JPWO2018199266A1 - Flow path switching mechanism, material supply unit, material container, flow path switching mechanism holder, and flow path switching device - Google Patents

Abstract

A first member (10) having one or a plurality of first partial flow paths (12a, 12b, 12d) formed therein, and a plurality of or one second partial flow path combined with the first member (10) in a movable state. The second member (20) having (22a, 22b, 22c) constitutes a flow path switching mechanism. At this time, the driving force receiving convex portion (27) for receiving the driving force for moving the second member (20) in both directions of the x-axis, the first member (10) and the second member (20) are combined to form a first member. One of the partial flow paths (12a, 12b, 12d) and any of the second partial flow paths (22a, 22b, 22c) communicate with each other to form a flow path, and the first member (10) and the second member (20) ), the second member (20) moves in both directions of the x-axis to communicate with any one of the first partial flow paths (12a, 12b, 12d) and the second partial flow path (22a, 22b, 22c) is changed so that the flow path is switched to another flow path.

Description

The present invention relates to a flow path switching mechanism for switching a flow path of a material of a fluid used for chemical processing, a material supply unit, a holder of the flow path switching mechanism, and a flow path switching device.

In an apparatus for synthesizing a drug by a chemical treatment, there are cases where one material is used in a plurality of synthesizing steps by switching the flow path of a material or the like used for synthesizing the drug.
Known fluid control mechanisms for switching flow paths include those described in Patent Documents 1 and 2, for example.
Patent Literature 1 describes a drug manufacturing system. The chemical|medical agent manufacturing system of patent document 1 switches the flow path of a three-way stopcock by rotating a three-way stopcock holder with a three-way stopcock attached by the action of a motor. Further, the apparatus for producing an organic compound described in Patent Document 2 has a configuration in which three-way active holders are mounted in different steps.

JP, 2010-270068, A JP, 2014-201571, A

The three-way stopcocks described in Patent Document 1 and Patent Document 2 described above always have three flow paths secured, and opening and closing this ensures the other flow paths while using one flow path. Space will be required. However, there are some areas of drug synthesis, such as the synthesis of radiopharmaceuticals, where the synthesis is carried out using very small amounts of material. For the synthesis of radiopharmaceuticals, very small amounts of liquid material, such as 100 μl, are used. When the flow path through which such a liquid material flows is switched by using a known three-way stopcock, the amount of the liquid material remaining in the empty space increases and the ratio of the remaining amount to the used amount increases.
The present invention has been made in view of the above points, and a switching mechanism with a small amount of remaining material, a material supply unit using this switching mechanism, a material container, a holder of a flow path switching mechanism, a flow path switching device, and Provide a material container.

One aspect of a flow channel switching mechanism of the present invention is a flow channel switching mechanism that switches a flow channel through which a material used for chemical treatment is circulated, and a first member in which one or more first partial flow channels are formed. , A second member which is movably combined with the first member and has a plurality of or one second partial flow paths, and a driving force reception which receives a driving force for moving the second member in both directions of one axis. The first member and the second member are combined to form a flow path in which the first partial flow path and the second partial flow path communicate with each other, and the first member By moving the second member in both directions of the one axis while maintaining the combination of the second member and the second member, the combination of the first partial flow channel and the second partial flow channel communicating with each other is changed. The flow path is switched to another flow path.

One aspect of the material supply unit of the present invention includes a material container having a bottom surface that is broken by the flow path protrusion of the flow path switching mechanism.
In addition, the material container of the present invention is a bottomed material container that contains a material used for chemical processing, and a container body that contains the material, and a bottom surface that seals the inside of the container body. , And the bottom surface includes a fragile fragile portion at least in part.

One aspect of the holder of the flow path switching mechanism of the present invention is an insertion groove that holds the flow path switching mechanism, and in which the flow path switching mechanism is inserted from at least one direction intersecting the row direction, and the insertion groove. The flow path switching mechanism inserted into the groove alternately has locking projections that are locked by moving in the row direction.
One aspect of a flow path switching device of the present invention is a drive section that gives a drive force to the drive force receiving section for moving a second member of the flow path switching mechanism in both directions of an axis, and the flow path switching apparatus. A flow path switching mechanism holding receiver for holding the first member of the mechanism, wherein the flow path switching mechanism holding receiver is configured such that the first member is in motion while the second member is stationary and while the second member is moving. Hold it so it doesn't move.

INDUSTRIAL APPLICABILITY The present invention can provide a switching mechanism with a small amount of remaining material in a flow path, a material supply unit using this switching mechanism, a material container, a holder of the flow path switching mechanism, and a flow path switching device.

It is a figure for demonstrating the flow-path switching mechanism of 1st embodiment. It is a top view, a front view, and a side view of the first member shown in FIG. It is a top view, a front view, and a side view of the second member shown in FIG. It is a figure for demonstrating switching of the flow path of 1st embodiment of this invention. It is a figure for illustrating the member which transmits the driving force of the side which pushes and pulls the driving force receiving convex part of a first embodiment. It is a perspective view of a flow path switching mechanism of a second embodiment of the present invention. FIG. 7 is an exploded perspective view of the flow path switching mechanism shown in FIG. 6. FIG. 7 is a perspective view of a first member of the flow path switching mechanism shown in FIG. 6. FIG. 7 is a top view, a front view, and a sectional view of the flow path switching mechanism shown in FIG. 6. It is a perspective view of the material supply unit of 2nd embodiment of this invention. It is a perspective view of the material container shown in FIG. It is sectional drawing which expands and shows a part of container main body shown in FIG. FIG. 13 is an enlarged view of the bottom surface shown in FIGS. 11 and 12. It is a figure for demonstrating the process in which the bottom face shown in FIGS. It is a figure for demonstrating the holder of 2nd embodiment of this invention. It is a perspective view for explaining the material supply unit of a third embodiment of the present invention. It is the material container shown in FIG. 16, Comprising: It is a perspective view which shows the state which the lid part closed the opening part. It is the material container shown in FIG. 16, Comprising: It is a perspective view which shows the state which the lid part opened the opening part. It is the top view which looked at the material container shown in FIG. 18 from the direction of arrow IV. It is the bottom view which looked at the material container shown in FIG. 18 from the arrow V direction. It is sectional drawing which follows the arrow line VI of the material container shown in FIG. FIG. 22 is an enlarged view of a range surrounded by a broken line VII of the container body shown in FIG. 21. It is the enlarged view which looked at the bottom face shown in FIG. 22 from the direction of the arrow V in FIG. It is a figure for demonstrating the lid fixing mechanism of 3rd Embodiment of this invention. It is a perspective view of a channel switching mechanism of a fourth embodiment of the present invention. FIG. 26 is an exploded perspective view of the flow path switching mechanism shown in FIG. 25. It is a figure which shows the trace amount sampling system which used the flow-path switching mechanism of 4th embodiment of this invention. FIG. 28 is a diagram for explaining a fluid flowing through a flow path switching mechanism in the trace amount sampling system shown in FIG. 27. (A) is a perspective view of the 1st member of 5th embodiment, (b) is a perspective view of a 2nd member. It is the figure which showed the flow-path switching system containing the flow-path switching apparatus of 6th embodiment of this invention. It is a figure for demonstrating the inside of the flow-path switching mechanism holding unit shown in FIG. FIG. 31 is an exploded perspective view for explaining a flow channel switching mechanism attached to the flow channel switching mechanism holding unit shown in FIG. 30. It is a figure for demonstrating the flow path of the 1st member of FIG. FIG. 32 is a schematic diagram for explaining the individual drive unit shown in FIG. 31. (A), (b), (c) is a perspective view of the flow path switching mechanism holding part and flow path switching mechanism shown in FIG. 34.

Hereinafter, first to fifth embodiments of the present invention will be described with reference to the drawings. In all the drawings, the same constituents will be referred to with the same signs, while omitting their overlapping descriptions. Further, in the embodiments described below, in the flow path switching mechanism, the material supply unit, the holder, and the flow path switching device, the side where the flow path switching mechanism is provided with the holder engaging portion 15 (FIG. 1) is down, and vice versa. Side up. Such a vertical direction is determined independently of the gravity direction.
Further, FIGS. 1 to 26 shown in the embodiments described below show configurations of a flow path switching mechanism, a material supply unit using this flow path switching mechanism, a holder of the flow path switching mechanism, and a flow path switching device. This is for the purpose of explaining the positional relationship, and does not necessarily indicate the length, thickness, width, etc. of each member accurately.

[First embodiment]
(Flow path switching mechanism)
Hereinafter, the flow path switching mechanism of the first embodiment of the present invention will be described. The flow path switching mechanism of the first embodiment is a mechanism that switches the flow path through which the material used for the chemical treatment flows. In the first embodiment, the “chemical treatment” includes, in addition to synthetic treatment using a known organic chemical reaction, reaction, conversion, ionization, separation (purification), hydrolysis, recovery of individual substances performed for this treatment. And processing such as extraction.
FIG. 1A, FIG. 1B and FIG. 1C are views for explaining the flow path switching mechanism of the first embodiment. FIG. 1A is a perspective view for explaining the flow path switching mechanism of the first embodiment, which is configured in combination. 1B shows the first member 10, and FIG. 1C shows the second member 20.

As shown in FIG. 1B, the first member 10 includes a main body 14. The main body 14 is a frame body having a predetermined thickness, and in FIGS. 1A to 1C, the surface of the frame body facing the z direction of the x, y, z coordinates shown in the drawing is an upper surface. A surface facing 11a and the −z direction is a lower surface 11c. In addition, in this specification, of the axes of x, y, and z coordinates, only the +x direction, the +y direction, and the +z direction are illustrated, but the directions opposite to the directions indicated by the arrows of the respective axes are −. It indicates the x direction, the -y direction, and the -z direction.
The body 14 of the first member 10 is provided with a holder engaging portion 15. Further, in the first embodiment, the surfaces facing the y direction and the −y direction are side surfaces. Further, in the first embodiment, the surface facing the x direction is the back surface 11f, the surface facing the −x direction is the front surface 11e, and the hollow portion 16 is formed between the back surface 11f and the front surface 11e. Therefore, the back surface 11f and the front surface 11e each have a frame shape. Each of the upper surface 11a, the lower surface 11c, the side surfaces 11b and 11d, and the back surface 11f is an outer surface, and a surface corresponding to the back surface of the outer surface in each surface is referred to as an “inner surface”.

The above-mentioned first member 10 has a flow passage convex portion having a convex shape around the end portion of the first partial flow passages 12a, 12b, 12d on the side toward the outside. In the first embodiment, the flow passage projections 13a, 13b, 13d are provided on the upper surface 11a and the side surfaces 11b, 11d of the main body 14, respectively.
The flow path protrusions 13 a, 13 b, 13 d have a function of connecting a container containing a liquid containing a material to the flow path switching mechanism 1. In addition, the flow path protrusions 13 a, 13 b, and 13 d have a function of connecting a tube (not shown) to the flow path switching mechanism 1. With such a configuration, it is possible to introduce the liquid containing the material or the like from the tube or the fluid of the gas that regulates the moving direction of the material into the flow path switching mechanism 1 and to flow out from the flow path switching mechanism 1.
Here, the “material” includes a substance, a drug (reagent), a catalyst, water and the like used for synthesizing a drug. The material and the like are words including such a material and a gas such as an inert gas for promoting the flow of the material. When the flow path switching mechanism 1 is used for synthesizing a radioactive compound or a radiopharmaceutical (including macromolecules or antibodies labeled with radionuclides, hereinafter also collectively referred to as “radioactive agents, etc.”), the material is , Synthetic materials such as these radiopharmaceuticals are housed. Examples of materials for synthesizing radiopharmaceuticals include substances (label precursors) used for synthesizing radiopharmaceuticals, drugs (reagents), catalysts, water and the like.

One or more first partial flow paths are formed in the first member 10. In the first embodiment, the first member 10 is formed with three first partial flow paths 12a, 12b, 12d. The first partial flow path 12a is a flow path having an opening 12ab on the inner surface of the upper surface 11a and an opening 12aa at the tip of the flow path protrusion 13a. The first partial flow path 12b is a flow path having an opening 12bb on the inner surface of the side surface 11b and an opening 12ba at the tip of the flow path protrusion 13b. The first partial flow path 12d is a flow path having an opening 12da on the inner surface of the side surface 11d and an opening 12db at the tip of the flow path protrusion 13d.

The second member 20 is combined with the first member 10 in a state of being movable in both directions of the x axis (x direction and −x direction) with respect to the first member 10, and has a plurality of or one second partial flow paths. doing. That is, the second member 20 faces the upper surface 21a facing the z direction, the lower surface 21c facing the -z direction, the side surface 21b facing the -y direction, the side surface 21d facing the y direction, the back surface 21f facing the x direction, and the -x direction. It has a front surface 21e. Such a second member 20 has a main body 24 having a rectangular parallelepiped appearance. The second member 20 has a small-diameter second partial flow path communicating with the outside inside the main body 24.

