WO2018193651A1 - Fragrance composition having male impulsiveness-controlling effect and relaxing effect - Google Patents
Fragrance composition having male impulsiveness-controlling effect and relaxing effect Download PDFInfo
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- WO2018193651A1 WO2018193651A1 PCT/JP2017/034207 JP2017034207W WO2018193651A1 WO 2018193651 A1 WO2018193651 A1 WO 2018193651A1 JP 2017034207 W JP2017034207 W JP 2017034207W WO 2018193651 A1 WO2018193651 A1 WO 2018193651A1
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
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- the present invention relates to a fragrance composition which is administered so as to be transmitted to the brain via the olfactory nerve and has an effect of improving concentration, such as continuous attention ability and selective attention ability, and impulsivity reduction in men. .
- concentration and impulsivity control are mainly borne by the prefrontal cortex. Many people drink many cups of energy drink, coffee or caffeinated soft drinks to increase their concentration. However, recently, the first domestic poisoning caused by poisoning occurred in Japan (2015/12/22 Kyodo News).
- Patent Document 2 discloses a composition that is a food and drink material but has a novel combination and has a concentration-improving effect and a relaxation-inducing action.
- Patent Document 1 uses a pepper extract and a ginger extract, there is a concern about the adverse effect on the digestive system, and Patent Document 2 has the same problem.
- the limbic system plays an important role in reacting quickly to powerful stimuli that cause emotions such as pleasure, pain, and fear.
- the hot system is always on, depending on the emotion at that moment, it can range from impulsive dying and eating to addiction (alcohol, smoking) and violent acts.
- the cool system interacts complementarily with the hot system of the brain. When one is activated, the other is suppressed.
- the cool system exists in the prefrontal cortex and can change the direction of attention and change the strategy flexibly as the situation changes. Coordinate thoughts and behaviors to activate cognitive, complex, thoughtful and slowly. Indispensable for future-oriented decision making and self-control efforts. However, strong stress suppresses the cool system and activates the hot system. Therefore, to achieve the best performance according to the purpose at hand, it is necessary to flexibly change the emphasis on these systems to improve concentration and impulsivity.
- the present invention is not limited to caffeine intake and foods and drinks that are highly irritating.
- a fragrance composition that controls the impulsivity by administering it so as to improve the concentration when the impulsivity is reduced by the oxidization and is transmitted from the nasal cavity or oral cavity to the brain via the olfactory nerve Objective.
- fragrance ingredients that provide “relaxed concentration” rather than “tensed concentration”.
- the inventor of the present invention contains, as an active ingredient, synthesized geraniol or geraniol isolated and purified from a natural product as an active ingredient. It was found that when administered so as to be transmitted to the brain via nerves, it has the effect of improving concentration and impulsiveness in men.
- the invention of claim 2 is the fragrance composition according to claim 1, wherein the geraniol or geraniol isolated and purified from a natural product is dissolved in a solvent at a ratio of 10 to 20 w / w with respect to the solvent. % Range.
- the synthesized geraniol of the present invention or geraniol isolated and purified from a natural product is contained as an active ingredient, and the oral cavity is provided to a man through the nasal cavity as a scent or as a food additive.
- the oral cavity is provided to a man through the nasal cavity as a scent or as a food additive.
- FIG. 2 is a graph showing the correlation between impulse (SSRT) and stress hormone cortisol.
- Each group of subjects was allowed to smell a solvent in which 15 w / w% of geraniol isolated and purified from a natural product was dissolved and only the solvent, and the impulsiveness (SSRT) was examined.
- the experiment was carried out by sending air to a glass bottle containing a solvent containing fragrance geraniol (propylene glycol: PG) at a flow rate of 2 L / min and releasing the air from the funnel 10 cm away from the subject's nose. This was continued for 20 minutes.
- subjects took a behavioral task by sitting on a chair and breathing as usual in a relaxed state. At this time, if any abnormality was observed, the experiment was stopped on the spot and appropriate measures were taken.
- the ratio of geraniol dissolved in a solvent such as propylene glycol (PG) is about 15 w / w% in this example, but it is preferably in the range of 10 to 20 w / w%. However, the odor is strong but the impulse suppressing effect is diminished, so about 15 w / w% is preferable.
- SST Simulse
- PG control
- SST Stem Signal Task
- the SST described above is a verification means devised for evaluating human impulsivity.
- a gaze point is displayed for 1000 ms in the center of the background.
- a right or left arrow is displayed at the center.
- the experiment consists of two types of stimulation conditions, Go trial and Stop trial. In the Go trial, the challenge is to answer the direction of the arrow as quickly and accurately as possible using the numeric keypad buttons.
- a stop signal is generated with a beep sound after a certain delay time. If a stop signal is presented, the subject is asked not to press any key.
- the delay time is initially set to 200 ms. If the reaction suppression is successful, the delay time of the next trial is increased by 50 ms. On the other hand, when the suppression fails, the delay time of the next trial is reduced by 50 ms. In this way, the delay time is changed for each trial and finally converges to the delay time accordingly.
- the value obtained by subtracting the average delay time of Stop Signal from the average reaction time of Go trial was used as an index of impulsiveness as Stop Signal Reaction Time (SSRT). Therefore, if SSRT is shortened, the impulsiveness is considered to be lowered.
- SSRT Stop Signal Reaction Time
- FIG. 1 (c) shows five female subjects in the luteal phase
- FIG. 1 (d) before and after smelling geraniol.
- the impulsiveness was examined by SSRT, but there was no significant difference (ns).
- Fig. 1 (a) shows that in the experimental results for 12 men, the impulsiveness was considered to be low because SSRT was shortened due to a significant difference of p ⁇ 0.04. It can be applied to improve the impulsivity.
