WO2018201881A1 - Composition fongicide et son utilisation - Google Patents

Composition fongicide et son utilisation Download PDF

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Publication number
WO2018201881A1
WO2018201881A1 PCT/CN2018/083143 CN2018083143W WO2018201881A1 WO 2018201881 A1 WO2018201881 A1 WO 2018201881A1 CN 2018083143 W CN2018083143 W CN 2018083143W WO 2018201881 A1 WO2018201881 A1 WO 2018201881A1
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WIPO (PCT)
Prior art keywords
spp
component
composition
puccinia
boscalid
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PCT/CN2018/083143
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English (en)
Inventor
James Timothy Bristow
Original Assignee
Jiangsu Rotam Chemistry Co., Ltd.
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Application filed by Jiangsu Rotam Chemistry Co., Ltd. filed Critical Jiangsu Rotam Chemistry Co., Ltd.
Priority to CN201880025099.7A priority Critical patent/CN110505806B/zh
Publication of WO2018201881A1 publication Critical patent/WO2018201881A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof

Definitions

  • the present invention relates to a synergistic fungicidal composition, in particular a composition comprising three active components which exhibit synergy when combined.
  • the present invention further relates to the use of such a combination of active ingredients in preventing and/or treating fungal infestations in plants and plant parts, as well as a method of preventing and/or treating fungal infestations in plants and plant parts.
  • the present invention also relates to the treatment of seeds, foliage and to soil applications.
  • Fungal diseases represent a major threat to economically important agricultural crops, such as cereals and leguminous plants.
  • the yields of plants, for example, sugarcane and soybean are adversely impacted by fungal infestations.
  • fungicidal active ingredients have been shown to be more effective in combination than when applied individually. This effect is referred to as "synergism" .
  • synergism As defined in the Herbicide Handbook of the Weed Science Society of America, Seventh Edition, 1994, page 318, 'synergism' is an interaction of two or more factors such that the effect when combined is greater than the predicted effect based on the response to each factor applied separately.
  • the present invention is based on the surprising discovery that certain fungicides display a synergistic effect when applied in combination.
  • fungicidal active ingredients employed in the present invention are independently known in the art for their use in plant protection. Specific compounds are disclosed in The Pesticides Manual, Twelfth Edition, 2000, published by The British Crop Protection Council. Many of the compounds are also commercially available.
  • Boscalid is a carboxamide fungicide having the chemical name of 2-chloro-N- (4’chloro [1, 1’biphenyl] -2-yl) -3-pyridinecarboxamide. Boscalid was first described in US 5,330,995.
  • Metconazole belongs to the triazole family of compounds, which is a class of systemic fungicides that enter the plant and spread from the site of application to untreated or newly grown area, killing existing fungi and/or protecting the plant from future attacks.
  • the mechanism of action of these fungicides includes their ability to interfere with the biosynthesis of biosteroids or to inhibit the biosynthesis of ergosterol.
  • Ergosterol is needed for membrane structure and function within the fungal cells and is essential for the development of functional cell walls by fungi. Therefore, application of triazoles results in abnormal fungal growth and eventually death.
  • Pyraclostrobin, picoxystrobin, azoxystrobin and dimoxystrobin belong to the class of strobilurin-type fungicides, which is a well-known group of fungicides having a broad spectrum of disease control.
  • the compounds are extracted from the fungus Strobilurus tenacellus and have a suppressive effect on other fungi, reducing competition for nutrients.
  • the compounds inhibit electron transfer between cytochrome b and cytochrome C 1 at the ubiquinol oxidising site in mitochondria, disrupting the metabolism and preventing growth of the target fungi.
  • WO 2007/134776 relates to combinations of fungicidal active agents.
  • WO 2007/134776 is specifically concerned with combinations comprising the triazolopyrimidine derivative 5-chloro-7- (4-methylpiperidin-1-yl) -6- (2, 4, 6-trifluorophenyl) [1, 2, 4] triazolo [1, 5-a] pyrimidine, boscalid and at least one of fenpropimorph, metrafenone, metconazole and dimoxystrobin.
  • the present invention provides a synergistic composition and a method to prevent, control and/or treat fungal infestations.
  • the present invention provides the advantages of reducing the rates of application of the active ingredients, widening their spectrum of activity, increasing the speed of action of the fungicides and increasing their efficacy.
