WO2018199709A3 - Aimp1을 포함하는 전신 홍반성 루프스 진단용 바이오마커 조성물 및 이를 이용한 전신 홍반성 루프스 진단 방법 - Google Patents

Aimp1을 포함하는 전신 홍반성 루프스 진단용 바이오마커 조성물 및 이를 이용한 전신 홍반성 루프스 진단 방법 Download PDF

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Publication number
WO2018199709A3
WO2018199709A3 PCT/KR2018/005001 KR2018005001W WO2018199709A3 WO 2018199709 A3 WO2018199709 A3 WO 2018199709A3 KR 2018005001 W KR2018005001 W KR 2018005001W WO 2018199709 A3 WO2018199709 A3 WO 2018199709A3
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WO
WIPO (PCT)
Prior art keywords
lupus erythematosus
systemic lupus
aimp1
diagnosis
sle
Prior art date
Application number
PCT/KR2018/005001
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English (en)
French (fr)
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WO2018199709A9 (ko
WO2018199709A2 (ko
Inventor
박상규
이상원
Original Assignee
아주대학교산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아주대학교산학협력단 filed Critical 아주대학교산학협력단
Priority to JP2019558482A priority Critical patent/JP6835983B2/ja
Priority to US16/608,931 priority patent/US20200191784A1/en
Publication of WO2018199709A2 publication Critical patent/WO2018199709A2/ko
Publication of WO2018199709A3 publication Critical patent/WO2018199709A3/ko
Publication of WO2018199709A9 publication Critical patent/WO2018199709A9/ko

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/104—Lupus erythematosus [SLE]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

본 발명은 AIMP1을 유효성분으로 포함하는 SLE 진단용 바이오마커 조성물 및 이를 이용한 SLE 진단 방법에 대한 것으로, 상세하게는 AIMP1을 포함하는 SLE 진단용 바이오마커 조성물, 이를 이용한 SLE 진단 키트 및 SLE 진단 방법을 제공한다. 또한, 본 발명은 AIMP1을 유효성분으로 포함하는 SLE 예후 예측용 바이오마커 조성물 및 이를 이용한 SLE 예후 예측 키트 및 SLE 예후 예측 방법을 제공한다. 따라서, 본 발명의 AIMP1은 SLE 진단 및 예후 예측에 유용하게 활용될 수 있다.
PCT/KR2018/005001 2017-04-28 2018-04-30 Aimp1을 포함하는 전신 홍반성 루프스 진단용 바이오마커 조성물 및 이를 이용한 전신 홍반성 루프스 진단 방법 WO2018199709A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2019558482A JP6835983B2 (ja) 2017-04-28 2018-04-30 Ａｉｍｐ１を含む全身性紅斑性狼瘡診断用バイオマーカー組成物及びそれを用いた全身性紅斑性狼瘡診断方法
US16/608,931 US20200191784A1 (en) 2017-04-28 2018-04-30 Biomarker composition for diagnosis of systemic lupus erythematosus comprising aimp1 and method for diagnosing systemic lupus erythematosus using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0055247 2017-04-28
KR1020170055247A KR20180121057A (ko) 2017-04-28 2017-04-28 Aimp1을 포함하는 전신 홍반성 루프스 진단용 바이오마커 조성물 및 이를 이용한 전신 홍반성 루프스 진단 방법

Publications (3)

Publication Number Publication Date
WO2018199709A2 WO2018199709A2 (ko) 2018-11-01
WO2018199709A3 true WO2018199709A3 (ko) 2019-03-28
WO2018199709A9 WO2018199709A9 (ko) 2019-05-02

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PCT/KR2018/005001 WO2018199709A2 (ko) 2017-04-28 2018-04-30 Aimp1을 포함하는 전신 홍반성 루프스 진단용 바이오마커 조성물 및 이를 이용한 전신 홍반성 루프스 진단 방법

Country Status (4)

Country Link
US (1) US20200191784A1 (ko)
JP (1) JP6835983B2 (ko)
KR (1) KR20180121057A (ko)
WO (1) WO2018199709A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110687285B (zh) * 2019-10-29 2023-03-21 安徽医科大学 诊断试剂盒及mak16在制备系统性红斑狼疮早期诊断试剂中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100005116A (ko) * 2007-04-27 2010-01-13 주식회사 이매진 면역 조절제 스크리닝 방법
KR101067817B1 (ko) * 2008-10-10 2011-09-27 서울대학교산학협력단 Ａｉｍｐ1 폴리펩티드에 대한 항체를 포함하는 관절염 진단용 조성물
KR20150078472A (ko) * 2013-12-30 2015-07-08 재단법인 의약바이오컨버젼스연구단 항 AIMP1/p43 모노클로날 항체 및 이의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08233822A (ja) * 1995-12-13 1996-09-13 Nippon Dpc Corp Ｓｌｅ血清などの体液中における抗二本鎖ｄｎａ抗体の検出プロ−ブ
AU2009305575A1 (en) * 2008-10-16 2010-04-22 Cypress Bioscience, Inc. Method for diagnosis and monitoring of disease activity and response to treatment in systemic lupus erythematosus (SLE) and other autoimmune diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100005116A (ko) * 2007-04-27 2010-01-13 주식회사 이매진 면역 조절제 스크리닝 방법
KR101067817B1 (ko) * 2008-10-10 2011-09-27 서울대학교산학협력단 Ａｉｍｐ1 폴리펩티드에 대한 항체를 포함하는 관절염 진단용 조성물
KR20150078472A (ko) * 2013-12-30 2015-07-08 재단법인 의약바이오컨버젼스연구단 항 AIMP1/p43 모노클로날 항체 및 이의 용도

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AHN, SS ET AL.: "Serum Aminoacyl-tRNA Synthetase-interacting Multifunctional Protein-1 (AIMPI), a Novel Disease Activity Predictive Biomarker of Systemic Lupus Erythematosus", CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol. 36, no. 4, 15 January 2018 (2018-01-15), pages 533 - 539 *
HAN, JUNG MIN ET AL.: "Aminoacyl-tRNA Synthetase-interacting Multifunctional Protein 1/p43 Controls Endoplasmic Reticulum Retention of Heat Shock Protein gp96: Its Pathological Implications in Lupus-like Autoimmune Diseases", THE AMERICAN JOURNAL OF PATHOLOGY, vol. 170, no. 6, June 2007 (2007-06-01), pages 2042 - 2054, XP008157385, DOI: doi:10.2353/ajpath.2007.061266 *
KIM, MYUN SOO ET AL.: "Aminoacyl tRNA Synthetase-interacting Multifunctional Protein 1 Acts as a Novel B Cell -activating Factor in Vitro and in Vivo", THE JOURNAL OF IMMUNOLOGY, vol. 194, no. 10, 2015, pages 4729 - 4736, XP055586572, DOI: 10.4049/jimmunol.1401352 *

Also Published As

Publication number Publication date
WO2018199709A9 (ko) 2019-05-02
KR20180121057A (ko) 2018-11-07
US20200191784A1 (en) 2020-06-18
WO2018199709A2 (ko) 2018-11-01
JP2020519861A (ja) 2020-07-02
JP6835983B2 (ja) 2021-02-24

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