WO2018199266A1

WO2018199266A1 - Flow path switching mechanism, material supply unit, material container, holder of flow path switching mechanism and flow path switching device

Info

Publication number: WO2018199266A1
Application number: PCT/JP2018/017086
Authority: WO
Inventors: 圭市平野
Original assignee: 日本メジフィジックス株式会社; エヌ・エム・ピイビジネスサポート株式会社
Priority date: 2017-04-28
Filing date: 2018-04-26
Publication date: 2018-11-01
Also published as: JP2019147835A; TW201843406A

Abstract

A flow path switching mechanism is configured of a first member (10) in which one or a plurality of first partial flow paths (12a, 12b, 12d) are formed, and a second member (20) which is combined with the first member (10) in a movable state and has a plurality of or one second partial flow path (22a, 22b, 22c). With this configuration, by combining a driving force receiving convex portion (27), which receives the driving force for moving the second member (20) in both directions of the x axis, the first member (10) and the second member (20), one of the first partial flow paths (12a, 12b, 12d) and one of the second partial flow paths (22a, 22b, 22c) are communicated with each other to form a flow path, and the combination of the one of the first partial flow paths (12a, 12b, 12d) and the one of the second partial flow paths (22a, 22b, 22c), which communicate with each other, is changed by moving the second member (20) in both directions of the x axis, while maintaining the combination of the first member (10) and the second member (20), thereby switching the flow path to another flow path.

Description

Channel switching mechanism, material supply unit, material container, channel switching mechanism holder and channel switching device

The present invention relates to a flow path switching mechanism that switches a flow path of a material of a fluid used for chemical processing, a material supply unit, a holder of the flow path switching mechanism, and a flow path switching device.

In an apparatus for synthesizing a drug by chemical treatment, there is a case where one material is used in a plurality of synthesizing steps by switching a flow path of a material or the like used for synthesizing the drug.
As a fluid control mechanism for switching a known flow path, for example, there are those described in Patent Document 1 and Patent Document 2.
Patent Document 1 describes a drug manufacturing system. The pharmaceutical production system described in Patent Document 1 switches the flow path of the three-way cock by rotating the three-way cock holder while the three-way cock is mounted by the action of a motor. Moreover, the manufacturing apparatus of the organic compound of patent document 2 has the structure which mounts a three-way active holder in steps.

JP 2010-270068 A JP 2014-151571 A

In the three-way cock described in Patent Document 1 and Patent Document 2 described above, three flow paths are always secured, and opening and closing them secures other flow paths even during use of one flow path. Space will be required. However, there is a field in which drug synthesis is performed using a very small amount of material, for example, synthesis of radiopharmaceuticals. For the synthesis of a radiopharmaceutical, a very small amount of liquid material such as 100 μl is used. When such a flow path through which the liquid material flows is switched using a known three-way stopcock, the amount of the liquid material remaining in the vacant space increases, and the ratio of the remaining amount to the usage amount increases.
The present invention has been made in view of the above points, and has a switching mechanism with a small amount of remaining material, a material supply unit using this switching mechanism, a material container, a holder for a channel switching mechanism, a channel switching device, and A material container is provided.

One aspect of the flow path switching mechanism of the present invention is a flow path switching mechanism that switches a flow path for circulating a material used for chemical treatment, and a first member in which one or a plurality of first partial flow paths are formed; A second member having a plurality of or one second partial flow path in combination with the first member in a movable state, and a driving force receiving unit that receives a driving force for moving the second member in both directions of one axis. And the first member and the second member are combined so that the first partial channel and the second partial channel communicate to form a channel, and the first member And the second member moving in both directions of the one axis while maintaining the combination of the second member and the second member, the combination of the first partial flow path and the second partial flow path communicating with each other is changed. The flow path is switched to another flow path.

One aspect of the material supply unit of the present invention includes a material container having a bottom surface that is broken by the flow path convex portion of the flow path switching mechanism.
The material container of the present invention is a bottomed material container for storing a material used for chemical treatment, and a container main body for storing the material, and a bottom surface for sealing the inside of the container main body. The bottom surface includes at least a fragile portion that can be broken.

One aspect of the holder of the flow path switching mechanism of the present invention is the insertion groove into which the flow path switching mechanism is inserted from at least one direction that holds the flow path switching mechanism and intersects the row direction. The flow path switching mechanisms inserted into the grooves alternately have locking projections that are locked by moving in the row direction.
One aspect of the flow path switching device of the present invention includes a drive unit that applies a driving force to the drive force receiving unit to move the second member of the flow path switching mechanism in both directions of one axis, and the flow path switching unit. A flow path switching mechanism holding receiving portion for holding the first member of the mechanism, and the flow path switching mechanism holding receiving portion is configured such that the first member is moved while the second member is stationary and moved by the driving portion. Keep it from moving.

The present invention can provide a switching mechanism with a small amount of remaining material in the flow path, a material supply unit using the switching mechanism, a material container, a holder of the flow path switching mechanism, and a flow path switching device.

It is a figure for demonstrating the flow-path switching mechanism of 1st embodiment. It is a top view, a front view, and a side view of the first member shown in FIG. It is a top view, a front view, and a side view of the second member shown in FIG. It is a figure for demonstrating switching of the flow path of 1st embodiment of this invention. It is a figure for illustrating the member which transmits the driving force of the side which pushes and pulls the driving force acceptance convex part of a first embodiment. It is a perspective view of the flow-path switching mechanism of 2nd embodiment of this invention. It is a disassembled perspective view of the flow-path switching mechanism shown in FIG. It is a perspective view of the 1st member of the flow-path switching mechanism shown in FIG. FIG. 7 is a top view, a front view, and a cross-sectional view of the flow path switching mechanism shown in FIG. 6. It is a perspective view of the material supply unit of 2nd embodiment of this invention. It is a perspective view of the material container shown in FIG. It is sectional drawing which expands and shows a part of container main body shown in FIG. It is an enlarged view of the bottom face shown to FIG. It is a figure for demonstrating the process in which the bottom face shown to FIG. It is a figure for demonstrating the holder of 2nd embodiment of this invention. It is a perspective view for demonstrating the material supply unit of 3rd embodiment of this invention. It is a material container shown in FIG. 16, Comprising: It is a perspective view which shows the state which the cover part closed the opening part. It is the material container shown in FIG. 16, Comprising: It is a perspective view which shows the state in which the cover part opened the opening part. It is the top view which looked at the material container shown in FIG. 18 from the direction of arrow IV. It is the bottom view which looked at the material container shown in FIG. It is sectional drawing which follows the arrow line VI of the material container shown in FIG. It is an enlarged view of the range enclosed with the broken line VII of the container main body shown in FIG. It is the enlarged view which looked at the bottom face shown in FIG. 22 from the direction of the arrow line V in FIG. It is a figure for demonstrating the lid fixing mechanism of three embodiment of this invention. It is a perspective view of the flow-path switching mechanism of 4th embodiment of this invention. It is a disassembled perspective view of the flow-path switching mechanism shown in FIG. It is a figure which shows the trace amount sampling system using the flow-path switching mechanism of 4th embodiment of this invention. It is a figure for demonstrating the fluid which flows through a flow-path switching mechanism in the trace amount sampling system shown in FIG. (A) is a perspective view of the 1st member of 5th embodiment, (b) is a perspective view of the 2nd member. It is the figure which showed the flow-path switching system containing the flow-path switching apparatus of 6th embodiment of this invention. It is a figure for demonstrating the inside of the flow-path switching mechanism holding | maintenance unit shown in FIG. It is a disassembled perspective view for demonstrating the flow-path switching mechanism attached to the flow-path switching mechanism holding | maintenance unit shown in FIG. It is a figure for demonstrating the flow path of the 1st member of FIG. It is a schematic diagram for demonstrating the separate drive part shown in FIG. (A), (b), (c) is the perspective view of the flow-path switching mechanism holding | maintenance receiving part shown in FIG. 34, and a flow-path switching mechanism.

Hereinafter, a first embodiment to a fifth embodiment of the present invention will be described with reference to the drawings. In all the drawings, the same constituent elements are denoted by the same reference numerals, and redundant description is omitted as appropriate. In the embodiment described below, in the flow path switching mechanism, the material supply unit, the holder, and the flow path switching apparatus, the flow path switching mechanism has a side provided with the holder engaging portion 15 (FIG. 1). Side up. Such a vertical direction is determined regardless of the direction of gravity.
1 to 26 shown in the embodiments described below are the configurations of the flow path switching mechanism, the material supply unit using the flow path switching mechanism, the holder of the flow path switching mechanism, and the flow path switching device. The purpose is to explain the arrangement relationship, and the length, thickness, width, and the like of each member are not necessarily shown accurately.

[First embodiment]
(Flow path switching mechanism)
Hereinafter, the flow path switching mechanism of the first embodiment of the present invention will be described. The flow path switching mechanism according to the first embodiment is a mechanism for switching a flow path through which a material used for chemical processing is circulated. In the first embodiment, the “chemical treatment” is a synthetic treatment using a known organic chemical reaction, as well as reaction, conversion, ionization, separation (purification), hydrolysis, and recovery of individual substances performed for this treatment. And processing such as extraction.
Fig.1 (a), FIG.1 (b), and FIG.1 (c) are the figures for demonstrating the flow-path switching mechanism of 1st embodiment. Fig.1 (a) is a perspective view for demonstrating the flow-path switching mechanism of 1st embodiment, and is comprised combining. FIG. 1B shows the first member 10, and FIG. 1C shows the second member 20.

As shown in FIG. 1B, the first member 10 includes a main body 14. The main body 14 is a frame having a predetermined thickness. In FIGS. 1A to 1C, the surface of the frame that faces the z direction of the x, y, and z coordinates shown in the drawing is the upper surface. A surface directed in the 11a, −z direction is defined as a lower surface 11c. In this specification, only the + x direction, the + y direction, and the + z direction are shown among the x, y, and z coordinate axes, but the directions opposite to the directions indicated by the arrow lines of the respective axes are − It indicates the x direction, -y direction, and -z direction.
A holder engaging portion 15 is provided on the main body 14 of the first member 10. In the first embodiment, the surfaces in the y direction and the −y direction are the side surfaces. Furthermore, in the first embodiment, the surface in the x direction is the back surface 11f, the surface in the -x direction is the front surface 11e, and the hollow portion 16 is formed between the back surface 11f and the front surface 11e. For this reason, each of the back surface 11f and the front surface 11e has a frame shape. The upper surface 11a, the lower surface 11c, the side surfaces 11b, 11d, and the back surface 11f are all outer surfaces, and the surface corresponding to the rear surface of the outer surface is referred to as “inner surface”.

The first member 10 described above has flow path convex portions having a convex shape around the end portions on the side toward the outside of the first

partial flow paths

12a, 12b, and 12d. In 1st embodiment, the flow-path

convex part

13a, 13b, 13d is provided in the upper surface 11a of the main body 14, and the side surfaces 11b, 11d, respectively.
The flow path

convex portions

13 a, 13 b, and 13 d have a function of connecting a container that stores a liquid containing a material to the flow path switching mechanism 1. Further, the flow path

convex portions

13 a, 13 b, and 13 d have a function of connecting a tube (not shown) to the flow path switching mechanism 1. According to such a configuration, it is possible to introduce the liquid including the material or the like from the tube or the gaseous fluid that defines the moving direction of the material into the flow path switching mechanism 1 and flow out of the flow path switching mechanism 1.
Here, “material” includes substances, chemicals (reagents), catalysts, water, and the like used for the synthesis of a drug. The material or the like is a term including a gas such as an inert gas for promoting the flow of the material in addition to such a material. When the flow path switching mechanism 1 is used for the synthesis of a radioactive compound or a radiopharmaceutical (including a polymer or an antibody labeled with a radionuclide, hereinafter collectively referred to as “radiopharmaceutical etc.”), the material includes Synthetic materials such as these radiopharmaceuticals are accommodated. Examples of synthetic materials such as radiopharmaceuticals include substances (labeling precursors, etc.), chemicals (reagents), catalysts, water and the like used for the synthesis of radiopharmaceuticals.

The first member 10 is formed with one or a plurality of first partial flow paths. In the first embodiment, three first

partial flow paths

12 a, 12 b, and 12 d are formed in the first member 10. The first partial channel 12a is a channel having an opening 12ab on the inner surface of the upper surface 11a and an opening 12aa at the tip of the channel convex portion 13a. The first partial channel 12b is a channel having an opening 12bb on the inner surface of the side surface 11b and an opening 12ba at the tip of the channel protrusion 13b. The first partial channel 12d is a channel having an opening 12da on the inner surface of the side surface 11d and an opening 12db at the tip of the channel convex portion 13d.

