Mixing with gases
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16Inorganic salts, minerals or trace elements
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00Treatment of water, waste water, or sewage
    • C02F1/72Treatment of water, waste water, or sewage by oxidation
    • C02F1/76Treatment of water, waste water, or sewage by oxidation with halogens or compounds of halogens
    • C02F1/766Treatment of water, waste water, or sewage by oxidation with halogens or compounds of halogens by means of halogens other than chlorine or of halogenated compounds containing halogen other than chlorine

Definitions

  • This invention relates to food manufacturing industry and, in particular, to methods of enrichment with biologically active iodine of alimentary fluid media, such as potable water, various beverages, fruit, vegetable purees, or other spreadable products, specifically, natural protein products, and, more particularly, the invention relates to a method of manufacturing a functional product that possesses advanced features of polyatomic iodine i Vietnamese bioavailability due to its saturation with hydrogen and, consequently, it accelerates renovation and normalization of the human iodine status as the daily dose of iodine consumption is reduced.
  • biologically active iodine of alimentary fluid media such as potable water, various beverages, fruit, vegetable purees, or other spreadable products, specifically, natural protein products
  • the invention relates to a method of manufacturing a functional product that possesses advanced features of polyatomic iodine i Vietnamese bioavailability due to its saturation with hydrogen and, consequently, it accelerates renovation and normalization of the human iodine status as the daily dose of io
  • the invention is aimed at providing a functional product on the basis of biologically active iodine which is saturated with molecular hydrogen and is characterized with the optimal concentration of ingredients in the proposed mixture so that it would be possible to achieve optimal conditions for assimilation of the biologically active iodine (BAI) in the form of "Iodis-concentrate" (IC) and activation of its effect in the human organism, which, in its turn, enhances the efficacy of iodine status dynamics and lowers the daily dose of iodine consumption.
  • biologically active iodine BAI
  • IC Iodis-concentrate
  • the invention provides a method of manufacturing a functional product based on biologically active iodine which method comprises the steps of
  • free radicals are aggressive oxidizing agents that react with beneficial molecules and cause transformation of a beneficial molecule into a harmful radical.
  • a destructive chain reaction develops and it entails a live cell demolishment. This process is called the "oxidizing stress”.
  • Free radicals provoke cancer, as well as varicose veins, heart diseases, Parkinson's disease, depressions, cataracts, arthritis, asthma, Alzheimer's disease and many other diseases. That is, free radicals accelerate aging of an organism and impede full life on the healthy basis.
  • the saturation of any alimentary fluid medium enriched with BAI of certain concentration, with molecular hydrogen of optimal amount permits to diminish the number of ions lstru that are involved in free radicals destruction.
  • This goal is achieved thanks to the known specific properties of hydrogen molecules (small mass, large penetrability, etc.) which make it possible to faster interact with free radicals and obtain nonhazardous products of the reaction - water.
  • Synergism of action of these two components in the functional product that will be produced in accordance with the proposed method lies in the fact that at saturation with hydrogen at certain concentration the action of iodine atoms is potentiated in the treated medium that contains polyatomic iodine ions due to decreasing the number of free radicals, because a large amount of the BAI (lept) is kept and the organism utilizes this iodine for the intended purpose - the synthesis of iodine hormones.
  • ORP oxidation-reduction potential
  • ORP value in the range from negative value to + 60 mV by changing the ratio of ingredients in the functional product, and subsequently produce a series of target products, in particular, beverages or paste-like products that possess certain therapeutic properties.
  • Efficacy of its action is fixed by the dynamics of the iodine status in the human organism.
  • the iodine status normalization goes on by 10 ⁇ 30 % faster compared with known iodinated products.
  • the synergic mechanism of two ingredients action permits to decrease the daily dose of iodine consumption (lower the beverage price) and increase radio-protective properties of the certain alimentary fluid medium due to faster "filling" of the thyroid body with iodine.
  • the predominant condition for the invention implementation is the selection of the alimentary fluid medium from the group that includes potable water, fruit-and-vegetable beverages, paste-like products from berries, cereals, vegetables, and protein products of natural origin.
  • Example 1 Example 1
  • water treatment purification
  • water treatment purification
  • the "Iodis-concentrate” is added to the purified water to get BAI concentration in the water of 0.01 mg/L to 10 mg/L (depending on the object in view).
  • the mixture undergoes homogenization through its stirring, and then it is held for 4 hours.
  • molecular hydrogen (3 ⁇ 4) of alimentary quality is used.
  • the operation of enrichment of the beverage with natural sugar-containing additives and microelements may be performed at the homogenization stage.
  • “Molodist-zdorovia” beverage is prepared as follows: take 1,000 Liters of water in compliance with DSanPIN 2.2.4-171-10 or mixture of natural juices and add the "Iodis- concentrate" to get the BAI concentration of 0.15 mg/L in the beverage; stir the mixture and cool it to the temperature of + 8°C. Then, saturate the mixture with hydrogen under pressure of 3 ⁇ 5 atm. (standard operation) and bring concentration of the molecular hydrogen in the final product to 10 mg/L. Then the prepared beverage is packaged in container glassware with metal cork (needed to withhold hydrogen).

