WO2018167451A1 - Dispositif d'électrotransfert et utilisations associées - Google Patents

Dispositif d'électrotransfert et utilisations associées Download PDF

Info

Publication number
WO2018167451A1
WO2018167451A1 PCT/GB2018/000036 GB2018000036W WO2018167451A1 WO 2018167451 A1 WO2018167451 A1 WO 2018167451A1 GB 2018000036 W GB2018000036 W GB 2018000036W WO 2018167451 A1 WO2018167451 A1 WO 2018167451A1
Authority
WO
WIPO (PCT)
Prior art keywords
electrode
electrotransfer device
electrotransfer
pulse
elongate member
Prior art date
Application number
PCT/GB2018/000036
Other languages
English (en)
Inventor
Ida Rachel RAJIAH
Original Assignee
Rajiah Ida Rachel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rajiah Ida Rachel filed Critical Rajiah Ida Rachel
Publication of WO2018167451A1 publication Critical patent/WO2018167451A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00137—Details of operation mode
    • A61B2017/00154—Details of operation mode pulsed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00321—Head or parts thereof
    • A61B2018/00327—Ear, nose or throat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00482—Digestive system
    • A61B2018/005—Rectum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00559—Female reproductive organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613—Irreversible electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00791—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00875—Resistance or impedance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1405—Electrodes having a specific shape
    • A61B2018/1425—Needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1467—Probes or electrodes therefor using more than two electrodes on a single probe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B2018/1475—Electrodes retractable in or deployable from a housing

