WO2018161627A1 - Appareil de traitement d'hypothermie légère intravasculaire - Google Patents

Appareil de traitement d'hypothermie légère intravasculaire Download PDF

Info

Publication number
WO2018161627A1
WO2018161627A1 PCT/CN2017/109578 CN2017109578W WO2018161627A1 WO 2018161627 A1 WO2018161627 A1 WO 2018161627A1 CN 2017109578 W CN2017109578 W CN 2017109578W WO 2018161627 A1 WO2018161627 A1 WO 2018161627A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube
module
heat exchange
blood
honeycomb
Prior art date
Application number
PCT/CN2017/109578
Other languages
English (en)
Chinese (zh)
Inventor
张晓康
张晓平
Original Assignee
佛山博骏生物科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 佛山博骏生物科技有限公司 filed Critical 佛山博骏生物科技有限公司
Publication of WO2018161627A1 publication Critical patent/WO2018161627A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A61B5/02055—Simultaneously evaluating both cardiovascular condition and temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation

Definitions

  • the invention relates to the technical field of medical instruments, in particular to an intravascular cryotherapy device.
  • the sub-hypothermology technology has experienced more than 70 years of development history, and a large number of studies at home and abroad have confirmed the clinical role of appropriate low temperature and method of brain protection.
  • the international medical community divides low temperature into mild hypo-pothmia 33-35 ° C, moderate low-temperature (modergte hypothermia) 28-32 ° C, and deep hypothermia below 16 ° C.
  • Chinese researchers divided the former two into sub-hypothermia, and this concept was subsequently widely quoted by domestic and foreign counterparts.
  • the sub-hypotherm technology developed and matured in the 1950s and 1960s.
  • hypothermia for severe craniocerebral injury achieved remarkable results. It has been confirmed that the hypothermia at 28-33 ° C has an exact neuroprotective effect. Clinical studies have also found that mild hypothermia treatment does not produce any serious complications, which indicates that sub-hypothermia treatment of patients with severe craniocerebral injury has the advantages of positive efficacy and safety. Regarding the mechanism of action of hypothermia brain protection, the study suggests that there are mechanisms for delaying the depletion of energy metabolism and reducing intracellular acidosis under low temperature conditions.
  • Low temperature inhibits the release of excitotoxic neurotransmitters after ischemia, which further reduces the influx of intracellular calcium ions.
  • Low temperature can inhibit the biosynthesis of oxygen free radicals.
  • the protective effect on BBB is partly related to the inhibition of matrix metalloproteinase activity by low temperature.
  • the mechanism of mild hypothermia brain protection is generally: 1.1) inhibition of metabolic rate low temperature can inhibit the oxygen metabolism rate of brain tissue, preserve high-energy phosphate compounds, inhibit lactic acid accumulation, and maintain the pH value inside and outside the cell. 1.2) inhibit free radical production and promote free radical scavenging.
  • Low temperature inhibits excitatory amino acids (EAA) and catecholamine-mediated oxidative stress.
  • EAA excitatory amino acids
  • catecholamine-mediated oxidative stress Experimental studies have found that hypothermic ischemia significantly inhibits EAA release and reduces catecholamine release by 60% during cerebral ischemia.
  • Low temperature can improve the degree of acidosis in brain tissue, reduce the formation of reactive oxygen species (ROS) and lipid peroxides, and inhibit the formation of jaundice. Via low temperature also reduces the Ca 2 + influx.
  • ROS reactive oxygen species
  • Low temperature inhibits the biosynthesis, release and reuptake of excitatory amino acids (EAA). Low temperature maintains the integrity of the plasma membrane structure, reduces the increase in cytoplasmic Na+ and extracellular K+ concentrations, and reduces the reuptake of glutamate. Studies have found that hypothermia reduces glutamate and glycine concentrations in brain tissue after ischemia. 1.4) Low temperature can alter the activity of various enzymes after ischemia.
  • Low temperature can affect the activity of various enzymes such as phospholipase A2 (PLA2), calmodulin-dependent protein kinase II (CaM PKII), protein kinase C (PKC), and nitric oxide synthase.
  • PKA2 phospholipase A2
  • CaM PKII calmodulin-dependent protein kinase II
  • PKC protein kinase C
  • nitric oxide synthase nitric oxide synthase.
  • PKA2 phospholipase A2
  • CaM PKII calmodulin-dependent protein kinase II
  • PKC protein kinase C
  • nitric oxide synthase nitric oxide synthase.
  • Hypothermia promotes Na + -K + -ATP enzyme, Ca 2 + -ATP enzyme activity recovery, reduce intracellular calcium overload, thereby inhibiting the activation of phospholipase A2.
  • Low temperature also
  • Low temperature can change the transmission of genetic information, and low temperature can promote the expression of immediate early gene (IEG) such as c-fos, c-jun and the like.
  • IEG immediate early gene
  • the study found that the expression levels of c-fosf and Fos-B protein at 1 h after hypothermic ischemia were equivalent to the expression level after 6 h of normal temperature ischemia.
