WO2018152368A1 - Pyrrolo [1,2-b] pyridazine derivatives - Google Patents

Pyrrolo [1,2-b] pyridazine derivatives Download PDF

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Publication number
WO2018152368A1
WO2018152368A1 PCT/US2018/018431 US2018018431W WO2018152368A1 WO 2018152368 A1 WO2018152368 A1 WO 2018152368A1 US 2018018431 W US2018018431 W US 2018018431W WO 2018152368 A1 WO2018152368 A1 WO 2018152368A1
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Prior art keywords
alkyl
cycloalkyl
heterocyclyl
aryl
heteroaryl
Prior art date
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PCT/US2018/018431
Other languages
French (fr)
Inventor
Elizabeth M. Bacon
Gediminas BRIZGYS
Elbert Chin
Chienhung CHOU
Jeromy J. Cottell
John O. Link
James G. TAYLOR
Winston C. Tse
Nathan E. Wright
Zheng-Yu Yang
Jennifer R. Zhang
Sheila M. Zipfel
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Gilead Sciences, Inc.
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Publication date
Priority to KR1020197026476A priority Critical patent/KR102337055B1/en
Priority to FIEP18708796.0T priority patent/FI3583105T3/en
Priority to LTEPPCT/US2018/018431T priority patent/LT3583105T/en
Priority to SG11201906763RA priority patent/SG11201906763RA/en
Priority to IL267979A priority patent/IL267979B/en
Priority to CR20190373A priority patent/CR20190373A/en
Priority to DK18708796.0T priority patent/DK3583105T3/en
Priority to EP18708796.0A priority patent/EP3583105B1/en
Priority to CA3050148A priority patent/CA3050148A1/en
Priority to EA201991544A priority patent/EA201991544A1/en
Priority to UAA201908592A priority patent/UA124548C2/en
Priority to AU2018221812A priority patent/AU2018221812B2/en
Priority to MX2019009840A priority patent/MX2019009840A/en
Priority to MA47500A priority patent/MA47500B1/en
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Priority to CN201880012452.8A priority patent/CN110300754A/en
Priority to PE2019001681A priority patent/PE20191540A1/en
Priority to JP2019543909A priority patent/JP6924267B2/en
Publication of WO2018152368A1 publication Critical patent/WO2018152368A1/en
Priority to PH12019550128A priority patent/PH12019550128A1/en
Priority to CONC2019/0008868A priority patent/CO2019008868A2/en
Priority to SA519402462A priority patent/SA519402462B1/en
Priority to ZA2019/05456A priority patent/ZA201905456B/en
Priority to AU2022228165A priority patent/AU2022228165A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the present disclosure relates to novel compounds that are inhibitors of the kinase IRAK4.
  • the disclosure also relates to methods for preparing the compounds and to pharmaceutical compositions comprising such compounds.
  • Interleukin-1 receptor-associated kinase-4 is a serine-threonine kinase which acts as a mediator in interleukin- 1/Toll-like receptor (IL-l/TLR) signaling cascades. More particularly, IRAK4 is involved in activation of adaptor protein myeloid differentiation primary response gene 88 (MyD88) signaling cascades and is
  • IL-1R/TLR results in the activation of MyD88 which recruits IRAK4 and IRAKI to form a signaling complex.
  • This complex then interacts with a series of kinases, adaptor proteins, and ligases, ultimately resulting in the activation of nuclear factor kappa- light-chain-enhancer of activated B cells (NF- ⁇ ) and activator protein- 1, inducing the generation of
  • inhibitors of IRAK4 may be useful in the treatment of inflammatory disorders, including autoimmune disorders, such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), gout, Lyme arthritis, systemic lupus erythematosus (SLE), Sjogren's syndrome and viral myocarditis.
  • autoimmune disorders such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), gout, Lyme arthritis, systemic lupus erythematosus (SLE), Sjogren's syndrome and viral myocarditis.
  • RA rheumatoid arthritis
  • IBD inflammatory bowel disease
  • SLE systemic lupus erythematosus
  • Sjogren's syndrome and viral myocarditis.
  • certain cancers including lymphomas, may contain one or more mutations in the MYD88 adaptor protein, leading to a constitutively active signaling cascade that may promote survival of tumor cells.
  • IRAK4 inhibitors for autoimmunity and lymphoma J. Exp. Med. 2015 Vol. 212 No. 13 2189-2201
  • an inhibitor of IRAK4 may be useful in the treatment of cancers, including lymphomas.
  • IRAK4 inhibiting pharmaceuticals There are currently no approved IRAK4 inhibiting pharmaceuticals. Therefore, it would be useful to provide an IRAK4 inhibiting compound with properties suitable for administration as a pharmaceutical agent to a mammal, particularly a human.
  • WO2016210034, WO2016210036, WO2015150995, WO2016127024, and WO2016210037 recite compounds said to be useful as IRAK4 inhibitors.
  • compositions useful as inhibitors of IRAK4.
  • Some compounds of the disclosure may find use in pharmaceutical compositions, together with at least one pharmaceutically acceptable excipient, for treating a subject in need thereof.
  • Compounds of the present disclosure also have been found to inhibit production of TNFa, IL-6, IL- ⁇ and IL-23, all of which are mediators of inflammation.
  • the disclosure also provides compositions, including pharmaceutical compositions, kits that include the compounds, and methods of using and making the compounds.
  • R 1 and R 2 are each independently selected from:
  • Ci-io alkyl optionally substituted with Z 1 ;
  • R 3 and R 4 are each independently selected from:
  • Ci-9 alkyl optionally substituted with Z 1 ;
  • R 5 , R 6 and R 7 are each independently selected from:
  • Ci-5 alkyl optionally substituted with Z 1 ;
  • Z 1 is independently oxo, halo, -NO2, -N 3 , -CN, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3 -15 cycloalkyl, Ci_ 8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 12 , -C(0)-R 12 , -C(0)0- R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0- R 12 , -N(R 12 )C(0)N(R 12 )( R 12 ), -N(R 12 )S(0) 2 (R 12 ),
  • any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Z la ;
  • each Z la is independently oxo, halo, -NO2, -CN, -N 3 , C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3 -15 cycloalkyl, Ci_ 8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 12 , -C(0)R 12 , -C(0)0- R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )-C(0)R 12 , - N(R 12 )C(0)0(R 12 ), -N(R 12 )C(0)N(R 12 )( R 12 ), -N(R 12 )S(0) 2 (R 12 ), -N(R 12 )S(0) 2 (R 12 ), -N(R 12 )S(0) 2 - N
  • any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Z lb ;
  • each R 12 is independently H, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3 _i5 cycloalkyl, aryl, heteroaryl or heterocyclyl;
  • any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Z la ;
  • each Z lb is independently oxo, hydroxy, halo, -NO2, -N3, -CN, C1-9 alkyl, C2-6 alkenyl, C2- 6 alkynyl, C 3 -15 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -0(Ci_9 alkyl), -0(C 2 - 6 alkenyl), -0(C 2 - 6 alkynyl), -0(C 3 -i5 cycloalkyl), -0(Ci_ 8 haloalkyl), - O(aryl), -O(heteroaryl), -O(heterocyclyl), -NH 2 , -NH(Ci_ 9 alkyl), -NH(C 2 - 6
  • cycloalkyl -C(0)NH(Ci_ 8 haloalkyl), -C(0)NH(aryl), -C(0)NH(heteroaryl), - C(0)NH(heterocyclyl), -C(0)N(C 1-9 alkyl) 2 , -C(0)N(C 3-15 cycloalkyl) 2 , -C(0)N(C 2 _ 6 alkenyl) 2 , -C(0)N(C 2 _ 6 alkynyl) 2 , -C(0)N(C 3 _ 15 cycloalkyl),, -C(0)N(d_ 8 haloalkyl) 2 , - C(0)N(aryl) 2 , -C(0)N(heteroaryl) 2 , -C(0)N(heterocyclyl) 2 , -NHC(0)(Ci_ 9
  • any alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with one or more halo, Ci -9 alkyl, Ci_ 8 haloalkyl, -OH, -NH 2 , -NH(Ci -9 alkyl), -NH(C 3 _i 5 cycloalkyl), -NH(Ci_ 8 haloalkyl), -NH(aryl), -NH(heteroaryl), -NH(heterocyclyl), -N(C 1-9 alkyl) 2 , -N(C 3 _i 5 cycloalkyl) 2 , -NHC(0)(C 3 _i 5 cycloalkyl), -NHC(0)(Ci_ 8 haloalkyl), - NHC(0)(aryl), -NHC(0)(heteroaryl), -NHC(0)(heterocyclyl), -NHC(0)0(Ci_ 9 al
  • cycloalkyl -0(Ci_8 haloalkyl), -O(aryl), -0(he ternary 1), -O(heterocyclyl), or -0(Ci_ 9 alkyl);
  • R 1 is C 3 alkyl
  • R 2 is C5 alkyl substituted with F and hydroxyl
  • R 3 , R 5 , R 6 , R 7 are H
  • R 4 is CN, then R 1 is substituted with Z 1 ;
  • R 1 is Ci_io alkyl optionally substituted with Z 1 , with the proviso that when R 1 is C 3 alkyl, R 2 is C5 alkyl substituted with F and hydroxyl, R 3 , R 5 , R 6 , R 7 are H, and R 4 is CN, then R 1 is substituted with Z l .
  • R 1 or R 2 is Ci_io alkyl, C3-10 cycloalkyl, 5-10 membered heteroaryl, C 6 -io aryl, 4-7 membered monocyclic heterocyclyl, or 6-12 membered bicyclic heterocyclyl, two Z 1 groups either attached to the same atom on the R 1 or the R 2 group, or two Z 1 groups attached to adjacent atoms on the R 1 or the R 2 group, append together to form a 3-6 membered cycloalkyl or 3-6 membered heterocyclyl.
  • R 1 is methyl
  • R 1 is C 6 -io alkyl optionally substituted with
  • R 1 is Ci_5 alkyl substituted with one or more substituents selected from -CI, oxo, -CN, C2-6 alkenyl, C2-6 alkynyl, cyclopropyl, naphthyl, heteroaryl, nitrogen or sulfur containing monocyclic heterocyclyl, bicyclic heterocyclyl, C 7-15 cycloalkyl, -O-R 9 , -C(0)-R 12 , -C(0)0-R 12 , -C(0)-N(R 12 )( R 12 ), - N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R 12 , -N(R 12 )C(0)N(R 12 )( R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)-
  • R 9 at each occurrence is independently C1-9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, Ci_6 haloalkyl, C3-15 cycloalkyl, aryl, heterocyclyl, or heteroaryl;
  • each C1-9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, Ci_6 haloalkyl, C3-15 cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with Z la ;
  • Ci -5 alkyl is also optionally substituted with Z 1 ;
  • each said C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, cyclopropyl, naphthyl, heteroaryl, nitrogen or sulfur containing monocyclic heterocyclyl, bicyclic heterocyclyl, or C 7- i 5 cycloalkyl is optionally substituted with Z la .
  • R 1 is Ci_5 alkyl optionally substituted with z 1 ;
  • Ci -5 alkyl is substituted with one or more C 4 _6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or phenyl;
  • C 4 _ 6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or phenyl is substituted by one or more halo, oxo, -CN, C2-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3 -7 cycloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 9 , -C(0)-R 12 , -C(0)0-R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R 12 , - N(R 12 )C(0)N(R 12 )( R 12 ), -N(R 12 )S(0) 2 (R 12 ),
  • R 1 is Ci -5 alkyl optionally substituted with F or -OH and substituted with one or more substituents selected from C 4 _ 6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or phenyl; wherein said C 4 _ 6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or phenyl is substituted with two or more substituents selected from -OH and -CH 3 and optionally substituted with Z la .
  • R 1 is C3-10 cycloalkyl optionally substituted with Z
  • R 1 is C3-10 cycloalkyl optionally substituted with Z
  • R 1 is C7-1 0 cycloalkyl optionally substituted with Z 1 , wherein when said C7-C1 0 cycloalkyl is bicyclo[2.2.1]heptanyl, then said C7-1 0 cycloalkyl is substituted with at least one of oxo, -CI, -NO2, -CN, -N3, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 7- i 5 cycloalkyl, C5-8 haloalkyl, aryl, pyrazolyl, -O-R 9 , -C(0)0- R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )-C(0)
  • R is In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomer, or deuterated analog thereof, R 1 is a 3-10 membered bridged bicyclic group optionally substituted with one or more Z 1 group.
  • R 1 is a 3-10 membered bridged bicyclic group optionally substituted with one or more Z 1 group.
  • R 1 is a 3-10 membered bridged hetero bicyclic group optionally substituted with 1 group.
  • R 1 is C 3 -6 cycloalkyl substituted with one or more -O-R 16 ; wherein said C 3 -6 cycloalkyl is optionally substituted with Z 1 ;
  • R 16 at each occurrence is independently C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci_6 haloalkyl, C 3 -15 cycloalkyl, aryl, heterocyclyl, or heteroaryl; wherein each C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci_6 haloalkyl, C 3 -15 cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with Z la
  • R 1 is C 3 -6 cycloalkyl substituted with one or more -C(0)-R n ; wherein said C 3 -6 cycloalkyl is optionally substituted with Z 1 ;
  • R 11 at each occurrence is independently Ci_g alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3 _ ⁇ cycloalkyl, aryl, heterocyclyl, or heteroaryl,
  • each C1-9 alkyl is optionally substituted with -NO2, -N3, -CN, C2-6 alkenyl, C2-6 alkynyl, C 3 -15 cycloalkyl, C 4 _8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 12 , -C(O)- R 12 , -C(0)0-R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0
  • R 12 -N(R 12 )C(0)0-R 12 , -N(R 12 )C(0)N(R 12 )( R 12 ), -N(R 12 )S(0) 2 (R 12 ), - NR 12 S(0) 2 N(R 12 )( R 12 ), -NR 12 S(0) 2 0(R 12 ), -OC(0)R 12 , -OC(0)-N(R 12 )( R 12 ), -Si(R 12 ) 3 , -S-R 12 , -S(0)R 12 , -S(0)(NH)R 12 , -S(0) 2 R 12 or -S(0) 2 N(R 12 )( R 12 ); and wherein each said C2-6 alkenyl, C2-6 alkynyl, C 3 -15 cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with Z la ;
  • R 1 is C 3 -6 cycloalkyl substituted with one or more oxo, C5-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3 -15 cycloalkyl, aryl, heteroaryl, heterocyclyl, -C(0)0-R 12 , -C(0)-N(R 9 )(R 9 ), -C(0)N(H)(C 4 _ 9 alkyl), -C(O)N(H)(C 3-10 cycloalkyl), -C(0)N(H)( heterocyclyl), -C(0)N(H)(aryl), -C(0)N(H)(heteroaryl) - N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)-R 12 , -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)-R 12 ,
  • R 1 is
  • R 1 is C 3 -6 cycloalkyl substituted with C 4 alkyl, wherein said C 4 alkyl is optionally substituted with halo, -NO2, -CN, -N 3 , C2-6 alkenyl, C2-6 alkynyl, C 3 -15 cycloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 9 , -C(0)-R 12 , - C(0)0-R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)- R 12 , -N(R 12 )C(0)0-R 12 , -N(R 12 )C(0)N(R 12 )( R 12 ), -N(R 12 )N( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R
  • C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3 -15 cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Z la ;
  • R 1 is C 3 -6 cycloalkyl optionally substituted with Z 1 ; and wherein said C 3 -6 cycloalkyl is substituted with four or more substituents selected from the group consisting of F, -OH, -CI, -CN, C1-3 alkyl, C1-3 fluoroalkyl, Ci_ 4 hydroxyalkyl, Ci_ 4 alkoxy, -C(0)NH 2 , -C(0)NH(Ci_ 3 alkyl); and -C(0)(Ci_ 3 fluoroalkyl).
  • R 1 is C 3 -6 cycloalkyl substituted with C1-3 fluoroalkyl, or -C(0)(Ci_3 fluoroalkyl) wherein said C 3 -6 cycloalkyl is also optionally substituted with Z 1 ; wherein said Ci -3 fluoroalkyl or -C(0)(Ci_3 fluoroalkyl) is further substituted with at least one oxo, -CI, -N0 2 , -CN, -N3, C 3 -9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3 -15 cycloalkyl, C 3 -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R 12 , -C(0)R 12 , -C(0)0-R 12 , -C(0)N(R 12
  • R 1 is C 3 -6 cycloalkyl substituted with at least one Ci-3 alkyl or C1-4 hydroxyalkyl wherein said C 3 -6 cycloalkyl is optionally substituted with Z 1 ;
  • C1-3 alkyl or C1-4 hydroxyalkyl is further substituted with oxo, chloro, -NO2, -CN, -N 3 , C4-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3 -15 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 9 , -C(0)R 12 , -C(0)0-R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )-C(0)R 12 , -N(R 12 )C(0)0(R 12 ), -N(R 12 )C(0)N(R 12 )( R 12 ), - N(R 12 )S(0) 2 (R 12 ), -N(R 12 )S(0) 2 (R 12 ), -
  • R 1 is C 3 _ 6 cycloalkyl substituted with at least one C1-4 alkoxy or C(0)NH(Ci_3 alkyl); wherein said C 3 -6 cycloalkyl is optionally substituted with Z 1 and wherein said C1-4 alkoxy or C(0)NH(Ci_3 alkyl) is further substituted with oxo, halo, -NO2, -CN, -N 3 , C4_g alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3- is cycloalkyl, Ci_ 8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 12 , -C(0)R 12 , -C(0)0- R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(
  • R 1 is 5-10 membered heteroaryl optionally substituted with Z 1 .
  • R 1 is 5-10 membered heteroaryl optionally substituted with Z 1 , wherein when said 5-10 membered heteroaryl is furanyl, pyranyl, pyrraolyl, imidazolyl, pyrazolyl, triazoyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, thiaphenyl, oxazoyl, thiazoyl, said 5-10 membered heteroaryl is optionally substituted with a 5-12 membered bicyclic ring or a 5-12 membered hetero bicyclic ring, wherein the bicyclic ring and the hetero bicyclic
  • R 1 is imidazolyl, triazolyl, oxazolyl, isoxazolyl, pyridinyl, thiadiazole, oxadiazole, pyrimidinyl, pyridizinyl, pyrazinyl, isothiazolyl, tetrazolyl, thiophenyl, furanyl, triazinyl, or 8-10 membered heteroaryl optionally substituted with Z 1 .
  • R 1 is
  • R 1 is a 6 membered heteroaryl optionally substituted with Z 1 .
  • R 1 is pyridine.
  • R 1 is a 4-7 membered monocyclic heterocyclyl optionally substituted with Z 1 .
  • R 1 is a 4-7 membered monocyclic heterocyclyl optionally substituted with Z 1 .
  • R 1 is azetidinyl, morpholinyl
  • thiomorpholinyl 4-7 membered sultam, 4-7 membered cyclic carbamate, 4-7 membered cyclic carbonate, or 4-7 membered cyclic sulfide optionally substituted with Z 1 .
  • R 1 is 6-12 membered bicyclic heterocyclyl optionally substituted with Z 1 ; wherein when said 6-12 membered bicyclic heterocyclyl is 4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazinyl then said 6-12 membered bicyclic heterocyclyl is substituted with at least one oxo, C 3 -6 cycloalkyl, or C(0)(Ci_5 alkyl).
  • R 1 is 6-12 membered bicyclic optionally substituted with Z 1 ; wherein when said 6-12 membered bicyclic is bicyclo[2.2.2] octane, then said 6-12 membered bicyclic is substituted with Ci_3 alkyl, C2-6 alkenyl, C2-6 alkynl, 3-6 membered cyclo alkyl, 3-6 membered heterocyclyl, 5-6 membered aryl, 5-6 membered heteroaryl, where the C1-3 alkyl, C2-6 alkenyl, C2-6 alkynl, 3-6 membered cyclo alkyl, 3-6 membered heterocyclyl, 5-6 membered aryl, 5-6 membered heteroaryl groups can further be substituted with one or more Z la group(s).
  • R 1 is 6-12 membered bicyclic heterocyclyl optionally substituted with Z 1 ; wherein when said 6-12 membered bicyclic heterocyclyl is 2-oxabicyclo[2.2.2]octane, then said 6-12 membered bicyclic heterocyclyl is substituted with C1-3 alkyl, C2-6 alkenyl, C2-6 alkynl, 3-6 membered cyclo alkyl, 3-6 membered heterocyclyl, 5-6 membered aryl, 5-6 membered heteroaryl, where the Ci -3 alkyl, C2-6 alkenyl, C2-6 alkynl, 3-6 membered cyclo alkyl, 3-6 membered heterocyclyl, 5-6 membered aryl, 5-6 membered heteroaryl groups can further be substituted with one or more Z la group(s).
  • R 1 is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl; wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl or thiazolyl, is substituted with one or more substituents selected from -CI, oxo, -CN, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C7-10 cycloalkyl, aryl, pyridinyl, pyridizinyl, 5-10 membered bicyclic heteroaryl, 5-membered heteroaryl, nitrogen or sulfur containing monocyclic heterocycl
  • R 1 is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl;
  • oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl is optionally substituted with Z 1 ;
  • oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, thiazolyl is substituted with 3 or more substituents selected from F, -OH, C1-4 alkyl, Ci_ 3 hydroxyalkyl, Ci_ 4 fluoroalkyl, -(CH ⁇ OCC ⁇ alkyl), -C(0)(Ci_ 3 fluoroalkyl), -S(0) 2 (Ci_3 alkyl), C 3 -6 cycloalkyl, C 3 -6 fluorocycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrimidinyl, fluoropyrimidinyl, or methoxyprimidinyl.
  • R 1 is pyrrolidinyl, piperidinyl, pyrazolyl or thiazolyl; wherein said pyrrolidinyl, piperidinyl, pyrazolyl or thiazolyl is optionally substituted with Z 1 ; wherein said pyrrolidinyl, piperidinyl, pyrazolyl or thiazolyl is substituted with one or more substituents independently selected from -(CH 2 )i_ 3 0(Ci_3 alkyl), -S(0) 2 (Ci_3 alkyl), oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or CH 2 (C 3 - 6 cycloalkyl); and wherein said -(CH 2 )i_ 3 0(Ci_3 alkyl), -S(0) 2 (Ci_3 alkyl);
  • R 1 is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl; wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl is optionally substituted with a -F or -OH and is substituted with one or more substituents independently selected from C1-4 alkyl or C1-3 hydroxyalkyl;
  • Ci_ 4 alkyl or Ci -3 hydroxyalkyl is substituted with one or more oxo, -CI, - NO2, -CN, -N 3 , C4-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 7- i 5 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 16 , -C(0)R 12 , -C(0)0- R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )-C(0)R 12 , - N(R 12 )C(0)0(R 12 ), -N(R 12 )C(0)N(R 12 )( R 12 ), -N(R 12 )S(0) 2 (R 12 ), -N(R 12 )S(0) 2
  • any alkyl, hydroxyalkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Z lb .
  • R 1 is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl; wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl is optionally substituted with a -F or -OH and is substituted with one or more substituents independently selected from Ci_ 4 fluoroalkyl, - C(0)(Ci_3 fluoroalkyl), C 3 -6 cycloalkyl, C 3 -6 fluorocycloalkyl, and fluoropyrimidinyl; wherein said Ci_ 4 fluoroalkyl, -C(0)(Ci_3 fluoroalkyl), C 3 -6 cycloalkyl, C 3 -6 cycloalkyl
  • fluorocycloalkyl or fluoropyrimidyl is substituted with one or more oxo, -CI, -NO2, -CN, -N3, C4-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 12 , -C(0)R 12 , -C(0)0- R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )-C(0)R 12 , - N(R 12 )C(0)0(R 12 ), -N(R 12 )C(0)N(R 12 )( R 12 ), -N(R 12 )S(0) 2 (R 12 ), -N(R 12 )S(0) 2 (R 12
  • R 1 is C 6 -io aryl optionally substituted with Z 1 .
  • R 1 is C 6 -io aryl is substituted with one or more Ci_6 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 9 , -C(0)R n , -C(0)0-R 12 , -C(0)NH(C 3 -6 cycloalkyl), -C(0)NH(C 4 - 6 alkyl), - C(0)heterocyclyl, N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R 12 , - N(R 1Z )C(0)N(R 1Z )( R 1Z ), -N
  • Ci_6 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3 5 cycloalkyl, aryl, heteroaryl, heterocyclyl, -C(0)NH(C 3 - 6 cycloalkyl), -C(0)NH(C 4 - 6 alkyl),or -C(0)heterocyclyl is optionally substituted with Z la ;
  • R 1 is C 6 -io aryl substituted with one or more -C(0)NH(Ci_3 alkyl) and optionally substituted with Z la ;
  • -C(0)NH(Ci_3 alkyl) is substituted with one or more oxo, halo, -N0 2 , -CN, -N 3 , C 3 -9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3 -15 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 12 , -C(0)R 12 , -C(0)0-R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )-C(0)R 12 , -N(R 12 )C(0)0(R 12 ), -N(R 12 )C(0)N(R 12 )( R 12 ), - N(R 12 )S(0) 2 (R 12 ), -N(N(
  • C 3 -9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3 5 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Z lb .
  • R 1 is C 6 -io aryl substituted with one or more -C(0)(Ci_3 fluoroalkyl); wherein said -C(0)(Ci_3 fluoroalkyl) is substituted with one or more oxo, -CI, -N0 2 , -CN, -N 3 , C 3 -9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3 -15 cycloalkyl, C 3- 8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 12 , -C(0)R 12 , -C(0)0-R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R
  • C 3 -9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3 5 cycloalkyl, C 3 -8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Z lb ;
  • R 1 is -N(R 12 )( R 12 ), - S(0) 2 R 12 , -S(0) 2 N(R 12 )( R 12 ), or -H.
  • R is * .
  • R 2 is Ci_io alkyl optionally substituted with
  • R 2 is Ci_io alkyl
  • R 2 is methyl
  • R 2 is C 7- io alkyl, optionally substituted with Z 1 .
  • R 2 is Ci_6 alkyl substituted with one or more -0(Ci_2 alkyl), -NHC(0)(Ci_ 3 alkyl), or -S(0) 2 (C 1-3 alkyl); wherein said -0(C 1-2 alkyl) is substituted with one or more oxo, -CI, -N0 2 , -CN, -N 3 , C2-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3- i 5 cycloalkyl, C2-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-
  • R 12 -C(0)R 12 , -C(0)0-R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )- C(0)R 12 , -N(R 12 )C(0)0(R 12 ), -N(R 12 )C(0)N(R 12 )( R 12 ), -N(R 12 )S(0) 2 (R 12 ), -N(R 12 )S(0) 2 - N(R 12 )( R 12 ), -N(R 12 )S(0) 2 0(R 12 ), -OC(0)R 12 , -OC(0)OR 12 , -OC(O)- N(R 12 )( R 12 ), -Si(R 12 ) 3 , -S-R 12 , -S(0)R 12 , -S(0)(NH)R 12 , -S(0) 2 R
  • Ci_6 alkyl is optionally substituted with Z la ; and wherein each said C 2 _9 alkyl, C3-9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C3 5 cycloalkyl, Ci -8 haloalkyl, C 2 _8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Z lb .
  • R 2 is C 4 _6 alkyl substituted with one or more substituents selected from -CI, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, monocyclic heterocyclyl, bicyclic heterocyclyl, -0(C 3 _9 alkyl), -0(C 3- io cycloalkyl), -O(heterocyclyl), -O(aryl), -O(heteroaryl), -C(0)-R 12 , -C(0)0-R 12 , -C(O)- N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)(C 4 _ 9 alkyl),
  • R 2 is C 4 _6 alkyl substituted with one or more -0(CH 2 ) 2 R 17 or -0(CH 2 )R 17 ;
  • R 17 at each occurrence is independently C 3 -15 cycloalkyl, aryl, heterocyclyl, heteroaryl, -O-R 12 , -C(0)-R 12 , -C(0)0-R 12 , -C(0)-N(R 12 )( R 12 ), - N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R 12 , - N(R 12 )C(0)N(R 12 )( R 12 ), -N(R 12 )S(0) 2 (R 12 ), -NR 12 S(0) 2 N(R 12 ),
  • R 2 is C 4 _ 6 alkyl substituted with five or more substituents selected from F, hydroxyl, -CN, -OCH 3 , -OCD 3 , -NHC(0)(Ci_ 3 alkyl), - S(0) 2 (Ci_3 alkyl), or Ci -2 fluoroalkoxy; and wherein said C 4 _ 6 alkyl is optionally substituted with Z 1 .
  • R 2 is Ci_3 alkyl substituted with one or more substituents selected from -CI, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, cyclopropyl, napthyl, bicyclic heterocyclyl, C 7-15 cycloalkyl, -0(CH 2 ) 2 R 17 , -0(CH 2 )R 17 , -0(C 3-9 alkyl), -O(C 3-10 cycloalkyl), -O(heterocyclyl), -O(aryl), -O(heteroaryl), -C(0)(Ci -9 alkyl), - C(0)(cyclopropyl), -C(0)0-R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 ) 2
  • Ci -3 alkyl is also optionally substituted with Z 1 ; and wherein said C2-6 alkenyl, C2-6 alkynyl, cyclopropyl, napthyl, bicyclic heterocyclyl,C7_i5 cycloalkyl , -0(C 3 _g alkyl), -0(C 3 _io cycloalkyl), -O(heterocyclyl), -O(aryl), - O(heteroaryl), -N(R 12 )C(0)(C 4 _ 9 alkyl), -N(R 12 )C(0)(C 3 -io cycloalkyl), -N(R 12 )C(0)( heterocyclyl), -N(R 12 )C(0)(aryl), -N(R 12 )C(0)(heteroaryl), -S(0) 2 (C 4 _ 9 alkyl), - S(0) 2 (aryl), -S(0) 2 (C 4 _
  • R is O O 0 r
  • R 2 is C1-3 alkyl substituted with one or more substituents selected from azetidinyl, tetrahydrofuranyl, triazolyl, oxazolyl, isoxazolyl, thiadiazole, oxadiazole, pyrimidinyl, pyridizinyl, pyrazinyl, isothiazolyl, tetrazolyl, furanyl, thiomorpholinyl, 4-7 membered sultam, 4-7 membered cyclic carbamate, 4-7 membered cyclic carbonate, 4-7 membered cyclic sulfide, or 8-10 membered heteroaryl; any of which is optionally substituted with Z la ; and wherein said C1-3 alkyl is also optionally substituted with Z 1 .
  • R 2 is
  • R 2 is C1-3 alkyl substituted with one substituent selected from phenyl, oxetanyl, tetrahydropyranyl, morpholinyl, piperidinyl, imidazolyl, pyridinyl, thiophenyl, or C 4 _ 6 cycloalkyl ;
  • phenyl, oxetanyl, tetrahydropyranyl, morpholinyl, piperidinyl, imidazolyl, pyridinyl, thiophenyl, or C 4 _ 6 cycloalkyl is substituted with one or more oxo, -N0 2 , -N3, - CN, C4-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3 5 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -0(C 3 _ 6 alkyl), -0(C 3 _ 6 cycloalkyl), -O(heterocyclyl), -C(0)-R 12 , - C(0)0-R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 )
  • heterocyclyl is optionally substituted with Z la .
  • R 2 is C1-3 alkyl optionally substituted with Z 1 and is substituted with one substituent selected from phenyl, oxetanyl, tetrahydropyranyl, morpholinyl, piperidinyl, imidazolyl, pyridinyl, thiophenyl, or C 4 _ 6 cycloalkyl;
  • phenyl, oxetanyl, tetrahydropyranyl, morpholinyl, piperidinyl, imidazolyl, pyridinyl, thiophenyl, or C 4 _6 cycloalkyl is substituted with four or more substituents selected from -F, -CI, -OH, C 1-3 alkyl, -0(d_ 2 alkyl) or -S(0) 2 NH 2 .
  • R 2 is C1-3 alkyl substituted with oxo and optionally substituted with one or more substituents selected from halo, azetidinyl, pyrrolidinyl, piperazinyl, tetrahydrofuranyl, thiomorpholinyl, -CN, C1-9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, cyclopropyl, C 7- i 5 cycloalkyl, Ci -8 haloalkyl, -O-R 12 , -C(0)-R 12 , - C(0)0-R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)- R 12 ,
  • C1-9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, cyclopropyl, C 7- i 5 cycloalkyl, Ci -8 haloalkyl, azetidinyl, pyrrolidinyl, piperazinyl, tetrahydrofuranyl, or thiomorpholinyl is optionally substituted with Z la .
  • R 2 is C 3 alkyl substituted with five or more substituents selected from -F, -OH, -OCH 3 , -CN, -NHC(0)(Ci_ 3 alkyl), Ci_ 2
  • R 2 is C3-10 cycloalkyl optionally substituted with Z of
  • R 2 is
  • R 2 is cyclopropyl optionally substituted with
  • R 2 is C7-10 cycloalkyl optionally substituted with Z
  • R is HO ; HO 0 r
  • R 2 is C 4 _ 6 cycloalkyl substituted with one or more substituents selected from -halo, oxo, -CN, Ci_ 4 alkyl, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -0(C 4 _9 alkyl), - 0(C 3 -io cycloalkyl), -O(heterocyclyl), -O(aryl), -O(heteroaryl), -N(R 12 )C(0)(C 5 - 9 alkyl), -N(
  • R 2 is C 4 _6 cycloalkyl substituted with one or more substituents selected from Ci_ 4 hydroxyalkyl, C1-3 alkoxy, -(CH2)i- 3 0(Ci_3 alkyl), - C(0)NH(d_ 4 alkyl), -C(0)NH(C 3 - 6 cycloalkyl), -N(C 1-3 alkyl) 2 , -NHC(0)0(C 1-3 alkyl), - NHC(0)(Ci_ 4 hydroxyalkyl); wherein said C 4 _ 6 cycloalkyl is optionally substituted with Z 1 ;
  • Ci_ 3 alkoxy, -(CH 2 )i- 3 0(Ci_3 alkyl), -N(C 1-3 alkyl) 2 , -NHC(0)0(Ci_ 3 alkyl) is substituted with oxo, halo, -NO2, -CN, -N 3 , C 3 -9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3- i 5 cycloalkyl, Ci_ 8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 12 , -C(0)R 12 , -C(0)0- R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )-C(0)R 12 , - N(R 12 )C(0)0(R 12 ), -N(R 12 ),
  • C(0)NH(Ci_ 4 alkyl) is substituted with oxo, halo, -N0 2 , -CN, -N 3 , C 4 _ 9 alkyl, C 2 - 6 alkenyl, C2-6 alkynyl, C 3- i 5 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R 12 , -C(0)R 12 , -C(0)0-R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )- C(0)R , -N(R 1Z )C(0)0(R 1Z ), -N(R 1Z )C(0)N(R 1Z )( R 1Z ), - N(R 12 )S(0) 2 (R 12 ), -N(R 12
  • R 2 is
  • R 2 is C 4 _6 cycloalkyl substituted with one or more -NHC(0)(Ci_ 3 alkyl); wherein at least one -NHC(0)(Ci_ 3 alkyl) is substituted with one or more oxo, halo, -N0 2 , -CN, -N3, C 3 -9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3 -15 cycloalkyl, Ci_ 8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 9 , -C(0)R 12 , -C(0)0- R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )
  • C 3 -9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C3 5 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Z la .
  • R 2 is in another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R 2 is C 4 _6 cycloalkyl substituted with three or more substituents selected from -OH, Ci_ 4 hydroxyalkyl, C1-3 alkoxy, -(CH2)i- 3 0(Ci_ 3 alkyl), -C(0)NH(Ci_ 4 alkyl), -C(0)NH(C 3 - 6 cycloalkyl), -N(C 1-3 alkyl) 2 , -NHC(0)(Ci_ 3 alkyl), -NHC(0)0(Ci_ 3 alkyl), or -NHC(0)(Ci_ 4 hydroxyalkyl); and wherein said C 4 _ 6 cycloalkyl is optionally substituted with Z 1 .
  • R 2 is s 5-10 membered heteroaryl optionally substituted with Z 1 .
  • R 2 is oxazolyl, isoxazolyl, thiadiazole, thiazole, oxadiazole, isothiazolyl, tetrazolyl, thiophenyl, furanyl, or a 6-10 membered heteroaryl; any of which is optionally substituted with Z 1 ;
  • R 2 is 4-7 membered monocyclic
  • heterocyclyl optionally substituted with Z 1 .
  • R 2 is ⁇ ⁇ f , 0 ° ⁇ ? Struktur or ⁇ 0 3 ⁇ 4
  • R 2 is azetidinyl, oxetanyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, 4-7 membereded sultam, 4-7 membered cyclic carbamate, 4-7 membered cyclic carbonate, or 4-7 membered cyclic sulfide; any of which is optionally substituted with Z 1 .
  • R 2 is azetidinyl, oxetanyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, 4-7 membereded sultam, 4-7 membered cyclic carbamate, 4-7 membered cyclic carbonate, or 4-7 membered cyclic sulfide; any of which is optionally substituted with Z 1 .
  • R 2 is
  • R 2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl;
  • tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more substituents selected from oxo, halo, -CN, C2-4 alkyl, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3 -15 cycloalkyl, Ci_ 8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 12 , -C(0)-R 12 , -C(0)0-R 12 , -C(O)- N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R 12 , - N(R 12
  • tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is optionally substituted with Z la ;
  • C2-4 alkyl is optionally substituted with halo, -NO2, -CN, -N3, alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3 -15 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl,
  • R 2 is
  • R 2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl;
  • tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more Ci alkyl;
  • tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is optionally substituted with Z 1 ;
  • Ci alkyl is optionally substituted with oxo, halo, -NO2, -CN, -N 3 , C2-6 alkenyl, C2-6 alkynyl, C 3 -15 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R 9 , -C(0)R 12 , -C(0)0-R 12 , -C(0)N(R 9 )( R 9 ), - C(0)N(R 12 )(C 4 _ 9 alkyl), - C(0)N(R 12 )(C 3 - 10 cycloalkyl), - C(0)N(R 12 )(heterocyclyl), - C(0)N(R 12 )(aryl), - C(0)N(R 12 )(heteroaryl), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )
  • R 2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl; any of which is optionally substituted with Z 1 ; wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more S(0) 2 (Ci_3 alkyl); wherein said S(0) 2 (Ci_3 alkyl) is substituted with oxo, halo, -N0 2 , -CN, -N 3 , C 3 -9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3
  • R 12 -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )-C(0)R 12 , - N(R 1Z )C(0)0(R 1Z ), -N(R 1Z )C(0)N(R 1Z )( R 1Z ), -N(R 1Z )S(0) 2 (R ), -N(R 1Z )S(0) 2 - N(R 12 )( R 12 ), -N(R 12 )S(0) 2 0(R 12 ), -OC(0)R 12 , -OC(0)OR 12 , -OC(O)- N(R 12 )( R 12 ), -Si(R 12 ) 3 , -S-R 12 , -S(0)R 12 , -S(0)(NH)R 12 , -S(0) 2 R 12 or -S(0) 2 N(R 12
  • R 2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl; any of which is optionally substituted with Z 1 ; wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more C1-4 hydroxyalkyl; wherein said C1-4 hydroxyalkyl is substituted with oxo, halo, -N0 2 , -CN, -N 3 , C 4 _ 9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3 _i 5 cycloalky
  • R 2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl; any of which is optionally substituted with Z 1 ; wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more -CH 2 C(0)NH(Ci_ 6 alkyl); wherein said -CH 2 C(0)NH(Ci_ 6 alkyl) is substituted with oxo, -CI, -N0 2 , -CN, -N3, C 6 -9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkyn
  • R 2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl;
  • tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more -CH2C(0)NH(C4_6 alkyl); and wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is optionally substituted with Z 1 .
  • R 2 is C 6 -io aryl optionally substituted with
  • R 2 is 6-12 membered bicyclic heterocyclyl optionally substituted with Z 1 ; wherein when said 6-12 membered bicyclic heterocyclyl is l-oxa-7-azaspiro[3.5]nonanyl, then said l-oxa-7-azaspiro[3.5]nonanyl is substituted with one or more Z .
  • R 2 is .
  • R 2 is -N(R 12 )( R 12 ), -S(0) 2 R 12 , -S(0) 2 N(R 12 )( R 12 ); or -H.
  • R 2 is -N(R 12 )( R 12 ), -S(0) 2 R 12 , -S(0) 2 N(R 12 )( R 12 ); or -H.
  • R 2 is -N(R 12 )( R 12 ), -S(0) 2 R 12 , -S(0) 2 N(R 12 )( R 12 ); or -H.
  • R 2 is
  • R 3 is selected from H, halo, -NO2, -CN, -O- R 12 , -C(0)-R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R 12 , -N(R 12 )S(0) 2 (R 12 ), -N(R 12 )C(0)-N(R 12 )( R 12 ), -S(0) 2 R 12 ), -SR 12 and -S(0) 2 N(R 12 )( R 12 ).
  • R 3 is selected from -O-R 12 , -C(O)- R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 9 )( R 9 ), -NH(R 9 ), -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R 12 , - N(R 12 )S(0) 2 (R 12 ), -N(R 12 )C(0)-N(R 12 )( R 12 ), -S(0) 2 (R 12 ), -S-R 12 or -S(0) 2 N(R 12 )( R 12 ); wherein when said -N(H)(R 9 ) is NH(Ci_ 3 alkyl), -N(H)(R 9 ) is NH(Ci_ 4 hydroxy alkyl), or -O-R 12 is -0
  • C 4 _9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C3 5 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Z la .
  • R 3 is in another embodiment, a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R 3 is selected from -0(C 4 alkyl) or -N(H)(C 4 alkyl); wherein said -0(C 4 alkyl) is optionally substituted with Z la ; wherein said - N(H)(C 4 alkyl) is optionally substituted with oxo, halo, -N0 2 , -CN, -N 3 , Ci_ 9 alkyl, C 2 -6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R 9 , -C(0)R 12 , -C(0)0-R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 )( R
  • R 3 is C1-9 alkyl optionally substituted with Z 1 .
  • R 3 is Ci -2 alkyl optionally substituted with F and further substituted with one or more oxo, -CI, -N0 2 , -N3, -CN, C 3 -9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3 -15 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R 12 , -C(0)-R 12 , -C(0)0-R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 12 )( R 12 ), - N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R 12 , -N(R 12 )C(0)N(R 12 , -N(R 12 )C(0)N(N(R 12 )C(0)N(R 12 ,
  • C 3 -9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3 -15 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Z la .
  • R 3 is In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R 3 is In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R 3 is C3 alkyl substituted with one or more Z In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R 3 is C4-9 alkyl optionally substituted with Z
  • R 3 is C2-9 alkynyl optionally substituted with Z 1 .
  • R 3 is In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R 3 is C2-9 alkenyl optionally substituted with Z 1 .
  • R 3 is a 5-10 membered heteroaryl optionally substituted with Z 1 .
  • R 3 is a 5-10 membered heteroaryl optionally substituted with Z 1 ; wherein if said 5-10 membered heteroaryl is pyridinyl, then said pyridinyl is further substituted with one or more Z 1 .
  • R 3 is C 6 -io aryl optionally substituted with In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R 3 is C 6 -io aryl optionally substituted with Z 1 ;
  • R 3 is a 4-12 membered heterocyclyl optionally substituted with Z 1 .
  • R 3 is a 4-12 membered heterocyclyl optionally substituted with Z 1 ; wherein when said 4-12 membered heterocyclyl is hydroxypyrrolidinyl then said hydroxypyrrolidinyl is further substituted with one or more oxo, halo, -CN, -N0 2 , -N3, C1-9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3 -15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 9 , -C(0)R 12 , -C(0)0- R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R
  • R 3 is C3-10 cycloalkyl optionally substituted with Z
  • R 3 is C3_ 6 cycloalkyl substituted with one or more Z 1 .
  • R 3 is C 7- io cycloalkyl optionally substituted with Z
  • R 4 is H, halo, -NO2, -CN, -O-R 12 , -C(O)- R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 12 )( R 12 ), -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R 12 , - N(R 12 )S(0) 2 (R 12 ), -N(R 12 )C(0)-N(R 12 )( R 12 ), -S(0) 2 R 12 ), -SR 12 or -S(0) 2 N(R 12 )( R 12 ).
  • R is a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof.
  • R 4 is -O-R 12 , -C(0)-R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 9 )( R 9 ), -NH(R 9 ), -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R 12 , -
  • R 4 is selected from -0(C 4 alkyl) or -N(H)(C 4 alkyl); wherein said -0(C 4 alkyl) is optionally substituted with Z la ;
  • -N(H)(C 4 alkyl) is optionally substituted with oxo, halo, -NO2, -CN, -N 3 , Ci-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3 -15 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 9 , -C(0)R 12 , -C(0)0-R 12 , -C(0)N(R 12 )( R 12 ), -N(R 12 )(V), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )-C(0)R 12 , -N(R 12 )C(0)0(R 12 ), -N(R 12 )C(0)N(R 12 )( R 12 ), - N(R 12 )S(0) 2 (R 12 ), -N(R 12 )S(0) 2 (R 12 ), -N
  • R 4 is C1-9 alkyl optionally substituted with Z 1 .
  • R 4 is Ci -2 alkyl optionally substituted with F and further substituted with one or more oxo, -CI, -N0 2 , -N 3 , -CN, C 3 -9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C 3 -15 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R 12 , -C(0)-R 12 , -C(0)0-R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 12 )( R 12 ), - N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R 12 , -N(R 12 )C(0)N(R 12 , -N(R 12 )C(0)N(R 12 , -N(R 12 )C(0)N(
  • R 4 is C 3 alkyl substituted with one or more In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R 4 is C 4 _g alkyl optionally substituted with Z In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R 4 is C2-9 alkynyl optionally substituted with
  • R 4 is C2-9 alkenyl optionally substituted with Z 1 .
  • R 4 is a 5-10 membered heteroaryl optionally substituted with Z 1 .
  • R 4 is
  • R 4 is a 5-10 membered heteroaryl optionally substituted with Z 1 ; wherein when said 5-10 membered heteroaryl is pyridinyl then said pyridinyl is further substituted with one or more Z 1 .
  • R 4 is C 6 -io aryl optionally substituted with Z 1 .
  • R 4 is C 6 -io aryl optionally substituted with Z 1 ; wherein when said C 6 -io aryl is cyanophenyl then said cyanophenyl is further substituted with one or more oxo, halo, -NO2, -N3, Ci_g alkyl, C2-6 alkenyl, C2-6 alkynyl, C3 5 cycloalkyl, Ci_ 8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 12 , -C(0)R 12 , -C(0)0- R 12 , -C(0)N(R 12 )( R 12 ),
  • R 4 is a 4-12 membered heterocyclyl optionally substituted with Z 1 .
  • R 4 is a 4-12 membered heterocyclyl optionally substituted with Z 1 ; wherein when said 4-12 membered heterocyclyl is hydroxypyrrolidinyl then said hydroxypyrrolidinyl is further substituted with one or more oxo, halo, -CN, -N0 2 , -N3, C1-9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3 -15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 9 , -C(0)R 12 , -C(0)0-
  • R 4 is C3-10 cycloalkyl optionally substituted with Z
  • R 4 is C 3 -6 cycloalkyl substituted with one or more Z 1 .
  • R 4 is C 7- io cycloalkyl optionally substituted with Z
  • R 5 , R 6 or R 7 is independently selected from H, halo, -N0 2 , -CN, -O-R 12 , -C(0)-R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 9 )( R 9 ), NH(R 9 ), -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R 12 , or -N(R 12 )S(0) 2 (R 12 ).
  • At least one of R 5 , R 6 or R 7 is independently selected from -N0 2 , -O-R 12 , -C(0)-R 12 , -C(0)-N(R 12 )( R 12 ), -N(R 9 )( R 9 ), -N(R 12 )C(0)- R 12 , -N(R 12 )C(0)0-R 12 , or -N(R 12 )S(0) 2 (R 12 ).
  • R 5 , R 6 or R 7 is independently Ci-5 alkyl optionally substituted with Z 1 .
  • R 5 , R 6 or R 7 is independently Ci -2 alkyl optionally substituted with F and substituted with one or more oxo, -CI, -N0 2 , - N 3 , -CN, C 3 _9 alkyl, C 2 _ 6 alkenyl, C 2 _ 6 alkynyl, C 3- i 5 cycloalkyl, Ci -8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 12 , -C(0)-R 12 , -C(0)0-R 12 , -C(0)-N(R 12 )( R 12 ), - N(R 12 )( R 12 ), -N(R 12 ) 2 (R 12 ) + , -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R
  • R 5 , R 6 or R 7 is independently C 3 alkyl substituted with one or more Z 1 .
  • at least one of R 5 , R 6 or R 7 is independently C4-5 alkyl optionally substituted with Z 1 .
  • R 5 , R 6 or R 7 is independently cyclopropyl, oxetanyl, or azetidinyl optionally substituted with Z 1 .
  • R 5 , R 6 or R 7 is independently cyclopropyl, oxetanyl, or azetidinyl; wherein said cyclopropyl is substituted with one or more Z 1 ; wherein said oxetanyl or azetidinyl is optionally substituted with Z 1 .
  • no more than two of R 3 , R 4 , R 5 , R 6 or R 7 are H.
  • R 3 is H or F.
  • R 4 is H, F, -CN or CI.
  • R 5 is H or F.
  • R 6 is H or F.
  • R 7 is H or F.
  • Z 1 is selected H, halo, -CN, Ci_g alkyl, C3_i5 cycloalkyl, aryl, heteroaryl, heterocyclyl, -O-R 12 , -C(0)-R 12 , -C(0)-N(R 12 )( R 12 ), - N(R 12 )( R 12 ), -N(R 12 )C(0)-R 12 , -N(R 12 )C(0)0-R 12 , -N(R 12 )S(0) 2 (R 12 ), -OC(0)-N(R 12 )( R 12 ), -S(0) 2 R 12 or -S(0) 2 N(R 12 )( R 12 ); and
  • any alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Z la .
  • Another embodiment of the present disclosure provides a pharmaceutical composition
  • a pharmaceutical composition comprising a compound of the disclosure, together with a pharmaceutically acceptable carrier, and optionally a diluent.
  • Another embodiment of the present disclosure provides a method of treating an inflammation related disease or disorder in a patient in need thereof, comprising administering to said patient a compound of the disclosure, or a pharmaceutical composition thereof.
  • a dash (“-") that is not between two letters or symbols is used to indicate a point of attachment for a substituent.
  • -C(0)NH 2 is attached through the carbon atom.
  • a dash at the front or end of a chemical group is a matter of convenience;
  • chemical groups may be depicted with or without one or more dashes without losing their ordinary meaning.
  • a wavy line drawn through a line in a structure indicates a point of attachment of a group. Unless chemically or structurally required, no directionality is indicated or implied by the order in which a chemical group is written or named.
  • the prefix "C u _ v " indicates that the following group has from u to v carbon atoms. For example, "Ci_ 6 alkyl” indicates that the alkyl group has from 1 to 6 carbon atoms.
  • references to "about” a value or parameter herein includes (and describes) embodiments that are directed to that value or parameter per se.
  • the term “about” includes the indicated amount + 10%.
  • the term “about” includes the indicated amount + 5%.
  • the term “about” includes the indicated amount ⁇ 1%.
  • to the term “about X” includes description of "X”.
  • the singular forms "a” and “the” include plural references unless the context clearly dictates otherwise.
  • reference to “the compound” includes a plurality of such compounds and reference to “the assay” includes reference to one or more assays and equivalents thereof known to those skilled in the art.
  • alkyl refers to an unbranched or branched saturated hydrocarbon chain. As used herein, alkyl has 1 to 20 carbon atoms (i.e., Ci_2o alkyl), 1 to 8 carbon atoms (i.e., Ci-8 alkyl), 1 to 6 carbon atoms (i.e. , Ci_6 alkyl), or 1 to 4 carbon atoms (i.e. , C1-4 alkyl).
  • alkyl groups include methyl, ethyl, propyl, isopropyl, n-butyl, sec -butyl, iso-butyl, tert-butyl, pentyl, 2-pentyl, isopentyl, neopentyl, hexyl, 2-hexyl, 3-hexyl, and 3-methylpentyl.
  • alkyl residue having a specific number of carbons is named by chemical name or identified by molecular formula, all positional isomers having that number of carbons may be encompassed; thus, for example, "butyl” includes n-butyl (i.e.
  • Alkenyl refers to an alkyl group containing at least one carbon-carbon double bond and having from 2 to 20 carbon atoms (i.e. , C 2 _ 2 o alkenyl), 2 to 8 carbon atoms (i.e. , C 2 _8 alkenyl), 2 to 6 carbon atoms (i.e. , C 2 _ 6 alkenyl), or 2 to 4 carbon atoms (i.e. , C 2 _ 4 alkenyl).
  • alkenyl groups include ethenyl, propenyl, butadienyl (including 1,2-butadienyl and 1,3 -butadienyl).
  • Alkynyl refers to an alkyl group containing at least one carbon-carbon triple bond and having from 2 to 20 carbon atoms (i.e., C 2 _ 2 o alkynyl), 2 to 8 carbon atoms (i.e. , C 2 _8 alkynyl), 2 to 6 carbon atoms (i.e. , C 2 _ 6 alkynyl), or 2 to 4 carbon atoms (i.e., C 2 _ 4 alkynyl).
  • alkynyl also includes those groups having one triple bond and one double bond.
  • Alkoxy refers to the group “alkyl-O-”. Examples of alkoxy groups include methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, tert-butoxy, sec-butoxy, n-pentoxy, n-hexoxy, and 1,2-dimethylbutoxy.
  • Haloalkoxy refers to an alkoxy group as defined above, wherein one or more hydrogen atoms are replaced by a halogen.
  • Alkylthio refers to the group “alkyl-S-”.
  • Amino refers to the group -NR y R y wherein each R y is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, cycloalkyl or heteroaryl, each of which is optionally substituted, as defined herein.
  • Aryl refers to an aromatic carbocyclic group having a single ring (e.g.
