WO2019004979A3 - Compositions pharmaceutiques orales solides d'étéxilate de dabigatran - Google Patents
Compositions pharmaceutiques orales solides d'étéxilate de dabigatran Download PDFInfo
- Publication number
- WO2019004979A3 WO2019004979A3 PCT/TR2018/050220 TR2018050220W WO2019004979A3 WO 2019004979 A3 WO2019004979 A3 WO 2019004979A3 TR 2018050220 W TR2018050220 W TR 2018050220W WO 2019004979 A3 WO2019004979 A3 WO 2019004979A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pharmaceutical compositions
- solid oral
- oral pharmaceutical
- dabigatran etexilate
- etexilate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des compositions pharmaceutiques orales solides, comprenant de l'étéxilate de dabigatran sous la forme de la base libre ou sous la forme de sels, de polymorphes, de solvates, d'hydrates ou d'esters pharmaceutiquement acceptables de celui-ci.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18811674.3A EP3621599A2 (fr) | 2017-05-10 | 2018-05-10 | Compositions pharmaceutiques orales solides d'étéxilate de dabigatran |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TR2017/06848A TR201706848A2 (tr) | 2017-05-10 | 2017-05-10 | Dabigatran eteksi̇lat i̇çeren kati oral farmasöti̇k kompozi̇syonlar |
TR2017/06848 | 2017-05-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2019004979A2 WO2019004979A2 (fr) | 2019-01-03 |
WO2019004979A3 true WO2019004979A3 (fr) | 2019-04-11 |
Family
ID=64559741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/TR2018/050220 WO2019004979A2 (fr) | 2017-05-10 | 2018-05-10 | Compositions pharmaceutiques orales solides d'étéxilate de dabigatran |
Country Status (8)
Country | Link |
---|---|
EP (2) | EP3634388A2 (fr) |
AU (1) | AU2018293361B2 (fr) |
BR (1) | BR112019023781A2 (fr) |
CO (1) | CO2019013649A2 (fr) |
EA (1) | EA201992644A1 (fr) |
NZ (1) | NZ759901A (fr) |
TR (2) | TR201706848A2 (fr) |
WO (1) | WO2019004979A2 (fr) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012001156A2 (fr) * | 2010-07-01 | 2012-01-05 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Formes pharmaceutiques posologiques orales comprenant de l'étéxilate de dabigatran et ses sels pharmaceutiquement acceptables |
WO2013124340A1 (fr) * | 2012-02-21 | 2013-08-29 | Laboratorios Del Dr. Esteve, S.A. | Compositions pharmaceutiques orales de dabigatran étexilate |
CN104095830A (zh) * | 2014-05-22 | 2014-10-15 | 万特制药(海南)有限公司 | 一种甲磺酸盐达比加群酯胶囊的制备方法 |
CN104784147A (zh) * | 2014-01-20 | 2015-07-22 | 成都苑东药业有限公司 | 一种甲磺酸达比加群酯胶囊药物组合物及其制备方法 |
EP2929884A1 (fr) * | 2014-04-11 | 2015-10-14 | Sanovel Ilac Sanayi ve Ticaret A.S. | Combinaisons pharmaceutiques de dabigatran et antagonistes du récepteur de h2 |
CN105560206A (zh) * | 2014-10-13 | 2016-05-11 | 重庆圣华曦药业股份有限公司 | 一种达比加群酯胶囊的制备 |
WO2016142821A2 (fr) * | 2015-03-09 | 2016-09-15 | Alphamed Formulations Pvt. Ltd | Compositions contenant un inhibiteur de la thrombine |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE121699A1 (es) | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