  • the present invention provides a synergistic fungicidal composition comprising:
  • component (A) boscalid
  • component (B) metconazole
  • component (C) one or more strobilurin-type fungicides selected from pyraclostrobin, picoxystrobin, azoxystrobin and dimoxystrobin.
  • the present invention provides a method for preventing, controlling and/or treating fungal infestations in plants, the method comprising applying to the plants, plant parts and/or their surroundings:
  • component (A) boscalid
  • component (B) metconazole
  • component (C) one or more strobilurin-type fungicides selected from pyraclostrobin, picoxystrobin, azoxystrobin and dimoxystrobin.
  • the present invention provides the use of:
  • component (A) boscalid
  • component (B) metconazole
  • component (C) one or more strobilurin-type fungicides selected from pyraclostrobin, picoxystrobin, azoxystrobin and dimoxystrobin
  • component (A) boscalid component (B) metconazole, and component (C) one or more of pyraclostrobin, picoxystrobin, azoxystrobin and dimoxystrobin on the target plants, plant parts and/or their surroundings, particularly on cereals, cucurbitaceae, fruits, leguminous plants, oil plants and vegetables, an excellent performance in preventing, controlling and/or treating fungal infestations may be observed.
  • the present invention employs a combination of active ingredients consisting of the combination of component (A) boscalid, component (B) metconazole, and component (C) one or more of pyraclostrobin, picoxystrobin, azoxystrobin and dimoxystrobin.
  • the active ingredients may be employed together, for example as a composition comprising components (A) , (B) and (C) , separately, for example by way of two or more compositions containing one or two of (A) , (B) and (C) , or a combination of the aforementioned.
  • the active ingredients may be applied to a locus to be treated simultaneously and/or successively.
  • the active ingredients may be applied in any order.
  • the synergistic effect achieved by combining the components (A) , (B) and (C) by way of the present invention can provide advantages over the use of the individual components.
  • the rates of application of the individual components can be markedly reduced, compared with using the components individually, while maintaining a high level of fungicidal efficacy.
  • the combination can have a considerably broader spectrum of fungi against which it is effective than that of the components used alone.
  • the combination can have the potential to control fungal infestations at low application rates, at which the individual compounds alone are ineffective.
  • the combination can have a speed of action which is faster than that which would have been predicted from the speed of the individual components.
  • the present invention employs an effective amount of components (A) , (B) and (C) .
  • the term "effective amount” means the quantity of such a compound or combination of such compounds that is capable of preventing, controlling and/or treating the target fungal infestations of the target plants.
  • Plant refers to all plant and plant populations such as desired and undesired wild plants or crop plants.
  • Plant parts refers to all parts and organs of plants, such as shoot, leaves, needles, stalks, stems, fruit bodies, fruits, seeds, roots, tubers and rhizomes.
  • Harvested materials, and vegetative and generative propagation materials for example, cutting, tubers, meristem tissue, rhizomes, offsets, seeds, single and multiple plant cells and any other plant tissues, are also included.
  • the word “surrounding” or “locus” refers to the place on which the plants are growing, the place on which the plant propagation materials of the plants are sown or the place on which the plant propagation materials of the plants will be sown.
  • the components (A) and (B) , boscalid and metconazole, may be employed in the composition of the present invention in any suitable amount, and are generally present in a total amount of from about 5%to about 85%by weight of the composition, preferably from about 10%to about 70%by weight of the composition, more preferably from about 15%to about 60%be weight or from about 20%to about 55%by weight of the composition.
  • boscalid may be present in the composition of the present invention in any suitable amount, and is generally present in an amount of from about 1%to about 80%by weight of the composition, preferably from about 5%to about 75%or from about 10%to about 65%by weight of the composition, more preferably from about 10%to about 50%by weight of the composition. In some preferred embodiments, boscalid is present in an amount of from about 15%, 20%, 25%, 30%or 50%by weight of the composition.
  • Metconazole may be present in the composition of the present invention in any suitable amount, and is generally present in an amount of from about 1%to about 70%by weight of the composition, preferably from about 1%to about 60%or from about 1%to about 50%by weight of the composition, more preferably from about 1%to about 40%by weight of the composition, still more preferably from about 1%to about 30%by weight of the composition, still more preferably from about 1%to about 20%by weight of the composition. In some preferred embodiments, metconazole is present in an amount of from about 4%, 5%, 8%, 10%or 12%by weight of the composition.