Definitions

  • an embodiment of the present invention comprises a cable type member 12 having a lumen therethrough (not shown).
  • the cable type member 12 has a proximal end 12a and a distal end 12b.
  • the cable type member 12 is made from medical grade rubber, silicone rubber or polyisoprene and may be electrically insulated and waterproof. The material of cable type member may be further compromised as necessary.
  • the cable type member 12 may be rigid or substantially flexible.
  • the outer diameter of the cable type member 12 may vary from 1.5mm to 50mm and the inner diameter of the lumen may vary from 1.2mm to 49mm depending on its use with or without a surgical or non-surgical tool.
  • a wire passes through the lumen of the cable type member 12 and is connected to a controller comprising a single-pulse or multi-pulse generator (not shown), a multimeter (not shown) and a thermistor (not shown) proximate the proximal end 12a of the cable type member 12.
  • the wire may be a conductor, semiconductor or superconductor and made of graphene, tungsten, copper, silver, gold, chromium or nickel or an alloy of any of these metals or stainless steel, chromel, chromel-alumel, gold-platinum, platinum-palladium, chromel-gold/iron alloy. The material of the wire may be further compromised as necessary.
  • First and second flexible arms 14, 16 are disposed proximate the distal end 12b of the cable type member 12.
  • the first and second flexible arms 14, 16 are generally pincer or tweezer shaped.
  • the first and second flexible arms are generally made of glass, glass-mica, PVC, polyvinyl, Kapton or fluorinated ethylene propylene(FEP).
  • the length of the first and second flexible arms 14, 16 may vary fromlmm to 100mm.
  • the width of the first and second flexible arms may vary from 1mm to 40mm.
  • An end of each of the first and second flexible arms 14, 16 is inserted into the cable type member 12.
  • the other end of each of the first and second flexible arms 14, 16 is unrestrained and mounts respective first and second electrodes 18, 20.
  • the material, length and width of the flexible arms 14, 16 may be further compromised as necessary.
  • the first and second electrodes 18, 20 are pincer or tweezer-shaped.
  • the first and second electrodes 18, 20 may be conductors, semiconductors or superconductors and made of graphene, tungsten, copper, silver, gold, chromium or nickel or an alloy of any of these metals or stainless steel, chromel, chromel-alumel, gold-platinum, platinum-palladium, chromel-gold/iron alloy.
  • the length of the first and second electrode 18, 20 may vary from 1mm to 100mm.
  • the width of the first and second electrodes 18, 20 may vary from 1mm to 40mm.
  • the material, length and width of first and second electrodes 18, 20 may be further compromised as necessary. in another variation, the first and second electrodes 18, 20 may be embedded within the flexible amis 14 and 16 (not shown).
  • the first and second flexible arms 14, 16 are mounted to a common plate (not shown) at the distal end 12b of the cable type member 12 such that the first and second flexible arms 14, 16 may be moved in unison relative to the cable type member 12.
  • a third, needle shaped electrode 22 is disposed between the first and second electrodes 18, 20.
  • the third electrode 22 may be a conductor, semiconductor or superconductor and made of graphene, stainless steel, tungsten, copper, silver, gold, nickel or made of graphene, tungsten, copper, silver, gold, chromium or nickel or an alloy of any of these metals or stainless steel, chromel, chromel-alumel, gold- platinum, platinum-palladium, chromel-gold/iron alloy.
  • the length of third electrode 22 may vary from 1mm to 100mm and the diameter may vary from 0.1 mm to 20mm.
  • the material, length and diameter of the third electrode 22 may be further
  • first electrode 18 and second electrode 20 may also be needle shaped and identical in length and diameter to the third electrode 22 (not shown).
  • the third electrode 22 may be identical to the first and second electrodes18, 20 in both shape and size and may be mounted on a flexible arm or embedded within the flexible arm and disposed at mid-point between the first and second electrodes 18, 20 such that the three electrodes 18, 20 and 22 are oriented in a triangular orientation.
  • the common plate at the distal end 12b of cable type member 12 is operably connected to a lever 24 which penetrates through the cable type member 12 and into the lumen therethrough.
  • the lever 24 is movable between a first position in which the first and second flexible arms 14, 16 are in a retracted configuration relative to the cable type member 12 and a second position in which the first and second flexible arms 14, 16 are in a deployed configuration relative to the cable type member 12.
  • Operation of the lever 24 increases the diameter about the first and second flexible arms 14, 16 as the lever 24 is moved into the second position to deploy the first and second electrodes 18, 20 and decreases the diameter about the first and second flexible arms 14, 16 as the lever 24 is moved into the first position to retract the first and second electrodes 18, 20.
  • first electrode 18, second electrode 20 and third electrode 22 may be electrically movable between a retracted and a deployed position (not shown).
  • the common plate at the distal end 12b of the cable type member 12 may be fixed to the cable type member 12 or may be removable.
  • the first and second electrodes 18, 20 have a first polarity and the third electrode 22 has a second polarity, different to the first.
  • the polarity of the first and second electrodes 18, 20 and third electrode 22 may be reversed so long as the polarity of the first and second electrodes 18, 20 is different to the polarity of the third electrode 22.
  • the polarity of each of the electrode may be changed as necessary.
  • the controller comprises a single-pulse or multi-pulse generator to deliver pulses of alternating current or direct current to the first electrode 18, second electrode 20 and third electrode 22.
  • the pulses may be of variable duration.
  • the pulses may be configured to be high amplitude or low amplitude pulses, square wave or exponential decay pulses.
  • the pulses may comprise of single or multiple pulses. Time interval between pulses may be of variable length.
  • the controller further comprises a multimeter to measure voltage, current, impedance or resistance and temperature of target tissue (not shown). Using the tissue impedance or resistance value a personalised pulse protocol may be designed. Pulses may be delivered manually or programmed onto the single-pulse or multi-pulse generator.
  • the controller further comprises thermistors with audio and visual alarms configured for inrush current limiting, voltage regulation and tissue temperature sensing to ensure patient safety and circuit protection (not shown).
  • the single-pulse or multi-pulse generator is activated using a manually operable switch (not shown) such as a hand switch, foot switch, voice-operated switch or neural control interface.
  • a manually operable switch such as a hand switch, foot switch, voice-operated switch or neural control interface.
  • the individual electrodes 18, 20 and 22 may be activated simultaneously using a single switch or separately using separate switches.
  • the device may comprise an automatic switch or switches for simultaneous or separate activation of the first electrode 18, second electrode 20 and third electrode 22.
  • the switch for activating the first electrode 8, second electrode 20 and third electrode 22 may be located on a remote control unit.
  • the switch may be automatic or manually activated.
  • the manually activated switch may be a foot switch, hand switch, voice-operated switch or neural control interface.
  • the controller may comprise a separate single-pulse or multi- pulse generator to deliver electric pulses of varying amplitude and duration separately to the first electrode 18, second electrode 20 and third electrode 22.
  • the electrotransfer device may be used with or without a surgical or non-surgical tool.
  • the tool may be an endoscope.
  • the insertion tube of the tool, 26 is inserted through an appropriate natural orifice which may be nasal, oral, rectal or vaginal or via a surgical incision.
  • the distal end or bending section of an insertion tube 26 is positioned close to the zone of interest within the target organ or tissue using angulation controls on the tool 26.
  • One or more agents may be injected into one or more sites on the target zone either directly or using syringe and needle accessory inserted through the working channel 28 of the tool 26.
  • the electrotransfer device may be inserted through the working channel 28 of the tool 26.
  • the distal end 12b of the cable type member is deployed to a target zone.
  • distal end 12b of the cable type member is withdrawn from the target zone.
  • the tool 26 is then carefully withdrawn from the person.
  • the target tissue may be cooled or warmed using compressed air delivered through the air channel of the tool.
  • compressed air is delivered to the target zone through the air channel 30 of the tool 26.
  • a compressed air source 32 is connected to an inlet to the air channel 30 by a vortex tube 34.
  • An inlet 36 to the vortex tube 34 is connected to the compressed air source 32 and an outlet 38 from the vortex tube 34 is connected to the inlet to the air channel 30.
  • An outlet from the air channel 30 delivers the compressed air directly to the target zone.
  • Temperature of the compressed air is regulated by a temperature regulator 42 such that the temperature of the compressed air can be increased or decreased as required.
  • the tool 26 has a camera 44 for display of target zone on a visual display unit and a light 46 for illuminating the target zone.
  • one or more agents may be injected into one or more sites on the target zone. Subsequently the distal end 12b of the cable type member of the electrotransfer device according to embodiments of the present invention may be inserted into the target zone. Following pulsing, the distal end 12b of cable type member is withdrawn from the target zone.
  • electrotransfer device may be inserted onto the surface of the body or through an appropriate natural orifice which may be nasal, oral, rectal or vaginal or via a surgical incision.
  • the tissue may be cooled or warmed using compressed air exiting the outlet 38 of vortex tube 34 whilst regulating the temperature of the compressed air using the temperature regulator 42.
  • Figure 1 shows an illustrative view of a first embodiment of the present invention in a deployed configuration.
  • Figure 2 shows the first embodiment of figure 1 in an undeployed configuration.
  • Figure 3 shows an illustrative end view of the first embodiment of figure 1.
  • Figure 4 shows an enlarged partial view of figure 1.
  • Figure 5 shows an illustrative view of a second embodiment of the invention.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Plasma & Fusion (AREA)
  • Otolaryngology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Surgical Instruments (AREA)