The second member 20 is combined with the first member 10 so as to be movable in both the x-axis directions (x direction and −x direction) with respect to the first member 10, and has a plurality of or one second partial flow path. is doing. That is, the second member 20 faces the upper surface 21a in the z direction, the lower surface 21c in the -z direction, the side surface 21b in the -y direction, the side surface 21d in the y direction, the back surface 21f in the x direction, and the -x direction. It has a front surface 21e. Such a second member 20 has a main body 24 having a rectangular parallelepiped appearance. The second member 20 has a small-diameter second partial flow channel communicating with the outside inside the main body 24.

In the first embodiment, the second member 20 has three second

partial flow paths

22a, 22b, and 22c. The second partial flow path 22a is a flow path having an opening 22aa on the upper surface 21a and an opening 22ab on the side surface 21d. Such a second partial flow path 22a has a shape in which the “L” shape is reversed left and right in a front view. The second partial channel 22b is a channel having an opening 21ba on the side surface 21b and an opening 22cb on the side surface 21d. Such a second partial flow path 22b has a linear shape along the y-axis in a front view. The second partial flow path 22c is a flow path having an opening 22ca on the upper surface 21a and an opening 22cb on the side surface 21b. Such a second partial flow path 22c has an “L” shape in a front view.

In addition, the second member 20 of the first embodiment includes a driving force receiving portion that receives a driving force that moves the second member 20 in both directions of the x-axis. The driving force receiving portion of the first embodiment is a driving force receiving convex portion 27 provided on the front surface 21e and having a convex shape. In the first embodiment, one axis is the x axis in the figure, and the driving force receiving convex portion 27 is a member that moves the second member 20 in the x direction and the −x direction. The configuration of the driving force receiving convex portion 27 will be described later in detail.

When the first member 10 and the second member 20 are combined, the first partial flow path and the second partial flow path communicate with each other to form a flow path. Here, the flow path is a path through which the fluid that has entered one flow path switching mechanism 1 flows out of the flow path switching mechanism 1, and the first or second partial flow path is such a flow. Refers to the road part. The combination of the first member 10 and the second member 20 is performed by inserting the second member 20 through the hollow portion 16 of the first member 10. In the first embodiment, when the second member 20 is inserted through the hollow portion 16 of the first member 10, the inner surface of the first member 10 and the upper surface 21a, side surfaces 21b, 21d, and the lower surface 21c of the second member 20 are moderate. The size and material of the first member 10 and the second member 20 are designed so that the second member 20 moves smoothly in the hollow portion 16 and stably stops while contacting with a certain amount of friction.
And in the flow-path switching mechanism 1 of 1st embodiment, the 2nd member 20 moves to a x-axis direction, maintaining the combination of the 1st member 10 and the 2nd member 20, and the 1st partial flow path connected And the combination of the second partial flow path is changed and the flow path is switched to another flow path. Note that “switching the flow path” includes changing the path between the start end and the end, in addition to changing the start end and end of the flow path.

Hereinafter, the above configuration will be described in detail.
(Switching the flow path)
2, 3 and 4 are diagrams for explaining the flow path switching of the first embodiment. 2A is a top view of the first member 10, FIG. 2B is a front view of the first member 10, and FIG. 2C is a side view of the first member 10. 3A is a top view of the second member 20, FIG. 3B is a front view of the second member 20, and FIG. 3C is a side view of the second member 20. FIG. 4A is a top view of the flow path switching mechanism 1 when the second member 20 is at the position P1. 4B is a top view of the flow path switching mechanism 1 when the second member 20 is at the position P2, and FIG. 4C is a flow path switching mechanism 1 when the second member 20 is at the position P3. FIG. In the first embodiment, the position P1, the position P2, and the position P3 are all expressed as the position of the front surface 21e with the front surface 11e of the first member 10 as the reference position P0. As is clear from FIGS. 4A, 4B, and 4C, the second member 20 is pushed into the first member 10 in the order of position P1, position P2, and position P3. Has moved to.

As shown in FIG. 2 (a), the first member 10 is formed with a first partial flow path 12 b and a first partial flow path 12 d on a straight line, and both opening portions 12 bb and 12 da are connected to the hollow portion 16. ing. At this time, when the second member 20 shown in FIG. 3 (a) moves to the position P1 shown in FIG. 4 (a), the opening 12da (see FIG. 2 (a)) of the first partial flow path 12d and the second partial flow. The opening 22ab of the channel 22a is connected, and the opening 22aa of the second partial channel 22a and the opening 12ab (see FIG. 2C) of the first partial channel 12a are connected to form a channel. . In the first embodiment, such a flow path is hereinafter referred to as “flow path 12d-22a-12a”. In the

flow paths

12d, 22a, and 12a, the opening 12db communicates with the opening 12aa, and a fluid can flow between them.

When the second member 20 moves to the position P2 shown in FIG. 4B, the opening 12da (see FIG. 2A) of the first partial flow path 12d and the opening 22bb of the second partial flow path 22b are connected. The openings 22ba of the second partial channel 22b and the openings 12bb (see FIG. 2C) of the first partial channel 12b are connected to form a channel. Hereinafter, this channel is referred to as “channel 12d-22b-12b”. In the flow path 12d-22b-12b, the opening 12da communicates with the opening 12ba, and a fluid can flow between them.
Further, when the second member 20 moves to the position P3 shown in FIG. 4C, the opening 12bb (see FIG. 2C) of the first partial flow path 12b and the opening 22cb of the second partial flow path 22c (see FIG. 3 (c)) is connected, and the opening 22aa of the second partial flow path 22b and the opening 12ab (see FIG. 2 (c)) of the first partial flow path 12a are connected to form a flow path. . Such a channel is hereinafter referred to as “channel 12b-22c-12a”. In the flow path 12b-22c-12a, the opening 12ba communicates with the opening 12aa, and a fluid can flow between them.

As described above, in the flow path switching mechanism 1 of the first embodiment, the second partial flow path is orthogonal to one axis (x-axis), and the first partial flow path is in communication with the second partial flow path x A flow path is formed along at least one of two axes (y-axis and z-axis) orthogonal to the axis.
Specifically, the second

partial flow paths

22a, 22b, and 22c are all orthogonal to the x axis that is one axis. Here, the orthogonal includes not only the intersection of the coordinate axes in FIG. 1 on the xy plane but also the intersection on the xz plane.
For example, the second partial flow path 22a is orthogonal to the x axis and the xy plane from the opening 22ab to a portion where the angle changes by 90 degrees, and from this portion to the opening 22aa on the x axis and the xz plane. Orthogonal. In the second partial flow path 22b, the entire opening 22ba to 22bb is orthogonal to the x axis on the xy plane. Furthermore, the second partial flow path 22c is orthogonal to the x-axis and the xy plane from the opening 22cb to a portion where the angle changes by 90 degrees, and from this portion to the opening 22ca on the x-axis and the xz plane. Orthogonal.

According to such a configuration of the first embodiment, the residual amount of the liquid material in the portion where the angle of the flow path changes is reduced, and the liquid material is quickly removed from the inner surface of the flow path by an inert gas or the like. be able to.
However, the above configuration is an example of the first embodiment, and the first embodiment is not limited to such a configuration. In the first embodiment, for example, the first partial flow path and the second partial flow path may be bent with an angle other than 90 degrees. Furthermore, the first partial flow path and the second partial flow path may be paths that communicate obliquely without bending between the openings at both ends.

(Driving force receiving convex part)
The driving force receiving convex portion 27 of the first embodiment described above is a plate member 10 including a peripheral surface having a curved surface portion 27a and a flat surface portion 27b. As illustrated in FIGS. 3A to 3C, the driving force receiving convex portion 27 is fixed to the front surface 21 e of the second member 20 via the support portion 23. The driving force receiving convex portion 27 of the first embodiment engages with a member that transmits driving force such as a motor, and pushes or pulls the second member 20 in the x-axis direction by pushing or pulling the second member 20. Directional driving force is accepted.
FIG. 5A and FIG. 5B are diagrams for illustrating a member that transmits the driving force on the side that pushes and pulls the driving force receiving convex portion 27 of the first embodiment. The

members

51 and 53 for transmitting the driving force shown in FIGS. 5A and 5B are both engaged with the driving force receiving convex portion 27, and push and pull the driving force receiving convex portion 27 along the x-axis. It is the structure which transmits the driving force to do. The

members

51 and 53 are different in that the member 51 is integrally formed while the member 53 is formed of two parts. In the first embodiment, an actuator such as a motor, a solenoid, or a cylinder may be used as a driving source of the driving force, or the second member 20 may be manually moved using the operator's muscle as a chemical actuator. Good.

The member 51 shown in FIG. 5A includes a circumferential surface 51d that is a curved surface, side surfaces 51g and 51f that are provided perpendicular to the circumferential surface 51d, and a surface 51e that is perpendicular to both the side surfaces 51g and 51f. . The member 51 is formed with an engaging portion 51a that engages with the driving force receiving convex portion 27, and the member 51 accommodates the driving force receiving convex portion 27 in the direction of the arrow A in 51a. The driving force receiving convex portion 27 is designed such that the length in the z-axis direction corresponds to the distance between the upper end 51b and the lower end 51c of the engaging portion 51a, and is fitted to the engaging portion 51a. With such a configuration, the driving force receiving convex portion 27 is not detached from the engaging portion 51a even if a force along the x-axis is applied after being fitted to the engaging portion 51a.
5B includes a circumferential surface 53d including three planes, side surfaces 53g and 53f provided perpendicular to the circumferential surface 53d, and a surface 53e perpendicular to both the side surfaces 53g and 53f. I have. The member 53 is formed with an engaging portion 53a that engages with the driving force receiving convex portion 27, and the member 53 accommodates the driving force receiving convex portion 27 in the direction of the arrow A in 53a. The driving force receiving convex portion 27 is designed such that the length in the z-axis direction corresponds to the distance between the upper end 53b and the lower end 53c of the engaging portion 53a, and is fitted into the engaging portion 53a. With such a configuration, the driving force receiving convex portion 27 does not come off the engaging portion 53a even if a force along the x-axis is applied after being fitted to the engaging portion 53a.

However, the driving force receiving portion of the first embodiment is not limited to the one having a convex shape as described above. If the driving force receiving portion engages with a member that transmits the driving force, it depends on the shape of this member. It may have a concave shape or any other shape. At this time, the

members

51 and 53 may have any shape corresponding to the driving force receiving portion.
Furthermore, 1st embodiment is not limited to what a driving force reception part receives the driving force of a push pull. For example, the driving force in the pressing direction may be alternately applied to the front surface 21e and the back surface 21f of the second member 20, and the second member 20 may be moved along the x axis. In such a case, the driving force receiving portions are the front surface 21e and the back surface 21f. That is, the driving force receiving portion may be a flat surface.

The flow path switching mechanism 1 described above is entirely formed by integral molding of resin. Any resin can be used as the material for the flow path switching mechanism 1 as long as it satisfies the conditions required for the flow path switching mechanism 1, such as thermoplasticity, rigidity, elasticity, transparency, solvent resistance, and cost. It may be. Examples of the resin that satisfies such conditions include polyethylene terephthalate (Poly Ethylene Terephthalate), thermopolyolefin (Thermo Poly Olefin), polypropylene (Poly Propylene), and the like.
However, the first embodiment is not limited to forming the flow path switching mechanism 1 by integral molding with resin. The flow path switching mechanism 1 may use a material other than a resin such as metal for all or a part of the flow path switching mechanism 1.

The flow path switching mechanism 1 of the first embodiment described above can switch the flow path of the fluid by moving the second member 20 along one axis. For this reason, the space required for the switching operation of the flow path can be made smaller than the configuration in which the flow path is switched by rotating the parts as in, for example, a rotary type three-way cock. Moreover, the flow path switching mechanism 1 of the first embodiment that forms a flow path as necessary is more advantageous in reducing dead space in parts than a three-way stopcock or the like in which three flow paths are always formed. . Furthermore, since the flow path switching mechanism 1 of the first embodiment forms only necessary flow paths when necessary, the component configuration is simplified rather than selectively opening and closing a plurality of flow paths by other members. It is advantageous to do. For this reason, it is possible to provide a flow path switching mechanism suitable for a process using a small amount of material by reducing the diameter of the flow path from a known configuration and reducing the remaining amount of material.

Next, the flow path switching mechanism, material supply unit, and holder of the second embodiment will be described.
[Second Embodiment]
(Flow path switching mechanism)
FIG. 6, FIG. 7, FIG. 8, FIG. 14 (a), FIG. 14 (b) and FIG. 14 (c) are diagrams for explaining the flow path switching mechanism 3 of the second embodiment. 6 is a perspective view of the flow path switching mechanism 3, and FIG. 7 is an exploded perspective view of the first member 60 and the second member 20 of FIG. 8 is a view for explaining the flow path of the first member 60 of FIG. 7, FIG. 14 (a) is a top view of the first member 60, and FIG. 14 (b) is a front view of the first member 60. FIG. 14C is a cross-sectional view of the first member 60 taken along 9c-9c.