  • aryl has 6 to 20 ring carbon atoms (i.e. , C 6 -2o aryl), 6 to 12 carbon ring atoms (i.e. , C 6 -i2 aryl), or 6 to 10 carbon ring atoms (i.e. , C 6 -io aryl).
  • aryl groups include phenyl, naphthyl, fluorenyl, and anthryl. Aryl, however, does not encompass or overlap in any way with heteroaryl defined below. If one or more aryl groups are fused with a heteroaryl, the resulting ring system is heteroaryl. If one or more aryl groups are fused with a heterocyclyl, the resulting ring system is heterocyclyl.
  • Cyano refers to the group -CN.
  • Carbamoyl refers to both an "O-carbamoyl” group which refers to the group - 0-C(0)NR y R z and an "N-carbamoyl” group which refers to the group -NR y C(0)OR z , wherein R y and R z are independently selected from the group consisting of hydrogen, alkyl, aryl, haloalkyl, or heteroaryl; each of which may be optionally substituted.
  • Carboxyl refers to -C(0)OH.
  • “Ester” refers to both -OC(0)R and -C(0)OR, wherein R is a substituent; each of which may be optionally substituted, as defined herein.
  • “Cycloalkyl” refers to a saturated or partially unsaturated cyclic alkyl group having a single ring or multiple rings including fused, bridged, and spiro ring systems.
  • the term “cycloalkyl” includes cycloalkenyl groups (i.e. the cyclic group having at least one double bond). As used herein, cycloalkyl has from 3 to 20 ring carbon atoms (i.e. , C3- 20 cycloalkyl), 3 to 12 ring carbon atoms (i.e.
  • C 3- i 2 cycloalkyl 3 to 10 ring carbon atoms (i.e. , C 3- io cycloalkyl), 3 to 8 ring carbon atoms (i.e. , C 3 _8 cycloalkyl), or 3 to 6 ring carbon atoms (i.e. , C 3 _6 cycloalkyl).
  • cycloalkyl groups include cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl.
  • Halogen or “halo” includes fluoro, chloro, bromo, and iodo.
  • Haloalkyl refers to an unbranched or branched alkyl group as defined above, wherein one or more hydrogen atoms are replaced by a halogen. For example, where a residue is substituted with more than one halogen, it may be referred to by using a prefix corresponding to the number of halogen moieties attached.
  • Dihaloalkyl and trihaloalkyl refer to alkyl substituted with two ("di") or three (“tri") halo groups, which may be, but are not necessarily, the same halogen. Examples of haloalkyl include difluoromethyl (-CHF 2 ) and trifluoromethyl (-CF 3 ).
  • Heteroalkyl refers to an alkyl group in which one or more of the carbon atoms (and any associated hydrogen atoms) are each independently replaced with the same or different heteroatomic group.
  • the term “heteroalkyl” includes unbranched or branched saturated chain having carbon and heteroatoms. By way of example, 1, 2 or 3 carbon atoms may be independently replaced with the same or different heteroatomic group.
  • Heteroatomic groups include, but are not limited to, -NR-, -0-, -S-, -S(O)-, -S(0) 2 -, and the like, where R is H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted.
  • R is H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted.
  • heteroalkyl groups include - OCH 3 , -CH 2 OCH 3 , -SCH 3 , -CH 2 SCH 3 , -NRCH 3 , and -CH 2 NRCH 3 , where R is hydrogen, alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl, each of which may be optionally substituted.
  • heteroalkyl include 1 to 10 carbon atoms, 1 to 8 carbon atoms, or 1 to 4 carbon atoms; and 1 to 3 heteroatoms, 1 to 2 heteroatoms, or 1 heteroatom.
  • Heteroaryl refers to an aromatic group having a single ring, multiple rings, or multiple fused rings, with one or more ring heteroatoms independently selected from nitrogen, oxygen, and sulfur.
  • heteroaryl includes 1 to 20 ring carbon atoms (i.e. , Ci -20 heteroaryl), 3 to 12 ring carbon atoms (i.e. , C 3- i 2 heteroaryl), or 3 to 8 carbon ring atoms (i.e.
  • heteroaryl groups include pyrimidinyl, purinyl, pyridyl, pyridazinyl, benzothiazolyl, and pyrazolyl.
  • fused- heteroaryl rings include, but are not limited to, benzo[d]thiazolyl, quinolinyl, isoquinolinyl, benzo[b]thiophenyl, indazolyl, benzo[d]imidazolyl, pyrazolo[l,5- ajpyridinyl, and imidazo[l,5-a]pyridinyl, where the heteroaryl can be bound via either ring of the fused system. Any aromatic ring, having a single or multiple fused rings, containing at least one heteroatom, is considered a heteroaryl regardless of the attachment to the remainder of the molecule (i.e., through any one of the fused rings). Heteroaryl does not encompass or overlap with aryl as defined above.
  • Heterocyclyl refers to a saturated or unsaturated cyclic alkyl group, with one or more ring heteroatoms independently selected from nitrogen, oxygen and sulfur.
  • the term “heterocyclyl” includes heterocycloalkenyl groups (i.e. the heterocyclyl group having at least one double bond), bicyclic heterocyclyl groups, bridged-heterocyclyl groups, fused-heterocyclyl groups, and spiro-heterocyclyl groups.
  • a heterocyclyl may be a single ring or multiple rings wherein the multiple rings may be fused, bridged, or spiro.
  • heterocyclyl any non-aromatic ring containing at least one heteroatom is considered a heterocyclyl, regardless of the attachment (i.e., can be bound through a carbon atom or a heteroatom).
  • heterocyclyl is intended to encompass any non-aromatic ring containing at least one heteroatom, which ring may be fused to an aryl or heteroaryl ring, regardless of the attachment to the remainder of the molecule.
  • heterocyclyl has 2 to 20 ring atoms (i.e. , 4-20 membered heterocyclyl), 2 to ring atoms (i.e. , 4-12 membered heterocyclyl), 4 to 10 ring atoms (i.e., 4-10 membered
  • heterocyclyl 4 to 8 ring atoms (i.e. , 4-8 membered heterocyclyl), or 4 to 6 ring carbon atoms (i.e. , 4-6 membered heterocyclyl); having 1 to 5 ring heteroatoms, 1 to 4 ring heteroatoms, 1 to 3 ring heteroatoms, 1 to 2 ring heteroatoms, or 1 ring heteroatom independently selected from nitrogen, sulfur or oxygen.
  • a heterocyclyl may contain one or more oxo and/or thioxo groups. Examples of heterocyclyl groups include
  • bridged- heterocyclyl refers to a four- to ten-membered cyclic moiety connected at two non-adjacent atoms of the heterocyclyl with one or more (e.g.
  • bridged- heterocyclyl includes bicyclic and tricyclic ring systems.
  • spiro-heterocyclyl refers to a ring system in which a three- to ten-membered heterocyclyl has one or more additional ring, wherein the one or more additional ring is three- to ten-membered cycloalkyl or three- to ten-membered heterocyclyl, where a single atom of the one or more additional ring is also an atom of the three- to ten- membered heterocyclyl.
  • spiro-heterocyclyl rings examples include bicyclic and tricyclic ring systems, such as 2-oxa-7-azaspiro[3.5]nonanyl, 2-oxa-6- azaspiro[3.4]octanyl, and 6-oxa-l-azaspiro[3.3]heptanyl.
  • fused- heterocyclyl rings include, but are not limited to, 1,2,3, 4-tetrahydroisoquinolinyl, 1-oxo- 1,2,3,4-tetrahydroisoquinolinyl, l-oxo-l,2-dihydroisoquinolinyl, 4,5,6,7- tetrahydrothieno[2,3-c]pyridinyl, indolinyl, and isoindolinyl, where the heterocyclyl can be bound via either ring of the fused system.
  • a bicyclic heterocyclyl group is a heterocyclyl group attached at two points to another cyclic group, wherein the other cyclic group may itself be a heterocyclic group, or a carbocyclic group.
  • nitrogen or sulfur containing heterocyclyl means a heterocyclyl moiety that contains at least one nitrogen atom or at least one sulfur atom, or both a nitrogen atom and a sulfur atom within the ring structure. It is to be understood that other heteroatoms, including oxygen, may be present in addition to the nitrogen, sulfur, or combinations thereof.
  • nitrogen or sulfur containing heterocyclyls include morpholinyl, thiomorpholinyl, thiazolyl, isothiazolyl, oxazolidinone 1,2 dithiolyl, piperidinyl, piperazinyl, and the like.
  • Hydroxy or “hydroxyl” refers to the group -OH.
  • Hydrophilic alkyl refers to an unbranched or branched alkyl group as defined above, wherein one or more hydrogen atoms are replaced by a hydroxyl.
  • Niro refers to the group -NO2.
  • Sulfonyl refers to the group -S(0)2R, where R is a substituent, or a defined group.
  • Alkylsulfonyl refers to the group -S(0)2R, where R is a substituent, or a defined group.
  • Alkylsulfinyl refers to the group -S(0)R, where R is a substituent, or a defined group.
  • Thiocyanate -SCN.
  • Thiol refers to the group -SR, where R is a substituent, or a defined group.
  • a divalent group such as a divalent “alkyl” group, a divalent “aryl” group, etc.
  • a divalent group such as a divalent “alkyl” group, a divalent “aryl” group, etc.
  • combinations of groups are referred to herein as one moiety, e.g. arylalkyl, the last mentioned group contains the atom by which the moiety is attached to the rest of the molecule.
  • heteroaryl then the general term can refer to any antecedent specifically recited term, such as (Ci-3 alkyl), (C4-6 alkyl), -0(Ci_4 alkyl), (C 3 -1 0 cycloalkyl), 0-(C 3 _io cycloalkyl) and the like.
  • any aryl includes both “aryl” and “-O(aryl) as well as examples of aryl, such as phenyl or naphthyl and the like.
  • any heterocyclyl includes both the terms “heterocyclyl” and O-(heterocyclyl),” as well as examples of heterocyclyls, such as oxetanyl, tetrahydropyranyl, morpholino, piperidinyl and the like.
  • any heteroaryl includes the terms
  • heteroaryl and “O-(heteroryl),” as well as specific heteroaryls, such as pyridine and the like.
  • Tautomers are in equilibrium with one another.
  • amide containing compounds may exist in equilibrium with imidic acid tautomers. Regardless of which tautomer is shown, and regardless of the nature of the equilibrium among tautomers, the compounds are understood by one of ordinary skill in the art to comprise both amide and imidic acid tautomers. Thus, the amide containing compounds are understood to include their imidic acid tautomers. Likewise, the imidic acid containing compounds are understood to include their amide tautomers.
  • isotopes that can be incorporated into compounds of the disclosure include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorous, fluorine and chlorine, such as, but not limited to 2 H (deuterium, D), 3 H (tritium), n C, 13 C, 14 C, 15 N,
  • isotopically labeled compounds of the present disclosure for example those into which radioactive isotopes such as 3 H, 13 C and 14 C are incorporated.
  • isotopically labelled compounds may be useful in metabolic studies, reaction kinetic studies, detection or imaging techniques, such as positron emission tomography (PET) or single-photon emission computed tomography (SPECT) including drug or substrate tissue distribution assays or in radioactive treatment of patients.
  • PET positron emission tomography
  • SPECT single-photon emission computed tomography
  • the disclosure also includes "deuterated analogues" of compounds of Formula I in which from 1 to n hydrogens attached to a carbon atom is/are replaced by deuterium, in which n is the number of hydrogens in the molecule.
  • deuterated analogues of compounds of Formula I in which from 1 to n hydrogens attached to a carbon atom is/are replaced by deuterium, in which n is the number of hydrogens in the molecule.
  • Such compounds exhibit increased resistance to metabolism and are thus useful for increasing the half-life of any compound of Formula I when administered to a mammal, particularly a human. See, for example, Foster, “Deuterium Isotope Effects in Studies of Drug Metabolism," Trends Pharmacol. Sci. 5(12):524-527 (1984).
  • Such compounds are synthesized by means well known in the art, for example by employing starting materials in which one or more hydrogens have been replaced by deuterium.
  • Deuterium labelled or substituted therapeutic compounds of the disclosure may have improved DMPK (drug metabolism and pharmacokinetics) properties, relating to distribution, metabolism and excretion (ADME). Substitution with heavier isotopes such as deuterium may afford certain therapeutic advantages resulting from greater metabolic stability, for example increased in vivo half-life, reduced dosage requirements and/or an improvement in therapeutic index.
  • An 18 F labeled compound may be useful for PET or SPECT studies.
  • Isotopically labeled compounds of this disclosure and prodrugs thereof can generally be prepared by carrying out the procedures disclosed in the schemes or in the examples and preparations described below by substituting a readily available isotopically labeled reagent for a non-isotopically labeled reagent.
  • deuterium in this context is regarded as a substituent in the compound of Formula I.
  • concentration of such a heavier isotope, specifically deuterium may be defined by an isotopic enrichment factor.
  • any atom not specifically designated as a particular isotope is meant to represent any stable isotope of that atom.
  • a position is designated specifically as “H” or “hydrogen”, the position is understood to have hydrogen at its natural abundance isotopic composition.
  • any atom specifically designated as a deuterium (D) is meant to represent deuterium.
  • the compounds of this disclosure are capable of forming acid and/or base salts by virtue of the presence of amino and/or carboxyl groups or groups similar thereto.
  • Provided are also pharmaceutically acceptable salts, hydrates, solvates, tautomeric forms, polymorphs, and prodrugs of the compounds described herein.
  • “Pharmaceutically acceptable” or “physiologically acceptable” refer to compounds, salts, compositions, dosage forms and other materials which are useful in preparing a pharmaceutical composition that is suitable for veterinary or human pharmaceutical use.
  • pharmaceutically acceptable salt of a given compound refers to salts that retain the biological effectiveness and properties of the given compound, and which are not biologically or otherwise undesirable.
  • “Pharmaceutically acceptable salts” or “physiologically acceptable salts” include, for example, salts with inorganic acids and salts with an organic acid.
  • the free base can be obtained by basifying a solution of the acid salt.
  • an addition salt particularly a
  • pharmaceutically acceptable addition salt may be produced by dissolving the free base in a suitable organic solvent and treating the solution with an acid, in accordance with conventional procedures for preparing acid addition salts from base compounds. Those skilled in the art will recognize various synthetic methodologies that may be used to prepare nontoxic pharmaceutically acceptable addition salts.
  • Pharmaceutically acceptable acid addition salts may be prepared from inorganic and organic acids. Salts derived from inorganic acids include hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like.
  • Salts derived from organic acids include acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, malic acid, malonic acid, succinic acid, maleic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluene-sulfonic acid, salicylic acid, and the like.
  • pharmaceutically acceptable base addition salts can be prepared from inorganic and organic bases. Salts derived from inorganic bases include, by way of example only, sodium, potassium, lithium, ammonium, calcium and magnesium salts.
  • Salts derived from organic bases include, but are not limited to, salts of primary, secondary and tertiary amines, such as alkyl amines (i.e., NH2(alkyl)), dialkyl amines (i.e., HN(alkyl)2), trialkyl amines (i.e., N(alkyl) 3 ), substituted alkyl amines (i.e., NH2(substituted alkyl)), di(substituted alkyl) amines (i.e., HN(substituted alkyl)2), tri(substituted alkyl) amines (i.e., N(substituted alkyl) 3 ), alkenyl amines (i.e., NH2(alkenyl)), dialkenyl amines (i.e., HN(alkenyl)2), trialkenyl amines (i.e.,
  • suitable amines include, by way of example only, isopropylamine, trimethyl amine, diethyl amine, tri(iso-propyl) amine, tri(n-propyl) amine, ethanolamine, 2-dimethylaminoethanol, piperazine, piperidine, morpholine, N-ethylpiperidine, and the like.
  • substituted means that any one or more hydrogen atoms on the designated atom or group is replaced with one or more substituents other than hydrogen, provided that the designated atom's normal valence is not exceeded.
  • the one or more substituents include, but are not limited to, alkyl, alkenyl, alkynyl, alkoxy, acyl, amino, amido, amidino, aryl, azido, carbamoyl, carboxyl, carboxyl ester, cyano, guanidino, halo, haloalkyl, haloalkoxy, heteroalkyl, heteroaryl, heterocyclyl, hydroxy, hydrazino, imino, oxo, nitro, alkylsulfinyl, sulfonic acid, alkylsulfonyl, thiocyanate, thiol, thione, or combinations thereof.
  • impermissible substitution patterns e.g., methyl substituted with 5 fluorines or heteroaryl groups having two adjacent oxygen ring atoms.
  • impermissible substitution patterns are well known to the skilled artisan.
  • substituted may describe other chemical groups defined herein. Unless specified otherwise, where a group is described as optionally substituted, any substituents of the group are themselves unsubstituted.
  • substituted alkyl refers to an alkyl group having one or more substituents including hydroxyl, halo, alkoxy, cycloalkyl, heterocyclyl, aryl, and heteroaryl.
  • the one or more substituents may be further substituted with halo, alkyl, haloalkyl, hydroxyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl, each of which is substituted.
  • the substituents may be further substituted with halo, alkyl, haloalkyl, alkoxy, hydroxyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, each of which is unsubstituted
  • substituents and other moieties of the compounds of the generic formula herein should be selected in order to provide a compound which is sufficiently stable to provide a pharmaceutically useful compound which can be formulated into an acceptably stable pharmaceutical composition.
  • Compounds which have such stability are contemplated as falling within the scope of the present invention. It should be understood by one skilled in the art that any combination of the definitions and substituents described above should not result in an inoperable species or compound.
  • pharmaceutically acceptable carrier or “pharmaceutically acceptable excipient” includes any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents and the like.
  • the use of such media and agents for pharmaceutically active substances is well known in the art. Except insofar as any conventional media or agent is incompatible with the active ingredient, its use in the therapeutic compositions is contemplated.
  • Supplementary active ingredients can also be incorporated into the compositions.
  • pharmaceutically acceptable carrier or “pharmaceutically acceptable excipient” includes any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents and the like.
  • the use of such media and agents for pharmaceutically active substances is well known in the art. Except insofar as any conventional media or agent is incompatible with the active ingredient, its use in the therapeutic compositions is contemplated.
  • Supplementary active ingredients can also be incorporated into the compositions.
  • a “solvate” is formed by the interaction of a solvent and a compound. Solvates of salts of the compounds described herein are also provided. Hydrates of the compounds described herein are also provided.
  • one aspect of the disclosure is a method of treating an inflammation related disease or condition, or a metabolic disorder, gastrointestinal disorder, or cancer and the like comprising administering a compound of the in combination with one or more compounds useful for the treatment of such diseases to a subject, particularly a human subject, in need thereof.
  • a compound of the present disclosure is co-formulated with the additional one or more active ingredients.
  • the other active ingredient is administered at approximately the same time, in a separate dosage form.
  • the other active ingredient is administered sequentially, and may be administered at different times in relation to a compound of the present disclosure.
  • a compound of the present disclosure may be combined with one or more 5 -Lipoxygenase inhibitors, Acetylcholinesterase inhibitors, ACTH receptor agonists, Activin receptor antagonists, Acyltransferase inhibitors, Adrenocorticotrophic hormone ligands, AKT1 gene inhibitors, Alkaline phosphatase modulators, Alkaline phosphatase stimulators, Androgen receptor agonists, Apolipoprotein C3 antagonists, Bactericidal permeability protein stimulators, Beta adrenoceptor antagonists, Beta- glucuronidase inhibitors, B-lymphocyte antigen CD20 inhibitors, Bradykinin receptor modulators, BTK kinase inhibitors, Calcineurin inhibitors, Calcium channel inhibitors, Cannabinoid CB1 receptor modulators, Cannabinoid CB2 receptor modulators, Cannabinoid receptor antagonists, Cannabinoid receptor modulators, Cathepsin S inhibitors, C
  • Epidermal growth factor ligands Estrogen receptor beta agonists, Factor XIII agonists, FGF- 10 ligands, FGF2 receptor agonists, Fractalkine ligand inhibitors, Free fatty acid receptor 2 antagonists, GATA 3 transcription factor inhibitors, Glucagon-like peptide 2 agonists, Glucocorticoid agonists, GM-CSF receptor agonists, G-protein coupled receptor 84 antagonists, Guanylate cyclase receptor agonists, Histamine H2 receptor antagonists, Histone acetyltransferase inhibitors, Histone deacetylase inhibitors, HLA class II antigen modulators, Hydrolase inhibitors, ICAM1 gene inhibitors, ICAM-1 inhibitors, IL1 gene inhibitors, IL- 10 agonists, IL10 gene stimulators, IL-11 agonists, IL- 12 antagonists, IL 12 gene inhibitors, IL- 13 antagonists, IL- 17 antagonists, IL-2 antagonists,
  • Interleukin- 1 beta ligand modulators Interleukin-6 ligand inhibitors, JAK tyrosine kinase inhibitors, Jakl tyrosine kinase inhibitors, JAK2 gene inhibitors, Jak3 tyrosine kinase inhibitors, Jun N terminal kinase inhibitors, LanC like protein 2 modulators, Leukotriene BLT receptor antagonists, Lipoxygenase modulators, L-Selectin antagonists, MAdCAM inhibitors, Matrix metalloprotease inhibitors, Matrix metalloprotease modulators, Melanocortin agonists, Membrane copper amine oxidase inhibitors, Metalloprotease-2 inhibitors, Metalloprotease-9 inhibitors, MIP 3 alpha ligand inhibitors, Mitochondrial 10 kDa heat shock protein stimulators, Monocyte differentiation antigen CD 14 inhibitors, mTOR inhibitors, Mucin stimulators, NAD- dependent deacetylase sirtuin
  • Neuregulin-4 ligands Nicotinic acetylcholine receptor agonists, Nicotinic ACh receptor alpha 4 subunit modulators, Nicotinic ACh receptor alpha 7 subunit stimulators, Nicotinic ACh receptor beta 2 subunit modulators, NK1 receptor antagonists, NKG2 D activating NK receptor antagonists, Nuclear factor kappa B inhibitors, Opioid growth factor receptor agonists, Opioid receptor antagonists, Opioid receptor delta antagonists, Oxidoreductase inhibitors, P2X7 purinoceptor agonists, p38 MAP kinase inhibitors, PARP inhibitors, PDE 4 inhibitors, PDGF receptor agonists, Phagocytosis stimulating peptide modulators, Phospho MurNAc pentapeptide transferase inhibitors,
  • Phospholipase A2 inhibitors Platelet activating factor receptor antagonists, Potassium channel inhibitors, PPAR alpha agonists, PPAR delta agonists, PPAR gamma agonists, Protein CYR61 stimulators, Protein fimH inhibitors, Protein kinase C alpha inhibitors, Protein kinase C beta inhibitors, Protein kinase C delta inhibitors, Protein kinase C epsilon inhibitors, Protein kinase C eta inhibitors, Protein kinase C theta inhibitors, Protein kinase G inhibitors, Protein kinase inhibitors, P-selectin glycoprotein ligand- 1 inhibitors, PurH purine biosynthesis protein inhibitors, Retinoic acid receptor alpha agonists, Retinoic acid receptor beta agonists, Retinoid receptor agonists, RNA polymerase inhibitors, SMAD-7 inhibitors, Sodium channel inhibitors, Somatostatin receptor receptor
  • Superoxide dismutase stimulators SYK kinase inhibitors, T cell surface glycoprotein CD28 inhibitors, TGF beta 1 ligand inhibitors, Thymulin agonists, TLR-2 antagonists, TLR-4 antagonists, TLR-9 agonists, TNF alpha ligand inhibitors, TNF alpha ligand modulators, TNF antagonists, TPL2 kinase inhibitors, Trefoil factor modulators, Tryptase inhibitors, Tryptophan 5-hydroxylase inhibitors, Tumor necrosis factor 14 ligand modulators, TYK2 kinase inhibitors, Type I TNF receptor antagonists, Type II TNF receptor modulators, Unspecified growth factor receptor modulators, Vanilloid VR1 agonists, Vitamin D3 receptor agonists, Zonulin inhibitors, abatacept; acemannan; adalimumab; DCCT-10; apremilast; AST- 120; balsalazide; balsalazide sodium
  • basiliximab beclomethasone dipropionate; budesonide; D-9421; budesonide MMX; catridecacog; certolizumab pegol; Clostridium butyricum; etanercept; fingolimod;
  • glatiramer acetate golimumab; infliximab; infliximab biosimilar; infliximab follow-on biologic; interferon beta-la, Biogen; lenalidomide; mesalazine ; GED-0001; AJG-501; metenkefalin acetate with tridecactide acetat, mycophenolate mofetil; naltrexone;
  • natalizumab nitazoxanide; olsalazine; oprelvekin; propionyl-L-carnitine; recombinant interferon beta- la, Serono; remestemcel-L; rifaximin; rituximab; ropivacaine;
  • rosiglitazone rosiglitazone; sargramostim; secukinumab; SPD-480; tacrolimus; tamibarotene;
  • INN- 108 INN- 108; IR-777; SGM-1019; peg-ilodecakin; PF-06480605; PF-06651600; SER-287;
  • filgotinib foralumab; GED-0507-34-Levo; givinostat; GLPG-0974; GLPG-1205;
  • iberogast N (ulcerative colitis), Bayer; BAY98-7410; INV-103; JNJ-40346527; K(D)PT; KAG-308; KHK-4083; KRP-203; larazotide acetate; CB-01-05-MMX; LY-3074828; mesalamine with N-acetylcysteine ; midismase; molgramostim follow on biologic with fosfomycin with carbapenem (intraintestinal, Crohn's disease), Reponex; multipotent adult progenitor cell therapy (ischemia/cerebral palsy), Athersys/ Healios; NN-8828; olokizumab; OvaSave; P-28-GST; PDA-002; PF-4236921; PF-547659; prednisolone; PUR-0110; QBECO; RBX-2660; repurposed naltrexone (low dose,
  • 5 -Lipoxygenase inhibitors such as zileuton, etalocibm FPL-64170, E-3040, and BU-4601A
  • Acetylcholinesterase inhibitors such as BL-7040
  • ACTH receptor agonists such as metenkefalin acetate with tridecactide acetate, and FAR-404
  • Activin receptor antagonists such as follistatin
  • Acyltransferase inhibitors such as AZD-0585
  • Adrenocorticotrophic hormone ligands such as metenkefalin acetate with tridecactide acetate, and FAR-404
  • AKT1 gene inhibitors such as vidofludimus
  • Alkaline phosphatase modulators such as
  • alkaline phosphatase oral, ulcerative colitis
  • AM-Pharma Alkaline phosphatase stimulators such as bovine alkaline phosphatase
  • Androgen receptor agonists such as PB-005
  • Apolipoprotein C3 antagonists such as AZD-0585;
  • Bactericidal permeability protein stimulators such as opebacan; Beta adrenoceptor antagonists, such as NM-001; Beta-glucuronidase inhibitors, such as KD-018; B- lymphocyte antigen CD20 inhibitors, such as ocrelizumab, rituximab; Bradykinin receptor modulators, such as givinostat; Calcineurin inhibitors, such as tacrolimus, ciclosporin; Calcium channel inhibitors, such as clotrimazole; Cannabinoid CBl receptor modulators, such as GWP42003-P, cannabidiol; Cannabinoid CB2 receptor modulators, such as GWP42003-P, cannabidiol; Cannabinoid receptor antagonists, such as fingolimod; Cannabinoid receptor modulators, such as GWP42003-P, cannabidiol; Cathepsin S inhibitors, such as VBY-129, VBY-
  • ELND-004 CD89 agonists, such as HF-1020; Cell adhesion molecule inhibitors, such as natalizumab, alicaforsen (intravenous), ASP- 2002, ISIS-2302; Chemokine CXC ligand inhibitors, such as CXCRl/2 ligands mAb (immunology), Eli Lilly; CHST15 gene inhibitors, such as STNM-01; Collagen modulators, such as adipose-derived stem cell therapy (Celution System), Cytori, DCCT-10; CSF-1 agonists, such as sargramostim, molgramostim follow on biologic with fosfomycin with carbapenem (intraintestinal, Crohn's disease), Reponex; CSF-1 antagonists, such as JNJ-40346527; CXC 10 chemokine ligand inhibitors, such as 946414-98-8, BMS-936557; CXCR2 chemokine antagonists, such as elub
  • Cytotoxic T-lymphocyte protein-4 stimulators such as abatacept; Dihydroceramide delta 4 desaturase inhibitors, such as ABC-294640; Dihydroorotate dehydrogenase inhibitors, such as vidofludimus ; DNA polymerase inhibitors, such as valganciclovir; EGFR family tyrosine kinase receptor modulators, such as neuregulin 4 (Crohn's
  • Eosinophil peroxidase inhibitors such as AWEPOPD-01, AWEPO-003
  • Eotaxin ligand inhibitors such as bertilimumab
  • EP4 prostanoid receptor agonists such as KAG-308
  • Epidermal growth factor agonists such as heparin-EGF-like factor, Scios Nova
  • Epidermal growth factor ligands such as Hebervis
  • Estrogen receptor beta agonists such as prinaberel
  • Factor XIII agonists such as catridecacog
  • FGF-10 ligands such as repifermin
  • FGF2 receptor agonists such as F2A
  • Fractalkine ligand inhibitors such as E-6011
  • Free fatty acid receptor 2 antagonists such as GLPG-0974
  • GATA 3 transcription factor inhibitors such as SB-012
  • IL-6 antagonists such as tocilizumab
  • IL6 gene inhibitors such as YSIL6-T-PS
  • IL-6 receptor modulators such as tocilizumab
  • IL-7 antagonists such as interleukin-7 receptor modulators (ulcerative colitis / T-cell acute lymphoblastic leukaemia), Effimune
  • IL-8 antagonists such as elubrixin, clotrimazole
  • Immunoglobulin Gl agonists such as HF-1020
  • Immunoglobulin G2 modulators such as PF-547659
  • Inosine monophosphate dehydrogenase inhibitors such as mycophenolate mofetil
  • Insulin sensitizers such as elafibranor, rosiglitazone, HE-3286, EGS-21; Integrin alpha- 4/beta-l antagonists, such as natalizumab, TRK-170, firategrast; Integrin alpha-4/beta-7 antagonists, such as etrolizumab, vedolizumab, abrilumab, carotegast methyl, TRK-170, firategrast; Integrin alpha-E antagonists, such as etrolizumab; Integrin antagonists, such as vatelizumab, ASP- 2002; Integrin beta-7 antagonists, such as etrolizumab; Interferon beta ligands, such as interferon beta-la, recombinant interferon beta-la, Serono;
  • Interleukin 17E ligand inhibitors such as anti-IL-17BR humanized antibody (lung fibrosis/asthma/ulcerative colitis), Medical Research Council Technology; Interleukin ligand inhibitors, such as HE-3286; Interleukin receptor 17A antagonists, such as brodalumab; Interleukin receptor 17B antagonists, such as anti-IL-17BR humanized antibody (lung fibrosis/asthma/ulcerative colitis), Medical Research Council
  • Interleukin- 1 beta ligands such as K(D)PT, PUR-0110, HMPL-004;
  • Interleukin- 1 beta ligand modulators such as PUR-0110, HMPL-004; Interleukin-6 ligand inhibitors, such as PF-4236921; JAK tyrosine kinase inhibitors, such as tofacitinib, peficitinib; Jakl tyrosine kinase inhibitors, such as ABT-494, tofacitinib, filgotinib, peficitinib, GLPG-0555, solcitinib; JAK2 gene inhibitors, such as vidofludimus; Jak3 tyrosine kinase inhibitors, such as tofacitinib, peficitinib; Jun N terminal kinase inhibitors, such as semapimod; LanC like protein 2 modulators, such as BT-11; Leukotriene BLT receptor antagonists, such as ONO-4057, etalocib, SC-53228, SC-52798; Lip
  • Oxidoreductase inhibitors such as olsalazine; P2X7 purinoceptor agonists, such as givinostat; p38 MAP kinase inhibitors, such as RDP-58, doramapimod, semapimod, RWJ-68354; PARP inhibitors, such as EB-47, INO-1003; PDE 4 inhibitors, such as apremilast, tetomilast, CC-1088; PDGF receptor agonists, such as oprelvekin, YM-294; Phagocytosis stimulating peptide modulators, such as 99mTc-RP-128; Phospho MurNAc pentapeptide transferase inhibitors, such as SQ-641; Phospholipase A2 inhibitors, such as varespladib methyl; Platelet activating factor receptor antagonists, such as dersalazine sodium; Potassium channel inhibitors, such as clotrimazo
  • Retinoic acid receptor alpha agonists such as tamibarotene; Retinoic acid receptor beta agonists, such as tamibarotene; Retinoid receptor agonists, such as tamibarotene; RNA polymerase inhibitors, such as rifaximin; SMAD-7 inhibitors, such as mongersen (GED- 0301); Sodium channel inhibitors, such as ropivacaine; Somatostatin receptor agonists, such as vapreotide; Sphingosine 1 phosphate phosphatase 1 stimulators, such as APD- 334; Sphingosine 1 phosphate phosphatase modulators, such as SIP modulators (oral, multiple sclerosis/ ulcerative colitis/rheumatoid arthritis), Akaal Pharma; Sphingosine kinase 1 inhibitors, such as ABC-294640; Sphingosine kinase 2 inhibitors, such as ABC- 294640; Sphingos
  • oligonucleotide (Crohns disease/colitis), AID; Stem cell antigen-1 inhibitors, such as Ampion, DMI-9523; Superoxide dismutase modulators, such as midismase, LT-0011; Superoxide dismutase stimulators, such as superoxide dismutase; T cell surface glycoprotein CD28 inhibitors, such as abatacept; TGF beta 1 ligand inhibitors, such as mongersen, GED-0301; Thymulin agonists, such as Syn-1002; TLR-2 antagonists, such as VB-201; TLR-4 antagonists, such as JKB-122, VB-201; TLR-9 agonists, such as BL- 7040, cobitolimod; TNF alpha ligand inhibitors, such as adalimumab, certolizumab pegol, infliximab biosimilar, infliximab, golimumab, ISIS-104838, CSA-13,
  • 14-3-3 protein eta inhibitors 14-3-3 protein eta inhibitors, 5-Lipoxygenase inhibitors, Abl tyrosine kinase inhibitors, ACTH receptor agonists, Adenosine A3 receptor agonists, Adenosine deaminase inhibitors, ADP ribosyl cyclase- 1 modulators, ADP ribosylation factor 6 inhibitors,
  • Adrenocorticotrophic hormone ligands Adrenocorticotrophic hormone ligands, Aggrecanase-2 inhibitors, Albumin modulators, API transcription factor inhibitors, Basigin inhibitors, Bcr protein inhibitors, B- lymphocyte antigen CD 19 inhibitors, B -lymphocyte antigen CD20 inhibitors, B- lymphocyte antigen CD20 modulators, B-lymphocyte stimulator ligand inhibitors, Bradykinin receptor modulators, BRAF gene inhibitors, Branched amino acid aminotransferase 1 inhibitors, Bromodomain containing protein inhibitors, Btk tyrosine kinase inhibitors, Cadherin-11 antagonists, Calcineurin inhibitors, Calcium channel inhibitors, Carbonic anhydrase inhibitors, Cathepsin K inhibitors, Cathepsin S inhibitors, CCR1 chemokine antagonists, CCR2 chemokine antagonists, CCR3 gene modulators, CCR5 chemokine antagonists, CD 126 antagonists, CD
  • Metalloprotease-9 inhibitors Midkine ligand inhibitors, Mitochondrial 10 kDa heat shock protein stimulators, mTOR complex 1 inhibitors, mTOR inhibitors, NAD ADP ribosyltransferase stimulators, NAMPT gene inhibitors, NF kappa B inhibitor stimulators, NFAT gene inhibitors, NFE2L2 gene stimulators, Nicotinic acetylcholine receptor antagonists, NK cell receptor modulators, NKG2 A B activating NK receptor antagonists, NKG2 D activating NK receptor antagonists, Nuclear erythroid 2-related factor 2 stimulators, Nuclear factor kappa B inhibitors, Nuclear factor kappa B modulators, Nuclear factor kappa B pl05 inhibitors, Opioid growth factor receptor agonists, Opioid receptor delta antagonists, Osteoclast differentiation factor antagonists, Osteoclast differentiation factor ligand inhibitors, Oxidoreductase inhibitors, P2X7 purinocept
  • Transcription factor RelB inhibitors Transferrin modulators, Tumor necrosis factor 13C receptor antagonists, Tumor necrosis factor 15 ligand inhibitors, Tumor necrosis factor ligand 13 inhibitors, Tumor necrosis factor ligand inhibitors, Type I IL- 1 receptor antagonists, Type I TNF receptor antagonists, Type II TNF receptor modulators, Unspecified GPCR agonists, VEGF receptor antagonists, VEGF-2 receptor antagonists, VEGF-2 receptor modulators, VEGF-B ligand inhibitors, X-linked inhibitor of apoptosis protein inhibitors, Zap70 tyrosine kinase inhibitors, 99mTc labelled annexin V-128, abatacept, abatacept biosimilar, ABBV-257, ABT-122, ABT-494, acalabrutinib, aceclofenac, actarit, MS-392, adalimumab, adalimumab biosimilar, a
  • clazakizumab CNTO-6785, corticotropin, Mallinckrodt, CR-6086, CreaVax-RA, CWG- 92, CWG-940, Cx-611, DE-098, deflazacort, Rheumavax, denosumab, diacerein, diclofenac, E-6011, eicosapentaenoic acid monoglycerides, etanercept, etanercept biosimilar, etanercept follow-on biologic, etodolac, etoricoxib, filgotinib, fosdagrocorat, gerilimzumab, ginsenoside C-K, givinostat, goat polyclonal antibodies, golimumab, GS- 5745, GS-9876, GSK-3196165, HM-71224, HMPL-523, hyaluronate sodium, IB-RA (injectable, rhe
  • eta inhibitors such as anti-AGX-020 mAbs (rheumatoid arthritis), Augurex; 5 -Lipoxygenase inhibitors, such as tenoxicam, darbufelone, tebufelone, licofelone, ZD-2138, etalocib, tenidap, tepoxalin, flobufen, SKF-86002, PGV-20229, L-708780, WY-28342, T-0757, T-0799, ZM-216800, L-699333, BU- 4601A, SKF-104351, CI-986; Abl tyrosine kinase inhibitors, such as imatinib; ACTH receptor agonists, such as F
  • Adrenocorticotrophic hormone ligands such as corticotropin, Mallinckrodt, FAR-404, metenkefalin acetate with tridecactide acetate; Aggrecanase-2 inhibitors, such as GIBH- R-001-2; Albumin modulators, such as ALX-0061, ONS-1210; API transcription factor inhibitors, such as T-5224, tarenflurbil, SP-10030; Basigin inhibitors, such as ERG-240; Bcr protein inhibitors, such as imatinib; B-lymphocyte antigen CD19 inhibitors, such as XmAb-5871, MDX-1342; B-lymphocyte antigen CD20 inhibitors, such as ocrelizumab, ofatumumab, rituximab, rituximab biosimilar, veltuzumab, rituximab follow-on biologic, ocaratuzumab, BLX-301, IDEC-102
  • CD39/CD73 (rheumatoid arthritis), Arthrogen; CD79b modulators, such as MGD-010; CD80 antagonists, such as RhuDex, XENP-9523, ASP-2408, abatacept biobetter; CD86 antagonists, such as ES-210, abatacept biosuperior, ASP-2408, XENP-9523; CD95 antagonists, such as DE-098, CS-9507; Cell adhesion molecule inhibitors, such as natalizumab, alicaforsen, NPC-17923, TK-280, PD-144795; Choline kinase inhibitors, such as choline kinase inhibitors (rheumatoid arthritis), UC San Diego; Clusterin stimulators, such as alemtuzumab; Complement C5 factor inhibitors, such as eculizumab, antisense oligonucleotides (rheumatoid arthritis), Leiden University Medical Center
  • Cyclin-dependent kinase-2 inhibitors such as seliciclib, BP- 14
  • Cyclin-dependent kinase-4 inhibitors such as CDK- 4/6 inhibitor (rheumatoid arthritis), Teijin
  • Cyclin-dependent kinase-5 inhibitors such as BP-14
  • Cyclin-dependent kinase-6 inhibitors such as CDK-4/6 inhibitor (rheumatoid arthritis), Teijin
  • Cyclin-dependent kinase-7 inhibitors such as BP-14, seliciclib
  • Cyclin- dependent kinase-9 inhibitors such as BP-14, seliciclib
  • Cyclooxygenase 2 inhibitors such as celecoxib, etoricoxib, polmacoxib, laflunimus, etodolac, meloxicam, IB-RA (injectable, rheumatoid arthritis),
  • IB-RA injectable, rheumatoid arthritis
  • IL-15 antagonists such as AMG-714, BNZ-132-2
  • IL-17 antagonists such as ixekizumab, secukinumab, KD-025
  • IL-17 receptor modulators such as CNTO- 6785
  • IL-2 agonists such as interleukin-2 follow-on biologic
  • IL-2 antagonists such as IB-RA (injectable, rheumatoid arthritis), Innobioscience, IB-RA (oral, rheumatoid arthritis), Innobioscience, BNZ-132-2
  • IL-21 antagonists such as NN-8828, BNZ-132-2
  • IL-23 antagonists such as ustekinumab, briakinumab
  • IL-3 antagonists such as anti-IL-3 mAbs (rheumatoid arthritis), University of Regensburg
  • IL-4 agonists such as SER-130- AMI
  • IL-6 antagonists such as o
  • Immunoglobulin Gl agonists such as canakinumab, infliximab biobetter, infliximab biosimilar, BX-2922, STI-002, HF-1020; Immunoglobulin Gl antagonists, such as YHB- 1411-2; Immunoglobulin Gl modulators, such as CFZ-533, lenzilumab;
  • Immunoglobulin G2 antagonists such as denosumab; Immunoglobulin G2 modulators, such as PF-547659; Immunoglobulin gamma Fc receptor II modulators, such as MGD- 010; Immunoglobulin gamma Fc receptor IIB antagonists, such as XmAb-5871;
  • Immunoglobulin kappa modulators such as lenzilumab; Immunoglobulin M antagonists, such as IB-RA (injectable, rheumatoid arthritis), Innobioscience, IB-RA (oral, rheumatoid arthritis), Innobioscience; Inducible nitric oxide synthase inhibitors, such as SKLB-023; Inosine monophosphate dehydrogenase inhibitors, such as mycophenolate mofetil; Insulin sensitizers, such as rosiglitazone, THR-0921, HE-3286, BLX-1002; Integrin alpha- 1 /beta- 1 antagonists, such as SAN-300; Integrin alpha-4/beta- 1 antagonists, such as natalizumab; Integrin antagonists, such as PEG-HM-3, CY-9652; Interferon beta ligands, such as recombinant interferon beta-la, TA-3
  • Interleukin ligands such as IBPB-007-IL; Interleukin receptor 17A antagonists, such as brodalumab; Interleukin- 1 beta ligand inhibitors, such as canakinumab, rilonacept, T- 5224, gevokizumab, BLX-1002, LY-2189102, PMI-001, K-832, CDP-484; Interleukin- 10 ligands, such as PF-06687234; Interleukin-2 ligands, such as denileukin diftitox, recombinant interleukin-2, interleukin-2 follow-on biologic, recombinant human interleukin-2, interleukin-2 (injectable); Interleukin-4 ligands, such as Tetravil;
  • Interleukin-6 ligand inhibitors such as gerilimzumab, PF-4236921; Itk tyrosine kinase inhibitors, such as ARN-4079; JAK tyrosine kinase inhibitors, such as tofacitinib, SHR- 0302, cerdulatinib, peficitinib, deuterated tofacitinib analog, SD-900, CVXL-0074; Jakl tyrosine kinase inhibitors, such as ABT-494, baricitinib, ruxolitinib, filgotinib, tofacitinib, itacitinib, peficitinib, NIP-585, CS-944X, YJC-50018, GLPG-0555, MRK- 12; Jak2 tyrosine kinase inhibitors, such as baricitinib, ruxolitinib, CT-1578; J
  • Metalloprotease-2 inhibitors such as ERG-240; Metalloprotease-9 inhibitors, such as GS-5745, ERG-240; Midkine ligand inhibitors, such as CAB-102; Mitochondrial 10 kDa heat shock protein stimulators, such as INV-103; mTOR complex 1 inhibitors, such as everolimus; mTOR inhibitors, such as everolimus, temsirolimus; NAD ADP
  • ribosyltransferase stimulators such as denileukin diftitox; NAMPT gene inhibitors, such as ART-D01; NF kappa B inhibitor stimulators, such as denosumab; NFAT gene inhibitors, such as T-5224; NFE2L2 gene stimulators, such as bardoxolone methyl; Nicotinic acetylcholine receptor antagonists, such as RPI-78, RPI-MN; NK cell receptor modulators, such as masitinib; NKG2 A B activating NK receptor antagonists, such as monalizumab; NKG2 D activating NK receptor antagonists, such as NNC-0142-002; Nuclear erythroid 2-related factor 2 stimulators, such as dimethyl fumarate; Nuclear factor kappa B inhibitors, such as bardoxolone methyl, IB-RA (injectable, rheumatoid arthritis), Innobioscience, dehydroxymethylepoxyquinomicin,
  • Osteoclast differentiation factor antagonists such as denosumab, cyclic peptidomimetics (rheumatoid arthritis/osteoporosis), University of Michigan; Osteoclast differentiation factor ligand inhibitors, such as denosumab; Oxidoreductase inhibitors, such as etodolac, imidazole salicylate; P2X7 purinoceptor agonists, such as givinostat; p38 MAP kinase alpha inhibitors, such as VX-745, BMS-582949 prodrugs, BMS-751324; p38 MAP kinase inhibitors, such as BCT-197, losmapimod, ARRY-797; PDE 4 inhibitors, such as apremilast; PDE 5 inhibitors, such as PDE5 inhibitors (rheumatoid arthritis), University of Rochester; PDGF receptor agonists, such as oprelvekin; PDGF receptor antagonists,
  • rheumatoid arthritis/asthma/ Alzheimer' s disease/cancer University of California, Davis, AK-106, varespladib methyl, Ro-31-4493, BM-162353, Ro-23-9358, YM-26734; Platelet activating factor receptor antagonists, such as piperidone hydrochloridum; PPAR gamma agonists, such as rosiglitazone, THR-0921, rosiglitazone XR, etalocib;
  • Programmed cell death protein 1 modulators such as INSIX RA; Prostaglandin D synthase stimulators, such as HF-0220; Protein arginine deiminase inhibitors, such as PAD inhibitors (rheumatoid arthritis), Leiden University Medical Center/LURIS; Protein tyrosine kinase inhibitors, such as leflunomide; PurH purine biosynthesis protein inhibitors, such as mycophenolate mofetil; Rho associated protein kinase 2 inhibitors, such as KD-025; Seprase inhibitors, such as anti-fibroblast-activation protein (FAP) antibody radiotracers (rheumatoid arthritis), Hoffmann-La Roche/ Radboud University; Signal transducer CD24 modulators, such as CD24-IgFc; Signal transduction inhibitors, such as imatinib; Sodium glucose transporter-2 inhibitors, such as THR-0921;
  • Sphingosine 1 phosphate phosphatase modulators such as SIP modulators (oral, multiple sclerosis/ ulcerative colitis/rheumatoid arthritis), Akaal Pharma; STAT3 gene inhibitors, such as bardoxolone methyl, vidofludimus; Superoxide dismutase stimulators, such as imisopasem manganese; SYK family tyrosine kinase inhibitors, such as MK- 8457; Syk tyrosine kinase inhibitors, such as fostamatinib, entospletinib, KDDF-201110- 06, HMPL-523, cerdulatinib, AB-8779, GS-9876, PRT-2607, CVXL-0074, CG-
  • Syndecan-1 inhibitors such as indatuximab ravtansine
  • T cell receptor antagonists such as TCR inhibiting SCHOOL peptides (systemic/topical, rheumatoid arthritis/dermatitis/scleroderma), SignaBlok, CII modified peptide
  • T cell receptor modulators such as ARG-301
  • T cell surface glycoprotein CD28 inhibitors such as abatacept, belatacept, abatacept biosimilar, RhuDex, BMS-188667
  • T cell surface glycoprotein CD28 stimulators such as TAB-08
  • TAK1 binding protein modulators such as epigallocatechin 3-gallate
  • Talin modulators such as short-form talin regulators (rheumatoid arthritis), KayteeBio
  • T-cell differentiation antigen CD6 inhibitors such as itolizumab
  • T-cell surface glycoprotein CD8 inhibitors such as tregalizumab
  • Tenascin modulators such as Tetravil
  • TGF beta agonists such as tregalizumab
  • Thymulin agonists such as Syn-1002
  • TLR-2 antagonists such as VB-201, P-13
  • TLR-4 antagonists such as VB-201, P-13
  • TLR-9 TLR-9
  • TNFSF11 gene inhibitors such as denosumab; Transcription factor p65 inhibitors, such as REM-1086; Transcription factor RelB inhibitors, such as REM-1086; Transferrin modulators, such as methotrexate, MBP-Y003; Tumor necrosis factor 13C receptor antagonists, such as VAY-736; Tumor necrosis factor 15 ligand inhibitors, such as anti- TL1A antibodies (rheumatoid arthritis/inflammatory bowel disease), NIAMS; Tumor necrosis factor ligand 13 inhibitors, such as atacicept; Tumor necrosis factor ligand inhibitors, such as ABBV-257, etanercept biosimilar, ABT-122; Type I IL-1 receptor antagonists, such as anakinra, anakinra biosimilar, anakinra follow-on biologic, AXXO; Type I TNF receptor antagonists, such as NM-9405; Type II TNF receptor modulators, such as etaner
  • metabolic disorders include, without limitation, diabetes, including type I and type II diabetes, metabolic syndrome, dyslipidemia, obesity, glucose intolerance, hypertension, elevated serum cholesterol, and elevated triglycerides.
  • therapeutic agents used to treat metabolic disorders include,
  • one aspect of the disclosure is a method of treating a metabolic disease comprising administering a compound of the disclosure in combination with one or more compounds useful for the treatment of metabolic diseases to a subject, particularly a human subject, in need thereof.
  • compositions While it is possible for the active ingredients to be administered alone it may be preferable to present them as pharmaceutical formulations (compositions).
  • compositions both for veterinary and for human use, of the invention comprise at least one active ingredient, as above defined, together with one or more acceptable carriers therefor and optionally other therapeutic ingredients.
  • the carrier(s) must be
  • the formulations include those suitable for the foregoing administration routes.
  • the formulations may conveniently be presented in unit dosage form and may be prepared by any of the methods well known in the art of pharmacy. Techniques and formulations generally are found in Remington's Pharmaceutical Sciences (Mack Publishing Co., Easton, PA). Such methods include the step of bringing into association the active ingredient with inactive ingredients (e.g., a carrier, pharmaceutical excipient, etc.) which constitutes one or more accessory ingredients.
  • inactive ingredients e.g., a carrier, pharmaceutical excipient, etc.
  • the formulations are prepared by uniformly and intimately bringing into association the active ingredient with liquid carriers or finely divided solid carriers or both, and then, if necessary, shaping the product.
  • formulations suitable for oral administration are presented as discrete units such as capsules, cachets or tablets each containing a predetermined amount of the active ingredient.
  • the pharmaceutical formulations include one or more compounds of the invention together with one or more pharmaceutically acceptable carriers or excipients and optionally other therapeutic agents.
  • Pharmaceutical formulations containing the active ingredient may be in any form suitable for the intended method of administration. When used for oral use for example, tablets, troches, lozenges, aqueous or oil suspensions, dispersible powders or granules, emulsions, hard or soft capsules, syrups or elixirs may be prepared.
  • Compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents including sweetening agents, flavoring agents, coloring agents and preserving agents, in order to provide a palatable preparation.
  • Tablets containing the active ingredient in admixture with non-toxic pharmaceutically acceptable excipient which are suitable for manufacture of tablets are acceptable.
  • excipients may be, for example, inert diluents, such as calcium or sodium carbonate, lactose, lactose monohydrate, croscarmellose sodium, povidone, calcium or sodium phosphate; granulating and disintegrating agents, such as maize starch, or alginic acid; binding agents, such as cellulose, microcrystalline cellulose, starch, gelatin or acacia; and lubricating agents, such as magnesium stearate, stearic acid or talc.
  • inert diluents such as calcium or sodium carbonate, lactose, lactose monohydrate, croscarmellose sodium, povidone, calcium or sodium phosphate
  • granulating and disintegrating agents such as maize starch, or alginic acid
  • binding agents such as cellulose, microcrystalline cellulose, starch,
  • Tablets may be uncoated or may be coated by known techniques including microencapsulation to delay disintegration and adsorption in the gastrointestinal tract and thereby provide a sustained action over a longer period.
  • a time delay material such as glyceryl monostearate or glyceryl distearate alone or with a wax may be employed.
  • a dosage form for oral administration to humans contains approximately 1 to 1000 mg of active material formulated with an appropriate and convenient amount of carrier material (e.g., inactive ingredient or excipient material).
  • the carrier material varies from about 5 to about 95% of the total compositions (weight: weight).
  • the pharmaceutical compositions described herein contain about 1 to 800 mg, 1 to 600 mg, 1 to 400 mg, 1 to 200 mg, 1 to 100 mg or 1 to 50 mg of the compound of Formula I, or a pharmaceutically acceptable salt thereof.
  • the pharmaceutical compositions described herein contain not more than about 400 mg of the compound of Formula I.
  • the pharmaceutical compositions described herein contain about 100 mg of the compound of Formula I, or a pharmaceutically acceptable salt thereof.
  • formulations disclosed herein may include other agents conventional in the art having regard to the type of formulation in question, for example those suitable for oral administration may include flavoring agents.
  • compositions comprising at least one active ingredient as above defined together with a veterinary carrier are further provided.
  • Veterinary carriers are materials useful for the purpose of administering the composition and may be solid, liquid or gaseous materials which are otherwise inert or acceptable in the veterinary art and are compatible with the active ingredient. These veterinary compositions may be administered orally, parenterally or by any other desired route.