  • the component (C) one or more of pyraclostrobin, picoxystrobin, azoxystrobin and dimoxystrobin may be present in the composition of the present invention in any suitable amount, and is generally present in an amount of from about 1%to about 70%by weight of the composition, preferably from about 1%to about 60%or from about 1%to about 50%by weight of the composition, more preferably from about 1%to about 40%by weight of the composition, still more preferably from about 1%to about 30%by weight of the composition, still more preferably from about 5%to about 20%by weight of the composition.
  • the weight percentages of the components in the composition are independently: from about 15%to about 50%of boscalid; from about 4%to about 12%of metconazole; and from about 5%to about 20%of strobilurin by weight of the composition; the strobilurin being one or more of pyraclostrobin, picoxystrobin, azoxystrobin or dimoxystrobin.
  • the components (A) , (B) and (C) together may be present in the composition in any suitable amount, and are generally present in an amount of from about 2%to about 95%by weight of the composition, preferably from about 20%to about 80%by weight of the composition more preferably from about 25%to about 70%, even more preferred from about 30%to about 65%by weight of the composition.
  • the components (A) and (B) may be present in the composition or otherwise applied in any amounts relative to each other, to provide the enhanced or synergistic effect of the mixture.
  • the weight ratio of the components (A) and (B) as used may be in the range of from about 50: 1 to about 1: 50, preferably from about 45: 1 to about 1: 15, more preferably from about 40: 1 to about 1: 1, even more preferably from about 35: 1 to about 1: 1, still more preferably from about 15: 1 to about 1: 1.
  • the weight ratio of the components (A) and (B) as used is about 30: 1, or 25: 1 or 20: 1 or 15: 1 or 13: 1 or 9: 1 or 8: 1 or 7: 1 or 6: 1 or 5: 1 or 4: 1 or 3: 1 or 2: 1 or 1: 1.
  • the components (A) , (B) and (C) may be present in the composition or otherwise applied in any amounts relative to each other, to provide the enhanced or synergistic effect of the mixture.
  • the weight ratio of the combined components (A) and (B) to the component (C) as used may be in the range of from about 50: 1 to about 1: 50, preferably from about 45: 1 to about 1: 15, more preferably from about 40: 1 to about 1: 1, even more preferably from about 35: 1 to about 1: 1, still more preferably from about 11: 1 to about 1: 1.
  • the weight ratio of the combined components (A) and (B) to the component (C) as used is about 30: 1, or 25: 1 or 20: 1 or 15: 1 or 10: 1 or 9: 1 or 8: 1 or 7: 1 or 6: 1 or 5: 1 or 4: 1 or 3: 1 or 2: 1 or 1: 1.
  • compositions of the present invention may be produced in conventional manner and provided in any suitable formulation, for example by mixing component (A) boscalid, component (B) metconazole and component (C) the strobilurin, together with one or more auxiliaries appropriate for the type of formulation.
  • auxiliaries employed in the composition will depend upon the type of formulation and/or the manner in which the formulation is to be applied by the end user. Formulations incorporating the composition of the present invention are described hereinafter. Suitable auxiliaries which may be comprised in the composition according to the invention are all customary formulation adjuvants or components, such as extenders, carriers, solvents, surfactants, stabilizers, anti-foaming agents, anti-freezing agents, preservatives, antioxidants, colorants, thickeners, solid adherents and inert fillers. Such auxiliaries are known in the art and are commercially available. Their use in the formulation of the compositions of the present invention will be apparent to the person skilled in the art.
  • Formulation types suitable for the compositions of the present invention include water-soluble concentrates (SL) , emulsifiable concentrates (EC) , emulsions (EW) , micro-emulsions (ME) , suspension concentrates (SC) , oil-based suspension concentrates (OD) , flowable suspensions (FS) , water-dispersible granules (WG) , water-soluble granules (SG) , water-dispersible powders (WP) , water soluble powders (SP) , granules (GR) , encapsulated granules (CG) , fine granules (FG) , macrogranules (GG) , aqueous suspo-emulsions (SE) , capsule suspensions (CS) and microgranules (MG) .