As shown in FIGS. 6 to 8, in the flow path switching mechanism 3, a plurality of second members 20 are arranged in one row direction (y-axis direction shown in the drawing) and combined with the first member 60. . At least one of the flow paths of the flow path switching mechanism 3 is formed by communicating the second partial flow paths of the plurality of second members 20 via the first partial flow paths.
In the second embodiment, the y-axis shown in FIG. The first member 60 has an upper surface 61a, side surfaces 61b and 61d, a lower surface 61c, a front surface 61e, and a back surface 61f. A hollow portion 66 (FIGS. 8 and 9) is formed in the first member 60, and the front surface 61 e and the back surface 61 f have a frame shape corresponding to the plurality of hollow portions 66. Channel convex portions 63a are formed on the upper surface 61a, and channel

convex portions

63b and 63d are formed on the side surfaces 61b and 61d, respectively. Further, a holder engaging portion 65 is formed on the lower surface 61c.

As shown in FIGS. 6 to 9, the first member 60 has a main body 64. The main body 64 includes first

partial flow paths

62a, 62b, 62c, 62d, 62e, 62f, 62g, 63h, 62i, 62j, 62k, 62o, 62p, 62q, 62r, 62s, 62t, 62u, 62v, 62w, 62x, 62y is formed, and the first partial flow paths 62a to 62y communicate with the hollow portion 66, respectively. The hollow portion 66 is formed with openings 62ab to 62jb, openings (not shown) opened to face the openings 62ab to 62jb, and openings (not shown) of the first partial flow paths 62o to 62y. (See FIG. 8).
Moreover, in 2nd embodiment, the 2nd member 20 is penetrated by the hollow part 66 similarly to 1st embodiment, and the 1st partial flow path and the 2nd partial flow path of the 2nd member 20 inside the hollow part 66 are A flow path is formed in communication. In such a flow path switching mechanism 3, the second partial flow paths of the plurality of second members 20 can be communicated via the first partial flow paths to form a flow path.

For example, in FIGS. 7 and 8, the second member 20 (referred to as “second member 20 </ b> A” for convenience of explanation) inserted between the first partial channel 62 b and the first partial channel 62 c is shown in FIG. 4. Move to position P1. Further, the second member 20 (referred to as “second member 20B”) inserted between the first partial channel 62c and the first partial channel 62d is moved to the position P2 shown in FIG. The second member 20 (referred to as “second member 20C”) inserted between 62d and the first partial flow path 62e is moved to the position P3 shown in FIG. At this time, the flow path switching mechanism 3 is formed with flow paths 62p-22a-62c-22b-62d-12c-62r. When a liquid is passed through this flow path, the fluid that has flowed into the second member 20A from the first partial flow path 62p passes through the second partial flow path 22b of the second member 20B and passes through the second partial flow path 22c of the second member 20C. It can flow out to the outside through a partial flow path 62r.
Further, for example, when all the second members 20 of the flow path switching mechanism 3 are moved to the position P2 shown in FIG. 4, the flow path switching mechanism 3 includes the first partial flow path 62a to the first partial flow path 62y. A flow path communicating in a straight line is formed. Furthermore, if the flow path convex portions 63a are connected to each other, the fluid can be circulated and stirred in the flow path switching mechanism 3.
From the above, the second embodiment can arbitrarily connect the second

partial flow paths

22a, 22b, and 22c between the plurality of second members 20. Such a second embodiment has a higher degree of freedom in designing the flow path than the first embodiment, and can arbitrarily control the movement of the fluid in the synthesizer.

(Material supply unit)
FIG. 10 is a diagram for explaining the material supply unit 100 of the second embodiment. The material supply unit 100 includes the flow path switching mechanism 3 of the second embodiment and the material container 80. The material container 80 includes a material container 80 having a bottom surface 83 (see FIGS. 11 to 13) that is broken by the flow path convex portion 63a (see FIGS. 6 to 9) of the flow path switching mechanism 3. 90 shown in FIG. 10 has its bottom surface 83 inserted into the flow path convex portion 63a of the flow path switching mechanism 3, and the internal material is supplied to the flow path switching mechanism 3 from the flow path convex portion 63a.
FIG. 11 is a perspective view of the material container 80 shown in FIG. FIG. 12 is a cross-sectional view taken along arrow XII. FIG. 13 is an enlarged view of the bottom surface 83 shown in FIGS.
The material container 80 includes a container main body 90 that is a container main body that is long in the vertical direction. The container body 90 connects the cylindrical portion 87 having a cylindrical shape with a constant outer diameter and inner diameter, a cylindrical portion 89 having a constant outer diameter and inner diameter smaller than the cylindrical portion 87, and the cylindrical portion 87 and the cylindrical portion 89. And a tapered portion 88 having an inclined surface. A bottom surface 83 is provided between the boundary between the tapered portion 88 and the cylindrical portion 89 and the lower end portion 79 of the cylindrical portion 89.

In addition, the material container 80 includes a lid 5 at the upper end. An abutting portion 86 is provided at the upper end of the cylindrical portion 87 so as to abut against the lid plate 81 of the lid portion 5 and close the container main body 90. Further, the lid 5 is bent so that the

connection pieces

84 and 82 connecting the lid 5 and the cylinder 87 and the connection pieces 84 and the connection pieces 82 are overlapped with each other. The bent portion 73 is directly or indirectly connected.
Further, the material container 80 includes a lid fixing mechanism that fixes the lid 5 to the container main body 90. The lid fixing mechanism of the second embodiment is configured by a notch 110 formed in the lid 5, a locking member 85, and an elastic piece 45.

The material container 80 of the second embodiment is entirely formed by integral molding of resin. Any resin can be used as the material for the material container 80 as long as it satisfies the thermoplasticity, rigidity, elasticity, transparency, solvent resistance, cost, and the like required for the material container 80. Good. Examples of the resin that satisfies such conditions include polyethylene terephthalate, thermopolyolefin, and polypropylene.
However, the second embodiment is not limited to forming the material container 80 by integral molding with resin. The material container 80 may use a material other than a resin such as a metal for the whole or a part of the material container 80.

As shown in FIG. 12, the bottom surface 83 is a bottom surface that seals the inside of the container main body 90 together with the container main body 90 containing the material. The bottom surface 83 includes at least a fragile portion 831 that can be broken. The weak part 831 of the second embodiment refers to a part where breakage is more likely to occur than the base part 832 which is another part of the bottom face 83. In the second embodiment, the fragile portion 831 is a thin film portion, and the base portion 832 is a thick film portion having a thickness larger than that of the thin film portion. By doing in this way, 2nd embodiment can form the weak part 831 which is easier to tear than the base part 832.

As shown in FIG. 13, the bottom surface 83 connects the base portion 832 that is harder to break than the weak portion 831 together with the weak portion 831, and the inner surface of the container main body 90 and the base portion 832 before and after the breakage of the weak portion 831. A connection portion 833. The connecting portion 833 is in a state where the inner surface of the container main body 90 and the base portion 832 are connected both before and after the fragile portion 831 is broken. That is, the connection portion 833 is a portion that is connected to the inner surface of the container main body 90 before the breakage and is less likely to break than the fragile portion 831. Such a connection portion 833 is connected to the inner surface of the container body 90 as a part of the bottom surface 83 before the fragile portion 831 is broken, and the fragile portion 831 is missing from the bottom surface 83 after the fragile portion 831 is broken. In this state, it remains on the inner surface of the container body 90.
In this way, it is possible to prevent the base portion 832 from being separated from the container main body 90 after the fragile portion 831 is broken and blocking the cylindrical portion 89, or a broken piece from being mixed into the material.

FIG. 14A and FIG. 14B are diagrams for explaining a process in which the bottom surface 83 is broken. FIG. 14A shows a state before the flow path convex portion 63 a shown in FIG. 10 is inserted into the cylindrical portion 89. FIG. 14B shows a state where the flow path convex portion 63 a is inserted into the cylindrical portion 89 and the bottom surface 83 is broken. In FIG. 14B, the bottom surface 83 has the weakened portion 831 broken and the periphery of the base portion 832 disappeared. For this reason, the base portion 832 is separated from the inner surface of the cylindrical portion 89 and is pushed up by the flow path convex portion 63a and turned up.
Further, a stepped portion 232 is formed in the circumferential direction in the flow path convex portion 63a. On the other hand, the cylindrical portion 89 also has a step portion 191 on the inner surface of the cylindrical portion 89 in a circumferential shape. The flow path convex portion 63 a inserted into the cylindrical portion 89 is fixed by engaging the stepped portion 232 with the stepped portion 191, and prevents the stepped portion 232 from falling off the cylindrical portion 89.
In such a state, for example, the first partial flow path 62x (see FIG. 8) formed in the inside of the container main body 90 and the flow path convex portion 63a communicates, and the material is transferred from the container main body 90 to the flow path convex portion 63a. It starts to flow.

(Flow path switching mechanism holder)
Fig.15 (a), FIG.15 (b) and FIG.15 (c) are the figures for demonstrating the holder 70 of 2nd embodiment. FIG. 15A shows a state before the flow path switching mechanism 3 of the second embodiment is held by the holder 70. FIG. 15B shows a process in which the flow path switching mechanism 3 is held by the holder 70, and FIG. 15C shows a state in which the holding of the flow path switching mechanism 3 by the holder 70 is completed.
The holder 70 holds the flow path switching mechanism 3, and the flow path switching mechanism 3 is inserted from at least one direction intersecting the row direction (y direction and −y direction) of the second member 20 in the flow path switching mechanism 3. The insertion groove 70c is alternately provided with the locking projection 70b that is locked when the flow path switching mechanism 3 inserted in the insertion groove 70c moves in the -y direction.
As shown in FIG. 15A, in the flow path switching mechanism 3, the second members 20 (FIG. 7 and the like) are arranged in a line along the y-axis. In the second embodiment, the y direction and the −y direction are referred to as the row direction of the second member 20. On the other hand, the holder 70 includes a substrate 70a that is long in the y-axis direction, and locking protrusions 70b and insertion grooves 70c that are provided on each of two sides in the longitudinal direction of the substrate 70a. The locking projections 70b and the insertion grooves 70c are alternately provided along the above sides.

In such a holder 70, in the second embodiment, the holder engaging portion 65 formed on the lower surface 61c of the flow path switching mechanism 3 is slid from the direction of the arrow B in the drawing in accordance with the insertion groove 70c. To be placed on the substrate 70a. The direction in which the flow path switching mechanism 3 is slid with respect to the holder 70 is not limited to the direction indicated by the arrow B. As other directions, the z-axis direction shown in the figure can be considered. When the flow path switching mechanism 3 is held by the holder 70 from the z-axis direction, the flow path switching mechanism 3 is placed on the substrate 70a from above with the holder engaging portion 65 aligned with the insertion groove 70c.
The holder 70 of the second embodiment is not limited to the configuration in which the flow path switching mechanism 3 is inserted into the insertion groove 70c from the orthogonal direction, and is inserted from the direction intersecting the arrangement direction of the second members 20. It may be inserted from any direction as long as it is. The insertion direction of the flow path switching mechanism 3 can be arbitrarily set according to the shape and design of the insertion groove 70c.

Next, in 2nd embodiment, as shown in FIG.15 (b), the flow-path switching mechanism 3 on the board | substrate 70a is set to the arrangement direction of the 2nd member 20 shown by the arrow C in the figure on the board | substrate 70a. Move. After the movement, the flow path switching mechanism 3 is fixed on the holder 70 as shown in FIG. More specifically, the surface of the holder engaging portion 65 of the second embodiment is a tapered surface that spreads downward from the lower surface 61c. On the other hand, the locking convex portion 70 b has a reverse tapered surface along the surface of the holder engaging portion 65 on the surface in contact with the holder engaging portion 65. When the flow path switching mechanism 3 moves in the direction of the arrow C by one locking projection 70b, the position of the holder engaging portion 65 coincides with the locking projections 70b on both sides in the short side direction of the substrate 70a. At this time, the holder engaging portion 65 and the locking convex portion 70b are engaged with each other, and the holder engaging portion 65 is locked by the locking convex portion 70b to prevent the flow path switching mechanism 3 from being detached from the holder 70. it can. Further, if the holder 70 is made of a material such as a resin having elasticity, the holder engaging portion 65 receives a force in the compression direction from the locking projections 70b on both sides, and the engagement with the locking projections 70b is achieved. It will be even stronger.
According to the holder 70 of the second embodiment as described above, in setting the flow path switching mechanism 3 at an arbitrary position of the holder 70, it is necessary to move the flow path switching mechanism 3 to the fixed position in the direction of the arrow C. Absent. For this reason, the flow path switching mechanism 3 can be easily set in the holder 70.

[Third embodiment]
Next, a third embodiment of the present invention will be described. The third embodiment relates to a material container used for the material supply unit described above. Hereinafter, prior to specific description of the material container of the third embodiment, the object of the invention of the material container of the third embodiment will be described.