In the first embodiment, the second member 20 has three second partial flow paths 22a, 22b, 22c. The second partial flow path 22a is a flow path having an opening 22aa on the upper surface 21a and an opening 22ab on the side surface 21d. Such a second partial flow path 22a has a shape in which the "L" shape is horizontally inverted when viewed from the front. The second partial flow path 22b is a flow path having an opening 21ba on the side surface 21b and an opening 22cb on the side surface 21d. Such a second partial flow path 22b has a linear shape along the y axis when viewed from the front. The second partial flow path 22c is a flow path having an opening 22ca on the upper surface 21a and an opening 22cb on the side surface 21b. Such a second partial flow path 22c has an "L" shape in a front view.

In addition, the second member 20 of the first embodiment includes a driving force receiving portion that receives a driving force that moves the second member 20 in both directions of the x axis. The driving force receiving portion of the first embodiment is the driving force receiving convex portion 27 provided on the front surface 21e and having a convex shape. In the first embodiment, one axis is the x axis in the drawing, and the driving force receiving convex portion 27 is a member that moves the second member 20 in the x direction and the −x direction. The configuration of the driving force receiving convex portion 27 will be described in detail later.

By combining the first member 10 and the second member 20, the first partial flow path and the second partial flow path communicate with each other to form a flow path. Here, the flow path is a path through which the fluid that has entered the one flow path switching mechanism 1 flows out of the flow path switching mechanism 1, and the first or second partial flow path is such a flow path. Refers to the part of the road. The combination of the first member 10 and the second member 20 is performed by inserting the second member 20 into the hollow portion 16 of the first member 10. In the first embodiment, when the second member 20 is inserted into the hollow portion 16 of the first member 10, the inner surface of the first member 10 and the upper surface 21a, the side surfaces 21b, 21d, and the lower surface 21c of the second member 20 are appropriate. The sizes and materials of the first member 10 and the second member 20 are designed so that the second member 20 moves smoothly in the hollow portion 16 and stably stops while contacting with each other with great friction.
Then, in the flow path switching mechanism 1 of the first embodiment, the second member 20 moves in the x-axis direction while maintaining the combination of the first member 10 and the second member 20, thereby communicating the first partial flow path. The combination of the second partial flow path and the second partial flow path is changed to switch the flow path to another flow path. It should be noted that “switching the flow path” includes changing the starting end and the terminating end of the flow path and changing the path between the starting end and the terminating end.

Hereinafter, the above configuration will be described in detail.
(Switch of flow path)
2, 3 and 4 are diagrams for explaining the switching of the flow paths of the first embodiment. 2A is a top view of the first member 10, FIG. 2B is a front view of the first member 10, and FIG. 2C is a side view of the first member 10. 3A is a top view of the second member 20, FIG. 3B is a front view of the second member 20, and FIG. 3C is a side view of the second member 20. FIG. 4A is a top view of the flow path switching mechanism 1 when the second member 20 is at the position P1. FIG. 4B is a top view of the flow path switching mechanism 1 when the second member 20 is at the position P2, and FIG. 4C is a flow path switching mechanism 1 when the second member 20 is at the position P3. FIG. In the first embodiment, the position P1, the position P2, and the position P3 are all represented as the position of the front surface 21e with the front surface 11e of the first member 10 being the reference position P0. As is apparent from FIGS. 4A, 4B, and 4C, the second member 20 is pushed into the first member 10 in the order of position P1, position P2, and position P3. Have moved to.

As shown in FIG. 2A, the first member 10 has a first partial flow path 12b and a first partial flow path 12d formed in a straight line, and the openings 12bb and 12da of both are connected to the hollow portion 16. ing. At this time, when the second member 20 shown in FIG. 3A moves to the position P1 shown in FIG. 4A, the opening 12da (see FIG. 2A) of the first partial flow path 12d and the second partial flow. The opening 22ab of the passage 22a is connected, and the opening 22aa of the second partial flow passage 22a and the opening 12ab of the first partial flow passage 12a (see FIG. 2C) are connected to form a flow passage. .. In the first embodiment, such a flow path is hereinafter referred to as “flow path 12d-22a-12a”. In the flow paths 12d, 22a, 12a, the openings 12db to 12aa communicate with each other, and a fluid can flow between them.

Moreover, when the second member 20 moves to the position P2 shown in FIG. 4B, the opening 12da of the first partial flow path 12d (see FIG. 2A) and the opening 22bb of the second partial flow path 22b are separated from each other. The opening 22ba of the second partial flow path 22b and the opening 12bb of the first partial flow path 12b (see FIG. 2C) are connected to form a flow path. Hereinafter, this flow path will be referred to as "flow path 12d-22b-12b". In the flow paths 12d-22b-12b, the openings 12da to 12ba are in communication with each other, and a fluid can flow between them.
Further, when the second member 20 moves to the position P3 shown in FIG. 4C, the opening 12bb of the first partial flow passage 12b (see FIG. 2C) and the opening 22cb of the second partial flow passage 22c (see FIG. 3(c)), and the opening 22aa of the second partial flow path 22b and the opening 12ab of the first partial flow path 12a (see FIG. 2(c)) are connected to form a flow path. .. Hereinafter, such a flow channel will be referred to as "flow channel 12b-22c-12a". In the flow paths 12b-22c-12a, the openings 12ba to 12aa communicate with each other, and a fluid can flow between them.

As described above, in the flow path switching mechanism 1 of the first embodiment, the second partial flow path is orthogonal to the one axis (x-axis), and the first partial flow path communicates with the second partial flow path and is x. A flow path is formed along at least one of two axes (y axis and z axis) orthogonal to the axis.
Specifically, each of the second partial flow paths 22a, 22b, 22c is orthogonal to the x axis, which is one axis. Here, “orthogonal” includes not only the intersection of the coordinate axes in FIG. 1 on the xy plane but also the intersection on the xz plane.
For example, the second partial flow path 22a is orthogonal to the x axis on the xy plane from the opening 22ab to a portion where the angle changes by 90 degrees, and from this portion to the opening 22aa on the x axis and the xz plane. They are orthogonal. Further, in the second partial flow path 22b, the entire opening 22ba to the opening 22bb are orthogonal to the x axis on the xy plane. Further, the second partial flow path 22c is orthogonal to the x axis on the xy plane from the opening 22cb to a portion where the angle changes by 90 degrees, and from this portion to the opening 22ca on the x axis and the xz plane. They are orthogonal.

According to the configuration of the first embodiment as described above, the residual amount of the liquid material in the portion where the angle of the flow channel changes is reduced, and the liquid material is promptly removed from the inner surface of the flow channel by an inert gas or the like. be able to.
However, the above configuration is an example of the first embodiment, and the first embodiment is not limited to such a configuration. In the first embodiment, for example, the first partial flow path and the second partial flow path may be bent at an angle other than 90 degrees. Further, the first partial flow path and the second partial flow path may be paths that allow the openings at both ends to communicate with each other obliquely without bending.

(Drive force receiving convex part)
The driving force receiving convex portion 27 of the above-described first embodiment is a plate member 10 including a peripheral surface having a curved surface portion 27a and a flat surface portion 27b. As shown in FIGS. 3A to 3C, the driving force receiving convex portion 27 is fixed to the front surface 21e of the second member 20 via the support portion 23. The driving force receiving convex portion 27 of the first embodiment is engaged with a member that transmits a driving force such as a motor, and pushes or pulls the second member 20 to push or pull the second member 20 in the x-axis direction. The driving force in the direction is accepted.
FIG. 5A and FIG. 5B are views for illustrating a member that transmits the driving force on the side that pushes and pulls the driving force receiving convex portion 27 of the first embodiment. The members 51 and 53 for transmitting the driving force shown in FIGS. 5A and 5B engage with the driving force receiving convex portion 27 and push and pull the driving force receiving convex portion 27 along the x-axis. This is a configuration for transmitting the driving force to be applied. The members 51 and 53 are different in that the member 51 is integrally molded, whereas the member 53 is formed by two parts. In the first embodiment, an actuator such as a motor, a solenoid, or a cylinder may be used as a drive source of the driving force, or the second member 20 may be manually moved using the operator's muscle as a chemical actuator. Good.

The member 51 shown in FIG. 5A includes a peripheral surface 51d that is a curved surface, and side surfaces 51g and 51f that are provided perpendicular to the peripheral surface 51d and a surface 51e that is perpendicular to both the side surfaces 51g and 51f. .. The member 51 is formed with an engaging portion 51a that engages with the driving force receiving convex portion 27, and the member 51 accommodates the driving force receiving convex portion 27 in the direction of arrow A in the member 51a. The driving force receiving convex portion 27 is designed such that its length in the z-axis direction corresponds to the interval between the upper end 51b and the lower end 51c of the engaging portion 51a, and is fitted to the engaging portion 51a. With such a configuration, the driving force receiving convex portion 27 does not come off from the engaging portion 51a even if a force along the x-axis is applied after being fitted to the engaging portion 51a.
Further, the member 53 shown in FIG. 5B has a peripheral surface 53d including three planes, side surfaces 53g and 53f provided perpendicular to the peripheral surface 53d, and a surface 53e perpendicular to both the side surfaces 53g and 53f. I have it. The member 53 is formed with an engagement portion 53a that engages with the driving force receiving convex portion 27, and the member 53 accommodates the driving force receiving convex portion 27 in the direction of arrow A in the member 53. The driving force receiving convex portion 27 is designed so that its length in the z-axis direction corresponds to the interval between the upper end 53b and the lower end 53c of the engaging portion 53a, and is fitted to the engaging portion 53a. With such a configuration, the driving force receiving convex portion 27 does not come off from the engaging portion 53a even if a force along the x-axis is applied after being fitted to the engaging portion 53a.

However, the driving force receiving portion of the first embodiment is not limited to the one having the convex shape as described above, and if it engages with the member that transmits the driving force, the driving force receiving portion may be formed according to the shape of this member. It may have a concave shape or any other shape. At this time, the members 51 and 53 may have any shape corresponding to the driving force receiving portion.
Further, the first embodiment is not limited to the one in which the driving force receiving portion receives the push pull driving force. For example, the driving force in the pressing direction may be alternately applied to the front surface 21e and the back surface 21f of the second member 20 to move the second member 20 along the x axis. In such a case, the driving force receiving portion is the front surface 21e and the back surface 21f. That is, the driving force receiving portion may be a flat surface.

The flow path switching mechanism 1 described above is entirely formed by resin integral molding. Any resin can be used as the material of the flow path switching mechanism 1 as long as it satisfies the requirements of the flow path switching mechanism 1 such as thermoplasticity, rigidity, elasticity, transparency, solvent resistance, and cost. May be As a resin satisfying such a condition, for example, polyethylene terephthalate (Poly Ethylene Terephthalate), thermopolyolefin (Thermo Poly Olefin), polypropylene (Poly Propylene) and the like are considered.
However, the first embodiment is not limited to forming the flow path switching mechanism 1 by integral molding with resin. The flow path switching mechanism 1 may use a material other than resin, such as metal, for all or part of the flow path switching mechanism 1.

The flow path switching mechanism 1 of the first embodiment described above can switch the flow path of the fluid by moving the second member 20 along one axis. For this reason, the space required for the switching operation of the flow paths can be made smaller than the structure in which the flow paths are switched by rotating the parts such as a rotary type three-way stopcock. In addition, the flow path switching mechanism 1 of the first embodiment that forms flow paths as needed is advantageous in reducing the dead space in parts compared to a three-way stopcock or the like in which three flow paths are always formed. .. Further, the flow path switching mechanism 1 of the first embodiment has only a necessary flow path formed when needed, so that the component structure is simplified as compared with the case where a plurality of flow paths are selectively opened and closed by other members. It is advantageous to For this reason, it is possible to provide a flow path switching mechanism that is suitable for a process in which the diameter of the flow path is made smaller than that of a known configuration, the remaining amount of material is reduced, and a small amount of material is used.

Next, the flow path switching mechanism, material supply unit and holder of the second embodiment will be described.
[Second embodiment]
(Flow path switching mechanism)
6, FIG. 7, FIG. 8, FIG. 14(a), FIG. 14(b) and FIG. 14(c) are views for explaining the flow path switching mechanism 3 of the second embodiment. 6 is a perspective view of the flow path switching mechanism 3, and FIG. 7 is an exploded perspective view in which the first member 60 and the second member 20 of FIG. 6 are disassembled. FIG. 8 is a diagram for explaining the flow path of the first member 60 of FIG. 7, FIG. 14( a) is a top view of the first member 60, and FIG. 14( b) is a front view of the first member 60. 14C is a cross-sectional view of the first member 60 taken along line 9c-9c.