  • Effective dose of active ingredient depends at least on the nature of the condition being treated, toxicity, whether the compound is being used prophylactically (lower doses), the method of delivery, and the pharmaceutical formulation, and will be determined by the clinician using conventional dose escalation studies.
  • One or more compounds of Formula I are administered by any route appropriate to the condition to be treated. Suitable routes include oral, rectal, nasal, topical (including buccal and sublingual), vaginal and parenteral (including
  • the pharmaceutical compositions described herein are oral dosage forms.
  • the pharmaceutical compositions described herein are oral solid dosage forms.
  • Hard gelatin capsules containing the following ingredients are prepared:
  • the components are blended and compressed to form tablets.
  • a dry powder inhaler formulation is prepared containing the following components:
  • the active ingredient is mixed with the lactose and the mixture is added to a dry powder inhaling appliance.
  • Tablets each containing 30 mg of active ingredient, are prepared as follows:
  • the active ingredient, starch and cellulose are passed through a No. 20 mesh U.S. sieve and mixed thoroughly.
  • the solution of polyvinylpyrrolidone is mixed with the resultant powders, which are then passed through a 16 mesh U.S. sieve.
  • the granules so produced are dried at 50 °C to 60 °C and passed through a 16 mesh U.S. sieve.
  • the sodium carboxymethyl starch, magnesium stearate and talc, previously passed through a No. 30 mesh U.S. sieve, are then added to the granules which, after mixing, are compressed on a tablet machine to yield tablets each weighing 120 mg.
  • Suppositories each containing 25 mg of active ingredient are made as follows:
  • the active ingredient is passed through a No. 60 mesh U.S. sieve and suspended in the saturated fatty acid glycerides previously melted using the minimum heat necessary. The mixture is then poured into a suppository mold of nominal 2.0 g capacity and allowed to cool.
  • Suspensions each containing 50 mg of active ingredient per 5.0 mL dose are made as follows:
  • a subcutaneous formulation may be prepared as follows:
  • An injectable preparation is prepared having the following composition
  • a topical preparation is prepared having the following composition:
  • Sustained release formulations of this disclosure may be prepared as follows:
  • aqueous solutions of strong bases are solutions of alkali metal hydroxides, such as sodium or potassium hydroxide, preferably sodium hydroxide, in water (optionally containing up to 25% of water-miscible solvents such as lower alcohols).
  • the resulting tablets may be coated with an optional film-forming agent, for
  • the film forming agent will typically be present in an amount ranging from between 2% and 4% of the tablet weight.
  • Suitable film- forming agents are well known to the art and include hydroxypropyl methylcellulose, cationic methacrylate copolymers (dimethylaminoethyl methacrylate/ methyl-butyl methacrylate copolymers - Eudragit ® E - Rohm. Pharma) and the like. These film-forming agents may optionally contain colorants, plasticizers and other supplemental ingredients.
  • the compressed tablets preferably have a hardness sufficient to withstand 8 Kp compression.
  • the tablet size will depend primarily upon the amount of compound in the tablet.
  • the tablets will include from 300 to 1100 mg of compound free base.
  • the tablets will include amounts of compound free base ranging from 400-600 mg, 650-850 mg and 900-1100 mg.
  • the time during which the compound containing powder is wet mixed is controlled.
  • the total powder mix time i.e. the time during which the powder is exposed to sodium hydroxide solution, will range from 1 to 10 minutes and preferably from 2 to 5 minutes.
  • the particles are removed from the granulator and placed in a fluid bed dryer for drying at about 60°C.
  • the components are blended and compressed to form tablets.
  • MeMgX Methylmagnesium halide (Grignard reagent), where X is Fluoro, Chloro, Bromo or lodo
  • Pd-PEPPSITM -IPent [l,3-bis(2,6-di-3-pentylphenyl)imidazol-2- ylidene](3-chloropyridyl)palladium(II) dichloride
  • the compounds of formula 1.5 may be accessed according to the method outlined in Scheme 1.
  • 1-aminopyrrole 1.1 maybe be condensed with a suitable coupling partner to produce substituted pyrrolo[l,2-b]pyridazine 1.2 using a suitable catalyst (e.g, HC1, etc.) and suitable solvent (e.g., EtOH, etc.).
  • a suitable catalyst e.g, HC1, etc.
  • suitable solvent e.g., EtOH, etc.
  • Halogenation at the position shown using a known halogenating reagent can form the intermediate 1.3, wherein X is chloro, bromo, or iodo and where intermediate 1.3 can be further substituted either via C-H activation or electrophilic aromatic substitution with a suitable reagent (e.g., selectfluor, etc.) to produce intermediate 1.4.
  • a suitable reagent e.g., selectfluor, etc.
  • Halogen metal exchange of -X to -M can then be achieved using a suitable reagent (e.g, n-BuLi, etc.) or transition metal coupling using a palladium catalyst and metal source (e.g., B 2 Pin 2 , Me 6 Sn 2 , etc.) to give intermediate 1.5, wherein M is a metal, such as tin or boron.
  • a substituted 1-amino pyrrole 1.6 can be converted to the pyrrolo[l,2-b]pyridazine heterocycle 1.7 by the condensation described above.
  • Heterocycle 1.7 can be converted via halogenation to an intermediate of the type 1.4.
  • Compounds of Formula (I) may be assembled by first reacting an amine with intermediate 2.1 at C-4 to give intermediate 2.2. Following conversion to the acid 2.3 using a suitable reagent (e.g, LiOH, Lil and pyridine, etc.) a second amine can be introduced to give amide 2.4 using standard amide bond forming conditions (e.g., DIPEA with HATU, etc.). Coupling of the metal-containing species (1.5) with intermediate 2.4 using a suitable catalyst, such as a palladium catalyst, can afford a compound of Formula (I).
  • a suitable reagent e.g, LiOH, Lil and pyridine, etc.
  • a second amine can be introduced to give amide 2.4 using standard amide bond forming conditions (e.g., DIPEA with HATU, etc.).
  • a suitable catalyst such as a palladium catalyst
  • compounds of formula (I) may be assembled by first addition of amine to carboxylic acid 3.1 using standard amide bond formation (e.g., DIPEA with HATU, etc.) to give amide 3.2. Addition of an amine to the C-4 position of 3.2 may produce intermediate 2.4 which can in turn be coupled with intermediate 1.5 using a suitable catalyst, such as a palladium catalyst, to yield a compound of Formula (I).
  • amide bond formation e.g., DIPEA with HATU, etc.
  • a suitable catalyst such as a palladium catalyst
  • a compound of Formula (I) can also be prepared as shown in Scheme 4 beginning with the coupling of intermediate 2.2 and heterocycle 1.5 using a suitable catalyst, such as a palladium catalyst, to give compound 4.1.
  • Conversion of the ester 4.1 to carboxylic acid 4.2 may be accomplished using known conditions (e.g. LiOH, Lil with pyridine, etc.).
  • a compound of Formula (I) can be accessed by addition of an amine to intermediate 4.2 using standard amide bond forming conditions (e.g. HATU with DIPEA, etc.).
  • an amine may be added to C-4 of compound 3.1 using base (e.g. NaH, LiHMDS, etc.) to directly yield intermediate 2.3. This can be converted to compound (I) in the same manner as illustrated in Scheme 2.
  • base e.g. NaH, LiHMDS, etc.
  • the compound may be reacted with an appropriate reagent (e.g. hexamethylditin, etc.) to afford compound 6.1.
  • an appropriate reagent e.g. hexamethylditin, etc.
  • This can be coupled with halogenated heterocycle 1.4 using an appropriate catalyst (e.g. palladium catalyst, etc.) to yield compound (I).
  • an appropriate catalyst e.g. palladium catalyst, etc.
  • compound 2.1 may be initially coupled with intermediate 1.5 using a suitable catalyst, such as a palladium catalyst, to give monohalogenated product 7.1.
  • a suitable catalyst such as a palladium catalyst
  • Addition of an amine can produce intermediate ester 7.2 after which conversion to the carboxylic acid can yield intermediate 7.3.
  • Addition of an amide using amide bond forming conditions e.g., DIPEA with HATU, etc. may produce compound (I).
  • ester 7.1 may be converted to the corresponding carboxylic acid 8.1 via known hydrolysis conditions (e.g. LiOH, Lil with pyridine, etc.).
  • Amide bond formation using standard conditions (e.g., DIPEA with HATU, etc.) to produce intermediate 8.2 can then be followed by introduction of an amine into the C-4 position to give compound (I).
  • Scheme 9 :
  • R groups are possible following their incorporation.
  • a specific illustrative example of an alteration to the R 1 group is shown in Scheme 10 wherein the secondary amine 10.1 is reacted to form a methyl sulfonamide 10.2.
  • Other functional groups may also be present in the R 1 and can be manipulated. These groups and manipulations can include, but are not limited to, oxidation, elimination or displacement using suitable reagents known to those skilled in the art.
  • the order of synthetic manipulations may be carried out in a fashion that is consistent with the methods outlined in Schemes 1-9 and should not be limited to the final step of compound preparation.
  • Variations of the R 2 group may also be performed following formation of the amide.
  • An illustrative example is shown in Scheme 11, though the groups present or synthetic manipulations performed are not limited to those shown in Scheme 11, wherein a methyl ester 11.1 is reacted with MeMgX or MeLi to yield the shown tertiary alcohol 11.2.
  • the order of synthetic manipulations may be carried out in a fashion that is consistent with the methods outlined in Schemes 1-9 and should not be limited to the final step of compound preparation.
  • a microwave vial was charged with 7-bromopyrrolo[l,2-b]pyridazine-3-carbonitrile (I- 1F, 416.5 mg, 1.9 mmol), bis(pinacolato)diboron (762.1 mg, 3.0 mmol), potassium acetate (552.3 mg, 5.6 mmol), and bis(triphenylphosphine)palladium(II) dichloride (65.8 mg, 0.094 mmol).
  • Dioxane (8.0 mL) and DMF (4.0 mL) were added, and the reaction mixture was degassed with bubbling argon for 2 minutes.
  • the vial was sealed and the reaction was heated at 120 °C in a microwave reactor for 60 minutes.
  • Methyl 4,6-dibromonicotinate (1-3) Methyl 4,6-dichloronicotinate (5.0 g, 24.3 mmol) was suspended in hydrogen bromide (33% in Acetic Acid, 24 mL). The reaction vessel was sealed and heated to 60 °C for 4 hours. The reaction was cooled to room temperature and diluted with 3 ⁇ 40. The resulting solids were filtered, washed with 3 ⁇ 40. The solids were then suspended in 3 ⁇ 40 and basified with aqueous sodium hydroxide. The resulting aqueous solution was extracted with EtOAc (3 times). The resulting organic layers were combined, dried over Na 2 S0 4 , and concentrated to provide methyl 4,6-dibromonicotinate.
  • Methyl 6-bromo-4-(isopropylamino)nicotinate (1-4): To a solution of methyl 4,6- dibromonicotinate (7.16 g, 24.3 mmol) in acetonitrile (125 mL) and 3 ⁇ 40 (3 mL) was added isopropylamine (15.3 mL, 177 mmol). The reaction vessel was sealed and heated to 80 °C for 2 hours. The resulting solution was cooled to room temperature and concentrated to dryness. The resulting oil was purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide methyl 6-bromo-4-(isopropylamino)nicotinate. ES/MS: 273.569 (M+H + ).
  • 6-bromo-4-chloronicotinic acid 6-bromo-4-chloronicotinic acid.
  • methanol 240 mL
  • lithium hydroxide 2.93 g, 119.77 mmol
  • water 68mL
  • Aqueous hydrochloric acid (1M, 120 mL) was added and volatiles were removed in vacuo.
  • the resulting slurry was filtered and washed with 3 ⁇ 40 to provide 6-bromo-4-chloronicotinic acid.
  • Ethyl 6-chloro-4-(N-(methylsulfonyl)methylsulfonamido)nicotinate To a solution of ethyl 4-amino-6-chloronicotinate (334 mg, 1.67 mmol) and triethylamine (0.7 mL, 5 mmol) in dichloromethane (5 mL), was added methanesulfonyl chloride ( 0.39 mL, 5 mmol) slowly. The mixture was stirred overnight. Diluted with EtOAc (20 mL) and washed with aqueous NaHCC>3, and brine. The organic layer was dried and concentrated. The mixture was purified by silica gel chromatography (eluent: EtOAc/hexanes)to afford desired product.
  • 6-chloro-4-(methylsulfonamido)nicotinic acid (1-6): To a solution of ethyl 6-chloro-4- (N-(methylsulfonyl)methylsulfonamido)nicotinate (60 mg, 0.17 mmol) in THF/ MeOH (1 mL/ 0.5 mL), Lithium hydroxide (20 mg, 0.8 mmol) was added. It was heated to 50 °C for 3 hours. Acidified by HC1 (IN) and extracted with EtOAc. The organic layer was dried and concentrated to give 1-6 which was used without further purification.
  • I-7A 1-7 Methyl (2-(4-nitrophenyl)propan-2-yl)carbamate (I-7B):
  • Tert-butyl (3-acetamidobicyclo[l.l.l]pentan-l-yl)carbamate To a solution of tert- butyl (3-aminobicyclo[l.l.l]pentan-l-yl)carbamate (303 mg, 1.5 mmol) in CH 2 CI 2 (7.5 mL) at 0 °C was added saturated aqueous sodium bicarbonate (15 mL) and acetic anhydride (0.73 mL, 7.7 mmol). The biphasic solution was warmed to room temperature and stirred for 24 hours. The mixture was extracted with CH 2 CI 2 (3 times). The combine organic layers were dried over MgS0 4 and concentrated to dryness. The resulting material was used without further purification.
  • Ethyl 6-chloro-4-(((lS)-3-fluorocyclohexyl)amino)nicotinate Ethyl 6-chloro-4- (((lS,3S)-3-hydroxycyclohexyl)amino)nicotinate (0.13 g, 0.44 mmol) was dissolved in DCM (6 mL) and brought to 0 °C. DAST (0.069 mL, 0.52 mmol) was then added dropwise over 1 minute. After 5 minutes the reaction mixture was quenched by the addition of saturated aqueous NaHCC>3 solution (1 mL, poured into water (5 mL) and extracted with EtOAc (3 x 5mL).
  • l-(oxazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-amine hydrochloride (1-16): l-(oxazol-5- yl)-2-oxabicyclo[2.2.2]octan-4-amine hydrochloride was prepared identically as described for 1-14 substituting tert-butyl ((lr,4r)-4-formylcyclohexyl)carbamate with tert-butyl (l-formyl-2-oxabicyclo[2.2.2]octan-4-yl)carbamate.
  • 5-(5-nitropyridin-2-yl)oxazole To a solution of 2-bromo-5-nitropyridine (125 mg, 0.62 mmol) in DME (2.5 niL) was added XPhos Pd G3 (43 mg, 0.051 mmol), 5-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)oxazole (132 mg, 0.68 mmol) and K 3 PO 4 (0.5M in water, 1.5 mL, 0.77 mmol). The resulting mixture was heated in a microwave reactor at 120 °C for 20 minutes after which it was poured into water (5 mL) and extracted with EtOAc (2 x 15 mL)).
  • 6-(oxazol-5-yl)pyridin-3-amine (1-18): 5-(5-nitropyridin-2-yl)oxazole (178 mg, 0.093 mmol) was dissolved in THF (3 mL) after which saturated aqueous NH 4 C1 solution (1 mL) and iron (312 mg, 5.6 mmol) were added and the resulting mixture heated to reflux for 2 hours. The mixture was then filtered through a pad of celite which was rinsed with MeOH (5 mL), added to water (5 mL), and extracted with EtOAc (2 x 15 mL). The combined organic layers were dried over MgS0 4 , filtered and concentrated to give 1-18 which was used without further purification.
  • 6-(4-methyloxazol-5-yl)pyridin-3-amine (1-19): 4-methyl-5-(5-nitropyridin-2- yl)oxazole (200 mg, 0.098 mmol) was dissolved in THF (3 mL) after which saturated aqueous NH 4 C1 solution (1 mL) and iron (327 mg, 5.8 mmol) were added and the resulting mixture heated to reflux for 2 hours. The mixture was then filtered through a pad of celite which was rinsed with MeOH (5 mL), added to water (5 mL), and extracted with EtOAc (2 x 15 mL). The combined organic layers were dried over MgS0 4 , and concentrated to give 1-19 which was used without further purification.
  • 5-ethoxy-6-(oxazol-5-yl)pyridin-3-amine (1-20): To a solution of 6-bromo-5- ethoxypyridin-3 -amine (100 mg, 0.51 mmol) in DME (2 mL) was added XPhos Pd G3 (33 mg, 0.038 mmol), 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)oxazole (99 mg, 0.51 mmol) and K 3 PO 4 (0.5M in water, 1.2 mL, 0.58 mmol).
  • Benzyl (2-(oxazol-5-yl)pyrimidin-5-yl)carbamate To a solution of benzyl (2- formylpyrimidin-5-yl)carbamate (225 mg, 0.88 mmol) in BnOH (4 mL) was added p- toluenesulfonylmethylisocyanide (171 mg, 0.88 mmol) and the resulting mixture heated at 65 °C for 16 hours. The mixture was poured into water (10 mL) and extracted with 2 x 30mL EtOAc. The combined organic layers were dried over MgS0 4 , filtered and concentrated. The resulting crude residue, still containing a significant amount of
  • 2-(oxazol-5-yl)pyrimidin-5-amine (1-21): To a solution of benzyl (2-(oxazol-5- yl)pyrimidin-5-yl)carbamate (225 mg, 0.076 mmol) in EtOH (10 mL) in a 50 mL round bottom flask was added 10% Pd/C (323 mg, 0.015 mmol). The head space was flushed with 3 ⁇ 4 gas and an 3 ⁇ 4 balloon then applied to the reaction flask. After 13 hours the reaction mixture was filtered through celite, rinsed with EtOH (2 x 15 mL) and the resulting EtOH solution concentrated to dryness to give crude 1-21 which was used without further purification.
  • tert-butyl ((lr,4r)-4-(l,3,4-oxadiazol-2-yl)cyclohexyl)carbamate To a solution of tert-butyl ((lr,4r)-4-(hydrazinecarbonyl)cyclohexyl)carbamate (556 mg, 2.2 mmol) in DMF (10 mL) was added trimethyl orthoformate (1.3 mL, 12 mmol) and BF 3 -OEt 2 (0.01 mL, 0.011 mmol) under argon.
  • reaction mixture was heated to 50 °C for 4 hours after which it was allowed to cool to room temperature, DIPEA (0.23 mL, 1.3 mmol) was added and the mixture allowed to stir for 12 hours. Upon completion the reaction mixture was poured into water (15 mL) and extracted with EtOAc (2 x 30 mL). The combined organic layers were dried over MgS0 4 , filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent:
  • tert-butyl ((lr,4r)-4-(l,3,4-thiadiazol-2-yl)cyclohexyl)carbamate To a solution of tert-butyl ((lr,4r)-4-(2-formylhydrazine-l-carbonyl)cyclohexyl)carbamate (193 mg, 0.68 mmol) in dioxane (5 mL) was added Lawesson's Reagent (301 mg, 0.74 mmol) and the resulting reaction mixture heated to 100 °C for 3 hours. Upon completion, the reaction mixture was poured into water (5 mL) and extracted with EtOAc (2 x 15 mL). The combined organic layers were dried over MgS0 4 , filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent:
  • BocHN-U tert-butyl ((3R,6S)-6-formyltetrahydro-2H-pyran-3-yl)carbamate To a solution of tert-butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate (200 mg, 0.87 mmol) in DCM (5 mL) at -10 °C was added DIPEA (2.3 mL, 13 mmol) as a single portion followed by a solution of pyridine-S0 3 (1:1) complex (2.1 g, 13 mmol) in DMSO (7 mL) dropwise over 2 minutes.
  • Reaction vessel was transferred to a 0 °C bath and stirred for 1.5 hours then allowed to warm to room temperature over 2.5 hours. Reaction mixture was then brought to -10 °C, pyridine-S0 3 (1:1) complex (400 mg, 2.4 mmol) was added as a single portion, and the reaction mixture allowed to warm to room temperature over 2 hours. Upon completion, reaction mixture was poured into water (20 mL) and extracted with EtOAc (2 x 50 mL). The combined organic layers were washed with water (2 x 30 mL), dried over MgS0 4 , filtered, concentrated and the resulting crude aldehyde was carried forward without further purification.
  • tert-butyl ((3R,6S)-6-(oxazol-5-yl)tetrahydro-2H-pyran-3-yl)carbamate 200 mg, 0.87 mmol
  • MeOH MeOH
  • p-toluenesulfonylmethylisocyanide 170 mg, 0.87 mmol
  • the mixture was poured into water (10 mL) and extracted with 2 x 20mL EtOAc.
  • the combined organic layers were dried over MgS0 4 , filtered and concentrated.
  • the resulting crude residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to give the desired product.
  • tert-butyl (4-(2-methyloxazol-5-yl)cyclohex-3-en-l-yl)carbamate To a solution of 4- ((tert-butoxycarbonyl)amino)cyclohex-l-en-l-yl trifluoromethanesulfonate (150 mg, 0.43 mmol) in DME (3 mL) was added XPhos Pd G3 (18 mg, 0.022 mmol), 2-methyl-5- (4,4,5, 5-tetramethyl-l,3,2-dioxaborolan-2-yl)oxazole (109 mg, 0.52 mmol) and K 3 PO 4 (0.5M in water, 1.3 mL, 0.65 mmol).
  • tert-butyl (4-(2-methyloxazol-5-yl)cyclohexyl)carbamate To a solution of tert-butyl (4-(2-methyloxazol-5-yl)cyclohex-3-en-l-yl)carbamate (140 mg, 0.50 mmol) in EtOH (6 mL) in a 50 mL round bottom flask was added 10% Pd/C (107 mg, 0.10 mmol). The head space was flushed with 3 ⁇ 4 gas and an 3 ⁇ 4 balloon then applied to the reaction flask. After 2 hours the reaction mixture was filtered through celite, rinsed with EtOH (2 x 15 mL) and the resulting EtOH solution concentrated to dryness to give the desired product which was used without further purification.
  • Methyl N,N-dibenzyl-0-(tert-butyldimethylsilyl)-L-serinate To a solution of methyl dibenzyl-L-serinate (2.0 g, 10 mmol) in DCM (10 mL) was added TBS-CI (1.7 g, 11 mmol), DMAP (61 mg, 0.50 mmol) and DIPEA (3.5 mL, 20 mmol) and the resulting solution stirred at room temperature for 3 hours. Upon completion, the reaction mixture was poured into water (20 mL) and extracted with DCM (2 x 20mL). The combined organic layers were dried over MgS0 4 , filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to give the desired product.
  • tert-butyl 4-(4-amino-lH-pyrazol-l-yl)-3,3-difluoropyrrolidine-l-carboxylate (1-28): A solution of tert-butyl 3,3-difluoro-4-(4-nitro-lH-pyrazol-l-yl)pyrrolidine-l- carboxylate (I-28C, 165 mg, 0.518 mmol) in EtOH (15 mL) was degassed with argon and vacuum. Added Pd/C (10%, 28 mg, 0.026 mmol) and stirred with a balloon of hydrogen for 2 d. The reaction was filtered over a Celite plug, rinsed with EtOAc and the filtrate was concentrated to give 1-28.
  • tert-butyl (3R,4R)-3-(4-amino-lH-pyrazol-l-yl)-4-fluoropyrrolidine-l-carboxylate was prepared similarly to 1-28, but substituting tert-butyl 3,3-difluoro-4-hydroxypyrrolidine- 1-carboxylate with tert-butyl (3R,4S)-3-fluoro-4-hydroxypyrrolidine- 1-carboxylate in the first step.
  • tert-butyl (3R,4S)-3-(4-amino-lH-pyrazol-l-yl)-4-fluoropyrrolidine-l-carboxylate was prepared similarly to 1-28, but substituting tert-butyl 3,3-difluoro-4-hydroxypyrrolidine- 1-carboxylate with tert-butyl (3S,4S)-3-fluoro-4-hydroxypyrrolidine-l-carboxylate in the first step.
  • tert-butyl (3S,4R)-3-(4-amino-lH-pyrazol-l-yl)-4-fluoropyrrolidine-l-carboxylate was prepared similarly to 1-28, but substituting tert-butyl 3,3-difluoro-4-hydroxypyrrolidine- 1-carboxylate with tert-butyl (3R,4R)-3-fluoro-4-hydroxypyrrolidine-l-carboxylate in the first step.
  • 3-(l-(4-aminophenyl)cyclopropyl)oxazolidin-2-one was prepared similarly to 1-32, but substituting 2-(4-nitrophenyl)propan-2-amine with l-(4-nitrophenyl)cyclopropan-l- amine in the first step.
  • l-(2-(4-aminophenyl)propan-2-yl)pyrrolidin-2-one (1-34): l-(2-(4-aminophenyl)propan-2-yl)pyrrolidin-2-one was prepared similarly to 1-32, but substituting 2-chloroethyl carbonochloridate with 4-chlorobutanoyl chloride in the first step.
  • Methyl 6-chloro-4-((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinate (1-38): To a solution of methyl 4,6-dichloronicotinate (870 mg, 4.22 mmol) and 1- aminobicyclo[2.2.2]octan-4-ol hydrochloride (500 mg, 2.81 mmol) in butyronitrile (12 mL) was added cesium carbonate (1.98 g, 6.08 mmol). The resulting slurry was heated to 120 °C for 24 hours. The mixture was cooled, diluted with EtOAc, and filtered. The solids were washed with EtOAc and the combined filtrates were concentrated and purified by S1O 2 chromotography (eluent: 2-5% MeOH/CI3 ⁇ 4Cl 2 ) to provide the desired product.
  • S1O 2 chromotography eluent: 2-5% MeOH/CI3 ⁇ 4Cl 2

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Abstract

Provided is a compound of Formula (I), wherein the variable groups are defined herein.

Description

PYRROLO[l,2-b]PYRIDAZINE DERIVATIVES
CROSS REFERENCE TO RELATED APPLICATIONS
This application claims priority benefit to U.S. Provisional Application Serial No. 62/460,013, filed on February 16, 2017, the disclosure of which is incorporated by reference in its entirety.
FIELD
The present disclosure relates to novel compounds that are inhibitors of the kinase IRAK4. The disclosure also relates to methods for preparing the compounds and to pharmaceutical compositions comprising such compounds.
BACKGROUND
Interleukin-1 receptor-associated kinase-4 (IRAK4) is a serine-threonine kinase which acts as a mediator in interleukin- 1/Toll-like receptor (IL-l/TLR) signaling cascades. More particularly, IRAK4 is involved in activation of adaptor protein myeloid differentiation primary response gene 88 (MyD88) signaling cascades and is
hypothesized to play a role in inflammation related disorders as well as in oncology and non-alcoholic steatohepatitis (NASH). Signaling through IL-1R/TLR results in the activation of MyD88 which recruits IRAK4 and IRAKI to form a signaling complex. This complex then interacts with a series of kinases, adaptor proteins, and ligases, ultimately resulting in the activation of nuclear factor kappa- light-chain-enhancer of activated B cells (NF-κΒ) and activator protein- 1, inducing the generation of
inflammatory cytokines.
Therefore, inhibitors of IRAK4 may be useful in the treatment of inflammatory disorders, including autoimmune disorders, such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), gout, Lyme arthritis, systemic lupus erythematosus (SLE), Sjogren's syndrome and viral myocarditis. (Joosten, L.A.B et al., TOLL-LIKE RECEPTORS AND CHRONIC INFLAMMATION IN RHEUMATIC DISEASES: NEW DEVELOPMENTS, Nat. Rev. Rheumatol., 346 I JUNE 2016 12; 344-357 Published online 12 May 2016) (Valaperti, A. et al., INNATE IMMUNE
INTERLEUKIN- lRECEPTOR- ASSOCIATED KINASE 4 EXACERBATES VIRAL MYOCARDITIS BY REDUCING CCR5+CDllb+ MONOCYTE MIGRATION AND IMPAIRING INTERFERON PRODUCTION, Circulation, 128 I SEPTEMBER 2013 14; 1542-1554), as well as Type I interferonopathies, such as Aicardi-Goutieres syndrome, Familial chilblain lupus, and Retinal vasculopathy with cerebral
leukodystrophy, (Lee-Kirsch et al., TYPE I INTERFERONOPATHIES— AN
EXPANDING DISEASE SPECTRUM OF IMMUNODYSREGULATION, Semin. Immunopathol. (2015) 37:349-357).
In addition, certain cancers, including lymphomas, may contain one or more mutations in the MYD88 adaptor protein, leading to a constitutively active signaling cascade that may promote survival of tumor cells. (Kelly et al., IRAK4 inhibitors for autoimmunity and lymphoma, J. Exp. Med. 2015 Vol. 212 No. 13 2189-2201)
Therefore, an inhibitor of IRAK4 may be useful in the treatment of cancers, including lymphomas.
There are currently no approved IRAK4 inhibiting pharmaceuticals. Therefore, it would be useful to provide an IRAK4 inhibiting compound with properties suitable for administration as a pharmaceutical agent to a mammal, particularly a human.
WO2016210034, WO2016210036, WO2015150995, WO2016127024, and WO2016210037 recite compounds said to be useful as IRAK4 inhibitors.
SUMMARY OF THE INVENTION Provided herein are compounds and pharmaceutical compositions useful as inhibitors of IRAK4. Some compounds of the disclosure may find use in pharmaceutical compositions, together with at least one pharmaceutically acceptable excipient, for treating a subject in need thereof. Compounds of the present disclosure also have been found to inhibit production of TNFa, IL-6, IL-Ιβ and IL-23, all of which are mediators of inflammation. The disclosure also provides compositions, including pharmaceutical compositions, kits that include the compounds, and methods of using and making the compounds.
In one embodiment of the disclosure, there is provided a compound of Formula (I)
Figure imgf000004_0001
wherein:
R1 and R2 are each independently selected from:
Ci-io alkyl optionally substituted with Z1;
C3_io cycloalkyl optionally substituted with Z1;
5- 10 membered heteroaryl optionally substituted with Z1;
C6-io aryl optionally substituted with Z1;
4- 7 membered monocyclic heterocyclyl optionally substituted with Z1;
6- 12 membered bicyclic heterocyclyl optionally substituted with Z1; or
-N(R12)( R12), -S(0)2R12, -S(0)2N(R12)( R12), or -H;
R3 and R4 are each independently selected from:
H, halo, -N02, -CN, -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)C(0 R12, -N(R12)C(0)0-R12, -N(R12)S(0)2(R12), - N(R12)C(0)-N(R12)( R12), -S(0)2R12 or -S(0)2N(R12)( R12);
Ci-9 alkyl optionally substituted with Z1;
C2_9 alkynyl optionally substituted with Z1;
C2_9 alkenyl optionally substituted with Z1 ;
5- 10 membered heteroaryl optionally substituted with Z1;
C6-io aryl optionally substituted with Z1;
4-12 membered heterocyclyl optionally substituted with Z1; or
C3-10 cycloalkyl optionally substituted with Z1;
R5, R6 and R7 are each independently selected from:
H, halo, -N02, -CN, -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)C(0 R12, -N(R12)C(0)0-R12, or -N(R12)S(0)2(R12;
Ci-5 alkyl optionally substituted with Z1; or
Cyclopropyl, oxetanyl or azetidinyl optionally substituted with Z1; Z1 is independently oxo, halo, -NO2, -N3, -CN, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)-R12, -C(0)0- R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0- R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S- R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zla;
each Zla is independently oxo, halo, -NO2, -CN, -N3, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12
or -S(0)2N(R12)( R12);
wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zlb;
each R12 is independently H, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3_i5 cycloalkyl, aryl, heteroaryl or heterocyclyl;
wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zla;
each Zlb is independently oxo, hydroxy, halo, -NO2, -N3, -CN, C1-9 alkyl, C2-6 alkenyl, C2- 6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -0(Ci_9 alkyl), -0(C2-6 alkenyl), -0(C2-6 alkynyl), -0(C3-i5 cycloalkyl), -0(Ci_8 haloalkyl), - O(aryl), -O(heteroaryl), -O(heterocyclyl), -NH2, -NH(Ci_9 alkyl), -NH(C2-6
alkenyl), -NH(C2-6 alkynyl), -NH(C3-15 cycloalkyl), -NH(Ci_8 haloalkyl), -NH(aryl), - NH(heteroaryl), -NH(heterocyclyl), -N(C1-9 alkyl)2, -N(C3-15 cycloalkyl)2, -N(C2-6 alkenyl)2, -N(C2-6 alkynyl)2, -N(C3-i5 cycloalkyl)2, -N(Ci_8 haloalkyl)2, -N(aryl)2, - N(heteroaryl)2, -N(heterocyclyl)2, -N(C1-9 alkyl)(C3-15 cycloalkyl), -N(C1-9 alkyl)(C2-6 alkenyl), -N(C1-9 alkyl)(C2-6 alkynyl), -N(C1-9 alkyl)(C3-15 cycloalkyl), -N(C1-9 alkyl)(Ci_8 haloalkyl), -N(C1-9 alkyl)(aryl), -N(C1-9 alkyl)(heteroaryl), -N(C1-9 alkyl)(heterocyclyl), -C(0)(C1-9 alkyl), -C(0)(C2-6 alkenyl), -C(0)(C2-6
alkynyl), -C(0)(C3-i5 cycloalkyl), -C(0)(d_8 haloalkyl), -C(0)(aryl), -C(0)(heteroaryl), -C(0)(heterocyclyl), -C(0)0(Ci_9 alkyl), -C(0)0(C2-6 alkenyl), -C(0)0(C2-6
alkynyl), -C(0)0(C3-i5 cycloalkyl), -C(0)0(Ci_8 haloalkyl), -C(0)0(aryl), - C(0)0(heteroaryl), -C(0)0(heterocyclyl), -C(0)NH2, -C(0)NH(Ci_9
alkyl), -C(0)NH(C2_6 alkenyl), -C(0)NH(C2_6 alkynyl), -C(0)NH(C3-i5
cycloalkyl), -C(0)NH(Ci_8 haloalkyl), -C(0)NH(aryl), -C(0)NH(heteroaryl), - C(0)NH(heterocyclyl), -C(0)N(C1-9 alkyl)2, -C(0)N(C3-15 cycloalkyl)2, -C(0)N(C2_6 alkenyl)2, -C(0)N(C2_6 alkynyl)2, -C(0)N(C3_15 cycloalkyl),, -C(0)N(d_8 haloalkyl)2, - C(0)N(aryl)2, -C(0)N(heteroaryl)2, -C(0)N(heterocyclyl)2, -NHC(0)(Ci_9
alkyl), -NHC(0)(C2_6 alkenyl), -NHC(0)(C2_6 alkynyl), -NHC(0)(C3_i5
cycloalkyl), -NHC(0)(Ci_8 haloalkyl), -NHC(0)(aryl), -NHC(0)(heteroaryl), - NHC(0)(heterocyclyl), -NHC(0)0(d_9 alkyl), -NHC(0)0(C2_6 alkenyl), -NHC(0)0(C2_ 6 alkynyl), -NHC(0)0(C3_i5 cycloalkyl), -NHC(0)0(Ci_8 haloalkyl), -NHC(0)0(aryl), - NHC(0)0(heteroaryl), -NHC(0)0(heterocyclyl), -NHC(0)NH(Ci_9
alkyl), -NHC(0)NH(C2_6 alkenyl), -NHC(0)NH(C2_6 alkynyl), -NHC(0)NH(C3_15 cycloalkyl), -NHC(0)NH(Ci_8 haloalkyl), -NHC(0)NH(aryl), - NHC(0)NH(heteroaryl), -NHC(0)NH(heterocyclyl), -SH, -S(C1-9 alkyl), -S(C2_6 alkenyl), -S(C2_6 alkynyl), -S(C3_i5 cycloalkyl), -S(C1-8 haloalkyl), -S(aryl), - S(heteroaryl), -S(heterocyclyl), -NHS(0)(Ci_9 alkyl), -N(C1-9 alkyl)(S(0)(C1-9 alkyl), - S(0)N(d_9 alkyl)2, -S(0)(d_9 alkyl), -S(0)(NH)(d_9 alkyl), -S(0)(C2_6
alkenyl), -S(0)(C2_6 alkynyl), -S(0)(C3-15 cycloalkyl), -S(0)(C1-8 haloalkyl), -S(0)(aryl), -S(0)(heteroaryl), -S(0)(heterocyclyl), -S(0)2(C1-9 alkyl), -S(0)2(C2_6
alkenyl), -S(0)2(C2_6 alkynyl), -S(0)2(C3_15 cycloalkyl), -S(0)2(d_8 haloalkyl), - S(0)2(aryl), -S(0)2(heteroaryl), -S(0)2(heterocyclyl), -S(0)2NH(Ci_9 alkyl),
or -S(0)2N(d_9 alkyl)2;
wherein any alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with one or more halo, Ci-9 alkyl, Ci_8 haloalkyl, -OH, -NH2, -NH(Ci-9 alkyl), -NH(C3_i5 cycloalkyl), -NH(Ci_8 haloalkyl), -NH(aryl), -NH(heteroaryl), -NH(heterocyclyl), -N(C1-9 alkyl)2, -N(C3_i5 cycloalkyl)2, -NHC(0)(C3_i5 cycloalkyl), -NHC(0)(Ci_8 haloalkyl), - NHC(0)(aryl), -NHC(0)(heteroaryl), -NHC(0)(heterocyclyl), -NHC(0)0(Ci_9 alkyl), -NHC(0)0(C2_6 alkynyl), -NHC(0)0(C3_i5 cycloalkyl), -NHC(0)0(Ci_8 haloalkyl), -NHC(0)0(aryl), -NHC(0)0(heteroaryl), -NHC(0)0(heterocyclyl), - NHC(0)NH(d_9 alkyl), -S(0)(NH)(Ci-9 alkyl), S(0)2(d_9 alkyl), -S(0)2(C3-15 cycloalkyl), -S(0)2(C1-8 haloalkyl), -S(0)2(aryl), -S(0)2(heteroaryl), - S(0)2(heterocyclyl), -S(0)2NH(C1_9 alkyl), -S(0)2N(d_9 alkyl)2, -0(C3-15
cycloalkyl), -0(Ci_8 haloalkyl), -O(aryl), -0(he ternary 1), -O(heterocyclyl), or -0(Ci_9 alkyl); and
with the proviso that when R1 is C3 alkyl, R2 is C5 alkyl substituted with F and hydroxyl, R3, R5, R6, R7 are H, and R4 is CN, then R1 is substituted with Z1;
or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is Ci_io alkyl optionally substituted with Z1, with the proviso that when R1 is C3 alkyl, R2 is C5 alkyl substituted with F and hydroxyl, R3, R5, R6, R7 are H, and R4 is CN, then R1 is substituted with Zl.
In another embodiment, when R1 or R2 is Ci_io alkyl, C3-10 cycloalkyl, 5-10 membered heteroaryl, C6-io aryl, 4-7 membered monocyclic heterocyclyl, or 6-12 membered bicyclic heterocyclyl, two Z1 groups either attached to the same atom on the R1 or the R2 group, or two Z1 groups attached to adjacent atoms on the R1 or the R2 group, append together to form a 3-6 membered cycloalkyl or 3-6 membered heterocyclyl.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R is
Figure imgf000007_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is methyl.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C6-io alkyl optionally substituted with
Z1. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof , R1 is Ci_5 alkyl substituted with one or more substituents selected from -CI, oxo, -CN, C2-6 alkenyl, C2-6 alkynyl, cyclopropyl, naphthyl, heteroaryl, nitrogen or sulfur containing monocyclic heterocyclyl, bicyclic heterocyclyl, C7-15 cycloalkyl, -O-R9, -C(0)-R12, -C(0)0-R12, -C(0)-N(R12)( R12), - N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), -
NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
R9 at each occurrence is independently C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, Ci_6 haloalkyl, C3-15 cycloalkyl, aryl, heterocyclyl, or heteroaryl;
wherein each C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, Ci_6 haloalkyl, C3-15 cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with Zla;
wherein said Ci-5 alkyl is also optionally substituted with Z1; and
wherein each said C2_6 alkenyl, C2_6 alkynyl, cyclopropyl, naphthyl, heteroaryl, nitrogen or sulfur containing monocyclic heterocyclyl, bicyclic heterocyclyl, or C7-i5 cycloalkyl is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
Figure imgf000008_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is Ci_5 alkyl optionally substituted with z1;
wherein said Ci-5 alkyl is substituted with one or more C4_6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or phenyl;
wherein said C4_6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or phenyl is optionally substituted with Zla;
wherein said C4_6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or phenyl is substituted by one or more halo, oxo, -CN, C2-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)-R12, -C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, - N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and wherein each said C2_6 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-7 cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is Ci-5 alkyl optionally substituted with F or -OH and substituted with one or more substituents selected from C4_6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or phenyl; wherein said C4_6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or phenyl is substituted with two or more substituents selected from -OH and -CH3 and optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C3-10 cycloalkyl optionally substituted with Z
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R is
Figure imgf000009_0001
Figure imgf000010_0001
Figure imgf000010_0002
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C3-10 cycloalkyl optionally substituted with Z
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C7-10 cycloalkyl optionally substituted with Z1, wherein when said C7-C10 cycloalkyl is bicyclo[2.2.1]heptanyl, then said C7-10 cycloalkyl is substituted with at least one of oxo, -CI, -NO2, -CN, -N3, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C7-i5 cycloalkyl, C5-8 haloalkyl, aryl, pyrazolyl, -O-R9, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, or -S(0)2N(R12)( R12).
In another embodiment, or a pharmaceutically acce table salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R is
Figure imgf000010_0003
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomer, or deuterated analog thereof, R1 is a 3-10 membered bridged bicyclic group optionally substituted with one or more Z1 group. An example of such a 3-10
membered bridged bicyclic group is
Figure imgf000011_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomer, or deuterated analog thereof, R1 is a 3-10 membered bridged hetero bicyclic group optionally substituted with 1 group. An example of such a
3-10 membered bridged bicyclic group is
Figure imgf000011_0002
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C3-6 cycloalkyl substituted with one or more -O-R16; wherein said C3-6 cycloalkyl is optionally substituted with Z1;
R16 at each occurrence is independently C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci_6 haloalkyl, C3-15 cycloalkyl, aryl, heterocyclyl, or heteroaryl; wherein each C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci_6 haloalkyl, C3-15 cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with Zla In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C3-6 cycloalkyl substituted with one or more -C(0)-Rn; wherein said C3-6 cycloalkyl is optionally substituted with Z1;
wherein R11 at each occurrence is independently Ci_g alkyl, C2-6 alkenyl, C2-6 alkynyl, C3_ ^cycloalkyl, aryl, heterocyclyl, or heteroaryl,
wherein each C1-9 alkyl is optionally substituted with -NO2, -N3, -CN, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, C4_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(O)- R12, -C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0
R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), - NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and wherein each said C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with Zla;
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C3-6 cycloalkyl substituted with one or more oxo, C5-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, heterocyclyl, -C(0)0-R12, -C(0)-N(R9)(R9), -C(0)N(H)(C4_9 alkyl), -C(O)N(H)(C3-10 cycloalkyl), -C(0)N(H)( heterocyclyl), -C(0)N(H)(aryl), -C(0)N(H)(heteroaryl) - N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), -
NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said Cs_6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3 5 cycloalkyl, aryl, heteroaryl, heterocyclyl, -C(0)N(H)(C4_9 alkyl), -C(O)N(H (C3-10 cycloalkyl), -C(0)N(H)( heterocyclyl), -C(0)N(H)(aryl), or -C(0)N(H)(heteroaryl) is optionally substituted with Zla; and wherein said C3_6 cycloalkyl is optionally substituted with Z1; wherein when C3_6 cycloalkyl is bicyclo[l.l.l]pentanyl; then said bicyclo[l.l.l]pentanyl is substituted with one or more oxo, -NO2, -N3, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C7-i5 cycloalkyl, C5-8 haloalkyl, aryl, pyrazolyl, -O-R16, -C(0)Rn, -C(0)0-R12, -C(0)N(R9)(R9), - C(0)N(H)(C4 alkyl), -C(0)N(H)(R16), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, or -S(0)2N(R12)( R12).
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R1 is
Figure imgf000012_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C3-6 cycloalkyl substituted with C4 alkyl, wherein said C4 alkyl is optionally substituted with halo, -NO2, -CN, -N3, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)-R12, - C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)- R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), - NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla; and
wherein said C3-6 cycloalkyl is optionally substituted with Z1 ;
wherein when said C3-6 cycloalkyl is bicyclo[l.l.l]pentanyl substituted with C4 alkyl then said C4 alkyl is further substituted with oxo, -N02, -N3, C5-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C7-15 cycloalkyl, C5-8 haloalkyl, aryl, heteroaryl, -O-R9, -C(0)R12, -C(0)0- R12, -C(0)N(R12)(R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, or -S(0)2N(R12)( R12).
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C3-6 cycloalkyl optionally substituted with Z1; and wherein said C3-6 cycloalkyl is substituted with four or more substituents selected from the group consisting of F, -OH, -CI, -CN, C1-3 alkyl, C1-3 fluoroalkyl, Ci_4 hydroxyalkyl, Ci_4 alkoxy, -C(0)NH2, -C(0)NH(Ci_3 alkyl); and -C(0)(Ci_3 fluoroalkyl).
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C3-6 cycloalkyl substituted with C1-3 fluoroalkyl, or -C(0)(Ci_3 fluoroalkyl) wherein said C3-6 cycloalkyl is also optionally substituted with Z1; wherein said Ci-3 fluoroalkyl or -C(0)(Ci_3 fluoroalkyl) is further substituted with at least one oxo, -CI, -N02, -CN, -N3, C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, C3-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R12, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)- C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and wherein said C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, C3-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zlb.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C3-6 cycloalkyl substituted with at least one Ci-3 alkyl or C1-4 hydroxyalkyl wherein said C3-6 cycloalkyl is optionally substituted with Z1;
wherein said C1-3 alkyl or C1-4 hydroxyalkyl is further substituted with oxo, chloro, -NO2, -CN, -N3, C4-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein said C4-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zlb .
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C3_6 cycloalkyl substituted with at least one C1-4 alkoxy or C(0)NH(Ci_3 alkyl); wherein said C3-6 cycloalkyl is optionally substituted with Z1 and wherein said C1-4 alkoxy or C(0)NH(Ci_3 alkyl) is further substituted with oxo, halo, -NO2, -CN, -N3, C4_g alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-is cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12
or -S(0)2N(R12)( R12); wherein said C4-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zlb.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is 5-10 membered heteroaryl optionally substituted with Z1. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is 5-10 membered heteroaryl optionally substituted with Z1, wherein when said 5-10 membered heteroaryl is furanyl, pyranyl, pyrraolyl, imidazolyl, pyrazolyl, triazoyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, thiaphenyl, oxazoyl, thiazoyl, said 5-10 membered heteroaryl is optionally substituted with a 5-12 membered bicyclic ring or a 5-12 membered hetero bicyclic ring, wherein the bicyclic ring and the hetero bicyclic ring may be fused, spiro or bridged.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
Figure imgf000015_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is imidazolyl, triazolyl, oxazolyl, isoxazolyl, pyridinyl, thiadiazole, oxadiazole, pyrimidinyl, pyridizinyl, pyrazinyl, isothiazolyl, tetrazolyl, thiophenyl, furanyl, triazinyl, or 8-10 membered heteroaryl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R1 is
Figure imgf000015_0002
Figure imgf000015_0003
Figure imgf000016_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R is
Figure imgf000016_0002
Figure imgf000016_0003
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is a 6 membered heteroaryl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is pyridine.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is a 4-7 membered monocyclic heterocyclyl optionally substituted with Z1. In another embodiment, or a pharmaceutically of stereoisomer
Figure imgf000017_0001
Figure imgf000017_0002
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is azetidinyl, morpholinyl,
thiomorpholinyl, 4-7 membered sultam, 4-7 membered cyclic carbamate, 4-7 membered cyclic carbonate, or 4-7 membered cyclic sulfide optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
Figure imgf000017_0003
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is 6-12 membered bicyclic heterocyclyl optionally substituted with Z1; wherein when said 6-12 membered bicyclic heterocyclyl is 4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazinyl then said 6-12 membered bicyclic heterocyclyl is substituted with at least one oxo, C3-6 cycloalkyl, or C(0)(Ci_5 alkyl).
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is 6-12 membered bicyclic optionally substituted with Z1 ; wherein when said 6-12 membered bicyclic is bicyclo[2.2.2] octane, then said 6-12 membered bicyclic is substituted with Ci_3 alkyl, C2-6 alkenyl, C2-6 alkynl, 3-6 membered cyclo alkyl, 3-6 membered heterocyclyl, 5-6 membered aryl, 5-6 membered heteroaryl, where the C1-3 alkyl, C2-6 alkenyl, C2-6 alkynl, 3-6 membered cyclo alkyl, 3-6 membered heterocyclyl, 5-6 membered aryl, 5-6 membered heteroaryl groups can further be substituted with one or more Zla group(s).
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is 6-12 membered bicyclic heterocyclyl optionally substituted with Z1 ; wherein when said 6-12 membered bicyclic heterocyclyl is 2-oxabicyclo[2.2.2]octane, then said 6-12 membered bicyclic heterocyclyl is substituted with C1-3 alkyl, C2-6 alkenyl, C2-6 alkynl, 3-6 membered cyclo alkyl, 3-6 membered heterocyclyl, 5-6 membered aryl, 5-6 membered heteroaryl, where the Ci-3 alkyl, C2-6 alkenyl, C2-6 alkynl, 3-6 membered cyclo alkyl, 3-6 membered heterocyclyl, 5-6 membered aryl, 5-6 membered heteroaryl groups can further be substituted with one or more Zla group(s).
Figure imgf000018_0001
In another embodiment, or a pharmaceuticall of
stereoisomers, or deuterated analog thereof,
Figure imgf000018_0002
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl; wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl or thiazolyl, is substituted with one or more substituents selected from -CI, oxo, -CN, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C7-10 cycloalkyl, aryl, pyridinyl, pyridizinyl, 5-10 membered bicyclic heteroaryl, 5-membered heteroaryl, nitrogen or sulfur containing monocyclic heterocyclyl, bicyclic heterocyclyl, -O-R9, -C(0)-Rn, - C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)- R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), - NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, - S-R12, -S(0)R12, -S(0)(NH)R12, or -S(0)2N(R12)( R12);wherein said C5-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C7-10 cycloalkyl, aryl, pyridinyl, pyridizinyl, 5-10 membered bicyclic heteroaryl, 5-membered heteroaryl, nitrogen or sulfur containing monocyclic heterocyclyl or bicyclic heterocyclyl is optionally substituted with Zla; wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, thiazolyl, is optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl;
wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl, is optionally substituted with Z1;
wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, thiazolyl, is substituted with 3 or more substituents selected from F, -OH, C1-4 alkyl, Ci_3 hydroxyalkyl, Ci_4 fluoroalkyl, -(CH^OCC^ alkyl), -C(0)(Ci_3 fluoroalkyl), -S(0)2(Ci_3 alkyl), C3-6 cycloalkyl, C3-6 fluorocycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrimidinyl, fluoropyrimidinyl, or methoxyprimidinyl.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is pyrrolidinyl, piperidinyl, pyrazolyl or thiazolyl; wherein said pyrrolidinyl, piperidinyl, pyrazolyl or thiazolyl is optionally substituted with Z1; wherein said pyrrolidinyl, piperidinyl, pyrazolyl or thiazolyl is substituted with one or more substituents independently selected from -(CH2)i_30(Ci_3 alkyl), -S(0)2(Ci_3 alkyl), oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or CH2(C3-6 cycloalkyl); and wherein said -(CH2)i_30(Ci_3 alkyl), -S(0)2(Ci_3 alkyl), oxetanyl, tetrahydrofuranyl, tetrahydropyranyl or CH2(C3-6 cycloalkyl) are independently substituted with one or more oxo, halo, -NO2, -CN, -N3, C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3_i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R12, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)- C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)-
N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein said C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl; wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl is optionally substituted with a -F or -OH and is substituted with one or more substituents independently selected from C1-4 alkyl or C1-3 hydroxyalkyl;
wherein said Ci_4 alkyl or Ci-3 hydroxyalkyl is substituted with one or more oxo, -CI, - NO2, -CN, -N3, C4-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C7-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R16, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein any alkyl, hydroxyalkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zlb.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl; wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl is optionally substituted with a -F or -OH and is substituted with one or more substituents independently selected from Ci_4 fluoroalkyl, - C(0)(Ci_3 fluoroalkyl), C3-6 cycloalkyl, C3-6 fluorocycloalkyl, and fluoropyrimidinyl; wherein said Ci_4 fluoroalkyl, -C(0)(Ci_3 fluoroalkyl), C3-6 cycloalkyl, C3-6
fluorocycloalkyl or fluoropyrimidyl is substituted with one or more oxo, -CI, -NO2, -CN, -N3, C4-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)-
N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zlb
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C6-io aryl optionally substituted with Z1.
Figure imgf000021_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C6-io aryl is substituted with one or more Ci_6 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)Rn, -C(0)0-R12, -C(0)NH(C3-6 cycloalkyl), -C(0)NH(C4-6 alkyl), - C(0)heterocyclyl, N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, - N(R1Z)C(0)N(R1Z)( R1Z), -N(R1Z)S(0)2(R ), -NR1ZS(0)2N(R1Z)( R1Z), - NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said Ci_6 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3 5 cycloalkyl, aryl, heteroaryl, heterocyclyl, -C(0)NH(C3-6 cycloalkyl), -C(0)NH(C4-6 alkyl),or -C(0)heterocyclyl is optionally substituted with Zla;
wherein said C6-io aryl is optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C6-io aryl substituted with one or more -C(0)NH(Ci_3 alkyl) and optionally substituted with Zla;
wherein said -C(0)NH(Ci_3 alkyl) is substituted with one or more oxo, halo, -N02, -CN, -N3, C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3 5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is C6-io aryl substituted with one or more -C(0)(Ci_3 fluoroalkyl); wherein said -C(0)(Ci_3 fluoroalkyl) is substituted with one or more oxo, -CI, -N02, -CN, -N3, C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, C3- 8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), - N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), - N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, - S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3 5 cycloalkyl, C3-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb; and
wherein said C6-io aryl is optionally substituted with Z1. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is -N(R12)( R12), - S(0)2R12, -S(0)2N(R12)( R12), or -H.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R is
Figure imgf000023_0001
* .