  • the effect of low temperature on different IEC expressions was different. It was found that the level of fos-B mR-NA was significantly increased, the levels of jun-B and jun-C mRNA were moderately elevated, and the levels of c-fos, fra-1 and fra-2 mRNA were observed. There is no significant change.
  • Low temperature can also improve the binding activity of DNA and transcription factors in tissue of cerebral ischemia, inhibit DNA cleavage and promote the recovery of protein synthesis.
  • Low temperature can activate the anti-inflammatory mechanism.
  • hypothermia can increase the survival rate of comatose patients after cardiac arrest and significantly improve neurological prognosis.
  • the mechanism of action of hypothermia involves activation of the cytoprotective pathway. For example, hypothermia induces expression of heat shock protein 70 (HSP70), leading to a shift in the inflammatory cascade during cardiopulmonary bypass, reducing pro-inflammatory mediators and increasing the level of the anti-inflammatory cytokine interleukin-10 (IL-10).
  • HSP70 heat shock protein 70
  • hypothermia can reduce inflammation, increase liver IL-10 levels, and reduce liver cell necrosis.
  • signaling activation is enhanced, transcriptional activation of the enzyme (STAT)-3 pathway is enhanced, and cytokine signaling is enhanced.
  • Inhibitor 3 suppressor of cytokine Signaling, SOCS-3) expression.
  • STAT-3 activation can increase IL-10 levels, and IL-10 and activated STAT-3 can increase the expression of SOCS-3 and decrease the expression of TNF- ⁇ .
  • the present invention proposes an intravascular cryotherapy device.
  • an intravascular cryotherapy device comprising: a saline storage tank, a first conduit, an electronic refrigerator, a second conduit, a central venous catheter, a third conduit; the physiological saline
  • the storage box is connected to the electronic refrigerator through a first conduit; the electronic refrigerator is connected to the central venous conduit through a second conduit; the central venous conduit is connected to the physiological saline storage tank through a third conduit;
  • the electronic refrigerator includes a box body, an electronic refrigerating sheet, and a honeycomb reticulated heat exchange tube, wherein the electronic refrigerating sheet and the honeycomb reticulated heat exchange tube are housed in a box body, and the box body stores propylene glycol
  • the honeycomb mesh heat exchange tube is immersed in the propylene glycol, and the liquid inlet end of the honeycomb mesh heat exchange tube is connected with the first pipeline, and the liquid outlet end of the honeycomb mesh heat exchange tube is connected with
  • the honeycomb network heat exchange tube comprises an outer tube and a honeycomb mesh tube disposed in the outer tube, the outer tube wall of the honeycomb mesh tube is in contact with the inner tube wall of the outer tube, and the honeycomb mesh tube is provided with
  • the through-hole column vertically penetrates the honeycomb mesh tube, and the through-hole columns are vertically parallel arranged, and the horizontal cross-section of the through-hole column is square, circular or regular hexagon.
  • the outer tube of the heat exchange tube has the same length as the honeycomb mesh tube, and the horizontal cross-sectional area of the through-hole column is not less than 2 mm 2 .
  • honeycomb mesh heat exchange tube has a cylindrical spiral shape. Further, the wall thickness between the adjacent through-hole columns is 0.5 mm, and the wall thickness of the outer tube of the heat exchange tube is 1 mm.
  • the number of the electronic refrigeration sheets is six, and the electronic refrigeration sheet specifications are ATL-25W.
  • the central venous catheter is provided with three balloons at the end.
  • the intravascular hypothermia treatment device further includes a computer control system, and the computer control system includes: a monitoring module, a touch screen display, a storage module, a communication module, and an alarm module;
  • the monitoring module can detect ECG, blood pressure, blood oxygen, and pulse in real time, and the detected parameters are displayed on the touch screen display;
  • the storage module stores ECG, blood pressure, blood oxygen, and pulse parameters obtained by the monitoring module;
  • the communication module can transmit ECG, blood pressure, blood oxygen and pulse parameters to the hospital emergency center;
  • the alarm module includes a circulating liquid pressure module, a circulating liquid temperature module, an abnormal bubble detecting module, a blood temperature detecting module, and the circulating fluid pressure
  • the module is used for detecting the pressure of the circulating liquid pipeline, the circulating liquid temperature module is used for detecting the temperature of the circulating liquid, the abnormal bubble detecting module is for detecting whether there is abnormal air bubbles in the circulating liquid, and the blood temperature detecting module includes the blood temperature sensor and the blood temperature detecting The module is used to detect the temperature of the blood.
  • the intravascular hypothermia treatment device further includes a lithium battery, and the lithium battery is used as a backup battery for the case of no power source.