As shown in FIGS. 6 to 8, in the flow path switching mechanism 3, a plurality of second members 20 are arranged in one row direction (y-axis direction shown in the drawing) and combined with the first member 60. .. At least one of the flow paths of the flow path switching mechanism 3 is formed by connecting the second partial flow paths of the plurality of second members 20 via the first partial flow path.
In the second embodiment, the y-axis shown in FIG. 6 is the column direction of the second members 20. The first member 60 has an upper surface 61a, side surfaces 61b and 61d, a lower surface 61c, a front surface 61e and a back surface 61f. A hollow portion 66 (FIGS. 8 and 9) is formed in the first member 60, and the front surface 61e and the back surface 61f have a frame shape corresponding to the plurality of hollow portions 66. Flow passage protrusions 63a are formed on the upper surface 61a, and flow passage protrusions 63b and 63d are formed on the side surfaces 61b and 61d, respectively. Further, a holder engaging portion 65 is formed on the lower surface 61c.

As shown in FIGS. 6 to 9, the first member 60 has a main body 64. In the main body 64, the first partial flow paths 62a, 62b, 62c, 62d, 62e, 62f, 62g, 63h, 62i, 62j, 62k, 62o, 62p, 62q, 62r, 62s, 62t, 62u, 62v, 62w, 62x, 62y is formed, and the first partial flow paths 62a to 62y each communicate with the hollow portion 66. The hollow portion 66 is formed with openings 62ab to 62jb, openings (not shown) opened to face the openings 62ab to 62jb, and openings (not shown) of the first partial flow paths 62o to 62y. (See FIG. 8).
Further, in the second embodiment, as in the first embodiment, the second member 20 is inserted into the hollow portion 66, and the first partial flow passage and the second partial flow passage of the second member 20 inside the hollow portion 66 are formed. A channel is formed in communication with each other. In such a flow path switching mechanism 3, the second partial flow paths of the plurality of second members 20 can be connected to each other via the first partial flow path to form a flow path.

For example, FIG. 4 shows the second member 20 (referred to as “second member 20A” for convenience of description) inserted between the first partial flow passage 62b and the first partial flow passage 62c in FIGS. 7 and 8. Move to position P1. Further, the second member 20 (referred to as "second member 20B") inserted between the first partial flow path 62c and the first partial flow path 62d is moved to the position P2 shown in FIG. The second member 20 (hereinafter referred to as "second member 20C") inserted between 62d and the first partial flow path 62e is moved to the position P3 shown in FIG. At this time, channels 62p-22a-62c-22b-62d-12c-62r are formed in the channel switching mechanism 3. When the liquid is passed through this flow path, the fluid that has flowed into the second member 20A from the first partial flow path 62p is passed through the second partial flow path 22b of the second member 20B to the second partial flow path 22c of the second member 20C. It can be made to flow out through the partial flow path 62r.
Further, for example, when all the second members 20 of the flow path switching mechanism 3 are moved to the position P2 shown in FIG. 4, the flow path switching mechanism 3 includes the first partial flow path 62a to the first partial flow path 62y. A flow path that communicates in a straight line is formed. Further, by connecting the flow path convex portions 63a to each other, the fluid can be circulated and stirred in the flow path switching mechanism 3.
From the above, in the second embodiment, the second partial flow paths 22a, 22b, 22c can be arbitrarily connected between the plurality of second members 20. In the second embodiment as described above, the degree of freedom in designing the flow path is increased more than in the first embodiment, and the movement of the fluid in the synthesizing device can be arbitrarily controlled.

(Material supply unit)
FIG. 10 is a diagram for explaining the material supply unit 100 of the second embodiment. The material supply unit 100 includes the flow path switching mechanism 3 of the second embodiment and the material container 80. The material container 80 includes the material container 80 having a bottom surface 83 (see FIGS. 11 to 13) that is broken by the flow passage protrusion 63a (see FIGS. 6 to 9) of the flow passage switching mechanism 3. In 90 shown in FIG. 10, the bottom surface 83 is inserted into the flow passage convex portion 63a of the flow passage switching mechanism 3, and the internal material is supplied from the flow passage convex portion 63a to the flow passage switching mechanism 3.
FIG. 11 is a perspective view of the material container 80 shown in FIG. FIG. 12 is a sectional view taken along the arrow line XII. FIG. 13 is an enlarged view of the bottom surface 83 shown in FIGS.
The material container 80 includes a container body 90 that is a container body portion that is long in the vertical direction. The container body 90 connects a tubular portion 87 having a tubular shape with a constant outer diameter and an inner diameter, a tubular portion 89 having a constant outer diameter and an inner diameter smaller than the tubular portion 87, and the tubular portion 87 and the tubular portion 89. And a tapered portion 88 having an inclined surface. A bottom surface 83 is provided between the boundary between the tapered portion 88 and the tubular portion 89 and the lower end 79 of the tubular portion 89.

Further, the material container 80 is provided with the lid portion 5 on the upper end portion. An abutting portion 86 that abuts the lid plate 81 of the lid 5 and closes the container body 90 is provided at the upper end of the tubular portion 87. Further, since the lid 5 is bent so that the connecting pieces 84 and 82 for connecting the lid 5 and the tubular portion 87 and between the connecting piece 84 and the connecting piece 82 are overlapped with each other, the connecting piece 84 and the connecting piece 82 are bent. The bent portion 73 is directly or indirectly connected.
Further, the material container 80 includes a lid fixing mechanism that fixes the lid 5 to the container body 90. The lid fixing mechanism of the second embodiment is configured by the notch 110 formed in the lid 5, the locking member 85, and the elastic piece 45.

The entire material container 80 of the second embodiment is formed by integral molding of resin. Any resin may be used as the material of the material container 80 as long as it satisfies the requirements of the material container 80 such as thermoplasticity, rigidity, elasticity, transparency, solvent resistance, and cost. Good. As the resin satisfying such a condition, for example, polyethylene terephthalate, thermopolyolefin, polypropylene and the like are considered.
However, the second embodiment is not limited to forming the material container 80 by resin integral molding. The material container 80 may use a material other than resin, such as metal, for all or part of the material container 80.

As shown in FIG. 12, the bottom surface 83 is a bottom surface that seals the inside of the container body 90 together with the container body 90 that contains the material. The bottom surface 83 includes a fragile fragile portion 831 at least in part. The fragile portion 831 of the second embodiment is a portion where breakage is more likely to occur than the base portion 832 which is another portion of the bottom surface 83. In the second embodiment, the fragile portion 831 is a thin film portion, and the base portion 832 is a thick film portion having a larger thickness than the thin film portion. By doing so, the second embodiment can form the fragile portion 831 that is easier to tear than the base portion 832.

In addition, as shown in FIG. 13, the bottom surface 83 connects the fragile portion 831 and the base portion 832 that is more difficult to break than the fragile portion 831, and connects the inner surface of the container body 90 and the base portion 832 before and after the fragile portion 831 is ruptured. And a connection portion 833. The connection portion 833 is in a state of connecting the inner surface of the container body 90 and the base portion 832 before and after the fragile portion 831 is broken. That is, the connecting portion 833 is a portion that is connected to the inner surface of the container body 90 before breaking and is less likely to break than the fragile portion 831. Such a connecting portion 833 is connected to the inner surface of the container body 90 as a part of the bottom surface 83 before the fragile portion 831 is broken, and the fragile portion 831 is missing from the bottom surface 83 after the fragile portion 831 is broken. The remaining state remains on the inner surface of the container body 90.
By doing so, it is possible to prevent the base portion 832 from separating from the container body 90 and closing the tubular portion 89 after the fragile portion 831 is broken, or the broken pieces being mixed into the material.

14(a) and 14(b) are diagrams for explaining a process in which the bottom surface 83 breaks. FIG. 14A shows a state before the flow passage convex portion 63 a shown in FIG. 10 is inserted into the tubular portion 89. FIG. 14B shows a state in which the flow path convex portion 63 a is inserted into the cylindrical portion 89 and the bottom surface 83 is broken. In FIG. 14B, the fragile portion 831 is broken at the bottom surface 83, and the periphery of the base portion 832 is lost. Therefore, the base portion 832 separates from the inner surface of the tubular portion 89 and is pushed up by the flow path convex portion 63a and turned up upward.
In addition, a step portion 232 is formed in the circumferential direction on the flow passage convex portion 63a. On the other hand, the cylindrical portion 89 also has a step portion 191 on the inner surface of the cylindrical portion 89 in a circumferential shape. The flow path convex portion 63a inserted into the tubular portion 89 is fixed by the step portion 232 engaging with the step portion 191, and prevents the flow channel convex portion 63a from coming off the tubular portion 89.
In such a state, for example, the first partial flow channel 62x (see FIG. 8) formed in the flow path convex portion 63a and the inside of the container main body 90 communicate with each other, and the material flows from the container main body 90 to the flow path convex portion 63a. It begins to flow.

(Holder of flow path switching mechanism)
15(a), 15(b) and 15(c) are views for explaining the holder 70 of the second embodiment. FIG. 15A shows a state before the flow path switching mechanism 3 of the second embodiment is held by the holder 70. 15B shows a process in which the flow path switching mechanism 3 is held by the holder 70, and FIG. 15C shows a state in which the holding of the flow path switching mechanism 3 by the holder 70 is completed.
The holder 70 holds the flow path switching mechanism 3, and the flow path switching mechanism 3 is inserted from at least one direction intersecting the column direction (y direction and −y direction) of the second members 20 in the flow path switching mechanism 3. The insertion groove 70c and the locking projection 70b that locks when the flow path switching mechanism 3 inserted in the insertion groove 70c moves in the -y direction are alternately provided.
As shown in FIG. 15A, in the flow path switching mechanism 3, the second members 20 (FIG. 7 etc.) are arranged in a line along the y-axis. In the second embodiment, the y direction and the −y direction will be referred to as the column direction of the second members 20. On the other hand, the holder 70 includes a substrate 70a that is long in the y-axis direction, and locking protrusions 70b and an insertion groove 70c that are provided on each of two longitudinal sides of the substrate 70a. The locking projections 70b and the insertion grooves 70c are alternately provided along the above-mentioned sides.

In such a holder 70, in the second embodiment, the holder engaging portion 65 formed on the lower surface 61c of the flow path switching mechanism 3 is aligned with the insertion groove 70c and slid in the direction of arrow B in the drawing. On the substrate 70a. The direction in which the flow path switching mechanism 3 is slid with respect to the holder 70 is not limited to the direction indicated by the arrow B. As another direction, the z-axis direction shown in the figure can be considered. When the holder 70 holds the flow path switching mechanism 3 from the z-axis direction, the flow path switching mechanism 3 is placed on the substrate 70a from above with the holder engaging portion 65 aligned with the insertion groove 70c.
The holder 70 of the second embodiment is not limited to the configuration in which the flow path switching mechanism 3 is inserted into the insertion groove 70c from the orthogonal direction, but is inserted from the direction intersecting the arrangement direction of the second members 20. Any direction may be used as long as it is inserted. The insertion direction of the flow path switching mechanism 3 can be arbitrarily set according to the shape and design of the insertion groove 70c.

Next, in the second embodiment, as shown in FIG. 15B, the flow path switching mechanism 3 on the substrate 70a is arranged on the substrate 70a in the arrangement direction of the second members 20 indicated by the arrow C in the figure. To move. After the movement, the flow path switching mechanism 3 is fixed on the holder 70 as shown in FIG. More specifically, the surface of the holder engagement portion 65 of the second embodiment is a tapered surface that spreads downward from the lower surface 61c. On the other hand, the locking convex portion 70b has a surface on the side in contact with the holder engaging portion 65 which is a reverse taper surface along the surface of the holder engaging portion 65. When the flow path switching mechanism 3 moves in the direction of arrow C by one locking protrusion 70b, the position of the holder engagement portion 65 coincides with the locking protrusions 70b on both sides of the substrate 70a in the short side direction. At this time, it is possible to prevent the holder engaging portion 65 and the locking convex portion 70b from engaging with each other, preventing the holder engaging portion 65 from being locked by the locking convex portion 70b and the flow path switching mechanism 3 coming off the holder 70. it can. If the holder 70 is made of a material such as a resin having elasticity, the holder engagement portion 65 receives a force in the compression direction from the locking projections 70b on both sides and is engaged with the locking projection 70b. It will be even stronger.
According to the holder 70 of the second embodiment, when setting the flow path switching mechanism 3 at an arbitrary position of the holder 70, it is necessary to move the flow path switching mechanism 3 to the fixed position in the direction of arrow C. Absent. Therefore, the flow path switching mechanism 3 can be easily set in the holder 70.

[Third embodiment]
Next, a third embodiment of the present invention will be described. The third embodiment relates to the material container used in the material supply unit described above. Prior to the specific description of the material container of the third embodiment, the purpose of the invention of the material container of the third embodiment will be described below.