  • SL water-soluble concentrates
  • EC emulsifiable concentrates
  • EW emulsions
  • ME micro-emul
  • WG water-dispersible granules
  • SC aqueous suspension concentrates
  • EC emulsifiable concentrates
  • SL water-soluble concentrates
  • the fungicidal composition may comprise one or more inert fillers.
  • inert fillers are known in the art and available commercially.
  • Suitable fillers in the form of a solid include, for example, natural ground minerals, such as kaolins, aluminas, talc, chalk, quartz, attapulgite, montmorillonite, and diatomaceous earth, or synthetic ground minerals, such as highly dispersed silicic acid, aluminum oxide, silicates, and calcium phosphates and calcium hydrogen phosphates.
  • Suitable inert fillers for granules include, for example, crushed and fractionated natural minerals, such as calcite, marble, pumice, sepiolite, and dolomite, or synthetic granules of inorganic and organic ground materials, as well as granules of organic material, such as sawdust, coconut husks, corn cobs, and tobacco stalks.
  • the fungicidal compositions of the present invention optionally include one or more surfactants, which are preferably non-ionic, cationic and/or anionic in nature, and surfactant mixtures which have good emulsifying, dispersing and wetting properties, depending on the nature of the active compound to be formulated.
  • surfactants are known in the art and are commercially available.
  • the surfactant can be an emulsifier, dispersant or wetting agent of ionic or nonionic type.
  • examples which may be used are salts of polyacrylic acids, salts of lignosulphonic acid, salts of phenylsulphonic or naphthalene sulphonic acids, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted phenols, especially alkylphenols, sulphosuccinic ester salts, taurine derivatives, especially alkyltaurates, or phosphoric esters of polyethoxylated phenols or alcohols.
  • the presence of at least one surfactant is generally required when the active compound and/or the inert carrier and/or auxiliary/adjuvant are insoluble in water and the vehicle for the final application of the composition is water.
  • Suitable surfactants are polyoxyethylated (POE) sorbitan esters, such as POE (20) , sorbitan trioleate and polyoxyethylated (POE) sorbitol esters, such as POE (40) , sorbitol hexaoleate.
  • POE (20) sorbitan trioleate is commercially available under the tradenames ATLAS G1086 and CIRRASOL G1086 marketed by UniqEMA.
  • Combinations of a POE sorbitan ester with a POE sorbitol ester allow the HLB (hydrophilic-lipophilic balance) value of the surfactant to be optimized, so as to obtain the highest quality emulsion (smallest suspended droplets) when the composition is added to water. Higher quality of emulsions typically leads to optimal fungicidal performance.
  • Suitable anionic surfactants can be both so-called water-soluble soaps and water-soluble synthetic surface-active compounds.
  • Soaps which may be used in the composition are the alkali metal, alkaline earth metal or substituted or unsubstituted ammonium salts of higher fatty acid (C 10 -C 22 ) , for example the sodium or potassium salt of oleic or stearic acid, or of natural fatty acid mixtures.
  • the amount of surfactant present in the composition will depend upon such factors as the type of formulation employed.
  • the fungicidal compositions of the present invention optionally further comprise one or more polymeric stabilizers.
  • the suitable polymeric stabilizers that may be used in the present invention include, but are not limited to, polypropylene, polyisobutylene, polyisoprene, copolymers of monoolefins and diolefins, polyacrylates, polystyrene, polyvinyl acetate, polyurethanes or polyamides. Suitable stabilizers are known in the art and commercially available.
  • surfactants and polymeric stabilizers mentioned above are generally believed to impart stability to the composition, in turn allowing the composition to be formulated, stored, transported and applied.
  • Suitable anti-foaming agents include all substances which can normally be used for this purpose in agrochemical compositions. Suitable anti-foaming agents are known in the art and are available commercially. Particularly preferred anti-foaming agents are mixtures of polydimethylsiloxanes and perfluroalkyl phosphonic acids, such as the silicone anti-foaming agents available from GE or Compton.
  • Suitable organic solvents that may be used in the compositions may be selected from all customary organic solvents, which thoroughly dissolve one or more of the active compounds employed. Again, suitable organic solvents for the active compounds in the compositions of the present invention are known in the art. The following may be mentioned as being preferred: N-methyl pyrrolidone, N-octyl pyrrolidone, cyclohexyl-1-pyrrolidone; or a mixture of paraffinic, isoparaffinic, cycloparaffinic and aromatic hydrocarbons, such as SOLVESSO TM 200. Suitable solvents are commercially available.