Some apparatuses for synthesizing drugs by chemical treatment can cope with the synthesis of a plurality of kinds of drugs with one apparatus. In synthesizing a drug, a mechanism for supplying a material corresponding to the drug is required. Here, “material” includes substances, chemicals (reagents), catalysts, water, and the like used for the synthesis of a drug.
When synthesizing a plurality of types of drugs in one apparatus, a mechanism for supplying a material to a reaction vessel is shared by a plurality of synthesis processes. In such a mechanism, in order to easily change the material corresponding to each drug, there is a mechanism that allows an arbitrary material to be set in the supply mechanism and changes the material set according to the drug to be synthesized. In addition, in such a mechanism, the chemical used in other synthetic processes in the synthetic process or the products generated in other processes are prevented from being mixed (including contamination / carry over). Therefore, it is preferable to dispose at least a part of the supply mechanism including the material container. As a container for materials used for drug synthesis, for example, in a synthesizer described in JP 2010-270068 A (hereinafter referred to as Reference 1), a vial container is used.

In the fields of biochemistry and molecular biology, containers described in Japanese Patent Application Laid-Open No. 10-323176 (hereinafter referred to as Reference 2) and Japanese Translation of PCT International Publication No. 2014-507256 (hereinafter referred to as Reference 3). Has been used as a container for the polymerase chain reaction. Each of the containers described in Reference 2 and Reference 3 has an opening at the upper end of the container body, a lid that can open and close the opening, and the “bottom” on the side opposite to the lid of the container is closed. ing. Then, the liquid sample is injected and taken out from the opening by a pipette.

When a material is set in a vial container used in the synthesizer described in Reference 1, the rubber stopper of the vial container is sealed with an aluminum thin film or the like. In the case of a solid material, it is dissolved in a solvent, and a needle having a fluid flow path (hereinafter referred to as an “injection needle”) is inserted through a rubber stopper, so that the flow path on the material supply mechanism side and the vial bottle Circulates the inside.
However, when the material is accommodated in the vial container in this way, the remaining amount of the material remaining in the vial container becomes a problem as the amount of liquid supplied to the supply mechanism decreases.
In addition, in the containers described in Reference 2 and Reference 3, it is assumed that a liquid sample is injected and removed by a pipette, and it is assumed that there is no application to a material supply mechanism for a flow path of an automated synthesizer. Not.
The third embodiment has been made in view of the above points, and relates to a material container that has a small amount of remaining material and that can be easily detached from the material supply mechanism. The third embodiment relates to a material supply unit using such a material container.

Hereinafter, a third embodiment of the present invention will be described with reference to the drawings. In all the drawings, the same constituent elements are denoted by the same reference numerals, and redundant description is omitted as appropriate. In the third embodiment, the material container 1001 and the material supply unit 1004 have the lid 1005 side up and the receiving member 1002 side with respect to the material container 1001 down while the material container 1001 is set on the receiving member 1002. To do. Such a vertical direction is determined regardless of the direction of gravity.
16 to 24 shown in the third embodiment are for the purpose of explaining the mechanism of the material container 1001 and the material supply unit 1004 and the arrangement relationship thereof, and the length and thickness of each member. In addition, the width and the like are not necessarily shown accurately.

[Material supply unit]
FIG. 16 is a perspective view for explaining the material supply unit 1004 of the third embodiment. The material supply unit 1004 includes a material container 1001 according to the third embodiment, a convex portion 1023a that breaks the fragile portion 1031 (FIGS. 22 and 23) of the material container 1001, and an internal portion of the convex portion 1023a. 1023a has a receiving member 1002 having a flow path 1231 (FIG. 24) communicating with the material container 1001 in a state in which the fragile portion 1031 is broken and inserted into the bottom surface 1003. The open end of the flow path 1231 is opened at the tip of the convex portion 1023a.
In 3rd embodiment, the material container 1001 shall be used for the synthesis | combination of the compound or chemical | medical agent by a chemical process, and the use for mixing of food and drink of the material container 1001 is remove | excluded. Further, when the material container 1001 is used for the synthesis of a radioactive compound or a radiopharmaceutical (including a polymer or an antibody labeled with a radionuclide, hereinafter collectively referred to as “radiopharmaceutical or the like”), the material container 1001 is used. Contains synthetic materials such as these radiopharmaceuticals. Examples of synthetic materials such as radiopharmaceuticals include substances (labeling precursors, etc.), chemicals (reagents), catalysts, water and the like used for the synthesis of radiopharmaceuticals.

The receiving member 1002 is a member that is set in a synthesizer (not shown) such as a radiopharmaceutical and supplies a material used for a chemical reaction to the synthesizer. The receiving member 1002 includes a main body 1021 having at

least wall surfaces

1021a, 1021b, 1021c, 1021d, and 1021e, a convex portion 1023a provided on the wall surface 1021a of the main body 1021, and a convex portion 1023e provided on the wall surface 1021e. The receiving member 1002 includes a through hole 1042 having a rectangular cross-sectional shape provided in the main body 1021 and a switching unit 1043 inserted through the through hole 1042. The switching unit 1043 has a flow path (not shown), and in both directions of an axis orthogonal to the length direction of the receiving member 1002 so as to contact and separate the flow path and the flow path 1231 formed in the convex portion 1023a. It is movable. The switching unit 1043 is moved by pushing or pulling the grip portion 1041 by an actuator or the like (not shown).

The material container 1001 includes a container body 1010 (FIGS. 17, 18, and 21) that is a container body that is long in the vertical direction. The container body 1010 connects a cylindrical portion 1017 having a cylindrical shape with a constant outer diameter and inner diameter, a cylindrical portion 1019 having a constant outer diameter and inner diameter smaller than the cylindrical portion 1017, and the cylindrical portion 1017 and the cylindrical portion 1019. And a tapered portion 1018 having an inclined surface. A bottom surface 1003 is provided between the boundary between the tapered portion 1018 and the cylindrical portion 1019 and the lower end portion 1049 of the cylindrical portion 1019.

The material container 1001 includes a lid 1005 at the upper end. An abutting portion 1016 that abuts on the lid plate 1011 of the lid portion 1005 and closes the container main body 1010 is provided at the upper end of the cylindrical portion 1017. In addition, the lid 1005 is bent so that the connection piece 1014 and the connection piece 1012 overlap between the

connection pieces

1014 and 1012 and the connection piece 1014 and the connection piece 1012 that connect the lid part 1005 and the cylinder part 1017. The bent portion 1013 is directly or indirectly connected.
In addition, the material container 1001 includes a lid fixing mechanism that fixes the lid 1005 to the container body 1010. The lid fixing mechanism of the third embodiment is configured by a notch 1110 formed in the lid 1005, a locking member 1015, and an elastic piece 1045 (FIG. 18).

In the material supply unit 1004 described above, the receiving member 1002 has a plurality of convex portions 1023a having a convex shape. The material container 1001 includes a bottom surface 1003 (FIGS. 17 to 23) inside the cylindrical portion 1019. In the third embodiment, the material container 1001 can be set on the receiving member 1002 by inserting the convex portion 1023 a through the bottom surface 1003. With such a configuration, the material container 1001 can be easily set on the receiving member 1002.

Moreover, since the material container 1001 of the third embodiment takes out the material by breaking the bottom surface, it is possible to secure a relatively large diameter material flow path. For this reason, the third embodiment can reduce the remaining amount of the container body 1010 in the container body 1010. Moreover, since the material container 1001 can be arbitrarily replaced with respect to the receiving member, the material can be easily attached to and detached from the supply mechanism.
In the third embodiment, a material container 1001 that stores an arbitrary material corresponding to a synthesized radiopharmaceutical or the like is set on the receiving member 1002, and a material that accommodates another material when synthesizing another radiopharmaceutical or the like. The container 1001 can be set on the receiving member 1002. If it does in this way, the material which should be supplied according to the radiopharmaceuticals etc. which a synthesizer synthesizes can be changed simply. Furthermore, in the third embodiment, the material container 1001 and the receiving member 1002 are made disposable, thereby preventing contamination due to materials, residues, and products in the synthesis apparatus.

[Container body]
Next, the material container 1001 shown in FIG. 16 will be described.
FIGS. 17, 18, 19, 20, 21, and 22 are diagrams for explaining the configuration of the material container 1001 according to the container body 1010. 17 and 18 are perspective views of the material container 1001. FIG. 17 shows a state in which the lid 1005 closes the opening 1047, and FIG. 18 shows a state in which the lid 1005 opens the opening 1047. ing. FIG. 19 is a top view of the material container 1001 shown in FIG. 18 viewed from the direction of arrow IV. 20 is a bottom view of the material container 1001 shown in FIG. 21 is a cross-sectional view taken along the arrow VI of the material container 1001 shown in FIG. 18, and FIG. 22 is an enlarged view of the container main body 1010 shown by enlarging the range surrounded by the broken line VII shown in FIG. It is. 23 is an enlarged view of the bottom surface 1003 shown in FIG. 22 as viewed from the direction of the arrow V in FIG.

As shown in FIGS. 16, 17, and 18, the material container 1001 is a bottomed container that accommodates a material used for chemical processing.
The container body 1010 and the bottom surface 1003 have a circular shape when viewed from above. The inner diameter of the container body 1010 is larger than the diameter of the bottom surface 1003. In addition, in 3rd embodiment, although the internal diameter of the container main body 1010 is constant, the inner diameter of the container main body 1010 may change. When the inner diameter of the container body 1010 changes, this inner diameter is larger than the diameter of the bottom surface 1003 at any location. In other words, the minimum inner diameter of the container body 1010 is smaller than the diameter of the bottom surface 1003.

That is, the material container 1001 has a container body 1010. The container main body 1010 includes a cylindrical portion 1017, a tapered portion 1018, and a cylindrical portion 1019, and all of the cross sections orthogonal to the longitudinal directions of the cylindrical portion 1017, the tapered portion 1018, and the cylindrical portion 1019 have a circular shape. Yes. The diameters of the cross sections of the cylindrical portion 1017, the tapered portion 1018, and the cylindrical portion 1019 become smaller in the order of the cylindrical portion 1017, the tapered portion 1018, and the cylindrical portion 1019. The tapered portion 1018 forms a part of a cone that becomes thinner from the lower end portion of the cylindrical portion 1017 toward the upper end portion of the cylindrical portion 1019.
The third embodiment is not limited to the above configuration. For example, the third embodiment may be a cylindrical body in which the tapered portion 1018 has a constant diameter, or may be a tapered cylinder whose inclination changes. Also, the diameter of the cylindrical portion 1019 may be constant or change.

The material container 1001 of the third embodiment provides a pressure difference between the inside of the container body 1010 and the material supply destination, and promotes the outflow of the material by the pressure difference. At this time, in the third embodiment, the container main body 1010 includes the cylindrical portion 1019, whereby the flow of a gas such as helium can be concentrated toward the cylindrical portion 1019 to promote the outflow of the material.
With the above configuration, in the third embodiment, the material smoothly flows out from the cylindrical portion 1019 along the inner peripheral surface of the tapered portion 1018, and the remaining amount of the material in the container body 1010 can be further reduced.

As shown in FIG. 18, a fitting portion 1111 is formed on the side of the lid 1005 facing the inside of the container body 1010 of the lid plate 1011. The fitting portion 1111 is fitted to the contact portion 1016 so that the outer peripheral surface is in contact with the inner peripheral surface of the contact portion 1016, and the contact surface 1112 of the fitting portion 1111 and the contact surface on the contact portion 1016 side. 1162 contacts and closes the opening 1047. The lid fixing mechanism of the lid portion 1005 with the opening 1047 closed will be described later.

[Bottom]
In addition, the container body 1010 includes a bottom surface 1003 as shown in FIGS. As shown in FIGS. 17, 18, 21, and 22, the bottom surface 1003 is a container main body 1010 that contains a material and a bottom surface that seals the inside of the container main body 1010. The bottom surface 1003 is provided at a distance from the lower end portion 1049 of the cylindrical portion 1019 and is prevented from being damaged.

The bottom surface 1003 includes at least a fragile portion 1031 that can be broken, as shown in FIGS. 20 and 23. The fragile portion 1031 of the third embodiment is a portion where breakage is more likely to occur than the base portion 1032 which is another portion of the bottom surface 1003. In the third embodiment, the fragile portion 1031 is a thin film, and the base portion 1032 is a thick film having a thickness larger than the thickness of the fragile portion 1031. By doing in this way, 3rd embodiment can form the weak part 1031 which is easier to tear than the base part 1032.