Some devices for synthesizing drugs by chemical treatment are capable of synthesizing a plurality of types of drugs with one device. In synthesizing a drug, a mechanism for supplying a material corresponding to this drug is required. Here, the “material” includes a substance, a drug (reagent), a catalyst, water and the like used for synthesizing a drug.
When synthesizing a plurality of types of drugs in one apparatus, the mechanism for supplying the material to the reaction vessel is shared by the plurality of synthesizing processes. In such a mechanism, in order to easily change the material corresponding to each drug, there is a mechanism in which an arbitrary material can be set in the supply mechanism and the material to be set is changed according to the drug to be synthesized. In addition, in such a mechanism, it is possible to prevent contamination (including Contamination/Carry over) of a drug used in another synthesis process or a product produced in another process in the synthesis process. Therefore, it is preferable that at least a part of the supply mechanism including the material container is disposable. As a container for materials used for synthesizing a drug, for example, a vial container is used in the synthesizer described in JP 2010-270068 A (hereinafter referred to as Reference Document 1).

Further, in the fields of biochemistry and molecular biology, the containers described in Japanese Patent Application Laid-Open No. 10-323176 (hereinafter referred to as Reference 2) and Japanese Patent Publication No. 2014-507256 (hereinafter referred to as Reference 3). Is used as a container for the polymerase chain reaction. Each of the containers described in References 2 and 3 has an opening at the upper end of the container body and a lid capable of opening and closing the opening, and the “bottom” on the side opposite to the lid of the container is closed. ing. Then, the liquid sample is injected and taken out from the opening portion with a pipette.

When the material is set in the vial container used in the synthesizer described in Reference 1, the rubber stopper of the vial container is sealed with an aluminum thin film or the like. In the case of a solid material, it is dissolved in a solvent, and a needle having a fluid flow path (hereinafter referred to as “injection needle”) is inserted into a rubber stopper, so that the flow path on the material supply mechanism side and the vial It is in circulation with the inside.
However, when the material is contained in the vial container in this manner, the remaining amount of the material remaining in the vial container becomes a problem as the amount of liquid supplied to the supply mechanism side decreases.
In addition, the containers described in References 2 and 3 are premised on the injection and removal of a liquid sample by a pipette, and it is assumed that the container is applied to a material supply mechanism for a flow path of an automated synthesizer. Not not.
The third embodiment is made in view of the above points, and relates to a material container in which the remaining amount of the material is small and the material can be easily attached to and detached from the supply mechanism. Moreover, the third embodiment relates to a material supply unit using such a material container.

Hereinafter, a third embodiment of the present invention will be described with reference to the drawings. In all the drawings, the same constituents will be referred to with the same signs, while omitting their overlapping descriptions. Further, in the third embodiment, the material container 1001 and the material supply unit 1004 have the lid 1005 side up and the receiving member 1002 side down with respect to the material container 1001 when the material container 1001 is set in the receiving member 1002. To do. Such a vertical direction is determined independently of the gravity direction.
Moreover, FIGS. 16 to 24 shown in the third embodiment are for the purpose of explaining the mechanism of the material container 1001 and the material supply unit 1004 and the positional relationship thereof, and the length and thickness of each member. The width and the like are not necessarily shown accurately.

[Material supply unit]
FIG. 16 is a perspective view for explaining the material supply unit 1004 of the third embodiment. The material supply unit 1004 includes a material container 1001 according to the third embodiment, a convex portion 1023a that breaks the fragile portion 1031 (FIGS. 22 and 23) of the material container 1001, and a convex portion inside the convex portion 1023a. The receiving member 1002 has a flow channel 1231 (FIG. 24) that communicates with the material container 1001 in a state in which the fragile portion 1031 is broken by the 1023a and is inserted into the bottom surface 1003. An opening end of the flow path 1231 is opened at the tip of the convex portion 1023a.
In the third embodiment, the material container 1001 is used for synthesizing a compound or drug by a chemical treatment, and the use of the material container 1001 for mixing food and drink is excluded. Further, when the material container 1001 is used for synthesizing a radioactive compound or a radiopharmaceutical (including macromolecules or antibodies labeled with a radionuclide, hereinafter also collectively referred to as “radioactive agent”), the material container 1001 is used. The housing contains synthetic materials such as radiopharmaceuticals. Examples of materials for synthesizing radiopharmaceuticals include substances (label precursors) used for synthesizing radiopharmaceuticals, drugs (reagents), catalysts, water and the like.

The receiving member 1002 is a member that is set in a synthesizer (not shown) for synthesizing a radiopharmaceutical and is used for supplying a material used in a chemical reaction to the synthesizer. The receiving member 1002 includes a main body 1021 having at least wall surfaces 1021a, 1021b, 1021c, 1021d, 1021e, a convex portion 1023a provided on the wall surface 1021a of the main body 1021, and a convex portion 1023e provided on the wall surface 1021e. The receiving member 1002 has a through hole 1042 provided in the main body 1021 and having a rectangular cross section, and a switching unit 1043 inserted into the through hole 1042. The switching unit 1043 has a flow path (not shown), and is provided in both directions of an axis orthogonal to the length direction of the receiving member 1002 so as to contact and separate the flow path and the flow path 1231 formed in the convex portion 1023a. Can be moved. The switching unit 1043 is moved by pushing or pulling the grip portion 1041 by an actuator (not shown) or the like.

The material container 1001 includes a container body 1010 (FIGS. 17, 18, and 21) that is a container body portion that is long in the vertical direction. The container body 1010 connects a tubular portion 1017 having a tubular shape with a constant outer diameter and an inner diameter, a tubular portion 1019 having a constant outer diameter and an inner diameter smaller than the tubular portion 1017, and the tubular portion 1017 and the tubular portion 1019. And a tapered portion 1018 having an inclined surface. A bottom surface 1003 is provided between the boundary between the tapered portion 1018 and the tubular portion 1019 and the lower end portion 1049 of the tubular portion 1019.

Further, the material container 1001 includes a lid portion 1005 at the upper end portion. An abutting portion 1016 that abuts the lid plate 1011 of the lid 1005 and closes the container body 1010 is provided at the upper end of the tubular portion 1017. Further, since the lid 1005 is bent so that the connecting pieces 1014 and 1012 that connect the lid 1005 and the tubular portion 1017 are between the connecting pieces 1014 and 1012 and the connecting pieces 1014 and 1012, the connecting pieces 1014 and 1012 are overlapped. The bent portion 1013 is directly or indirectly connected.
The material container 1001 also includes a lid fixing mechanism that fixes the lid portion 1005 to the container body 1010. The lid fixing mechanism of the third embodiment includes a notch 1110 formed in the lid 1005, a locking member 1015, and an elastic piece 1045 (FIG. 18).

In the material supply unit 1004 described above, the receiving member 1002 has a plurality of convex portions 1023a having a convex shape. The material container 1001 includes a bottom surface 1003 (FIGS. 17 to 23) inside the cylindrical portion 1019. In the third embodiment, the material container 1001 can be set in the receiving member 1002 by inserting the convex portion 1023a into the bottom surface 1003. With such a configuration, the material container 1001 can be easily set on the receiving member 1002.

Further, in the material container 1001 of the third embodiment, the bottom surface is broken to take out the material, so that the flow path of the material having a relatively large diameter can be secured. Therefore, in the third embodiment, the remaining amount of the container body 1010 in the container body 1010 can be reduced. Further, since the material container 1001 can be arbitrarily replaced with the receiving member, the material can be easily attached to and detached from the supply mechanism.
Further, in the third embodiment, a material container 1001 containing an arbitrary material corresponding to a radiopharmaceutical or the like to be synthesized is set in the receiving member 1002, and a material containing another material when synthesizing another radiopharmaceutical or the like. The container 1001 can be set on the receiving member 1002. With this configuration, the material to be supplied can be easily changed according to the radiopharmaceutical or the like synthesized by the synthesizer. Furthermore, in the third embodiment, by making the material container 1001 and the receiving member 1002 disposable, it is possible to prevent contamination due to materials, residues, and products in the synthesizer.

[Container body]
Next, the material container 1001 shown in FIG. 16 will be described.
17, FIG. 18, FIG. 19, FIG. 20, FIG. 21, and FIG. 22 are diagrams for explaining the configuration of the container body 1010 of the material container 1001. 17 and 18 are perspective views of the material container 1001. FIG. 17 shows a state in which the lid 1005 closes the opening 1047, and FIG. 18 shows a state in which the lid 1005 opens the opening 1047. ing. FIG. 19 is a top view of the material container 1001 shown in FIG. 18 seen from the direction of arrow IV. FIG. 20 is a bottom view of the material container 1001 shown in FIG. 18 as seen from the direction of arrow V. 21 is a cross-sectional view of the material container 1001 shown in FIG. 18 along the arrow VI, and FIG. 22 is an enlarged view of the container body 1010 in which the range enclosed by the broken line VII shown in FIG. 21 is enlarged. Is. FIG. 23 is an enlarged view of the bottom surface 1003 shown in FIG. 22 seen from the direction of arrow V in FIG.

As shown in FIGS. 16, 17 and 18, the material container 1001 is a bottomed container for containing a material used for chemical processing.
The container body 1010 and the bottom surface 1003 have a circular shape in a top view. The inner diameter of the container body 1010 is larger than the diameter of the bottom surface 1003. Although the inner diameter of the container body 1010 is constant in the third embodiment, the container body 1010 may have a different inner diameter. When the inner diameter of the container body 1010 changes, this inner diameter is larger than the diameter of the bottom surface 1003 at any place. In other words, the smallest inner diameter of the container body 1010 is smaller than the diameter of the bottom surface 1003.

That is, the material container 1001 has a container body 1010. The container body 1010 is composed of a tubular portion 1017, a tapered portion 1018, and a tubular portion 1019, and each of the tubular portion 1017, the tapered portion 1018, and the tubular portion 1019 has a circular cross section orthogonal to the longitudinal direction. There is. The diameter of the cross section of the tubular portion 1017, the tapered portion 1018, and the tubular portion 1019 decreases in the order of the tubular portion 1017, the tapered portion 1018, and the tubular portion 1019. The tapered portion 1018 forms a part of a cone that becomes thinner from the lower end of the tubular portion 1017 toward the upper end of the tubular portion 1019.
The third embodiment is not limited to the above configuration. For example, in the third embodiment, the tapered portion 1018 may be a cylindrical body having a constant diameter, or a tapered cylinder whose inclination changes. The diameter of the cylindrical portion 1019 may be constant or change.

In the material container 1001 of the third embodiment, a pressure difference is provided between the inside of the container body 1010 and the material supply destination, and the material is urged to flow out by the pressure difference. At this time, in the third embodiment, since the container body 1010 includes the tubular portion 1019, the flow of gas such as helium can be concentrated toward the tubular portion 1019 to promote the outflow of the material.
With the above configuration, in the third embodiment, the material smoothly flows out from the cylindrical portion 1019 along the inner peripheral surface of the tapered portion 1018, and the remaining amount of the material in the container body 1010 can be further reduced.

As shown in FIG. 18, a fitting portion 1111 is formed on the side of the lid plate 1011 of the lid portion 1005 facing the inside of the container body 1010. The fitting portion 1111 is fitted to the contact portion 1016 so that the outer peripheral surface thereof contacts the inner peripheral surface of the contact portion 1016, and the contact surface 1112 of the fitting portion 1111 and the contact surface of the contact portion 1016 side. 1162 is in contact with and closes the opening 1047. The lid fixing mechanism of the lid 1005 with the opening 1047 closed will be described later.

[Bottom]
Further, the container body 1010 has a bottom surface 1003 as shown in FIGS. 17 to 23. As shown in FIGS. 17, 18, 21, and 22, the bottom surface 1003 is a bottom surface that seals the inside of the container body 1010 that contains the material and the container body 1010. The bottom surface 1003 is provided at a distance from the lower end portion 1049 of the tubular portion 1019 and is prevented from being damaged.

As shown in FIGS. 20 and 23, the bottom surface 1003 includes a fragile fragile portion 1031 at least in part. The fragile portion 1031 of the third embodiment is a portion where breakage is more likely to occur than the base portion 1032 which is another portion of the bottom surface 1003. In the third embodiment, the fragile portion 1031 is a thin film, and the base portion 1032 is a thick film having a thickness larger than the thickness of the fragile portion 1031. By doing so, in the third embodiment, the fragile portion 1031 that is easier to break than the base portion 1032 can be formed.

However, the breakage in the third embodiment does not only mean that the bottom surface 1003 is broken, but also means that the bottom surface 1003 is in a state in which material movement occurs between the tapered portion 1018 and the cylindrical portion 1017. Therefore, breakage of the bottom surface 1003 includes tearing or breaking of the bottom surface 1003. The term “breakable” in the third embodiment means that the bottom surface 1003 can be broken by inserting a protrusion into the inside of the tubular portion 1019. The protrusion may be the protrusion 1023a, or the protrusion 1023a may be inserted into the tubular portion 1019 after the protrusion 1003 is broken using another protrusion.
The fragile portion that is easier to tear than the other portion can be formed, for example, by using a member that is easier to tear in one direction than the other portion in the weak portion. The fragile portion that is more easily cracked than the other portion is, for example, a portion having a film thickness smaller than that of the other portion is formed into a linear shape, and pressure is applied to the portion surrounded by the line, so that the bottom surface 1003 extends along the line. It can be formed by breaking it.