Abstract

Un dispositif d'électrotransfert comprend un élément allongé ayant une extrémité distale et une extrémité proximale, une première électrode et une seconde électrode à proximité de l'extrémité distale de l'élément allongé et un moyen de connexion à proximité de l'extrémité proximale de l'élément allongé en vue de connecter de manière fonctionnelle la première électrode et la seconde électrode à un dispositif de commande comprenant un générateur à impulsion unique ou à impulsions multiples, un multimètre et des thermistances, la première électrode et la seconde électrode étant mobiles entre une position rétractée et une position déployée par rapport à l'élément allongé, et le générateur à impulsion unique ou à impulsions multiples fournissant des impulsions électriques à la première électrode et à la seconde électrode lorsqu'elles se trouvent en position déployée.
PCT/GB2018/000036 2017-03-12 2018-03-10 Dispositif d'électrotransfert et utilisations associées WO2018167451A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1703922.3 2017-03-12
GB1703922.3A GB2560511A (en) 2017-03-12 2017-03-12 Electrotransfer device and uses thereof

Publications (1)

Publication Number Publication Date
WO2018167451A1 true WO2018167451A1 (fr) 2018-09-20

Family

ID=58605616

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2018/000036 WO2018167451A1 (fr) 2017-03-12 2018-03-10 Dispositif d'électrotransfert et utilisations associées

Country Status (2)

Country Link
GB (1) GB2560511A (fr)
WO (1) WO2018167451A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11337749B2 (en) 2015-10-07 2022-05-24 Mayo Foundation For Medical Education And Research Electroporation for obesity or diabetes treatment