However, the fracture of the third embodiment does not only indicate that the bottom surface 1003 is torn, but also indicates that the bottom surface 1003 is in a state in which material movement occurs between the tapered portion 1018 and the cylindrical portion 1017. For this reason, the fracture of the bottom surface 1003 includes the tearing or breaking of the bottom surface 1003. Further, “breakable” in the third embodiment means that the bottom surface 1003 can be broken by inserting a protrusion into the cylindrical portion 1019. The protrusions may be the protrusions 1023a, or the protrusions 1023a may be inserted into the cylindrical part 1019 after the other protrusions are used to break 1003.
The weak part which is easy to tear than other parts can be formed, for example by using the member which is easy to tear in one direction rather than another part for a weak part. The weak part that is more easily broken than the other part is formed, for example, by forming a part with a thinner film thickness than the other part in a linear shape, and applying pressure to the part surrounded by the line, so that the bottom surface 1003 follows the line. It can be formed by cracking.

Further, as shown in FIG. 23, the bottom surface 1003 includes a base portion 1032 that is less likely to break than the fragile portion 1031 and a connection portion 1033 that connects the inner peripheral surface of the container body 1010 and the base portion 1032 before and after the fragile portion 1031 is broken. And further.
Further, as shown in FIG. 23, the weakened portion 1031 of the third embodiment is disposed on the outer side in the radial direction of the bottom surface 1003 with respect to the base portion 1032. With such a configuration, in the third embodiment, the periphery of the bottom surface 1003 is broken so that the central portion 1032 is separated from the container body 1010 and the separated base 1032 is kept inside the container body 1010. Can do. That is, in the configuration in which the periphery of the bottom surface 1003 is the base and the central portion is the weakened portion 1031, the weakened portion 1031 is broken and separated from the base, and the position of the broken piece after the breakage cannot be controlled. Further, in a configuration in which the periphery of the bottom surface 1003 is a base portion and the central portion is a fragile portion, the base portion 1032 remains on the inner peripheral surface of the cylindrical portion 1019, and the inner diameter of the cylindrical portion 1019, that is, the material flow path seems to be narrowed. In the third embodiment in which the weakened portion 1031 is provided outside the base portion 1032, the broken weakened portion 1031 does not remain on the inner peripheral surface of the cylindrical portion 1019, and the diameter of the material flow path can be ensured. Such a configuration is effective in reducing the remaining amount of material remaining in the container body 1010.

Further, as shown in FIG. 23, the third embodiment has a portion 1034 that is gently bent so that the shape of the outer edge of the connection portion 1033 is convex inward toward the base portion 1032. With such a configuration, the third embodiment can prevent the material from remaining around the connection portion 1033, and thus reduce the remaining amount of the material in the container body 1010.

In addition, as shown in FIG.19, FIG20 and FIG.22, the bottom face 1003 of 3rd embodiment has the level | step difference between the weak part 1031 and the base 1032 only in the lower side. That is, in the bottom surface 1003, the base portion 1032 is thicker toward the lower side. Such a shape of the bottom surface 1003 depends on the formation process of the material container 1001, and the base portion 1032 may be thicker toward the upper side of the bottom surface 1003. Moreover, you may become thick toward both sides. However, it is preferable from the viewpoint of reproducibility of the fracture position that the thicknesses of the fragile portion 1031 and the base portion 1032 change sharply at a position where the fracture is desired.

In the third embodiment, the connecting portion 1033 described above is formed of a continuous thick film with the base portion 1032. By doing so, the connection portion 1033 has the same strength as the base portion 1032, and the fragile portion 1031 can be broken before the connection portion 1033 and the base portion 1032 are broken. Further, when the material container 1001 is integrally formed by injection molding with resin or the like, it is advantageous from the viewpoint of resin filling property and the like to form the connection portion 1033 with the same thickness as the base portion 1032.
The third embodiment is not limited to the configuration described above. For example, the third embodiment can obtain the effect of reducing the material remaining in the container main body 1010 even if the entire bottom surface 1003 is the weakened portion 1031.

In the above configuration, the bottom surface 1003 is formed between the boundary between the tapered portion 1018 and the cylindrical portion 1019 and the lower end portion 1049. Such a position of the bottom surface 1003 is an appropriate position for pushing up the bottom surface 1003 to break the fragile portion 1031 after the convex portion 1023a is engaged with the stepped portion 1191. For example, when the bottom surface 1003 is closer to the lower end portion 1049, there is no possibility that the convex portion 1023a is inserted and fixed, and there is a possibility that the convex portion 1023a may vary in the direction in which pressure is applied to the bottom surface 1003. Therefore, in the third embodiment, the convex portion 1023a can always apply force to the bottom surface 1003 from the optimum direction. Note that the optimum direction of the third embodiment is a direction perpendicular to the bottom surface 1003.

[Lid fixing mechanism]
Next, the lid fixing mechanism of the third embodiment will be described.
FIG. 24A, FIG. 24B, and FIG. 24C are views for explaining the lid fixing mechanism of the third embodiment. 24A shows a state in which the lid portion 1005 opens the opening portion 1047, FIG. 24B shows a state in which the opening portion 1047 is closed by the lid plate 1011 of the lid portion 1005, and FIG. A state in which the cover plate 1011 is fixed is shown.
As described above, the container main body 1010 is provided with the bottom surface 1003 at one end in the axial direction perpendicular to the bottom surface 1003. In addition, an opening 1047 is provided at the other end, and the opening 1047 is closed by a lid 1005 having a lid plate 1011 parallel to the bottom surface 1003. The lid fixing mechanism of the third embodiment includes a notch 1110 formed on the outer surface of the lid plate 1011, an elastic piece 1045 connected to the container body 1010, and a notch 1110 provided at the tip of the elastic piece 1045. And a locking member 1015 having a portion larger than the width w of the notch. The elastic piece 1045 is held in the notch 1110 and fixed to the outer surface of the lid plate 1011 by the locking member 1015 in an extended state.

Specifically, as shown in FIGS. 24A to 24C, a notch 1110 is formed in the cover plate 1011 of the third embodiment. As shown in FIGS. 19 and 20, the cutout portion 1110 of the third embodiment has a “U” shape in plan view. However, the third embodiment does not limit the shape of the notch 1110 in a closed view. The shape of the notch 1110 may be any shape as long as the elastic piece 1045 can be held.
A locking member 1015 having a portion larger than the notch width w of the notch 1110 is connected to the tip of the elastic piece 1045. The locking member 1015 of the third embodiment is a sphere, and the diameter from the portion very close to the boundary with the elastic piece 1045 to the portion very close to the outer surface on the opposite side is larger than the width w of the notch.

In the above configuration, first, as shown in FIG. 24B, the user of the material container 1001 closes the opening 1047 with the lid 1005 so that the lid 1011 overlaps the opening 1047. Next, the user fits the elastic piece 1045 into the cutout portion of the cutout portion 1110 as shown in FIG. In the third embodiment, when the user fits the elastic piece 1045 into the notch 1110, the elastic piece 1045 and the like are designed so as to extend the elastic piece 1045 while pulling the locking member 1015 upward. deep. In this way, even when the user is not applying force to the locking member 1015 and the elastic piece 1045, the locking member 1015 is prevented from hitting the notch 1110 and the elastic piece 1045 is prevented from returning to the state before extension. It is out. For this reason, the elastic piece 1045 of the third embodiment is fixed in an extended state on the outer surface of the lid plate 1011.
With the above configuration, in the material container 1001 of the third embodiment, the lid 1005 is in close contact with the opening 1047, and the airtightness and liquid tightness of the container main body 1010 can be improved.

As described above, the material container 1001 according to the third embodiment can secure a flow path for a relatively large diameter material because the bottom surface 1003 is broken and the material is taken out. For this reason, the third embodiment can reduce the remaining amount of the container body 1010 in the container body 1010. Moreover, since the material container 1001 and the material supply unit 1004 can be arbitrarily replaced with respect to the receiving member, the material container 1001 and the material supply unit 1004 can be easily attached to and detached from the material supply mechanism.

[Fourth embodiment]
Next, a fourth embodiment of the present invention will be described. 25 and 26 are views for explaining the flow path switching mechanism 7 according to the fourth embodiment of the present invention. 25 is a perspective view of the flow path switching mechanism 7, and FIG. 26 is an exploded perspective view of the flow path switching mechanism 7 shown in FIG.
As shown in FIGS. 25 and 26, the flow path switching mechanism 7 is configured by combining the first member 30 and the second member 40 in the same manner as in the first and second embodiments. The combination of the first member 30 and the second member 40 is performed by inserting the second member 40 through the hollow portion 36.
The second member 40 includes a rectangular parallelepiped main body 44 having an upper surface 41a, side surfaces 41b and 41d, a lower surface 41c, a front surface 41e, and a back surface 41f, and a driving force receiving convex portion 47 is formed on the front surface 41e of the main body 44. The first member 30 has a main body 34 having an upper surface 31a, side surfaces 31b and 31d, a lower surface 31c, a front surface 31e, and a back surface 31f. The main body 34 is a frame body having a predetermined thickness and has a hollow portion 36. For this reason, the front surface 31e and the back surface 31f have a frame shape.
Channel

convex portions

331a and 332a are formed on the upper surface 31a, and channel

convex portions

331d and 332d are formed on the side surface 31d. A holder engaging portion 35 is formed on the lower surface 31c.

The first member 30 has first

partial flow paths

321a, 322a, 321d, and 322d. The first partial flow path 321a has openings 321aa and 321ab at both ends, and the first partial flow path 322a has openings 322aa and 322ab at both ends. The first partial flow path 321d has openings 321da and 321db at both ends, and the first partial flow path 322d has openings 322da and 322db at both ends. The second member 40 has second

partial flow paths

42a and 42b. The second partial flow path 42a has an opening 42aa on the upper surface 41a and an opening 42ab on the side surface 41d. The second partial flow path 42b has an opening 42ba on the upper surface 41a and an opening 42bb on the side surface 41d.
In the fourth embodiment, the pre-movement communication channel that is the first partial channel that communicates with the second partial channel when the second member 40 is at the predetermined position, and the second member along the axis from the predetermined position. And a post-movement communication channel that is a first partial channel that communicates with the second partial channel. In the above configuration, the first

partial flow paths

321a and 321d are communication paths before movement of the fourth embodiment, and the first

partial flow paths

322a and 322d are communication paths after movement.

For example, in the fourth embodiment, fluid is introduced into the second partial flow path 42a at a position communicating with the first

partial flow paths

321a and 321d. The introduction of the fluid is performed by providing a pressure difference between the second partial flow path 42a and the introduction destination of the fluid. After the second partial flow path 42a is filled with fluid, in the fourth embodiment, the second member 40 is moved along the x axis, and the second partial flow path 42a is moved to the first partial flow path 322a or the first partial flow. The fluid in the second partial channel 42a is led out from the path 322d to a different destination from the fluid introduction source.
Such a configuration is useful when sampling a portion of a fluid in the course of a chemical reaction in small amounts. That is, in the fourth embodiment, if the flow path switching mechanism 7 is connected to a reaction vessel or the like for chemical reaction, the reaction can be sampled without stopping the reaction or opening the vessel. it can.
FIG. 27 is a diagram showing a micro sampling system using the flow path switching mechanism 7 of the fourth embodiment. FIG. 28 is a view for explaining the fluid flowing through the flow path switching mechanism 7 in the micro sampling system of FIG. In FIG. 27, a capillary 107 is a glass capillary filled with silica gel, and is manufactured and sold by, for example, Future Chem under the trade name of Radio-Cap. The capillary 107 and the flow path switching mechanism 3 are connected by a liquid transfer tube 109, and the fluid moves between the capillary 107 and the liquid transfer tube 109 or the outside of the flow path switching mechanism 7 via the liquid transfer tube 109. To do.
In addition, the reaction liquid is stored in the reactor 103, and various organic reactions proceed in the solvent in the reaction liquid. Further, the developing solvent container 105 is filled with a developing solvent for chromatography that is blended suitable for analysis of the target compound.
The procedure for using the micro sampling system shown in FIGS. 27 and 28 will be described below. First, the inside of the reactor and the second partial channel 42a is depressurized through the channel convex portion 331a, so that the inside of the second partial channel 42a is filled with the reaction solution (FIG. 28, arrow E). Next, the flow path 42a is connected to the openings 322ab and 322da by moving the driving force receiving convex portion 47 in the −x direction. Then, by reducing the pressure in the capillary 107 through the developing solvent container 105 and the material supply unit 100, the reaction solution and the developing solvent are introduced into the capillary 107 (arrows D, F, G, H), These components are developed in the capillary 107 together with a developing solvent. When the developing solvent is developed to a predetermined distance (height) in the capillary 107, the decompression is stopped, the capillary 107 is removed, and detection is performed with a detector suitable for the target compound. For example, a radio TLC scanner can be used to detect a compound that emits radiation. Thereafter, when the driving force receiving convex portion 47 is pushed in and further reaction tracking is performed, the same operation is repeated.