Also, as shown in FIG. 23, the bottom surface 1003 has a base portion 1032 that is more difficult to break than the weak portion 1031 and a connection portion 1033 that connects the inner peripheral surface of the container body 1010 and the base portion 1032 before and after the weak portion 1031 is broken. And further have.
Further, as shown in FIG. 23, the fragile portion 1031 of the third embodiment is arranged outside the base portion 1032 in the radial direction of the bottom surface 1003. With such a configuration, in the third embodiment, the periphery of the bottom surface 1003 is broken to separate the central portion base 1032 from the container body 1010, and the separated base portion 1032 is retained inside the container body 1010. You can That is, in the configuration in which the periphery of the bottom surface 1003 is the base portion and the central portion is the fragile portion 1031, the fragile portion 1031 is fractured and separated from the base portion, and it becomes impossible to control the position of the fragment after fracture. Further, in the configuration in which the periphery of the bottom surface 1003 is the base portion and the central portion is the weak portion, the base portion 1032 remains on the inner peripheral surface of the tubular portion 1019, and the inner diameter of the tubular portion 1019, that is, the material flow path is narrowed. In the third embodiment in which the fragile portion 1031 is provided outside the base portion 1032, the broken fragile portion 1031 does not remain on the inner peripheral surface of the tubular portion 1019, and the diameter of the flow path of the material can be secured. Further, such a configuration is effective in reducing the amount of material remaining in the container body 1010.

Furthermore, as shown in FIG. 23, the third embodiment has a portion 1034 that is gently curved so that the shape of the outer edge of the connection portion 1033 is convex inward toward the base portion 1032. With such a configuration, in the third embodiment, it is possible to prevent the material from remaining around the connection portion 1033 and to reduce the remaining amount of the material in the container body 1010.

As shown in FIGS. 19, 20, and 22, the bottom surface 1003 of the third embodiment has a step between the fragile portion 1031 and the base portion 1032 only on the lower side. That is, on the bottom surface 1003, the base portion 1032 is thickened downward. Such a shape of the bottom surface 1003 depends on the forming process of the material container 1001, and the base portion 1032 may be thickened toward the upper side of the bottom surface 1003. It may also be thicker on both sides. However, it is preferable that the thicknesses of the fragile portion 1031 and the base portion 1032 change sharply at the position where breakage is desired from the viewpoint of reproducibility of the breakage position.

In the third embodiment, the above-mentioned connecting portion 1033 is formed of a thick film that is continuous with the base portion 1032. By doing so, the connecting portion 1033 has the same strength as the base portion 1032, and the fragile portion 1031 can be broken before the connecting portion 1033 and the base portion 1032 are broken. Further, when the material container 1001 is integrally molded by injection molding or the like of resin, it is advantageous from the viewpoint of resin filling property, etc. to form the connection portion 1033 with the same film thickness as the base portion 1032.
The third embodiment is not limited to the configuration described above. For example, in the third embodiment, the effect of reducing the material remaining in the container body 1010 can be obtained even when the entire bottom surface 1003 is the weakened portion 1031.

Further, in the above structure, the bottom surface 1003 is formed between the boundary between the tapered portion 1018 and the tubular portion 1019 and the lower end portion 1049. Such a position of the bottom surface 1003 is an appropriate position for engaging the convex portion 1023a with the step portion 1191 and pushing up the bottom surface 1003 to break the fragile portion 1031. For example, when the bottom surface 1003 is closer to the lower end portion 1049, the convex portion 1023a may not be inserted and fixed, and the convex portion 1023a may vary in the direction of applying pressure to the bottom surface 1003. From this, in the third embodiment, the convex portion 1023a can always apply a force to the bottom surface 1003 from the optimum direction. The optimum direction in the third embodiment is a direction perpendicular to the bottom surface 1003.

[Lid fixing mechanism]
Next, the lid fixing mechanism of the third embodiment will be described.
24(a), 24(b), and 24(c) are views for explaining the lid fixing mechanism of the third embodiment. 24A shows a state in which the lid 1005 opens the opening 1047, FIG. 24B shows a state in which the opening 1047 is closed by the lid plate 1011 of the lid 1005, and FIG. The state where the lid plate 1011 is fixed is shown.
As described above, the container body 1010 is provided with the bottom surface 1003 at one end in the axial direction perpendicular to the bottom surface 1003. Further, the other end has an opening 1047, and the opening 1047 is closed by a lid 1005 having a lid plate 1011 parallel to the bottom surface 1003. The lid fixing mechanism of the third embodiment includes a cutout 1110 formed on the outer surface of the lid plate 1011, an elastic piece 1045 connected to the container body 1010, and a cutout 1110 provided at the tip of the elastic piece 1045. And a locking member 1015 having a portion larger than the width w of the cutout. The elastic piece 1045 is held in the notch 1110 and is fixed to the outer surface of the lid plate 1011 in a stretched state by a locking member 1015.

Specifically, as shown in FIGS. 24A to 24C, a notch 1110 is formed in the lid plate 1011 of the third embodiment. As shown in FIGS. 19 and 20, the cutout 1110 of the third embodiment has a “U” shape in plan view. However, the third embodiment does not limit the shape of the cutout 1110 in a closed view. The cutout 1110 may have any shape as long as it can hold the elastic piece 1045.
A locking member 1015 having a portion larger than the width w of the cutout portion 1110 is connected to the tip of the elastic piece 1045. The locking member 1015 of the third embodiment is a sphere, and the diameter from a portion very close to the boundary with the elastic piece 1045 to a portion very close to the outer surface on the opposite side is larger than the width w of the notch.

In the above configuration, first, as shown in FIG. 24B, the user of the material container 1001 closes the opening 1047 with the lid 1005 so that the lid 1011 is superposed on the opening 1047. Next, the user fits the elastic piece 1045 into the cutout portion of the cutout portion 1110, as shown in FIG. In the third embodiment, when the user fits the elastic piece 1045 into the cutout portion 1110, the elastic piece 1045 and the like are designed to have a length that extends the elastic piece 1045 while pulling the locking member 1015 upward. deep. In this way, even when the user is not applying force to the locking member 1015 and the elastic piece 1045, it is possible to prevent the locking member 1015 from hitting the notch portion 1110 and returning the elastic piece 1045 to the state before the extension. I'm out. Therefore, the elastic piece 1045 according to the third embodiment is fixed to the outer surface of the lid plate 1011 in a stretched state.
With the above configuration, in the material container 1001 according to the third embodiment, the lid 1005 is in close contact with the opening 1047, and the airtightness and liquid-tightness of the container body 1010 can be improved.

As described above, in the material container 1001 according to the third embodiment, the bottom surface 1003 is broken to take out the material, so that the flow path of the material having a relatively large diameter can be secured. Therefore, in the third embodiment, the remaining amount of the container body 1010 in the container body 1010 can be reduced. Further, in the material container 1001 and the material supply unit 1004, the material container 1001 can be arbitrarily replaced with respect to the receiving member, so that the material can be easily attached to and detached from the supply mechanism.

[Fourth Embodiment]
Next, a fourth embodiment of the present invention will be described. 25 and 26 are views for explaining the flow path switching mechanism 7 according to the fourth embodiment of the present invention. 25 is a perspective view of the flow path switching mechanism 7, and FIG. 26 is an exploded perspective view of the flow path switching mechanism 7 shown in FIG.
As shown in FIGS. 25 and 26, the flow path switching mechanism 7 is configured by combining the first member 30 and the second member 40 as in the first embodiment and the second embodiment. The combination of the first member 30 and the second member 40 is performed by inserting the second member 40 into the hollow portion 36.
The second member 40 has a rectangular parallelepiped main body 44 having an upper surface 41a, side surfaces 41b and 41d, a lower surface 41c, a front surface 41e and a rear surface 41f, and a driving force receiving convex portion 47 is formed on the front surface 41e of the main body 44. The first member 30 has a main body 34 having an upper surface 31a, side surfaces 31b and 31d, a lower surface 31c, a front surface 31e and a back surface 31f. The main body 34 is a frame body having a predetermined thickness and has a hollow portion 36. Therefore, the front surface 31e and the back surface 31f have a frame shape.
Flow passage projections 331a and 332a are formed on the upper surface 31a, and flow passage projections 331d and 332d are formed on the side surface 31d. A holder engaging portion 35 is formed on the lower surface 31c.

The first member 30 has first partial flow paths 321a, 322a, 321d, 322d. The first partial flow path 321a has openings 321aa and 321ab at both ends, and the first partial flow path 322a has openings 322aa and 322ab at both ends. Further, the first partial flow path 321d has the openings 321da and 321db at both ends, and the first partial flow path 322d has the openings 322da and 322db at both ends. The second member 40 has second partial flow paths 42a and 42b. The second partial flow channel 42a has an opening 42aa on the upper surface 41a and an opening 42ab on the side surface 41d. The second partial flow path 42b has an opening 42ba on the upper surface 41a and an opening 42bb on the side surface 41d.
In the fourth embodiment, the pre-movement communication channel that is the first partial flow channel that communicates with the second partial flow channel when the second member 40 is at the predetermined position, and the second member along the axis from the predetermined position. A post-movement communication channel that is a first partial channel that communicates with the second partial channel when moved. In the above configuration, the first partial flow paths 321a and 321d are the pre-movement communication flow paths of the fourth embodiment, and the first partial flow paths 322a and 322d are the post-movement communication flow paths.

For example, in the fourth embodiment, the fluid is introduced into the second partial flow passage 42a at a position communicating with the first partial flow passages 321a and 321d. The fluid is introduced by providing a pressure difference between the second partial flow path 42a and the fluid introduction destination. After the second partial flow channel 42a is filled with the fluid, in the fourth embodiment, the second member 40 is moved along the x-axis to move the second partial flow channel 42a to the first partial flow channel 322a or the first partial flow channel. The fluid in the second partial flow path 42a is led out from the passage 322d to a lead-out destination different from the fluid feed-in source.
Such a configuration is useful when a small amount of a portion of a fluid in the course of a chemical reaction is sampled. That is, in the fourth embodiment, if the flow path switching mechanism 7 is connected to a reaction container for chemical reaction or the like, the reaction fluid can be sampled without opening the container as well as stopping the reaction. it can.
FIG. 27 is a diagram showing a trace amount sampling system using the flow path switching mechanism 7 of the fourth embodiment. FIG. 28 is a diagram for explaining the fluid flowing through the flow path switching mechanism 7 in the trace amount sampling system of FIG. Note that, in FIG. 27, the capillary 107 is a glass capillary filled with silica gel, and is manufactured and sold by FutureChem under the product name of Radio-Cap, for example. The capillary 107 and the flow path switching mechanism 3 are connected by a liquid transfer tube 109, and the fluid moves between the capillary 107 and the liquid transfer tube 109, or the outside of the flow path switching mechanism 7 via the liquid transfer tube 109. To do.
A reaction solution is stored in the reactor 103, and various organic reactions are progressing in the solvent in the reaction solution. Further, the developing solvent container 105 is filled with a developing solvent for chromatography, which is appropriately blended for the analysis of the target compound.
The procedure for using the trace amount sampling system shown in FIGS. 27 and 28 will be described below. First, the inside of the reactor and the second partial flow passage 42a is depressurized through the flow passage convex portion 331a, so that the inside of the second partial flow passage 42a is filled with the reaction liquid (FIG. 28, arrow E). Then, the driving force receiving convex portion 47 is moved in the −x direction to connect the flow path 42a to the openings 322ab and 322da. Then, by depressurizing the inside of the capillary 107 through the developing solvent container 105 and the material supply unit 100, the reaction liquid and the developing solvent are introduced into the capillary 107 (arrow lines D, F, G, H), and the reaction liquid Component is developed in the capillary 107 together with the developing solvent. When the developing solvent has spread to a predetermined distance (height) in the capillary 107, the depressurization is stopped, the capillary 107 is removed, and detection is performed with a detector suitable for the target compound. For example, a radio TLC scanner can be used to detect compounds that emit radiation. After that, when the driving force receiving convex portion 47 is pushed in and further reaction tracing is performed, the same operation is repeated.