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is Ci_io alkyl optionally substituted with
Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is Ci_io alkyl.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is methyl.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C7-io alkyl, optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is Ci_6 alkyl substituted with one or more -0(Ci_2 alkyl), -NHC(0)(Ci_3 alkyl), or -S(0)2(C1-3 alkyl); wherein said -0(C1-2 alkyl) is substituted with one or more oxo, -CI, -N02, -CN, -N3, C2-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-i5 cycloalkyl, C2-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-
R12, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)- C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and said -0(Ci_2 alkyl) is optionally substituted with -F; wherein said -NHC(0)(Ci_3 alkyl), or -S(0)2(Ci_3 alkyl) is substituted with one or more oxo, halo, -NO2, -CN, -N3, C3_9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R , -C(0)R , -C(0)0-R , -C(0)N(R1Z)( R1Z), -N(R1Z)( R1Z), - N(R12)2(Rl ) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said Ci_6 alkyl is optionally substituted with Zla; and wherein each said C2_9 alkyl, C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3 5 cycloalkyl, Ci-8 haloalkyl, C2_8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R > ius - :a--"- o c
Figure imgf000024_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C4_6 alkyl substituted with one or more substituents selected from -CI, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, monocyclic heterocyclyl, bicyclic heterocyclyl, -0(C3_9 alkyl), -0(C3-io cycloalkyl), -O(heterocyclyl), -O(aryl), -O(heteroaryl), -C(0)-R12, -C(0)0-R12, -C(O)- N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)(C4_9 alkyl), -N(R12)C(0)(C3_io cycloalkyl), -N(R12)C(0)(heterocyclyl), -N(R12)C(0)(aryl), -N(R12)C(0)(
heteroaryl), -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), - NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, - S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2(C4_9 alkyl), -S(0)2(aryl), -S(O)2(C3.10 cycloalkyl), -S(0)2(heterocyclyl), - S(0)2(heteroaryl), or -S(0)2N(R12)( R12); wherein said C4_6 alkyl is also optionally substituted with Z1 ; and
wherein said C2_6 alkenyl, C2_6 alkynyl, C3-i5 cycloalkyl, aryl, heteroaryl, monocyclic heterocyclyl, bicyclic heterocyclyl, -0(C3_9 alkyl), -0(C3-io cycloalkyl), -O(heterocyclyl), -O(aryl), -O(heteroaryl), -N(R12)C(0)(C4_9 alkyl), -N(R12)C(0)(C3_io cycloalkyl), - N(R1Z)C(0)( heterocyclyl), -N(Rlz)C(0)(aryl), -N(R1Z)C(0)( heteroaryl), -S(0)2(C4_9 alkyl), -S(0)2(aryl), -S(0)2(C3-1o cycloalkyl), -S(0)2(heterocyclyl), - S(0)2(heteroaryl), - NHC(0)(Ci_3 alkyl), or -S(0)2(C1-3 alkyl) is optionally substituted with Zla. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C4_6 alkyl substituted with one or more -0(CH2)2R17 or -0(CH2)R17; R17 at each occurrence is independently C3-15 cycloalkyl, aryl, heterocyclyl, heteroaryl, -O-R12, -C(0)-R12, -C(0)0-R12, -C(0)-N(R12)( R12), - N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, - N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), -
NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein saidC3_i5 cycloalkyl, aryl, heterocyclyl, and heteroaryl optionally is substituted with Zlb; and wherein said C4_6 alkyl is also optionally substituted with Z1
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C4_6 alkyl substituted with five or more substituents selected from F, hydroxyl, -CN, -OCH3, -OCD3, -NHC(0)(Ci_3 alkyl), - S(0)2(Ci_3 alkyl), or Ci-2 fluoroalkoxy; and wherein said C4_6 alkyl is optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is Ci_3 alkyl substituted with one or more substituents selected from -CI, C2_6 alkenyl, C2_6 alkynyl, cyclopropyl, napthyl, bicyclic heterocyclyl, C7-15 cycloalkyl, -0(CH2)2R17, -0(CH2)R17, -0(C3-9 alkyl), -O(C3-10 cycloalkyl), -O(heterocyclyl), -O(aryl), -O(heteroaryl), -C(0)(Ci-9 alkyl), - C(0)(cyclopropyl), -C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, - N(R12)C(0)(C4_9 alkyl), -N(R12)C(0)(C3-io cycloalkyl), -N(R12)C(0)(heterocyclyl), - N(R12)C(0)(aryl), -N(R12)C(0)( heteroaryl), -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), -
NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2(C4_9 alkyl), -S(0)2(aryl), -S(0)2(C3-io cycloalkyl), - S(0)2(heterocyclyl), - S(0)2(heteroaryl), or -S(0)2N(R9)(R12);
wherein said Ci-3 alkyl is also optionally substituted with Z1; and wherein said C2-6 alkenyl, C2-6 alkynyl, cyclopropyl, napthyl, bicyclic heterocyclyl,C7_i5 cycloalkyl , -0(C3_g alkyl), -0(C3_io cycloalkyl), -O(heterocyclyl), -O(aryl), - O(heteroaryl), -N(R12)C(0)(C4_9 alkyl), -N(R12)C(0)(C3-io cycloalkyl), -N(R12)C(0)( heterocyclyl), -N(R12)C(0)(aryl), -N(R12)C(0)(heteroaryl), -S(0)2(C4_9 alkyl), - S(0)2(aryl), -S(0)2(C3-1o cycloalkyl), -S(0)2(heterocyclyl), or - S(0)2(heteroaryl) is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R is O O 0r
Figure imgf000026_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C1-3 alkyl substituted with one or more substituents selected from azetidinyl, tetrahydrofuranyl, triazolyl, oxazolyl, isoxazolyl, thiadiazole, oxadiazole, pyrimidinyl, pyridizinyl, pyrazinyl, isothiazolyl, tetrazolyl, furanyl, thiomorpholinyl, 4-7 membered sultam, 4-7 membered cyclic carbamate, 4-7 membered cyclic carbonate, 4-7 membered cyclic sulfide, or 8-10 membered heteroaryl; any of which is optionally substituted with Zla; and wherein said C1-3 alkyl is also optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R2 is
Figure imgf000026_0002
Figure imgf000026_0003
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C1-3 alkyl substituted with one substituent selected from phenyl, oxetanyl, tetrahydropyranyl, morpholinyl, piperidinyl, imidazolyl, pyridinyl, thiophenyl, or C4_6 cycloalkyl ;
wherein said phenyl, oxetanyl, tetrahydropyranyl, morpholinyl, piperidinyl, imidazolyl, pyridinyl, thiophenyl, or C4_6 cycloalkyl is substituted with one or more oxo, -N02, -N3, - CN, C4-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3 5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -0(C3_6 alkyl), -0(C3_6 cycloalkyl), -O(heterocyclyl), -C(0)-R12, - C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)- R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), - NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, - S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R9)(R12); and
wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or
heterocyclyl is optionally substituted with Zla. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C1-3 alkyl optionally substituted with Z1 and is substituted with one substituent selected from phenyl, oxetanyl, tetrahydropyranyl, morpholinyl, piperidinyl, imidazolyl, pyridinyl, thiophenyl, or C4_6 cycloalkyl;
wherein said phenyl, oxetanyl, tetrahydropyranyl, morpholinyl, piperidinyl, imidazolyl, pyridinyl, thiophenyl, or C4_6 cycloalkyl is substituted with four or more substituents selected from -F, -CI, -OH, C1-3 alkyl, -0(d_2 alkyl) or -S(0)2NH2.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C1-3 alkyl substituted with oxo and optionally substituted with one or more substituents selected from halo, azetidinyl, pyrrolidinyl, piperazinyl, tetrahydrofuranyl, thiomorpholinyl, -CN, C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, cyclopropyl, C7-i5 cycloalkyl, Ci-8 haloalkyl, -O-R12, -C(0)-R12, - C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)- R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), - NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, - S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R9)(R12); and wherein said Ci_3 alkyl is optionally substituted with Z1;
wherein said, C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, cyclopropyl, C7-i5 cycloalkyl, Ci-8 haloalkyl, azetidinyl, pyrrolidinyl, piperazinyl, tetrahydrofuranyl, or thiomorpholinyl is optionally substituted with Zla .
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C3 alkyl substituted with five or more substituents selected from -F, -OH, -OCH3, -CN, -NHC(0)(Ci_3 alkyl), Ci_2
fluoroalkoxy, or -S(0)2(Ci_3 alkyl).
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C3-10 cycloalkyl optionally substituted with Z of
Figure imgf000028_0001
In another embodiment, or a pharmaceutically acce table salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R2 is
Figure imgf000028_0002
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is cyclopropyl optionally substituted with
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C7-10 cycloalkyl optionally substituted with Z
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of or deuterated analog thereof, R is HO ; HO 0r
Figure imgf000028_0003
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C4_6 cycloalkyl substituted with one or more substituents selected from -halo, oxo, -CN, Ci_4 alkyl, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -0(C4_9 alkyl), - 0(C3-io cycloalkyl), -O(heterocyclyl), -O(aryl), -O(heteroaryl), -N(R12)C(0)(C5-9 alkyl), -N(R12)C(0)(C3-io cycloalkyl), -N(R12)C(0)(heterocyclyl), -N(R12)C(0)(aryl), - N(R12)C(0)(heteroaryl), -NH(R12), -N(R12)(C4_9 alkyl), -N(R12)(C3-io cycloalkyl), - N(R12)(heterocyclyl), -N(R12)(aryl), -N(R12)(heteroaryl), -N(R12)C(0)0(C4_9 alkyl), - N(R12)C(0)0(C3-io cycloalkyl), -N(R12)C(0)0( heterocyclyl), -N(R12)C(0)0(aryl), - N(R12)C(0)0(heteroaryl), -C(0)N(R12)(C5-9 alkyl), -C(0)N(R12)(C7-io cycloalkyl), -
C(0)N(R12)(heterocyclyl), -C(0)N(R12)(aryl), -C(0)N(R12)(heteroaryl), -C(0)N(R9)(R9), -C(0)0-R12, -N(R12)2(R12)+, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), - NR12S(0)2N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)-N( 12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)2R12, -S(0)(NH)R12, or -S(0)2N(R12)( R12); wherein said C4_6 cycloalkyl is also optionally substituted with Z1; wherein said Ci_4 alkyl is optionally substituted with oxo, halo, -N02, -CN, -N3, C4_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3_u cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R16, -0(C4_9
alkyl), -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)- C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(0)-N(R12)( R12
R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and wherein each said Cs_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3_i5 cycloalkyl, Ci-8 haloalkyl, - 0(C4_9 alkyl), -0(C3_io cycloalkyl), -O(heterocyclyl), -O(aryl), -O(heteroaryl), - N(R12)C(0)(C5-9 alkyl), -N(R12)C(0)(C3_io cycloalkyl), -N(R12)C(0)(heterocyclyl), - N(R12)C(0)(aryl), -N(R12)C(0)(heteroaryl), -N(R12)(C4_9 alkyl), -N(R12)(C3_io cycloalkyl), -N(R12)(heterocyclyl), -N(R12)(aryl), -N(R12)(heteroaryl), -N(R12)C(0)0(C4_9 alkyl), -N(R12)C(0)0(C3_io cycloalkyl), -N(R12)C(0)0(heterocyclyl), - N(R12)C(0)0(aryl), -N(R12)C(0)0(heteroaryl), -C(0)N(R12)(C5-9 alkyl), - C(0)N(R12)(C7_io cycloalkyl), -C(0)N(R12)(heterocyclyl), -C(0)N(R12)(aryl), - C(0)N(R12)(heteroaryl), aryl, heteroaryl, or heterocyclyl is optionally substituted with In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R2
Figure imgf000030_0001
Figure imgf000030_0002
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C4_6 cycloalkyl substituted with one or more substituents selected from Ci_4 hydroxyalkyl, C1-3 alkoxy, -(CH2)i-30(Ci_3 alkyl), - C(0)NH(d_4 alkyl), -C(0)NH(C3-6 cycloalkyl), -N(C1-3 alkyl)2, -NHC(0)0(C1-3 alkyl), - NHC(0)(Ci_4 hydroxyalkyl); wherein said C4_6 cycloalkyl is optionally substituted with Z1;
wherein said -C(0)NH(C3_6 cycloalkyl) is substituted with Zla; wherein said Ci_4 hydroxyalkyl or -NHC(0)(Ci_4 hydroxyalkyl) is substituted with oxo, halo, -NO2, -CN, - N3, C4_9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), - N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said Ci_3 alkoxy, -(CH2)i-30(Ci_3 alkyl), -N(C1-3 alkyl)2, -NHC(0)0(Ci_3 alkyl) is substituted with oxo, halo, -NO2, -CN, -N3, C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-i5 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S- R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein said -
C(0)NH(Ci_4 alkyl) is substituted with oxo, halo, -N02, -CN, -N3, C4_9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R12, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)- C(0)R , -N(R1Z)C(0)0(R1Z), -N(R1Z)C(0)N(R1Z)( R1Z), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R1: or -S(0)2N(R12)( R12); and wherein each said C3_9 alkyl, C4_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R2 is
Figure imgf000031_0001
Figure imgf000031_0002
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C4_6 cycloalkyl substituted with one or more -NHC(0)(Ci_3 alkyl); wherein at least one -NHC(0)(Ci_3 alkyl) is substituted with one or more oxo, halo, -N02, -CN, -N3, C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein said C4_6 cycloalkyl is optionally substituted with Z1; and
wherein said C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3 5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R2 is
Figure imgf000031_0003
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C4_6 cycloalkyl substituted with three or more substituents selected from -OH, Ci_4 hydroxyalkyl, C1-3 alkoxy, -(CH2)i-30(Ci_3 alkyl), -C(0)NH(Ci_4 alkyl), -C(0)NH(C3-6 cycloalkyl), -N(C1-3 alkyl)2, -NHC(0)(Ci_3 alkyl), -NHC(0)0(Ci_3 alkyl), or -NHC(0)(Ci_4 hydroxyalkyl); and wherein said C4_6 cycloalkyl is optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is s 5-10 membered heteroaryl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is oxazolyl, isoxazolyl, thiadiazole, thiazole, oxadiazole, isothiazolyl, tetrazolyl, thiophenyl, furanyl, or a 6-10 membered heteroaryl; any of which is optionally substituted with Z1;
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is 4-7 membered monocyclic
heterocyclyl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
/
O.
stereoisomers, or deuterated analog thereof, R2 is ΟΥ f , 0°Υ ? „ orΓ 0¾ In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is azetidinyl, oxetanyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, 4-7 membereded sultam, 4-7 membered cyclic carbamate, 4-7 membered cyclic carbonate, or 4-7 membered cyclic sulfide; any of which is optionally substituted with Z1. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R2 is
Figure imgf000033_0001
Figure imgf000033_0002
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl;
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more substituents selected from oxo, halo, -CN, C2-4 alkyl, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_ 8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)-R12, -C(0)0-R12, -C(O)- N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, - N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)2(C4-9 alkyl), -S(0)2(C3-1o cycloalkyl), -S(0)2(heterocyclyl), -S(0)2(aryl), - S(0)2(heteroaryl), -S(0)(NH)R12,or -S(0)2N(R12)( R12);
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is optionally substituted with Zla;
wherein said C2-4 alkyl is optionally substituted with halo, -NO2, -CN, -N3, alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl,
heterocyclyl, -O-R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), - N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein each said C3-9 alkyl, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -S(0)2(C4_9 alkyl), -S(0)2(C3_io cycloalkyl), - S(0)2(heterocyclyl), -S(0)2(aryl), or -S(0)2(heteroaryl) is optionally substituted with Zla. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R2 is
Figure imgf000034_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl;
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more Ci alkyl;
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is optionally substituted with Z1 ;
wherein said Ci alkyl is optionally substituted with oxo, halo, -NO2, -CN, -N3, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R9, -C(0)R12, -C(0)0-R12, -C(0)N(R9)( R9), - C(0)N(R12)(C4_9 alkyl), - C(0)N(R12)(C3- 10 cycloalkyl), - C(0)N(R12)(heterocyclyl), - C(0)N(R12)(aryl), - C(0)N(R12)(heteroaryl), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -
N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and wherein said C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, - C(0)N(R12)(C3-io cycloalkyl), - C(0)N(R12)(heterocyclyl), - C(0)N(R12)(aryl), - C(0)N(R12)(heteroaryl) is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl; any of which is optionally substituted with Z1 ; wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more S(0)2(Ci_3 alkyl); wherein said S(0)2(Ci_3 alkyl) is substituted with oxo, halo, -N02, -CN, -N3, C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0-
R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R1Z)C(0)0(R1Z), -N(R1Z)C(0)N(R1Z)( R1Z), -N(R1Z)S(0)2(R ), -N(R1Z)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and wherein said C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl; any of which is optionally substituted with Z1; wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more C1-4 hydroxyalkyl; wherein said C1-4 hydroxyalkyl is substituted with oxo, halo, -N02, -CN, -N3, C4_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3_i5 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -
N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and wherein said C4-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl; any of which is optionally substituted with Z1; wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more -CH2C(0)NH(Ci_6 alkyl); wherein said -CH2C(0)NH(Ci_6 alkyl) is substituted with oxo, -CI, -N02, -CN, -N3, C6-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -
N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein said -CH2C(0)NH(Ci_6 alkyl) is optionally substituted with Zla; and wherein said C6-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl;
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more -CH2C(0)NH(C4_6 alkyl); and wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is C6-io aryl optionally substituted with
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is 6-12 membered bicyclic heterocyclyl optionally substituted with Z1; wherein when said 6-12 membered bicyclic heterocyclyl is l-oxa-7-azaspiro[3.5]nonanyl, then said l-oxa-7-azaspiro[3.5]nonanyl is substituted with one or more Z .
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R2 is
Figure imgf000036_0001
.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R2 is -N(R12)( R12), -S(0)2R12, -S(0)2N(R12)( R12); or -H. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R2 is
Figure imgf000037_0001
or -H.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is selected from H, halo, -NO2, -CN, -O- R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)S(0)2(R12), -N(R12)C(0)-N(R12)( R12), -S(0)2R12 ), -SR12 and -S(0)2N(R12)( R12).
In another embodiment, a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is selected from -O-R12, -C(O)- R12, -C(0)-N(R12)( R12), -N(R9)( R9), -NH(R9), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, - N(R12)S(0)2(R12), -N(R12)C(0)-N(R12)( R12), -S(0)2(R12 ), -S-R12 or -S(0)2N(R12)( R12); wherein when said -N(H)(R9) is NH(Ci_3 alkyl), -N(H)(R9) is NH(Ci_4 hydroxy alkyl), or -O-R12 is -0(Ci_3 alkyl), then said NH(Ci_3 alkyl), NH(Ci_4 hydroxy alkyl), or -0(Ci_3 alkyl) is further substituted with one or more oxo, halo, -N02, -CN, -N3, C4_g alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)- C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein said C4_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3 5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R3 is
Figure imgf000037_0002
In another embodiment, a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is selected from -0(C4 alkyl) or -N(H)(C4 alkyl); wherein said -0(C4 alkyl) is optionally substituted with Zla; wherein said - N(H)(C4 alkyl) is optionally substituted with oxo, halo, -N02, -CN, -N3, Ci_9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)- C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein said C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3 5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is C1-9 alkyl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is Ci-2 alkyl optionally substituted with F and further substituted with one or more oxo, -CI, -N02, -N3, -CN, C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R12, -C(0)-R12, -C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), - N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein said C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is
Figure imgf000038_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is C3 alkyl substituted with one or more Z In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is C4-9 alkyl optionally substituted with Z
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is C2-9 alkynyl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of
stereoisomers, or deuterated analog thereof, R3 is
Figure imgf000039_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is C2-9 alkenyl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is a 5-10 membered heteroaryl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is a 5-10 membered heteroaryl optionally substituted with Z1; wherein if said 5-10 membered heteroaryl is pyridinyl, then said pyridinyl is further substituted with one or more Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is C6-io aryl optionally substituted with In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is C6-io aryl optionally substituted with Z1;
wherein when said C6-io aryl is cyanophenyl then said cyanophenyl is further substituted with one or more oxo, halo, -NO2, -N3, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and wherein said C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is a 4-12 membered heterocyclyl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is a 4-12 membered heterocyclyl optionally substituted with Z1; wherein when said 4-12 membered heterocyclyl is hydroxypyrrolidinyl then said hydroxypyrrolidinyl is further substituted with one or more oxo, halo, -CN, -N02, -N3, C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein said C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is C3-10 cycloalkyl optionally substituted with Z In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is C3_6 cycloalkyl substituted with one or more Z1. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is C7-io cycloalkyl optionally substituted with Z
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is H, halo, -NO2, -CN, -O-R12, -C(O)- R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, - N(R12)S(0)2(R12), -N(R12)C(0)-N(R12)( R12), -S(0)2R12 ), -SR12 or -S(0)2N(R12)( R12).
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R is
Figure imgf000041_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R9)( R9), -NH(R9), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -
N(R12)S(0)2(R12), -N(R12)C(0)-N(R12)( R12), -S(0)2(R12 ), -S-R12 or -S(0)2N(R12)( R12); wherein when said -N(H)( R9) is NH(Ci_3 alkyl), -N(H)( R9) is NH(Ci_4 hydroxy alkyl), or -O-R12 is -0(Ci_3 alkyl), then said NH(Ci_3 alkyl), NH(Ci_4 hydroxy alkyl), or -0(Ci_3 alkyl) is further substituted with one or more oxo, halo, -N02, -CN, -N3, C4_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)- C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and wherein said C4_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is selected from -0(C4 alkyl) or -N(H)(C4 alkyl); wherein said -0(C4 alkyl) is optionally substituted with Zla;
wherein said -N(H)(C4 alkyl) is optionally substituted with oxo, halo, -NO2, -CN, -N3, Ci-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)(V), -N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is C1-9 alkyl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is Ci-2 alkyl optionally substituted with F and further substituted with one or more oxo, -CI, -N02, -N3, -CN, C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R12, -C(0)-R12, -C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), - N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and wherein said C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is C3 alkyl substituted with one or more In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is C4_g alkyl optionally substituted with Z In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is C2-9 alkynyl optionally substituted with
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is C2-9 alkenyl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is a 5-10 membered heteroaryl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is
Figure imgf000043_0001
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is a 5-10 membered heteroaryl optionally substituted with Z1; wherein when said 5-10 membered heteroaryl is pyridinyl then said pyridinyl is further substituted with one or more Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is C6-io aryl optionally substituted with Z1. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is C6-io aryl optionally substituted with Z1; wherein when said C6-io aryl is cyanophenyl then said cyanophenyl is further substituted with one or more oxo, halo, -NO2, -N3, Ci_g alkyl, C2-6 alkenyl, C2-6 alkynyl, C3 5 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and wherein said C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is a 4-12 membered heterocyclyl optionally substituted with Z1. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is a 4-12 membered heterocyclyl optionally substituted with Z1; wherein when said 4-12 membered heterocyclyl is hydroxypyrrolidinyl then said hydroxypyrrolidinyl is further substituted with one or more oxo, halo, -CN, -N02, -N3, C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein said C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is C3-10 cycloalkyl optionally substituted with Z
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is C3-6 cycloalkyl substituted with one or more Z1. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is C7-io cycloalkyl optionally substituted with Z
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, at least one of R5, R6 or R7 is independently selected from H, halo, -N02, -CN, -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R9)( R9), NH(R9), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, or -N(R12)S(0)2(R12).
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, at least one of R5, R6 or R7 is independently selected from -N02, -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R9)( R9), -N(R12)C(0)- R12, -N(R12)C(0)0-R12, or -N(R12)S(0)2(R12).
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, at least one of R5, R6 or R7 is independently Ci-5 alkyl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, at least one of R5, R6 or R7 is independently Ci-2 alkyl optionally substituted with F and substituted with one or more oxo, -CI, -N02, - N3, -CN, C3_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)-R12, -C(0)0-R12, -C(0)-N(R12)( R12), - N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, - N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zla.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, at least one of R5, R6 or R7 is independently C3 alkyl substituted with one or more Z1. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, at least one of R5, R6 or R7 is independently C4-5 alkyl optionally substituted with Z1.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, at least one of R5, R6 or R7 is independently cyclopropyl, oxetanyl, or azetidinyl optionally substituted with Z1. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, at least one of R5, R6 or R7 is independently cyclopropyl, oxetanyl, or azetidinyl; wherein said cyclopropyl is substituted with one or more Z1; wherein said oxetanyl or azetidinyl is optionally substituted with Z1. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, no more than two of R3, R4, R5, R6 or R7 are H.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R3 is H or F.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R4 is H, F, -CN or CI. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R5 is H or F.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R6 is H or F.
In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R7 is H or F. In another embodiment, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, Z1 is selected H, halo, -CN, Ci_g alkyl, C3_i5 cycloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), - N(R12)( R12), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)S(0)2(R12), -OC(0)-N(R12)( R12), -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein any alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zla.
Another embodiment of the present disclosure provides a pharmaceutical composition comprising a compound of the disclosure, together with a pharmaceutically acceptable carrier, and optionally a diluent.
Another embodiment of the present disclosure provides a method of treating an inflammation related disease or disorder in a patient in need thereof, comprising administering to said patient a compound of the disclosure, or a pharmaceutical composition thereof.
DETAILED DESCRIPTION OF THE INVENTION
Definitions The following description sets forth exemplary methods, parameters and the like.
It should be recognized, however, that such description is not intended as a limitation on the scope of the present disclosure but is instead provided as a description of exemplary embodiments.
A dash ("-") that is not between two letters or symbols is used to indicate a point of attachment for a substituent. For example, -C(0)NH2 is attached through the carbon atom. A dash at the front or end of a chemical group is a matter of convenience;
chemical groups may be depicted with or without one or more dashes without losing their ordinary meaning. A wavy line drawn through a line in a structure indicates a point of attachment of a group. Unless chemically or structurally required, no directionality is indicated or implied by the order in which a chemical group is written or named. The prefix "Cu_v" indicates that the following group has from u to v carbon atoms. For example, "Ci_6 alkyl" indicates that the alkyl group has from 1 to 6 carbon atoms.
Reference to "about" a value or parameter herein includes (and describes) embodiments that are directed to that value or parameter per se. In certain embodiments, the term "about" includes the indicated amount + 10%. In other embodiments, the term "about" includes the indicated amount + 5%. In certain other embodiments, the term "about" includes the indicated amount ± 1%. Also, to the term "about X" includes description of "X". Also, the singular forms "a" and "the" include plural references unless the context clearly dictates otherwise. Thus, e.g., reference to "the compound" includes a plurality of such compounds and reference to "the assay" includes reference to one or more assays and equivalents thereof known to those skilled in the art.
"Alkyl" refers to an unbranched or branched saturated hydrocarbon chain. As used herein, alkyl has 1 to 20 carbon atoms (i.e., Ci_2o alkyl), 1 to 8 carbon atoms (i.e., Ci-8 alkyl), 1 to 6 carbon atoms (i.e. , Ci_6 alkyl), or 1 to 4 carbon atoms (i.e. , C1-4 alkyl). Examples of alkyl groups include methyl, ethyl, propyl, isopropyl, n-butyl, sec -butyl, iso-butyl, tert-butyl, pentyl, 2-pentyl, isopentyl, neopentyl, hexyl, 2-hexyl, 3-hexyl, and 3-methylpentyl. When an alkyl residue having a specific number of carbons is named by chemical name or identified by molecular formula, all positional isomers having that number of carbons may be encompassed; thus, for example, "butyl" includes n-butyl (i.e. -(CH2)3CH3), sec-butyl (i.e. -CH(CH3)CH2CH3), isobutyl (i.e. -CH2CH(CH3)2) and tert- butyl (i.e. -C(CH3)3); and "propyl" includes n-propyl (i.e.
-(CH2)2CH3) and isopropyl (i.e. -CH(CH3)2).
"Alkenyl" refers to an alkyl group containing at least one carbon-carbon double bond and having from 2 to 20 carbon atoms (i.e. , C2_2o alkenyl), 2 to 8 carbon atoms (i.e. , C2_8 alkenyl), 2 to 6 carbon atoms (i.e. , C2_6 alkenyl), or 2 to 4 carbon atoms (i.e. , C2_4 alkenyl). Examples of alkenyl groups include ethenyl, propenyl, butadienyl (including 1,2-butadienyl and 1,3 -butadienyl).
"Alkynyl" refers to an alkyl group containing at least one carbon-carbon triple bond and having from 2 to 20 carbon atoms (i.e., C2_2o alkynyl), 2 to 8 carbon atoms (i.e. , C2_8 alkynyl), 2 to 6 carbon atoms (i.e. , C2_6 alkynyl), or 2 to 4 carbon atoms (i.e., C2_4 alkynyl). The term "alkynyl" also includes those groups having one triple bond and one double bond.
"Alkoxy" refers to the group "alkyl-O-". Examples of alkoxy groups include methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, tert-butoxy, sec-butoxy, n-pentoxy, n-hexoxy, and 1,2-dimethylbutoxy.
"Haloalkoxy" refers to an alkoxy group as defined above, wherein one or more hydrogen atoms are replaced by a halogen.
"Alkylthio" refers to the group "alkyl-S-".
"Amino" refers to the group -NRyRy wherein each Ry is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, cycloalkyl or heteroaryl, each of which is optionally substituted, as defined herein.
"Aryl" refers to an aromatic carbocyclic group having a single ring (e.g.
monocyclic) or multiple rings (e.g. bicyclic or tricyclic) including fused systems. As used herein, aryl has 6 to 20 ring carbon atoms (i.e. , C6-2o aryl), 6 to 12 carbon ring atoms (i.e. , C6-i2 aryl), or 6 to 10 carbon ring atoms (i.e. , C6-io aryl). Examples of aryl groups include phenyl, naphthyl, fluorenyl, and anthryl. Aryl, however, does not encompass or overlap in any way with heteroaryl defined below. If one or more aryl groups are fused with a heteroaryl, the resulting ring system is heteroaryl. If one or more aryl groups are fused with a heterocyclyl, the resulting ring system is heterocyclyl. "Cyano" refers to the group -CN.
"Keto" or "oxo" refers to a group =0.
"Carbamoyl" refers to both an "O-carbamoyl" group which refers to the group - 0-C(0)NRyRz and an "N-carbamoyl" group which refers to the group -NRyC(0)ORz, wherein Ry and Rz are independently selected from the group consisting of hydrogen, alkyl, aryl, haloalkyl, or heteroaryl; each of which may be optionally substituted.
"Carboxyl" refers to -C(0)OH.
"Ester" refers to both -OC(0)R and -C(0)OR, wherein R is a substituent; each of which may be optionally substituted, as defined herein. "Cycloalkyl" refers to a saturated or partially unsaturated cyclic alkyl group having a single ring or multiple rings including fused, bridged, and spiro ring systems. The term "cycloalkyl" includes cycloalkenyl groups (i.e. the cyclic group having at least one double bond). As used herein, cycloalkyl has from 3 to 20 ring carbon atoms (i.e. , C3-20 cycloalkyl), 3 to 12 ring carbon atoms (i.e. , C3-i2 cycloalkyl), 3 to 10 ring carbon atoms (i.e. , C3-io cycloalkyl), 3 to 8 ring carbon atoms (i.e. , C3_8 cycloalkyl), or 3 to 6 ring carbon atoms (i.e. , C3_6 cycloalkyl). Examples of cycloalkyl groups include cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl.
"Halogen" or "halo" includes fluoro, chloro, bromo, and iodo. "Haloalkyl" refers to an unbranched or branched alkyl group as defined above, wherein one or more hydrogen atoms are replaced by a halogen. For example, where a residue is substituted with more than one halogen, it may be referred to by using a prefix corresponding to the number of halogen moieties attached. Dihaloalkyl and trihaloalkyl refer to alkyl substituted with two ("di") or three ("tri") halo groups, which may be, but are not necessarily, the same halogen. Examples of haloalkyl include difluoromethyl (-CHF2) and trifluoromethyl (-CF3).
"Heteroalkyl" refers to an alkyl group in which one or more of the carbon atoms (and any associated hydrogen atoms) are each independently replaced with the same or different heteroatomic group. The term "heteroalkyl" includes unbranched or branched saturated chain having carbon and heteroatoms. By way of example, 1, 2 or 3 carbon atoms may be independently replaced with the same or different heteroatomic group. Heteroatomic groups include, but are not limited to, -NR-, -0-, -S-, -S(O)-, -S(0)2-, and the like, where R is H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl or heterocyclyl, each of which may be optionally substituted. Examples of heteroalkyl groups include - OCH3, -CH2OCH3, -SCH3, -CH2SCH3, -NRCH3, and -CH2NRCH3, where R is hydrogen, alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl, each of which may be optionally substituted. As used herein, heteroalkyl include 1 to 10 carbon atoms, 1 to 8 carbon atoms, or 1 to 4 carbon atoms; and 1 to 3 heteroatoms, 1 to 2 heteroatoms, or 1 heteroatom. "Heteroaryl" refers to an aromatic group having a single ring, multiple rings, or multiple fused rings, with one or more ring heteroatoms independently selected from nitrogen, oxygen, and sulfur. As used herein, heteroaryl includes 1 to 20 ring carbon atoms (i.e. , Ci-20 heteroaryl), 3 to 12 ring carbon atoms (i.e. , C3-i2 heteroaryl), or 3 to 8 carbon ring atoms (i.e. , C3_8 heteroaryl); and 1 to 5 heteroatoms, 1 to 4 heteroatoms, 1 to 3 ring heteroatoms, 1 to 2 ring heteroatoms, or 1 ring heteroatom independently selected from nitrogen, oxygen, and sulfur. Examples of heteroaryl groups include pyrimidinyl, purinyl, pyridyl, pyridazinyl, benzothiazolyl, and pyrazolyl. Examples of the fused- heteroaryl rings include, but are not limited to, benzo[d]thiazolyl, quinolinyl, isoquinolinyl, benzo[b]thiophenyl, indazolyl, benzo[d]imidazolyl, pyrazolo[l,5- ajpyridinyl, and imidazo[l,5-a]pyridinyl, where the heteroaryl can be bound via either ring of the fused system. Any aromatic ring, having a single or multiple fused rings, containing at least one heteroatom, is considered a heteroaryl regardless of the attachment to the remainder of the molecule (i.e., through any one of the fused rings). Heteroaryl does not encompass or overlap with aryl as defined above.
"Heterocyclyl" refers to a saturated or unsaturated cyclic alkyl group, with one or more ring heteroatoms independently selected from nitrogen, oxygen and sulfur. The term "heterocyclyl" includes heterocycloalkenyl groups (i.e. the heterocyclyl group having at least one double bond), bicyclic heterocyclyl groups, bridged-heterocyclyl groups, fused-heterocyclyl groups, and spiro-heterocyclyl groups. A heterocyclyl may be a single ring or multiple rings wherein the multiple rings may be fused, bridged, or spiro. Any non-aromatic ring containing at least one heteroatom is considered a heterocyclyl, regardless of the attachment (i.e., can be bound through a carbon atom or a heteroatom). Further, the term heterocyclyl is intended to encompass any non-aromatic ring containing at least one heteroatom, which ring may be fused to an aryl or heteroaryl ring, regardless of the attachment to the remainder of the molecule. As used herein, heterocyclyl has 2 to 20 ring atoms (i.e. , 4-20 membered heterocyclyl), 2 to ring atoms (i.e. , 4-12 membered heterocyclyl), 4 to 10 ring atoms (i.e., 4-10 membered
heterocyclyl), 4 to 8 ring atoms (i.e. , 4-8 membered heterocyclyl), or 4 to 6 ring carbon atoms (i.e. , 4-6 membered heterocyclyl); having 1 to 5 ring heteroatoms, 1 to 4 ring heteroatoms, 1 to 3 ring heteroatoms, 1 to 2 ring heteroatoms, or 1 ring heteroatom independently selected from nitrogen, sulfur or oxygen. A heterocyclyl may contain one or more oxo and/or thioxo groups. Examples of heterocyclyl groups include
pyrrolidinyl, piperidinyl, piperazinyl, oxetanyl, dioxolanyl, azetidinyl, azetidinyl, morpholinyl, thiomorpholinyl, 4-7 membered sultam, 4-7 membered cyclic carbamate, 4- 7 membered cyclic carbonate, 4-7 membered cyclic sulfide and morpholinyl. As used herein, the term "bridged- heterocyclyl" refers to a four- to ten-membered cyclic moiety connected at two non-adjacent atoms of the heterocyclyl with one or more (e.g. 1 or 2) four- to ten-membered cyclic moiety having at least one heteroatom where each heteroatom is independently selected from nitrogen, oxygen, and sulfur. As used herein, bridged- heterocyclyl includes bicyclic and tricyclic ring systems. Also used herein, the term "spiro-heterocyclyl" refers to a ring system in which a three- to ten-membered heterocyclyl has one or more additional ring, wherein the one or more additional ring is three- to ten-membered cycloalkyl or three- to ten-membered heterocyclyl, where a single atom of the one or more additional ring is also an atom of the three- to ten- membered heterocyclyl. Examples of the spiro-heterocyclyl rings include bicyclic and tricyclic ring systems, such as 2-oxa-7-azaspiro[3.5]nonanyl, 2-oxa-6- azaspiro[3.4]octanyl, and 6-oxa-l-azaspiro[3.3]heptanyl. Examples of the fused- heterocyclyl rings include, but are not limited to, 1,2,3, 4-tetrahydroisoquinolinyl, 1-oxo- 1,2,3,4-tetrahydroisoquinolinyl, l-oxo-l,2-dihydroisoquinolinyl, 4,5,6,7- tetrahydrothieno[2,3-c]pyridinyl, indolinyl, and isoindolinyl, where the heterocyclyl can be bound via either ring of the fused system. As used herein, a bicyclic heterocyclyl group is a heterocyclyl group attached at two points to another cyclic group, wherein the other cyclic group may itself be a heterocyclic group, or a carbocyclic group.
As used herein, the term "nitrogen or sulfur containing heterocyclyl" means a heterocyclyl moiety that contains at least one nitrogen atom or at least one sulfur atom, or both a nitrogen atom and a sulfur atom within the ring structure. It is to be understood that other heteroatoms, including oxygen, may be present in addition to the nitrogen, sulfur, or combinations thereof. Examples of nitrogen or sulfur containing heterocyclyls include morpholinyl, thiomorpholinyl, thiazolyl, isothiazolyl, oxazolidinone 1,2 dithiolyl, piperidinyl, piperazinyl, and the like.
"Hydroxy" or "hydroxyl" refers to the group -OH. "Hydroxyalkyl" refers to an unbranched or branched alkyl group as defined above, wherein one or more hydrogen atoms are replaced by a hydroxyl.
"Nitro" refers to the group -NO2. "Sulfonyl" refers to the group -S(0)2R, where R is a substituent, or a defined group. "Alkylsulfonyl" refers to the group -S(0)2R, where R is a substituent, or a defined group.
"Alkylsulfinyl" refers to the group -S(0)R, where R is a substituent, or a defined group. "Thiocyanate" -SCN.
"Thiol" refers to the group -SR, where R is a substituent, or a defined group. "Thioxo" or "thione" refer to the group (=S) or (S).
Certain commonly used alternative chemical names may be used. For example, a divalent group such as a divalent "alkyl" group, a divalent "aryl" group, etc., may also be referred to as an "alkylene" group or an "alkylenyl" group, an "arylene" group or an "arylenyl" group, respectively. Also, unless indicated explicitly otherwise, where combinations of groups are referred to herein as one moiety, e.g. arylalkyl, the last mentioned group contains the atom by which the moiety is attached to the rest of the molecule. The terms "optional" or "optionally" means that the subsequently described event or circumstance may or may not occur, and that the description includes instances where said event or circumstance occurs and instances in which it does not. Also, the term "optionally substituted" refers to any one or more hydrogen atoms on the designated atom or group may or may not be replaced by a moiety other than hydrogen. "Optionally substituted" may be zero to the maximum number of possible substitutions, and each occurance is independent. When the term "substituted" is used, then that substitution is required to be made at a substitutable hydrogen atom of the indicated substituent. An optional substitution may be the same or different from a (required) substitution.
When a moiety is "optionally substituted," and reference is made to a general term, such as any "alkyl," "alkenyl," "alkynyl," "haloalkyl," "cycloalkyl," "aryl'Or
"heteroaryl," then the general term can refer to any antecedent specifically recited term, such as (Ci-3 alkyl), (C4-6 alkyl), -0(Ci_4 alkyl), (C3-10 cycloalkyl), 0-(C3_io cycloalkyl) and the like. For example, "any aryl" includes both "aryl" and "-O(aryl) as well as examples of aryl, such as phenyl or naphthyl and the like. Also, the term "any heterocyclyl" includes both the terms "heterocyclyl" and O-(heterocyclyl)," as well as examples of heterocyclyls, such as oxetanyl, tetrahydropyranyl, morpholino, piperidinyl and the like. In the same manner, the term "any heteroaryl" includes the terms
"heteroaryl" and "O-(heteroryl)," as well as specific heteroaryls, such as pyridine and the like.
Some of the compounds exist as tautomers. Tautomers are in equilibrium with one another. For example, amide containing compounds may exist in equilibrium with imidic acid tautomers. Regardless of which tautomer is shown, and regardless of the nature of the equilibrium among tautomers, the compounds are understood by one of ordinary skill in the art to comprise both amide and imidic acid tautomers. Thus, the amide containing compounds are understood to include their imidic acid tautomers. Likewise, the imidic acid containing compounds are understood to include their amide tautomers.
Any formula or structure given herein, is also intended to represent unlabeled forms as well as isotopically labeled forms of the compounds. Isotopically labeled compounds have structures depicted by the formulas given herein except that one or more atoms are replaced by an atom having a selected atomic mass or mass
number. Examples of isotopes that can be incorporated into compounds of the disclosure include isotopes of hydrogen, carbon, nitrogen, oxygen, phosphorous, fluorine and chlorine, such as, but not limited to 2H (deuterium, D), 3H (tritium), nC, 13C, 14C, 15N,
18 F, 31 P, 32 P, 35 S, 36 Cl and 125 I. Various isotopically labeled compounds of the present disclosure, for example those into which radioactive isotopes such as 3H, 13C and 14C are incorporated. Such isotopically labelled compounds may be useful in metabolic studies, reaction kinetic studies, detection or imaging techniques, such as positron emission tomography (PET) or single-photon emission computed tomography (SPECT) including drug or substrate tissue distribution assays or in radioactive treatment of patients.
The disclosure also includes "deuterated analogues" of compounds of Formula I in which from 1 to n hydrogens attached to a carbon atom is/are replaced by deuterium, in which n is the number of hydrogens in the molecule. Such compounds exhibit increased resistance to metabolism and are thus useful for increasing the half-life of any compound of Formula I when administered to a mammal, particularly a human. See, for example, Foster, "Deuterium Isotope Effects in Studies of Drug Metabolism," Trends Pharmacol. Sci. 5(12):524-527 (1984). Such compounds are synthesized by means well known in the art, for example by employing starting materials in which one or more hydrogens have been replaced by deuterium.
Deuterium labelled or substituted therapeutic compounds of the disclosure may have improved DMPK (drug metabolism and pharmacokinetics) properties, relating to distribution, metabolism and excretion (ADME). Substitution with heavier isotopes such as deuterium may afford certain therapeutic advantages resulting from greater metabolic stability, for example increased in vivo half-life, reduced dosage requirements and/or an improvement in therapeutic index. An 18F labeled compound may be useful for PET or SPECT studies. Isotopically labeled compounds of this disclosure and prodrugs thereof can generally be prepared by carrying out the procedures disclosed in the schemes or in the examples and preparations described below by substituting a readily available isotopically labeled reagent for a non-isotopically labeled reagent. It is understood that deuterium in this context is regarded as a substituent in the compound of Formula I. The concentration of such a heavier isotope, specifically deuterium, may be defined by an isotopic enrichment factor. In the compounds of this disclosure any atom not specifically designated as a particular isotope is meant to represent any stable isotope of that atom. Unless otherwise stated, when a position is designated specifically as "H" or "hydrogen", the position is understood to have hydrogen at its natural abundance isotopic composition. Accordingly, in the compounds of this disclosure any atom specifically designated as a deuterium (D) is meant to represent deuterium.
In many cases, the compounds of this disclosure are capable of forming acid and/or base salts by virtue of the presence of amino and/or carboxyl groups or groups similar thereto. Provided are also pharmaceutically acceptable salts, hydrates, solvates, tautomeric forms, polymorphs, and prodrugs of the compounds described herein.
"Pharmaceutically acceptable" or "physiologically acceptable" refer to compounds, salts, compositions, dosage forms and other materials which are useful in preparing a pharmaceutical composition that is suitable for veterinary or human pharmaceutical use. The term "pharmaceutically acceptable salt" of a given compound refers to salts that retain the biological effectiveness and properties of the given compound, and which are not biologically or otherwise undesirable. "Pharmaceutically acceptable salts" or "physiologically acceptable salts" include, for example, salts with inorganic acids and salts with an organic acid. In addition, if the compounds described herein are obtained as an acid addition salt, the free base can be obtained by basifying a solution of the acid salt. Conversely, if the product is a free base, an addition salt, particularly a
pharmaceutically acceptable addition salt, may be produced by dissolving the free base in a suitable organic solvent and treating the solution with an acid, in accordance with conventional procedures for preparing acid addition salts from base compounds. Those skilled in the art will recognize various synthetic methodologies that may be used to prepare nontoxic pharmaceutically acceptable addition salts. Pharmaceutically acceptable acid addition salts may be prepared from inorganic and organic acids. Salts derived from inorganic acids include hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like. Salts derived from organic acids include acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, malic acid, malonic acid, succinic acid, maleic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluene-sulfonic acid, salicylic acid, and the like. Likewise, pharmaceutically acceptable base addition salts can be prepared from inorganic and organic bases. Salts derived from inorganic bases include, by way of example only, sodium, potassium, lithium, ammonium, calcium and magnesium salts. Salts derived from organic bases include, but are not limited to, salts of primary, secondary and tertiary amines, such as alkyl amines (i.e., NH2(alkyl)), dialkyl amines (i.e., HN(alkyl)2), trialkyl amines (i.e., N(alkyl)3), substituted alkyl amines (i.e., NH2(substituted alkyl)), di(substituted alkyl) amines (i.e., HN(substituted alkyl)2), tri(substituted alkyl) amines (i.e., N(substituted alkyl)3), alkenyl amines (i.e., NH2(alkenyl)), dialkenyl amines (i.e., HN(alkenyl)2), trialkenyl amines (i.e.,
N(alkenyl)s), substituted alkenyl amines (i.e., NH2(substituted alkenyl)), di(substituted alkenyl) amines (i.e., HN(substituted alkenyl^), tri(substituted alkenyl) amines (i.e., N(substituted alkenyl^, mono-, di- or tri- cycloalkyl amines (i.e., NH2(cycloalkyl), HN(cycloalkyl)2, N(cycloalkyl)3), mono-, di- or tri- arylamines (i.e., NH2(aryl),
HN(aryl)2, N(aryl)3), or mixed amines, etc. Specific examples of suitable amines include, by way of example only, isopropylamine, trimethyl amine, diethyl amine, tri(iso-propyl) amine, tri(n-propyl) amine, ethanolamine, 2-dimethylaminoethanol, piperazine, piperidine, morpholine, N-ethylpiperidine, and the like. The term "substituted" means that any one or more hydrogen atoms on the designated atom or group is replaced with one or more substituents other than hydrogen, provided that the designated atom's normal valence is not exceeded. The one or more substituents include, but are not limited to, alkyl, alkenyl, alkynyl, alkoxy, acyl, amino, amido, amidino, aryl, azido, carbamoyl, carboxyl, carboxyl ester, cyano, guanidino, halo, haloalkyl, haloalkoxy, heteroalkyl, heteroaryl, heterocyclyl, hydroxy, hydrazino, imino, oxo, nitro, alkylsulfinyl, sulfonic acid, alkylsulfonyl, thiocyanate, thiol, thione, or combinations thereof. Polymers or similar indefinite structures arrived at by defining substituents with further substituents appended ad infinitum (e.g., a substituted aryl having a substituted alkyl which is itself substituted with a substituted aryl group, which is further substituted by a substituted heteroalkyl group, etc.) are not intended for inclusion herein. Unless otherwise noted, the maximum number of serial substitutions in compounds described herein is three. For example, serial substitutions of substituted aryl groups with two other substituted aryl groups are limited to ((substituted aryl)substituted aryl) substituted aryl. Similarly, the above definitions are not intended to include impermissible substitution patterns (e.g., methyl substituted with 5 fluorines or heteroaryl groups having two adjacent oxygen ring atoms). Such impermissible substitution patterns are well known to the skilled artisan. When used to modify a chemical group, the term "substituted" may describe other chemical groups defined herein. Unless specified otherwise, where a group is described as optionally substituted, any substituents of the group are themselves unsubstituted. For example, in some embodiments, the term "substituted alkyl" refers to an alkyl group having one or more substituents including hydroxyl, halo, alkoxy, cycloalkyl, heterocyclyl, aryl, and heteroaryl. In other embodiments, the one or more substituents may be further substituted with halo, alkyl, haloalkyl, hydroxyl, alkoxy, cycloalkyl, heterocyclyl, aryl, or heteroaryl, each of which is substituted. In other embodiments, the substituents may be further substituted with halo, alkyl, haloalkyl, alkoxy, hydroxyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, each of which is unsubstituted One skilled in the art will recognize that substituents and other moieties of the compounds of the generic formula herein should be selected in order to provide a compound which is sufficiently stable to provide a pharmaceutically useful compound which can be formulated into an acceptably stable pharmaceutical composition. Compounds which have such stability are contemplated as falling within the scope of the present invention. It should be understood by one skilled in the art that any combination of the definitions and substituents described above should not result in an inoperable species or compound.
As used herein, "pharmaceutically acceptable carrier" or "pharmaceutically acceptable excipient" includes any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents and the like. The use of such media and agents for pharmaceutically active substances is well known in the art. Except insofar as any conventional media or agent is incompatible with the active ingredient, its use in the therapeutic compositions is contemplated.
Supplementary active ingredients can also be incorporated into the compositions.
As used herein, "pharmaceutically acceptable carrier" or "pharmaceutically acceptable excipient" includes any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents and the like. The use of such media and agents for pharmaceutically active substances is well known in the art. Except insofar as any conventional media or agent is incompatible with the active ingredient, its use in the therapeutic compositions is contemplated.
Supplementary active ingredients can also be incorporated into the compositions.
A "solvate" is formed by the interaction of a solvent and a compound. Solvates of salts of the compounds described herein are also provided. Hydrates of the compounds described herein are also provided.
Combinations
Patients being treated by administration of the IRAK4 inhibitors of the disclosure often exhibit diseases or conditions that benefit from treatment with other therapeutic agents. These diseases or conditions can be of an inflammatory nature or can be related to cancer, metabolic disorders, gastrointestinal disorders and the like. Thus, one aspect of the disclosure is a method of treating an inflammation related disease or condition, or a metabolic disorder, gastrointestinal disorder, or cancer and the like comprising administering a compound of the in combination with one or more compounds useful for the treatment of such diseases to a subject, particularly a human subject, in need thereof. In some embodiments, a compound of the present disclosure is co-formulated with the additional one or more active ingredients. In some embodiments, the other active ingredient is administered at approximately the same time, in a separate dosage form. In some embodiments, the other active ingredient is administered sequentially, and may be administered at different times in relation to a compound of the present disclosure.