As described above, in the configuration of the fourth embodiment, since the fluid under reaction can be sampled over time over a plurality of times, changes in the component of the fluid over time due to the reaction can be tracked. According to the tracking of changes in the components of the fluid over time, it is determined whether the reaction rate of the fluid is a desired rate, and the reaction is controlled to a desired state by feeding back conditions such as heating and the amount of reagent to be introduced. be able to.
Further, in the above-described configuration, if an amount of fluid that satisfies the second partial flow path 42a is collected, the second partial flow path 42a is separated from the first partial flow path 321a and the first partial flow path 321d. Then, the fluid filling the second partial channel 42a is led out in communication with the first partial channel 322a and the first partial channel 322d. For this reason, 4th embodiment can send the quantity of the fluid which fills the 2nd partial channel 42a correctly to a sampling solution.
The above operation can also be performed by moving the second partial flow path 42b from a position communicating with the first

partial flow paths

322a and 322d to a position communicating with the first

partial flow paths

321a and 321d.

[Fifth embodiment]
FIG. 29A and FIG. 29B are views for explaining the first member 50 and the second member 20 of the fifth embodiment. FIG. 29A is a perspective view of the first member 50 of the fifth embodiment, and FIG. 29B is a perspective view of the second member 20. The second member 20 shown in FIG. 29 (b) is the same member as the second member 20 shown in FIG. 1 (c).
As shown in FIG. 29A, the first member 50 is combined with the second member 20 to constitute a flow path switching mechanism. In the first member 50, first

partial flow paths

12a, 12b, and 12d are formed. The second member 20 moves in the ± x direction in FIG. 29 so that any one of the second

partial flow paths

22a, 22b, and 22c of the second member 20 is combined with the first

partial flow paths

12a, 12b, and 12d.
When the first partial flow path 12a is combined with the second partial flow path 22a, flow paths 12a-22a-12d are formed. Further, when the first partial flow path 12a is combined with the second partial flow path 22c, the flow paths 12a-22c-12b are formed, and when the first partial flow path 12b is combined with the second partial flow path 22b, the flow is Paths 12b-22b-12d are formed.

The first member 50 is at least partially a frame, and in the fifth embodiment, the entire main body 14 has a frame shape. Here, the frame refers to a shape that partially surrounds at least one space. That is, the frame referred to in the fifth embodiment does not cover the entire space. For example, as shown in FIG. 29A, the hollow portion 16 is a space into which at least a part of the second member 20 is inserted. Is enclosed except for the surface facing in the ± x direction. Further, the frame that is the first member 50 includes a reference strain portion having a predetermined rigidity and an easy strain portion 55 having a rigidity smaller than that of the reference strain portion.

In FIG. 29A, the easy strain portions 55 are formed one by one at the four corners of the main body 14. The reference distortion portion referred to in the fifth embodiment is a portion excluding the easy distortion portion 55 in the main body 14.
In the fifth embodiment, the rigidity of the easy strain portion 55 is reduced by making the thickness of at least a part of the easy strain portion 55 thinner than the thickness of the reference strain portion. In FIG. 29A, the easy strain portion 55 includes two thin portions 55 a, and the two thin portions 55 a are thinner than other portions of the main body 14. In the fifth embodiment, a thicker portion than the thin portion 55a of the reference strain portion is shown as the thick portion 55b.
The frame-shaped main body 14 is spread in all directions when the second member 20 is inserted by forming the easy strain portion 55. At this time, the thick portion 55b is not locally distorted, and the entire thick portion 55b spreads toward the outside of the frame.

The easy strain portion 55 is a portion having lower rigidity than the reference strain portion and a larger strain amount than the reference strain portion. Here, “rigidity” refers to the magnitude of distortion when an external force is applied in the inner and outer directions. The “distortion amount” refers to, for example, a deformation amount before and after distortion when the easy strain portion 55 and the reference strain portion are distorted by applying the same force.
The shape of the thin portion 55a is not limited to the shape shown in FIG. For example, in the fifth embodiment, the width, thickness, and number of the thin portion 55a may be arbitrary. In the fifth embodiment, a cut may be formed instead of the thin portion 55a to reduce the rigidity of the easy strain portion 55. In such a case, the rigidity of the easy strain portion 55 can be adjusted by the number of cuts and the depth.

Moreover, the reference distortion part and the easy distortion part 55 which the 1st member 50 of 5th embodiment has may be provided in the main body of the 1st member 30 of 3rd embodiment, and has the reference distortion part and the easy distortion part 55. It can also be used as the above minute sampling system by using the flow path switching mechanism comprising the first member 30.

Further, the fifth embodiment is not limited to the one in which the rigidity of the easy strain portion 55 is adjusted by the thickness. For example, the rigidity of the main body 14 may be such that the hardness of the material of the main body 14 differs between the easy strain portion 55 and the reference strain portion. Further, in the fifth embodiment, a hole may be opened in a part of the main body 14 to form the easy distortion portion 55. In this case, the rigidity of the easy strain portion 55 can be adjusted by the number and diameter of the openings.

[Sixth embodiment]
Next, a sixth embodiment of the present invention will be described. FIG. 30 is a diagram showing a flow path switching system including the flow path switching apparatus 2 of the sixth embodiment. The flow path switching device 2 is used with the flow path switching mechanism and the material container 80 described above attached thereto, and an application example thereof is a radiopharmaceutical synthesis apparatus. The flow path switching mechanism 4 attached to the flow path switching device 2 is combined with the first member in which one or a plurality of first partial flow paths are formed and the first member in a movable state. By combining the second member having the two-part flow path, the driving force receiving portion for receiving the driving force for moving the second member in both directions of one axis, the first member and the second member, The channel and the second partial channel communicate with each other to form a channel, and the second member moves in both directions of one axis while maintaining the combination of the first member and the second member. Any combination may be used as long as the combination of the partial flow path and the second partial flow path is changed to switch the flow path to another flow path.
The flow path switching device 2 shown in FIG. 30 has a unit body 8 and a base 9 on which the unit body 8 is placed and fixed. The unit body 8 includes three flow path switching

mechanism holding units

8A, 8B, and 8C. In the sixth embodiment, it is assumed that the flow path switching

mechanism holding units

8A, 8B, 8C all have the same configuration. For this reason, in the sixth embodiment, the flow path switching mechanism holding unit 8A will be described below and replaced with the description of the flow path switching mechanism holding unit 8B and the flow path switching mechanism holding unit 8C.

The flow path switching mechanism holding unit 8A includes a holding surface 912 that holds the flow path switching mechanism 4 of the sixth embodiment, and a holder 240 that abuts the flow path switching mechanism 4 from the x direction (front) in FIG. 31) holder wall 240c. Engagement holding portions 911 that engage with the flow path switching mechanism 4 and function as stoppers of the flow path switching mechanism 4 are provided at both ends of the flow path switching mechanism 4 on the holding surface 912. The holding surface 912 has a length corresponding to the length of the flow path switching mechanism 4 in the y direction, and the flow path switching mechanism 4 is placed so as to be set between the engagement holding portions 911. Such an engagement holding portion 911 is used for positioning when the flow path switching mechanism 4 is attached to the flow path switching device 2 and has a function of fixing the flow path switching mechanism 4.
Further, the flow path switching mechanism 4 can set the material container 80 and the solid phase extraction cartridge on the second member. In FIG. 30, a material container 80 is set on a part of the second member of the flow path switching mechanism 4, and a liquid transfer tube 109 communicating with the flow path formed by the flow path switching mechanism 4 is provided on the material container 80 and the like. Although the example which connected is shown, the position, number, and combination are not limited to this, Various can be selected according to the objective.
Furthermore, the flow path switching device 2 according to the sixth embodiment may include a thin-layer chromatography holding unit.

The flow path switching mechanism holding unit 8A overlaps and is integrated with the flow path switching mechanism holding unit 8B and the flow path switching mechanism holding unit 8C to form a unit body 8, and is fixed to the mounting surface 91 of the base 9. At this time, the flow path switching mechanism holding unit 8 </ b> A may be indirectly fixed to the placement surface 91 via the flow path switching mechanism holding units 8 </ b> B and 8 </ b> C. It may be fixed directly. Such flow path switching

mechanism holding units

8A, 8B, and 8C are each a flow path switching mechanism installation body to which the flow path switching mechanism 4 is attached. A plurality of the flow path switching

mechanism holding units

8A, 8B, and 8C are integrated while being displaced in the x direction. In FIG. 30, three flow path switching

mechanism holding units

8A, 8B, and 8C are stacked. However, the number of flow path switching mechanism holding units is arbitrary, and the operability and the number of material containers 80 used are the same. It is determined accordingly. Further, the flow path switching

mechanism holding units

8A, 8B, and 8C are not limited to those placed on the pedestal 9, and may be installed in any manner that does not impair operability and stability. Good.

The pedestal 9 has three side surfaces 95 (only the left side surface is visible in FIG. 30) perpendicular to the placement surface 91, and the three side surfaces 95 surround three sides of the space 99. A small pedestal 94 is provided in a space 99 surrounded on three sides by a side surface 95, and a reaction vessel 481 is set on the small pedestal 94. Around the reaction vessel 481, a cover 48n attached to the small pedestal 94 may be disposed. The inside of the small pedestal 94 includes a temperature control mechanism for heating or cooling the reaction vessel 481, a stirring mechanism for stirring the reaction solution in the reaction vessel, a radiation detection mechanism used when performing a labeling reaction using a radionuclide, and the like. You may prepare. The pedestal 9 has a container support portion 93 that supports the reaction container 481. The reaction container 481 includes a rubber septum 481a and a container body 481b sealed with the rubber septum 481a. The rubber septum 481a is formed with a tube insertion port 481c through which a reagent, an inert gas or the like contained in the material container 80 circulates or a reaction solution in the reaction container 481 is taken in and out.
A plurality of connection ports 96 for connecting a tube (not shown) to a gas supply mechanism for supplying an inert gas used for adjusting the pressure in the container body 481b and a decompression mechanism are formed above the three reaction containers 481. ing.

FIG. 31 to FIG. 34 are diagrams for explaining a configuration relating to driving of the flow path switching device according to the sixth embodiment.
FIG. 31 is a diagram for explaining the inside of the flow path switching mechanism holding unit 8A, and shows the state excluding the upper surface 8Aa of the flow path switching mechanism holding unit 8A shown in FIG. 30 in the z direction. FIG. 6 is a top view seen from below (−z direction). FIG. 31 shows a state where the flow path switching mechanism 4 is attached to the flow path switching mechanism holding unit 8A, and a state where the flow path switching mechanism 4 is not attached to the flow path switching

mechanism holding units

8B and 8C. Is shown. Moreover, in FIG. 31, illustration of the material container 80 attached to the flow path switching mechanism 4 of the flow path switching mechanism holding unit 8A is omitted.

The flow path switching mechanism holding unit 8A is internally pushed by the motor 200, a coupling 222 that is connected to a gear head (not shown) of the motor 200, a ball screw portion 220 that is connected to the other of the coupling 222, and the ball screw portion 220. The bearing part 230 to be pulled is provided. In the sixth embodiment, the flow path switching mechanism 4 including a plurality of second members 20 (10 pieces) is attached to the flow path switching device 2. The motor 200, the ball screw part 220, and the bearing part 230 function as a drive part, and are provided ten in correspondence with each of the ten second members 20. The motor 200, the ball screw part 220, and the bearing part 230 corresponding to one second member 20 are shown in the figure as the individual driving part 6.

FIG. 32 is an exploded perspective view for explaining the flow path switching mechanism 4 of the sixth embodiment attached to the flow path switching mechanism holding unit 8A. FIG. 33 is a view for explaining the flow path of the first member 46 of FIG. 32. As shown in FIGS. 32 and 33, the flow path switching mechanism 4 is configured by combining the first member 46 and the second member 20. In the flow path switching mechanism 4, a plurality of second members 20 are arranged in the y-axis direction in the drawing and combined with the first member 46. The first member 46 has an upper surface 41a, side surfaces 41b and 41d, a lower surface 41c, a front surface 41e, and a back surface 41f. A hollow portion 67 is formed in the first member 46, and the front surface 41 e and the back surface 41 f have a frame shape corresponding to the plurality of hollow portions 67. Channel convex portions 43a are formed on the upper surface 41a, and channel

convex portions

43b and 43d are formed on the side surfaces 41b and 41d, respectively. Further, a holder engaging portion 69 is formed on the lower surface 41c.
As shown in FIG. 33, the main body 44 of the first member 46 has a first

partial flow path

52a, 52b, 52c, 52d, 52e, 52f, 52g, 53h, 52i, 52j, 52k, 52o, 52p, 52q, 52r, 52s, 52t, 52u, 52v, 52w, 52x are formed, and the first partial flow paths 52a to 52x communicate with the hollow portion 67, respectively. The hollow portion 67 is formed with openings 52ab to 52jb, openings (not shown) opened to face the openings 52ab to 52jb, and openings (not shown) of the first partial flow paths 52o to 52x. ing. In the sixth embodiment, similarly to the second embodiment, the second member 20 is inserted into the hollow portion 67, and the first partial flow channel communicates with the second partial flow channel of the second member 20 inside the hollow portion 67. To form a flow path.
However, the flow path switching mechanism 4 of the sixth embodiment is provided with an upper concave portion 48a and a lower concave portion 48b between the hollow portions 67 arranged adjacent to each other among the plurality of hollow portions 67 arranged in the y direction. This is different from the flow path switching mechanism 3 of the second embodiment. As will be described later, the lower concave portion 48b is a space for receiving the locking convex portions 280ab and 280bb (FIG. 35) formed in the flow path switching mechanism holding / receiving portion 280 (FIG. 35).