DE10337697A1 (de) | 2003-08-16 | 2005-03-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tablette enthaltend 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenyl-amino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester oder dessen Salze |
EP2740471B1 (fr) | 2012-12-07 | 2015-05-27 | Hexal AG | Composition pharmaceutique orale comprenant le dabigatran etexilate |
WO2015145462A1 (fr) | 2014-03-26 | 2015-10-01 | Cadila Healthcare Limited | Compositions pharmaceutiques de dabigatran |
IN2015CH01145A (fr) * | 2015-03-09 | 2016-09-16 |
-
2017
- 2017-05-10 TR TR2017/06848A patent/TR201706848A2/tr unknown
-
2018
- 2018-05-04 TR TR2018/06309A patent/TR201806309A2/tr unknown
- 2018-05-10 NZ NZ759901A patent/NZ759901A/en not_active IP Right Cessation
- 2018-05-10 BR BR112019023781-0A patent/BR112019023781A2/pt not_active Application Discontinuation
- 2018-05-10 EP EP18811675.0A patent/EP3634388A2/fr not_active Withdrawn
- 2018-05-10 EP EP18811674.3A patent/EP3621599A2/fr not_active Withdrawn
- 2018-05-10 EA EA201992644A patent/EA201992644A1/ru unknown
- 2018-05-10 AU AU2018293361A patent/AU2018293361B2/en not_active Ceased
- 2018-05-10 WO PCT/TR2018/050220 patent/WO2019004979A2/fr unknown
-
2019
- 2019-12-03 CO CONC2019/0013649A patent/CO2019013649A2/es unknown
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012001156A2 (fr) * | 2010-07-01 | 2012-01-05 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Formes pharmaceutiques posologiques orales comprenant de l'étéxilate de dabigatran et ses sels pharmaceutiquement acceptables |
WO2013124340A1 (fr) * | 2012-02-21 | 2013-08-29 | Laboratorios Del Dr. Esteve, S.A. | Compositions pharmaceutiques orales de dabigatran étexilate |
CN104784147A (zh) * | 2014-01-20 | 2015-07-22 | 成都苑东药业有限公司 | 一种甲磺酸达比加群酯胶囊药物组合物及其制备方法 |
EP2929884A1 (fr) * | 2014-04-11 | 2015-10-14 | Sanovel Ilac Sanayi ve Ticaret A.S. | Combinaisons pharmaceutiques de dabigatran et antagonistes du récepteur de h2 |
CN104095830A (zh) * | 2014-05-22 | 2014-10-15 | 万特制药(海南)有限公司 | 一种甲磺酸盐达比加群酯胶囊的制备方法 |
CN105560206A (zh) * | 2014-10-13 | 2016-05-11 | 重庆圣华曦药业股份有限公司 | 一种达比加群酯胶囊的制备 |
WO2016142821A2 (fr) * | 2015-03-09 | 2016-09-15 | Alphamed Formulations Pvt. Ltd | Compositions contenant un inhibiteur de la thrombine |
Non-Patent Citations (1)
Title |
---|
DATABASE WPI Section Ch Week 201675, Derwent World Patents Index; Class A96, AN 2016-637397, XP002789451, BALANAGU H B; BALEBOINA S; BEJAWADA S; CHERUVU R; HILL L A: "Capsule dosage form of direct thrombin inhibitor, useful e.g. for treating deep venous thrombosis and pulmonary embolism, and for reducing risk of stroke and systemic embolism, comprises two types of solid unit dosage forms" * |
Also Published As
Publication number | Publication date |
---|---|
EA201992644A1 (ru) | 2020-04-07 |
CO2019013649A2 (es) | 2020-05-15 |
TR201806309A2 (tr) | 2018-11-21 |
AU2018293361A1 (en) | 2020-01-02 |
NZ759901A (en) | 2021-12-24 |
TR201706848A2 (tr) | 2018-11-21 |
BR112019023781A2 (pt) | 2020-06-02 |
EP3621599A2 (fr) | 2020-03-18 |
EP3634388A2 (fr) | 2020-04-15 |
WO2019004979A2 (fr) | 2019-01-03 |
AU2018293361B2 (en) | 2021-09-16 |
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