  • Suitable preservatives include all substances which can normally be used for this purpose in agrochemical compositions of this type and again are well known in the art. Suitable preservatives that may be mentioned include tolylfluanid, such as (available commercially from Bayer AG) , and benzisothiazolinone, such as (available commercially from Bayer AG) .
  • Suitable antioxidants are all substances which can normally be used for this purpose in agrochemical compositions, as is known in the art. Preference is given to butylated hydroxytoluene.
  • Suitable thickeners include all substances which can normally be used for this purpose in agrochemical compositions. Suitable thickeners include, for example xanthan gum, PVOH, cellulose and its derivatives, clay hydrated silicates, magnesium aluminum silicates or a mixture thereof. Again, such thickeners are known in the art and available commercially.
  • the fungicidal composition of the present invention may further comprise one or more solid adherents.
  • adherents are known in the art and are available commercially. They include organic adhesives, including tackifiers, such as celluloses or substituted celluloses, natural and synthetic polymers in the form of powders, granules, or lattices, and inorganic adhesives, such as gypsum, silica, or cement.
  • composition according to the invention may also comprise water.
  • compositions, method and use according to the present invention employ the following combinations of components:
  • the synergistic composition consists of: from about 15%to about 50%of boscalid; from about 4%to about 12%of metconazole; from about 5%to about 20%of strobilurin; from about 1%to 50%of surfactant; and from 1%to 80%water by weight of the composition; the strobilurin being one or more of pyraclostrobin, picoxystrobin, azoxystrobin or dimoxystrobin.
  • This preferred synergistic composition can surprisingly achieve an unexpected effect in preventing, controlling and/or treating fungal infestations.
  • compositions may contain, in addition to components (A) , (B) and (C) , one or more herbicides, insecticides, bactericides, acaracides or nematicides, in order to broaden the spectrum of activity.
  • compositions according to the invention are distinguished by the fact that they are especially well tolerated by plants and are environmentally friendly.
  • composition, method and use of the present invention can be used in the agricultural sector and related fields of use for controlling a wide range of fungi.
  • fungal infestations that may be prevented and/or treated include:
  • compositions and techniques of the present invention include:
  • the present invention is particularly advantageous when used to prevent and/or treat infestations of Alternaria spp., Botrytis spp., Puccinia spp., Phoma spp., Mycosphaerella spp., Septoria spp., and Sclerotinia spp., in particular Botrytis, Puccinia recondite, Mycosphaerella graminicola, Septoria tritici, Sclerotinia sclerotiorum, Alternaria cucumerina and Phoma exigua.
  • composition, method and use of the present invention are suitable for the protection of a wide range of plants and crops, including: cereals (wheat, barley, rye, oats, corn, rice, sorghum, triticale and related crops) ; beet (such as sugar beet and fodder beet) ; fruit, such as pomes, stone fruit and soft fruit, such as apples, grapes, pears, plums, peaches, pistachio, almonds, cherries, and berries, for example strawberries, raspberries and blackberries; leguminous plants (drybeans, lentils, peas, soybeans, alfalfa, chickpea, peanut) ; oil plants (rape, mustard, sunflowers, oilseed rape) ; cucurbitaceae (marrows, cucumbers, melons) ; fibre plants (cotton, flax, hemp, jute) ; citrus, such as oranges, lemons, grapefruit and mandarins; vegetables (spinach, lettuce, asparagus
  • the present invention is particularly advantageous when applied to cereals, cucurbitaceae, fruits, leguminous plants, oil plants and vegetables.
  • the present invention is applied to barley, corn, oats, rye, sorghum, wheat, cucurbit, berries, grapes, pistachio, strawberries, tree nuts, alfalfa, beans, chickpea, peanut, peas, soybean, oilseed rape, brassica, carrot, celery and lettuce, particularly, grape, rye, wheat, soybean, cucurbit, oilseed rape, and lettuce.
  • component (A) boscalid is particularly effective in preventing, controlling and/or treating fungal infestations of cereals, cucurbitaceae, fruits, leguminous plants, oil plants and vegetables, their plant parts and/or surroundings.