FIG. 34 is a schematic diagram for explaining that the second member 20 of the flow path switching mechanism 4 is driven in the flow path switching mechanism holding unit 8A, and shows the individual driving unit 6 shown in FIG. Yes. As shown in FIG. 34, the flow path switching mechanism 4 is placed on the holding surface 912 via a holder 240, and the holder 240 is a removal flow path switching for facilitating the removal of the flow path switching mechanism 4. A mechanism holding receiving portion 280 is provided.
As shown in FIG. 31, the flow path switching device 2 includes a motor 200, a coupling 222, a ball screw part 220, and a bearing part 230. Although the illustrated ball screw portion 220 is not illustrated, the ball screw portion 220 includes a ball, a shaft portion 220a, and a screw portion 220b (not shown). The bearing 230 is integrated with the holder 240. In FIG. 34, the coupling 222 is not shown.

Of the above-described configuration, the motor 200, the ball screw portion 220, and the bearing portion 230 generate the driving force for moving the second member 20 in the + and − directions of the x axis, and the driving force receiving convex portion 27 of the flow path switching mechanism 4. It functions as a drive part given to. In the sixth embodiment, this driving force is applied to the driving force receiving convex portion 27 via the holder 240 integrated with the bearing

portions

230 and 230. The channel switching mechanism holding / receiving portion 280 provided in the holder 240 holds the first member 46 so that it does not move while the second member 20 of the channel switching mechanism 4 is stationary and driven by the driving unit. .

In the sixth embodiment, the flow path switching mechanism 4 including the plurality of second members 20 is attached to the flow path switching device 2. The motor 200, the ball screw part 220, and the bearing part 230 that function as drive parts include a plurality of individual drive parts 6 that individually drive the plurality of second members 20.

The above configuration operates as follows. That is, the motor 200 is an electric motor such as a stepping motor, and rotates upon receiving electric power. The rotation of the motor 200 is transmitted to the ball screw part 220 by the coupling 222. The shaft portion 220a of the ball screw portion 220 converts the rotation of the motor 200 into a linear motion. The screw portion 220b moves in the x direction when the motor 200 rotates, for example, in the right direction, and moves in the −x direction when the rotation direction of the motor 200 is reversed. A bearing portion 230 integrated with the holder 240 is fixed to the screw portion 220, and the holder 240 moves together with the screw portion 220b.
As shown in FIG. 34, the holder 240 includes

holder wall portions

240a and 240c and a holder bottom portion 240b. As for the holder wall 240a, the surface facing the flow path switching mechanism 4 is formed on the inner surface 240aa, the rear surface of the inner surface 240aa is formed between the outer surface 240ab, and the inner surface 240aa and the outer surface 240ab. It is set as the engaging part 240ad engaged with. Further, a surface of the holder wall portion 240c that faces the flow path switching mechanism 4 is an inner surface 240ca, and a surface of the holder bottom portion 240b that faces the flow path switching mechanism 4 is an inner surface 240ba.

The bearing portion 230 and the holder 240 are moved in the ± x axis direction by the ball screw portion 220. In the sixth embodiment, moving in the x direction is hereinafter referred to as “forward”, and moving in the −x direction is hereinafter referred to as “backward”. When the screw portion 220b moves in the −x direction, the holder 240 moves backward, and when the screw portion 220b moves in the x direction, the holder 240 moves forward. At this time, since the holder wall 240a of the holder 240 is engaged with only the second member 20 of the flow path switching mechanism 4 at the engaging portion 240ad, the first member 46 is fixed when the holder 240 moves backward. The second member 20 moves backward while remaining. At this time, a force in the −x direction is applied to the second member 20 at a portion engaging with the holder wall 240a, and a force in the −x direction is also applied from the holder wall 240c. For this reason, in the sixth embodiment, the force applied by the ball screw portion 220 is efficiently transmitted to the second member 20, and the second member 20 is smoothly moved while maintaining the airtightness between the second member 20 and the first member 46. Can be moved to.
On the other hand, when the holder 240 advances, the second member 20 advances while the first member 46 is held. The advancement of the second member 20 can advance until it abuts against the holder wall 240c.

As described above, in the sixth embodiment, the relative positional relationship between the first member 46 and the second member 20 is changed by moving the second member 20 forward and backward relative to the first member 46. Due to the change in the relative position, the combination of connection between the first partial flow paths 52a to 52x of the first member 46 and the second

partial flow paths

22a, 22b, and 22c of the second member 20 changes. Thus, the configuration shown in FIG. 34 can switch the flow path formed in the flow path switching mechanism 4.
In the sixth embodiment, the individual drive unit 6 is not limited to the above configuration. For example, the individual driving unit 6 has one ball screw unit 220 and uses one place for adjusting the amount of movement of the holder 240. However, the individual drive unit 6 of the sixth embodiment may include a plurality of adjustment points for the movement amount of the holder 240 such as the ball screw unit 220, and the movement amount of the holder 240 may be changed in multiple stages.

35 (a), 35 (b), and 35 (c) are perspective views of the flow path switching mechanism holding and receiving portion 280 and the flow path switching mechanism 4 shown in FIG. In the sixth embodiment, the second member 20 is arranged in the y direction in the figure, and the first member 46 is combined with the plurality of second members 20. The flow path switching mechanism holding / receiving part 280 includes two members, a first holding / receiving part 280a and a second holding / receiving part 280b. The first holding receiving portion 280a includes a base portion 280aa that supports the first member 46, and a locking convex portion 280ab that is an engaging portion that is formed on the base portion 280aa and engages with the first member 46. . The second holding receiving portion 280b includes a base portion 280ba that supports the first member 46, and a locking projection 280bb that is an engaging portion that is formed on the base portion 280aa and engages with the first member 46. ing.

Furthermore, in the sixth embodiment, the spring is a length changing portion that changes the length in the arrangement direction (y direction) in which the base member 280aa and the first member of the base portion 280ba are arranged together with the base portion 280aa and the base portion 280ba. A member 250 is provided. The locking convex portion 280ab has an inclined portion 280ac that is inclined in the moving direction that moves in accordance with the length change by the spring member 250. The length of the base portion 280aa and the base portion 280ba is increased by the spring member 250. When it changes, the latching convex part 280ab enters between the base part 280aa and the first member 46. Further, the locking projection 280bb has an inclined portion 280bc that is inclined in the moving direction that moves in accordance with the length change by the spring member 250, and the length of the base portion 280aa and the base portion 280ba is increased by the spring member 250. When it changes, the latching convex part 280bb enters between the base part 280aa and the first member 46.

In the above description, in the sixth embodiment, since the flow path switching mechanism holding and receiving portion 280 is made of two members, the first holding and receiving portion 280a and the second holding and receiving portion 280b, the base portions 280aa and 280ba are also made of two members. ing. However, the base part of the sixth embodiment is not limited in the number of constituent members. The “length of the base portion” referred to in the sixth embodiment refers to the entire length of the base portions 280aa, 280b and the spring member 250 in the y direction. The lengths of the base portions 280aa and 280b and the spring member 250 are changed by changing the distance between the first holding receiving portion 280a and the second holding receiving portion 280b by expanding and contracting the spring member 250.
However, the sixth embodiment is not limited to the configuration in which the interval between the base portions 280aa and 280b is changed by the spring member 250. For example, when the base portion is composed of two members, the two members are configured to be slidable with each other, and one of them is slid on the other, and the length of the base portions 280aa and 280b is changed according to the amount of overlap. You may do it. Or you may comprise so that it can be bent so that a base part may become short by applying force toward the center from the both ends of the base part which consists of one member.

Next, the function of the flow path switching mechanism holding / receiving part 280 of the sixth embodiment will be specifically described. FIG. 35A is a diagram for explaining that the flow path switching mechanism 4 is attached to the flow path switching device 2. As shown in FIG. 35A, the flow path switching mechanism 4 is placed on the base part 280aa and the base part 280ba from above the flow path switching mechanism holding / receiving part 280. At this time, the flow path switching mechanism 4 is arranged such that the holder engaging portion 69 enters between the locking convex portions 280ab and 280bb. The flow path switching mechanism 4 is set on the holder 240 in a state of being placed on the flow path switching mechanism holding / receiving part 280 and attached to the flow path switching device 2.

FIG. 35B and FIG. 35C are diagrams for explaining that the flow path switching mechanism 4 is removed from the flow path switching device 2. At this time, in the sixth embodiment, in a state where the flow path switching mechanism 4 is placed on the flow path switching mechanism holding / receiving part 280, as shown in FIG. A force is applied so as to move in the direction of J, and at the same time, a force is applied so that the second holding receiver 280b moves in the direction of arrow K. The movement of the first holding receiving portion 280a and the second holding receiving portion 280b may be performed manually by the operator, or the first holding receiving portion 280a and the second holding receiving portion are connected to the flow path switching device 2. A mechanism for moving the portion 280b may be provided.
When the first holding receiving portion 280a and the second holding receiving portion 280b are moved in a direction facing each other, the holder engaging portion 69 is lifted along the inclined portions 280ac and 280bc inclined toward the moving direction, and is locked. The convex portions 280ab and 280bb exit from the lower concave portion 48b of the first member 46 and enter under the holder engaging portion 69. At this time, the holder engaging portion 69 rides on the locking convex portions 280ab and 280bb, and the flow path switching mechanism 4 is easily detached from the flow path switching mechanism holding / receiving portion 280.

Note that the flow path switching mechanism holding and receiving portion 280 of the sixth embodiment is not limited to the above-described configuration of the locking convex portions 280ab and 280bb, but enters the holder engaging portion 69 and uses the holder engaging portion 69 as a base. Any configuration may be used as long as it floats from the portions 280aa and 280ba. As such a configuration, for example, the inclined portion of the first holding receiving portion 280a is inclined opposite to the inclined portion 280ac and toward the opposite side of the second holding receiving portion 280b. The inclined portion is inclined toward the side opposite to the first holding receiving portion 280a. Then, the first holding receiver 280a and the second holding receiver 280b may be moved away from each other.
Further, in the sixth embodiment, instead of the locking projections 280ab and 280bb, for example, a folded leaf spring member is provided, and the holder engaging portion is moved by moving the first holding receiving portion 280a and the second holding receiving portion 280b. 69, the leaf spring member may be inserted in a folded state. If it does in this way, a leaf | plate spring member will open with the elastic force under the holder engaging part 69, and the holder engaging part 69 can be floated from base part 280aa and 280ba.

The flow path switching device described above can transfer a liquid to a target position while switching the flow path by pressurization by a gas supply mechanism, suction by a decompression mechanism, or a combination thereof. By combining at least one of the control mechanism, the stirring mechanism of the reaction vessel, and the radiation detection mechanism, a highly versatile radiopharmaceutical synthesis apparatus with a small amount of residual liquid in the flow path can be realized.