- a composition containing synthesized geraniol or geraniol isolated and purified from a natural product as an active ingredient is transmitted to the brain via the olfactory nerve.
- the fragrance composition has the effect of improving concentration and reducing impulsivity when administered in such a way as to reduce traffic accidents caused by reduced concentration and impulsivity control especially for men. It is expected to be effective in improving concentration during study, reducing traffic accidents, overdose of caffeine for the purpose of improving concentration during work and study, and alleviating addictions such as smoking.
- composition for fragrance of the present invention (geraniol) is dissolved in geraniol in the examples, as long as the characteristics of the present invention are not impaired.
- the experiment was conducted by smelling the solvent through the nasal cavity, it only needs to act on the olfactory nerve and be transmitted to the brain. Of course, it may be transmitted to the network.
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Abstract
[Problem] To provide a fragrance composition which is efficacious in reducing traffic accidents caused by lowered control of male impulsiveness and improving mental concentration during working or studying, said fragrance composition neither containing caffeine nor being a pungent food or beverage. [Solution] A fragrance composition having effects of improving mental concentration and suppressing impulsiveness of males, said fragrance composition comprising geraniol, either synthesized or isolated and purified from a natural material, as an active ingredient and being to be administered in such a manner that the geraniol is transmitted to the brain through the olfactory nerve from the nasal cavity or, when used in the form of a food additive, from the oral cavity.
Description
本発明は、嗅覚神経を介して脳に伝達されるように投与して、男性の持続的注意能力や選択的注意能力等の集中力向上や、衝動性低下の作用を有する芳香用組成物に関する。
The present invention relates to a fragrance composition which is administered so as to be transmitted to the brain via the olfactory nerve and has an effect of improving concentration, such as continuous attention ability and selective attention ability, and impulsivity reduction in men. .
一般に、車の運転、受験勉強、仕事（作業、交渉等）など、その時々の目的に応じた行動をとるには、重要な情報に注意を払い（集中力）、不必要な行動・気が散るような考えを抑制する（衝動性制御）必要がある。
集中力と衝動性制御の脳内メカニズムについては、集中力、衝動性制御は主に前頭前野に担われているいることが知られている。
多くの人々は集中力を高めようとしてコーヒーやカフェイン入り清涼飲料水「エナジードリンク」を何杯も飲むことが多い。しかし、最近、国内初のエナジードリンク常用による中毒死が起こった（2015/12/22 共同通信）。米国では、エナジードリンクが原因と疑われる死亡例がこれまでに３０件以上報告されており、エナジードリンクを飲んだ後に、心臓発作や不整脈などの症状で医療施設の救急室に運び込まれた患者が、２０１１年だけで約２０,７００人いると伝えている。
このように、従来、集中力を高める為には、カフェインの摂取が行われていたが、近年、カフェインの過剰摂取の危険性が報告されるようになった。 In general, pay attention to important information (concentration) and take unnecessary actions / feelings in order to take action according to the purpose of the occasion, such as driving a car, studying for an examination, work (work, negotiation, etc.) It is necessary to suppress distracting ideas (impulsiveness control).
Concerning brain mechanisms of concentration and impulsivity control, it is known that concentration and impulsivity control are mainly borne by the prefrontal cortex.
Many people drink many cups of energy drink, coffee or caffeinated soft drinks to increase their concentration. However, recently, the first domestic poisoning caused by poisoning occurred in Japan (2015/12/22 Kyodo News). In the United States, more than 30 deaths suspected of being caused by energy drinks have been reported so far, and after taking energy drinks, some patients were brought into the emergency room of a medical facility due to symptoms such as a heart attack or arrhythmia. In 2011 alone, there are about 20,700 people.
Thus, in order to increase concentration, caffeine has been ingested in the past, but in recent years, the danger of excessive intake of caffeine has been reported.
集中力と衝動性制御の脳内メカニズムについては、集中力、衝動性制御は主に前頭前野に担われているいることが知られている。
多くの人々は集中力を高めようとしてコーヒーやカフェイン入り清涼飲料水「エナジードリンク」を何杯も飲むことが多い。しかし、最近、国内初のエナジードリンク常用による中毒死が起こった（2015/12/22 共同通信）。米国では、エナジードリンクが原因と疑われる死亡例がこれまでに３０件以上報告されており、エナジードリンクを飲んだ後に、心臓発作や不整脈などの症状で医療施設の救急室に運び込まれた患者が、２０１１年だけで約２０,７００人いると伝えている。
このように、従来、集中力を高める為には、カフェインの摂取が行われていたが、近年、カフェインの過剰摂取の危険性が報告されるようになった。 In general, pay attention to important information (concentration) and take unnecessary actions / feelings in order to take action according to the purpose of the occasion, such as driving a car, studying for an examination, work (work, negotiation, etc.) It is necessary to suppress distracting ideas (impulsiveness control).
Concerning brain mechanisms of concentration and impulsivity control, it is known that concentration and impulsivity control are mainly borne by the prefrontal cortex.
Many people drink many cups of energy drink, coffee or caffeinated soft drinks to increase their concentration. However, recently, the first domestic poisoning caused by poisoning occurred in Japan (2015/12/22 Kyodo News). In the United States, more than 30 deaths suspected of being caused by energy drinks have been reported so far, and after taking energy drinks, some patients were brought into the emergency room of a medical facility due to symptoms such as a heart attack or arrhythmia. In 2011 alone, there are about 20,700 people.
Thus, in order to increase concentration, caffeine has been ingested in the past, but in recent years, the danger of excessive intake of caffeine has been reported.
