WO2018208013A1

WO2018208013A1 - Microneedle

Info

Publication number: WO2018208013A1
Application number: PCT/KR2018/003955
Authority: WO
Inventors: 양승윤; 이승수; 이강오
Original assignee: 부산대학교 산학협력단; 주식회사 에스엔비아
Priority date: 2017-05-08
Filing date: 2018-04-04
Publication date: 2018-11-15
Also published as: KR20180123260A; KR102014592B1

Abstract

The present invention relates to a microneedle patch and, more specifically, to microneedles which are easily prevented from falling off when inserted into the skin, by means of enhancing the shape of the microneedles applied to a patch. Microneedles according to the present invention comprise: a patch portion; and a plurality of microneedles extending on one surface of the patch portion. The microneedles are provided in a reverse taper form in which the cross-sectional area gradually increases toward the end part. The microneedles according to the present invention can be prevented from falling off the skin. The microneedles according to the present invention can easily and selectively be broken off after the insertion into the skin. The microneedles according to the present invention are formed in a reverse taper form easily preventing the microneedles from falling off the skin, and the entire cross-sectional area can be maintained to be uniform with respect to the length direction and thus the strength can be maintained.

Description

Microneedle

The present invention relates to a microneedle patch, and more particularly to a microneedle that can easily prevent the departure when inserted into the skin by improving the shape of the microneedle applied to the patch.

Microneedle applied to the microneedle patch, the tip is formed on the upper end and the body is formed in a straight line, when inserted into the skin easily detached.

In general, when the skin is torn or cut, it is prevented by using a stapler to easily prevent the opening, but due to the microneedle patch attaching easy to attach, it is possible to fix the opening without deepening the wound. However, this requires solving the problem of microneedles detaching easily from the skin.

In this regard, referring to the prior art, as shown in FIG. 1, U.S. Patent No. 8834423 and U.S. Patent No. 8353861 disclose microneedles having a reverse taper shape. This acts as a notch, weakens the strength and easily breaks.

Accordingly, the present invention has been made to solve the problems of the prior art as described above, and an object thereof is to provide a microneedle structure that can prevent the departure from the skin.

It is another object of the present invention to provide a microneedle structure that can be easily broken after insertion of the microneedle into the skin.

In addition, the present invention comprises a microneedle of the reverse taper form that can easily prevent the departure from the skin, to provide a microneedle structure that can maintain the strength by maintaining a constant overall cross-sectional area relative to the longitudinal direction of the object There is this.

The problem to be solved by the present invention is not limited to the above-mentioned problem, another problem to be solved by the present invention not mentioned here is those skilled in the art to which the present invention pertains from the following description Will be clearly understood.

In the present invention, the microneedle comprises a patch portion and a plurality of microneedles extending on one surface of the patch portion, wherein the microneedle is a head portion and a conical end portion to facilitate penetration into the skin and the It extends from the head portion to the patch portion, and comprises a body portion which is formed to be concave inward.

In the present invention, the microneedle is effective to prevent the departure from the skin.

In addition, the microneedle according to the present invention, after insertion into the skin, there is an effect that can be easily broken selectively.

In addition, the microneedle according to the present invention is configured in the form of a reverse tape that can easily prevent the departure from the skin, there is an effect that can maintain the strength by maintaining a constant overall cross-sectional area based on the longitudinal direction.

Figure 1 (a) shows a representation of US Patent No. 8834423.

Figure 1 (b) shows a representation of US Patent No. 8353861.

Figure 2 shows in a perspective view the form applied to the microneedle patch according to the present invention.

Figure 3 shows a front cross-sectional view of the recessed type needle according to the present invention.

Figure 4 shows a front cross-sectional view of the stapler type needle according to the present invention.

Figure 5 (a) shows a front cross-sectional view of the microneedle of the reverse taper shape according to another embodiment of the present invention.

Figure 5 (b) shows a side cross-sectional view of the microneedle of the reverse taper type according to another embodiment of the present invention.

Figure 5 (c) shows a cross-sectional plan view of the microneedle of the reverse taper shape according to another embodiment of the present invention.

Specific matters including the problem to be solved, the solution to the problem, and the effects of the present invention as described above are included in the embodiments and drawings to be described below. Advantages and features of the present invention and methods for achieving them will be apparent with reference to the embodiments described below in detail with the accompanying drawings.

As shown in FIG. 2, the microneedle according to the present invention includes a patch part 1 and a plurality of microneedles 2 extending on one surface of the patch part 1, and the microneedle ( 2) is characterized in that it is provided in the form of a reverse taper of the cross-sectional area increases toward the end.

First, the patch 1 is provided with a plate-like flexible material.