As described above, in the configuration of the fourth embodiment, since the fluid in the reaction can be sampled over time over a plurality of times, it is possible to trace the change in the component over time of the fluid due to the reaction. By tracking the change in the composition of the fluid over time, it is determined whether the reaction rate of the fluid is the desired rate, and the reaction is controlled to the desired state by feeding back conditions such as heating and the amount of reagent input. be able to.
Further, in the above-described configuration, the second partial flow channel 42a is separated from the first partial flow channel 321a and the first partial flow channel 321d when the amount of fluid that fills the second partial flow channel 42a is collected. Then, the fluid that fills the second partial flow path 42a communicates with the first partial flow path 322a and the first partial flow path 322d and is drawn out. Therefore, in the fourth embodiment, a sufficient amount of fluid that accurately fills the second partial flow path 42a can be sent to the sampling solution.
The above operation can be performed by moving the second partial flow path 42b from the position communicating with the first partial flow paths 322a, 322d to the position communicating with the first partial flow paths 321a, 321d.

[Fifth Embodiment]
29(a) and 29(b) are diagrams for explaining the first member 50 and the second member 20 of the fifth embodiment. 29A is a perspective view of the first member 50 of the fifth embodiment, and FIG. 29B is a perspective view of the second member 20. The second member 20 shown in FIG. 29(b) is the same member as the second member 20 shown in FIG. 1(c).
As shown in FIG. 29A, the first member 50 is combined with the second member 20 to form a flow path switching mechanism. The first member 50 is formed with first partial flow paths 12a, 12b, 12d. The second member 20 moves in the ±x direction in FIG. 29 so that any one of the second partial flow paths 22a, 22b, 22c of the second member 20 is combined with the first partial flow paths 12a, 12b, 12d.
When the first partial flow passage 12a is combined with the second partial flow passage 22a, the flow passages 12a-22a-12d are formed. Further, when the first partial flow channel 12a is combined with the second partial flow channel 22c, the flow channels 12a-22c-12b are formed, and when the first partial flow channel 12b is combined with the second partial flow channel 22b, the flow is Channels 12b-22b-12d are formed.

At least a part of the first member 50 is a frame, and in the fifth embodiment, the entire main body 14 has a frame shape. Here, the frame means a shape that partially surrounds at least one space. That is, the frame body in the fifth embodiment does not cover the entire space, and for example, as shown in FIG. 29A, the hollow portion 16 that is a space into which at least a part of the second member 20 is fitted. Are enclosed except for the surface facing in the ±x direction. Further, the frame body serving as the first member 50 includes a reference strained portion having a predetermined rigidity and an easy strained portion 55 having a lower rigidity than the reference strained portion.

In FIG. 29A, the easy strain portions 55 are formed at the four corners of the main body 14 one by one. The reference strain portion in the fifth embodiment is a portion of the main body 14 excluding the easy strain portion 55.
In the fifth embodiment, the rigidity of the easy strain portion 55 is reduced by making the wall thickness of at least a portion of the easy strain portion 55 smaller than the wall thickness of the reference strain portion. In FIG. 29A, the easily strained portion 55 includes two thin portions 55 a, and the two thin portions 55 a are thinner than the other portions of the main body 14. In the fifth embodiment, a thicker portion 55b is a portion that is thicker than the thin portion 55a of the reference strained portion.
The frame-shaped main body 14 is expanded in all directions when the second member 20 is fitted because the easily deformed portion 55 is formed. At this time, the thick portion 55b is not locally distorted, and the entire thick portion 55b expands toward the outside of the frame.

The easily strained portion 55 is a portion having a lower rigidity than the reference strained portion and a larger strain amount than the reference strained portion. Here, “rigidity” refers to the magnitude of strain when an external force is applied inward and outward. The “distortion amount” means, for example, a deformation amount before and after the strain when the easy strain portion 55 and the reference strain portion are distorted by applying the same force.
The shape of the thin portion 55a is not limited to the shape shown in FIG. For example, in the fifth embodiment, the thin portion 55a may have any width, thickness and number. Further, in the fifth embodiment, a cut may be formed in place of the thin portion 55a to reduce the rigidity of the easily strained portion 55. In such a case, the rigidity of the easily strained portion 55 can be adjusted by the number and depth of the cuts.

The reference strain portion and the easy strain portion 55 of the first member 50 of the fifth embodiment may be provided in the main body of the first member 30 of the third embodiment, and the reference strain portion and the easy strain portion 55 are included. The flow path switching mechanism composed of the first member 30 can be used for the above-mentioned trace amount sampling system.

Further, the fifth embodiment is not limited to one in which the rigidity of the easily strained portion 55 is adjusted by the wall thickness. Regarding the rigidity of the main body 14, for example, the hardness of the material of the main body 14 may be different between the easy strain portion 55 and the reference strain portion. Furthermore, in the fifth embodiment, a hole may be opened in a part of the main body 14 to form the easily strained portion 55. In this case, the rigidity of the easily strained portion 55 can be adjusted by the number and diameter of the openings.

[Sixth Embodiment]
Next, a sixth embodiment of the present invention will be described. FIG. 30 is a diagram showing a flow channel switching system including the flow channel switching device 2 of the sixth embodiment. The flow path switching device 2 is used by attaching the flow path switching mechanism and the material container 80 described above, and an application example thereof is a radiopharmaceutical synthesizing device. The flow path switching mechanism 4 attached to the flow path switching device 2 is a combination of a first member in which one or a plurality of first partial flow paths are formed and the first member in a movable state, and a plurality of or one By combining the second member having the two partial flow paths, the driving force receiving portion that receives the driving force that moves the second member in both directions of the one axis, and the first member and the second member, the first partial flow The passage and the second partial flow passage communicate with each other to form a passage, and the second member moves in both directions of the one axis while maintaining the combination of the first member and the second member, whereby Any type may be used as long as the combination of the partial flow path and the second partial flow path is changed to switch the flow path to another flow path.
The flow path switching device 2 shown in FIG. 30 has a unit body 8 and a pedestal 9 on which the unit body 8 is placed and fixed. The unit body 8 is composed of three flow path switching mechanism holding units 8A, 8B and 8C. In the sixth embodiment, it is assumed that the flow path switching mechanism holding units 8A, 8B, 8C all have the same configuration. Therefore, in the sixth embodiment, the flow path switching mechanism holding unit 8A will be described below, and will be replaced with the description of the flow path switching mechanism holding unit 8B and the flow path switching mechanism holding unit 8C.

The flow path switching mechanism holding unit 8A includes a holding surface 912 that holds the flow path switching mechanism 4 of the sixth embodiment, and a holder 240 that abuts the flow path switching mechanism 4 from the x direction (front) in FIG. 31) has a holder wall portion 240c. Engagement holding portions 911 that engage with the flow path switching mechanism 4 and function as stoppers of the flow path switching mechanism 4 are provided at both ends of the flow path switching mechanism 4 on the holding surface 912. The holding surface 912 has a length corresponding to the length of the flow path switching mechanism 4 in the y direction, and the flow path switching mechanism 4 is placed so as to be set between the engagement holding portions 911. The engagement holding portion 911 as described above is used for alignment when the flow path switching mechanism 4 is attached to the flow path switching device 2, and has a function of fixing the flow path switching mechanism 4.
Further, the flow path switching mechanism 4 can set the material container 80 and the solid phase extraction cartridge in the second member. In FIG. 30, the material container 80 is set in a part of the second member of the flow path switching mechanism 4, and the liquid transfer tube 109 communicating with the flow path formed by the flow path switching mechanism 4 is set in the material container 80 or the like. Although an example of connection is shown, the position, number, and combination are not limited to this, and can be selected variously according to the purpose.
Furthermore, the flow path switching device 2 of the sixth embodiment may include a thin-layer chromatography (Thin-Layer Chromatography) holding unit.

The flow path switching mechanism holding unit 8A is integrated with the flow path switching mechanism holding unit 8B and the flow path switching mechanism holding unit 8C to form a unit body 8 and is fixed to the mounting surface 91 of the pedestal 9. At this time, the flow path switching mechanism holding unit 8A may be indirectly fixed to the mounting surface 91 via the flow path switching mechanism holding units 8B and 8C, or may be fixed to the mounting surface 91. It may be directly fixed. Each of the flow path switching mechanism holding units 8A, 8B, and 8C is a flow path switching mechanism installation body to which the flow path switching mechanism 4 is attached. The flow path switching mechanism holding units 8A, 8B, and 8C are integrated by superimposing a plurality of them while shifting in the x direction. In FIG. 30, the three flow path switching mechanism holding units 8A, 8B, and 8C are stacked, but the number of flow path switching mechanism holding units is arbitrary, and the operability and the number of material containers 80 to be used are different. It is determined accordingly. Further, the flow path switching mechanism holding units 8A, 8B, 8C are not limited to those placed on the pedestal 9, and may be installed in any manner as long as the operability and stability are not impaired. Good.

The pedestal 9 has three side surfaces 95 (only the left side surface is visible in FIG. 30) perpendicular to the mounting surface 91, and the three side surfaces 95 surround three sides of the space 99. A small pedestal 94 is provided in a space 99 surrounded by the side surface 95 on three sides, and a reaction container 481 is set on the small pedestal 94. A cover 48n attached to the small pedestal 94 may be arranged around the reaction container 481. Inside the small pedestal 94, a temperature control mechanism for heating or cooling the reaction vessel 481, a stirring mechanism for stirring the reaction solution in the reaction vessel, a radiation detection mechanism used when performing a labeling reaction using a radionuclide, etc. You may prepare. The pedestal 9 has a container support portion 93 that supports the reaction container 481. The reaction container 481 includes a rubber septum 481a and a container body 481b sealed by the rubber septum 481a. The rubber septum 481a is formed with an insertion port 481c of a tube through which a reagent, an inert gas or the like contained in the material container 80 circulates or a reaction liquid in the reaction container 481 is taken in and out.
Above each of the three reaction vessels 481, a plurality of connection ports 96 for connecting a tube (not shown) to a gas supply mechanism and a decompression mechanism for supplying an inert gas used for adjusting the pressure inside the container body 481b are formed. ing.

31 to 34 are diagrams for explaining a configuration relating to driving of the flow path switching device of the sixth embodiment.
FIG. 31 is a view for explaining the inside of the flow path switching mechanism holding unit 8A, and shows a state in which the upper surface 8Aa of the flow path switching mechanism holding unit 8A shown in FIG. 30 is removed, in the z direction shown in FIG. It is a top view seen from below (-z direction). FIG. 31 shows a state in which the flow passage switching mechanism 4 is attached to the flow passage switching mechanism holding unit 8A, and a state in which the flow passage switching mechanism 4 is not attached to the flow passage switching mechanism holding units 8B and 8C. Is shown. Further, in FIG. 31, the material container 80 attached to the flow path switching mechanism 4 of the flow path switching mechanism holding unit 8A is not shown.

The flow path switching mechanism holding unit 8A is pushed by a motor 200, a coupling 222, one of which is connected to a gear head (not shown) of the motor 200, a ball screw portion 220 and a ball screw portion 220 which are connected to the other of the coupling 222. The bearing 230 is pulled. In the sixth embodiment, the flow path switching mechanism 4 including the plurality of second members 20 (10 pieces) is attached to the flow path switching device 2. The motor 200, the ball screw part 220, and the bearing part 230 function as a drive part, and 10 pieces of each are provided corresponding to each of the 10 second members 20. The motor 200, the ball screw portion 220, and the bearing portion 230 corresponding to one second member 20 are shown in the drawing as the individual drive portion 6.

FIG. 32 is an exploded perspective view for explaining the channel switching mechanism 4 of the sixth embodiment attached to the channel switching mechanism holding unit 8A. FIG. 33 is a diagram for explaining the flow path of the first member 46 of FIG. As shown in FIGS. 32 and 33, the flow path switching mechanism 4 is configured by combining the first member 46 and the second member 20. In the flow path switching mechanism 4, a plurality of second members 20 are arranged in the y-axis direction in the figure and combined with the first member 46. The first member 46 has an upper surface 41a, side surfaces 41b and 41d, a lower surface 41c, a front surface 41e, and a back surface 41f. A hollow portion 67 is formed in the first member 46, and the front surface 41e and the back surface 41f have a frame shape corresponding to the plurality of hollow portions 67. Flow passage protrusions 43a are formed on the upper surface 41a, and flow passage protrusions 43b and 43d are formed on the side surfaces 41b and 41d, respectively. Further, a holder engaging portion 69 is formed on the lower surface 41c.
Further, as shown in FIG. 33, in the main body 44 of the first member 46, the first partial flow paths 52a, 52b, 52c, 52d, 52e, 52f, 52g, 53h, 52i, 52j, 52k, 52o, 52p, 52q, 52r, 52s, 52t, 52u, 52v, 52w, and 52x are formed, and the first partial flow paths 52a to 52x communicate with the hollow portion 67, respectively. Openings 52ab to 52jb, openings (not shown) opened to face the openings 52ab to 52jb, and openings (not shown) of the first partial flow channels 52o to 52x are formed in the hollow portion 67. ing. In the sixth embodiment, similarly to the second embodiment, the second member 20 is inserted into the hollow portion 67, and the first partial flow passage and the second partial flow passage of the second member 20 inside the hollow portion 67 communicate with each other. To form a flow path.
However, in the flow path switching mechanism 4 of the sixth embodiment, an upper recess 48a and a lower recess 48b are provided between adjacent hollow parts 67 among the plurality of hollow parts 67 arranged in the y direction. The difference from the flow path switching mechanism 3 of the second embodiment is that it is different. The lower concave portion 48b is a space into which the locking convex portions 280ab and 280bb (FIG. 35) formed in the flow path switching mechanism holding portion 280 (FIG. 35) enter, as described later.