カフェイン摂取以外の方法で集中力、衝動性を制御することについては、特許文献１のトウガラシ抽出物及びショウガ抽出物の一方又は両方と、テアニンとを含有する組成物を経口摂取することにより、眠気が抑制され、集中力が高まり、且つ、これらの作用が長期間持続することができることが開示されている。
また、特許文献２には、飲食物材料でありながら、その組み合わせが新規であって、集中力向上効果やリラックス喚起作用を有する組成物が開示されている。 For controlling concentration and impulsivity by methods other than caffeine intake, by orally ingesting a composition containing one or both of the pepper extract and ginger extract ofPatent Document 1 and theanine, It is disclosed that drowsiness is suppressed, concentration is enhanced, and that these actions can last for a long time.
Further, Patent Document 2 discloses a composition that is a food and drink material but has a novel combination and has a concentration-improving effect and a relaxation-inducing action.
また、特許文献２には、飲食物材料でありながら、その組み合わせが新規であって、集中力向上効果やリラックス喚起作用を有する組成物が開示されている。 For controlling concentration and impulsivity by methods other than caffeine intake, by orally ingesting a composition containing one or both of the pepper extract and ginger extract of
Further, Patent Document 2 discloses a composition that is a food and drink material but has a novel combination and has a concentration-improving effect and a relaxation-inducing action.
前掲の特許文献１はトウガラシ抽出物及びショウガ抽出物を使用することから、消化器系に悪影響が懸念され、特許文献２も同様の問題点があった。
有史以前に、人類が生存できたのは脳のホットシステムである大脳辺縁系のおかげである。大脳辺縁系は快感、苦痛、恐れといった情動を引き起こす強力な刺激に素早い反応することに重要な役割を果たす。しかし、ホットなシステムが常にオン担っていると、その瞬間瞬間の情動に応じ、衝動的な暴飲暴食から嗜癖（アルコール、喫煙）や暴力行為等にも至る。脳のホットシステムと相補的に相互作用を持つのがクールシステムである。一方が活性化するともう一方は抑制される。クールシステムは前頭前皮質に存在し、状況の変化に伴って刻々と注意の方向を転換し、柔軟に戦略を変更できる。思考や行動を調整し、認知的で、複雑で、思慮深く、ゆっくり活性化する。未来志向の意思決定と自制の努力に欠かせない。しかし、強いストレスはクールシステムを抑制し、ホットシステムを活性化する。
したがって、その時々の目的に応じて最高のパフォーマンスを達成するには、これらのシステムへの重点を柔軟に変動させ、集中力の向上や衝動性を低下させる必要がある。 Since the above-mentionedPatent Document 1 uses a pepper extract and a ginger extract, there is a concern about the adverse effect on the digestive system, and Patent Document 2 has the same problem.
Before history, mankind was able to survive thanks to the limbic system, the hot system of the brain. The limbic system plays an important role in reacting quickly to powerful stimuli that cause emotions such as pleasure, pain, and fear. However, if the hot system is always on, depending on the emotion at that moment, it can range from impulsive dying and eating to addiction (alcohol, smoking) and violent acts. The cool system interacts complementarily with the hot system of the brain. When one is activated, the other is suppressed. The cool system exists in the prefrontal cortex and can change the direction of attention and change the strategy flexibly as the situation changes. Coordinate thoughts and behaviors to activate cognitive, complex, thoughtful and slowly. Indispensable for future-oriented decision making and self-control efforts. However, strong stress suppresses the cool system and activates the hot system.
Therefore, to achieve the best performance according to the purpose at hand, it is necessary to flexibly change the emphasis on these systems to improve concentration and impulsivity.
有史以前に、人類が生存できたのは脳のホットシステムである大脳辺縁系のおかげである。大脳辺縁系は快感、苦痛、恐れといった情動を引き起こす強力な刺激に素早い反応することに重要な役割を果たす。しかし、ホットなシステムが常にオン担っていると、その瞬間瞬間の情動に応じ、衝動的な暴飲暴食から嗜癖（アルコール、喫煙）や暴力行為等にも至る。脳のホットシステムと相補的に相互作用を持つのがクールシステムである。一方が活性化するともう一方は抑制される。クールシステムは前頭前皮質に存在し、状況の変化に伴って刻々と注意の方向を転換し、柔軟に戦略を変更できる。思考や行動を調整し、認知的で、複雑で、思慮深く、ゆっくり活性化する。未来志向の意思決定と自制の努力に欠かせない。しかし、強いストレスはクールシステムを抑制し、ホットシステムを活性化する。
したがって、その時々の目的に応じて最高のパフォーマンスを達成するには、これらのシステムへの重点を柔軟に変動させ、集中力の向上や衝動性を低下させる必要がある。 Since the above-mentioned
Before history, mankind was able to survive thanks to the limbic system, the hot system of the brain. The limbic system plays an important role in reacting quickly to powerful stimuli that cause emotions such as pleasure, pain, and fear. However, if the hot system is always on, depending on the emotion at that moment, it can range from impulsive dying and eating to addiction (alcohol, smoking) and violent acts. The cool system interacts complementarily with the hot system of the brain. When one is activated, the other is suppressed. The cool system exists in the prefrontal cortex and can change the direction of attention and change the strategy flexibly as the situation changes. Coordinate thoughts and behaviors to activate cognitive, complex, thoughtful and slowly. Indispensable for future-oriented decision making and self-control efforts. However, strong stress suppresses the cool system and activates the hot system.
Therefore, to achieve the best performance according to the purpose at hand, it is necessary to flexibly change the emphasis on these systems to improve concentration and impulsivity.