The patch 1 may be generally formed in a general form used for patching the microneedle 2, and a film layer having a detachable form may be further formed to protect the surface.

Next, the microneedles 2 are provided in plural in a form extending from one surface of the patch part 1.

Specifically, the microneedle 2 may be formed to extend from the patch portion 1, the end may be provided in a conical shape to facilitate insertion into the skin.

The microneedle 2 is excellent in biocompatibility as an application to be inserted into the skin, and may optionally be composed of a biodegradable material.

Specifically, the microneedle 2 is composed of a head portion 31 and the body portion (32).

The head portion 31 is a portion corresponding to the end of the microneedle 2, is formed in a conical shape to facilitate penetration into the skin.

Next, the body portion 32 is a portion extending from the head portion 31 to the patch portion 1, and the middle portion is formed to be concave inward with respect to the longitudinal direction.

Since the body portion 32 is formed concave, when the microneedle 2 penetrates the skin by attaching the patch portion 1 to the skin, the body portion is formed concave by elasticity of the skin. The boundary layer of the skin is formed in close contact with 32 to prevent the microneedle 2 from being easily separated.

In addition, the concave portion of the body portion 32 is not formed in the corner of the corner shape is formed smoothly in the shape of an arch, so that when entering or releasing to the skin, to maintain a sufficient strength to prevent breakage Can be.

If the concave portion is formed in the middle portion of the body portion 32, as shown in Fig. 1 (a), (b), when formed in an angular shape, the same effect as the notch is formed by itself is angled When the strength of the part is drastically lowered, the injection into the skin is more likely to be broken, so that the injection is difficult, and even after the injection, it may be easily broken, which may make recovery difficult.

The microneedle 2 may be intentionally broken after the injection into the skin for the purpose of administering the drug, but as described above, when the angular portion is formed in the body part 32, Penetration into the skin itself is not easy.

Therefore, the body portion 32 is preferably configured so that the angle of the corner shape is not formed.

The microneedle 2 according to the present invention can be used for two main purposes, and may be composed of any one of the recessed type needle 3 and the stapler type needle.

First, the immersion type needle (3), after penetrating the microneedle (2) into the skin, and absorbs a portion of the microneedle (2) provided with a biodegradable material with the drug in the skin in the skin to absorb In order to ensure that, after the microneedle (2) is put into the skin, when the lateral pressure is applied, the body is easily broken so that it can remain in the skin.

Specifically, the body portion 32 applied to the recessed type needle 3, as shown in Figure 3, including a 1-1 curvature 321 to 1-4 curvature 324 It is composed.

First, when the first-first curvature 321 is divided into four equal parts, the first-curvature 321 is positioned below the head 31 and has a radius of curvature of 0.65 to 0.75 mm.

Next, the first 1-2 curvature portion 322 is located in the lower portion of the first curvature portion when the body portion 32 is divided into four, the radius of curvature is 0.36 ~ 0.45mm.

Next, the first 1-3 curvature 323 is located below the second curvature, when the body 32 is divided into four, the radius of curvature is 0.30 ~ 0.35mm.

Next, when the body portion 32 is divided into four portions, the first to fourth curvature portions 324 are positioned below the third curvature portion and connected to the patch portion 1, and the radius of curvature is 0.20. It consists of ~ 0.29mm.

In conclusion, the radius of curvature becomes smaller toward the first-curvature 324 from the first-first curvature 321.

For this reason, the thickness of the first 1-2 curvature 322 to the first 1-3 curvature 323 gradually becomes thin, when the immersion type needle (3) is inserted into the skin, when the lateral pressure is applied In one or more of the 1-2nd curvature 322 and the 1-3th curvature 323 may be easily broken.

Next, the stapler type needle (4), the microneedle (2) penetrates into the skin for the purpose of attaching and holding the patch (1) to the skin so as not to open any more open wounds, etc. of the skin After that, it is configured not to be easily detached and configured to prevent the detachment of the patch 1 from the skin.

Specifically, the body portion 42 applied to the stapler type needle 4, as shown in Figure 4, includes a 2-1 curvature portion 421 to 2-4 curvature portion 424 It is configured by.

First, the 2-1nd curvature portion 421 is located below the head portion 41 when the body portion 42 is divided into four parts, and the radius of curvature is 0.15 to 0.25 mm.

Next, the second-2 curvature 422 is located below the second-1 curvature 421 when the body 42 is divided into four, and has a radius of curvature of 0.30 to 0.35 mm. It is composed.

Next, when the body portion 42 is divided into four parts, the 2-3 curvature 423 is located below the second 2-2 curvature 422 and has a radius of curvature of 0.36 to 0.45 mm. It is composed.