  • the rates of application of the components (A) , (B) and (C) may vary, for example, according to the degree of control required, type of use, type of crop, the specific active compounds in the combination, type of plants, but is such that the active compounds in the combination in an effective amount to provide the desired action of fungal control.
  • the application rate of the composition or individual components for a given set of conditions can readily be determined by trials.
  • composition of the present invention can be applied at an application rate of between about 0.001 kilograms/hectare (kg/ha) and about 4 kg/ha, based on the total amount of components (A) , (B) and (C) in the composition.
  • An application rate of between about 0.1 kg of components (A) , (B) and (C) per hectare and 2 kg/ha is preferred.
  • the application rate of components (A) and (B) combined is preferably from about 1 g/ha to about 1.5 kg/ha, more preferably from about 100 g/ha to about 800 g/ha, more particularly from about 150 g/ha to about 650 g/ha.
  • the application rate of component (C) is preferably from 1 g/ha to about 1.5 kg/ha, more preferably from about 1 g/ha to about 1 kg/ha, more particularly from about 15 g/ha to about 250 g/ha.
  • compositions of this invention are useful as fungicides, demonstrating synergistic activity for preventing, controlling and/or treating fungal infestations.
  • the compositions can be formulated in the same manner in which fungicides are generally formulated, as discussed above.
  • the components (A) , (B) and (C) may be applied either separately or combined as part of a two-part or three-part system.
  • components (A) , (B) and (C) may be applied in any desired sequence, or in any combination, for example consecutively and/or simultaneously.
  • components (A) , (B) and (C) are applied simultaneously in the present invention, they may be applied as a composition containing components (A) , (B) and (C) , in which case components (A) , (B) and (C) can be obtained from a separate formulation source and mixed together (known as a tank-mix, ready-to-apply, spray broth, or slurry) , optionally with other pesticides, or components (A) , (B) and (C) can be obtained as a single formulation mixture source (known as a pre-mix, concentrate, formulated compound (or product) ) , and optionally mixed together with other pesticides.
  • compositions and formulations can be applied using the methods known in the art. Methods include coating, spraying, dipping, soaking, injection, irrigation, and the like.
  • the active components can be applied to the plants, plant parts and/or their locus where control is desired simultaneously and/or in succession, preferably at short intervals, for example on the same day.
  • the components (A) , (B) and (C) may be applied in any order.
  • the active components may be applied to the plant, one or more parts thereof (such as leaves or seeds) , and/or their locus in any order. Each component may be applied just once or a plurality of times. Preferably, each of the components is applied a plurality of times, in particular from 2 to 5 times.
  • the active fungicidal components may be applied in any order to the target plants, plant material or plant parts, or the locus.
  • the fungicidal components may be applied to the plants in any stage of growth, including the plant propagation material, such as seeds, to the plant locus pre-emergence (that is the period before the emergence of the plants from the soil) , to the plant locus or plants post-emergence (that is after emergence of the plants from the soil) or two or more of these stages.
  • the fungicidal components are applied to plants during both the pre-emergence stage and the post-emergence stage, that is the stage between the emergence of a seedling and the maturity of the plant) .
  • the pre-emergence application includes seed treatment.
  • the fungicidal components are applied directly on the foliage (or leaves) of a plant.
  • Aqueous suspension concentrates were prepared by mixing finely ground active ingredients with auxiliaries including 10%propylene glycol, 0.5%modified polydimethylsiloxane, 3%sodium alkylnaphthalenesulfonate, 1%formaldehyde condensate, polyalkylene glycol ether, 0.1%xanthan gum, 0.1%1, 2-benzisothiazol-3-one and water (balance to 1 L) .
  • auxiliaries including 10%propylene glycol, 0.5%modified polydimethylsiloxane, 3%sodium alkylnaphthalenesulfonate, 1%formaldehyde condensate, polyalkylene glycol ether, 0.1%xanthan gum, 0.1%1, 2-benzisothiazol-3-one and water (balance to 1 L) .
  • composition of an exemplary suspension concentrate (SC) formulation is summarized as follows:
  • Water-dispersible granules were prepared by mixing and milling the active ingredients and auxiliaries including 0.5% (sodium lauryl sulfate, Witco Inc., Greenwich) , 5% (sodium lignosulfonate, Westvaco Corp) , and potassium carbonate (balance to 100%) ) under compressed air, then wetting, extruding and drying to obtain water-dispersible granules.