本発明は、カフェイン過剰摂取を避けるために、カフェイン摂取以外で、かつ、刺激が強い飲食物以外で、特に、ホットシステム活性化による男性の素早い反応性を持ちつつも、クールシステムの活性化による衝動性低下での集中力の向上がなされるようにし、鼻腔や口腔から嗅覚神経を介して脳に伝達されるように投与して衝動性を制御する芳香用組成物を提供することを目的とする。「緊張した集中」ではなく、「リラックスした集中」もたらす芳香成分を提供する。
In order to avoid excessive intake of caffeine, the present invention is not limited to caffeine intake and foods and drinks that are highly irritating. To provide a fragrance composition that controls the impulsivity by administering it so as to improve the concentration when the impulsivity is reduced by the oxidization and is transmitted from the nasal cavity or oral cavity to the brain via the olfactory nerve Objective. Provide fragrance ingredients that provide “relaxed concentration” rather than “tensed concentration”.
本発明者は、上記課題を解決するため鋭意検討を重ねた結果、請求項１の発明は、合成されたゲラニオール、又は、天然物から単離・精製されたゲラニオールを有効成分として含有し、嗅覚神経を介して脳に伝達されるように投与すると、男性の集中力向上・衝動性低下の作用を有することを見出した。
請求項２の発明は、請求項１に記載の芳香用組成物において、前記ゲラニオール、又は、天然物から単離・精製されたゲラニオールは、溶媒に溶かす比率は溶媒に対して１０～２０w/w％の範囲とすることを特徴とする。 As a result of intensive studies to solve the above-mentioned problems, the inventor of the present invention contains, as an active ingredient, synthesized geraniol or geraniol isolated and purified from a natural product as an active ingredient. It was found that when administered so as to be transmitted to the brain via nerves, it has the effect of improving concentration and impulsiveness in men.
The invention of claim 2 is the fragrance composition according toclaim 1, wherein the geraniol or geraniol isolated and purified from a natural product is dissolved in a solvent at a ratio of 10 to 20 w / w with respect to the solvent. % Range.
請求項２の発明は、請求項１に記載の芳香用組成物において、前記ゲラニオール、又は、天然物から単離・精製されたゲラニオールは、溶媒に溶かす比率は溶媒に対して１０～２０w/w％の範囲とすることを特徴とする。 As a result of intensive studies to solve the above-mentioned problems, the inventor of the present invention contains, as an active ingredient, synthesized geraniol or geraniol isolated and purified from a natural product as an active ingredient. It was found that when administered so as to be transmitted to the brain via nerves, it has the effect of improving concentration and impulsiveness in men.
The invention of claim 2 is the fragrance composition according to
本発明の合成された合成されたゲラニオール、又は、天然物から単離・精製されたゲラニオールを有効成分として含有し、男性に対して、香として鼻腔を介して、或いは、食品添加物として口腔を介して嗅覚神経を介して脳に伝達されるように投与すると、ホットシステム活性化による持続的注意能力、選択的注意能力の集中力向上や、クールシステムの活性化による衝動性低下の作用を有するので、集中力や衝動性制御の低下に伴い生じる、交通事故の低減、業務中、勉強中の集中力の向上、またそれら目的としたカフェインの過剰摂取、喫煙の嗜癖を緩和する効果が期待できる。
The synthesized geraniol of the present invention or geraniol isolated and purified from a natural product is contained as an active ingredient, and the oral cavity is provided to a man through the nasal cavity as a scent or as a food additive. When administered to be transmitted to the brain via the olfactory nerve, it has the effect of improving the attentional ability of continuous attention by selective activation of hot system, the concentration of selective attention ability, and the impulsivity reduction by activation of cool system. Therefore, it is expected to reduce traffic accidents caused by a decline in concentration and impulsiveness control, improve concentration during work and study, and to reduce excessive intake of caffeine and smoking addiction for those purposes. it can.
以下、本発明を詳細に説明するが、実施例にしたがって説明する。
先ず、男性については、精神的・身体的に健常な２０代から３０代の成人男性、女性については、正常月経周期(２６日～３４日)を回帰する精神的・身体的に健常な２０代の非喫煙女性を対象として、ゲラニオールを嗅いだ場合に生じる集中力、衝動性の変化を調べた。 The present invention will be described in detail below, but will be described according to examples.
First, for men, adult men in their 20s to 30s who are mentally and physically healthy, and for men, who are mentally and physically healthy in their 20s who return to the normal menstrual cycle (26th to 34th) Changes in concentration and impulsivity that occur when geraniol was sniffed were studied in non-smoking women.
先ず、男性については、精神的・身体的に健常な２０代から３０代の成人男性、女性については、正常月経周期(２６日～３４日)を回帰する精神的・身体的に健常な２０代の非喫煙女性を対象として、ゲラニオールを嗅いだ場合に生じる集中力、衝動性の変化を調べた。 The present invention will be described in detail below, but will be described according to examples.
First, for men, adult men in their 20s to 30s who are mentally and physically healthy, and for men, who are mentally and physically healthy in their 20s who return to the normal menstrual cycle (26th to 34th) Changes in concentration and impulsivity that occur when geraniol was sniffed were studied in non-smoking women.