Combinations for Inflammatory Diseases and Conditions
For example, a compound of the present disclosure may be combined with one or more 5 -Lipoxygenase inhibitors, Acetylcholinesterase inhibitors, ACTH receptor agonists, Activin receptor antagonists, Acyltransferase inhibitors, Adrenocorticotrophic hormone ligands, AKT1 gene inhibitors, Alkaline phosphatase modulators, Alkaline phosphatase stimulators, Androgen receptor agonists, Apolipoprotein C3 antagonists, Bactericidal permeability protein stimulators, Beta adrenoceptor antagonists, Beta- glucuronidase inhibitors, B-lymphocyte antigen CD20 inhibitors, Bradykinin receptor modulators, BTK kinase inhibitors, Calcineurin inhibitors, Calcium channel inhibitors, Cannabinoid CB1 receptor modulators, Cannabinoid CB2 receptor modulators, Cannabinoid receptor antagonists, Cannabinoid receptor modulators, Cathepsin S inhibitors, CCN protein stimulators, CCR3 chemokine antagonists, CCR5 chemokine antagonists, CCR9 chemokine antagonists, CD3 modulators, CD40 ligand inhibitors, CD40 ligand receptor antagonists, CD49b antagonists, CD49d antagonists, CD89 agonists, Cell adhesion molecule inhibitors, Chemokine CXC ligand inhibitors, CHST 15 gene inhibitors, Collagen modulators, CSF-1 agonists, CSF-1 antagonists, CXC10 chemokine ligand inhibitors, CXCR2 chemokine antagonists, Cyclic GMP phosphodiesterase inhibitors, Cyclooxygenase 2 inhibitors, Cyclooxygenase inhibitors, Cyclooxygenase stimulators, Cytochrome P450 3A4 inhibitors, Cytotoxic T- lymphocyte protein-4 stimulators, Dihydroceramide delta 4 desaturase inhibitors, Dihydroorotate dehydrogenase inhibitors, DNA polymerase inhibitors, EGFR family tyrosine kinase receptor modulators, Eosinophil peroxidase inhibitors, Eotaxin ligand inhibitors, EP4 prostanoid receptor agonists, Epidermal growth factor agonists,
Epidermal growth factor ligands, Estrogen receptor beta agonists, Factor XIII agonists, FGF- 10 ligands, FGF2 receptor agonists, Fractalkine ligand inhibitors, Free fatty acid receptor 2 antagonists, GATA 3 transcription factor inhibitors, Glucagon-like peptide 2 agonists, Glucocorticoid agonists, GM-CSF receptor agonists, G-protein coupled receptor 84 antagonists, Guanylate cyclase receptor agonists, Histamine H2 receptor antagonists, Histone acetyltransferase inhibitors, Histone deacetylase inhibitors, HLA class II antigen modulators, Hydrolase inhibitors, ICAM1 gene inhibitors, ICAM-1 inhibitors, IL1 gene inhibitors, IL- 10 agonists, IL10 gene stimulators, IL-11 agonists, IL- 12 antagonists, IL 12 gene inhibitors, IL- 13 antagonists, IL- 17 antagonists, IL-2 antagonists, IL-2 receptor alpha subunit inhibitors, IL-21 antagonists, IL-23 antagonists, IL-6 antagonists, IL6 gene inhibitors, IL-6 receptor modulators, IL-7 antagonists, IL-8 antagonists, Immunoglobulin Gl agonists, Immunoglobulin G2 modulators, Inosine monophosphate dehydrogenase inhibitors, Insulin sensitizers, Integrin alpha-4/beta-l antagonists, Integrin alpha-4/beta-7 antagonists, Integrin alpha- E antagonists, Integrin antagonists, Integrin beta-7 antagonists, Interferon beta ligands, Interleukin 17E ligand inhibitors, Interleukin ligand inhibitors, Interleukin receptor 17A antagonists, Interleukin receptor 17B antagonists, Interleukin- 1 beta ligands,
Interleukin- 1 beta ligand modulators, Interleukin-6 ligand inhibitors, JAK tyrosine kinase inhibitors, Jakl tyrosine kinase inhibitors, JAK2 gene inhibitors, Jak3 tyrosine kinase inhibitors, Jun N terminal kinase inhibitors, LanC like protein 2 modulators, Leukotriene BLT receptor antagonists, Lipoxygenase modulators, L-Selectin antagonists, MAdCAM inhibitors, Matrix metalloprotease inhibitors, Matrix metalloprotease modulators, Melanocortin agonists, Membrane copper amine oxidase inhibitors, Metalloprotease-2 inhibitors, Metalloprotease-9 inhibitors, MIP 3 alpha ligand inhibitors, Mitochondrial 10 kDa heat shock protein stimulators, Monocyte differentiation antigen CD 14 inhibitors, mTOR inhibitors, Mucin stimulators, NAD- dependent deacetylase sirtuin-1 stimulators, Natriuretic peptide receptor C agonists,
Neuregulin-4 ligands, Nicotinic acetylcholine receptor agonists, Nicotinic ACh receptor alpha 4 subunit modulators, Nicotinic ACh receptor alpha 7 subunit stimulators, Nicotinic ACh receptor beta 2 subunit modulators, NK1 receptor antagonists, NKG2 D activating NK receptor antagonists, Nuclear factor kappa B inhibitors, Opioid growth factor receptor agonists, Opioid receptor antagonists, Opioid receptor delta antagonists, Oxidoreductase inhibitors, P2X7 purinoceptor agonists, p38 MAP kinase inhibitors, PARP inhibitors, PDE 4 inhibitors, PDGF receptor agonists, Phagocytosis stimulating peptide modulators, Phospho MurNAc pentapeptide transferase inhibitors,
Phospholipase A2 inhibitors, Platelet activating factor receptor antagonists, Potassium channel inhibitors, PPAR alpha agonists, PPAR delta agonists, PPAR gamma agonists, Protein CYR61 stimulators, Protein fimH inhibitors, Protein kinase C alpha inhibitors, Protein kinase C beta inhibitors, Protein kinase C delta inhibitors, Protein kinase C epsilon inhibitors, Protein kinase C eta inhibitors, Protein kinase C theta inhibitors, Protein kinase G inhibitors, Protein kinase inhibitors, P-selectin glycoprotein ligand- 1 inhibitors, PurH purine biosynthesis protein inhibitors, Retinoic acid receptor alpha agonists, Retinoic acid receptor beta agonists, Retinoid receptor agonists, RNA polymerase inhibitors, SMAD-7 inhibitors, Sodium channel inhibitors, Somatostatin receptor agonists, Sphingosine 1 phosphate phosphatase 1 stimulators, Sphingosine 1 phosphate phosphatase modulators, Sphingosine kinase 1 inhibitors, Sphingosine kinase 2 inhibitors, Sphingosine- 1 -phosphate receptor- 1 agonists, Sphingosine- 1 -phosphate receptor- 1 antagonists, Sphingosine- 1 -phosphate receptor- 1 modulators, Sphingosine- 1- phosphate receptor-5 modulators, STAT3 gene inhibitors, STAT-3 inhibitors, STAT-4 inhibitors, Stem cell antigen- 1 inhibitors, Superoxide dismutase modulators,
Superoxide dismutase stimulators, SYK kinase inhibitors, T cell surface glycoprotein CD28 inhibitors, TGF beta 1 ligand inhibitors, Thymulin agonists, TLR-2 antagonists, TLR-4 antagonists, TLR-9 agonists, TNF alpha ligand inhibitors, TNF alpha ligand modulators, TNF antagonists, TPL2 kinase inhibitors, Trefoil factor modulators, Tryptase inhibitors, Tryptophan 5-hydroxylase inhibitors, Tumor necrosis factor 14 ligand modulators, TYK2 kinase inhibitors, Type I TNF receptor antagonists, Type II TNF receptor modulators, Unspecified growth factor receptor modulators, Vanilloid VR1 agonists, Vitamin D3 receptor agonists, Zonulin inhibitors, abatacept; acemannan; adalimumab; DCCT-10; apremilast; AST- 120; balsalazide; balsalazide sodium ;
basiliximab; beclomethasone dipropionate; budesonide; D-9421; budesonide MMX; catridecacog; certolizumab pegol; Clostridium butyricum; etanercept; fingolimod;
glatiramer acetate; golimumab; infliximab; infliximab biosimilar; infliximab follow-on biologic; interferon beta-la, Biogen; lenalidomide; mesalazine ; GED-0001; AJG-501; metenkefalin acetate with tridecactide acetat, mycophenolate mofetil; naltrexone;
natalizumab; nitazoxanide; olsalazine; oprelvekin; propionyl-L-carnitine; recombinant interferon beta- la, Serono; remestemcel-L; rifaximin; rituximab; ropivacaine;
rosiglitazone; sargramostim; secukinumab; SPD-480; tacrolimus; tamibarotene;
teduglutide; thalidomide; tocilizumab ; RO-4877533; tofacitinib ; CP-690550; Trichuris suis ova; ASP-1002; ustekinumab; valganciclovir; vedolizumab; zileuton; anti-CD3 imaging agent (antibody fragment, cancer/autoimmune disease), ImaginAb; AVX-470; ciclosporin; CXCRl/2 ligands mAb (immunology), Eli Lilly; FFP-102; GSK-3050002;
INN- 108; IR-777; SGM-1019; peg-ilodecakin; PF-06480605; PF-06651600; SER-287;
Syn-1002; Thetanix; tolerogenic dendritic cell therapy (injectable, Crohns disease),
Hospital Clinic of Barcelona/Fundacio Clinic; TOP-1288; VBY-036; VBY-129; 946414- 98-8; BMS-936557; 99mTc-annexin V-128; ABC-294640; abrilumab; Alequel; AMG-
139; amiselimod; APD-334; ASP-3291; beclomethasone dipropionate; bertilimumab; ciclosporin; clazakizumab; DLX-105; dolcanatide; E-6011; ETX-201; FFP-104;
filgotinib; foralumab; GED-0507-34-Levo; givinostat; GLPG-0974; GLPG-1205;
iberogast N (ulcerative colitis), Bayer; BAY98-7410; INV-103; JNJ-40346527; K(D)PT; KAG-308; KHK-4083; KRP-203; larazotide acetate; CB-01-05-MMX; LY-3074828; mesalamine with N-acetylcysteine ; midismase; molgramostim follow on biologic with fosfomycin with carbapenem (intraintestinal, Crohn's disease), Reponex; multipotent adult progenitor cell therapy (ischemia/cerebral palsy), Athersys/ Healios; NN-8828; olokizumab; OvaSave; P-28-GST; PDA-002; PF-4236921; PF-547659; prednisolone; PUR-0110; QBECO; RBX-2660; repurposed naltrexone (low dose, liver disease, Crohn's disease), TaiwanJ; JKB-122; SB-012; sotrastaurin; STNM-01; TAK-114; tetomilast;
Debio-0512; TRK-170; TRX-318; vatelizumab; VB-201; ZP-1848; zucapsaicin ; ABT-
494; alicaforsen; Ampion; BI-655066; briakinumab; cannabidiol; carotegast methyl; cobitolimod; dexamethasone sodium phosphate; elafibranor; etrolizumab; GS-5745; HMPL-004; LP-02; mesalazine; metronidazole mongersen; ocrelizumab; ozanimod; peficitinib; RHB-104; rifaximin ; tildrakizumab; tralokinumab; brodalumab; laquinimod; plecanatide; telotristat etiprate; infliximab biosimilar, Samsung Bioepis; AZD-058;and rifabutin with clarithromycin and further with clofazimine.
Also, the following non-exhaustive list of classes of compounds and compounds may be combined with a compound of the present disclosure: 5 -Lipoxygenase inhibitors, such as zileuton, etalocibm FPL-64170, E-3040, and BU-4601A; Acetylcholinesterase inhibitors, such as BL-7040; ACTH receptor agonists, such as metenkefalin acetate with tridecactide acetate, and FAR-404; Activin receptor antagonists such as follistatin; Acyltransferase inhibitors such as AZD-0585; Adrenocorticotrophic hormone ligands, such as metenkefalin acetate with tridecactide acetate, and FAR-404; AKT1 gene inhibitors, such as vidofludimus; Alkaline phosphatase modulators such as
recombinant human alkaline phosphatase (oral, ulcerative colitis), AM-Pharma; Alkaline phosphatase stimulators such as bovine alkaline phosphatase; Androgen receptor agonists, such as PB-005; Apolipoprotein C3 antagonists, such as AZD-0585;
Bactericidal permeability protein stimulators, such as opebacan; Beta adrenoceptor antagonists, such as NM-001; Beta-glucuronidase inhibitors, such as KD-018; B- lymphocyte antigen CD20 inhibitors, such as ocrelizumab, rituximab; Bradykinin receptor modulators, such as givinostat; Calcineurin inhibitors, such as tacrolimus, ciclosporin; Calcium channel inhibitors, such as clotrimazole; Cannabinoid CBl receptor modulators, such as GWP42003-P, cannabidiol; Cannabinoid CB2 receptor modulators, such as GWP42003-P, cannabidiol; Cannabinoid receptor antagonists, such as fingolimod; Cannabinoid receptor modulators, such as GWP42003-P, cannabidiol; Cathepsin S inhibitors, such as VBY-129, VBY-036; CCN protein stimulators, such as CSA-13; CCR3 chemokine antagonists, such as bertilimumab; CCR5 chemokine antagonists, such as HGS-1025; CCR9 chemokine antagonists, such as MLN-3126, vercirnon, CCX-025 ; CD3 modulators, such as visilizumab; CD40 ligand inhibitors, such as FFP-104; CD40 ligand receptor antagonists, such as FFP-104, FFP-102, toralizumab; CD49b antagonists, such as vatelizumab; CD49d antagonists, such as
ELND-004; CD89 agonists, such as HF-1020; Cell adhesion molecule inhibitors, such as natalizumab, alicaforsen (intravenous), ASP- 2002, ISIS-2302; Chemokine CXC ligand inhibitors, such as CXCRl/2 ligands mAb (immunology), Eli Lilly; CHST15 gene inhibitors, such as STNM-01; Collagen modulators, such as adipose-derived stem cell therapy (Celution System), Cytori, DCCT-10; CSF-1 agonists, such as sargramostim, molgramostim follow on biologic with fosfomycin with carbapenem (intraintestinal, Crohn's disease), Reponex; CSF-1 antagonists, such as JNJ-40346527; CXC 10 chemokine ligand inhibitors, such as 946414-98-8, BMS-936557; CXCR2 chemokine antagonists, such as elubrixin; Cyclic GMP phosphodiesterase inhibitors, such as CEL- 031; Cyclooxygenase 2 inhibitors, such as P-54; Cyclooxygenase inhibitors, such as mesalazine, 4-aminosalicylate sodium, AJG-501, AGI-022; Cyclooxygenase stimulators, such as nicotine polacrilex; Cytochrome P450 3A4 inhibitors, such as KD-018;
Cytotoxic T-lymphocyte protein-4 stimulators, such as abatacept; Dihydroceramide delta 4 desaturase inhibitors, such as ABC-294640; Dihydroorotate dehydrogenase inhibitors, such as vidofludimus ; DNA polymerase inhibitors, such as valganciclovir; EGFR family tyrosine kinase receptor modulators, such as neuregulin 4 (Crohn's
disease/ulcerative colitis/necrotizing enterocolitis), Avexegen Therapeutics/Children's Hospital of Los Angeles; Eosinophil peroxidase inhibitors, such as AWEPOPD-01, AWEPO-003; Eotaxin ligand inhibitors, such as bertilimumab; EP4 prostanoid receptor agonists, such as KAG-308; Epidermal growth factor agonists, such as heparin-EGF-like factor, Scios Nova; Epidermal growth factor ligands, such as Hebervis; Estrogen receptor beta agonists, such as prinaberel; Factor XIII agonists, such as catridecacog; FGF-10 ligands, such as repifermin; FGF2 receptor agonists, such as F2A; Fractalkine ligand inhibitors, such as E-6011; Free fatty acid receptor 2 antagonists, such as GLPG-0974; GATA 3 transcription factor inhibitors, such as SB-012; Glucagon-like peptide 2 agonists, such as teduglutide, ZP-1848, NB-1002; Glucocorticoid agonists, such as budesonide, beclomethasone dipropionate, dexamethasone sodium phosphate, AJG-511, DOR- 201, D-9421-C; GM-CSF receptor agonists, such as sargramostim, molgramostim follow on biologic with fosfomycin with carbapenem (intraintestinal, Crohn's disease), Reponex; G-protein coupled receptor 84 antagonists, such as GLPG-1205; Guanylate cyclase receptor agonists, such as dolcanatide, SP-333; Histamine H2 receptor antagonists, such as bismuth, Medeva; Histone acetyltransferase inhibitors, such as TIP60 inhibitors (ulcerative colitis/inflammatory bowel disease/autoimmune diseases), University of Pennsylvania; Histone deacetylase inhibitors, such as givinostat; HLA class II antigen modulators, such as HLA class II protein modulators (Crohns disease), Nextera AS; Hydrolase inhibitors, such as SC-56938; ICAM1 gene inhibitors, such as alicaforsen; ICAM-1 inhibitors, such as alicaforsen (intravenous), ISIS-2302; IL1 gene inhibitors, such as PLR-14; IL-10 agonists, such as peg-ilodecakin, AM-0010; IL10 gene stimulators, such as gene therapy (IL-10), Imperial College; IL-11 agonists, such as oprelvekin, YM-294; IL-12 antagonists, such as ustekinumab, briakinumab, apilimod; IL12 gene inhibitors, such as RDP-58; IL-13 antagonists, such as tralokinumab, anrukinzumab; IL-17 antagonists, such as secukinumab, vidofludimus; IL-2 antagonists, such as daclizumab; IL-2 receptor alpha subunit inhibitors, such as basiliximab, daclizumab, BSX-003, Ro-34-7375; IL-21 antagonists, such as NN-8828, ATR-107; IL- 23 antagonists, such as tildrakizumab, ustekinumab, BI-655066, AMG-139,
briakinumab, LY-3074828, apilimod; IL-6 antagonists, such as tocilizumab,
clazakizumab, olokizumab, HMPL-004, AMG-220, FM-101; IL6 gene inhibitors, such as YSIL6-T-PS; IL-6 receptor modulators, such as tocilizumab; IL-7 antagonists, such as interleukin-7 receptor modulators (ulcerative colitis / T-cell acute lymphoblastic leukaemia), Effimune; IL-8 antagonists, such as elubrixin, clotrimazole; Immunoglobulin Gl agonists, such as HF-1020; Immunoglobulin G2 modulators, such as PF-547659; Inosine monophosphate dehydrogenase inhibitors, such as mycophenolate mofetil;
Insulin sensitizers, such as elafibranor, rosiglitazone, HE-3286, EGS-21; Integrin alpha- 4/beta-l antagonists, such as natalizumab, TRK-170, firategrast; Integrin alpha-4/beta-7 antagonists, such as etrolizumab, vedolizumab, abrilumab, carotegast methyl, TRK-170, firategrast; Integrin alpha-E antagonists, such as etrolizumab; Integrin antagonists, such as vatelizumab, ASP- 2002; Integrin beta-7 antagonists, such as etrolizumab; Interferon beta ligands, such as interferon beta-la, recombinant interferon beta-la, Serono;
Interleukin 17E ligand inhibitors, such as anti-IL-17BR humanized antibody (lung fibrosis/asthma/ulcerative colitis), Medical Research Council Technology; Interleukin ligand inhibitors, such as HE-3286; Interleukin receptor 17A antagonists, such as brodalumab; Interleukin receptor 17B antagonists, such as anti-IL-17BR humanized antibody (lung fibrosis/asthma/ulcerative colitis), Medical Research Council
Technology; Interleukin- 1 beta ligands, such as K(D)PT, PUR-0110, HMPL-004;
Interleukin- 1 beta ligand modulators, such as PUR-0110, HMPL-004; Interleukin-6 ligand inhibitors, such as PF-4236921; JAK tyrosine kinase inhibitors, such as tofacitinib, peficitinib; Jakl tyrosine kinase inhibitors, such as ABT-494, tofacitinib, filgotinib, peficitinib, GLPG-0555, solcitinib; JAK2 gene inhibitors, such as vidofludimus; Jak3 tyrosine kinase inhibitors, such as tofacitinib, peficitinib; Jun N terminal kinase inhibitors, such as semapimod; LanC like protein 2 modulators, such as BT-11; Leukotriene BLT receptor antagonists, such as ONO-4057, etalocib, SC-53228, SC-52798; Lipoxygenase modulators, such as mesalazine; L-Selectin antagonists, such as BNP-001; MAdCAM inhibitors, such as vedolizumab, PF-547659; Matrix metalloprotease inhibitors, such as D-5410; Matrix metalloprotease modulators, such as D-5410; Melanocortin agonists, such as ASP-3291; Membrane copper amine oxidase inhibitors, such as vepalimomab; Metalloprotease-2 inhibitors, such as KD-018, RWJ- 68354; Metalloprotease-9 inhibitors, such as GS-5745; MIP 3 alpha ligand inhibitors, such as GSK-3050002; Mitochondrial 10 kDa heat shock protein stimulators, such as INV-103; Monocyte differentiation antigen CD14 inhibitors, such as CD14 antiinflammatory, Cornell; mTOR inhibitors, such as P-2281; Mucin stimulators, such as rebamipide; NAD-dependent deacetylase sirtuin-1 stimulators, such as SRT-2104; Natriuretic peptide receptor C agonists, such as plecanatide; Neuregulin-4 ligands, such as neuregulin 4 (Crohn's disease/ulcerative colitis/necrotizing enterocolitis), Avexegen Therapeutics/Children's Hospital of Los Angeles; Nicotinic acetylcholine receptor agonists, such as TC-2403, nicotine polacrilex, nicotine; Nicotinic ACh receptor alpha 4 subunit modulators, such as TC-2403; Nicotinic ACh receptor alpha 7 subunit stimulators, such as GTS-21; Nicotinic ACh receptor beta 2 subunit modulators, such as TC-2403; NK1 receptor antagonists, such as KD-018, nolpitantium besilate; NKG2 D activating NK receptor antagonists, such as NNC-0142-002; Nuclear factor kappa B inhibitors, such as KD-018, cobitolimod, CSA-13, HE-3286, HMPL-004, Avrina, mesalamine with N-acetylcysteine , P-54; Opioid growth factor receptor agonists, such as metenkefalin acetate with tridecactide acetate, FAR-404; Opioid receptor antagonists, such as naltrexone, IRT-103; Opioid receptor delta antagonists, such as KD-018;
Oxidoreductase inhibitors, such as olsalazine; P2X7 purinoceptor agonists, such as givinostat; p38 MAP kinase inhibitors, such as RDP-58, doramapimod, semapimod, RWJ-68354; PARP inhibitors, such as EB-47, INO-1003; PDE 4 inhibitors, such as apremilast, tetomilast, CC-1088; PDGF receptor agonists, such as oprelvekin, YM-294; Phagocytosis stimulating peptide modulators, such as 99mTc-RP-128; Phospho MurNAc pentapeptide transferase inhibitors, such as SQ-641; Phospholipase A2 inhibitors, such as varespladib methyl; Platelet activating factor receptor antagonists, such as dersalazine sodium; Potassium channel inhibitors, such as clotrimazole; PPAR alpha agonists, such as elafibranor (GFT-1007); PPAR delta agonists, such as elafibranor (GFT-1007); PPAR gamma agonists, such as rosiglitazone, GED-0507-34-Levo, etalocib; Protein CYR61 stimulators, such as CSA-13; Protein fimH inhibitors, such as EB-8018; Protein kinase C alpha inhibitors, such as sotrastaurin (AEB-071); Protein kinase C beta inhibitors, such as sotrastaurin (AEB-071); Protein kinase C delta inhibitors, such as sotrastaurin (AEB- 071); Protein kinase C epsilon inhibitors, such as sotrastaurin (AEB-071); Protein kinase C eta inhibitors, such as sotrastaurin (AEB-071); Protein kinase C theta inhibitors, such as sotrastaurin (AEB-071); Protein kinase G inhibitors, such as CEL-031; Protein kinase inhibitors, such as TOP-1288; P-selectin glycoprotein ligand-1 inhibitors, such as SEL- K2; PurH purine biosynthesis protein inhibitors, such as mycophenolate mofetil;
Retinoic acid receptor alpha agonists, such as tamibarotene; Retinoic acid receptor beta agonists, such as tamibarotene; Retinoid receptor agonists, such as tamibarotene; RNA polymerase inhibitors, such as rifaximin; SMAD-7 inhibitors, such as mongersen (GED- 0301); Sodium channel inhibitors, such as ropivacaine; Somatostatin receptor agonists, such as vapreotide; Sphingosine 1 phosphate phosphatase 1 stimulators, such as APD- 334; Sphingosine 1 phosphate phosphatase modulators, such as SIP modulators (oral, multiple sclerosis/ ulcerative colitis/rheumatoid arthritis), Akaal Pharma; Sphingosine kinase 1 inhibitors, such as ABC-294640; Sphingosine kinase 2 inhibitors, such as ABC- 294640; Sphingosine- 1 -phosphate receptor- 1 agonists, such as ozanimod (RPC-1063), KRP-203; Sphingosine- 1 -phosphate receptor- 1 antagonists, such as amiselimod (MT- 1303); Sphingosine- 1 -phosphate receptor-1 modulators, such as fingolimod (FTY-720), ozanimod (RPC-1063), amiselimod (MT-1303); Sphingosine- 1 -phosphate receptor-5 modulators, such as ozanimod; STAT3 gene inhibitors, such as vidofludimus; STAT-3 inhibitors, such as TAK-114; STAT-4 inhibitors, such as STAT-4 antisense
oligonucleotide (Crohns disease/colitis), AID; Stem cell antigen-1 inhibitors, such as Ampion, DMI-9523; Superoxide dismutase modulators, such as midismase, LT-0011; Superoxide dismutase stimulators, such as superoxide dismutase; T cell surface glycoprotein CD28 inhibitors, such as abatacept; TGF beta 1 ligand inhibitors, such as mongersen, GED-0301; Thymulin agonists, such as Syn-1002; TLR-2 antagonists, such as VB-201; TLR-4 antagonists, such as JKB-122, VB-201; TLR-9 agonists, such as BL- 7040, cobitolimod; TNF alpha ligand inhibitors, such as adalimumab, certolizumab pegol, infliximab biosimilar, infliximab, golimumab, ISIS-104838, CSA-13, DLX-105, adalimumab biosimilar, dersalazine sodium, Debio-0512, HMPL-004, DLX-105, infliximab follow-on biologic, AZD-9773, CYT-020-TNFQb, DOM-0200; TNF alpha ligand modulators, such as PUR-0110, CDP-571; TNF antagonists, such as etanercept, certolizumab pegol, AVX-470, onercept; Trefoil factor modulators, such as AG-012; Tryptase inhibitors, such as APC-2059; Tryptophan 5-hydroxylase inhibitors, such as telotristat etiprate; Tumor necrosis factor 14 ligand modulators, such as SAR-252067; Type I TNF receptor antagonists, such as DOM-0100; Type II TNF receptor modulators, such as etanercept; Unspecified growth factor receptor modulators, such as AP-005; Vanilloid VR1 agonists, such as zucapsaicin; Vitamin D3 receptor agonists, such as calcitriol; and Zonulin inhibitors, such as larazotide acetate, AT-1001.
Also, the following non-exhaustive list of classes of compounds and compounds may be combined with a compound of the present disclosure: 14-3-3 protein eta inhibitors, 5-Lipoxygenase inhibitors, Abl tyrosine kinase inhibitors, ACTH receptor agonists, Adenosine A3 receptor agonists, Adenosine deaminase inhibitors, ADP ribosyl cyclase- 1 modulators, ADP ribosylation factor 6 inhibitors,
Adrenocorticotrophic hormone ligands, Aggrecanase-2 inhibitors, Albumin modulators, API transcription factor inhibitors, Basigin inhibitors, Bcr protein inhibitors, B- lymphocyte antigen CD 19 inhibitors, B -lymphocyte antigen CD20 inhibitors, B- lymphocyte antigen CD20 modulators, B-lymphocyte stimulator ligand inhibitors, Bradykinin receptor modulators, BRAF gene inhibitors, Branched amino acid aminotransferase 1 inhibitors, Bromodomain containing protein inhibitors, Btk tyrosine kinase inhibitors, Cadherin-11 antagonists, Calcineurin inhibitors, Calcium channel inhibitors, Carbonic anhydrase inhibitors, Cathepsin K inhibitors, Cathepsin S inhibitors, CCR1 chemokine antagonists, CCR2 chemokine antagonists, CCR3 gene modulators, CCR5 chemokine antagonists, CD 126 antagonists, CD29 modulators, CD3 modulators, CD39 agonists, CD4 agonists, CD4 antagonists, CD40 ligand inhibitors, CD40 ligand receptor antagonists, CD40 ligand receptor modulators, CD52 antagonists, CD73 agonists, CD79b modulators, CD80 antagonists, CD86 antagonists, CD95 antagonists, Cell adhesion molecule inhibitors, Choline kinase inhibitors, Clusterin stimulators, Complement C5 factor inhibitors, Complement Factor stimulators, C-reactive protein inhibitors, CSF-1 antagonists, CXC 10 chemokine ligand inhibitors, CXCR4 chemokine antagonists, Cyclin-dependent kinase inhibitor 1 inhibitors, Cyclin-dependent kinase-2 inhibitors, Cyclin-dependent kinase-4 inhibitors, Cyclin-dependent kinase-5 inhibitors, Cyclin-dependent kinase-6 inhibitors, Cyclin- dependent kinase-7 inhibitors, Cyclin-dependent kinase-9 inhibitors, Cyclooxygenase 2 inhibitors, Cyclooxygenase 2 modulators, Cyclooxygenase inhibitors, Cytosolic phospholipase A2 inhibitors, Cytotoxic T-lymphocyte protein-4 modulators, Cytotoxic T-lymphocyte protein-4 stimulators, DHFR inhibitors, Diamine acety transferase inhibitors, Dihydroorotate dehydrogenase inhibitors, Elongation factor 2 inhibitors, Eotaxin 2 ligand inhibitors, EP4 prostanoid receptor antagonists, Erythropoietin receptor agonists, Fas ligands, FGF-2 ligand inhibitors, FK506 binding protein- 12 modulators, Folate antagonists, Folate receptor agonists, Folate receptor beta antagonists, Folate receptor modulators, Fractalkine ligand inhibitors, Fyn tyrosine kinase inhibitors, G protein coupled receptor 15 antagonists, GAB A A receptor modulators, Glucocorticoid agonists, Glucocorticoid antagonists, Glucocorticoid induced leucine zipper stimulators, GM-CSF ligand inhibitors, GM-CSF receptor antagonists, GM-CSF receptor modulators, Growth regulated protein alpha ligand inhibitors, Hwith Kwith ATPase inhibitors, Histamine H4 receptor antagonists, Histone deacetylase inhibitors, Histone deacetylase-6 inhibitors, HIV-1 gpl20 protein inhibitors, HLA class II antigen DQ-2 alpha modulators, HLA class II antigen inhibitors, HLA class II antigen modulators, Hsp 70 family inhibitors, Hypoxia inducible factor- 1 inhibitors, IFNB gene stimulators, I-kappa B kinase beta inhibitors, I-kappa B kinase inhibitors, IL-1 antagonists, IL- 10 agonists, IL- 11 agonists, IL-12 antagonists, IL- 15 antagonists, IL- 17 antagonists, IL-17 receptor modulators, IL-2 agonists, IL-2 antagonists, IL-21 antagonists, IL-23 antagonists, IL-3 antagonists, IL- 4 agonists, IL-6 antagonists, IL-6 receptor modulators, Immunoglobulin antagonists, Immunoglobulin Gl agonists, Immunoglobulin Gl antagonists, Immunoglobulin Gl modulators, Immunoglobulin G2 antagonists, Immunoglobulin G2 modulators, Immunoglobulin gamma Fc receptor II modulators, Immunoglobulin gamma Fc receptor IIB antagonists, Immunoglobulin kappa modulators, Immunoglobulin M antagonists, Inducible nitric oxide synthase inhibitors, Inosine monophosphate dehydrogenase inhibitors, Insulin sensitizers, Integrin alpha- 1 /beta- 1 antagonists, Integrin alpha's/beta-! antagonists, Integrin antagonists, Interferon beta ligands, Interferon gamma ligands, Interleukin 17A ligand inhibitors, Interleukin 17F ligand inhibitors, Interleukin 23A inhibitors, Interleukin ligands, Interleukin receptor 17A antagonists, Interleukin- 1 beta ligand inhibitors, Interleukin- 10 ligands, Interleukin-2 ligands, Interleukin-4 ligands, Interleukin-6 ligand inhibitors, Itk tyrosine kinase inhibitors, JAK tyrosine kinase inhibitors, Jakl tyrosine kinase inhibitors, Jak2 tyrosine kinase inhibitors, JAK3 gene inhibitors, Jak3 tyrosine kinase inhibitors, Jun N terminal kinase inhibitors, KCNA voltage-gated potassium channel-3 modulators, Kelch like ECH associated protein 1 modulators, Kit tyrosine kinase inhibitors, LanC like protein 2 modulators, LITAF gene inhibitors, Lymphocyte function antigen-3 receptor antagonists, Lyn tyrosine kinase inhibitors, Macrophage mannose receptor 1 modulators, MAdCAM inhibitors, MAP kinase modulators, MAP3K2 gene inhibitors, MAPKAPK5 inhibitors, Matrix me tallopro tease inhibitors, MCL1 gene inhibitors, MEK protein kinase inhibitors, MEK-1 protein kinase inhibitors, MEK-2 protein kinase inhibitors,
Membrane copper amine oxidase inhibitors, Metalloprotease-2 inhibitors,
Metalloprotease-9 inhibitors, Midkine ligand inhibitors, Mitochondrial 10 kDa heat shock protein stimulators, mTOR complex 1 inhibitors, mTOR inhibitors, NAD ADP ribosyltransferase stimulators, NAMPT gene inhibitors, NF kappa B inhibitor stimulators, NFAT gene inhibitors, NFE2L2 gene stimulators, Nicotinic acetylcholine receptor antagonists, NK cell receptor modulators, NKG2 A B activating NK receptor antagonists, NKG2 D activating NK receptor antagonists, Nuclear erythroid 2-related factor 2 stimulators, Nuclear factor kappa B inhibitors, Nuclear factor kappa B modulators, Nuclear factor kappa B pl05 inhibitors, Opioid growth factor receptor agonists, Opioid receptor delta antagonists, Osteoclast differentiation factor antagonists, Osteoclast differentiation factor ligand inhibitors, Oxidoreductase inhibitors, P2X7 purinoceptor agonists, p38 MAP kinase alpha inhibitors, p38 MAP kinase inhibitors, PDE 4 inhibitors, PDE 5 inhibitors, PDGF receptor agonists, PDGF receptor antagonists, PDGF-B ligand inhibitors, PERK gene inhibitors, Phosphoinositide-3 kinase delta inhibitors, Phosphoinositide-3 kinase gamma inhibitors, Phospholipase A2 inhibitors, Platelet activating factor receptor antagonists, PPAR gamma agonists, Programmed cell death protein 1 modulators, Prostaglandin D synthase stimulators, Protein arginine deiminase inhibitors, Protein tyrosine kinase inhibitors, PurH purine biosynthesis protein inhibitors, Rho associated protein kinase 2 inhibitors, Seprase inhibitors, Signal transducer CD24 modulators, Signal transduction inhibitors, Sodium glucose transporter-2 inhibitors, Sphingosine 1 phosphate phosphatase modulators, STAT3 gene inhibitors, Superoxide dismutase stimulators, SYK family tyrosine kinase inhibitors, Syk tyrosine kinase inhibitors, Syndecan-1 inhibitors, T cell receptor antagonists, T cell receptor modulators, T cell surface glycoprotein CD28 inhibitors, T cell surface glycoprotein CD28 stimulators, TAK1 binding protein modulators, Talin modulators, T-cell differentiation antigen CD6 inhibitors, T-cell surface glycoprotein CD8 inhibitors, Tenascin modulators, TGF beta agonists, Thymulin agonists, TLR-2 antagonists, TLR-4 antagonists, TLR-9 antagonists, TNF alpha ligand inhibitors, TNF alpha ligand modulators, TNF antagonists, TNF gene inhibitors, TNF receptor modulators, TNFSF11 gene inhibitors, Transcription factor p65 inhibitors,
Transcription factor RelB inhibitors, Transferrin modulators, Tumor necrosis factor 13C receptor antagonists, Tumor necrosis factor 15 ligand inhibitors, Tumor necrosis factor ligand 13 inhibitors, Tumor necrosis factor ligand inhibitors, Type I IL- 1 receptor antagonists, Type I TNF receptor antagonists, Type II TNF receptor modulators, Unspecified GPCR agonists, VEGF receptor antagonists, VEGF-2 receptor antagonists, VEGF-2 receptor modulators, VEGF-B ligand inhibitors, X-linked inhibitor of apoptosis protein inhibitors, Zap70 tyrosine kinase inhibitors, 99mTc labelled annexin V-128, abatacept, abatacept biosimilar, ABBV-257, ABT-122, ABT-494, acalabrutinib, aceclofenac, actarit, MS-392, adalimumab, adalimumab biosimilar, adalimumab follow-on biologic, AK-106, ALX-0061, aminopterin, anakinra, anakinra biosimilar, anakinra follow-on biologic, ARG-301, ASLAN-003, ASP-5094, AT-132, AZD-9567, baricitinib, BI-655064, bimekizumab, BiP (rheumatoid arthritis), Kings College London, BLHP-006, blisibimod, BMS-986104, BMS-986142, ABBV-
105, BTT-1023, canakinumab, Cartistem, CCX-354, CD24-IgFc, celecoxib, cerdulatinib, certolizumab pegol, CF-101, CFZ-533, CHR-5154, cibinetide, ciclosporin,
clazakizumab, CNTO-6785, corticotropin, Mallinckrodt, CR-6086, CreaVax-RA, CWG- 92, CWG-940, Cx-611, DE-098, deflazacort, Rheumavax, denosumab, diacerein, diclofenac, E-6011, eicosapentaenoic acid monoglycerides, etanercept, etanercept biosimilar, etanercept follow-on biologic, etodolac, etoricoxib, filgotinib, fosdagrocorat, gerilimzumab, ginsenoside C-K, givinostat, goat polyclonal antibodies, golimumab, GS- 5745, GS-9876, GSK-3196165, HM-71224, HMPL-523, hyaluronate sodium, IB-RA (injectable, rheumatoid arthritis), Innobioscience, IB-RA (oral, rheumatoid arthritis), Innobioscience, iguratimod, IMD-2560, imidazole salicylate, infliximab, infliximab biobetter, infliximab biosimilar, INS IX RA, interferon gamma follow-on biologic, interleukin-2 (injectable), interleukin-2 follow-on biologic, INV-103, IR-501, itolizumab, JNJ-40346527, Ka Shu Ning, KD-025, ketoprofen with omeprazole, leflunomide, lenzilumab, LLDT-8, lumiracoxib, LY-3090106, masitinib, mavrilimumab, MBS-2320, MEDI-5117, meloxicam, methotrexate, MGD-010, misoprostol with diclofenac, MM-AOl-01, monalizumab, MORAb-022, MPC-300-IV, MRC-375, nabumetone, namilumab, naproxen with esomeprazole, naproxen with esomeprazole strontium, ocaratuzumab, ofatumumab, OHR-118 , olokizumab, OM-89, once-daily naproxen (oral controlled release, pain), Alvogen, ONO-4059, Oralgam, ozoralizumab, peficitinib, pelubiprofen, PF-06687234, piperidone hydrochloridum, piroxicam, prednisolone, prednisone, Prosorba, PRT-2607, PRTX-100, PRX- 167700, QBSAU, rabeximod, RCT-18, recombinant human CD22 monoclonal antibody (iv infusion), Lonn Ryonn Pharma/SinoMab Bioscience (Shenzhen), recombinant human interleukin-1 receptor antagonist (rheumatoid arthritis), Shanghai Fudan-Zhangjiang Bio- Pharmaceutical, recombinant human interleukin-2 recombinant TNF receptor 2-Fc fusion protein mutant , RG-6125, RhuDex, rifabutin with clarithromycin with clofazimine, rituximab, rituximab biosimilar, rituximab follow-on biologic, RPI-78, SAN-300, sarilumab, SBI-087, seliciclib, SHR-0302, sirukumab, spebrutinib, SSS-07, KDDF- 201110-06, Syn-1002, T-5224, TAB-08, tacrolimus, TAK-020, TAK-079, tarenflurbil (transdermal spray gel, skin disease/rheumatoid arthritis), MIKA
Pharma/GALENpharma, technetium Tc 99m tilmanocept, technetium[99Tc] methylenediphosphonate, tenoxicam, Debio-0512, tocilizumab, tofacitinib, Trichuris suis ova, umbilical cord-derived mesenchymal stem cells (iv, RA/liver disease),
Alliancells/Zhongyuan Union, ustekinumab, VAY-736, VB-201, WF-10, XmAb-5871, YHB-1411-2; 14-3-3 protein eta inhibitors, such as anti-AGX-020 mAbs (rheumatoid arthritis), Augurex; 5 -Lipoxygenase inhibitors, such as tenoxicam, darbufelone, tebufelone, licofelone, ZD-2138, etalocib, tenidap, tepoxalin, flobufen, SKF-86002, PGV-20229, L-708780, WY-28342, T-0757, T-0799, ZM-216800, L-699333, BU- 4601A, SKF-104351, CI-986; Abl tyrosine kinase inhibitors, such as imatinib; ACTH receptor agonists, such as FAR-404, metenkefalin acetate with tridecactide acetate; Adenosine A3 receptor agonists, such as CF-101; Adenosine deaminase inhibitors, such as cladribine, pentostatin, FR- 221647; ADP ribosyl cyclase-1 modulators, such as indatuximab ravtansine; ADP ribosylation factor 6 inhibitors, such as NAV-2729;
Adrenocorticotrophic hormone ligands, such as corticotropin, Mallinckrodt, FAR-404, metenkefalin acetate with tridecactide acetate; Aggrecanase-2 inhibitors, such as GIBH- R-001-2; Albumin modulators, such as ALX-0061, ONS-1210; API transcription factor inhibitors, such as T-5224, tarenflurbil, SP-10030; Basigin inhibitors, such as ERG-240; Bcr protein inhibitors, such as imatinib; B-lymphocyte antigen CD19 inhibitors, such as XmAb-5871, MDX-1342; B-lymphocyte antigen CD20 inhibitors, such as ocrelizumab, ofatumumab, rituximab, rituximab biosimilar, veltuzumab, rituximab follow-on biologic, ocaratuzumab, BLX-301, IDEC-102, ABP-798, GP-2013, MK-8808, HLX-01, CT-P10, TL-011, PF-05280586, IBPM-001RX, IBI-301, AME-133v, BCD-020, BT-D004, SAIT- 101; B-lymphocyte antigen CD20 modulators, such as rituximab biosimilar, SBI-087, TRU-015, DXL-625; B-lymphocyte stimulator ligand inhibitors, such as belimumab, RCT-18, blisibimod, tabalumab, atacicept, briobacept; Bradykinin receptor modulators, such as givinostat; BRAF gene inhibitors, such as binimetinib; Branched amino acid aminotransferase 1 inhibitors, such as ERG-240; Bromodomain containing protein inhibitors, such as RVX-297, ZEN-003694; Btk tyrosine kinase inhibitors, such as acalabrutinib, HM-71224, spebrutinib, BTK inhibitor (rheumatoid arthritis), Humanwell Healthcare/Wuxi AppTech, BMS-986142, TAK-020, ONO-4059, TAS-5315, ABBV- 105, AC-0025, RN-486, CG-026806, GDC-0834; Cadherin-11 antagonists, such as RG- 6125; Calcineurin inhibitors, such as HS-378, ciclosporin; Calcium channel inhibitors, such as RP-3128; Carbonic anhydrase inhibitors, such as polmacoxib; Cathepsin K inhibitors, such as CRA-013783, T-5224, AM-3876, VEL-0230, NPI-2019; Cathepsin S inhibitors, such as MIV-247, AM-3876, RWJ-445380, NPI-2019; CCR1 chemokine antagonists, such as BX-471, BMS-817399, BI-638683, CCX-354, MLN-3701, MLN- 3897, CP-481715, PS-375179; CCR2 chemokine antagonists, such as MK-0812, AZD- 6942; CCR3 gene modulators, such as CM- 102; CCR5 chemokine antagonists, such as maraviroc, OHR-118, NIBR-6465, AZD-5672, AZD-8566; CD126 antagonists, such as sarilumab; CD29 modulators, such as PF-06687234; CD3 modulators, such as otelixizumab; CD39 agonists, such as AAV5-CD39/CD73 (rheumatoid arthritis), Arthrogen; CD4 agonists, such as maraviroc; CD4 antagonists, such as tregalizumab, zanolimumab, MTRX-1011A, BW-4162W94, EP-1645, clenoliximab; CD40 ligand inhibitors, such as dapirolizumab pegol; CD40 ligand receptor antagonists, such as BI- 655064, anti-CD40-XTEN, teneliximab; CD40 ligand receptor modulators, such as CFZ- 533; CD52 antagonists, such as alemtuzumab; CD73 agonists, such as AAV5-
CD39/CD73 (rheumatoid arthritis), Arthrogen; CD79b modulators, such as MGD-010; CD80 antagonists, such as RhuDex, XENP-9523, ASP-2408, abatacept biobetter; CD86 antagonists, such as ES-210, abatacept biosuperior, ASP-2408, XENP-9523; CD95 antagonists, such as DE-098, CS-9507; Cell adhesion molecule inhibitors, such as natalizumab, alicaforsen, NPC-17923, TK-280, PD-144795; Choline kinase inhibitors, such as choline kinase inhibitors (rheumatoid arthritis), UC San Diego; Clusterin stimulators, such as alemtuzumab; Complement C5 factor inhibitors, such as eculizumab, antisense oligonucleotides (rheumatoid arthritis), Leiden University Medical Center; Complement Factor stimulators, such as CM- 101; C-reactive protein inhibitors, such as IB-RA (oral, rheumatoid arthritis), Innobioscience, ISIS-353512; CSF-1 antagonists, such as masitinib, FPA-008, JNJ-27301937, JNJ-40346527, PLX-5622, CT-1578, PD- 360324, JNJ-28312141; CXC10 chemokine ligand inhibitors, such as 946414-98-8, BMS-936557; CXCR4 chemokine antagonists, such as plerixafor; Cyclin-dependent kinase inhibitor 1 inhibitors, such as CD K- 1/2/5/7/9 inhibitors
(cancer/tumorogenesis/rheumatoid arthritis), BioPatterns; Cyclin-dependent kinase-2 inhibitors, such as seliciclib, BP- 14; Cyclin-dependent kinase-4 inhibitors, such as CDK- 4/6 inhibitor (rheumatoid arthritis), Teijin; Cyclin-dependent kinase-5 inhibitors, such as BP-14; Cyclin-dependent kinase-6 inhibitors, such as CDK-4/6 inhibitor (rheumatoid arthritis), Teijin; Cyclin-dependent kinase-7 inhibitors, such as BP-14, seliciclib; Cyclin- dependent kinase-9 inhibitors, such as BP-14, seliciclib; Cyclooxygenase 2 inhibitors, such as celecoxib, etoricoxib, polmacoxib, laflunimus, etodolac, meloxicam, IB-RA (injectable, rheumatoid arthritis), Innobioscience, IB-RA (oral, rheumatoid arthritis), Innobioscience, SKLB-023, meloxicam, lumiracoxib; Cyclooxygenase 2 modulators, such as DRGT-46; Cyclooxygenase inhibitors, such as aceclofenac, diclofenac, imidazole salicylate, naproxcinod, naproxen etemesil, misoprostol with diclofenac, nabumetone, naproxen with esomeprazole, naproxen with esomeprazole strontium , once-daily naproxen (oral controlled release, pain), Alvogen, pelubiprofen, LY-210073, tenoxicam, licofelone, NS-398, bromfenac, L-746483, LY-255283, tenidap, tepoxalin, flobufen, ibuprofen , flurbiprofen , SKF-86002, SC-57666, WY-28342, CI-986, bermoprofen; Cytosolic phospholipase A2 inhibitors, such as AVX-002; Cytotoxic T- lymphocyte protein-4 modulators, such as belatacept, ES-210; Cytotoxic T-lymphocyte protein-4 stimulators, such as abatacept, abatacept biosimilar, BMS-188667; DHFR inhibitors, such as methotrexate, MPI-2505, MBP-Y003; Diamine acetyltransferase inhibitors, such as diminazene aceturate; Dihydroorotate dehydrogenase inhibitors, such as DHODH inhibitors (rheumatoid arthritis/autoimmune diseases), East China University of Science and Technology, ASLAN-003, laflunimus, leflunomide, HWA-486, ABR- 224050; Elongation factor 2 inhibitors, such as denileukin diftitox; Eotaxin 2 ligand inhibitors, such as CM- 102; EP4 prostanoid receptor antagonists, such as CR-6086; Erythropoietin receptor agonists, such as cibinetide; Fas ligands, such as AP-300; FGF-2 ligand inhibitors, such as RBM-007; FK506 binding protein-12 modulators, such as temsirolimus; Folate antagonists, such as methotrexate, MBP-Y003; Folate receptor agonists, such as folate receptor modulators (chimeric protein, cancer/rheumatoid arthritis), Proda Biotech; Folate receptor modulators, such as technetium (99mTc) etarfolatide; Fractalkine ligand inhibitors, such as E-6011; Fyn tyrosine kinase inhibitors, such as masitinib, laflunimus; G protein coupled receptor 15 antagonists, such as GPR15 antagonists (rheumatoid arthritis/HIV-mediated enteropathy), Omeros; GAB A A receptor modulators, such as laflunimus; Glucocorticoid agonists, such as prednisolone, fosdagrocorat; Glucocorticoid antagonists, such as REC-200; Glucocorticoid induced leucine zipper stimulators, such as ART-G01; GM-CSF ligand inhibitors, such as namilumab, MORAb-022, lenzilumab; GM-CSF receptor antagonists, such as mavrilimumab; GM-CSF receptor modulators, such as GSK-3196165; Growth regulated protein alpha ligand inhibitors, such as T-5224; Hwith Kwith ATPase inhibitors, such as naproxen with esomeprazole, naproxen with esomeprazole strontium, ketoprofen with omeprazole, KEO-25001, HC-1004, PN-40020; Histamine H4 receptor antagonists, such as toreforant, GD-48; Histone deacetylase inhibitors, such as givinostat, CHR-5154; Histone deacetylase-6 inhibitors, such as CKD-506; HIV-1 gpl20 protein inhibitors, such as maraviroc; HLA class II antigen DQ-2 alpha modulators, such as NexVax2; HLA class II antigen inhibitors, such as HLA-DR1/DR4 inhibitors (rheumatoid arthritis), Provid; HLA class II antigen modulators, such as ARG-301, recombinant T-cell receptor ligand (rheumatoid arthritis), Artielle; Hsp 70 family inhibitors, such as gusperimus trihydrochloride; Hypoxia inducible factor-1 inhibitors, such as 2-methoxyestradiol; IFNB gene stimulators, such as ART- 102; I-kappa B kinase beta inhibitors, such as IMD-2560, IMD-0560; I-kappa B kinase inhibitors, such as bardoxolone methyl; IL-1 antagonists, such as rilonacept, IBPB-007-IL, antisense oligonucleotides (rheumatoid arthritis), Leiden University Medical Center, recombinant human interleukin-1 receptor antagonist (rheumatoid arthritis), Shanghai Fudan-Zhangjiang Bio-Pharmaceutical; IL-10 agonists, such as peg-ilodecakin; IL-11 agonists, such as oprelvekin; IL-12 antagonists, such as ustekinumab, briakinumab, ddRNAi therapy (rheumatoid arthritis),
Medistem/Benitec; IL-15 antagonists, such as AMG-714, BNZ-132-2; IL-17 antagonists, such as ixekizumab, secukinumab, KD-025; IL-17 receptor modulators, such as CNTO- 6785; IL-2 agonists, such as interleukin-2 follow-on biologic; IL-2 antagonists, such as IB-RA (injectable, rheumatoid arthritis), Innobioscience, IB-RA (oral, rheumatoid arthritis), Innobioscience, BNZ-132-2; IL-21 antagonists, such as NN-8828, BNZ-132-2; IL-23 antagonists, such as ustekinumab, briakinumab; IL-3 antagonists, such as anti-IL-3 mAbs (rheumatoid arthritis), University of Regensburg; IL-4 agonists, such as SER-130- AMI; IL-6 antagonists, such as olokizumab, clazakizumab, sirukumab, SA-237, tocilizumab, ALX-0061, FB-704A, OP-R003, peptide IL-6 antagonist, MEDI-5117, T- 5224, humanized anti-IL-6 mAb, tocilizumab biosimilar, IL-6 neutralizing human antibodies, anti-IL6 antibody, RN-486, BLX-1002, AMG-220, FM-101, K-832, BLX- 1025, esonarimod, TA-383; IL-6 receptor modulators, such as tocilizumab, tocilizumab biosimilar, RO-4877533; Immunoglobulin antagonists, such as iguratimod;
Immunoglobulin Gl agonists, such as canakinumab, infliximab biobetter, infliximab biosimilar, BX-2922, STI-002, HF-1020; Immunoglobulin Gl antagonists, such as YHB- 1411-2; Immunoglobulin Gl modulators, such as CFZ-533, lenzilumab;
Immunoglobulin G2 antagonists, such as denosumab; Immunoglobulin G2 modulators, such as PF-547659; Immunoglobulin gamma Fc receptor II modulators, such as MGD- 010; Immunoglobulin gamma Fc receptor IIB antagonists, such as XmAb-5871;
Immunoglobulin kappa modulators, such as lenzilumab; Immunoglobulin M antagonists, such as IB-RA (injectable, rheumatoid arthritis), Innobioscience, IB-RA (oral, rheumatoid arthritis), Innobioscience; Inducible nitric oxide synthase inhibitors, such as SKLB-023; Inosine monophosphate dehydrogenase inhibitors, such as mycophenolate mofetil; Insulin sensitizers, such as rosiglitazone, THR-0921, HE-3286, BLX-1002; Integrin alpha- 1 /beta- 1 antagonists, such as SAN-300; Integrin alpha-4/beta- 1 antagonists, such as natalizumab; Integrin antagonists, such as PEG-HM-3, CY-9652; Interferon beta ligands, such as recombinant interferon beta-la, TA-383; Interferon gamma ligands, such as interferon gamma follow-on biologic; Interleukin 17 A ligand inhibitors, such as ABT-122, bimekizumab, ABBV-257; Interleukin 17F ligand inhibitors, such as bimekizumab; Interleukin 23A inhibitors, such as guselkumab;
Interleukin ligands, such as IBPB-007-IL; Interleukin receptor 17A antagonists, such as brodalumab; Interleukin- 1 beta ligand inhibitors, such as canakinumab, rilonacept, T- 5224, gevokizumab, BLX-1002, LY-2189102, PMI-001, K-832, CDP-484; Interleukin- 10 ligands, such as PF-06687234; Interleukin-2 ligands, such as denileukin diftitox, recombinant interleukin-2, interleukin-2 follow-on biologic, recombinant human interleukin-2, interleukin-2 (injectable); Interleukin-4 ligands, such as Tetravil;
Interleukin-6 ligand inhibitors, such as gerilimzumab, PF-4236921; Itk tyrosine kinase inhibitors, such as ARN-4079; JAK tyrosine kinase inhibitors, such as tofacitinib, SHR- 0302, cerdulatinib, peficitinib, deuterated tofacitinib analog, SD-900, CVXL-0074; Jakl tyrosine kinase inhibitors, such as ABT-494, baricitinib, ruxolitinib, filgotinib, tofacitinib, itacitinib, peficitinib, NIP-585, CS-944X, YJC-50018, GLPG-0555, MRK- 12; Jak2 tyrosine kinase inhibitors, such as baricitinib, ruxolitinib, CT-1578; JAK3 gene inhibitors, such as GBL-5b; Jak3 tyrosine kinase inhibitors, such as decernotinib, tofacitinib, peficitinib, AC-0025, CS-944X, DNX-04042, MTF-003, ARN-4079, PS- 020613; Jun N terminal kinase inhibitors, such as IQ-1S; KCNA voltage-gated potassium channel-3 modulators, such as MRAD-P1; Kelch like ECH associated protein 1 modulators, such as dimethyl fumarate; Kit tyrosine kinase inhibitors, such as imatinib, masitinib; LanC like protein 2 modulators, such as BT-11; LITAF gene inhibitors, such as GBL-5b; Lymphocyte function antigen-3 receptor antagonists, such as alefacept; Lyn tyrosine kinase inhibitors, such as masitinib; Macrophage mannose receptor 1 modulators, such as technetium Tc 99m tilmanocept; MAdCAM inhibitors, such as PF- 547659; MAP kinase modulators, such as SKLB-023; MAP3K2 gene inhibitors, such as GBL-5b; MAPKAPK5 inhibitors, such as GLPG-0259; Matrix metalloprotease inhibitors, such as GLPG-0259; MCL1 gene inhibitors, such as seliciclib; MEK protein kinase inhibitors, such as binimetinib, AD-GL0001; MEK-1 protein kinase inhibitors, such as binimetinib; MEK-2 protein kinase inhibitors, such as binimetinib; Membrane copper amine oxidase inhibitors, such as BTT-1023, PRX- 167700, vepalimomab;
Metalloprotease-2 inhibitors, such as ERG-240; Metalloprotease-9 inhibitors, such as GS-5745, ERG-240; Midkine ligand inhibitors, such as CAB-102; Mitochondrial 10 kDa heat shock protein stimulators, such as INV-103; mTOR complex 1 inhibitors, such as everolimus; mTOR inhibitors, such as everolimus, temsirolimus; NAD ADP
ribosyltransferase stimulators, such as denileukin diftitox; NAMPT gene inhibitors, such as ART-D01; NF kappa B inhibitor stimulators, such as denosumab; NFAT gene inhibitors, such as T-5224; NFE2L2 gene stimulators, such as bardoxolone methyl; Nicotinic acetylcholine receptor antagonists, such as RPI-78, RPI-MN; NK cell receptor modulators, such as masitinib; NKG2 A B activating NK receptor antagonists, such as monalizumab; NKG2 D activating NK receptor antagonists, such as NNC-0142-002; Nuclear erythroid 2-related factor 2 stimulators, such as dimethyl fumarate; Nuclear factor kappa B inhibitors, such as bardoxolone methyl, IB-RA (injectable, rheumatoid arthritis), Innobioscience, dehydroxymethylepoxyquinomicin, HE-3286, IMD-0560, MP- 42, tarenflurbil, VGX-1027, SKLB-023, SP-650003, MG-132, SIM-916, VGX-350, VGX-300, GIT-027, SP-100030, MLN-1145, NVP-IKK-005; Nuclear factor kappa B modulators, such as REM-1086; Nuclear factor kappa B pl05 inhibitors, such as REM- 1086; Opioid growth factor receptor agonists, such as metenkefalin acetate with tridecactide acetate, FAR-404; Opioid receptor delta antagonists, such as HS-378;
Osteoclast differentiation factor antagonists, such as denosumab, cyclic peptidomimetics (rheumatoid arthritis/osteoporosis), University of Michigan; Osteoclast differentiation factor ligand inhibitors, such as denosumab; Oxidoreductase inhibitors, such as etodolac, imidazole salicylate; P2X7 purinoceptor agonists, such as givinostat; p38 MAP kinase alpha inhibitors, such as VX-745, BMS-582949 prodrugs, BMS-751324; p38 MAP kinase inhibitors, such as BCT-197, losmapimod, ARRY-797; PDE 4 inhibitors, such as apremilast; PDE 5 inhibitors, such as PDE5 inhibitors (rheumatoid arthritis), University of Rochester; PDGF receptor agonists, such as oprelvekin; PDGF receptor antagonists, such as imatinib, masitinib; PDGF-B ligand inhibitors, such as SL-1026; PERK gene inhibitors, such as binimetinib; Phosphoinositide-3 kinase delta inhibitors, such as duvelisib, RP-6503, CT-732, INK-007, GNE-293; Phosphoinositide-3 kinase gamma inhibitors, such as duvelisib, RP-6503; Phospholipase A2 inhibitors, such as AVX-002, human secreted phospholipase A2 type IIA-integrin binding inhibiting peptides
(rheumatoid arthritis/asthma/ Alzheimer' s disease/cancer), University of California, Davis, AK-106, varespladib methyl, Ro-31-4493, BM-162353, Ro-23-9358, YM-26734; Platelet activating factor receptor antagonists, such as piperidone hydrochloridum; PPAR gamma agonists, such as rosiglitazone, THR-0921, rosiglitazone XR, etalocib;
Programmed cell death protein 1 modulators, such as INSIX RA; Prostaglandin D synthase stimulators, such as HF-0220; Protein arginine deiminase inhibitors, such as PAD inhibitors (rheumatoid arthritis), Leiden University Medical Center/LURIS; Protein tyrosine kinase inhibitors, such as leflunomide; PurH purine biosynthesis protein inhibitors, such as mycophenolate mofetil; Rho associated protein kinase 2 inhibitors, such as KD-025; Seprase inhibitors, such as anti-fibroblast-activation protein (FAP) antibody radiotracers (rheumatoid arthritis), Hoffmann-La Roche/ Radboud University; Signal transducer CD24 modulators, such as CD24-IgFc; Signal transduction inhibitors, such as imatinib; Sodium glucose transporter-2 inhibitors, such as THR-0921;
Sphingosine 1 phosphate phosphatase modulators, such as SIP modulators (oral, multiple sclerosis/ ulcerative colitis/rheumatoid arthritis), Akaal Pharma; STAT3 gene inhibitors, such as bardoxolone methyl, vidofludimus; Superoxide dismutase stimulators, such as imisopasem manganese; SYK family tyrosine kinase inhibitors, such as MK- 8457; Syk tyrosine kinase inhibitors, such as fostamatinib, entospletinib, KDDF-201110- 06, HMPL-523, cerdulatinib, AB-8779, GS-9876, PRT-2607, CVXL-0074, CG-
103065and CG-026806; Syndecan-1 inhibitors, such as indatuximab ravtansine; T cell receptor antagonists, such as TCR inhibiting SCHOOL peptides (systemic/topical, rheumatoid arthritis/dermatitis/scleroderma), SignaBlok, CII modified peptide
(rheumatoid arthritis), Peking University; T cell receptor modulators, such as ARG-301; T cell surface glycoprotein CD28 inhibitors, such as abatacept, belatacept, abatacept biosimilar, RhuDex, BMS-188667; T cell surface glycoprotein CD28 stimulators, such as TAB-08; TAK1 binding protein modulators, such as epigallocatechin 3-gallate; Talin modulators, such as short-form talin regulators (rheumatoid arthritis), KayteeBio; T-cell differentiation antigen CD6 inhibitors, such as itolizumab; T-cell surface glycoprotein CD8 inhibitors, such as tregalizumab; Tenascin modulators, such as Tetravil; TGF beta agonists, such as tregalizumab; Thymulin agonists, such as Syn-1002; TLR-2 antagonists, such as VB-201, P-13; TLR-4 antagonists, such as VB-201, P-13; TLR-9 antagonists, such as P-13; TNF alpha ligand inhibitors, such as adalimumab
biosimilarYHB-1411-2, adalimumab, infliximab, infliximab biosimilar, recombinant humanized anti-TNF-alpha monoclonal antibody, certolizumab pegol, golimumab, ozoralizumab, AT-132, etanercept biosimilar, ISIS-104838, ISU-202, CT-P17, MB-612, Debio-0512, anti-TNF alpha human monoclonal antibody, infliximab biobetter, UB-721, KN-002, DA-3113, BX-2922, R-TPR-015, BOW-050, PF-06410293, CKD-760, CHS- 1420, GS-071, ABP-710, STI-002, BOW-015, FKB-327, BAX-2200, HLX-03, BI- 695501, CNTO-148, MYL-1401AABP-501, HOT-3010, BAX-2923, SCH-215596,
ABT-D2E7, BAT-1406, XPro-1595, Atsttrin, SSS-07, golimumab biosimilar, TA-101, adalimumab follow-on biologic, BLX-1002, ABX-0401, TAQ-588, golimumab biosimilar, TeHL-1, placulumab, PMI-001, tgAAV-TNFR:Fc, K-832, CYT-007-TNFQb, SSR-150106, PassTNF, Verigen, DOM-0200, DOM-0215, AME-527, anti-TNF-alpha mAb, GENZ-38167, BLX-1028, CYT-020-TNFQb, CC-1080, CC-1069; TNF alpha ligand modulators, such as MM-AOl-01, CDP-571, camobucol; TNF antagonists, such as etanercept, certolizumab pegol, etanercept follow-on biologic, etanercept biosimilar, DNX-114, TNF antagonist with IL-12 antagonist (rheumatoid arthritis), University of Oxford, BN-006, SCB-131, pegsunercept, GBL-5b, ACE-772, onercept, DE-096, PN- 0615, lenercept, ITF-1779, MDL-201112, BAX-2200, SCB-808, DA-3853, HD-203; TNF gene inhibitors, such as GIBH-R-001-2; TNF receptor modulators, such as recombinant TNF receptor 2-Fc fusion protein mutant, T-0001, tgAAV-TNFR:Fc;
TNFSF11 gene inhibitors, such as denosumab; Transcription factor p65 inhibitors, such as REM-1086; Transcription factor RelB inhibitors, such as REM-1086; Transferrin modulators, such as methotrexate, MBP-Y003; Tumor necrosis factor 13C receptor antagonists, such as VAY-736; Tumor necrosis factor 15 ligand inhibitors, such as anti- TL1A antibodies (rheumatoid arthritis/inflammatory bowel disease), NIAMS; Tumor necrosis factor ligand 13 inhibitors, such as atacicept; Tumor necrosis factor ligand inhibitors, such as ABBV-257, etanercept biosimilar, ABT-122; Type I IL-1 receptor antagonists, such as anakinra, anakinra biosimilar, anakinra follow-on biologic, AXXO; Type I TNF receptor antagonists, such as NM-9405; Type II TNF receptor modulators, such as etanercept, SCB-131, etanercept biosimilar, etanercept follow-on biologic, BAX- 2200, SCB-808, LBEC-0101, DMB-3853, DWP-422, BT-D001, DA-3853; Unspecified GPCR agonists, such as NCP-70X; VEGF receptor antagonists, such as 2- methoxyestradiol and NSC-650853, SL-1026; VEGF-2 receptor antagonists, such as CG-026806; VEGF-2 receptor modulators, such as VEGFR2 neutralizing antibody (rheumatoid arthritis), University of Rochester; VEGF-B ligand inhibitors, such as CSL- 346; X-linked inhibitor of apoptosis protein inhibitors, such as IAP inhibitors (oral), Pharmascience; and Zap70 tyrosine kinase inhibitors, such as MK-8457, CT-5332.