  • composition of an exemplary water-dispersible granule (WG) formulation is summarized as follows:
  • EC emulsifiable concentrate
  • a water-soluble concentrate (SL) formulation was prepared by mixing the following components:
  • Examples 7 to 10, 16, 22, 28 and 34 are examples of compositions according to the present invention. The remaining examples are presented for comparison purposes.
  • a combination of two or more active compounds has synergistic effect when the efficacy of the combination of two or more active compounds is greater than the sum of the efficacy of each active compound when applied individually.
  • A the percent efficacy of compound A when compound A is employed at a dose of m (gram per hectare, i.e. g/ha) ;
  • E the percent estimated efficacy when compounds A and B are employed together at a dose of m (g/ha) and n (g/ha) , respectively.
  • A the percent efficacy of compound A when compound A is employed at a dose of m (g/ha) ;
  • E the percent estimated efficacy when compounds A and B and C are employed together at a dose of m (g/ha) , n (g/ha) and p (g/ha) , respectively.
  • Young grape plants were treated with the formulations of Examples 1 to 10 above and then sprayed with a conidial suspension of Botrytis. The treated plants were incubated at 20°C and 100%relative atmospheric humidity for 48 hours.
  • Formulations of Examples 11 to 16 were diluted and then sprayed onto the plants. After remaining in a greenhouse at 15°C and 80%relative atmospheric humidity for 15 days, the effectiveness of the treatment in preventing the fungal infestation of the young rye plants was assessed. The results are summarized in Table 3 below.
  • Young wheat plants were sprayed with a conidial suspension of Mycosphaerella graminicola, and incubated at 20°C and 100%relative atmospheric humidity for 48 hours.
  • Formulations of Examples 17 to 22 were diluted and then sprayed on the plants. After remaining in a greenhouse at 15°C and 80%relative atmospheric humidity for 15 days, the effectiveness of the treatment in preventing the fungal infestation of the young wheat plants was assessed. The results are summarized in Table 4 below.
  • Young wheat plants were treated with formulations of Examples 23 to 28 summarised above, sprayed with a conidial suspension of Septoria Tritici) , and incubated at 20°C and 100%relative atmospheric humidity for 48 hours.
  • Young soybean plants were sprayed with a conidial suspension of Sclerotinia sclerotiorum and incubated at 20°C and 100%relative atmospheric humidity for 48 hours. Formulations of Examples 29 to 34 were diluted and then sprayed on the plants.
  • Young cucurbit plants were sprayed with a conidial suspension of Alternaria cucumerina and incubated at 20°C and 100%relative atmospheric humidity for 48 hours. Formulation of Examples 29 to 34 were diluted and then sprayed on the plants.
  • Young oilseed rape plants were treated with formulations of Examples 29 to 34 summarised above and then sprayed with a conidial suspension of Sclerotinia sclerotiorum and incubated at 20°C and 100%relative atmospheric humidity for 48 hours.
  • Young lettuce plants were sprayed with a conidial suspension of Phoma exigua and incubated at 20°C and 100%relative atmospheric humidity for 48 hours. Formulations of Examples 17 to 22 were diluted and then sprayed on the plants.

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Pretreatment Of Seeds And Plants (AREA)

Abstract

L'invention concerne une composition fongicide synergique, la composition comprenant : un composant (A) : boscalide ; un composant (B) : metconazole ; et un composant (C) : au moins un fongicide de type strobilurine choisi parmi la pyraclostrobine, la picoxystrobine, l'azoxystrobine et la dimoxystrobine. L'invention concerne également un procédé de lutte contre les infestations fongiques employant un composant (A) : boscalide ; un composant (B) : metconazole ; et un composant (C) : au moins un fongicide de type strobilurine choisi parmi la pyraclostrobine, la picoxystrobine, l'azoxystrobine et la dimoxystrobine.
PCT/CN2018/083143 2017-05-04 2018-04-16 Composition fongicide et son utilisation WO2018201881A1 (fr)

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CN110505806A (zh) 2019-11-26
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GB2562082B (en) 2021-10-27
AR111378A1 (es) 2019-07-03
GB2562082A (en) 2018-11-07

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