[ゲラニオール(Geraniol)]の作用・効果の実験
１.実験方法
１－１.説明会
被験者には、事前に実験内容を説明して承諾を得てから、実験当日は匂いが強い食べ物や刺激物(ニンニク・タマネギ・香辛料・香草など)を朝から食べないようにし、実験開始３０分前からは何も食べないようにしてもらうようにした。また、女性被験者に対しては基礎体温を記載してもらい、排卵検査薬を用いて、排卵日(ＬＨサージ)を確定してもらった。
１－２.実験当日
成人男性を１２人、女性被験者を月経周期により、卵胞期(月経開始後５－１０日)９人、黄体後期(ＬＨサージ後９－１２日 )５人、通常状態の成人女性７人の３グループを分けた。各々のグループの被験者に、天然物から単離・精製されたゲラニオールの１５w/w％を溶かした溶媒と、溶媒のみとを嗅いがせ、その際の衝動性(ＳＳＲＴ)を調べた。
実験は、空気を２L/minの風量で香料ゲラニオールを含む溶媒(プロピレン グリコール：ＰＧ)の入ったガラス瓶に送り、そこから出てきた空気を被験者の鼻から１０cm 離したロートから放出させることにより行い、これを２０分間続けた。実験中は、被験者には椅子に座ってリラックスした状態で普段と変わらない呼吸をしてもらい、行動課題を実施した。このとき、何らかの異常を認めた場合、その場で実験を中止し適切な処置を行うこととした。
なお、ゲラニオールのプロピレン グリコール（ＰＧ)等の溶媒に溶かす比率は本実施例では１５w/w％程度としたが、１０～２０w/w％の範囲がよく、あまり薄いと効果がなく、あまり濃くても匂いは強くなるが衝動抑制効果が薄れるので、１５ｗ/ｗ％程度が好ましい。 Experiments on the effects and effects of [Geraniol] 1. Experimental method 1-1. Briefing session The subjects explained the contents of the experiment in advance and obtained their consent. (Garlic, onion, spices, herbs, etc.) were not eaten from the morning, and no food was eaten 30 minutes before the start of the experiment. In addition, female subjects were asked to describe their basal body temperature, and the ovulation day (LH surge) was confirmed using an ovulation test.
1-2. On the day of theexperiment 12 adult men, 9 female subjects in the menstrual cycle, 9 in the follicular phase (5-10 days after the start of menstruation), 5 in the late corpus luteum (9-12 days after the LH surge), We divided three groups of seven adult women. Each group of subjects was allowed to smell a solvent in which 15 w / w% of geraniol isolated and purified from a natural product was dissolved and only the solvent, and the impulsiveness (SSRT) was examined.
The experiment was carried out by sending air to a glass bottle containing a solvent containing fragrance geraniol (propylene glycol: PG) at a flow rate of 2 L / min and releasing the air from the funnel 10 cm away from the subject's nose. This was continued for 20 minutes. During the experiment, subjects took a behavioral task by sitting on a chair and breathing as usual in a relaxed state. At this time, if any abnormality was observed, the experiment was stopped on the spot and appropriate measures were taken.
The ratio of geraniol dissolved in a solvent such as propylene glycol (PG) is about 15 w / w% in this example, but it is preferably in the range of 10 to 20 w / w%. However, the odor is strong but the impulse suppressing effect is diminished, so about 15 w / w% is preferable.
１.実験方法
１－１.説明会
被験者には、事前に実験内容を説明して承諾を得てから、実験当日は匂いが強い食べ物や刺激物(ニンニク・タマネギ・香辛料・香草など)を朝から食べないようにし、実験開始３０分前からは何も食べないようにしてもらうようにした。また、女性被験者に対しては基礎体温を記載してもらい、排卵検査薬を用いて、排卵日(ＬＨサージ)を確定してもらった。
１－２.実験当日
成人男性を１２人、女性被験者を月経周期により、卵胞期(月経開始後５－１０日)９人、黄体後期(ＬＨサージ後９－１２日 )５人、通常状態の成人女性７人の３グループを分けた。各々のグループの被験者に、天然物から単離・精製されたゲラニオールの１５w/w％を溶かした溶媒と、溶媒のみとを嗅いがせ、その際の衝動性(ＳＳＲＴ)を調べた。
実験は、空気を２L/minの風量で香料ゲラニオールを含む溶媒(プロピレン グリコール：ＰＧ)の入ったガラス瓶に送り、そこから出てきた空気を被験者の鼻から１０cm 離したロートから放出させることにより行い、これを２０分間続けた。実験中は、被験者には椅子に座ってリラックスした状態で普段と変わらない呼吸をしてもらい、行動課題を実施した。このとき、何らかの異常を認めた場合、その場で実験を中止し適切な処置を行うこととした。
なお、ゲラニオールのプロピレン グリコール（ＰＧ)等の溶媒に溶かす比率は本実施例では１５w/w％程度としたが、１０～２０w/w％の範囲がよく、あまり薄いと効果がなく、あまり濃くても匂いは強くなるが衝動抑制効果が薄れるので、１５ｗ/ｗ％程度が好ましい。 Experiments on the effects and effects of [Geraniol] 1. Experimental method 1-1. Briefing session The subjects explained the contents of the experiment in advance and obtained their consent. (Garlic, onion, spices, herbs, etc.) were not eaten from the morning, and no food was eaten 30 minutes before the start of the experiment. In addition, female subjects were asked to describe their basal body temperature, and the ovulation day (LH surge) was confirmed using an ovulation test.
1-2. On the day of the
The experiment was carried out by sending air to a glass bottle containing a solvent containing fragrance geraniol (propylene glycol: PG) at a flow rate of 2 L / min and releasing the air from the funnel 10 cm away from the subject's nose. This was continued for 20 minutes. During the experiment, subjects took a behavioral task by sitting on a chair and breathing as usual in a relaxed state. At this time, if any abnormality was observed, the experiment was stopped on the spot and appropriate measures were taken.