Next, the second-4 curvature 424 is located in the lower portion of the 2-3 curvature 423 when the body portion 42 is divided into four, and is connected to the patch 1. The radius of curvature is composed of 0.70 to 1.20 mm.

In conclusion, the radius of curvature increases from the 2-1st curvature 421 toward the 2-4th curvature 424.

For this reason, when the stapler type needle 4 is inserted into the skin, the strength is not broken, and at least one of the 2-1 curvature 421 and the 2-2 curvature 422 is maintained. The surface of the skin is caught by the elasticity can be prevented from being easily separated from the skin.

In another embodiment, the microneedle 2 has a head portion 5 and a patch portion from the head portion 5 forming a conical end portion to facilitate penetration into the skin, as shown in FIG. 5. It extends to (1), but the transverse diameter becomes wider from the upper side to the lower side, and the longitudinal diameter is composed of a body portion 6 in the form of narrowing.

Specifically, FIG. 2A illustrates a front view of the microneedle 2 according to another embodiment, and FIG. 2B illustrates a side view of the microneedle 2 according to another embodiment. It is shown.

(C) of FIG. 2 shows a cross section in the plane of A-A ', B-B', C-C 'in plan view.

The body portion 6 is configured in an inverted taper shape in which the diameter decreases as the lateral cross section is directed downward, but in the forward cross section, it is preferable that the body portion 6 is configured in a tapered form in which the diameter is increased as it is directed downward.

Due to the configuration as described above, when the microneedle (2) is put into the skin, the head portion (5) is configured to not be easily caught off the skin, the cross-sectional area of the body 6 is kept constant To maintain strength.

As such, the technical configuration of the present invention described above can be understood by those skilled in the art that the present invention can be implemented in other specific forms without changing the technical spirit or essential features of the present invention.

Therefore, the above-described embodiments are to be understood as illustrative and not restrictive in all respects, and the scope of the present invention is indicated by the following claims rather than the detailed description, and the meaning and scope of the claims and their All changes or modifications derived from an equivalent concept should be construed as being included in the scope of the present invention.

[Description of the code]

1 patch

2: microneedle

3: immersion type needle

31: head

32: body part

321: first curvature

322: first 1-2 curvature

323: first to third curvature

324: 1-4 the curvature

4: Stapler Type Needle

41: head

42: body part

421 second curvature

422: 2-2 curvature

423: second 2-3 curvature

424: 2-4nd curvature

5: head

6: body part

Claims

Patch portion;

Includes; a plurality of microneedles extending on one surface of the patch portion,

The microneedle,

A head portion which forms a conical end portion to facilitate penetration into the skin; And

And a body portion extending from the head portion to the patch portion, the body portion being concave inwardly.
The method of claim 1,

The microneedle,

After penetrating the skin, the break-in type needle that is broken and remaining in the skin; And

A stapler type needle configured to fix the damaged skin so as not to be easily separated from the skin after penetration into the skin; Microneedle, characterized in that can be configured to any one of.
The method of claim 2,

The body portion applied to the recessed type needle,

A first-first curvature part disposed below the head part when the body part is divided into four parts;

When the body portion is divided into four, the first 1-2 curvature portion located below the first curvature portion;

When the body portion is divided into four portions, the first to third curvature portions positioned under the second curvature portion;

When the body portion is divided into four, 1-4 curvature portion which is located below the third curvature portion and connected to the patch portion;

The radius of curvature decreases as it goes from the first-first curvature to the first-fourth curvature, and when the recessed type needle is inserted into the skin, the first-two curvature and the first-three curvature Microneedle, characterized in that the breakage occurs easily in any one or more of the.
The method of claim 2,

The body portion applied to the stapler type needle,

A second-first curvature part disposed below the head part when the body part is divided into four parts;

A second-2 curvature part disposed below the second-1 curvature part when the body part is divided into four parts;

A second 2-3 curvature portion disposed below the second-2 curvature portion when the body portion is divided into four parts;

When the body portion is divided into four, the 2-4 curvature portion which is located under the 2-3 curvature portion and connected to the patch portion;

The radius of curvature increases from the 2-1 curvature to the 2-4 curvature, so that when the stapler type needle is inserted into the skin, any one of the 2-1 curvature and the 2-2 curvature The microneedle, characterized in that the hook is formed on the skin from the above it is difficult to escape from the skin.
The method of claim 1,

The microneedle,

A head portion which forms a conical end portion to facilitate penetration into the skin; And

The body is provided extending from the head portion to the patch portion, the transverse diameter becomes wider and the longitudinal diameter becomes narrower from the top toward the lower portion; microneedle, characterized in that consisting of.