Combinations for Metabolic Diseases or Conditions
Examples of metabolic disorders include, without limitation, diabetes, including type I and type II diabetes, metabolic syndrome, dyslipidemia, obesity, glucose intolerance, hypertension, elevated serum cholesterol, and elevated triglycerides.
Examples of therapeutic agents used to treat metabolic disorders include
antihypertensive agents and lipid lowering agents. Additional therapeutic agents used to treat metabolic disorders include insulin, sulfonylureas, biguanides, alpha-glucosidase inhibitors, and incretin mimetics. Thus, one aspect of the disclosure is a method of treating a metabolic disease comprising administering a compound of the disclosure in combination with one or more compounds useful for the treatment of metabolic diseases to a subject, particularly a human subject, in need thereof.
PHARMACEUTICAL COMPOSITIONS
While it is possible for the active ingredients to be administered alone it may be preferable to present them as pharmaceutical formulations (compositions). The formulations, both for veterinary and for human use, of the invention comprise at least one active ingredient, as above defined, together with one or more acceptable carriers therefor and optionally other therapeutic ingredients. The carrier(s) must be
"acceptable" in the sense of being compatible with the other ingredients of the formulation and physiologically innocuous to the recipient thereof.
The formulations include those suitable for the foregoing administration routes. The formulations may conveniently be presented in unit dosage form and may be prepared by any of the methods well known in the art of pharmacy. Techniques and formulations generally are found in Remington's Pharmaceutical Sciences (Mack Publishing Co., Easton, PA). Such methods include the step of bringing into association the active ingredient with inactive ingredients (e.g., a carrier, pharmaceutical excipient, etc.) which constitutes one or more accessory ingredients. In general the formulations are prepared by uniformly and intimately bringing into association the active ingredient with liquid carriers or finely divided solid carriers or both, and then, if necessary, shaping the product.
In certain embodiments, formulations suitable for oral administration are presented as discrete units such as capsules, cachets or tablets each containing a predetermined amount of the active ingredient.
In certain embodiments, the pharmaceutical formulations include one or more compounds of the invention together with one or more pharmaceutically acceptable carriers or excipients and optionally other therapeutic agents. Pharmaceutical formulations containing the active ingredient may be in any form suitable for the intended method of administration. When used for oral use for example, tablets, troches, lozenges, aqueous or oil suspensions, dispersible powders or granules, emulsions, hard or soft capsules, syrups or elixirs may be prepared. Compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents including sweetening agents, flavoring agents, coloring agents and preserving agents, in order to provide a palatable preparation. Tablets containing the active ingredient in admixture with non-toxic pharmaceutically acceptable excipient which are suitable for manufacture of tablets are acceptable. These excipients may be, for example, inert diluents, such as calcium or sodium carbonate, lactose, lactose monohydrate, croscarmellose sodium, povidone, calcium or sodium phosphate; granulating and disintegrating agents, such as maize starch, or alginic acid; binding agents, such as cellulose, microcrystalline cellulose, starch, gelatin or acacia; and lubricating agents, such as magnesium stearate, stearic acid or talc. Tablets may be uncoated or may be coated by known techniques including microencapsulation to delay disintegration and adsorption in the gastrointestinal tract and thereby provide a sustained action over a longer period. For example, a time delay material such as glyceryl monostearate or glyceryl distearate alone or with a wax may be employed.
The amount of active ingredient that is combined with the inactive ingredients to produce a dosage form will vary depending upon the host treated and the particular mode of administration. For example, in some embodiments, a dosage form for oral administration to humans contains approximately 1 to 1000 mg of active material formulated with an appropriate and convenient amount of carrier material (e.g., inactive ingredient or excipient material). In certain embodiments, the carrier material varies from about 5 to about 95% of the total compositions (weight: weight). In some embodiments, the pharmaceutical compositions described herein contain about 1 to 800 mg, 1 to 600 mg, 1 to 400 mg, 1 to 200 mg, 1 to 100 mg or 1 to 50 mg of the compound of Formula I, or a pharmaceutically acceptable salt thereof. In some embodiments, the pharmaceutical compositions described herein contain not more than about 400 mg of the compound of Formula I. In some embodiments, the pharmaceutical compositions described herein contain about 100 mg of the compound of Formula I, or a pharmaceutically acceptable salt thereof.
It should be understood that in addition to the ingredients particularly mentioned above the formulations disclosed herein may include other agents conventional in the art having regard to the type of formulation in question, for example those suitable for oral administration may include flavoring agents.
Veterinary compositions comprising at least one active ingredient as above defined together with a veterinary carrier are further provided.
Veterinary carriers are materials useful for the purpose of administering the composition and may be solid, liquid or gaseous materials which are otherwise inert or acceptable in the veterinary art and are compatible with the active ingredient. These veterinary compositions may be administered orally, parenterally or by any other desired route.
Effective dose of active ingredient depends at least on the nature of the condition being treated, toxicity, whether the compound is being used prophylactically (lower doses), the method of delivery, and the pharmaceutical formulation, and will be determined by the clinician using conventional dose escalation studies.
ROUTES OF ADMINISTRATION
One or more compounds of Formula I (herein referred to as the active ingredients), or a pharmaceutically acceptable salt thereof, are administered by any route appropriate to the condition to be treated. Suitable routes include oral, rectal, nasal, topical (including buccal and sublingual), vaginal and parenteral (including
subcutaneous, intramuscular, intravenous, intradermal, intrathecal and epidural), and the like. It will be appreciated that the preferred route may vary with for example the condition of the recipient. An advantage of the compounds of this invention is that they are orally bioavailable and can be dosed orally. Accordingly, in one embodiment, the pharmaceutical compositions described herein are oral dosage forms. In certain embodiments, the pharmaceutical compositions described herein are oral solid dosage forms.
Formulation Example 1
Hard gelatin capsules containing the following ingredients are prepared:
Quantity
Ingredient (mg/capsule)
Active Ingredient 30.0
Starch 305.0
Magnesium stearate 5.0
The above ingredients are mixed and filled into hard gelatin capsules. Formulation Example 2
Formula is prepared using the ingredients below:
Quantity
Ingredient (mg/tablet)
Active Ingredient 25.0
Cellulose, microcrystalline 200.0
Colloidal silicon dioxide 10.0
Stearic acid 5.0
The components are blended and compressed to form tablets.
Formulation Example 3
A dry powder inhaler formulation is prepared containing the following components:
Ingredient Weight %
Active Ingredient 5
Lactose 95
The active ingredient is mixed with the lactose and the mixture is added to a dry powder inhaling appliance.
Formulation Example 4
Tablets, each containing 30 mg of active ingredient, are prepared as follows:
Quantity
Ingredient (mg/tablet)
Active Ingredient 30.0 mg
Starch 45.0 mg
Microcrystalline cellulose 35.0 mg
Polyvinylpyrrolidone
(as 10% solution in sterile water) 4.0 mg
Sodium carboxymethyl starch 4.5 mg
Magnesium stearate 0.5 mg
Talc 1.0 mg
Total 120 mg
The active ingredient, starch and cellulose are passed through a No. 20 mesh U.S. sieve and mixed thoroughly. The solution of polyvinylpyrrolidone is mixed with the resultant powders, which are then passed through a 16 mesh U.S. sieve. The granules so produced are dried at 50 °C to 60 °C and passed through a 16 mesh U.S. sieve. The sodium carboxymethyl starch, magnesium stearate and talc, previously passed through a No. 30 mesh U.S. sieve, are then added to the granules which, after mixing, are compressed on a tablet machine to yield tablets each weighing 120 mg.
Formulation Example 5
Suppositories, each containing 25 mg of active ingredient are made as follows:
Ingredient Amount
Active Ingredient 25 mg
Saturated fatty acid glycerides to 2,000 mg
The active ingredient is passed through a No. 60 mesh U.S. sieve and suspended in the saturated fatty acid glycerides previously melted using the minimum heat necessary. The mixture is then poured into a suppository mold of nominal 2.0 g capacity and allowed to cool.
Formulation Example 6
Suspensions, each containing 50 mg of active ingredient per 5.0 mL dose are made as follows:
Ingredient Amount
Active Ingredient 50.0 mg
Xanthan gum 4.0 mg
Sodium carboxymethyl cellulose (11%)
Microcrystalline cellulose (89%) 50.0 mg
Sucrose 1.75 g
Sodium benzoate 10.0 mg
Flavor and Color q.v.
Purified water to 5.0 mL
The active ingredient, sucrose and xanthan gum are blended, passed through a No. 10 mesh U.S. sieve and then mixed with a previously made solution of the microcrystalline cellulose and sodium carboxymethyl cellulose in water. The sodium benzoate, flavor and color are diluted with some of the water and added with stirring. Sufficient water is then added to produce the required volume. Formulation Example 7
A subcutaneous formulation may be prepared as follows:
Ingredient Quantity
Active Ingredient 5.0 mg
Corn Oil 1.0 mL
Formulation Example 8
An injectable preparation is prepared having the following composition
Ingredients
Active ingredient
Mannitol, USP
Gluconic acid, USP
water (distilled, sterile)
Nitrogen Gas, NF
Formulation Example 9
A topical preparation is prepared having the following composition:
Ingredients grams
Active ingredient 0.2-10
Span 60 2.0
Tween 60 2.0
Mineral oil 5.0
Petrolatum 0.10
Methyl paraben 0.15
Propyl paraben 0.05
BHA (butylated hydroxy anisole) 0.01
Water q.s. tolOO
All of the above ingredients, except water, are combined and heated to 60°C with stirring. A sufficient quantity of water at 60°C is then added with vigorous stirring to emulsify the ingredients and water then added q.s. 100 g. Formulation Example 10
Sustained Release Composition
Ingredient Weight Range%
Active ingredient 50-95
Microcrystalline cellulose (filler) 1-35
Methacry lie acid copolymer 1-35
Sodium hydroxide 0.1-1.0
Hydroxypropyl methylcellulose 0.5-5.0
Magnesium stearate 0.5-5.0
Sustained release formulations of this disclosure may be prepared as follows:
compound and pH-dependent binder and any optional excipients are intimately mixed(dry-blended). The dry-blended mixture is then granulated in the presence of an aqueous solution of a strong base which is sprayed into the blended powder. The granulate is dried, screened, mixed with optional lubricants (such as talc or magnesium stearate) and compressed into tablets. Preferred aqueous solutions of strong bases are solutions of alkali metal hydroxides, such as sodium or potassium hydroxide, preferably sodium hydroxide, in water (optionally containing up to 25% of water-miscible solvents such as lower alcohols).
The resulting tablets may be coated with an optional film-forming agent, for
identification, taste-masking purposes and to improve ease of swallowing. The film forming agent will typically be present in an amount ranging from between 2% and 4% of the tablet weight. Suitable film- forming agents are well known to the art and include hydroxypropyl methylcellulose, cationic methacrylate copolymers (dimethylaminoethyl methacrylate/ methyl-butyl methacrylate copolymers - Eudragit® E - Rohm. Pharma) and the like. These film-forming agents may optionally contain colorants, plasticizers and other supplemental ingredients.
The compressed tablets preferably have a hardness sufficient to withstand 8 Kp compression. The tablet size will depend primarily upon the amount of compound in the tablet. The tablets will include from 300 to 1100 mg of compound free base. Preferably, the tablets will include amounts of compound free base ranging from 400-600 mg, 650-850 mg and 900-1100 mg.
In order to influence the dissolution rate, the time during which the compound containing powder is wet mixed is controlled. Preferably the total powder mix time, i.e. the time during which the powder is exposed to sodium hydroxide solution, will range from 1 to 10 minutes and preferably from 2 to 5 minutes. Following granulation, the particles are removed from the granulator and placed in a fluid bed dryer for drying at about 60°C.
Formulation Example 11
A tablet Formula Is prepared using the ingredients below:
Quantity
Ingredient (mg/tablet)
Active Ingredient 300.0
Cellulose, microcrystalline 100.0
Colloidal silicon dioxide 10.0
Stearic acid 5.0
The components are blended and compressed to form tablets.
EXAMPLES
The following examples are included to demonstrate specific embodiments of the disclosure. It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques to function well in the practice of the disclosure, and thus can be considered to constitute specific modes for its practice. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the spirit and scope of the disclosure.
List of Abbreviations and Acronyms
Abbreviation Meaning
°C Degree Celsius
Ac Acetyl
aq. Aqueous
ATP Adenosine triphosphate
B2Pin2 Bis(pinacolato)diboron BOC tert-Butoxycarbonyl
Br Broad
BSA Bovine serum albumin
D Doublet
DCM Dichloromethane
dd Doublet of doublets
ddd Doublet of doublet of doublets
DIPEA Ν,Ν-Diisopropylethylamine (Hiinig' s Base)
DMA Dimethylacetamide
DME 1,2-Dimethoxyethane
DMF Dimethylformamide
DMSO Dimethylsulfoxide
Dt Doublet-triplet
DTT Dithiothreitol (Cleland's reagent)
EC50 The half maximal effective concentration
EDC l-(3-dimethylaminopropyl)-3-ethylcarbodiimide
EDTA Ethylenediaminetetraacetic acid
EGFR Epidermal growth factor receptor
Eq Equivalents
ES/MS Electrospray mass spectrometry
Et Ethyl
EtOAc Ethyl acetate
EtOH Ethanol (Ethyl alcohol)
FBS Fetal bovine serum
G Grams
HATU l-[Bis(dimethylamino)methylene]-lH-l,2,3- triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate
HEPES 2- [4-(2-hydroxyethyl)piperazin- 1 - yljethanesulfonic acid
HC1 Hydrochloric acid
HPLC High pressure liquid chromatography
Hrs Hours
HTRF® Homogeneous time resolved fluorescence, a registered trademark of Cisbio Bioassays, pare marcel boiteux 30200 codolet, France
Hz Hertz
IBD Inflammatory bowel disease
IC50 Half-maximal inhibitory concentration i-pr Isopropyl
J Coupling constant (MHz)
K3PO4 Tripotasium phosphate
KOtBu Potassium tert-butoxide
KOAc Potassium Acetate
LCMS Liquid chromatography-mass spectrometry
Li HMDS Lithium bis(trimethylsilyl)amide
LiOH Lithium hydroxide
Lil Lithium iodide
LPS Lipopolysaccharide
M Molar
M multiplet
M+ Mass peak
M+H+ Mass peak plus hydrogen
Me Methyl
MeCN Acetonitrile MeOH Methanol (Methyl alcohol)
MeLi Methyllithium
MeMgX Methylmagnesium halide (Grignard reagent), where X is Fluoro, Chloro, Bromo or lodo
Me6Sn2 Hexamethyldistannane (hexamethylditin)
Mg Milligram
MgS04 Magnesium sulfate
MHz Megahertz
Min Minute
ml/mL Milliliter
mM Millimolar
Mmol Millimole
MS Mass spectroscopy
MsCl Mesyl chloride
NBS N-Bromosuccinimide
n- Normal
nBu/Bu n-Butyl (normal Butyl)
n-BuLi n-Butyl Lithium
NaH Sodium hydride
NaHCC>3 Sodium bicarbonate
NaN3 Sodium azide
Na3P04 Trisodium phosphate
Na2S04 Sodium sulfate
nL Nanoliter
Nm Nanometer
NMP l-methylpyrrolidin-2-one
NMR Nuclear magnetic resonance NP-40 Nonyl phenoxypolyethoxylethanol
Pd-PEPPSI™ -IPent [l,3-bis(2,6-di-3-pentylphenyl)imidazol-2- ylidene](3-chloropyridyl)palladium(II) dichloride
Pen-Strep Penicillin-Streptomycin (5,000 units of
penicillin G sodium salt, and 5,000 μg streptomycin sulfate in 0.85% saline)
Ph Phenyl
Q Quartet
q.s. Quantity sufficient to achieve a stated function
RP Reverse phase
RPMI Roswell Park Memorial Institute medium
Rt Room temperature
S Singlet
sat. Saturated
Selectfluor® l-Chloromethyl-4-fluoro-l,4- diazoniabicyclo[2.2.2]octane bis
(a trademark of Air Products and Chemicals) SFC Supercritical fluid chromatography
SiliaMetS® Thiol Silica-based Palladium scavenger, registered trademark of Silicycle
T Triplet
THF Tetrahydrofuran
TFA Trifluoroacetic acid
XPhos Pd G3 (2-Dicyclohexylphosphino-2',4',6'-triisopropyl- 1 , 1 '-biphenyl) [2-(2'-amino- 1,1'- biphenyl)]palladium(II) methanesulfonate 1. GENERAL SCHEMES Scheme 1:
Figure imgf000092_0001
The compounds of formula 1.5 may be accessed according to the method outlined in Scheme 1. 1-aminopyrrole 1.1 maybe be condensed with a suitable coupling partner to produce substituted pyrrolo[l,2-b]pyridazine 1.2 using a suitable catalyst (e.g, HC1, etc.) and suitable solvent (e.g., EtOH, etc.). Halogenation at the position shown using a known halogenating reagent (e.g., NBS, etc.) can form the intermediate 1.3, wherein X is chloro, bromo, or iodo and where intermediate 1.3 can be further substituted either via C-H activation or electrophilic aromatic substitution with a suitable reagent (e.g., selectfluor, etc.) to produce intermediate 1.4. Halogen metal exchange of -X to -M can then be achieved using a suitable reagent (e.g, n-BuLi, etc.) or transition metal coupling using a palladium catalyst and metal source (e.g., B2Pin2, Me6Sn2, etc.) to give intermediate 1.5, wherein M is a metal, such as tin or boron. Alternatively, a substituted 1-amino pyrrole 1.6 can be converted to the pyrrolo[l,2-b]pyridazine heterocycle 1.7 by the condensation described above. Heterocycle 1.7 can be converted via halogenation to an intermediate of the type 1.4. Scheme 2:
Figure imgf000093_0001
Compounds of Formula (I) may be assembled by first reacting an amine with intermediate 2.1 at C-4 to give intermediate 2.2. Following conversion to the acid 2.3 using a suitable reagent (e.g, LiOH, Lil and pyridine, etc.) a second amine can be introduced to give amide 2.4 using standard amide bond forming conditions (e.g., DIPEA with HATU, etc.). Coupling of the metal-containing species (1.5) with intermediate 2.4 using a suitable catalyst, such as a palladium catalyst, can afford a compound of Formula (I).
Scheme 3:
Figure imgf000093_0002
Alternatively, compounds of formula (I) may be assembled by first addition of amine to carboxylic acid 3.1 using standard amide bond formation (e.g., DIPEA with HATU, etc.) to give amide 3.2. Addition of an amine to the C-4 position of 3.2 may produce intermediate 2.4 which can in turn be coupled with intermediate 1.5 using a suitable catalyst, such as a palladium catalyst, to yield a compound of Formula (I). Scheme 4:
Figure imgf000094_0001
A compound of Formula (I) can also be prepared as shown in Scheme 4 beginning with the coupling of intermediate 2.2 and heterocycle 1.5 using a suitable catalyst, such as a palladium catalyst, to give compound 4.1. Conversion of the ester 4.1 to carboxylic acid 4.2 may be accomplished using known conditions (e.g. LiOH, Lil with pyridine, etc.). A compound of Formula (I) can be accessed by addition of an amine to intermediate 4.2 using standard amide bond forming conditions (e.g. HATU with DIPEA, etc.).
Scheme 5:
Figure imgf000094_0002
As shown in Scheme 5, an amine may be added to C-4 of compound 3.1 using base (e.g. NaH, LiHMDS, etc.) to directly yield intermediate 2.3. This can be converted to compound (I) in the same manner as illustrated in Scheme 2.
Scheme 6:
Figure imgf000094_0003
Beginning from intermediate 2.4, the compound may be reacted with an appropriate reagent (e.g. hexamethylditin, etc.) to afford compound 6.1. This can be coupled with halogenated heterocycle 1.4 using an appropriate catalyst (e.g. palladium catalyst, etc.) to yield compound (I).
Scheme 7:
Figure imgf000095_0001
In an alternate ordering of the synthesis, compound 2.1 may be initially coupled with intermediate 1.5 using a suitable catalyst, such as a palladium catalyst, to give monohalogenated product 7.1. Addition of an amine can produce intermediate ester 7.2 after which conversion to the carboxylic acid can yield intermediate 7.3. Addition of an amide using amide bond forming conditions (e.g., DIPEA with HATU, etc.) may produce compound (I).
Scheme 8:
Figure imgf000095_0002
Additionally, as shown in Scheme 8, ester 7.1 may be converted to the corresponding carboxylic acid 8.1 via known hydrolysis conditions (e.g. LiOH, Lil with pyridine, etc.). Amide bond formation using standard conditions (e.g., DIPEA with HATU, etc.) to produce intermediate 8.2 can then be followed by introduction of an amine into the C-4 position to give compound (I). Scheme 9:
Figure imgf000096_0001
Beginning with amide intermediate 3.2, coupling with heterocycle 1.5 using a suitable catalyst (e.g. palladium catalyst, etc.) may yield monohalogenated intermediate 9.2 which can be converted to compound (I) as described in Scheme 8.
Scheme 10:
Figure imgf000096_0002
It is also noted that synthetic manipulations of the incorporated R groups are possible following their incorporation. A specific illustrative example of an alteration to the R1 group is shown in Scheme 10 wherein the secondary amine 10.1 is reacted to form a methyl sulfonamide 10.2. Other functional groups may also be present in the R1 and can be manipulated. These groups and manipulations can include, but are not limited to, oxidation, elimination or displacement using suitable reagents known to those skilled in the art. The order of synthetic manipulations may be carried out in a fashion that is consistent with the methods outlined in Schemes 1-9 and should not be limited to the final step of compound preparation.
Scheme 11:
Figure imgf000096_0003
Variations of the R2 group may also be performed following formation of the amide. An illustrative example is shown in Scheme 11, though the groups present or synthetic manipulations performed are not limited to those shown in Scheme 11, wherein a methyl ester 11.1 is reacted with MeMgX or MeLi to yield the shown tertiary alcohol 11.2. The order of synthetic manipulations may be carried out in a fashion that is consistent with the methods outlined in Schemes 1-9 and should not be limited to the final step of compound preparation.
Scheme 12:
Figure imgf000097_0001
Manipulations of the R3, R4, R5, R6, and R7 groups present on the pyrrolo[l,2- bjpyridazine heterocycle may also be performed following its attachment to the pyridine core. An illustrative example is shown in Scheme 12 though the groups present and manipulations performed are not limited to those shown in the Scheme. A compound such as 12.1 with a cyano group may be converted to the corresponding carboxamide 12.2. The order of synthetic manipulations may be carried out in a fashion that is consistent with the methods outlined in Schemes 1-9 and should not be limited to the final step of compound preparation.
2. SYNTHESIS OF INTERMEDIATES Preparation of Intermediate 1-1:
Figure imgf000097_0002
1-1 F 1-1
3,3-Diethoxy-2-formylpropionitrile Potassium Salt (I-1C):
To a stirred solution of 3,3-diethoxypropane-nitrile (I-1A, 283.80 g, 1.98 moles) and methyl formate (I-1B, 148.80 g, 2.48 moles) in anhydrous THF (1.1 L) at 10 °C was added 1.0 M potassium tert-butoxide in THF (2.2 L, 2.2 moles). The temperature was maintained in the range of 10 °C to 15 °C throughout the 45 minute addition. Following the addition, the resulting slurry was stirred for 2 hours at ambient temperature. Hexane (400 mL) was then added and stirring was continued for another 20 min. The slurry was filtered and the cake washed with 1/1 hexanes/THF and dried overnight at 60 °C in a vacuum oven to provide I-IC. H-NMR (CD3OD) was consistent with the desired structure.
Pyrrolo[l,2-b]pyridazine-3-carbonitrile (I-1E):
A stirred suspension of 3,3-diethoxy-2-formylpropionitrile potassium salt (I-IC, 5.10 g, 24.36 mmol) was cooled to 0 °C, and concentrated HC1 (7.11 mL, 85.26 mmol) was added drop wise at such a rate that the internal temperature of the reaction did not go above 20 °C. After addition was complete, the reaction was stirred at room temperature for 20 minutes. To this reaction mixture was added a solution of 1-aminopyrrole (I-1D, 1.00 g, 12.18 mmol) in methanol (4.0 mL). After addition, the reaction mixture was refluxed at 90 °C for 2 hours. When heating was complete, the reaction was cooled to room temperature and concentrated to about half of the original volume. Saturated aqueous sodium bicarbonate was added carefully to the resulting residue until bubbling stopped. The solution was extracted with two portions of ethyl acetate. The combined organic layers were dried over sodium sulfate, filtered, concentrated in vacuo, and the resulting residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide I-1E.
1H NMR (400 MHz, Chloroform-d) δ 8.16 - 8.03 (m, 2H), 7.93 (ddd, J = 2.6, 1.4, 0.6 Hz, 1H), 7.04 (dd, J = 4.5, 2.7 Hz, 1H), 6.84 (dd, J = 4.6, 1.4 Hz, 1H).
7-bromopyrrolo[l,2-b]pyridazine-3-carbonitrile (I-1F):
To a solution of pyrrolo[l,2-b]pyridazine-3-carbonitrile (I-1E, 840.0 mg, 5.9 mmol) in MeCN (30 mL) at room temperature was added N-bromosuccinimide in one portion. The reaction was stirred at room temperature for 30 minutes then poured into saturated aqueous sodium bicarbonate. The solution was concentrated in vacuo to remove the acetonitrile. The resulting aqueous layer was extracted with three portions of EtOAc. The combined organic layers were dried over sodium sulfate, filtered, concentrated in vacuo, and purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide I- 1F.
1H NMR (400 MHz, Chloroform-d) δ 8.28 (d, J = 2.1 Hz, 1H), 8.10 (d, J = 2.1 Hz, 1H), 7.12 (d, J = 4.8 Hz, 1H), 6.93 (d, J = 4.8 Hz, 1H). 7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3- carbonitrile (1-1):
A microwave vial was charged with 7-bromopyrrolo[l,2-b]pyridazine-3-carbonitrile (I- 1F, 416.5 mg, 1.9 mmol), bis(pinacolato)diboron (762.1 mg, 3.0 mmol), potassium acetate (552.3 mg, 5.6 mmol), and bis(triphenylphosphine)palladium(II) dichloride (65.8 mg, 0.094 mmol). Dioxane (8.0 mL) and DMF (4.0 mL) were added, and the reaction mixture was degassed with bubbling argon for 2 minutes. The vial was sealed and the reaction was heated at 120 °C in a microwave reactor for 60 minutes. After cooling, the reaction mixture was filtered and concentrated in vacuo. The resulting residue was partitioned between EtOAc and water. The aqueous layer was extracted with a second portion of EtOAc, and the combined organic layers were dried over sodium sulfate, filtered through a plug of Celite, and concentrated in vacuo. The resulting residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide 1-1.
1H NMR (400 MHz, Chloroform-d) δ 8.31 (d, J = 2.3 Hz, 1H), 8.14 (d, J = 2.2 Hz, 1H), 7.52 (d, J = 4.6 Hz, 1H), 6.84 (d, J = 4.6 Hz, 1H), 1.41 (s, 12H).
Preparation of Intermediate 1-2:
Figure imgf000099_0001
3-chloropyrrolo[l,2-b]pyridazine (1-2): 1-aminopyrrole (0.50 g, 6.1 mmol) was dissolved in 3: 1 MeOH:AcOH (16mL) at room temperature after which 2- chloromalonaldehyde (0.78 g, 7.3 mmol) was added. The resulting mixture was stirred at room temperature for 30 min. then heated to 80 °C for 16 hrs. The solvents were removed by rotary evaporation and the crude residue partitioned between water and EtOAc. The layers were separated and the aqueous layer was extracted once with EtOAc. The organic layers were combined, dried with MgS04, filtered and
concentrated. The crude residue was then purified via silica gel chromatography (eluent: EtOAc/hexanes) to give the product 3-chloropyrrolo[l,2-b]pyridazine (1-2).
1H NMR (400 MHZ, CHLOROFORM-D) Δ 7.93 (D, / = 2.5 HZ, 1H), 7.75 - 7.70 (M,
1H), 7.69 (D, / = 2.5 HZ, 1H), 6.86 (DD, / = 4.3, 2.8 HZ, 1H), 6.45 (DD, / = 4.3, HZ, 1H). Preparation of Intermediate 1-3:
Figure imgf000100_0001
Methyl 4,6-dibromonicotinate (1-3): Methyl 4,6-dichloronicotinate (5.0 g, 24.3 mmol) was suspended in hydrogen bromide (33% in Acetic Acid, 24 mL). The reaction vessel was sealed and heated to 60 °C for 4 hours. The reaction was cooled to room temperature and diluted with ¾0. The resulting solids were filtered, washed with ¾0. The solids were then suspended in ¾0 and basified with aqueous sodium hydroxide. The resulting aqueous solution was extracted with EtOAc (3 times). The resulting organic layers were combined, dried over Na2S04, and concentrated to provide methyl 4,6-dibromonicotinate.
ES/MS: 296.182 (M+H+).
Preparation of Intermediate 1-4:
Figure imgf000100_0002
Methyl 6-bromo-4-(isopropylamino)nicotinate (1-4): To a solution of methyl 4,6- dibromonicotinate (7.16 g, 24.3 mmol) in acetonitrile (125 mL) and ¾0 (3 mL) was added isopropylamine (15.3 mL, 177 mmol). The reaction vessel was sealed and heated to 80 °C for 2 hours. The resulting solution was cooled to room temperature and concentrated to dryness. The resulting oil was purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide methyl 6-bromo-4-(isopropylamino)nicotinate. ES/MS: 273.569 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 8.60 (s, 1H), 8.08 (s, 1H), 6.72 (s, 1H), 3.87 (s, 3H), 3.68 (dq, J = 13.1, 6.5 Hz, 1H), 1.28 (d, J = 6.4 Hz, 6H).
Figure imgf000101_0001
6-bromo-4-chloronicotinic acid. To a solution of methyl 6-bromo-4-chloronicotinate (15 g, 59.89 mmol) in methanol (240 mL) was added lithium hydroxide (2.93 g, 119.77 mmol) in water (68mL). The solution was heated to 43 °C overnight and subsequently cooled to room temperature. Aqueous hydrochloric acid (1M, 120 mL) was added and volatiles were removed in vacuo. The resulting slurry was filtered and washed with ¾0 to provide 6-bromo-4-chloronicotinic acid.
ES/MS: 237.967 (M+H+).
1H NMR (400 MHz, DMSO-d6) δ 8.75 (s, 1H), 8.03 (s, 1H).
(R)-6-bromo-4-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide. To a solution of 6-bromo-4-chloronicotinic acid (3 g, 12.69 mmol) in DMF (42 mL) was added HATU (6.27 g, 16.49 mmol), (R)-4-amino-3-fluoro-2-methylbutan-2-ol hydrochloride (2.4 g, 15.23 mmol), and N,N-Diisopropylethylamine (5.62 ml, 32.26 mmol). The resulting solution was stirred at room temperature overnight and subsequently diluted with ethyl acetate. The organic solution was washed with saturated aqueous lithium chloride (3 times), then dried over Na2S04, and the concentrated. The residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide (R)-6-bromo-4-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide.
ES/MS: 341.089 (M+H+).
1H NMR (400 MHz, DMSO-d6) δ 8.88 (t, J = 5.5 Hz, 1H), 8.41 (s, 1H), 8.01 (s, 1H), 4.82 (s, 1H), 4.28 (ddd, / = 49.3, 9.4, 2.0 Hz, 1H), 3.84 - 3.63 (m, 1H), 3.40 - 3.22 (m, 1H), 1.13 (d, 7 = 7.0 Hz, 6H).
(R)-4-chloro-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide (1-5). To a solution of (R)-6-bromo-4-chloro-N-(2-fluoro-3- hydroxy-3-methylbutyl)nicotinamide (0.2 g, 0.59 mmol) in DME (3.9 mL) was added 7- (4,4,5, 5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (0.24 g, 0.9 mmol), XPhos Pd G3 (0.05 g, 0.06 mmol), and aqueous potassium phosphate tribasic (2M, 0.59 mL, 1.18 mmol). The resulting solution was degassed with argon and heated to 120 °C for 12 minutes in a microwave reactor. The crude reaction mixture was purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide (R)-4-chloro- 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide.
ES/MS: 402.220 (M+H+).
Preparation of Intermediate 1-6:
Figure imgf000102_0001
Ethyl 6-chloro-4-(N-(methylsulfonyl)methylsulfonamido)nicotinate: To a solution of ethyl 4-amino-6-chloronicotinate (334 mg, 1.67 mmol) and triethylamine (0.7 mL, 5 mmol) in dichloromethane (5 mL), was added methanesulfonyl chloride ( 0.39 mL, 5 mmol) slowly. The mixture was stirred overnight. Diluted with EtOAc (20 mL) and washed with aqueous NaHCC>3, and brine. The organic layer was dried and concentrated. The mixture was purified by silica gel chromatography (eluent: EtOAc/hexanes)to afford desired product.
ES/MS: 357 [M+H]+
6-chloro-4-(methylsulfonamido)nicotinic acid (1-6): To a solution of ethyl 6-chloro-4- (N-(methylsulfonyl)methylsulfonamido)nicotinate (60 mg, 0.17 mmol) in THF/ MeOH (1 mL/ 0.5 mL), Lithium hydroxide (20 mg, 0.8 mmol) was added. It was heated to 50 °C for 3 hours. Acidified by HC1 (IN) and extracted with EtOAc. The organic layer was dried and concentrated to give 1-6 which was used without further purification.
ES/MS: 251 [M+H]+
Preparation of Intermediate 1-7:
Figure imgf000102_0002
I-7A I-7B 1-7 Methyl (2-(4-nitrophenyl)propan-2-yl)carbamate (I-7B):
To a solution of 2-(4-nitrophenyl)propan-2-amine (I-7A, 250 mg, 1.15 mmol) and pyridine (0.25 ml, 3.15 mmol) in DCM (10 mL) at 0 deg, was added methyl
chloroformate (0.11 ml, 1.43 mmol).The reaction was gradually warmed to room temperature and stirred for 2 days. The reaction was concentrated, diluted with EtOAc and washed with IN HC1 three times. The organic extract was dried over sodium sulfate to give I-7B.
ES/MS: 239.0 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 8.18 (d, J = 8.9 Hz, 2H), 7.56 (d, J = 8.9 Hz, 2H), 5.20 (s, 1H), 3.58 (s, 3H), 1.66 (s, 6H).
Methyl (2-(4-aminophenyl)propan-2-yl)carbamate (1-7):
A solution of methyl (2-(4-nitrophenyl)propan-2-yl)carbamate (I-7B, 101 mg, 0.424 mmol) in EtOH (10 mL) was degassed with argon and vacuum. Pd/C (10%, 26m g, 0.0248 mmol) was added and the mixture was stirred with a balloon of ¾ overnight. The reaction was filtered over a Celite plug, rinsed with EtOAc and the filtrate was concentrated to give 1-7.
1H NMR (400 MHz, Chloroform-d) δ 7.21 - 7.16 (m, 2H), 6.70 - 6.57 (m, 2H), 5.03 (s, 1H), 3.58 (s, 3H), 3.46 (s, 2H), 1.63 (s, 6H).
Preparation of Intermediate 1-8:
Figure imgf000103_0001
I-8A I-8B 1-8
Methyl (l-(4-nitrophenyl)cyclopropyl)carbamate (I-8B):
To a solution of l-(4-nitrophenyl)cyclopropan-l -amine (I-8A, 250 mg, 1.16 mmol) and pyridine (0.3 ml, 3.72 mmol) in DCM (10 mL) at 0 deg, was added methyl chloroformate (0.1 ml, 1.30 mmol).The reaction was gradually warmed to room temperature and stirred for 2 days. The reaction was concentrated, diluted with EtOAc and washed with IN HC1 three times. The organic extract was dried over sodium sulfate to give I-8B.
1H NMR (400 MHz, Chloroform-d) δ 8.14 (d, J = 8.9 Hz, 2H), 7.33 (d, J = 8.9 Hz, 2H), 5.44 (s, 1H), 3.69 (s, 3H), 1.40 (m, 4H). Methyl (l-(4-aminophenyl)cyclopropyl)carbamate (1-8):
A solution of methyl (l-(4-nitrophenyl)cyclopropyl)carbamate (I-8B, 227 mg, 0.961 mmol) in EtOH (15 mL) was degassed with argon and vacuum. To this was added Pd/C (10%, 60 mg, 0.0564 mmol) and the mixture was stirred with a balloon of ¾ overnight. The reaction was filtered over a Celite plug, rinsed with EtOAc and the filtrate was concentrated to give 1-8.
1H NMR (400 MHz, Chloroform-d) δ 7.08 (dd, J = 33.4, 8.0 Hz, 2H), 6.72 - 6.56 (m, 2H), 5.44 (s, 1H), 3.62 (d, J = 4.8 Hz, 3H), 3.09 (d, J = 47.9 Hz, 2H), 1.22 (t, J = 7.0 Hz, 4H).
Preparation of Intermediate 1-9:
Figure imgf000104_0001
I-9A I-9B 1-9
Methyl (l-(4-nitrophenyl)cyclopropyl)acetamide (I-9B):
To a solution of l-(4-nitrophenyl)cyclopropan-l -amine (I-9A, 250 mg, 1.16 mmol) and pyridine (0.3 ml, 3.72 mmol) in DCM (10 mL) at 0 °C, was added acetic anhydride (0.12 ml, 1.27 mmol) The reaction was gradually warmed to room temperature and stirred for 2 days. The reaction was concentrated, diluted with EtOAc and washed with IN HC1 three times. The organic extract was dried over sodium sulfate, filtered and concentrated to give I-9B.
ES/MS: 221.0 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 8.13 (d, J = 8.9 Hz, 2H), 7.30 (d, J = 8.9 Hz, 2H), 6.15 (s, 1H), 2.04 (s, 3H), 1.40 (s, 4H). Methyl (l-(4-aminophenyl)cyclopropyl)acetamide (1-9):
A solution of methyl (l-(4-nitrophenyl)cyclopropyl)acetamide (I-9B, 217 mg, 0.985 mmol) in EtOH (15 mL) was degassed with argon and vacuum, then added Pd/C (10%, 60 mg, 0.0564 mmol) and stirred with a balloon of ¾ overnight. The reaction was filtered over a Celite plug, rinsed with EtOAc and the filtrate was concentrated to give I- 9. 1H NMR (400 MHz, Chloroform-d) δ 7.06 (d, J = 8.4 Hz, 2H), 6.64 (d, J = 8.4 Hz, 2H), 5.59 (d, J = 8.1 Hz, 1H), 3.72 - 3.38 (m, 2H), 1.95 (s, 3H), 0.85 (t, J = 7.4 Hz, 4H).
Preparation of Intermediate I- 10:
ne H
Figure imgf000105_0001
1-10 tert-butyl (S)-3-(4-nitro-lH-pyrazol-l-yl)pyrrolidine-l-carboxylate (I-10C):
To a solution of 4-nitro-lH-pyrazole (I-10A, 250 mg, 2.211 mmol) in DMF (5 mL) at 0 °C, was added sodium hydride , 60%disp. in oil (60%, 133 mg, 3.316 mmol). After stirring for 1.5 hr, a solution of tert-butyl (R)-3-((methylsulfonyl)oxy)pyrrolidine-l- carboxylate (I-10B, 704 mg, 2.653 mmol) in 5 mL DMF was added and the mixture was heated at 95 °C overnight. The reaction mixture was diluted with EtOAc and washed with brine twice. The organic extract was dried over sodium sulfate and purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide I-10C.
1H NMR (400 MHz, Chloroform-d) δ 8.16 (s, 1H), 8.13 - 8.01 (m, 1H), 4.89 (p, J = 5.7 Hz, 1H), 3.87 (dd, J = 12.0, 6.5 Hz, 1H), 3.77 (s, 1H), 3.57 (s, 2H), 2.60 - 2.34 (m, 2H), 1.48 (s, 9H).
(S)-4-nitro-l-(pyrrolidin-3-yl)-lH-pyrazole hydrochloride (I-10D):
To a solution of tert-butyl (S)-3-(4-nitro-lH-pyrazol-l-yl)pyrrolidine-l-carboxylate (I- 10C, 248.3 mg, 0.880 mmol) in DCM (3 mL) was added 750 uL HCl (4.0M in dioxane). After 4 hr, HCl (1 mL) and MeOH (1 mL) was added. The reaction was heated at 40 °C overnight. The reaction mixture was concentrated to dryness to give I-10D.
ES/MS: 183.2 (M+H+).
(S)-4-nitro-l-(l-(oxetan-3-yl)pyrrolidin-3-yl)-lH-pyrazole (I-10E): To a solution of (S)-4-nitro-l-(pyrrolidin-3-yl)-lH-pyrazole hydrochloride (I-10D, 186 mg, 0.851 mmol), triethylamine (0.12 mL, 0.861 mmol), and 3-oxetanone (0.250 mL, 4.267 mmol) in DCE (5 mL), was added AcOH (250 uL). The reaction was stirred at room temperature for 3 hr. Sodium cyanoborohydride (270 mg, 4.296 mmol) was added and the reaction was heated at 55 °C overnight. The reaction was partitioned with DCM and brine. The organic extract was dried over sodium sulfate and the resulting residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide I-10E. ES/MS: 239.2 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 8.39 (d, J = 0.6 Hz, 1H), 8.05 (d, J = 0.7 Hz, 1H), 5.01 - 4.86 (m, 1H), 4.72 (td, J = 6.6, 2.8 Hz, 2H), 4.67 (t, J = 6.1 Hz, 1H), 4.63 (t, J = 6.1 Hz, 1H), 3.77 (tt, J = 6.8, 5.8 Hz, 1H), 2.98 (ddd, J = 17.9, 9.1, 3.8 Hz, 2H), 2.86 (dd, J = 10.2, 6.7 Hz, 1H), 2.63 - 2.45 (m, 2H), 2.30 - 2.05 (m, 1H).
(S)-l-(l-(oxetan-3-yl)pyrrolidin-3-yl)-lH-pyrazol-4-amine (1-10):
A solution of (S)-4-nitro-l-(l-(oxetan-3-yl)pyrrolidin-3-yl)-lH-pyrazole (I-10E, 82.8 mg, 0.348 mmol) in EtOH (5 mL) was degassed with argon and vacuum, and then Pd/C (10%, 22 mg, 0.021 mmol) was added and the mixture was stirred with a balloon of ¾ overnight. The reaction was filtered over a Celite plug, rinsed with EtOAc and the filtrate was concentrated to give 1-10.