The ratio of geraniol dissolved in a solvent such as propylene glycol (PG) is about 15 w / w% in this example, but it is preferably in the range of 10 to 20 w / w%. However, the odor is strong but the impulse suppressing effect is diminished, so about 15 w / w% is preferable.
上記の[衝動性（ＳＳＲＴ）]は、以下の内容で検証する。
「衝動性」の検証には、PC操作による認知課題であるＳＳＴ(Stop Signal Task)を用いて、香料を嗅いだ前後の集中力の変化をＰＧ(コントロール )の場合と比較を行った。
前述したＳＳＴは、ヒトの衝動性を評価するために考案された検証手段である。ＳＳＴでは、実験トライアルが開始されると、背景の中央に注視点が１０００ms表示される。次に、中央に右または左向き矢印が表示される。実験は、Go試行とStop試行の２種の刺激条件から構成される。Go試行では、矢印の向きをテンキーのボタンでできるだけ素早くかつ正確に回答することが課題である。Stop試行では矢印呈示後、一定の遅延時間を挟み、ビープ音によるStop Signal（停止信号）が呈示される。Stop signalが呈示された場合、被験者はいずれのキーも押さないように求められる。遅延時間は始めに２００msに設定され、反応抑制に成功すると次試行の遅延時間が５０msずつ長くなる。一方、抑制に失敗した場合は次試行の遅延時間が５０msずつ短縮される。このように遅延時間を試行ごとに変動させ、最終的にはしかるべく遅延時間へと収束する。本実験では、Go試行の平均反応時間からStop Signalの平均遅延時間を引いた値をStop Signal Reaction Time (ＳＳＲＴ)とし、衝動性の指標として用いた。
したがって、ＳＳＲＴが短縮すれば、衝動性が低くなったものと考えられる。 The above [Impulse (SSRT)] will be verified as follows.
For verification of “impulsiveness”, the change in concentration before and after smelling a fragrance was compared with that of PG (control) using SST (Stop Signal Task) which is a cognitive task by PC operation.
The SST described above is a verification means devised for evaluating human impulsivity. In SST, when an experimental trial is started, a gaze point is displayed for 1000 ms in the center of the background. Next, a right or left arrow is displayed at the center. The experiment consists of two types of stimulation conditions, Go trial and Stop trial. In the Go trial, the challenge is to answer the direction of the arrow as quickly and accurately as possible using the numeric keypad buttons. In the Stop trial, after presenting an arrow, a stop signal is generated with a beep sound after a certain delay time. If a stop signal is presented, the subject is asked not to press any key. The delay time is initially set to 200 ms. If the reaction suppression is successful, the delay time of the next trial is increased by 50 ms. On the other hand, when the suppression fails, the delay time of the next trial is reduced by 50 ms. In this way, the delay time is changed for each trial and finally converges to the delay time accordingly. In this experiment, the value obtained by subtracting the average delay time of Stop Signal from the average reaction time of Go trial was used as an index of impulsiveness as Stop Signal Reaction Time (SSRT).
Therefore, if SSRT is shortened, the impulsiveness is considered to be lowered.
「衝動性」の検証には、PC操作による認知課題であるＳＳＴ(Stop Signal Task)を用いて、香料を嗅いだ前後の集中力の変化をＰＧ(コントロール )の場合と比較を行った。
前述したＳＳＴは、ヒトの衝動性を評価するために考案された検証手段である。ＳＳＴでは、実験トライアルが開始されると、背景の中央に注視点が１０００ms表示される。次に、中央に右または左向き矢印が表示される。実験は、Go試行とStop試行の２種の刺激条件から構成される。Go試行では、矢印の向きをテンキーのボタンでできるだけ素早くかつ正確に回答することが課題である。Stop試行では矢印呈示後、一定の遅延時間を挟み、ビープ音によるStop Signal（停止信号）が呈示される。Stop signalが呈示された場合、被験者はいずれのキーも押さないように求められる。遅延時間は始めに２００msに設定され、反応抑制に成功すると次試行の遅延時間が５０msずつ長くなる。一方、抑制に失敗した場合は次試行の遅延時間が５０msずつ短縮される。このように遅延時間を試行ごとに変動させ、最終的にはしかるべく遅延時間へと収束する。本実験では、Go試行の平均反応時間からStop Signalの平均遅延時間を引いた値をStop Signal Reaction Time (ＳＳＲＴ)とし、衝動性の指標として用いた。
したがって、ＳＳＲＴが短縮すれば、衝動性が低くなったものと考えられる。 The above [Impulse (SSRT)] will be verified as follows.
For verification of “impulsiveness”, the change in concentration before and after smelling a fragrance was compared with that of PG (control) using SST (Stop Signal Task) which is a cognitive task by PC operation.
The SST described above is a verification means devised for evaluating human impulsivity. In SST, when an experimental trial is started, a gaze point is displayed for 1000 ms in the center of the background. Next, a right or left arrow is displayed at the center. The experiment consists of two types of stimulation conditions, Go trial and Stop trial. In the Go trial, the challenge is to answer the direction of the arrow as quickly and accurately as possible using the numeric keypad buttons. In the Stop trial, after presenting an arrow, a stop signal is generated with a beep sound after a certain delay time. If a stop signal is presented, the subject is asked not to press any key. The delay time is initially set to 200 ms. If the reaction suppression is successful, the delay time of the next trial is increased by 50 ms. On the other hand, when the suppression fails, the delay time of the next trial is reduced by 50 ms. In this way, the delay time is changed for each trial and finally converges to the delay time accordingly. In this experiment, the value obtained by subtracting the average delay time of Stop Signal from the average reaction time of Go trial was used as an index of impulsiveness as Stop Signal Reaction Time (SSRT).