  • the physiological saline storage tank stores physiological saline
  • the physiological saline flows in a physiological saline storage tank, a first pipeline, an electronic refrigerator, a second pipeline, a central venous conduit, and a third pipeline
  • the bolus pump is a circulating power of physiological saline.
  • the electronic refrigerator has an electronic refrigeration chip for propylene glycol refrigeration
  • the physiological saline is cooled to a low temperature physiological saline by heat exchange with propylene glycol through the honeycomb network heat exchange tube, and one end of the central venous catheter enters the human body by the human femoral vein puncture.
  • the vein is then introduced into the central vein of the inferior vena cava.
  • Figure 1 is a schematic view of the structure of the present invention
  • Figure 2 is a cross-sectional view showing a top view of the honeycomb reticulated heat exchange tube of the present invention
  • Figure 3 is a cross-sectional view showing a front view of the honeycomb reticulated heat exchange tube of the present invention
  • Figure 4 is a schematic structural view of a computer control system in the present invention.
  • Fig. 5 is a schematic structural view of an alarm module in the present invention.
  • first”, “second”, and “third” are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, features defining “first”, “second”, and “third” may include one or more of the features, either explicitly or implicitly. In the description of the present invention, the meaning of "a group” is two or more unless otherwise stated.
  • an intravascular cryotherapy device includes: a saline storage tank 1, a first conduit 2, an electronic refrigerator 3, a second conduit 4, a central venous catheter 5, and a third conduit 6;
  • the physiological saline storage tank 1 is connected to the electronic refrigerator 3 through the first conduit 2; the electronic refrigerator 3 is connected to the central venous conduit 5 through the second conduit 4; the central venous catheter 5 and the physiological saline storage tank 1 are passed
  • the third pipe 6 is connected to the second pipe 4; the second pipe 4 is provided with a bolus pump 15; the electronic refrigerator 3 includes a casing 7, an electronic refrigerating sheet 8, and a honeycomb reticulated heat exchange tube 9, and the electronic refrigerating sheet 8
  • the honeycomb reticulated heat exchange tube 9 is housed in the tank 7, the propylene glycol is stored in the tank 7, and the honeycomb reticulated heat exchange tube 9 is immersed in the propylene glycol, and the liquid inlet end of the honeycomb reticulated heat exchange tube 9 is
  • the first pipe 2 is connected, The liquid outlet end of the honeycomb reticulated heat exchange tube 9 is in communication with the second duct 4.
  • the physiological saline storage tank 1 stores physiological saline, and the physiological saline flows through the physiological saline storage tank 1, the first duct 2, the electronic refrigerator 3, the second duct 4, the central venous catheter 5, and the third duct 6, and the bolus is injected.
  • the pump 15 is a circulating power of physiological saline.
  • the electronic refrigerator 3 has an electronic refrigeration sheet 8 for cooling the propylene glycol. When the physiological saline passes through the honeycomb network heat exchange tube 9, it is cooled by heat exchange with propylene glycol to become a low temperature physiological saline, and the central venous catheter.
  • One end of the 5 is inserted into the human femoral vein by the puncture of the human femoral vein, and then introduced into the central vein of the lower cavity.
  • the temperature of the circulating saline in the central venous catheter 5 and the blood in the central venous blood vessel are present, and the surface of the central venous catheter 5 is passed through
  • the blood in the patient's blood vessels undergoes heat exchange to achieve temperature regulation of the sub-hypothermia in the patient's blood vessels.
  • the second conduit 4 is provided with a bolus pump 15.
  • the bolus pump 15 ensures that the physiological saline flowing into the central venous catheter 5 is stabilized within a certain flow rate and flow rate range.
  • the patient's body temperature can be lowered to the sub-hypothermic target temperature within 30 minutes.
  • the honeycomb reticulated heat exchange tube 9 comprises an outer tube 10 and a honeycomb mesh tube 11 disposed in the outer tube 10, an outer tube 10 wall of the honeycomb mesh tube 11 and an inner tube of the outer tube 10
  • the honeycomb mesh tube 11 is provided with a through-hole column 12 vertically penetrating the honeycomb mesh tube 11.
  • the through-hole columns 12 are vertically arranged in parallel, and the horizontal cross-section of the through-hole column 12 is square. Round or regular hexagon.
  • the outer tube 10 of the heat exchange tube has the same length as the honeycomb mesh tube 11, and the horizontal cross-sectional area of the through-hole column 12 is not less than 2 mm 2 .
  • the honeycomb reticulated heat exchange tube 9 has a cylindrical spiral shape.