ES/MS: 209.1 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 7.21 (d, J = 0.9 Hz, 1H), 7.12 (d, J = 1.0 Hz, 1H), 4.77 (ddt, J = 9.4, 7.2, 4.7 Hz, 1H), 4.69 (td, J = 6.6, 2.7 Hz, 2H), 4.63 (dt, J = 10.4, 6.0 Hz, 2H), 3.82 - 3.62 (m, 1H), 2.82 (pd, J = 8.8, 7.9, 3.9 Hz, 3H), 2.53 (td, J = 8.5, 6.3 Hz, 1H), 2.41 (dtd, J = 13.8, 8.6, 5.4 Hz, 1H), 2.25 - 2.04 (m, 1H).
Preparation of Intermediate 1-11:
Figure imgf000106_0001
1-11
(R)-4-(dibenzylamino)-3-fluoro-2-methylbutan-2-yl acetate:
To a solution of (R)-4-(dibenzylamino)-3-fluoro-2-methylbutan-2-ol (800.0 mg, 2.6 mmol) and acetic anhydride (0.276 mL, 2.9 mmol) was added DMAP (16.2 mg, 0.13 mmol) and triethylamine (0.56 mL, 4.0 mmol). The reaction mixture was heated to 100 °C until complete consumption of starting material was observed by mass spectrometry. Upon completion, the reaction mixture was concentrated in vacuo and purified by silica gel column chromatography (eluent: EtOAc/hexanes) to provide the desired product. ES/MS: 344.2 (M+H+).
(R)-4-amino-3-fluoro-2-methylbutan-2-yl acetate (1-11):
To a solution of R)-4-(dibenzylamino)-3-fluoro-2-methylbutan-2-yl acetate (748.0 mg, 2.2 mmol) in EtOH (8.0 mL) and EtOAc (8.0 mL) was added Pd(OH)2 on carbon. The atmosphere was evacuated and back-flushed with hydrogen three times and then maintained under a hydrogen environment for the course of the reaction. After three hours, the reaction mixture was filtered and concentrated in vacuo to provide 1-11 which was used without additional purification.
ES/MS: 164.0 (M+H+).
Preparation of Intermediate 1-12:
Tert-butyl (3-acetamidobicyclo[ 1.1.1 ]pentan- 1 -yl)carbamate
Figure imgf000107_0001
Tert-butyl (3-acetamidobicyclo[l.l.l]pentan-l-yl)carbamate: To a solution of tert- butyl (3-aminobicyclo[l.l.l]pentan-l-yl)carbamate (303 mg, 1.5 mmol) in CH2CI2 (7.5 mL) at 0 °C was added saturated aqueous sodium bicarbonate (15 mL) and acetic anhydride (0.73 mL, 7.7 mmol). The biphasic solution was warmed to room temperature and stirred for 24 hours. The mixture was extracted with CH2CI2 (3 times). The combine organic layers were dried over MgS04 and concentrated to dryness. The resulting material was used without further purification.
1H NMR (400 MHz, Chloroform-d) δ 5.80 (s, 1H), 4.93 (s, 1H), 2.31 (s, 6H), 1.94 (s, 3H), 1.44 (s, 9H).
Preparation of Intermediate 1-13:
Figure imgf000108_0001
Ethyl 6-chloro-4-(((lS)-3-fluorocyclohexyl)amino)nicotinate: Ethyl 6-chloro-4- (((lS,3S)-3-hydroxycyclohexyl)amino)nicotinate (0.13 g, 0.44 mmol) was dissolved in DCM (6 mL) and brought to 0 °C. DAST (0.069 mL, 0.52 mmol) was then added dropwise over 1 minute. After 5 minutes the reaction mixture was quenched by the addition of saturated aqueous NaHCC>3 solution (1 mL, poured into water (5 mL) and extracted with EtOAc (3 x 5mL). The organic layers were combined, dried over MgS04, filtered and concentrated to give a crude residue which was further purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide the desired product. ES/MS: 301.4 [M+H+].
Preparation of Intermediate 1-14
Figure imgf000108_0002
(lr,4r)-4-(oxazol-5-yl)cyclohexan-l-amine hydrochloride (1-14): To a solution of tert-butyl ((lr,4r)-4-formylcyclohexyl)carbamate (500 mg, 2.2 mmol) in MeOH (10 mL) was added p-toluenesulfonylmethylisocyanide (430 mg, 2.2 mmol) and the resulting mixture heated at 65 °C for 12 hours. The mixture was poured into water (10 mL) and extracted with 2 x 20mL EtOAc. The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to give pure tert-butyl ((lr,4r)-4-(oxazol-5- yl)cyclohexyl)carbamate. This was then dissolved in HCI (4.0M in dioxane, 4 mL, 16 mmol) and stirred at room temperature for 3 hours after which the reaction mixture was concentrated to dryness directly to give 1-14 as an HCI salt which was used without further purification.
ES/MS: 167.1 [M+H] +
Preparation of Intermediate 1-15
Figure imgf000109_0001
(lr,4r)-4-(4-methyloxazol-5-yl)cyclohexan-l-amine hydrochloride (1-15): (lr,4r)-4- (4-methyloxazol-5-yl)cyclohexan-l-amine hydrochloride was prepared identically as described for 1-14 substituting p-toluenesulfonylmethylisocyanide with 1-methyl-l- tosylmethyl isocyanide.
ES/MS: 181.1 [M+H]+
Preparation of Intermediate 1-16
Figure imgf000109_0002
l-(oxazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-amine hydrochloride (1-16): l-(oxazol-5- yl)-2-oxabicyclo[2.2.2]octan-4-amine hydrochloride was prepared identically as described for 1-14 substituting tert-butyl ((lr,4r)-4-formylcyclohexyl)carbamate with tert-butyl (l-formyl-2-oxabicyclo[2.2.2]octan-4-yl)carbamate.
ES/MS: 195.1 [M+H]+
Preparation of Intermediate 1-17
Figure imgf000109_0003
l-(4-methyloxazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-amine hydrochloride (1-17): 1-
(4-methyloxazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-amine hydrochloride was prepared identically as described for 1-16 substituting p-toluenesulfonylmethylisocyanide with 1- methyl-l-tosylmethyl isocyanide.
ES/MS: 209.1 [M+H]+
Preparation of Intermediate 1-18
Figure imgf000109_0004
5-(5-nitropyridin-2-yl)oxazole: To a solution of 2-bromo-5-nitropyridine (125 mg, 0.62 mmol) in DME (2.5 niL) was added XPhos Pd G3 (43 mg, 0.051 mmol), 5-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)oxazole (132 mg, 0.68 mmol) and K3PO4 (0.5M in water, 1.5 mL, 0.77 mmol). The resulting mixture was heated in a microwave reactor at 120 °C for 20 minutes after which it was poured into water (5 mL) and extracted with EtOAc (2 x 15 mL)). The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to give 5-(5-nitropyridin-2-yl)oxazole.
ES/MS: 192.0 [M+H]+
6-(oxazol-5-yl)pyridin-3-amine (1-18): 5-(5-nitropyridin-2-yl)oxazole (178 mg, 0.093 mmol) was dissolved in THF (3 mL) after which saturated aqueous NH4C1 solution (1 mL) and iron (312 mg, 5.6 mmol) were added and the resulting mixture heated to reflux for 2 hours. The mixture was then filtered through a pad of celite which was rinsed with MeOH (5 mL), added to water (5 mL), and extracted with EtOAc (2 x 15 mL). The combined organic layers were dried over MgS04, filtered and concentrated to give 1-18 which was used without further purification.
ES/MS: 162.1 [M+H]+
Preparation of Intermediate 1-19
Figure imgf000110_0001
4-methyl-5-(5-nitropyridin-2-yl)oxazole: To a solution of 5-nitropicolinaldehyde (500 mg, 3.3 mmol) in MeOH (10 mL) was added 1 -methyl- 1-tosylmethyl isocyanide (825 mg, 3.9 mmol) and the resulting mixture heated at 65 °C for 12 hours. The mixture was poured into water (10 mL) and extracted with 2 x 20mL EtOAc. The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to give the desired product.
ES/MS: 206.1 [M+H]+
6-(4-methyloxazol-5-yl)pyridin-3-amine (1-19): 4-methyl-5-(5-nitropyridin-2- yl)oxazole (200 mg, 0.098 mmol) was dissolved in THF (3 mL) after which saturated aqueous NH4C1 solution (1 mL) and iron (327 mg, 5.8 mmol) were added and the resulting mixture heated to reflux for 2 hours. The mixture was then filtered through a pad of celite which was rinsed with MeOH (5 mL), added to water (5 mL), and extracted with EtOAc (2 x 15 mL). The combined organic layers were dried over MgS04, and concentrated to give 1-19 which was used without further purification.
ES/MS: 176.1 [M+H]+ Preparation of Intermediate 1-20
Figure imgf000111_0001
5-ethoxy-6-(oxazol-5-yl)pyridin-3-amine (1-20): To a solution of 6-bromo-5- ethoxypyridin-3 -amine (100 mg, 0.51 mmol) in DME (2 mL) was added XPhos Pd G3 (33 mg, 0.038 mmol), 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)oxazole (99 mg, 0.51 mmol) and K3PO4 (0.5M in water, 1.2 mL, 0.58 mmol). The resulting mixture was heated in a microwave reactor at 120 °C for 20 minutes after which it was poured into water (5 mL) and extracted with EtOAc (2 x 15 mL)). The combined organic layers were dried over MgS04, filtered and concentrated to give the desired product which was used without further purification.
ES/MS: 206.1 [M+H]+
Preparation of Intermediate 1-21
Figure imgf000111_0002
Benzyl (2-formylpyrimidin-5-yl)carbamate: To a solution of 2-
(diethoxymethyl)pyrimidin-5-amine (1.00 g, 5.07 mmol) in 1:1 THF:water (12 mL) was added K2CO3 (1.40 g, 10.1 mmol) and benzyl chloroformate (0.79 mL, 5.58 mmol) and the resulting mixture stirred at room temperature for 16 hours. The reaction mixture was poured into water (10 mL) and extracted with EtOAc (2 x 30 mL). The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to give the desired product which was then dissolved in acetone (10 mL) and IN HC1 (6 mL) and stirred at room temperature for 16 h. The acetone was removed by rotary evaporation and the resulting mixture partitioned between saturated aqueous NaHC03 solution (10 mL) and EtOAc (25 mL), the aqueous extracted once more with EtOAc (25 mL), and the combined organics dried over MgS04, filtered and concentrated to give benzyl (2- formylpyrimidin-5-yl)carbamate which was used without further purification.
ES/MS: 258.1 [M+H]+
Benzyl (2-(oxazol-5-yl)pyrimidin-5-yl)carbamate: To a solution of benzyl (2- formylpyrimidin-5-yl)carbamate (225 mg, 0.88 mmol) in BnOH (4 mL) was added p- toluenesulfonylmethylisocyanide (171 mg, 0.88 mmol) and the resulting mixture heated at 65 °C for 16 hours. The mixture was poured into water (10 mL) and extracted with 2 x 30mL EtOAc. The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue, still containing a significant amount of
BnOH, was purified by silica gel chromatography (eluent: EtOAc/hexanes) to give the desired product.
ES/MS: 297.2 [M+H]+
2-(oxazol-5-yl)pyrimidin-5-amine (1-21): To a solution of benzyl (2-(oxazol-5- yl)pyrimidin-5-yl)carbamate (225 mg, 0.076 mmol) in EtOH (10 mL) in a 50 mL round bottom flask was added 10% Pd/C (323 mg, 0.015 mmol). The head space was flushed with ¾ gas and an ¾ balloon then applied to the reaction flask. After 13 hours the reaction mixture was filtered through celite, rinsed with EtOH (2 x 15 mL) and the resulting EtOH solution concentrated to dryness to give crude 1-21 which was used without further purification.
ES/MS: 163.1 [M+H]+
Preparation of Intermediate 1-22
Figure imgf000112_0001
3-(oxazol-5-ylmethyl)cyclobutan-l-amine hydrochloride (1-22): 3-(oxazol-5- ylmethyl)cyclobutan-l-amine hydrochloride was prepared identically as described for I- 14 substituting tert-butyl ((lr,4r)-4-formylcyclohexyl)carbamate with the known compound tert-butyl (3-(2-oxoethyl)cyclobutyl)carbamate.
ES/MS: 153.1 [M+H]+
Preparation of Intermediate 1-23
Figure imgf000113_0001
tert-butyl ((lr,4r)-4-(hydrazinecarbonyl)cyclohexyl)carbamate: To a solution of (lr,4r)-4-((tert-butoxycarbonyl)amino)cyclohexane-l-carboxylic acid (1.5 g, 6.2 mmol) in THF (60 mL) was added CDI (1.25 g, 7.7 mmol) as a single solid portion and the resulting mixture allowed to stir at room temperature for 16 hours. Hydrazine hydrate (1.05 g, 21 mmol) was then added as a single portion and left to stir for 30 minutes after which the reaction mixture was filtered, the filter cake washed with THF (1 x 50 mL) and dried under vacuum to give the desired product which was carried forward without further purification.
ES/MS: 258.0 [M+H]+
tert-butyl ((lr,4r)-4-(l,3,4-oxadiazol-2-yl)cyclohexyl)carbamate: To a solution of tert-butyl ((lr,4r)-4-(hydrazinecarbonyl)cyclohexyl)carbamate (556 mg, 2.2 mmol) in DMF (10 mL) was added trimethyl orthoformate (1.3 mL, 12 mmol) and BF3-OEt2 (0.01 mL, 0.011 mmol) under argon. The reaction mixture was heated to 50 °C for 4 hours after which it was allowed to cool to room temperature, DIPEA (0.23 mL, 1.3 mmol) was added and the mixture allowed to stir for 12 hours. Upon completion the reaction mixture was poured into water (15 mL) and extracted with EtOAc (2 x 30 mL). The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent:
EtOAc/hexanes) to give the desired product.
ES/MS: 268.0 [M+H]+
(lr,4r)-4-(l,3,4-oxadiazol-2-yl)cyclohexan-l-amine hydrochloride (1-23): tert-butyl ((lr,4r)-4-(l,3,4-oxadiazol-2-yl)cyclohexyl)carbamate (100 mg, 0.37 mmol) was then dissolved in HCl (4.0M in dioxane, 4 mL, 16 mmol) and stirred at room temperature for 3 hours after which the reaction mixture was concentrated to dryness directly to give I- 23 as an HCl salt which was used without further purification.
ES/MS: 168.1 [M+H]+ Preparation of Intermediate 1-24
Figure imgf000114_0001
tert-butyl ((lr,4r)-4-(2-formylhydrazine-l-carbonyl)cyclohexyl)carbamate: To a solution of (lr,4r)-4-((tert-butoxycarbonyl)amino)cyclohexane-l-carboxylic acid (250 mg, 1.0 mmol) in DMF (2 mL) was added formic acid hydrazide (80 mg, 1.3 mmol), HATU (469 mg, 1.2 mmol), and finally DIPEA (0.45 mL, 2.6 mmol) and the resulting mixture stirred at room temperature for 15 minutes. Upon completion, the reaction mixture was poured into water (5 mL) and extracted with EtOAc (2 x 15 mL). The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent:
EtOAc/hexanes) to give the desired product.
ES/MS: 285.9 [M+H]+
tert-butyl ((lr,4r)-4-(l,3,4-thiadiazol-2-yl)cyclohexyl)carbamate: To a solution of tert-butyl ((lr,4r)-4-(2-formylhydrazine-l-carbonyl)cyclohexyl)carbamate (193 mg, 0.68 mmol) in dioxane (5 mL) was added Lawesson's Reagent (301 mg, 0.74 mmol) and the resulting reaction mixture heated to 100 °C for 3 hours. Upon completion, the reaction mixture was poured into water (5 mL) and extracted with EtOAc (2 x 15 mL). The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent:
EtOAc/hexanes) to give the desired product.
ES/MS: 284.0 [M+H]+
(lr,4r)-4-(l,3,4-thiadiazol-2-yl)cyclohexan-l-amine hydrochloride (1-24): tert-butyl ((lr,4r)-4-(l,3,4-thiadiazol-2-yl)cyclohexyl)carbamate (59 mg, 0.21 mmol) was then dissolved in HCl (4.0M in dioxane, 4 mL, 16 mmol) and stirred at room temperature for 7 hours after which the reaction mixture was concentrated to dryness directly to give I- 24 as an HCl salt which was used without further purification.
ES/MS: 184.1 [M+H]+
Preparation of Intermediate 1-25
O
BocHN-U
Figure imgf000114_0002
tert-butyl ((3R,6S)-6-formyltetrahydro-2H-pyran-3-yl)carbamate: To a solution of tert-butyl ((3R,6S)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)carbamate (200 mg, 0.87 mmol) in DCM (5 mL) at -10 °C was added DIPEA (2.3 mL, 13 mmol) as a single portion followed by a solution of pyridine-S03 (1:1) complex (2.1 g, 13 mmol) in DMSO (7 mL) dropwise over 2 minutes. Reaction vessel was transferred to a 0 °C bath and stirred for 1.5 hours then allowed to warm to room temperature over 2.5 hours. Reaction mixture was then brought to -10 °C, pyridine-S03 (1:1) complex (400 mg, 2.4 mmol) was added as a single portion, and the reaction mixture allowed to warm to room temperature over 2 hours. Upon completion, reaction mixture was poured into water (20 mL) and extracted with EtOAc (2 x 50 mL). The combined organic layers were washed with water (2 x 30 mL), dried over MgS04, filtered, concentrated and the resulting crude aldehyde was carried forward without further purification.
ES/MS: 230.0 [M+H]+
tert-butyl ((3R,6S)-6-(oxazol-5-yl)tetrahydro-2H-pyran-3-yl)carbamate: tert-butyl ((3R,6S)-6-formyltetrahydro-2H-pyran-3-yl)carbamate (200 mg, 0.87 mmol) in MeOH (5 mL) was added p-toluenesulfonylmethylisocyanide (170 mg, 0.87 mmol) and the resulting mixture heated at 65 °C for 14 hours. The mixture was poured into water (10 mL) and extracted with 2 x 20mL EtOAc. The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to give the desired product.
ES/MS: 269.1 [M+H]+
(3R,6S)-6-(oxazol-5-yl)tetrahydro-2H-pyran-3-amine hydrochloride (1-25): tert- butyl ((3R,6S)-6-(oxazol-5-yl)tetrahydro-2H-pyran-3-yl)carbamate (73 mg, 0.27 mmol) was then dissolved in HCI (4.0M in dioxane, 4 mL, 16 mmol) and stirred at room temperature for 6 hours after which the reaction mixture was concentrated to dryness directly to give 1-25 as an HCI salt which was used without further purification.
ES/MS: 169.1 [M+H]+
Preparation of Intermediate 1-26
cri
Figure imgf000115_0001
tert-butyl (4-(2-methyloxazol-5-yl)cyclohex-3-en-l-yl)carbamate: To a solution of 4- ((tert-butoxycarbonyl)amino)cyclohex-l-en-l-yl trifluoromethanesulfonate (150 mg, 0.43 mmol) in DME (3 mL) was added XPhos Pd G3 (18 mg, 0.022 mmol), 2-methyl-5- (4,4,5, 5-tetramethyl-l,3,2-dioxaborolan-2-yl)oxazole (109 mg, 0.52 mmol) and K3PO4 (0.5M in water, 1.3 mL, 0.65 mmol). The resulting mixture was heated in a microwave reactor at 120 °C for 20 minutes after which it was poured into water (5 mL) and extracted with EtOAc (2 x 15 mL)). The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to give the desired product.
ES/MS: 279.2 [M+H]+
tert-butyl (4-(2-methyloxazol-5-yl)cyclohexyl)carbamate: To a solution of tert-butyl (4-(2-methyloxazol-5-yl)cyclohex-3-en-l-yl)carbamate (140 mg, 0.50 mmol) in EtOH (6 mL) in a 50 mL round bottom flask was added 10% Pd/C (107 mg, 0.10 mmol). The head space was flushed with ¾ gas and an ¾ balloon then applied to the reaction flask. After 2 hours the reaction mixture was filtered through celite, rinsed with EtOH (2 x 15 mL) and the resulting EtOH solution concentrated to dryness to give the desired product which was used without further purification.
ES/MS: 281.2 [M+H]+
4-(2-methyloxazol-5-yl)cyclohexan-l-amine hydrochloride (1-26): tert-butyl (4-(2- methyloxazol-5-yl)cyclohexyl)carbamate (141 mg, 0.50 mmol) was then dissolved in
HCl (4.0M in dioxane, 4 mL, 16 mmol) and stirred at room temperature for 2 hours after which the reaction mixture was concentrated to dryness directly to give 1-26 as an HCl salt which was used without further purification.
ES/MS: 181.1 [M+H]+
Preparation of Intermediate 1-27
Figure imgf000116_0001
Methyl N,N-dibenzyl-0-(tert-butyldimethylsilyl)-L-serinate: To a solution of methyl dibenzyl-L-serinate (2.0 g, 10 mmol) in DCM (10 mL) was added TBS-CI (1.7 g, 11 mmol), DMAP (61 mg, 0.50 mmol) and DIPEA (3.5 mL, 20 mmol) and the resulting solution stirred at room temperature for 3 hours. Upon completion, the reaction mixture was poured into water (20 mL) and extracted with DCM (2 x 20mL). The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to give the desired product.
ES/MS: 414.4 [M+H]+
(S)-l-(2-((tert-butyldimethylsilyl)oxy)-l-(dibenzylamino)ethyl)cyclopropan-l-ol: To a solution of methyl N,N-dibenzyl-0-(tert-butyldimethylsilyl)-L-serinate (500 mg, 1.1 mmol) in THF (8 mL) at 0 °C was added Ti(OEt)4 (0.11 mL, 0.36 mmol) followed by the dropwise addition of a solution of EtMgBr (3.0M in Et20, 1.2 mL, 3.6 mmol) diluted with THF to a total volume of 4 mL. After 16 hours of stirring Ti(OEt)4 (0.29 mL, 0.97 mmol) was added followed by the dropwise addition of a solution of EtMgBr (3.0M in Et20, 1.2 mL, 3.6 mmol) diluted with THF to a total volume of 4 mL. After 20 minutes the starting ester was fully consumed and the reaction quenched with the careful addition of saturated aqueous NH^Cl solution (5 mL), EtOAc was added (20 mL) and the reaction mixture stirred vigorously for 20 minutes. The reaction mixture was poured into water (20 mL) and extracted with EtOAc (2 x 40mL). The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to give the desired product.
ES/MS: 412.5 [M+H]+
(S)-2-(l-(benzyloxy)cyclopropyl)-2-(dibenzylamino)ethan-l-ol: To a solution of (S)- 1 -(2-((tert-butyldimethylsilyl)oxy)- 1 -(dibenzylamino)ethyl)cyclopropan- 1 -ol (349 mg, 0.85 mmol) in THF (8 mL) at 0 °C was added NaH (60% dispersion in mineral oil, 102 mg, 2.5 mmol) then benzyl bromide (0.12 mL, 1.0 mmol) after which the reaction mixture was allowed to warm to room temperature over 2 hours. Benzyl bromide (1.0 mL, 8.5 mmol) and TBAI (63 mg, 0.17 mmol) were added as single portions and the resulting reaction mixture stirred for 16 hours. Upon completion the reaction mixture was poured into water (20 mL) and extracted with EtOAc (2 x 40mL). The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to give (S)- N,N-dibenzyl-l-(l-(benzyloxy)cyclopropyl)-2-((tert-butyldimethylsilyl)oxy)ethan-l- amine (425 mg, 0.85 mmol) which was then dissolved in THF (5 mL) at room temperature and treated with TBAF (1.0M in THF, 1.0 mL, 1.0 mmol). After 24 hours the reaction mixture was poured into water (5 mL) and extracted with EtOAc (2 x 15 mL). The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent:
EtOAc/hexanes) to give the desired product.
ES/MS: 388.4 [M+H]+
(R)-l-(2-amino-l-fluoroethyl)cyclopropan-l-ol (1-27): To a solution of (S)-2-(l- (benzyloxy)cyclopropyl)-2-(dibenzylamino)ethan-l-ol (328 mg, 0.85 mmol) in THF (6 mL) in a Teflon vial was added (diethylamino)sulfur trifluoride (0.14 mL, 1.0 mmol) dropwise at 0 °C. The reaction mixture was allowed to warm to room temperature over 4 hours after which it was poured into saturated aqueous NaHCC>3 solution (10 mL) and extracted with EtOAc (2 x 25 mL). The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent: EtOAc/hexanes) to give (R)-N,N-dibenzyl-2-(l- (benzyloxy)cyclopropyl)-2-fluoroethan-l-amine. To a solution of (R)-N,N-dibenzyl-2- (l-(benzyloxy)cyclopropyl)-2-fluoroethan-l-amine (330 mg, 0.85 mmol) in EtOH (8 mL) and EtOAc (2 mL) in a 50 mL round bottom flask was added 10% Pd/C (270 mg, 0.25 mmol). The head space was flushed with ¾ gas and an ¾ balloon then applied to the reaction flask. After 16 hours the reaction mixture was filtered through celite, rinsed with EtOH (2 x 15 mL) and the resulting EtOH solution concentrated to dryness to give 1-27 which was used without further purification.
ES/MS: 120.1 [M+H]+
Preparation of Intermediate 1-28
Figure imgf000118_0001
I-28C 1-28 tert-butyl 3,3-difluoro-4-(((trifluoromethyl)sulfonyl)oxy)pyrrolidine-l-carboxylate (I-28B):
To a solution of tert-butyl 3,3-difluoro-4-hydroxypyrrolidine-l-carboxylate (I-28A, 939 mg, 4.188 mmol) in DCM (40 mL) at -10 °C, was added pyridine (2.2 ml, 21.35 mmol). Trifluoromethanesulfonic anhydride (1M solution in methylene chloride, 10.5 ml) was added via addition funnel over -10 min. Stirred an additional 2 hr at -10 °C. The reaction was quenched with 1 M citric acid to pH 4.5 (~5 mL). The organic layer was separated, and the aqueous was extracted with DCM. The combined organic extracts were dried over sodium sulfate to give I-28B.
1H NMR (400 MHz, Chloroform-d) δ 5.16 (s, 1H), 4.05 - 3.65 (m, 4H), 1.48 (s, 9H) 19F NMR (376 MHz, Chloroform-d) δ -75.01 (d, J = 33.7 Hz), -78.87, -108.16 (dd, J = 246.8, 81.5 Hz), -120.31 (dd, J = 308.9, 247.6 Hz). tert-butyl 3,3-difluoro-4-(4-nitro-lH-pyrazol-l-yl)pyrrolidine-l-carboxylate (I- 28C):
To a solution of 4-nitro-lH-pyrazole (I-28C , 250 mg, 2.211 mmol) in DMF (5 mL) at 0 °C, was added sodium hydride , 60% disp. in oil (138 mg, 3.45 mmol). After stirring for 1 hr, added a solution of tert-butyl 3,3-difluoro-4-
(((trifluoromethyl)sulfonyl)oxy)pyrrolidine-l-carboxylate (I-28B, 943 mg, 2.653 mmol) in 5 mL DMF and heated at 95 °C overnight. The reaction mixture was diluted with EtOAc and washed with brine twice. The organic extract was dried over sodium sulfate and purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide I-28C. 1H NMR (400 MHz, Chloroform-d) δ 8.16 (s, 1H), 8.13 - 8.01 (m, 1H), 4.89 (p, J = 5.7 Hz, 1H), 3.87 (dd, J = 12.0, 6.5 Hz, 1H), 3.77 (s, 1H), 3.57 (s, 2H), 2.60 - 2.34 (m, 2H), 1.48 (s, 9H). tert-butyl 4-(4-amino-lH-pyrazol-l-yl)-3,3-difluoropyrrolidine-l-carboxylate (1-28): A solution of tert-butyl 3,3-difluoro-4-(4-nitro-lH-pyrazol-l-yl)pyrrolidine-l- carboxylate (I-28C, 165 mg, 0.518 mmol) in EtOH (15 mL) was degassed with argon and vacuum. Added Pd/C (10%, 28 mg, 0.026 mmol) and stirred with a balloon of hydrogen for 2 d. The reaction was filtered over a Celite plug, rinsed with EtOAc and the filtrate was concentrated to give 1-28.
ES/MS: 288.9 (M+).
1H NMR (400 MHz, Chloroform-d) δ 7.30 (s, 1H), 7.20 (d, J = 5.8 Hz, 1H), 4.92 - 4.69 (m, 1H), 4.01 (dd, J = 13.6, 6.5 Hz, 2H), 3.95 - 3.76 (m, 2H), 1.47 (d, J = 3.8 Hz, 9H).
Preparation of Intermediate 1-29
Figure imgf000120_0001
1-29
tert-butyl (3R,4R)-3-(4-amino-lH-pyrazol-l-yl)-4-fluoropyrrolidine-l-carboxylate was prepared similarly to 1-28, but substituting tert-butyl 3,3-difluoro-4-hydroxypyrrolidine- 1-carboxylate with tert-butyl (3R,4S)-3-fluoro-4-hydroxypyrrolidine- 1-carboxylate in the first step.
ES/MS: 270.9 (M+).
1H NMR (400 MHz, Chloroform-d) δ 7.29 (s, 1H), 7.13 (d, J = 15.0 Hz, 1H), 5.26 (dd, J = 50.9, 21.6 Hz, 1H), 4.82 (d, J = 14.0 Hz, 1H), 4.06 - 3.38 (m, 6H), 1.49 (s, 9H).
19F NMR (376 MHz, Chloroform-d) δ -177.64, -182.29 (m)
Preparation of Intermediate 1-30
Figure imgf000120_0002
1-30
tert-butyl (3R,4S)-3-(4-amino-lH-pyrazol-l-yl)-4-fluoropyrrolidine-l-carboxylate was prepared similarly to 1-28, but substituting tert-butyl 3,3-difluoro-4-hydroxypyrrolidine- 1-carboxylate with tert-butyl (3S,4S)-3-fluoro-4-hydroxypyrrolidine-l-carboxylate in the first step.
ES/MS: 271.9 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 7.21 (d, J = 14.5 Hz, 2H), 5.23 (ddd, J = 53.9, 7.0, 3.6 Hz, 1H), 4.84 (d, J = 27.9 Hz, 1H), 4.04 (dt, J = 15.3, 9.5 Hz, 1H), 3.99 - 3.59 (m, 3H), 2.73 (s, 2H), 1.50 (s, 9H).
19F NMR (376 MHz, Chloroform-d) δ -179.08. -204.08 (m)
Preparation of Intermediate 1-31
Figure imgf000120_0003
1-31 tert-butyl (3S,4R)-3-(4-amino-lH-pyrazol-l-yl)-4-fluoropyrrolidine-l-carboxylate was prepared similarly to 1-28, but substituting tert-butyl 3,3-difluoro-4-hydroxypyrrolidine- 1-carboxylate with tert-butyl (3R,4R)-3-fluoro-4-hydroxypyrrolidine-l-carboxylate in the first step.
ES/MS: 270.9 (M+).
1H NMR (400 MHz, Chloroform-d) δ 7.21 (d, J = 14.1 Hz, 2H), 5.47 - 5.04 (m, 1H), 5.00 - 4.71 (m, 1H), 4.18 - 3.99 (m, 1H), 3.99 - 3.52 (m, 2H), 2.73 (s, 2H), 1.50 (s, 9H). 19F NMR (376 MHz, Chloroform-d) δ -193.69 (ddd, J = 60.6, 32.8, 24.6 Hz). Preparation of Intermediate 1-32
Figure imgf000121_0001
I-32C 1-32
2-chloroethyl (2-(4-nitrophenyl)propan-2-yl)carbamate (EC-I-5B) :
To a solution of 2-(4-nitrophenyl)propan-2-amine (250 mg, 1.154 mmol) and N,N- diisopropylethylamine (0.5 ml, 2.87 mmol) in DCM (5 mL) at 0 °C, was added 2- chloroethyl carbonochloridate (0.15 ml, 1.45 mmol).The reaction was gradually warmed to rt and stirred for 2 hr. The reaction was diluted with DCM and washed with IN HCl and brine. The organic extract was dried over sodium sulfate to give I-32B. 3-(2-(4-nitrophenyl)propan-2-yl)oxazolidin-2-one (I-32C):
To a solution of 2-chloroethyl (2-(4-nitrophenyl)propan-2-yl)carbamate (I-32B, 330.8 mg, 1.154 mmol) in CH3CN (5 mL), was added l,8-diazabicyclo[5.4.0]undec-7-ene (0.85 ml, 5.69 mmol). The reaction was heated at 80 °C for 3 hr. The reaction was diluted with EtOAc and washed with IN HCl and brine. The organic extract was dried over sodium sulfate to give I-32C. ES/MS: 251.0 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 8.24 - 8.15 (m, 2H), 7.60 - 7.51 (m, 2H), 4.34 (dd, J = 8.5, 7.2 Hz, 2H), 3.72 - 3.63 (m, 2H), 1.74 (s, 6H).
3-(2-(4-aminophenyl)propan-2-yl)oxazolidin-2-one (1-32):
To a suspension of 3-(2-(4-nitrophenyl)propan-2-yl)oxazolidin-2-one (I-32C, 278 mg, 1.111 mmol) in EtOH (20 mL), was added calcium chloride (185 mg, 1.667 mmol) and iron powder (326 mg, 5.838 mmol). Added 2 mL water and heated the reaction mixture to 60 °C overnight. The reaction was filtered through a Celite plug and washed with EtOAc. The filtrate was washed with saturated NaHC03 solution and brine and dried over sodium sulfate to give product 1-32
1H NMR (400 MHz, Chloroform-d) δ 7.19 (d, J = 8.6 Hz, 2H), 6.65 (d, J = 8.6 Hz, 2H), 4.26 - 4.07 (m, 2H), 3.47 - 3.23 (m, 2H), 1.74 (s, 6H).
Preparation of Intermediate 1-33
Figure imgf000122_0001
1-33
3-(l-(4-aminophenyl)cyclopropyl)oxazolidin-2-one (1-33):
3-(l-(4-aminophenyl)cyclopropyl)oxazolidin-2-one was prepared similarly to 1-32, but substituting 2-(4-nitrophenyl)propan-2-amine with l-(4-nitrophenyl)cyclopropan-l- amine in the first step.
ES/MS: 219.1 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 7.23 - 7.17 (m, 2H), 6.68 - 6.58 (m, 2H), 4.21 (dd, J = 8.8, 7.3 Hz, 2H), 3.56 - 3.43 (m, 2H), 1.36 - 1.23 (m, 2H), 1.20 - 1.06 (m, 2H).
Preparation of Intermediate 1-34
Figure imgf000122_0002
1-34
l-(2-(4-aminophenyl)propan-2-yl)pyrrolidin-2-one (1-34): l-(2-(4-aminophenyl)propan-2-yl)pyrrolidin-2-one was prepared similarly to 1-32, but substituting 2-chloroethyl carbonochloridate with 4-chlorobutanoyl chloride in the first step.
ES/MS: 218.9 (M+).
1H NMR (400 MHz, Chloroform-d) δ 7.12 (d, J = 8.5 Hz, 2H), 6.63 (d, J = 8.6 Hz, 2H), 3.69 (d, J = 20.0 Hz, 2H), 3.30 (t, J = 7.0 Hz, 2H), 2.36 (t, J = 8.1 Hz, 2H), 1.89 (tt, J = 7.7, 6.8 Hz, 2H), 1.72 (s, 6H).
Preparation of Intermediate 1-35
Figure imgf000123_0001
I-35A I-35B I-35C 1-35
3-(5-nitropyrimidin-2-yl)-6-oxa-3-azabicyclo[3.1.1]heptane (I-35C):
To a solution of 2-chloro-5-nitropyrimidine (0.200 g, 1.254 mmol) and 6-oxa-3- azabicyclo[3.1.1]heptane 4-methylbenzenesulfonate (0.394 g, 1.452 mmol) in 2Me-THF (6 mL), was added triethylamine (0.4 ml, 2.870 mmol). The reaction was stirred at rt overnight. The reaction was partitioned with DCM and water. The organic extract washed with brine and dried over sodium sulfate to give I-35C.
ES/MS: 223.0.9 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 9.18 (s, 1H), 4.80 (d, J = 6.6 Hz, 2H), 4.08 (d, J = 13.8 Hz, 2H), 3.97 (d, J = 13.9 Hz, 2H), 3.37 (q, J = 7.4 Hz, 1H), 1.95 (d, J = 9.2 Hz, 1H).
2-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)pyrimidin-5-amine (1-35)
A solution of 3-(5-nitropyrimidin-2-yl)-6-oxa-3-azabicyclo[3.1.1]heptane (I-35C, 264 mg, 1.263 mmol) in EtOH (15 mL) was degassed with argon and vacuum. Added Pd/C (10%, 66 mg, 0.062 mmol) and stirred with a balloon of hydrogen overnight. The reaction was filtered over a Celite plug, rinsed with EtOAc and the filtrate was concentrated to give 1-35.
ES/MS: 193.1 (M+H+). 1H NMR (400 MHz, Chloroform-d) δ 8.05 (s, 2H), 4.74 (d, J = 6.5 Hz, 2H), 3.98 - 3.69 (m, 5H), 3.26 (q, J = 7.2 Hz, 1H), 3.18 (s, 2H), 1.99 (d, J = 8.7 Hz, 1H).
Preparation of Intermediate 1-36
Figure imgf000124_0001
3-(5-nitropyridin-2-yl)-6-oxa-3-azabicyclo[3.1.1]heptane (I-36C):
To a solution of 2-chloro-5-nitropyridine (I-36A, 0.200 g, 1.261 mmol) and
6-oxa-3-azabicyclo[3.1.1]heptane 4-methylbenzenesulfonate (I-36B, 0.396 g, 1.461 mmol) in 2Me-THF (6 mL), was added triethylamine (0.4 ml, 2.870 mmol). The reaction was stirred at rt. Added 321 mg of I-36B and trimethylamine (0.4 mL) and heated at 50 °C for 2 d.
The reaction was partitioned with DCM and water. The organic extract washed with brine and dried over sodium sulfate to give I-36C.
ES/MS: 222.1 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 9.14 (d, J = 2.7 Hz, 1H), 8.31 (dd, J = 9.5, 2.7 Hz, 1H), 6.55 (d, J = 9.5 Hz, 1H), 4.83 (d, J = 6.6 Hz, 2H), 4.34 - 3.52 (m, 4H), 3.37 (dt, J = 9.4, 6.8 Hz, 1H), 1.98 (d, J = 9.1 Hz, 1H). 6-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)pyridin-3-amine (1-36):
A solution of 3-(5-nitropyridin-2-yl)-6-oxa-3-azabicyclo[3.1.1]heptane (I-36C, 245 mg, 1.108 mmol) in EtOH (15 mL) was degassed with argon and vacuum. Added Pd/C (10%, 60 mg, 0.056 mmol) and stirred with a balloon of hydrogen overnight. The reaction was filtered over a Celite plug, rinsed with EtOAc and the filtrate was concentrated to give I- 36.
ES/MS: 192.2 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 7.84 (d, J = 2.9 Hz, 1H), 7.07 (dd, J = 8.7, 2.9 Hz, 1H), 6.46 (d, J = 8.9 Hz, 1H), 4.76 (d, J = 6.6 Hz, 2H), 3.80 - 3.61 (m, 5H), 3.26 (q, J = 7.1 Hz, 1H), 2.05 (d, J = 8.6 Hz, 1H).
Figure imgf000125_0001
Pyrrolo[l,2-b]pyridazine: To a solution of lH-pyrrol-1 -amine (500 mg, 6.09 mmol) in acetic acid (4 mL) was added (E)-3-(dimethylamino)acrylaldehyde (0.7 mL, 7 mmol). The resulting mixture was stirred at room temperature for 18 hours and diluted with CH2CI2. The organic layer was washed with water and aqueous, saturated NaHCC>3. The aqueous layers were back-extracted with CH2CI2 and the resulting organic layers were dried over MgS04 and carefully concentrated. The resulting yellow oil was purified by bulb-to-bulb distillation to provide the product.
ES/MS: 119.0 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 8.05 - 7.99 (m, 1H), 7.81 - 7.69 (m, 2H), 6.88 (dd, J = 4.3, 2.7 Hz, 1H), 6.52 (dd, J = 9.2, 4.3 Hz, 2H).
7-Bromopyrrolo[l,2-b]pyridazine (1-37) To a solution of pyrrolo[l,2-b]pyridazine (100 mg, 0.85 mmol) in CH2C12 (1.5 mL) and acetonitrile (0.5 mL) at 0 °C was added N- bromosuccinimide (150 mg, 0.84 mmol). The mixture was stirred at 0 °C for 10 min and loaded directly onto a S1O2 column for purification (eluent: EtOAc / hexanes) to provide the desired product.
ES/MS: 199.0 (M+H+).
Preparation of Intermediate 1-38
Figure imgf000125_0002
Methyl 6-chloro-4-((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinate (1-38): To a solution of methyl 4,6-dichloronicotinate (870 mg, 4.22 mmol) and 1- aminobicyclo[2.2.2]octan-4-ol hydrochloride (500 mg, 2.81 mmol) in butyronitrile (12 mL) was added cesium carbonate (1.98 g, 6.08 mmol). The resulting slurry was heated to 120 °C for 24 hours. The mixture was cooled, diluted with EtOAc, and filtered. The solids were washed with EtOAc and the combined filtrates were concentrated and purified by S1O2 chromotography (eluent: 2-5% MeOH/CI¾Cl2) to provide the desired product.
ES/MS: 311.3 (M+H+).
Preparation of Intermediate 1-39
Figure imgf000126_0001
4-(3,3-difluoropyrrolidin-l-yl)cyclohexan-l-amine hydrochloride (1-39):
To a suspension of tert-butyl (4-oxocyclohexyl)carbamate ( 0.5 g, 2.34 mmol), 3,3- Difluoropyrrolidine hydrochloride ( 0.37 g, 2.56 mmol), acetic acid ( 0.21 g, 3.5 mmol), and Sodium triacetoxyborohydride ( 0.75 g, 3.5 mmol) in MeOH ( 3 mL) and DCE ( 6 mL), was stirred for overnight. Diluted with EtOAc and washed with sodium bicarbonate saturated solution. The organic layer was dried and concentrated. Used without further purification.
ES/MS: 205 (M+H+). Preparation of Intermediate 1-40
Figure imgf000126_0002
I tert-butyl ((lr,3r)-3-((2-oxopyridin-l(2H)-yl)methyl)cyclobutyl)carbamate:
To a solution of tert-butyl ((lr,3r)-3-(hydroxymethyl)cyclobutyl)carbamate ( 0.62 g, 3 mmol), trimethylamine ( 0.86 mL, 6 mmol) and 4-(Dimethylamino)pyridine ( 38 mg, 0.3 mmol) in DCM ( 5 mL), Methanesulfonic anhydride ( 0.64 g, 4 mmol) was added to the solution. It was stirred for 16 hours then diluted with EtOAc and washed with NaHC03 (sat.). The organic layer was dried and concentrated. The crude mixture and 2- Hydroxypyridine and Potassium carbonate ( 0.74 g, 5 mmol) were dissolved in DMSO. It was heated at 70 °C for 16 hours. Cooled it down and filtered. The filtrate was purified on RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product.
ES/MS: 279 (M+H+). l-(((lr,3r)-3-aminocyclobutyl)methyl)pyridin-2(lH)-one hydrochloride (1-40): tert-butyl ((lr,3r)-3-((2-oxopyridin-l(2H)-yl)methyl)cyclobutyl)carbamate ( 250 mg, 0.9 mmol) was dissolved in 3 mL of 4M HCI in dioxane. After 2 hours, the solvent was removed. Used without further purification.
Preparation of Intermediate 1-41
Figure imgf000127_0001
tert-butyl (R)-(2-fluoro-3-((methylcarbamoyl)oxy)propyl)carbamate:
To a solution of tert-butyl (R)-(2-fluoro-3-hydroxypropyl)carbamate ( 170 mg, 0.88 mmol) 4-nitrophenyl carbonochloridate ( 710 mg, 3.5 mmol) and 4- (Dimethylamino)pyridine ( 430 mg, 3.5 mmol) in DCM (5 mL) and pyridine ( 5 mL), was stirred at r.t. for overnight. Methylamine was added to the mixture and the resulting mixture stirred. Upon completion the solvent was removed and the crude material was purified RP-HPLC (eluent: water / MeCN *0.1 % TFA) to yield the product.
ES/MS: 251 (M+H+).
(R)-3-amino-2-fluoropropyl methylcarbamate hydrochloride (1-41): tert-butyl (R)-(2-fluoro-3-((methylcarbamoyl)oxy)propyl)carbamate was dissolved in 4M HCI in dioxane, was stirred for 2 hours. The solvent was removed and resulting material used without further purification. Preparation of Intermediate 1-42
Figure imgf000128_0001
tert-butyl (3-(azidomethyl)-3-hydroxycyclobutyl)carbamate:
To a flask of tert-butyl (3-hydroxy-3-(hydroxymethyl)cyclobutyl)carbamate ( 1.8 g, 8 mmol) and N-ethyldiisopropylamine ( 3.6 mL, 21 mmol) in DCM ( 20 mL), methanesulfonic anhydride ( 1.59 g, 9 mmol) was added and stirred overnight. The mixture was diluted with EtOAc and washed with saturated NaHCC>3 and brine. The organic layer was dried and concentrated. The mixture was dissolved in DMF and sodium azide ( 1.58 g, 24 mmol) was added to the suspension. It was stirred at 65 °C for 8 hours then diluted with EtOAc and washed with saturated NaHCC>3 and brine. The organic layer was dried and concentrated. Used without further purification.
ES/MS: 243 (M+H+). methyl ((3-amino-l-hydroxycyclobutyl)methyl)carbamate hydrochloride:
To a solution of tert-butyl (3-(azidomethyl)-3-hydroxycyclobutyl)carbamate ( 2 g, 8.3 mmol), triphenylphosphine ( 3.2 g, 12 mmol) and ammonium hydroxide (4.6 mL, 33 mol) in THF (15 mL)/ MeOH (15 mL)/ ¾0 (3 mL), was stirred for overnight at room temperature. The solids were filtered and the filtrate was concentrated. The residue was dissolved in 20 mL of DCM, trimethylamine ( 4.8 mL, 34 mmol) and methyl chloroformate ( 1.1 mL, 14 mmol) was added to the mixture. It was stirred for 1 hour. MeOH (3 mL) was added and the solvent removed. The mixture was purified by S1O2 flash column (eluent: EtOAc/Hexane). The product was dissolved in 2 mL of 4 N HCl in dioxane. After 1 hour, the solvent was removed. Used without further purification. methyl (((lS,3s)-3-((2-chloro-5-(((R)-2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)-l- hydroxycyclobutyl)methyl)carbamate: methyl (((lR,3r)-3-((2-chloro-5-(((R)-2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)-l- hydr oxycyclobutyl)methyl)carbamate :
(R)-4,6-dichloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide ( 25 mg, 0.09 mmol) and methyl ((3-amino-l-hydroxycyclobutyl)methyl)carbamate hydrochloride ( 36 mg, 0.17 mmol) and N-ethyldiisopropylamine ( 0.06 mL, 0.34 mmol) in 1 mL of MeCN. The mixture was heated at 80 °C for 24 hours. The solvent was removed, then purified by RP-HPLC (eluent: water / MeCN *0.1 % TFA).
ES/MS: 433.4 (M+H+).
ES/MS: 433.4 (M+H+).
Preparation of Intermediate 1-43
Figure imgf000129_0001
ethyl 6-chloro-4-((3-hydroxy-3-
(((methoxycarbonyl)amino)methyl)cyclobutyl)amino)nicotinate:
To a flask of ethyl 4,6-dichloronicotinate ( 0.8 g, 3.6 mmol and methyl ((3-amino-l- hydroxycyclobutyl)methyl)carbamate hydrochloride ( 1.25 g, 5.4 mmol) and N- ethyldiisopropylamine ( 1.9 mL, 10.9 mmol) in 10 mL of MeCN. The mixture was heated at 60 °C for 24 hours. The solvent was removed, then purified by RP-HPLC (eluent: water / MeCN *0.1% TFA). The product fractions were combined and neutralized with saturated NaHCC>3 solution to give product.
ES/MS: 358.7 (M+H+). ethyl 6-chloro-4-((3-fluoro-3-
(((methoxycarbonyl)amino)methyl)cyclobutyl)amino)nicotinate (1-43):
To a flask of ethyl 6-chloro-4-((3-hydroxy-3-
(((methoxycarbonyl)amino)methyl)cyclobutyl)amino)nicotinate ( 500 mg, 1.4 mmol) in 5 mL of DCM, bis(2-methoxyethyl)aminosulfur trifluoride ( 0.3 mL, 1.7 mmol) was added to the solution. It was stirred for 20 minutes. Diluted with EtOAc and washed with saturated NaHCC>3 and brine. The organic layer was dried and concentrated, then purified by RP-HPLC (eluent: water / MeCN *0.1% TFA).
ES/MS: 360.3 (M+H+).
Preparation of Intermediate 1-44
Figure imgf000130_0001
ethyl 6-chloro-4-((3-hydroxy-3-(hydroxymethyl)cyclobutyl)amino)nicotinate:
To a flask of ethyl 4,6-dichloronicotinate ( 0.58 g, 2.6 mmol) and 3-amino-l- (hydroxymethyl)cyclobutan-l-ol ( 0.81 g, 5.3 mmol) and N-ethyldiisopropylamine ( 1.8 mL, 10.5 mmol) in 5 mL of MeCN. The mixture was heated at 80 °C for 48 hours. The solvent was removed, then purified by RP-HPLC (eluent: water / MeCN *0.1% TFA). The product fractions were combined and neutralized with saturated NaHC03 solution to give product.
ES/MS: 301.2 (M+H+). ethyl 4-((3-(azidomethyl)-3-hydroxycyclobutyl)amino)-6-chloronicotinate:
To a flask of ethyl 6-chloro-4-((3-hydroxy-3-
(hydroxymethyl)cyclobutyl)amino)nicotinate ( 0.75 g, 2 mmol) and N- ethyldiisopropylamine ( 1.1 mL, 6 mmol) in DCM ( 5 mL), p-Toluenesulfonic anhydride ( 1.63 g, 5 mmol) was added to the solution. It was stirred for overnight. Diluted with EtOAc and washed with saturated NaHC03 and brine. The organic layer was dried and concentrated. The residue was dissolved in DMF and sodium azide ( 0.53 g, 8 mmol) was added to the suspension. It was stirred at 65 °C for 8 hours. Diluted with EtOAc and washed with saturated NaHC03 and brine. The organic layer was dried and concentrated. Used without further purification.
ES/MS: 326.3 (M+H+). ethyl 6-chloro-4-((6-oxo-5-oxa-7-azaspiro[3.4]octan-2-yl)amino)nicotinate (1-44):
To a solution of ethyl 4-((3-(azidomethyl)-3-hydroxycyclobutyl)amino)-6- chloronicotinate ( 0.6 g, 1.84 mmol), triphenylphosphine ( 0.73 g, 2.8 mmol) and ammonium hydroxide (1 mL, 7 mol) in THF (5 mL)/ MeOH (5 mL)/ H20 (1 mL), was stirred for overnight. The solids were filtered and the filtrate was concentrated. The residue was dissolved in 10 mL of DCM and Ι,Γ-Carbonyldiimidazole ( 272 mg, 2 mmol) was added to the mixture. It was stirred for 16 hours, diluted with EtOAc and washed with 20 mL of 0.5 N HCI twice. The organic layer was dried and concentrated. The mixture was purified on flash column (50% EtOAc/Hexane).
ES/MS: 326.2 (M+H+).
Preparation of Intermediate 1-45
Figure imgf000131_0001
tert-butyl ((lr,4r)-4-(5-(trimethylsilyl)isoxazol-3-yl)cyclohexyl)carbamate:
To a solution of tert-butyl ((lr,4r)-4-formylcyclohexyl)carbamate ( 0.5 g, 2.2 mmol) in methanol (10 mL) and water (9 mL) was added NH2OH-HCl ( 0.2 g, 2.9 mmol). Then, 2.9 mL of IN sodium hydroxide was added. The reaction mixture was stirred at r.t. for overnight. Water (30 mL) was added, the precipitate filtered off and washed with water to give the white solid. The solid and trimethylsilylacetylene (0.62 mL, 4.4 mmol) in THF, 2.1 mL of 13% sodium hypochlorite solution was added to the solution. It was stirred for 16 hours. Diluted with EtOAc and washed with saturated Na2S2(¾. The organic layer was dried and concentrated, and purified by flash column (eluent:
EtOAc/Hexane).
ES/MS: 338.9 (M+H+).
(lr,4r)-4-(isoxazol-3-yl)cyclohexan-l-amine hydrochloride (1-45):
To a solution of tert-butyl ((lr,4r)-4-(5-(trimethylsilyl)isoxazol-3- yl)cyclohexyl)carbamate ( 0.45 g, 1 mmol) in 4 mL of EtOH and 1.5 mL of 28%
NH40H , was stirred for 16 hours. Removed the solvent and purified by flash column (eluent: EtOAc/Hexane). The product was collected and dissolved in 5 mL of 4M HCl in dioxane. The mixture was stirred for 3 hours. Removed the solvent and dried in the vacuum. Used without further purification.
Preparation of Intermediate 1-46
Figure imgf000132_0001
ethyl 6-chloro-4-(((lr,3r)-3-(hydroxymethyl)cyclobutyl)amino)nicotinate:
A solution of ethyl 4,6-dichloronicotinate ( 0.45 g, 2 mmol) and ((lr,3r)-3- aminocyclobutyl)methanol ( 0.56 g, 4 mmol) and N-ethyldiisopropylamine ( 1.4 mL, 8 mmol) in 5 mL of MeCN was heated at 80 °C for 16 hours. The solvent was removed, then purified by RP-HPLC (eluent: water / MeCN *0.1% TFA).