FIG. 34 is a schematic diagram for explaining driving the second member 20 of the flow path switching mechanism 4 in the flow path switching mechanism holding unit 8A, showing the individual drive unit 6 shown in FIG. There is. As shown in FIG. 34, the flow path switching mechanism 4 is placed on the holding surface 912 via the holder 240, and the holder 240 is a removal flow path switching device for facilitating the removal of the flow path switching mechanism 4. It has a mechanism holding portion 280.
As shown in FIG. 31, the flow path switching device 2 includes a motor 200, a coupling 222, a ball screw portion 220 and a bearing portion 230. Although the illustrated ball screw portion 220 does not show a ball, it has a ball, a shaft portion 220a, and a screw portion 220b (not shown). The bearing portion 230 is integrated with the holder 240. Further, in FIG. 34, the illustration of the coupling 222 is omitted.

In the above configuration, the motor 200, the ball screw portion 220, and the bearing portion 230 apply the driving force for moving the second member 20 in the + and − directions of the x-axis to the driving force receiving convex portion 27 of the flow path switching mechanism 4. It functions as a drive unit for giving to. In the sixth embodiment, this driving force is applied to the driving force receiving convex portion 27 via the holder 240 integrated with the bearing portions 230 and 230. The flow path switching mechanism holding receiver 280 provided in the holder 240 holds the second member 20 of the flow path switching mechanism 4 so that the first member 46 does not move while the second member 20 is stationary and driven by the drive unit. ..

In addition, in the sixth embodiment, the flow path switching mechanism 4 including the plurality of second members 20 is attached to the flow path switching device 2. The motor 200 that functions as a drive unit, the ball screw unit 220, and the bearing unit 230 include a plurality of individual drive units 6 that individually drive each of the plurality of second members 20.

The above configuration operates as follows. That is, the motor 200 is an electric motor such as a stepping motor, and is rotated by receiving power supply. The rotation of the motor 200 is transmitted to the ball screw portion 220 by the coupling 222. The shaft portion 220a of the ball screw portion 220 converts the rotation of the motor 200 into a linear movement. The screw portion 220b moves in the x direction when the motor 200 rotates to the right, for example, and moves in the −x direction when the rotation direction of the motor 200 is reversed. A bearing portion 230 integrated with the holder 240 is fixed to the screw portion 220, and the holder 240 moves together with the screw portion 220b.
As shown in FIG. 34, the holder 240 includes holder walls 240a and 240c and a holder bottom 240b. Regarding the holder wall portion 240a, a surface facing the flow path switching mechanism 4 is formed as an inner surface 240aa, a back surface of the inner surface 240aa is an outer surface 240ab, and a driving force receiving convex portion 27 of the second member 20 is formed between the inner surface 240aa and the outer surface 240ab. And an engaging portion 240ad that engages with. A surface of the holder wall portion 240c facing the flow path switching mechanism 4 is an inner surface 240ca, and a surface of the holder bottom portion 240b facing the flow path switching mechanism 4 is an inner surface 240ba.

The bearing portion 230 and the holder 240 are moved in the ±x axis directions by the ball screw portion 220. In the sixth embodiment, moving in the x direction is hereinafter referred to as “forward”, and moving in the −x direction is hereinafter referred to as “backward”. When the screw portion 220b moves in the -x direction, the holder 240 moves backward, and when the screw portion 220b moves in the x direction, the holder 240 moves forward. At this time, since the holder wall portion 240a of the holder 240 is engaged with only the second member 20 of the flow path switching mechanism 4 at the engaging portion 240ad, the first member 46 is fixed when the holder 240 retracts. The second member 20 is retracted while keeping it. At this time, a force in the −x direction is applied to the portion of the second member 20 that engages with the holder wall portion 240a, and a force in the −x direction is also applied from the holder wall portion 240c. Therefore, in the sixth embodiment, the force applied by the ball screw portion 220 is efficiently transmitted to the second member 20, and the second member 20 is smoothly moved while maintaining the airtightness between the second member 20 and the first member 46. Can be moved to.
On the other hand, when the holder 240 moves forward, the second member 20 moves forward while the first member 46 is held. The second member 20 can be moved forward until it comes into contact with the holder wall portion 240c.

As described above, in the sixth embodiment, the relative positional relationship between the first member 46 and the second member 20 is changed by moving the second member 20 forward and backward with respect to the first member 46. The combination of the connection between the first partial flow paths 52a to 52x of the first member 46 and the second partial flow paths 22a, 22b, 22c of the second member 20 changes due to the change in the relative position. As a result, with the configuration shown in FIG. 34, the flow paths formed in the flow path switching mechanism 4 can be switched.
Note that the sixth embodiment does not limit the individual drive unit 6 to the above configuration. For example, the individual drive unit 6 has one ball screw portion 220, and the movement amount of the holder 240 is adjusted at one place. However, the individual drive unit 6 of the sixth embodiment may include a plurality of adjustment locations for the movement amount of the holder 240, such as the ball screw portion 220, so that the movement amount of the holder 240 can be changed in multiple stages.

35(a), 35(b) and 35(c) are perspective views of the flow path switching mechanism holding/receiving portion 280 and the flow path switching mechanism 4 shown in FIG. In the sixth embodiment, the second members 20 are arranged in the y direction in the drawing, and the first member 46 is combined with the plurality of second members 20. The flow path switching mechanism holding/receiving section 280 includes two members, a first holding/receiving section 280a and a second holding/receiving section 280b. The first holding receiving portion 280a has a base portion 280aa that supports the first member 46, and a locking protrusion 280ab that is an engaging portion that is formed on the base portion 280aa and that engages with the first member 46. .. Further, the second holding receiving portion 280b has a base portion 280ba that supports the first member 46, and a locking convex portion 280bb that is an engaging portion that is formed on the base portion 280aa and that engages with the first member 46. ing.

Furthermore, in the sixth embodiment, the base portion 280aa, the base portion 280ba, the base portion 280aa, and the first member of the base portion 280ba are arranged in the arrangement direction (y direction). The member 250 is provided. The locking projection 280ab has an inclined portion 280ac that is inclined in the moving direction that moves in accordance with the length change by the spring member 250, and the length of the base portion 280aa and the base portion 280ba is changed by the spring member 250. When changed, the locking protrusion 280ab enters between the base portion 280aa and the first member 46. Further, the locking projection 280bb has an inclined portion 280bc that is inclined toward the moving direction that moves in accordance with the length change by the spring member 250, and the length of the base portion 280aa and the base portion 280ba is changed by the spring member 250. When changed, the locking protrusion 280bb enters between the base 280aa and the first member 46.

In the above description, in the sixth embodiment, the flow path switching mechanism holding and receiving portion 280 is made into two members, that is, the first holding and receiving portion 280a and the second holding and receiving portion 280b, so the base portions 280aa and 280ba are also two members. ing. However, the number of constituent members of the base portion of the sixth embodiment is not limited. The “length of the base portion” in the sixth embodiment refers to the total length of the base portions 280aa, 280b and the spring member 250 in the y direction. Further, the lengths of the base parts 280aa, 280b and the spring member 250 are changed by expanding and contracting the spring member 250 to change the distance between the first holding receiving part 280a and the second holding receiving part 280b.
However, the sixth embodiment is not limited to the configuration in which the interval between the base portions 280aa and 280b is changed by the spring member 250. For example, when the base portion is composed of two members, the two members are configured to be slidable with respect to each other, one of them is slid on the other, and the entire length of the base portions 280aa, 280b is changed by the overlapping amount. You may do it. Alternatively, the base portion may be configured to be bendable so that the base portion is shortened by applying a force from both ends of the base portion made of one member toward the center.

Next, the function of the flow path switching mechanism holding portion 280 of the sixth embodiment will be specifically described. FIG. 35( a) is a diagram for explaining how to attach the flow path switching mechanism 4 to the flow path switching device 2. As shown in FIG. 35A, the flow path switching mechanism 4 is placed on the base portion 280aa and the base portion 280ba from above the flow path switching mechanism holding and receiving portion 280. At this time, the flow path switching mechanism 4 is arranged so that the holder engaging portion 69 is inserted between the locking convex portions 280ab and 280bb. The flow path switching mechanism 4 is set on the holder 240 while being mounted on the flow path switching mechanism holding portion 280, and is attached to the flow path switching device 2.

35(b) and 35(c) are diagrams for explaining the removal of the flow path switching mechanism 4 from the flow path switching device 2. At this time, in the sixth embodiment, with the flow path switching mechanism 4 placed on the flow path switching mechanism holding and receiving portion 280, as shown in FIG. A force is applied so as to move in the direction of J, and at the same time, a force is applied so that the second holding receiving portion 280b moves in the direction of arrow K. The movement of the first holding receiving portion 280a and the second holding receiving portion 280b may be manually performed by the operator, or the first holding receiving portion 280a and the second holding receiving portion of the flow path switching device 2 may be moved. A mechanism for moving the portion 280b may be provided.
When the first holding receiving portion 280a and the second holding receiving portion 280b are moved in the directions opposite to each other, the holder engaging portion 69 is lifted and locked along the inclined portions 280ac and 280bc inclined in the moving direction. The convex portions 280ab and 280bb come out from the lower concave portion 48b of the first member 46 and enter under the holder engaging portion 69. At this time, the holder engagement portion 69 rides on the locking projections 280ab and 280bb, and the flow path switching mechanism 4 is easily removed from the flow path switching mechanism holding receiving portion 280.

In addition, the flow path switching mechanism holding receiving portion 280 of the sixth embodiment does not limit the locking convex portions 280ab and 280bb to the above-described configuration, but is inserted under the holder engaging portion 69 and the holder engaging portion 69 is used as a base. Any configuration may be used as long as it can be floated from the portions 280aa and 280ba. As such a configuration, for example, the inclined portion of the first holding receiving portion 280a is inclined toward the side opposite to the second holding receiving portion 280b, as opposed to the inclined portion 280ac, and the second holding receiving portion 280b is provided. It is assumed that the inclined portion is inclined toward the side opposite to the first holding receiving portion 280a. Then, the first holding receiving portion 280a and the second holding receiving portion 280b may be moved in directions away from each other.
Further, in the sixth embodiment, for example, a folded leaf spring member is provided in place of the locking protrusions 280ab and 280bb, and the first holding receiving portion 280a and the second holding receiving portion 280b are moved to hold the holder engaging portion. Alternatively, the leaf spring member may be inserted below 69 in a folded state. By doing so, the leaf spring member opens below the holder engaging portion 69 by its elastic force, and the holder engaging portion 69 can be floated from the base portions 280aa and 280ba.

The flow path switching device described above can transfer liquid to a desired position while switching the flow path by pressurization by a gas supply mechanism, suction by a decompression mechanism, or a combination thereof. By combining at least one of the control mechanism, the reaction vessel stirring mechanism, and the radiation detection mechanism, it becomes possible to realize a highly versatile radiopharmaceutical synthesizing device that is small in size and has little residual liquid in the flow channel.