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Environmental & Geological Engineering (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Water Supply & Treatment (AREA)
  • Hydrology & Water Resources (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a method of manufacturing a functional product based on biologically active iodine. The method consists in enriching an alimentary fluid medium, such as potable water, beverages, paste-like products, fruit-and-vegetable beverages or protein products of natural origin with biologically active iodine and saturating it with molecular hydrogen within optimal limits of the indicated concentrations of these two ingredients. The obtained functional product possesses improved characteristics of polyatomic iodine (I) bioavailability, and implementation of this functional product makes it possible to accelerate renovation and normalization of the human iodine status and at the same time decrease the daily dose of iodine consumption.

Description

Method of manufacturing a functional product based on biologically active iodine
This invention relates to food manufacturing industry and, in particular, to methods of enrichment with biologically active iodine of alimentary fluid media, such as potable water, various beverages, fruit, vegetable purees, or other spreadable products, specifically, natural protein products, and, more particularly, the invention relates to a method of manufacturing a functional product that possesses advanced features of polyatomic iodine i„ bioavailability due to its saturation with hydrogen and, consequently, it accelerates renovation and normalization of the human iodine status as the daily dose of iodine consumption is reduced.
It is known that biologically active iodine (BAI) in the form of "lodis-concentrate" (IC) normalizes parameters of iodine balance in an organism and positively affects the health. Two thirds of the immune system of live organisms depends on their iodine provision. This fact is specifically mentioned in the Report on research and scientific work of the State Institution "V.P. Komisarenko Institute of Endocrinology and Metabolism of the Academy of Medical Sciences of Ukraine", Kyiv, 2001. The research involved school- aged children on the basis of School No. 9 of Minskyi district in the city of Kyiv. 576 children aged from 7 to 17 participated in the study. Though the findings of the study were fairly positive, the problem still remained of the necessity to lower the daily consumption dose without changing the given content of the biologically active iodine.
In order to increase biological activity of iodine it is proposed in UA32044, as an example, to use copper in the content of the iodine concentrate. Although it is a well- known method to increase the iodine biological activity and achieve the stable quality of processed beverage with given purpose-aimed use of several chemical elements, but the high level of daily use in order to maintain the needed content of the BAI still remains.
It is known that when free radicals interact with the BAI, chemical iodine compounds are formed, which escape from the living organism in natural way because the organism uses certain quantity of the BAI (l„) not for the intended purpose, that is not for synthesis of iodine hormones. Consequently, iodine status normalization slows down. The invention is aimed at providing a functional product on the basis of biologically active iodine which is saturated with molecular hydrogen and is characterized with the optimal concentration of ingredients in the proposed mixture so that it would be possible to achieve optimal conditions for assimilation of the biologically active iodine (BAI) in the form of "Iodis-concentrate" (IC) and activation of its effect in the human organism, which, in its turn, enhances the efficacy of iodine status dynamics and lowers the daily dose of iodine consumption.
The invention provides a method of manufacturing a functional product based on biologically active iodine which method comprises the steps of
(a) providing an alimentary fluid medium;
b) enriching the alimentary fluid medium with biologically active iodine to form a mixture with concentration of the biologically active iodine within the range of
0.01 mg/L to 300 mg/L;
c) homogenizing the mixture to obtain a homogenized product containing iodine polyatomic ions;
d) saturating the product containing iodine polyatomic ions ( In) with molecular hydrogen to attain the concentration of the hydrogen in the final product within the range of 0.5 mg/L to 30 mg/L.
It is known that free radicals are aggressive oxidizing agents that react with beneficial molecules and cause transformation of a beneficial molecule into a harmful radical. A destructive chain reaction develops and it entails a live cell demolishment. This process is called the "oxidizing stress". Firstly, cell membranes of a healthy cell become damaged. Free radicals provoke cancer, as well as varicose veins, heart diseases, Parkinson's disease, depressions, cataracts, arthritis, asthma, Alzheimer's disease and many other diseases. That is, free radicals accelerate aging of an organism and impede full life on the healthy basis.