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004041434A (ja) * 2002-07-11 2004-02-12 Kiyohito Ishida エレクトロポレーション装置
US20060041277A1 (en) * 2002-04-08 2006-02-23 Mark Deem Methods and apparatus for renal neuromodulation
WO2011022674A2 (fr) * 2009-08-20 2011-02-24 Angiodynamics, Inc. Dispositif de fourniture d’énergie à plusieurs électrodes et procédé d’utilisation
US20150216592A1 (en) * 2011-12-15 2015-08-06 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for treating pulmonary hypertension
WO2015148445A1 (fr) * 2014-03-24 2015-10-01 Old Dominion University Research Foundation Réseau d'électrodes de dispositifs cathéter extensibles
US20150328449A1 (en) * 2012-12-21 2015-11-19 University College Cork - National University Of Ireland, Cork A thoracoscopic electroporation device with a suction head and with needle electrodes
US20160331446A1 (en) * 2012-07-04 2016-11-17 Cibiem, Inc. Methods, devices and systems for carotid body ablation via a transradial or transbrachial approach

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007144004A1 (fr) * 2006-06-12 2007-12-21 Region Hovedstaden V/Herlev Hospital Dispositif d'introduction d'électrodes
EP2744563B1 (fr) * 2011-08-16 2016-01-13 Institut National de la Santé et de la Recherche Medicale Dispositif pour le traitement d'une maladie oculaire

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060041277A1 (en) * 2002-04-08 2006-02-23 Mark Deem Methods and apparatus for renal neuromodulation
JP2004041434A (ja) * 2002-07-11 2004-02-12 Kiyohito Ishida エレクトロポレーション装置
WO2011022674A2 (fr) * 2009-08-20 2011-02-24 Angiodynamics, Inc. Dispositif de fourniture d’énergie à plusieurs électrodes et procédé d’utilisation
US20150216592A1 (en) * 2011-12-15 2015-08-06 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for treating pulmonary hypertension
US20160331446A1 (en) * 2012-07-04 2016-11-17 Cibiem, Inc. Methods, devices and systems for carotid body ablation via a transradial or transbrachial approach
US20150328449A1 (en) * 2012-12-21 2015-11-19 University College Cork - National University Of Ireland, Cork A thoracoscopic electroporation device with a suction head and with needle electrodes
WO2015148445A1 (fr) * 2014-03-24 2015-10-01 Old Dominion University Research Foundation Réseau d'électrodes de dispositifs cathéter extensibles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11337749B2 (en) 2015-10-07 2022-05-24 Mayo Foundation For Medical Education And Research Electroporation for obesity or diabetes treatment

Also Published As

Publication number Publication date
GB2560511A (en) 2018-09-19
GB201703922D0 (en) 2017-04-26

Similar Documents

Publication Publication Date Title
EP2928403B1 (fr) Électrode rf à position fixe
EP2825119B1 (fr) Dispositif de remodelage vaginal
EP2575660B1 (fr) Dispositif de suture de tissus à faible énergie
US4691703A (en) Thermal cautery system
KR102628063B1 (ko) 대용적 조직 감소 및 제거 시스템 및 방법
EP1090598B1 (fr) Appareil de coagulation à gaz ionisable à délflexion
US6190386B1 (en) Electrosurgical forceps with needle electrodes
EP1602337B1 (fr) Appareil de coagulation à gaz ionisable à délflexion
WO1995002370A2 (fr) Catheter de tunnellisation
GB2436065A (en) Morcellating device with bipolar cutting electrodes applying pulsed voltage
US7867229B2 (en) High-frequency treatment apparatus
US3982542A (en) Electroresectroscope and method of laparoscopic tubal sterilization
US20150359585A1 (en) Apparatus, systems, and methods for dissection and modification of tissues
EP3552569A1 (fr) Système d'ablation de vaisseau avec terminal d'ablation réglable
WO2018167451A1 (fr) Dispositif d'électrotransfert et utilisations associées
US20230218335A1 (en) High-voltage minimally invasive applicator devices for sub-microsecond pulsing
EP3181077A1 (fr) Protection électrochimique de circuit conducteur dans le corps d'un patient
WO2019160235A1 (fr) Dispositif de traitement de sous-muqueuse
US20090218321A1 (en) Shape Memory Implant Heating Device
JP3791911B2 (ja) レゼクトスコープ装置
JPH0630949A (ja) 電気メス
KR20240031568A (ko) 풍선 압력에 대한 센서를 구비하는 다기능 경막외 카테터
GB1477228A (en) Surgical instruments for coagulation purposes

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18719222

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18719222

Country of ref document: EP

Kind code of ref document: A1