  • the cylindrical spiral shape is longer relative to the linear path, increasing the time during which the physiological saline exchanges heat with the propylene glycol.
  • the wall thickness between the adjacent through-hole columns 12 is 0.5 mm, and the wall thickness of the outer tube 10 of the heat exchange tube is 1 mm.
  • the number of the electronic refrigerating sheets 8 is six, and the electronic refrigerating sheet 8 is a model number ATL-25W.
  • the electronic cooling sheet can reduce the normal temperature liquid to 1 degree Celsius in 820 minutes.
  • the central venous catheter 5 is provided with three balloons 13 at the end.
  • the balloon 13 is introduced into the central vein of the lower cavity of the human body.
  • the balloon 13 will open, and the balloon 13 will increase and blood in the central venous blood vessel.
  • the balloon 13 of the central venous catheter 5 exchanges heat with the blood, and the liquid does not enter the blood of the blood vessel, thereby avoiding the risk to the heart, the kidney and the like compared with the previous intravenous infusion of the cooling liquid.
  • the way in which the central venous catheter 5 exchanges heat with blood greatly reduces the incidence of chills and muscle twitches in patients.
  • the intravascular hypothermia treatment device further comprises a computer control system, the computer control system comprising: a monitoring module, a touch screen display, a storage module, a communication module, and an alarm module;
  • the monitoring module can detect ECG, blood pressure, blood oxygen, and pulse in real time, and the detected parameters are displayed on the touch screen display;
  • the storage module stores ECG, blood pressure, blood oxygen and pulse parameters obtained by the monitoring module; the communication module can transmit ECG, blood pressure, blood oxygen and pulse parameters to the hospital emergency center; the alarm module includes circulating fluid pressure
  • the module, the circulating liquid temperature module, the abnormal bubble detecting module, the blood temperature detecting module, the circulating liquid pressure module is used for detecting the pressure of the circulating liquid pipeline, the circulating liquid temperature module is used for detecting the temperature of the circulating liquid, and the abnormal bubble detecting module is used.
  • the blood temperature detecting module includes a blood temperature sensor 1414, and the blood temperature detecting module is used to detect the temperature of the blood.
  • the alarm module detects an abnormality, such as when the pressure of the circulating liquid line, the temperature of the circulating liquid exceeds the normal range, or when an abnormal bubble is detected, the alarm module transmits data to the touch screen display, and the touch screen display is an audible and visual alarm.
  • an abnormality such as when the pressure of the circulating liquid line, the temperature of the circulating liquid exceeds the normal range, or when an abnormal bubble is detected
  • the intravascular hypothermia treatment device further comprises a lithium battery, and the lithium battery is used as a backup battery for the case of no power source.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • General Business, Economics & Management (AREA)
  • Business, Economics & Management (AREA)
  • Pulmonology (AREA)
  • Thermal Sciences (AREA)
  • Optics & Photonics (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un appareil de traitement d'hypothermie légère intravasculaire qui comprend : un réservoir de stockage de solution saline normale (1), un premier tube (2), un réfrigérateur électronique (3), un second tube (4), un cathéter veineux central (5), et un troisième tube (6). Le réservoir de stockage de solution saline normale (1) communique avec le réfrigérateur électronique (3) au moyen du premier tube (2). Le réfrigérateur électronique (3) communique avec le cathéter veineux central (5) au moyen du second tube (4). Le cathéter veineux central (5) communique avec le réservoir de stockage de solution saline normale (1) au moyen du troisième tube (6). Le second tube (4) est pourvu d'une pompe à perfusion (15). Une entrée de liquide d'un tube d'échange de chaleur à maille cellulaire (9) dans le réfrigérateur électronique (3) communique avec le premier tube (2), et une sortie de liquide du tube d'échange de chaleur à maille cellulaire (9) communique avec le second tube (4). Une solution saline normale dans le réservoir de stockage de solution saline normale (1) est délivrée au tube d'échange de chaleur à maille cellulaire (9) par la pompe à perfusion (15), et refroidie à une solution saline normale à basse température par une ailette de refroidissement électronique (8). Une extrémité du cathéter veineux central (5) pénètre dans la veine cave inférieure par l'intermédiaire d'une perforation de veine fémorale humaine. La solution saline normale circulante a une température différente de celle du sang dans la veine cave, et une surface du cathéter veineux central (5) échange de la chaleur avec le sang dans le vaisseau d'un patient.
PCT/CN2017/109578 2017-03-08 2017-11-06 Appareil de traitement d'hypothermie légère intravasculaire WO2018161627A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710134849.1 2017-03-08
CN201710134849.1A CN106859843A (zh) 2017-03-08 2017-03-08 一种血管内亚低温治疗装置