Therefore, if SSRT is shortened, the impulsiveness is considered to be lowered.
ＳＳＲＴ実験方法によって、成人男性、卵胞期の女性被験者、黄体期の女性被験者、通常状態の女性を対象に、天然物から単離・精製されたゲラニオールの１５w/w％を溶かした溶媒と、溶媒のみとを嗅いだ際の衝動性(ＳＳＲＴ)を調べ、その結果を図１に示して説明する。
ＳＳＴにおけるGo試行の平均反応時間からStop Signalの平均遅延時間を引いた値をStop Signal Reaction Time (ＳＳＲＴ)とし、衝動性の指標として用いた。ＳＳＲＴが長いほど衝動的であることを意味する。
これらの実験結果が図１のグラフである。ゲラニオールを嗅いだ前後で、コントロール(ＰＧ)に比べたもので、図１(ｂ)は卵胞期の女性被験者９人、図１(ｃ)は黄体期の女性被験者５人、図１(ｄ)に対象に、ＳＳＲＴで衝動性を調べたが、何れも有意差がなかった(n.s)。
しかし、図１(ａ)は、男性１２人を対象にした実験結果では、p＜0.04 の有意差で、ＳＳＲＴが短縮した為、衝動性が低くなったものと考えられ、これらの結果から男性の衝動性の改善に適用可能である。 According to the SSRT experimental method, a solvent in which 15 w / w% of geraniol isolated and purified from a natural product was dissolved in an adult male, a female subject in the follicular stage, a female subject in the luteal phase, and a normal female, The impulsiveness (SSRT) when sniffing is investigated, and the result is shown in FIG.
A value obtained by subtracting the average delay time of Stop Signal from the average reaction time of Go trial in SST was used as an index of impulsiveness as Stop Signal Reaction Time (SSRT). A longer SSRT means more impulsive.
The results of these experiments are the graph of FIG. FIG. 1 (b) shows nine female subjects in the follicular phase, FIG. 1 (c) shows five female subjects in the luteal phase, and FIG. 1 (d) before and after smelling geraniol. In the subjects, the impulsiveness was examined by SSRT, but there was no significant difference (ns).
However, Fig. 1 (a) shows that in the experimental results for 12 men, the impulsiveness was considered to be low because SSRT was shortened due to a significant difference of p <0.04. It can be applied to improve the impulsivity.
ＳＳＴにおけるGo試行の平均反応時間からStop Signalの平均遅延時間を引いた値をStop Signal Reaction Time (ＳＳＲＴ)とし、衝動性の指標として用いた。ＳＳＲＴが長いほど衝動的であることを意味する。
これらの実験結果が図１のグラフである。ゲラニオールを嗅いだ前後で、コントロール(ＰＧ)に比べたもので、図１(ｂ)は卵胞期の女性被験者９人、図１(ｃ)は黄体期の女性被験者５人、図１(ｄ)に対象に、ＳＳＲＴで衝動性を調べたが、何れも有意差がなかった(n.s)。
しかし、図１(ａ)は、男性１２人を対象にした実験結果では、p＜0.04 の有意差で、ＳＳＲＴが短縮した為、衝動性が低くなったものと考えられ、これらの結果から男性の衝動性の改善に適用可能である。 According to the SSRT experimental method, a solvent in which 15 w / w% of geraniol isolated and purified from a natural product was dissolved in an adult male, a female subject in the follicular stage, a female subject in the luteal phase, and a normal female, The impulsiveness (SSRT) when sniffing is investigated, and the result is shown in FIG.
A value obtained by subtracting the average delay time of Stop Signal from the average reaction time of Go trial in SST was used as an index of impulsiveness as Stop Signal Reaction Time (SSRT). A longer SSRT means more impulsive.
The results of these experiments are the graph of FIG. FIG. 1 (b) shows nine female subjects in the follicular phase, FIG. 1 (c) shows five female subjects in the luteal phase, and FIG. 1 (d) before and after smelling geraniol. In the subjects, the impulsiveness was examined by SSRT, but there was no significant difference (ns).
However, Fig. 1 (a) shows that in the experimental results for 12 men, the impulsiveness was considered to be low because SSRT was shortened due to a significant difference of p <0.04. It can be applied to improve the impulsivity.
また、ゲラニオール(Geraniol)について、唾液中のコーチゾール実験方法によって、成人男性を対象に、天然物から単離・精製されたゲラニオールの１５w/w％を溶かした溶媒を嗅いだ前後と、溶媒のみとを嗅いだ前後の唾液中のコーチゾール濃度を調べ、嗅いだ前後のコーチゾール変化量とＳＳＲＴの関係を図２に示して説明する。
ゲラニオールの１５ｗ/ｗ％を溶かした溶媒を嗅いだ前後のコーチゾール変化量とＳＳＲＴは相関を示した。ところが、溶媒のみを嗅いだ前後の唾液中のコーチゾール変化量とＳＳＲＴは相関しなかった。このことから、ゲラニオールの匂いを嗅ぐことによって、ストレスの減弱に伴って衝動性の低下が見られることがわかった。 In addition, with regard to geraniol, by using the cortisol experiment method in saliva, for adult males, before and after smelling a solvent dissolved in 15% w / w of geraniol isolated and purified from natural products, only the solvent The cortisol concentration in the saliva before and after sniffing is examined, and the relationship between the amount of cortisol change before and after sniffing and SSRT is shown in FIG.
The amount of change in cortisol before and after smelling a solvent in which 15 w / w% of geraniol was dissolved was correlated with SSRT. However, the amount of cortisol change in saliva before and after smelling only the solvent did not correlate with SSRT. From this, it was found that impulsiveness was reduced with the decrease in stress by smelling geraniol.