The present invention described above has the following ideas.
<1> A flow path switching mechanism for switching a flow path through which a material used for chemical treatment is circulated, the first member having one or a plurality of first partial flow paths formed therein, and the first member in a movable state. A second member that is combined with a member and that has a plurality of or one second partial flow paths; and a driving force receiving portion that receives a driving force that moves the second member in both directions of one axis. By combining one member and the second member, the first partial flow path and the second partial flow path communicate with each other to form a flow path, and a combination of the first member and the second member is formed. By moving the second member in both directions of the one axis while maintaining, the combination of the communicating first partial flow path and the second partial flow path is changed to change the flow path to another flow path. A flow path switching mechanism that can be switched.
<2> A plurality of the second members are arranged in one row direction and combined with the first member, and at least one of the flow paths is configured such that the second partial flow paths of the plurality of second members are the first The flow path switching mechanism of <1> formed so as to communicate with each other through a part of the flow path.
<3> The second partial flow path is orthogonal to the one axis, and the first partial flow path is in communication with the second partial flow path and is at least one of two axes perpendicular to the one axis. The flow path switching mechanism of <1> or <2> that forms a flow path along the flow path.
<4> The flow path switching mechanism according to any one of <1> to <3>, wherein the driving force receiving portion includes a convex driving force receiving convex portion provided on the second member.
<5> The first member is a communication passage before movement that is the first partial flow passage that communicates with the second partial flow passage when the second member is in a predetermined position, and the second member is Any one of <1> to <4>, including a post-movement communication channel that is the first partial flow channel that communicates with the second partial flow channel when moving from a predetermined position along the axis. One flow path switching mechanism.
<6> The first member has a channel convex portion having a convex shape around an end portion of the first partial channel facing the outside, and the channel switching according to any one of <1> to <5>. mechanism.
<7> At least a part of the first member is a frame body, at least a part of the second member is fitted into the frame body, and the frame body is a reference strain portion having a predetermined rigidity, and the reference strain portion. The flow path switching mechanism according to any one of claims 1 to 6, further comprising: an easily strained portion having rigidity smaller than that of the strained portion.
<8> The flow path switching mechanism according to <7>, wherein at least a part of the easily strained portion has a thickness smaller than that of the reference strained portion.
<9> A material supply unit including a flow path switching mechanism according to <6> and a material container having a bottom surface that is broken by the flow path convex portion of the flow path switching mechanism.
<10> An insertion groove that holds the flow path switching mechanism of <2> and in which the flow path switching mechanism is inserted from at least one direction intersecting the row direction, and the flow path switching that is inserted into the insertion groove. A holder for a flow path switching mechanism, which has locking projections that are locked when the mechanism moves in the row direction.
<11> A drive unit that gives a drive force to the drive force receiving unit to move the second member of the flow channel switching mechanism according to any one of <1> to <8> in both directions of one axis, and the flow channel. A flow path switching mechanism holding receiver for holding the first member of the switching mechanism, wherein the flow path switching mechanism holding receiver is the first member while the second member is stationary and while the second member is moving. A flow path switching device that holds the flow path so that it does not move.
<12> The flow path switching device according to <11>, wherein a plurality of the second members are attached, and the drive unit includes a plurality of individual drive units that individually drive the second members.
<13> At least a part of the plurality of second members is arranged in one direction, the first member is combined with the plurality of second members, and the flow path switching mechanism holding portion receives the first member. The flow path switching device according to <11> or <12>, which includes a supporting base portion and an engaging portion formed on the base portion and engaging with the first member.
<14> The base portion has a length changing portion that changes the length of the base portion in the arrangement direction in which the first member is arranged,
The engaging portion formed on the base portion has an inclined portion that is inclined toward a moving direction that moves in accordance with a change in length by the length changing portion, and the length changing portion causes the engaging portion of the base portion to move. The flow path switching device according to <113>, wherein the engagement portion enters between the base portion and the first member when the length changes.
<15> The flow path switching mechanism installation body to which the flow path switching mechanism is attached is further provided, and the flow path switching mechanism installation body is integrated in a plurality of layers, and any one of <11> to <14>. Flow path switching device.
<16> The flow path switching device according to any one of <11> to <15>, in which the material supply unit of <9> is attached and used.
<17> The flow path switching device according to any one of <11> to <16>, further including a gas supply mechanism or a pressure reducing mechanism.
<18> The flow path switching device according to any one of <11> to <17>, further including at least one of a reaction container, a temperature control mechanism for the reaction container, a stirring mechanism for the reaction container, and a radiation detection mechanism.
<19> A bottomed container that contains a material used for chemical treatment, the container bottom part containing the material, and a bottom surface that seals the inside of the container body part. Is a material container including a fragile fragile portion at least in part.
<20> The material of <1>, wherein the bottom surface further includes a base portion that is more difficult to break than the weak portion together with the weak portion, and a connecting portion that connects the inner peripheral surface of the container body portion and the base portion. container.
<21> The material container according to <20>, wherein the fragile portion is made of a thin film, and the base portion is made of a thick film having a thickness larger than that of the fragile portion.
<22> The fragile portion is the material container according to <20> or <21>, which is arranged radially outside the bottom surface with respect to the base portion.
<23> The material container according to <21>, wherein the connecting portion is formed of the thick film that is continuous with the base portion.
<24> The container main body and the bottom surface have a circular shape in a top view, and the inner diameter of the container main body is larger than the diameter of the bottom surface, according to any one of <19> to <23>. Material container.
<25> In the container body, the bottom surface is provided at one end in the axial direction perpendicular to the bottom surface, the other end has an opening, and the opening is parallel to the bottom plate. The material container according to any one of <19> to <24>, further comprising: a lid part that is closed by means of; and a lid fixing mechanism that fixes the lid part to the container body part.
<26> The lid fixing mechanism includes a notch portion formed in the lid plate, an elastic piece connected to the container body, and a width of the notch portion provided at the tip of the elastic piece. A locking member having a larger portion, the elastic piece being held in the cutout portion and fixed to the outer surface of the lid plate by the locking member in a stretched state. 25> material container.
<27> The material container according to any one of <19> to <25>, a convex portion that breaks the fragile portion of the material container, and the convex portion inside the convex portion, and the convex portion is the fragile portion. A material supply unit, comprising: a receiving member having a flow path that is in communication with the material container in a state of being broken and inserted into the bottom surface.
<28> A flow path switching mechanism according to any one of <1> to <8>, and a bottomed material container for containing a material used for chemical treatment, wherein the material container contains the material. And a bottom surface that seals the inside of the container body portion, the bottom surface including a breakable fragile portion in at least a part thereof.
<29> The material according to <28>, wherein the bottom surface further includes a base portion that is more difficult to break than the weak portion together with the weak portion, and a connecting portion that connects the inner peripheral surface of the container body portion and the base portion. Supply unit.
<30> The material supply unit according to <29>, wherein the fragile portion is made of a thin film, and the base portion is made of a thick film having a thickness larger than that of the fragile portion.
<31> The material supply unit according to <29> or <30>, in which the fragile portion is arranged radially outside the bottom surface with respect to the base portion.
<32> The material supply unit according to <30>, wherein the connecting portion is formed of the thick film that is continuous with the base portion.
<33> The material supply unit according to any one of <28> to <32>, wherein the container body and the bottom surface have a circular shape in a top view, and the inner diameter of the container body is larger than the diameter of the bottom surface. ..
<34> In the container body, the bottom surface is provided at one end in the axial direction perpendicular to the bottom surface, the other end has an opening, and the opening is parallel to the bottom. The material supply unit according to any one of <28> to <33>, further including: a lid portion that is closed by means of; and a lid fixing mechanism that fixes the lid portion to the container body portion.
<35> The lid fixing mechanism includes a notch portion formed in the lid plate, an elastic piece connected to the container body, and a width of the notch portion provided at the tip of the elastic piece. A locking member having a larger portion, the elastic piece being held in the cutout portion and fixed to the outer surface of the lid plate by the locking member in a stretched state. 34> Material supply unit.
<36> The flow path switching mechanism includes a convex portion that breaks the fragile portion of the material container, and a convex portion that is inside the convex portion and that ruptures the fragile portion and is inserted into the bottom surface. A material supply unit according to any one of <28> to <35>, further comprising a receiving member having a flow path communicating with the material container in a state.
<37> A bottomed material container containing a chemical compound or a material used for synthesizing a drug, the container main body containing the material, and a bottom surface sealing the inside of the container main body. And, the container body has a first tubular portion having a tubular shape with a constant outer diameter and inner diameter, a second tubular portion having a constant outer diameter and inner diameter smaller than the first tubular portion, and It has a taper part which has a slope which connects the first cylinder part and the second cylinder part, and the bottom is the boundary of the taper part and the second cylinder part, and the taper of the second cylinder part. The fragile portion that is formed between the lower end portion on the opposite side of the portion and the fragile portion that is rupturable, the base portion that is less likely to break than the fragile portion, and the fragile portion that connects the inner peripheral surface of the container body portion and the base portion. And a connection portion that is more difficult to break than the weak portion, and the weak portion is formed of a thin film and is arranged in a part of a region outside the base portion on the bottom surface, and the base portion has a thickness larger than the thickness of the weak portion. A material container, comprising a thick film, wherein the connecting portion is formed of the thick film that is continuous with the base portion.
<38> A bottomed material container for containing a chemical compound or a material used for synthesizing a drug, the container body containing the material, and a bottom surface for sealing the inside of the container body. And, the bottom surface includes a fragile fragile portion in at least a part thereof, and the container main body portion is provided with the bottom surface at one end in an axial direction perpendicular to the bottom surface, and the other end. And a lid fixing mechanism that fixes the lid to the container body, the lid fixing mechanism comprising: A locking member having a notch formed on the lid plate, an elastic piece connected to the container body, and a portion larger than the width of the notch of the notch provided at the tip of the elastic piece. And the elastic piece is fixed to the outer surface of the lid plate in a stretched state by being held by the cutout portion and by the locking member.

This application includes Japanese application Japanese Patent Application No. 2017-90748, Japanese application Japanese Patent Application No. 2017-90749, and Japanese application Japanese Patent Application No. 2018-016544, which were filed on February 1, 2018, filed on April 28, 2017. Claim priority based on, and incorporate all of its disclosures here.

Claims (18)

A flow path switching mechanism for switching a flow path for circulating a material used for chemical treatment,
A first member in which one or more first partial flow paths are formed,
A second member that is combined with the first member in a movable state and has a plurality of or one second partial flow paths,
A driving force receiving portion that receives a driving force for moving the second member in both directions of one axis,
By combining the first member and the second member, the first partial flow path and the second partial flow path communicate with each other to form a flow path, and the first member and the second member By moving the second member in both directions of the one axis while maintaining the combination, the combination of the first partial flow path and the second partial flow path communicating with each other is changed and the flow path is changed to another flow path. A flow path switching mechanism that can be switched to a road. A plurality of the second members are arranged in one row direction and combined with the first member, and at least one of the flow paths is configured such that the second partial flow paths of the plurality of second members are the first partial flow paths. The flow path switching mechanism according to claim 1, wherein the flow path switching mechanism is formed so as to communicate with each other via. The second partial flow path is orthogonal to the one axis, and the first partial flow path is in communication with the second partial flow path and flows along at least one of two axes perpendicular to the one axis. The flow path switching mechanism according to claim 1, which forms a path. The flow path switching mechanism according to claim 1, wherein the driving force receiving portion includes a convex driving force receiving convex portion provided on the second member. The first member is a pre-movement communication channel that is the first partial flow channel that communicates with the second partial flow channel when the second member is at a predetermined position, and the second member is at the predetermined position. Flow path after movement, which is the first partial flow path communicating with the second partial flow path when moving along the axis from the flow path according to any one of claims 1 to 4. Road switching mechanism. The flow path switching mechanism according to claim 1, wherein the first member has a flow path convex portion having a convex shape around an end portion on the side facing the outside of the first partial flow path. At least a portion of the first member is a frame body, at least a portion of the second member is fitted into the frame body, the frame body is a reference strain portion having a predetermined rigidity, and the reference strain portion. 7. The flow path switching mechanism according to any one of claims 1 to 6, further comprising: an easily strained portion having low rigidity. A material supply unit including the flow path switching mechanism according to claim 6 and a material container having a bottom surface that is broken by the flow path convex portion of the flow path switching mechanism. A bottomed material container containing materials used for chemical processing,
A material container, comprising: a container body that contains the material; and a bottom surface that seals the interior of the container body, the bottom surface including a breakable fragile portion in at least a portion thereof. The material container according to claim 9, wherein the container body and the bottom surface have a circular shape in a top view, and the inner diameter of the container body is larger than the diameter of the bottom surface. The container body is provided with the bottom surface at one end in the axial direction perpendicular to the bottom surface, has an opening at the other end, and closes the opening with a lid plate parallel to the bottom. The material container according to claim 9 or 10, further comprising: a portion, and a lid fixing mechanism that fixes the lid portion to the container body portion. An insertion groove that holds the flow path switching mechanism according to claim 2 and into which the flow path switching mechanism is inserted from at least one direction intersecting the row direction, and the flow path switching mechanism that is inserted into the insertion groove. A holder for a flow path switching mechanism, which alternately has locking projections that lock by moving in the row direction. A drive unit that applies a drive force for moving the second member of the flow path switching mechanism according to any one of claims 1 to 7 in both directions of an axis, to the drive force receiving unit.
A flow path switching mechanism holding receiving portion that holds the first member of the flow path switching mechanism,
Equipped with
The flow path switching device holding portion holds the first member so that the first member does not move while the second member is stationary and while the second member is moving. The flow path switching device according to claim 13, wherein a plurality of the second members are attached, and the drive unit has a plurality of individual drive units that individually drive each of the second members. At least a part of the plurality of second members is arranged in one direction, the first member is combined with the plurality of second members,
15. The flow path switching mechanism holding receiver has a base portion that supports the first member, and an engagement portion that is formed on the base portion and that engages with the first member. Flow path switching device. The flow path according to any one of claims 13 to 15, further comprising a flow path switching mechanism installation body to which the flow path switching mechanism is attached, and the flow path switching mechanism installation body is integrated in a plurality of layers. Switching device. The flow path switching device according to claim 13, wherein the material supply unit according to claim 8 is attached and used. The flow path switching device according to claim 13, further comprising a gas supply mechanism or a pressure reducing mechanism.

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