According to the invention the saturation of any alimentary fluid medium enriched with BAI of certain concentration, with molecular hydrogen of optimal amount permits to diminish the number of ions l„ that are involved in free radicals destruction. This goal is achieved thanks to the known specific properties of hydrogen molecules (small mass, large penetrability, etc.) which make it possible to faster interact with free radicals and obtain nonhazardous products of the reaction - water. Synergism of action of these two components in the functional product that will be produced in accordance with the proposed method, lies in the fact that at saturation with hydrogen at certain concentration the action of iodine atoms is potentiated in the treated medium that contains polyatomic iodine ions due to decreasing the number of free radicals, because a large amount of the BAI (l„) is kept and the organism utilizes this iodine for the intended purpose - the synthesis of iodine hormones.
In addition, the synergism of two ingredients action is revealed through the value of the oxidation-reduction potential (ORP) of the product. Indeed, ORP values for basic water are + 194 mV (ORP - meter ORP-2069 with high accuracy of measurement). ORP values for the tap water of the Kyiv water supply network are + 220 ÷ + 350 mV. The product of this invention with two active ingredients has the ORP value of + 57 mV.
It is known that the less the ORP value of the product, the higher its usefulness, and it strengthens the health of live organisms. It is possible to obtain ORP value in the range from negative value to + 60 mV by changing the ratio of ingredients in the functional product, and subsequently produce a series of target products, in particular, beverages or paste-like products that possess certain therapeutic properties.
Efficacy of its action is fixed by the dynamics of the iodine status in the human organism. When using the functional product fabricated under the claimed method, the iodine status normalization goes on by 10 ÷ 30 % faster compared with known iodinated products.
Positive developments concerning more effective normalization of sugar in human blood also exist.
The synergic mechanism of two ingredients action permits to decrease the daily dose of iodine consumption (lower the beverage price) and increase radio-protective properties of the certain alimentary fluid medium due to faster "filling" of the thyroid body with iodine.
When implementing the invention it is possible to add natural sugar additives and/or microelements in the mixture during the homogenization process, and it is practical to cool the homogenized product to temperatures within the range of + 3°C to + 12°C prior to its saturation with hydrogen.
It is very important that the predominant condition for the invention implementation is the selection of the alimentary fluid medium from the group that includes potable water, fruit-and-vegetable beverages, paste-like products from berries, cereals, vegetables, and protein products of natural origin.
Further, the method will be explained by more detailed description with reference to specific Examples. Example 1.
"Vodis" potable water production
First, water treatment (purification) is performed in order to get the water of potable quality.
Then the "Iodis-concentrate" is added to the purified water to get BAI concentration in the water of 0.01 mg/L to 10 mg/L (depending on the object in view).
The mixture undergoes homogenization through its stirring, and then it is held for 4 hours.
Then the mixture (solution) is cooled to + 8°C and saturated with molecular hydrogen to the concentration of 7 mg/L in the final product. The next stage is packaging.
For this purpose molecular hydrogen (¾) of alimentary quality is used.
In order to ameliorate taste characteristics and intensify the beverage effect, the operation of enrichment of the beverage with natural sugar-containing additives and microelements (Se, Cu, Mg and other) may be performed at the homogenization stage.
Example 2.
Fabrication of "Molodist-zdorovia" ("Youth-health") beverage with rejuvenating effect.
"Molodist-zdorovia" beverage is prepared as follows: take 1,000 Liters of water in compliance with DSanPIN 2.2.4-171-10 or mixture of natural juices and add the "Iodis- concentrate" to get the BAI concentration of 0.15 mg/L in the beverage; stir the mixture and cool it to the temperature of + 8°C. Then, saturate the mixture with hydrogen under pressure of 3 ÷ 5 atm. (standard operation) and bring concentration of the molecular hydrogen in the final product to 10 mg/L. Then the prepared beverage is packaged in container glassware with metal cork (needed to withhold hydrogen).
Example 3.
This study was conducted with the purpose to improve human gastrointestinal microflora when using the functional product fabricated in accordance with the claimed method.
A combination of two ingredients in the foreseen beverage positively affects human gastrointestinal microflora. The study was performed on the basis of the test directfed microbial "Enteronormin" (DSTU ISO 7218: 2007) that contains the following bacteria: Enterococcus faecalis, Lactobacillus salivarius and Bacillus subtilis. 1 g of "Enteronormin" + 5 cm3 of the beverage solution were taken (studied). Control: 1 g of "Enteronormin" + 5 cm of the sterile physiological solution. The study was conducted in accordance with the standard procedure. The following findings were obtained:
Figure imgf000006_0001
These results prove the positive bacteriological action of the beverage and its use perspective. Such a beverage is good to effectively fight dysbacteriosis in a live organism (human, animal, birds, etc.).