ゲラニオールの１５ｗ/ｗ％を溶かした溶媒を嗅いだ前後のコーチゾール変化量とＳＳＲＴは相関を示した。ところが、溶媒のみを嗅いだ前後の唾液中のコーチゾール変化量とＳＳＲＴは相関しなかった。このことから、ゲラニオールの匂いを嗅ぐことによって、ストレスの減弱に伴って衝動性の低下が見られることがわかった。 In addition, with regard to geraniol, by using the cortisol experiment method in saliva, for adult males, before and after smelling a solvent dissolved in 15% w / w of geraniol isolated and purified from natural products, only the solvent The cortisol concentration in the saliva before and after sniffing is examined, and the relationship between the amount of cortisol change before and after sniffing and SSRT is shown in FIG.
The amount of change in cortisol before and after smelling a solvent in which 15 w / w% of geraniol was dissolved was correlated with SSRT. However, the amount of cortisol change in saliva before and after smelling only the solvent did not correlate with SSRT. From this, it was found that impulsiveness was reduced with the decrease in stress by smelling geraniol.
以上説明したように、本発明の実施例によれば、合成されたゲラニオール、又は天然物から単離・精製されたゲラニオールを有効成分として含有する組成物を、嗅覚神経を介して脳に伝達されるように投与すると集中力向上・衝動性低下の作用を有する芳香用組成物であるので、特に、男性に対応して集中力や、衝動性制御の低下に伴い生じる交通事故の低減、業務中、勉強中の集中力の向上、また交通事故の低減、業務中、勉強中の集中力の向上を目的としたカフェインの過剰摂取、喫煙などの嗜癖を緩和する効果が期待できる。
As described above, according to the embodiments of the present invention, a composition containing synthesized geraniol or geraniol isolated and purified from a natural product as an active ingredient is transmitted to the brain via the olfactory nerve. The fragrance composition has the effect of improving concentration and reducing impulsivity when administered in such a way as to reduce traffic accidents caused by reduced concentration and impulsivity control especially for men. It is expected to be effective in improving concentration during study, reducing traffic accidents, overdose of caffeine for the purpose of improving concentration during work and study, and alleviating addictions such as smoking.
なお、本発明の特徴を損なうものでなければ、上記実施例に限定されるものでないことは勿論であり、本発明の芳香用組成物(ゲラニオール)は、例えば、実施例では、ゲラニオールを溶かした溶媒を鼻腔を介して嗅いで実験したが、嗅覚神経に作用させ脳に伝達されるのであればよく、鼻腔を介して嗅ぐ以外にも、食品添加物として口腔を介して嗅覚神経に作用させ脳に伝達される方法でもよいことは勿論である。
Of course, the composition for fragrance of the present invention (geraniol) is dissolved in geraniol in the examples, as long as the characteristics of the present invention are not impaired. Although the experiment was conducted by smelling the solvent through the nasal cavity, it only needs to act on the olfactory nerve and be transmitted to the brain. Of course, it may be transmitted to the network.
Claims (2)
- 合成されたゲラニオール、又は、天然物から単離・精製されたゲラニオールを有効成分として含有し、嗅覚神経を介して脳に伝達されるように投与することによって、男性の緊張を伴わない集中力向上・衝動性低下の作用を有することを特徴とする芳香用組成物。 Concentrate improvement without male tension by containing synthesized geraniol or geraniol isolated / purified from natural products as an active ingredient so that it is transmitted to the brain via the olfactory nerve A fragrance composition characterized by having an effect of reducing impulsiveness.
- 前記ゲラニオール、又は、天然物から単離・精製されたゲラニオールは、溶媒に溶かす比率は溶媒に対して１０～２０w/w％の範囲とすることを特徴とする請求項１に記載の芳香用組成物。 2. The fragrance composition according to claim 1, wherein the geraniol or geraniol isolated and purified from a natural product is dissolved in a solvent at a ratio of 10 to 20 w / w% with respect to the solvent. object.
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| JP2015522038A (en) * | 2012-07-06 | 2015-08-03 | オメロス コーポレーション | Andrographis paniculata composition and method for the treatment of addiction |
| JP2017131185A (en) * | 2016-01-29 | 2017-08-03 | 国立研究開発法人産業技術総合研究所 | Food or pharmaceutical composition for preventing or alleviating psychiatric symptom caused by stress |
-
2017
- 2017-04-18 JP JP2017081800A patent/JP2018177723A/en active Pending
- 2017-09-22 WO PCT/JP2017/034207 patent/WO2018193651A1/en active Application Filing
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| JP2006137707A (en) * | 2004-11-12 | 2006-06-01 | Shiseido Co Ltd | Perfume composition for regulating male hormone |
| JP2006219468A (en) * | 2005-02-10 | 2006-08-24 | Satori Osawa | Perfume used on festival for worshipping at shrine or buddhist temple |
| JP2008247894A (en) * | 2007-03-08 | 2008-10-16 | Shiseido Co Ltd | Stress response ameliorating agent |
| JP2008255060A (en) * | 2007-04-05 | 2008-10-23 | Hakugen:Kk | Bath agent and method for bathing by using the same |
| JP2015522038A (en) * | 2012-07-06 | 2015-08-03 | オメロス コーポレーション | Andrographis paniculata composition and method for the treatment of addiction |
| JP2017131185A (en) * | 2016-01-29 | 2017-08-03 | 国立研究開発法人産業技術総合研究所 | Food or pharmaceutical composition for preventing or alleviating psychiatric symptom caused by stress |
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| JP2018177723A (en) | 2018-11-15 |
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