The present invention described above has the following idea.
<1> A flow path switching mechanism for switching a flow path for circulating a material used for chemical treatment, wherein the first member in which one or a plurality of first partial flow paths are formed and the first member in a movable state A second member having a plurality of or one second partial flow path combined with the member, and a driving force receiving portion for receiving a driving force for moving the second member in both directions of one axis, When the one member and the second member are combined, the first partial channel and the second partial channel communicate with each other to form a channel, and the combination of the first member and the second member As the second member moves in both directions of the one axis while maintaining, the combination of the first partial flow channel and the second partial flow channel communicating with each other is changed, so that the flow channel becomes another flow channel. A channel switching mechanism that can be switched.
<2> A plurality of the second members are arranged in one row direction and combined with the first member, and at least one of the flow paths includes the second partial flow paths of the plurality of second members. <1> a flow path switching mechanism formed in communication with each other via a partial flow path.
<3> The second partial flow path is orthogonal to the one axis, and the first partial flow path is at least one of two axes that communicate with the second partial flow path and are orthogonal to the one axis. <1> or <2> a flow path switching mechanism that forms a flow path along the line.
<4> The flow switching mechanism according to any one of <1> to <3>, wherein the driving force receiving portion includes a convex driving force receiving convex portion provided on the second member.
<5> The first member includes a pre-movement communication channel that is the first partial channel that communicates with the second partial channel when the second member is in a predetermined position, and the second member includes the second member Any one of <1> to <4>, including a post-movement communication channel that is the first partial channel that communicates with the second partial channel when moving along the axis from a predetermined position. One channel switching mechanism.
<6> The first member has a flow path convex portion having a convex shape around an end on the side toward the outside of the first partial flow path, and the flow path switching according to any one of <1> to <5> mechanism.
<7> At least a part of the first member is a frame, at least a part of the second member is fitted into the frame, and the frame includes a reference strain portion having a predetermined rigidity and the reference The flow path switching mechanism according to any one of claims 1 to 6, further comprising an easily strained portion having rigidity smaller than that of the strained portion.
<8> The flow path switching mechanism according to <7>, wherein at least a part of the easy strain portion is thinner than a thickness of the reference strain portion.
<9> A material supply unit including a flow path switching mechanism according to <6> and a material container having a bottom surface broken by the flow path convex portion of the flow path switching mechanism.
<10> The channel switching mechanism of <2> is held, an insertion groove into which the channel switching mechanism is inserted from at least one direction intersecting the row direction, and the channel switching inserted into the insertion groove The holder of the flow path switching mechanism which has the latching convex part which latches when a mechanism moves to the said row direction alternately.
<11><1> to <8> A drive unit that provides the drive force receiving unit with a drive force that moves the second member of any one of the flow path switching mechanisms in both directions of one axis, and the flow channel A flow path switching mechanism holding receiving portion for holding the first member of the switching mechanism, wherein the flow path switching mechanism holding receiving portion is the first member while the second member is stationary and moving by the driving portion. A flow path switching device that holds the liquid so as not to move.
<12> The flow path switching device according to <11>, wherein a plurality of the second members are attached, and the drive unit includes a plurality of individual drive units that individually drive the second members.
<13> At least a part of the plurality of second members is arranged in one direction, the first member is combined with the plurality of second members, and the flow path switching mechanism holding and receiving portion includes the first member. <11> or <12> a flow path switching device, comprising: a base portion to be supported; and an engagement portion that is formed on the base portion and engages with the first member.
<14> The base portion includes a length changing portion that changes a length in an arrangement direction in which the first member of the base portion is arranged.
The engaging portion formed on the base portion has an inclined portion that is inclined toward a moving direction that moves in accordance with a length change by the length changing portion, and the length changing portion causes the base portion to <113> The channel switching device according to <113>, wherein the engagement portion enters between the base portion and the first member when the length changes.
<15> A flow path switching mechanism installation body to which the flow path switching mechanism is attached is further provided, and the flow path switching mechanism installation body is integrated in a plurality of layers, and any one of <11> to <14> Channel switching device.
<16> The flow path switching device according to any one of <11> to <15>, wherein the material supply unit according to <9> is attached and used.
<17> The flow path switching device according to any one of <11> to <16>, further including a gas supply mechanism or a decompression mechanism.
<18> The flow path switching device according to any one of <11> to <17>, further comprising at least one of a reaction vessel, a temperature control mechanism for the reaction vessel, a stirring mechanism for the reaction vessel, and a radiation detection mechanism.
<19> A bottomed container for storing a material used for chemical treatment, the container main body for storing the material, and a bottom surface for sealing the inside of the container main body. Is a material container including at least a fragile portion that can be broken.
<20> The material according to <1>, wherein the bottom surface further includes a base portion that is more difficult to break than the weakened portion together with the weakened portion, and a connection portion that connects the inner peripheral surface of the container main body portion and the base portion. container.
<21> The material container according to <20>, wherein the fragile portion is formed of a thin film, and the base portion is formed of a thick film having a thickness larger than that of the fragile portion.
<22> The material container according to <20> or <21>, wherein the fragile portion is disposed on a radially outer side of the bottom surface than the base portion.
<23> The material container according to <21>, wherein the connection part is formed of the base part and the continuous thick film.
<24> The container main body and the bottom surface have a circular shape in a top view, and the inner diameter of the container main body is larger than the diameter of the bottom surface, according to any one of <19> to <23>. Material container.
<25> The container main body is provided with the bottom surface at one end in the axial direction perpendicular to the bottom surface, and has an opening at the other end, and the opening is parallel to the bottom surface. The material container according to any one of <19> to <24>, further comprising: a lid portion closed by the lid portion; and a lid fixing mechanism that fixes the lid portion to the container main body portion.
<26> The lid fixing mechanism includes a notch formed in the lid plate, an elastic piece connected to the container main body, and a notch width of the notch provided at the tip of the elastic piece. A locking member having a larger portion than the elastic piece, and the elastic piece is held in the notch and fixed to the outer surface of the lid plate by the locking member. 25> material container.
<27> The material container according to any one of <19> to <25>, a convex portion that breaks the fragile portion of the material container, and the convex portion within the convex portion, wherein the convex portion includes the fragile portion. A material supply unit comprising: a receiving member having a flow path that is broken and inserted into the bottom surface and communicates with the material container.
<28> The flow path switching mechanism according to any one of <1> to <8>, and a bottomed material container that contains a material used for chemical treatment, wherein the material container contains the material The material supply unit includes: a container main body portion that includes a bottom surface that seals the inside of the container main body portion; and the bottom surface includes at least a fragile portion that can be broken.
<29> The material according to <28>, wherein the bottom surface further includes a base part that is less likely to break than the weak part together with the weak part, and a connection part that connects the inner peripheral surface of the container main body part and the base part. Supply unit.
<30> The material supply unit according to <29>, wherein the fragile portion is formed of a thin film, and the base portion is formed of a thick film having a thickness larger than that of the fragile portion.
<31> The material supply unit according to <29> or <30>, wherein the fragile portion is disposed on a radially outer side of the bottom surface than the base portion.
<32> The material supply unit according to <30>, wherein the connection portion is formed of the base and the continuous thick film.
<33> The material supply unit according to any one of <28> to <32>, wherein the container body and the bottom have a circular shape in a top view, and an inner diameter of the container body is larger than a diameter of the bottom. .
<34> The container main body is provided with the bottom surface at one end in the axial direction perpendicular to the bottom surface, has an opening at the other end, and the opening is a lid plate parallel to the bottom surface. The material supply unit according to any one of <28> to <33>, further comprising: a lid portion closed by the lid portion; and a lid fixing mechanism that fixes the lid portion to the container main body portion.
<35> The lid fixing mechanism includes a notch formed in the lid plate, an elastic piece connected to the container main body, and a notch width of the notch provided at the tip of the elastic piece. A locking member having a larger portion than the elastic piece, and the elastic piece is held in the notch and fixed to the outer surface of the lid plate by the locking member. 34> material supply unit.
<36> The flow path switching mechanism includes a convex portion that breaks the fragile portion of the material container, and an inside of the convex portion, and the convex portion breaks the fragile portion and is inserted into the bottom surface. A material supply unit according to any one of <28> to <35>, comprising a receiving member having a flow path communicating with the material container in a state.
<37> A bottomed material container for storing a compound used in chemical treatment or a material used for synthesizing a drug, the container main body storing the material, and a bottom surface for sealing the inside of the container main body And the container main body portion has a first cylindrical portion having a cylindrical shape with a constant outer diameter and inner diameter, a second cylindrical portion having a constant outer diameter and inner diameter smaller than the first cylindrical portion, and A taper portion having an inclined surface connecting the first tube portion and the second tube portion; the bottom surface is a boundary between the taper portion and the second tube portion; and the taper of the second tube portion. The weak part which is formed between the lower end part on the opposite side to the part and breaks, the base part which is harder to break than the weak part, and the inner peripheral surface of the container body part and the base part A connection portion that is less likely to break, and the fragile portion is made of a thin film and is formed on the bottom surface. The base portion is formed of a thick film having a thickness larger than the thickness of the fragile portion, and the connection portion is formed of the thick film continuous with the base portion. Material container.
<38> A bottomed material container for storing a compound by chemical treatment or a material used for synthesizing a drug, and a bottom surface for sealing the inside of the container main body for storing the material And the bottom surface includes at least a fragile portion that can be broken, and the container body portion is provided with the bottom surface at one end in an axial direction perpendicular to the bottom surface, and the other end. A lid part that has an opening in the part and closes the opening by a lid plate parallel to the bottom surface, and a lid fixing mechanism that fixes the lid part to the container body part, the lid fixing mechanism includes: A locking member having a notch formed in the lid plate, an elastic piece connected to the container main body, and a portion larger than the notch width of the notch provided at the tip of the elastic piece. And when the elastic piece is held in the notch Both are fixed to the outer surface of the said cover plate by the said locking member, and the material container fixed.

This application includes Japanese Patent Application No. 2017-90748, Japanese Application No. 2017-90749 filed on April 28, 2017, and Japanese Application No. 2018-016544 filed on February 1, 2018. Claiming the priority based on, and incorporate all of its disclosure here.

Claims

A flow path switching mechanism for switching a flow path through which a material used for chemical processing is circulated,
A first member formed with one or more first partial flow paths;
A second member combined with the first member in a movable state and having a plurality of or one second partial flow path;
A driving force receiving portion for receiving a driving force for moving the second member in both directions of one axis;
By combining the first member and the second member, the first partial channel and the second partial channel communicate with each other to form a channel, and the first member and the second member When the second member moves in both directions of the one axis while maintaining the combination, the combination of the first partial flow path and the second partial flow path communicating with each other is changed, and the flow path is changed to another flow. A flow path switching mechanism that can be switched to a road.
A plurality of the second members are arranged in one row direction and combined with the first member, and at least one of the flow paths is configured such that the second partial flow paths of the plurality of second members are the first partial flow paths. The flow path switching mechanism according to claim 1, wherein the flow path switching mechanism is formed in communication with each other.
The second partial flow path is orthogonal to the one axis, and the first partial flow path is a flow along at least one of two axes that communicate with the second partial flow path and are orthogonal to the one axis. The flow path switching mechanism according to claim 1 or 2, wherein a flow path is formed.
The flow path switching mechanism according to any one of claims 1 to 3, wherein the driving force receiving portion includes a convex driving force receiving convex portion provided on the second member.
The first member includes a pre-movement communication channel that is the first partial channel that communicates with the second partial channel when the second member is in a predetermined position, and the second member is in the predetermined position. 5. The flow according to claim 1, further comprising a post-movement communication channel that is the first partial channel that communicates with the second partial channel when moving along the axis. Road switching mechanism.
The flow path switching mechanism according to any one of claims 1 to 5, wherein the first member has a flow path convex portion having a convex shape around an end portion on the side facing the outside of the first partial flow path.
At least a part of the first member is a frame, and at least a part of the second member is fitted into the frame. The frame includes a reference strain part having a predetermined rigidity, and a reference strain part. The flow path switching mechanism according to any one of claims 1 to 6, further comprising an easily strained portion having a small rigidity.
7. A material supply unit comprising the flow path switching mechanism according to claim 6 and a material container having a bottom surface that is broken by the flow path convex portion of the flow path switching mechanism.
A bottomed material container that contains material used for chemical processing,
The material container which has a container main-body part which accommodates the said material, and the bottom face which seals the inside of the said container main-body part, and the said bottom face includes the fragile part which can be fractured at least in part.
The material container according to claim 9, wherein the container body and the bottom have a circular shape in a top view, and an inner diameter of the container body is larger than a diameter of the bottom.
The container body is provided with the bottom surface at one end in the axial direction perpendicular to the bottom surface, and has an opening at the other end, and the opening is closed by a lid plate parallel to the bottom surface. The material container according to claim 9 or 10, further comprising a portion and a lid fixing mechanism that fixes the lid to the container main body.
An insertion groove that holds the flow path switching mechanism according to claim 2 and into which the flow path switching mechanism is inserted from at least one direction that intersects the row direction, and the flow path switching mechanism that is inserted into the insertion groove. The holder of the flow path switching mechanism which has the latching convex part which latches by moving to the said column direction alternately.
A driving unit that applies a driving force to the driving force receiving unit to move the second member of the flow path switching mechanism according to any one of claims 1 to 7 in both directions of one axis;
A flow path switching mechanism holding receiver for holding the first member of the flow path switching mechanism;
With
The flow path switching mechanism holding receiver holds the second member so that the first member does not move while the second member is stationary and moved by the driving unit.
The flow path switching device according to claim 13, wherein a plurality of the second members are attached, and the driving unit includes a plurality of individual driving units that individually drive the second members.
At least some of the plurality of second members are arranged in one direction, the first member is combined with the plurality of second members,
15. The flow path switching mechanism holding and receiving part includes a base part that supports the first member, and an engaging part that is formed on the base part and engages with the first member. Channel switching device.
The flow path according to any one of claims 13 to 15, further comprising a flow path switching mechanism installation body to which the flow path switching mechanism is attached, wherein a plurality of the flow path switching mechanism installation bodies are integrated. Switching device.
The flow path switching device according to claim 13, wherein the material supply unit according to claim 8 is attached and used.
The flow path switching device according to any one of claims 13 to 17, further comprising a gas supply mechanism or a decompression mechanism.