Publications (1)

Publication Number Publication Date
WO2018161627A1 true WO2018161627A1 (fr) 2018-09-13

Family

ID=59170696

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2017/109578 WO2018161627A1 (fr) 2017-03-08 2017-11-06 Appareil de traitement d'hypothermie légère intravasculaire

Country Status (2)

Country Link
CN (1) CN106859843A (fr)
WO (1) WO2018161627A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106859843A (zh) * 2017-03-08 2017-06-20 佛山博骏生物科技有限公司 一种血管内亚低温治疗装置
CN108814803B (zh) * 2018-06-14 2021-05-04 中国医学科学院生物医学工程研究所 一种体温调控方法、装置、设备和存储介质
CN108743001A (zh) * 2018-06-27 2018-11-06 张雷 一种重症医学科用血管内亚低温治疗仪
CN109674575A (zh) * 2018-12-23 2019-04-26 庄育田 一种重症医学科用血管内亚低温治疗仪
CN109966050A (zh) * 2019-04-25 2019-07-05 温建娟 一种颅脑灌注降温便携箱
CN112924053B (zh) * 2021-01-26 2023-01-10 北京航空航天大学 一种模拟血液温场及温度监测的实验装置
CN113397806B (zh) * 2021-05-25 2022-08-30 南昌大学第二附属医院 一种亚低温治疗用血管内热交换温度调节控制装置
CN115137549B (zh) * 2022-01-29 2023-04-18 瓴科医疗科技(杭州)有限公司 一种亚低温治疗用双层热交换球囊