Claims

1. A method of manufacturing a functional product based on biologically active iodine, the method comprising the following steps:
(a) providing an alimentary fluid medium;
(b) enriching the alimentary fluid medium with biologically active iodine to form a mixture with a concentration of the biologically active iodine within the range of 0.01 mg/L to 300 mg/L;
(c) homogenizing the mixture to obtain a homogenous product containing polyatomic iodine ions (ij);
(d) saturating the product containing polyatomic iodine ions ( with molecular hydrogen to attain the concentration of the hydrogen in the final product within the range of 0.5 mg/L to 30 mg/L.
2. The method of claim 1, wherein the step (c) further comprises adding natural sugar-containing additives and/or microelements to the mixture.
3. The method of claim 1, wherein the step (c) further comprises cooling the homogeneous product to a temperature within the range of 3 °C to 12 °C.
4. The method of any one of claims 1-3, wherein the alimentary fluid medium is selected from the group consisting of potable water, fruit-and-vegetable beverages, pastelike products from berries, cereals, vegetables, and protein products of natural origin.
PCT/UA2018/000067 2017-06-30 2018-06-27 Method of manufacturing a functional product based on biologically active iodine WO2019004989A1 (en)

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UA2017006807 2017-06-30
UAA201706807 2017-06-30

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2362880A (en) * 1998-12-16 2001-12-05 Vasily Nikolaevich Melnichenko Method for the iodination of water and beverages
UA32044U (en) 2008-02-14 2008-04-25 Государственное Учреждение «Институт Наследственной Патологии» Амн Украины Method for separation of dna from leucocytes of peripheral blood
WO2015088378A1 (en) * 2013-12-09 2015-06-18 Владимир Анатольевич БАРАНОВ Non-drinkable artificial food product

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2362880A (en) * 1998-12-16 2001-12-05 Vasily Nikolaevich Melnichenko Method for the iodination of water and beverages
UA32044U (en) 2008-02-14 2008-04-25 Государственное Учреждение «Институт Наследственной Патологии» Амн Украины Method for separation of dna from leucocytes of peripheral blood
WO2015088378A1 (en) * 2013-12-09 2015-06-18 Владимир Анатольевич БАРАНОВ Non-drinkable artificial food product

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Multiphase Flow Dynamics 4", 1 January 2011, SPRINGER BERLIN HEIDELBERG, Berlin, Heidelberg, ISBN: 978-3-642-20749-5, article NIKOLAY IVANOV KOLEV: "Solubility of O2, N2, H2 and CO2 in water - Chapter 11", pages: 209 - 239, XP055516427, DOI: 10.1007/978-3-642-20749-5_11 *

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