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN201414869Y (zh) * 2009-06-24 2010-03-03 中国科学院自动化研究所 一种血管内温度自动调节仪
WO2012012740A1 (fr) * 2010-07-23 2012-01-26 Neurosave, Inc. Imagerie de fonction cérébrale régionale et globale, perfusion, œdème et lésion au moyen d'une imagerie thermique, durant la modulation thermique des voies aérodigestives supérieures
CN203107397U (zh) * 2013-03-15 2013-08-07 成都嘉逸科技有限公司 一种血管内温度自动调节装置
CN204618553U (zh) * 2014-12-08 2015-09-09 刘思伯 血管外冷却-亚低温治疗控制系统
CN105287095A (zh) * 2015-11-23 2016-02-03 邹秀丽 一种重症医学科用血管内亚低温治疗仪
CN106859843A (zh) * 2017-03-08 2017-06-20 佛山博骏生物科技有限公司 一种血管内亚低温治疗装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012104381A1 (de) * 2012-05-22 2013-11-28 Acandis Gmbh & Co. Kg Medizinisches System zum endovaskulären Temperieren von Blut und medizinischer Katheter
CN202692796U (zh) * 2012-07-17 2013-01-23 山东宝纳新材料有限公司 一种蜂窝式换热管
CN104042396A (zh) * 2013-03-15 2014-09-17 成都嘉逸科技有限公司 血管内温度自动调节装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN201414869Y (zh) * 2009-06-24 2010-03-03 中国科学院自动化研究所 一种血管内温度自动调节仪
WO2012012740A1 (fr) * 2010-07-23 2012-01-26 Neurosave, Inc. Imagerie de fonction cérébrale régionale et globale, perfusion, œdème et lésion au moyen d'une imagerie thermique, durant la modulation thermique des voies aérodigestives supérieures
CN203107397U (zh) * 2013-03-15 2013-08-07 成都嘉逸科技有限公司 一种血管内温度自动调节装置
CN204618553U (zh) * 2014-12-08 2015-09-09 刘思伯 血管外冷却-亚低温治疗控制系统
CN105287095A (zh) * 2015-11-23 2016-02-03 邹秀丽 一种重症医学科用血管内亚低温治疗仪
CN106859843A (zh) * 2017-03-08 2017-06-20 佛山博骏生物科技有限公司 一种血管内亚低温治疗装置

Also Published As

Publication number Publication date
CN106859843A (zh) 2017-06-20

Similar Documents

Publication Publication Date Title
WO2018161627A1 (fr) Appareil de traitement d'hypothermie légère intravasculaire
EP3650057A1 (fr) Systèmes et procédés de traitement du sang
CN103417325B (zh) 亚低温治疗-血管内热交换温度调节控制装置
WO2003105736A1 (fr) Catheter pour le refroidissement topique et dispositif de refroidissement topique utilisant un tel catheter
US9283112B2 (en) Patient temperature control catheter with outer sleeve cooled by inner sleeve
CN105287095A (zh) 一种重症医学科用血管内亚低温治疗仪
Kollmar et al. Hypothermia in focal ischemia: implications of experiments and experience
Shields et al. Rapid cooling and surgery at temperatures below 20° C
US20120226337A1 (en) Method and System for Treatment of a Body of a Mammal in Cardiac Arrest
Shuja et al. Profound hypothermia decreases cardiac apoptosis through Akt survival pathway
Patel et al. Comparison of fluid warmer performance during simulated clinical conditions
CN207532478U (zh) 一种血管内亚低温治疗装置
CN203408155U (zh) 亚低温治疗-血管内热交换温度调节控制装置
US9993365B2 (en) Surgical heating and cooling system and devices and methods for the use thereof
CN102512734B (zh) 一种便携式冰盐水自动亚低温仪
CN112656580B (zh) 一种血管冷热试制仪及使用方法
US20160184505A1 (en) Patient warming system
CN112741724A (zh) 一种便携式鼻腔内亚低温治疗装置
Mongardon et al. Targeted temperature management with total liquid ventilation after ischemic spinal cord injury
CN112924053A (zh) 一种模拟血液温场及温度监测的实验装置
CN214805938U (zh) 一种便携式鼻腔内亚低温治疗装置
Shrikhande Therapeutic Hypothermia
Varon Therapeutic hypothermia: implications for acute care practitioners
Zimmermann Hypothermia, hyperthermia, and rhabdomyolysis
Arrowsmith et al. Deep hypothermic circulatory arrest

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17900024

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 17900024

Country of ref document: EP

Kind code of ref document: A1