ES/MS: 285.3 (M+H+). ethyl 6-chloro-4-(((lr,3r)-3-((tosyloxy)methyl)cyclobutyl)amino)nicotinate:
To a flask of ethyl 6-chloro-4-(((lr,3r)-3-(hydroxymethyl)cyclobutyl)amino)nicotinate ( 0.58 g, 2 mmol) and N-ethyldiisopropylamine ( 0.89 mL, 5 mmol) in DCM ( 5 mL), p- Toluenesulfonic anhydride ( 1.33 g, 4 mmol) was added to the solution. It was stirred for overnight then diluted with EtOAc and washed with saturated NaHC03 and brine. The organic layer was dried and concentrated. The solvent was removed, then purified by RP-HPLC (eluent: water / MeCN *0.1% TFA). The product fractions were combined and neutralized with saturated NaHCC>3 solution to give product.
ES/MS: 439.5 (M+H+). ethyl 4-(((lr,3r)-3-((lH-l,2,4-triazol-l-yl)methyl)cyclobutyl)amino)-6- chloronicotinate (1-46):
To a suspension of 1,2,4-triazole ( 28 mg, 0.4 mmol) and 60% of sodium hydride ( 14.6 mg, 0.36 mmol) in 1 mL of NMP, ethyl 6-chloro-4-(((lr,3r)-3-
((tosyloxy)methyl)cyclobutyl)amino)nicotinate ( 100 mg, 0.23 mmol) was added to the suspension after 10 minutes. The mixture was stirred for 16 hours then diluted with EtOAc and washed with brine. The organic layer was dried and concentrated. The mixture was purified purified by RP-HPLC (eluent: water / MeCN *0.1% TFA).
ES/MS: 336.2 (M+H+). Preparation of Intermediate 1-47
Figure imgf000134_0001
ethyl 4-((4-aminobicyclo[2.2.2]octan-l-yl)amino)-6-chloronicotinate hydrochloride:
To a flask of ethyl 4,6-dichloronicotinate ( 1 g, 5 mmol) and tert-butyl (4- aminobicyclo[2.2.2]octan-l-yl)carbamate ( 2.18 g, 9 mmol) and N- ethyldiisopropylamine ( 1.58 mL, 9 mmol) in 3 mL of NMP. The mixture was heated at 90 °C for 16 hours. The solvent was removed and purified by flash column (eluent: EtOAc/Hexane). The product was collected and dissolved in 20 mL of 4 M HC1 in dioxane. The mixture was stirred for 2 hours. The solvent was removed and used without further purification.
ES/MS: 324.3 (M+H+). ethyl 6-chloro-4-((4-morpholinobicyclo[2.2.2]octan-l-yl)amino)nicotinate (1-47):
To a solution of ethyl 4-((4-aminobicyclo[2.2.2]octan-l-yl)amino)-6-chloronicotinate hydrochloride ( 150 mg, 0.45 mmol) and N-ethyldiisopropylamine ( 0.32 mL, 1.85 mmol) in ACN, 2-Bromoethyl ether ( 215 mg, 0.93 mmol) was added to the solution. It was heated to 110 °C sealed tube for 16 hours. The solvent was removed, then purified by RP-HPLC (eluent: water / MeCN *0.1% TFA).
ES/MS: 394.7 (M+H+). 3. EXAMPLE PROCEDURES AND COMPOUND EXAMPLES
Procedure 1: Example 1:
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- 4-((3-methyloxetan-3-yl)amino)nicotinamide
Figure imgf000135_0001
Figure imgf000135_0002
Ethyl 6-chloro-4-((3-methyloxetan-3-yl)amino)nicotinate: A mixture of ethyl 4,6- dichloronicotinate (150 mg, 0.68 mmol), 3-methyloxetan-3-amine hydrochloride (101 mg, 0.818 mmol), and N,N-Diisopropylethylamine (0.3 ml, 1.7 mmol) in
dimethylacetamide (4 mL) was heated at 100 °C for 16 hours. The reaction was cooled to room temperature. Water and EtO Ac were added. The aqueous layer was extracted with EtO Ac and the combined organic layers were dried over sodium sulfate. Filtration and evaporation of solvents yielded the crude product, which was purified by silica gel chromatography (eluent: EtOAc/hexanes).
ES/MS: 271.4 (M+H+).
6-chloro-4-((3-methyloxetan-3-yl)amino)nicotinic acid: ethyl 6-chloro-4-((3- methyloxetan-3-yl)amino)nicotinate (113 mg, 0.42 mmol) was dissolved in 2 mL ethanol. Water (1 mL) was added, followed by lithium hydroxide (30 mg, 1.25 mmol) and the mixture was stirred at room temperature. Upon completion, ethanol was removed under reduced pressure and 2N HCl was added. The product was extracted into ethyl acetate. Upon removed of the solvent under reduced pressure, the crude product was obtained and used without further purification. ES/MS: 243.1 (M+H+).
(R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((3-methyloxetan-3- yl)amino)nicotinamide: A mixture of 6-chloro-4-((3-methyloxetan-3- yl)amino)nicotinic acid (40 mg, 0.17 mmol), (R)-4-amino-3-fluoro-2-methylbutan-2-ol hydrochloride (31 mg, 0.20 mmol), l-[Bis(dimethylamino)methylene]-lH-l,2,3- triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (75.21 mg, 0.20 mmol) and N,N- diisopropylethylamine (0.09 ml, 0.49 mmol) in 0.6 mL DMF was stirred at room temperature for 1 hour. Water was added, and the product was extracted into ethyl acetate. The ethyl acetate solution was concentrated under reduced pressure. The crude product was purified by silica gel chromatography (eluent: EtOAc/hexanes).
ES/MS: 346.2 (M+H+).
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- 4-((3-methyloxetan-3-yl)amino)nicotinamide (Example 1):
A mixture of (R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((3-methyloxetan-3- yl)amino)nicotinamide (15 mg, 0.043 mmol), 7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan- 2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (I-l) (18 mg, 0.067 mmol), XPhos Pd G3 (4 mg), and 2M Potassium phosphate tribasic (0.07 ml) in 1 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 20 minutes. The crude material was purified RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 453.2 (M+H+).
1H NMR (400 MHz, Acetonitrile-d3) δ 9.76 (s, 1H), 8.64 (s, 1H), 8.62 (d, J = 2.2 Hz, 1H), 8.58 (d, J = 2.2 Hz, 1H), 8.00 (d, J = 5.1 Hz, 1H), 7.77 (s, 1H), 7.42 (s, 1H), 7.16 (d, J = 5.1 Hz, 1H), 4.86 (d, J = 6.5 Hz, 2H), 4.72 (d, J = 6.5 Hz, 2H), 1.83 (s, 3H), 1.27 (d, J = 2.0 Hz, 6H).
Alternatively, borylation and suzuki cross coupling can be carried out in tandem:
Figure imgf000137_0001
4,4,4',4',5,5,5',5'-octamethyl- 2,2'-bi(1 ,3,2-dioxaborolane),
Pd(PPh3)2CI2, KOAc,
°C
Figure imgf000137_0002
Example 1
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- 4-((3-methyloxetan-3-yl)amino)nicotinamide (Example 1):
A mixture of 7-bromopyrrolo[l,2-b]pyridazine-3-carbonitrile (I-1F) (32 mg, 0.144 mmol), 4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(l,3,2-dioxaborolane) (59 mg, 0.23 mmol), potassium acetate (43 mg, 0.44 mmol), trans-dichlorobis(triphenylphosphine)palladium (II) (5 mg, 0.01 mmol), dioxane (0.32 ml) and DMF (0.16 ml) was degassed with Argon for 3 minutes. The vial was capped and the mixture was heated under microwave conditions at 120 °C for 20 minutes. The vial was uncapped, and (R)-6-chloro-N-(2- fluoro-3-hydroxy-3-methylbutyl)-4-((3-methyloxetan-3-yl)amino)nicotinamide (28 mg, 0.14 mmol), XPhos Pd G3 (11 mg, 0.013 mmol), 2M Potassium phosphate tribasic (0.13 ml) and 0.8 mL DME were added. The mixture was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 20 minutes. The crude material was purified RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
Procedure 2: Example 2:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lS,3R)-3-hydroxycyclohexyl)amino)nicotinamide
Figure imgf000138_0001
(R)-4,6-dichloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide: 4,6- dichloronicotinic acid (3.0 g, 16 mmol) and the HC1 salt of (R)-4-amino-3-fluor-2- methylbutan-2-ol (2.7 g, 17 mmol) were suspended in DMF (60 mL) at room temperature. To the resulting suspension was added HATU (7.13 g, 18.8 mmol) as a single portion followed by DIPEA (2.7 mL, 16 mmol) as a single portion and the reaction mixture stirred at room temperature for 1 hr. The solvent was removed and the resulting residue partitioned between EtOAc and water. The layers were separated, the water layer extracted twice more with EtOAc. The organic layers were then combined, dried over MgS04, filtered and concentrated with the resulting crude residue then purified via silica gel chromatography (eluent: EtOAc/hexanes) to give the desired product.
ES/MS: 295.2 (M+H+).
6-chloro-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(((lS,3R)-3- hydroxycyclohexyl)amino)nicotinamide: (R)-4,6-dichloro-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide (0.53 g, 1.8 mmol) and (lR,3S)-3-aminocyclohexan-l-ol were added to a microwave vial followed by DMA (5 mL) and DIPEA (0.80 mL, 4.5 mmol). The resulting solution was heated to 160 °C in a microwave reactor for 40 min. The reaction mixture was then poured into water and extracted 3 times with EtOAc. The organic layers were then combined, dried, filtered and concentrated with the resulting crude residue then purified via silica gel chromatography (eluent:
EtOAc/hexanes/MeOH) to give the desired product. Note: In some instances, heating to 160 °C in a microwave reactor for 3 hours is necessary.
ES/MS: 374.3 (M+H+). 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lS,3R)-3-hydroxycyclohexyl)amino)nicotinamide (Example 2): 6-chloro-N-((R)- 2-fluoro-3-hydroxy-3-methylbutyl)-4-(((lS,3R)-3- hydroxycyclohexyl)amino)nicotinamide (0.018 g, 0.048 mmol) and 7-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (0.023 g, 0.087 mmol) were added to a microwave vial followed by DME (0.8 mL), XPhos Pd G3 (4.1 mg, 0.005 mmol) and K3P04 (0.5M in water, 0.19 mL, 0.096 mmol). The resulting mixture was purged with argon for 2 minutes, sealed and heated to 120 °C in a microwave reactor for 10 min. The reaction mixture was filtered and purified by RP- HPLC (eluent: water / MeCN *0.1% TFA). The product fractions were combined and lyophilized to give the final product as a TFA salt.
ES/MS: 481.4 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.67 (d, J = 2.2 Hz, 1H), 8.54 (s, 1H), 8.01 (d, J = 5.0 Hz, 1H), 7.86 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.61 - 4.28 (m, 1H), 4.14 - 3.75 (m, 3H), 3.48 (td, J = 15.6, 15.2, 9.4 Hz, 1H), 2.32 (d, J = 12.5 Hz, 1H), 2.00 (d, J = 37.3 Hz, 3H), 1.70 - 1.34 (m, 4H), 1.29 (d, / = 1.6 Hz, 6H).
Alternatively, the final step can be carried as a tandem borylation of 7-bromopyrrolo[l,2- b]pyridazine-3-carbonitrile (I-1F) following by a terminating Suzuki coupling as described above in Procedure 1.
Procedure 3: Example 3:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((lr,4r)-4-(2-hydroxypropan-2- yl)cyclohexyl)-4-(isopropylamino)nicotinamide
Figure imgf000140_0001
Methyl 6-chloro-4-(isopropylamino)nicotinate: To methyl 4,6-dichloronicotinate (2.0 g, 9.7 mmol) in MeCN (40.0 mL) and water (1.12 mL) was added isopropyl amine (4.17 mL, 48.5 mmol). The reaction mixture was heated to 50 °C for 18 hours, then cooled and concentrated in vacuo. The residue was taken in EtOAc and washed with brine. The organic layer was isolated, dried over sodium sulfate, filtered, concentrated in vacuo, and purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide the desired product.
ES/MS: 229.3 [M+H+].
Methyl 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)nicotinate: A microwave vial was charged with methyl 6-chloro-4-(isopropylamino)nicotinate (300.0 mg, 1.3 mmol), 1-1 (459.0 mmol, 1.7 mmol), XPhos Pd G3 (111.0 mg, 0.13 mmol), and K3PO4 (557.0 mg, 2.6 mmol) and taken under argon. To the vial was added DME (6.0 mL) and water (5.2 mL), and the suspension was degassed with bubbling argon for 60 seconds. The vial was sealed and heated in a microwave reactor at 120 °C for 10 minutes. After cooling, the reaction mixture was concentrated in vacuo, and the resulting residue taken in EtOAc and filtered through a pad of celite. The solution was washed with brine, dried over sodium sulfate, filtered, concentrated in vacuo, and purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide the desired product. ES/MS: 336.2 [M+H+].
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)nicotinic acid: A microwave vial was charged with methyl 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- (isopropylamino)nicotinate (100.0 mg, 0.30 mmol) and lithium iodide (399.1 mg, 3.0 mmol), then pyridine (3.0 mL) was added. The vial was sealed and heated to 150 °C in a microwave reactor for 60 minutes. After cooling, the reaction mixture was concentrated in vacuo. The residue was taken in water and acidified to pH ~4 by slow addition of 2N HCl. The resulting solid was isolated by filtration and washed with water and a minimal amount of EtOAc. The solid was dried under vacuum to provide desired compound, which was used without additional purification.
ES/MS: 322.2 [M+H+].
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((lr,4r)-4-(2-hydroxypropan-2- yl)cyclohexyl)-4-(isopropylamino)nicotinamide (Example 3): A round bottom flask was charged with 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)nicotinic acid (15.0 mg, 0.047 mmol), trans-2-(4-amino-cyclohexyl)-propan-2-ol (7.7 mg, 0.049 mmol), and HATU (18.6 mg, 0.049 mmol). The solids were dissolved in DMF (1.0 mL), then DIPEA (17.5 μί, 0.098 mmol) was added. The reaction mixture was stirred at room temperature for 60 minutes. The reaction was filtered and directly purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 461.4 [M+H+].
1H NMR (400 MHz, Chloroform-d) δ 9.99 (d, J = 7.5 Hz, 1H), 9.03 (s, 1H), 8.45 (d, J = 2.2 Hz, 1H), 8.32 (d, J = 2.1 Hz, 1H), 8.10 (d, J = 5.1 Hz, 1H), 7.93 (s, 1H), 7.69 (d, J = 7.6 Hz, 1H), 7.09 (d, J = 5.0 Hz, 1H), 3.93 (h, J = 6.4 Hz, 1H), 3.89 - 3.77 (m, 1H), 2.08 (d, J = 12.2 Hz, 2H), 1.93 (d, J = 12.5 Hz, 2H), 1.43 (d, J = 6.4 Hz, 6H), 1.40 - 1.21 (m, 3H), 1.19 (s, 6H).
Procedure 4: Example 4:
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3- methylbutyl)-4-(pyridin-3-ylamino)nicotinamide
Figure imgf000142_0001
6-chloro-4-(pyridin-3-ylamino)nicotinic acid: 3-aminopyridine (0.41 g, 4.4 mmol) was dissolved in THF (7 mL) and brought to -78 °C. LiHMDS (1.0M in THF, 6.3 mL, 6.3 mmol) was added dropwise and the resulting solution stirred for 30 min. at -78 °C. 4,6-dichloronicotinic acid (0.40 g, 2.1 mmol) suspended in THF (3 mL) was then added dropwise and the resulting mixture stirred at -78 °C for 5 min. after which the cold bath was removed and the reaction mixture allowed to warm to room temperature and stir for 16 hrs. The reaction was then quenched with 1.0M aqueous HCl and the organic solvents removed by rotary evaporation. The resulting aqueous residue was diluted with water and the pH adjusted to pH 4-5 using 1.0M aqueous HCl and 1.0M aqueous NaOH at which point the solid was filtered, washed with MeOH and dried to give the desired product.
ES/MS: 250.0 [M+H+].
(R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-(pyridin-3- ylamino)nicotinamide: 6-chloro-4-(pyridin-3-ylamino)nicotinic acid (0.050 g, 0.20 mmol) and the HCl salt of (R)-4-amino-3-fluor-2-methylbutan-2-ol (0.063 g, 0.40 mmol) were suspended in DMF (2 mL) at room temperature. To the resulting suspension was added HATU (0.16 g, 0.42 mmol) as a single portion followed by DIPEA (0.09 mL, 0.50 mmol) as a single portion and the reaction mixture stirred at room temperature for 20 min. The reaction mixture was partitioned between EtOAc and water. The layers were separated, the water layer extracted twice more with EtOAc. The organic layers were then combined, dried, filtered and concentrated with the resulting crude residue then purified via silica gel chromatography (eluent: EtOAc/hexanes/MeOH) to give the desired product. ES/MS: 353.1 [M+H+].
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- 4-(pyridin-3-ylamino)nicotinamide (Example 4): (R)-6-chloro-N-(2-fluoro-3-hydroxy- 3-methylbutyl)-4-(pyridin-3-ylamino)nicotinamide (25 mg, 0.071 mmol) and 7-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (34 mg, 0.13 mmol) were added to a microwave vial followed by DME (0.8 mL), XPhos Pd G3 (6.0 mg, 0.007 mmol) and K3P04 (0.5M in water, 0.28 mL, 0.14 mmol). The resulting mixture was purged with argon for 2 minutes, sealed and heated to 120 °C in a microwave reactor for 10 min. The reaction mixture was filtered and purified by RP- HPLC (eluent: water / MeCN *0.1% TFA). The product fractions were combined and lyophilized to give the final product.
ES/MS: 460.2 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.3 Hz, 1H), 8.77 (s, 1H), 8.71 (d, J = 2.2 Hz, 1H), 8.62 (dd, J = 4.9, 1.4 Hz, 1H), 8.57 (d, J = 2.2 Hz, 1H), 8.22 (s, 1H), 8.08 (ddd, J = 8.2, 2.6, 1.4 Hz, 1H), 7.84 (d, J = 5.1 Hz, 1H), 7.73 (ddd, J = 8.2, 4.9, 0.8 Hz, 1H), 7.16 (d, J = 5.0 Hz, 1H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 3.99 (ddd, J = 36.4, 14.5, 2.1 Hz, 1H), 3.62 - 3.45 (m, 1H), 1.30 (d, / = 1.6 Hz, 6H).
Procedure 5: Example 5:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(6-(2-hydroxypropan-2- yl)spiro[3.3]heptan-2-yl)-4-(isopropylamino)nicotinamide
Figure imgf000143_0001
6-chloro-N-(6-(2-hydroxypropan-2-yl)spiro[3.3]heptan-2-yl)-4- (isopropylamino)nicotinamide: Methyl 6-(6-chloro-4-
(isopropylamino)nicotinamido)spiro[3.3]heptane-2-carboxylate (obtained as outlined in steps 1 and 2 of Procedure 2) (50 mg, 0.14 mmol) was dissolved in THF (2 mL) and brought to 0 °C using an ice/water bath. MeMgl (3.0M in ether, 0.14 mL, 0.41 mmol) was then added dropwise and the resulting mixture stirred for 15 min. at 0 °C. More MeMgl (3.0M in ether, 0.27 mL, 0.42 mmol) was then added dropwise at 0 °C, and the resulting mixture stirred for 30 min. at which time it was quenched dropwise using water. The mixture was extracted with EtOAc and the combined organic layers washed with brine, dried over MgS04, filtered, concentrated and purified via silica gel chromatography (eluent: EtOAc/hexanes) to yield the desired product.
ES/MS: 366.3 [M+H+].
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(6-(2-hydroxypropan-2- yl)spiro[3.3]heptan-2-yl)-4-(isopropylamino)nicotinamide (Example 5): 6-chloro-N- (6-(2-hydroxypropan-2-yl)spiro[3.3]heptan-2-yl)-4-(isopropylamino)nicotinamide (0.024 g, 0.066 mmol) and 7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2- b]pyridazine-3-carbonitrile (0.032 mg, 0.12 mmol) were added to a microwave vial followed by DME (0.8 mL), XPhos Pd G3 (5.6 mg, 0.007 mmol) and Na3P04 (0.5M in water, 0.26 mL, 0.13 mmol). The resulting mixture was purged with argon for 2 minutes, sealed and heated to 120 °C in a microwave reactor for 10 min. The reaction mixture was filtered and purified by RP-HPLC (eluent: water / MeCN *0.1% TFA). The product fraction were combined and lyophilized to give the final product.
ES/MS: 473.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1H), 8.65 (d, J = 2.2 Hz, 1H), 8.53 (s, 1H), 7.97 (d, J = 5.0 Hz, 1H), 7.81 (s, 1H), 7.20 (d, J = 5.1 Hz, 1H), 4.44 - 4.28 (m, 1H), 4.13 (hept, J = 6.5 Hz, 1H), 2.62 - 2.48 (m, 1H), 2.37 - 2.20 (m, 2H), 2.18 - 1.93 (m, 5H), 1.90 - 1.78 (m, 1H), 1.39 (d, J = 6.4 Hz, 6H), 1.08 (s, 3H), 1.07 (s, 3H).
Procedure 6: Example 6: 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)-N-(tetrahydro- 2H-pyran-4-yl)nicotinamide
Figure imgf000145_0001
6-bromo-4-(isopropylamino)nicotinic acid: To a solution of methyl 6-bromo-4- (isopropylamino)nicotinate (1.25 g, 4.58 mmol) in a methanol (16 mL) was added aqueous lithium hydroxide (2.5 M, 3.7 mL, 9.25 mmol). The solution was heated to 45 °C for 2.5 hours and cooled to room temperature. Aqueous hydrochloric acid (1M, 9.1 mL) was added and volitiles were removed in vacuo. The resulting slurry was filtered and washed with ¾0 to provide 6-bromo-4-(isopropylamino)nicotinic acid.
ES/MS: 259.419 (M+H+).
6-bromo-4-(isopropylamino)-N-(tetrahydro-2H-pyran-4-yl)nicotinamide: To a solution of 6-bromo-4-(isopropylamino)nicotinic acid (50 mg, 0.19 mmol) in CH2CI2 (2 mL) was added HATU (95 mg, 0.25 mmol), tetrahydropyran-4-amine hydrochloride (32 mg, 0.23 mmol), and DIPEA (0.10 mL, 0.57 mmol). The resulting solution was stirred at room temperature for 1 hour and diluted with CH2CI2. The organic solution was washed with saturated aqueous ammonium chloride (2 times), then dried over Na2S04, and the concentrated to provide 6-bromo-4-(isopropylamino)-N-(tetrahydro-2H-pyran-4- yl)nicotinamide.
ES/MS: 344.139 (M+H+).
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)-N-(tetrahydro-2H- pyran-4-yl)nicotinamide: To a solution of 6-bromo-4-(isopropylamino)-N-(tetrahydro- 2H-pyran-4-yl)nicotinamide (66 mg, 0.19 mmol) in DME (2.5 mL) was added 7-
(4,4,5, 5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (73 mg, 0.27 mmol), XPhos Pd G3 (15 mg, 0.018 mmol), and potassium phosphate tribasic (2M, 0.25 mL, 0.50 mmol). The resulting solution was degassed with argon and heated to 150 °C for 30 minutes. To the reaction mixture was added SiliaMetS® Thiol (50 mg) and the resulting slurry was filtered and wash with DMF. The crude solution was purified by preparative RP-HPLC (eluent: water / MeCN *0.1% TFA) to provide 6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)-N-(tetrahydro-2H-pyran-4- yl)nicotinamide as the TFA salt.
ES/MS: 405.379 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1H), 8.65 (d, J = 2.2 Hz, 1H), 8.55 (s, 1H), 7.98 (d, J = 5.0 Hz, 1H), 7.84 (s, 1H), 7.20 (d, J = 5.1 Hz, 1H), 4.12 (ddt, J = 15.2, 11.0, 5.3 Hz, 2H), 4.05 - 3.94 (m, 2H), 3.53 (td, J = 11.8, 2.1 Hz, 2H), 1.99 - 1.88 (m, 2H), 1.67 (qd, J = 11.9, 4.4 Hz, 2H), 1.39 (d, J = 6.4 Hz, 6H).
Procedure 7: Example 7: 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)-N-(oxetan-3- yl)nicotinamide
Figure imgf000146_0001
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)-N-(oxetan-3- yl)nicotinamide. Starting from bromo-4-(isopropylamino)nicotinic acid (1-4) (30 mg, 0.12 mmol), 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)-N-(oxetan-3- yl)nicotinamide was prepared following the procedures for Example 6, substituting oxetan-3-amine (14 mg, 0.19 mmol) for tetrahydropyran-4-amine hydrochloride. The resulting TFA salt was neutralized with aqueous saturated sodium bicarbonate and extracted with ethyl acetate. The organic layers were dried over Na2S04 and concentrated. The resulting material was purified by silica gel chromatography (eluent: EtOAc/hexanes/MeOH) to provide the product as a free base.
ES/MS: 377.235 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.63 (s, 1H), 8.55 (d, J = 2.2 Hz, 1H), 8.48 (d, J =
2.2 Hz, 1H), 8.13 (s, 1H), 7.80 (d, J = 4.8 Hz, 1H), 7.08 (d, J = 4.9 Hz, 1H), 5.09 (dt, J 7.7, 6.7 Hz, 1H), 4.93 (t, J = 7.0 Hz, 2H), 4.72 (t, J = 6.6 Hz, 2H), 3.87 (p, J = 6.3 Hz, 1H), 1.33 (d, J = 6.3 Hz, 6H). Procedure 8: Example 8:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)-4-((5-oxopyrrolidin-3-yl)amino)nicotinamide
Figure imgf000147_0001
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-((5-oxopyrrolidin-3-yl)amino)nicotinamide (Example 8): 6-chloro-N-((R)-2-fluoro- 3-hydroxy-3-methylbutyl)-4-((5-oxopyrrolidin-3-yl)amino)nicotinamide (obtained as described in Procedure 2 replacing (lR,3S)-3-aminocyclohexan-l-ol with 4- aminopyrrolidin-2-one) (30 mg, 0.084 mmol), (3-cyanopyrrolo[l,2-b]pyridazin-7- yl)boronic acid (19 mg, 0.1 mmol) and Pd-PEPPSI™-IPent catalyst (6.6 mg, 0.008 mmol) were charged in a microwave tube. Dimethoxy ethane (1 mL) and Potassium phosphate tribasic aqueous solution (1 M, 0.25 mL) were added. The reaction mixture was heated to 120 °C in a microwave reactor for 20 minutes and then cooled to room temperature. It was purified by RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the title compound as a TFA salt.
ES/MS: 466.28 [M+H]+.
!H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.69 (d, J = 2.1 Hz, 1H), 8.64 (s, 1H), 8.04 (d, J = 5.1 Hz, 1H), 7.87 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.84 - 4.68 (m, 1H), 4.42 (ddd, J = 49.0, 9.4, 2.1 Hz, 1H), 4.07 - 3.72 (m, 2H), 3.61 - 3.40 (m, 2H), 2.99 (dd, J = 17.1, 8.0 Hz, 1H), 2.48 (dd, J = 17.1, 4.7 Hz, 1H), 1.28 (d, J = 1.7 Hz, 6H).
Procedure 9: Example 9:
7-(5-(((l,l-dioxidotetrahydrothiophen-3-yl)methyl)carbamoyl)-4- (isopropylamino)pyridin-2-yl)pyrrolo[l,2-b]pyridazine-3-carboxamide
Figure imgf000147_0002
7-(5-(((l,l-dioxidotetrahydrothiophen-3-yl)methyl)carbamoyl)-4- (isopropylamino)pyridin-2-yl)pyrrolo[l,2-b]pyridazine-3-carboxamide (Example 9): To a mixture of 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((l,l- dioxidotetrahydrothiophen-3-yl)methyl)-4-(isopropylamino)nicotinamide (Obtained according to the method described in Procedure 1) (5 mg, 0.011 mmol) and potassium carbonate (15 mg, 0.11 mmol) in DMSO (0.5 mL) was added 8 drops of 30 % hydrogen peroxide solution. After stirring at ambient temperature for 10 min, it was purified by RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the title compound as a TFA salt. ES/MS: 471.21 [M+H]+.
H NMR (400 MHz, Methanol-d4) δ 8.91 (d, J = 2.2 Hz, 1H), 8.68 (d, J = 2.3 Hz, 1H), 8.55 (s, 1H), 7.97 (d, J = 5.0 Hz, 1H), 7.80 (s, 1H), 7.11 (d, J = 5.0 Hz, 1H), 4.15 (p, J = 6.4 Hz, 1H), 3.54 (qd, J = 13.7, 6.4 Hz, 2H), 3.26 - 3.02 (m, 2H), 2.97 - 2.73 (m, 2H), 2.50 - 2.29 (m, 1H), 2.08 - 1.81 (m, 1H), 1.40 (d, J = 6.4 Hz, 6H).
Procedure 10: Example 10:
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3- methylbutyl)-4-(methylsulfonamido)nicotinamide
Figure imgf000148_0001
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- 4-(methylsulfonamido)nicotinamide (Example 10): (R)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-
(methylsulfonamido)nicotinamide (Example 10) was prepared as shown in Procedure 1 substituting 6-chloro-4-((3-methyloxetan-3-yl)amino)nicotinic acid with 6-chloro-4- (methylsulfonamido)nicotinic acid (1-6).
Example 10: ES/MS: 461.1 [M+H]+.
1H NMR (400 MHz, Methanol-d4) δ 8.84 (s, 1H), 8.55 (d, J = 11.5 Hz, 2H), 8.34 (s, 1H), 7.78 (s, 1H), 7.11 (d, J = 5.0 Hz, 1H), 4.52 - 4.25 (m, 1H), 4.01 (dd, J = 35.5, 14.9 Hz, 1H), 3.50 (td, J = 14.8, 9.4 Hz, 1H), 2.01 (s, 1H), 1.27 (s, 7H).
Procedure 11: Example 11:
(R)-4-amino-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy- 3-methylbutyl)nicotinamide
Figure imgf000149_0001
(R)-4-amino-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide (Example 11): (R)-4-amino-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide (Example 11) was prepared as shown in Procedure 1 substituting ethyl 6-chloro-4-((3-methyloxetan-3- yl)amino)nicotinate with 4-amino-6-chloronicotinate.
Example 11: ES/MS: 383.2 [M+H]+.
1H NMR (400 MHz, Methanol-d4) δ 8.73 (d, J = 2.2 Hz, 1H), 8.62 (d, J = 2.2 Hz, 1H), 8.56 (s, 1H), 7.87 (s, 1H), 7.83 (d, J = 5.0 Hz, 1H), 7.19 (d, J = 5.0 Hz, 1H), 4.42 (ddd, J = 49.1, 9.3, 2.2 Hz, 1H), 4.10 - 3.80 (m, 1H), 3.60 - 3.38 (m, 1H), 1.28 (d, J = 1.6 Hz, 6H).
Procedure 12: Example 12:
N-((lr,4r)-4-aminocyclohexyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- (isopropylamino)nicotinamide
Figure imgf000149_0002
N-((lr,4r)-4-aminocyclohexyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- (isopropylamino)nicotinamide (Example 12): 7¾ri-butyl ((lr,4r)-4-(6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-
(isopropylamino)nicotinamido)cyclohexyl)carbamate (obtained as described in
Procedure 3 substituting trans-2-(4-amino-cyclohexyl)-propan-2-ol with trans-N-Boc- 1,4-cyclohexanediamine) (57.5 mg, 0.11 mmol) was taken in DCM (1.0 mL), and then trifluoroacetic acid (1.0 mL) was added. The reaction mixture was stirred at room temperature for 30 minutes, then concentrated in vacuo. The residue was taken up in DMF and purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 418.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.66 (d, J = 2.2 Hz, 1H), 8.57 (s, 1H), 8.00 (d, J = 5.0 Hz, 1H), 7.86 (s, 1H), 7.21 (d, J = 5.0 Hz, 1H), 4.15 (hept, J = 6.2 Hz, 1H), 3.89 (d, J = 9.7 Hz, 1H), 3.14 (s, 1H), 2.15 (d, J = 10.2 Hz, 4H), 1.69 - 1.45 (m, 4H), 1.40 (d, J = 6.3 Hz, 6H).
Procedure 13: Example 13 N-((lr,4r)-4-acetamidocyclohexyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)- 4-(isopropylamino)nicotinamide
Figure imgf000150_0001
N-((lr,4r)-4-acetamidocyclohexyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- (isopropylamino)nicotinamide: N-((lr,4r)-4-aminocyclohexyl)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-4-(isopropylamino)nicotinamide (obtained as described in Procedure 12) (15.0 mg, 0.04 mmol) was taken in MeCN (1.0 mL). Triethylamine (0.015 mL, 0.11 mmol) was added followed by the rapid dropwise addition of acetyl chloride (3 μί, 0.04 mmol). The reaction mixture was stirred at room temperature for 15 minutes, then concentrated in vacuo. The residue was taken up in DMF and purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 460.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.66 (d, J = 2.2 Hz, 1H), 8.54 (s, 1H), 7.99 (d, J = 5.0 Hz, 1H), 7.84 (s, 1H), 7.21 (d, J = 5.0 Hz, 1H), 4.15 (hept, J = 6.9, 6.4 Hz, 1H), 3.94 - 3.81 (m, 1H), 3.73 - 3.58 (m, 1H), 2.11 - 1.96 (m, 4H), 1.93 (s, 3H), 1.59 - 1.45 (m, 2H), 1.45 - 1.36 (m, 8H).
Procedure 14: Example 14:
4-(((lR,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide
Figure imgf000151_0001
4-(((lR,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide:
(lR,3r,5S)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate (obtained as described in Procedure 2 substituting (lR,3S)-3-aminocyclohexan-l-ol with N-Boc-endo-3-aminotropane) (70.0 mg, 0.12 mmol) was taken in DCM (1.0 mL), and then trifluoroacetic acid (1.0 mL) was added. The reaction mixture was stirred at room temperature for 30 minutes, then concentrated in vacuo. The residue was taken up in DMF and purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 492.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.70 (d, J = 0.8 Hz, 1H), 8.66 (d, J = 2.2 Hz, 1H), 8.02 (d, J = 5.1 Hz, 1H), 7.78 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.43 (ddd, J = 49.1, 9.3, 2.2 Hz, 1H), 4.36 - 4.26 (m, 1H), 4.16 (s, 2H), 3.93 (ddd, J = 36.2, 14.6, 2.2 Hz, 1H), 3.64 - 3.49 (m, 1H), 2.62 - 2.50 (m, 2H), 2.47 - 2.37 (m, 2H), 2.33 - 2.19 (m, 4H), 1.30 (d, J = 1.7 Hz, 6H).
Procedure 15: Example 15:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)-4-(((lR,3r,5S)-8-(methylsulfonyl)-8-azabicyclo[3.2.1]octan-3- yl)amino)nicotinamide
Figure imgf000151_0002
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lR,3r,5S)-8-(methylsulfonyl)-8-azabicyclo[3.2.1]octan-3- yl)amino)nicotinamide: 4-(((lR,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl)amino)-6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide (obtained as describe in Procedure 14) (7.0 mg, 0.014 mmol) was taken in DCM (0.5 mL). Triethylamine (9.9 μί, 0.071 mmol) was added followed by the rapid dropwise addition of mesyl chloride (1.1 μί, 0.014 mmol). The reaction mixture was stirred at room temperature for 30 minutes, then concentrated in vacuo. The residue was taken up in DMF and purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound. ES/MS: 570.2 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1H), 8.68 (d, J = 2.2 Hz, 1H), 8.63 (s, 1H), 8.00 (d, J = 5.1 Hz, 1H), 7.78 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.51 - 4.31 (m, 3H), 4.24 (t, J = 6.4 Hz, 1H), 3.94 (ddd, J = 36.2, 14.6, 2.2 Hz, 1H), 3.59 - 3.45 (m, 1H), 3.00 (s, 3H), 2.48 (dd, J = 13.0, 7.7 Hz, 2H), 2.31 - 2.11 (m, 4H), 2.05 (d, J = 14.6 Hz, 2H), 1.30 (d, J = 1.7 Hz, 6H).
Procedure 16: Example 16: (R)-4-((l-acetylpiperidin-4-yl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7- yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide
Figure imgf000152_0001
(R)-4-((l-acetylpiperidin-4-yl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide: (R)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-(piperidin-4- ylamino)nicotinamide (obtained as described in Procedure 14 substituting (lR,3r,5S)-3- ((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate with tert-butyl (R)-4-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-((2-fluoro-3-hydroxy- 3-methylbutyl)carbamoyl)pyridin-4-yl)amino)piperidine-l-carboxylate) (10.0 mg, 0.02 mmol) was taken in DCM (1.0 mL). Triethylamine (0.015 mL, 0.11 mmol) was added followed by the rapid dropwise addition of acetyl chloride (1.5 μί, 0.02 mmol). The reaction mixture was stirred at room temperature for 15 minutes, then concentrated in vacuo. The residue was taken up in DMF and purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 508.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.68 (d, J = 2.2 Hz, 1H), 8.60 (s, 1H), 8.05 (d, J = 5.1 Hz, 1H), 7.91 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.52 - 4.31 (m, 2H), 4.22 - 4.11 (m, 1H), 3.93 (dd, J = 34.6, 14.4 Hz, 2H), 3.58 - 3.38 (m, 2H), 3.17 - 3.04 (m, 1H), 2.16 (s, 4H), 1.80 - 1.53 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H). Procedure 17: Example 17
(R)-6-(3-(lH-tetrazol-5-yl)pyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3- methylbutyl)-4-(isopropylamino)nicotinamide
Figure imgf000153_0001
(R)-6-(3-(lH-tetrazol-5-yl)pyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3- methylbutyl)-4-(isopropylamino)nicotinamide (Example 17): To a solution of (R)-6- (3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4- (isopropylamino)nicotinamide (28mg, 0.065 mmol) in 0.13 mL DMF was added ammonium chloride (4 mg, 0.08 mmol) and then sodium azide (5 mg, 0.08 mmol). The mixture was heated at 120 °C fori hour. The reaction was cooled to room temperature. The reaction mixture was diluted with water and methanol and purified by RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt. ES/MS 468.30 (M+H+).
!H NMR (400 MHz, Methanol-^) δ 9.13 (s, 1H), 8.81 - 8.75 (m, 1H), 8.53 (s, 1H), 7.97 (d, J = 5.0 Hz, 1H), 7.76 (s, 1H), 7.10 (d, / = 5.0 Hz, 1H), 4.43 (ddd, / = 49.1, 9.4, 2.1 Hz, 1H), 4.16 (p, / = 6.3 Hz, 1H), 3.93 (ddd, / = 36.3, 14.6, 2.1 Hz, 1H), 3.49 (td, / = 15.3, 9.3 Hz, 1H), 1.41 (d, / = 6.4 Hz, 6H), 1.29 (d, / = 1.6 Hz, 6H).
Procedure 18: Examples 18 (isomer 1) and 19 (isomer 2):
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-(hydroxymethyl)cyclopropyl)-4- (isopropylamino)nicotinamide
Figure imgf000154_0001
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-(hydroxymethyl)cyclopropyl)-4- (isopropylamino)nicotinamide isomer 1 (Example 18) and isomer 2 (Example 19): trans, racemic 6-chloro-N-(2-(hydroxymethyl)cyclopropyl)-4- (isopropylamino)nicotinamide (obtained as described in Procedure 1 substituting trans, racemic (2-aminocyclopropyl)methanol for (R)-4-amino-3-fluoro-2-methylbutan-2-ol) was separated into two distinct enantiomers (trans, isomer 1 and trans, isomer 2). Each isomer was separately elaborated to final compounds (Example 18 and Example 19) as described for the final step of Procedure 1 substituting 6-chloro-N-(2- (hydroxymethyl)cyclopropyl)-4-(isopropylamino)nicotinamide for (R)-6-chloro-N-(2- fluoro-3-hydroxy-3-methylbutyl)-4-((3-methyloxetan-3-yl)amino)nicotinamide.
Example 18: ES/MS: 391.1 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1H), 8.65 (d, J = 2.2 Hz, 1H), 8.49 (s, 1H), 7.98 (d, J = 5.1 Hz, 1H), 7.84 (s, 1H), 7.20 (d, J = 5.0 Hz, 1H), 4.15 (p, J = 6.4 Hz, 1H), 3.54 (d, J = 6.6 Hz, 2H), 2.83 - 2.71 (m, 1H), 1.40 (d, J = 6.4 Hz, 6H), 1.38 - 1.26 (m, 1H), 0.94 - 0.79 (m, 2H). Example 19: ES/MS: 391.2 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1H), 8.65 (d, J = 2.1 Hz, 1H), 8.49 (s, 1H), 7.98 (d, J = 5.0 Hz, 1H), 7.84 (s, 1H), 7.20 (d, J = 5.1 Hz, 1H), 4.15 (p, J = 6.4 Hz, 1H), 3.54 (d, J = 6.6 Hz, 2H), 2.77 (dt, J = 7.6, 4.0 Hz, 1H), 1.40 (d, J = 6.4 Hz, 6H), 1.36 - 1.29 (m, 1H), 0.95 - 0.82 (m, 2H).
Procedure 19: Example 152:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)-N-(6- oxospiro[3.3]heptan-2-yl)nicotinamide
Figure imgf000155_0001
6-chloro-4-(isopropylamino)-N-(6-oxospiro[3.3]heptan-2-yl)nicotinamide: 6-chloro- N-(6-hydroxyspiro[3.3]heptan-2-yl)-4-(isopropylamino)nicotinamide (0.25 g, 0.77 mmol) was dissolved in DCM (5 mL) after which Dess-Martin periodinane (0.39 g, 0.93 mmol) was added as a single portion and the resulting mixture stirred at room temperature. After 30 minutes, the reaction mixture was poured into saturated aqueous NaHC03 solution (20 mL) and extracted twice with EtOAc (2 x 25 mL). The organic layers were dried over MgS04, filtered and concentrated. The resulting material was purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide the desired product.
ES/MS: 322.4 [M+H+].
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)-N-(6- oxospiro[3.3]heptan-2-yl)nicotinamide (Example 152): 6-chloro-4-(isopropylamino)- N-(6-oxospiro[3.3]heptan-2-yl)nicotinamide (0.020 g, 0.062 mmol) and 7-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (0.021 g, 0.081 mmol) were added to a microwave vial followed by DME (0.8 mL), XPhos Pd G3 (5.3 mg, 0.006 mmol) and Na3P04 (0.5M in water, 0.25 mL, 0.12 mmol). The resulting mixture was purged with argon for 2 minutes, sealed and heated to 120 °C in a microwave reactor for 10 min. The reaction mixture was filtered and purified by RP- HPLC (eluent: water / MeCN *0.1% TFA). The product fraction were combined and lyophilized to give the final product.
ES/MS: 429.3 [M+H+]
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.66 (dd, J = 2.2, 0.4 Hz, 1H), 8.57 (s, 1H), 7.99 (dd, J = 5.0, 0.5 Hz, 1H), 7.84 (s, 1H), 7.21 (d, J = 5.2 Hz, 1H), 4.59 - 4.43 (m, 1H), 4.22 - 4.08 (m, 1H), 3.25 - 3.18 (m, 2H), 3.15 - 3.07 (m, 2H), 2.66 (ddd, J = 9.3, 7.7, 2.8 Hz, 2H), 2.47 - 2.36 (m, 2H), 1.40 (d, J = 6.4 Hz, 6H).
Procedure 20: Example 153:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(6-hydroxy-6-methylspiro[3.3]heptan-2- yl)-4-(isopropylamino)nicotinamide
Figure imgf000156_0001
6-chloro-N-(6-hydroxy-6-methylspiro[3.3]heptan-2-yl)-4- (isopropylamino)nicotinamide: 6-chloro-4-(isopropylamino)-N-(6- oxospiro[3.3]heptan-2-yl)nicotinamide (0.10 g, 0.31 mmol) was dissolved in THF (5 mL) and brought to 0 °C using an ice/water bath. MeMgCl (3.0M in THF, 0.36 mL, 1.1 mmol) was then added dropwise at 0 °C. After 30 minutes, the reaction mixture was carefully quenched with water (1 mL) allowed to warm to room temperature and poured into water (10 mL). The resulting mixture was extracted with EtOAc (2 x 25 mL) and the combined organics dried over MgS04, filtered and concentrated. The resulting material was purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide the desired product.
ES/MS: 338.5 [M+H+]
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(6-hydroxy-6-methylspiro[3.3]heptan-2- yl)-4-(isopropylamino)nicotinamide (Example 153): 6-chloro-N-(6-hydroxy-6- methylspiro[3.3]heptan-2-yl)-4-(isopropylamino)nicotinamide (0.020 g, 0.059 mmol) and 7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3- carbonitrile (0.021 g, 0. 77 mmol) were added to a microwave vial followed by DME (0.8 mL), XPhos Pd G3 (5.0 mg, 0.006 mmol) and Na3P04 (0.5M in water, 0.24 mL, 0.12 mmol). The resulting mixture was purged with argon for 2 minutes, sealed and heated to 120 °C in a microwave reactor for 10 min. The reaction mixture was filtered and purified by RP-HPLC (eluent: water / MeCN *0.1% TFA). The product fraction were combined and lyophilized to give the final product.
ES/MS: 445.3 [M+H+]
1H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1H), 8.69 - 8.59 (m, 1H), 8.54 (s, 1H), 8.04 - 7.91 (m, 1H), 7.82 (s, 1H), 7.20 (d, J = 5.1 Hz, 1H), 4.36 (p, J = 8.2 Hz, 1H), 4.13 (p, J = 6.4 Hz, 1H), 2.52 (ddd, J = 11.8, 7.4, 5.0 Hz, 1H), 2.47 - 2.37 (m, 1H), 2.31 - 1.97 (m, 6H), 1.39 (d, J = 6.4 Hz, 6H), 1.31 (s, 3H).
Procedure 21: Example 146:
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- 4-((5-methyl-l,3,4-thiadiazol-2-yl)amino)nicotinamide
Figure imgf000157_0001
(R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((5-methyl-l,3,4-thiadiazol-2- yl)amino)nicotinamide: To a stirring solution of 2-Amino-5-methyl-l,3,4-thiadiazole (0.03 g, 0.27 mmol) in l-methylpyrrolidin-2-one (0.4mL) was added Sodium hydride (60% dispersion in mineral oil, 0.01 g, 0.27 mmol) at room temperature. (R)-4,6- dichloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide (0.05 g, 0.17 mmol) was diluted in l-methylpyrrolidin-2-one (0.4mL) and was added to the deprotonated amine solution. The mixture was stirred at room temperature for several hours. The crude reaction mixture was filtered through a plug of silica gel (eluent: ethyl acetate), concentrated, and further purified by RP-HPLC (eluent: water / MeCN *0.1% TFA). The combined product fractions were basified with sodium bicarbonate solution (aq), and extracted with ethyl acetate (3x). The combined organic layers were dried over sodium sulfate, filtered and concentrated to give the desired product.
ES/MS: 374.1 (M+H+).
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- 4-((5-methyl-l,3,4-thiadiazol-2-yl)amino)nicotinamide (Example 146): (R)-6-chloro- N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((5-methyl-l,3,4-thiadiazol-2- yl)amino)nicotinamide (0.02 g, 0.06 mmol) and 7-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (0.02 g, 0.08 mmol) were added to a microwave vial followed by DME (0.3 mL), XPhos Pd G3 (0.005 g, 0.006 mmol) and K3PO4 (2M in water, 0.058 mL, 0.116 mmol). The resulting mixture was purged with argon for 2 minutes, sealed and heated to 120 °C in a microwave reactor for 15 min. The reaction mixture was filtered and purified by RP-HPLC (eluent: water / MeCN *0.1% TFA). The product fractions were combined and lyophilized to give the final product as a TFA salt.
ES/MS: 481.1 (M+H+).
1H NMR (400 MHz, DMSO-d6) δ 12.06 (s, 1H), 9.42 (d, J = 22.2 Hz, 1H), 9.19 (s, 1H), 8.97 (s, 1H), 8.87 (d, J = 2.3 Hz, 1H), 8.80 (s, 1H), 7.89 (d, J = 4.8 Hz, 1H), 7.13 (d, J = 4.7 Hz, 1H), 2.69 (s, 3H), 1.17 (d, J = 6.3 Hz, 6H), 1.12 (d, J = 1.8 Hz, 3H).
Alternatively, the final step can be carried as a tandem borylation of 7-bromopyrrolo[l,2- b]pyridazine-3-carbonitrile (I- IF) following by a terminating Suzuki coupling as described above in Procedure 1.
Procedure 22: Example 134:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)-N-((lr,4r)-4-(3- methyloxetane-3-carboxamido)cyclohexyl)nicotinamide
Figure imgf000159_0001
Example 134
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)-N-((lr,4r)-4-(3- methyloxetane-3-carboxamido)cyclohexyl)nicotinamide (Example 134): 3- methyloxetane-3-carboxylic acid (7.2 mg, 0.062 mmol) and HATU (24.9 mg, 0.065 mmol) were taken in DMF (0.5 mL). DIPEA (16.7 μΐ,, 0.093 mmol) was added, and the mixture was stirred at room temperature for 5 minutes. After 5 minutes, a solution of N- ((lr,4r)-4-aminocyclohexyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-
(isopropylamino)nicotinamide (obtained as described in Procedure 12) (13.0 mg, 0.031 mmol) in DMF (0.5 mL) and DIPEA (22.2 μί, 0.13 mmol) was added rapidly dropwise. The reaction mixture was stirred at room temperature for 15 minutes then filtered and purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 516.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.66 (d, J = 2.2 Hz, 1H), 8.55 (s, 1H), 7.99 (d, J = 5.1 Hz, 1H), 7.84 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.91 - 4.85 (m, 2H), 4.39 (d, J = 6.1 Hz, 2H), 4.22 - 4.10 (m, 1H), 3.94 - 3.81 (m, 1H), 3.79 - 3.67 (m, 2H), 2.13 - 1.93 (m, 4H), 1.59 (s, 3H), 1.55 - 1.38 (m, 9H).
Procedure 23: Example 122:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((3-hydroxy-l,l- phen-3-yl)methyl)-4-(isopropy
Figure imgf000159_0002
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((3-hydroxy-l,l- dioxidotetrahydrothiophen-3-yl)methyl)-4-(isopropylamino)nicotinamide (Example 122): To a mixture of 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- (isopropylamino)nicotinic acid (10.0 mg, 0.031 mmol) (obtained as described in
Procedure 3), 3-(aminomethyl)-3-hydroxytetrahydrothiophene 1,1-dioxide
hydrochloride (6.0 mg, 0.04 mmol),l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (7.5 mg, 0.039 mmol) and 1-hydroxybenzotriazole (0.4 mg, 0.003 mmol) was added DMF (0.5 mL), then N-Methylmorpholine (8 μί, 0.072 mmol). The reaction mixture was stirred at room temperature for overnight. The reaction was filtered and directly purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 469.13 [M+H+].
!H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1H), 8.66 (d, J = 2.2 Hz, 1H), 8.60 (s, 1H), 7.99 (d, J = 5.1 Hz, 1H), 7.86 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.15 (p, J = 6.4 Hz, 1H), 3.63 (s, 2H), 3.50 - 3.09 (m, 4H), 2.46 - 2.19 (m, 2H), 1.40 (d, J = 6.4 Hz, 6H)
Procedure 24: Example 140: (R)-4-((4-cyanophenyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro- 3-hydroxy-3-methylbutyl)nicotinamide
Figure imgf000160_0001
(R)-6-chloro-4-((4-cyanophenyl)amino)-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide: To a mixture of (R)-4,6-dichloro-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide (150 mg, 0.5 mmol), p-Aminobenzonitrile (90 mg, 0.76 mmol) and Cesium carbonate (331 mg, 1.0 mmol) was added 1.5 mL of DMF. The reaction mixture was stirred at 90 °C for 5 h and cooled to room temperature. The reaction mixture was partitioned between EtOAc and water. The organic layer was separated, washed with brine, dried over Na2S04. Filtered and concentrated. The crude was purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the title compound. ES/MS: 377.16 [M+H+].
(R)-4-((4-cyanophenyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro- 3-hydroxy-3-methylbutyl)nicotinamide (Example 140): (R)-4-((4- cyanophenyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide was synthesized in an identical manner as described in the final step for Procedure 1 substituting (R)-6-chloro-4-((4-cyanophenyl)amino)-N-(2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide for (R)-6-chloro-N-(2-fluoro-3-hydroxy- 3 -methylbutyl) -4- ((3 -methyloxetan- 3 -yl) amino)nicotinamide.
ES/MS: 484.17 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 9.6 Hz, 2H), 8.51 (dd, J = 21.6, 2.2 Hz, 2H), 7.96 - 7.68 (m, 3H), 7.61 - 7.37 (m, 2H), 7.06 (d, J = 4.8 Hz, 1H), 4.45 (ddd, J = 49.0, 9.1, 2.2 Hz, 1H), 3.93 (ddd, J = 35.8, 14.5, 2.3 Hz, 1H), 3.65 - 3.41 (m, 1H), 1.29 (d, J = 1.7 Hz, 6H).
Procedure 25: Example 245:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((3aR,5s,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)amino)nicotinamide:
Figure imgf000161_0001
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((3aR,5s,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)amino)nicotinamide:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4- (((3aR,5s,6aS)-octahydrocyclopenta[c]pyrrol-5-yl)amino)nicotinamide bis(2,2,2- trifluoroacetate) (30.5 mg, 0.042 mmol) was taken in DCE (3.0 mL), and then formaldehyde solution (0.040 ml, 0.402 mmol) and acetic acid (5 drops) were added. The reaction mixture was stirred for 1 hour. Sodium cyanoborohydride (9.18 mg, 0.145 mmol) was added and the reaction was stirred for 2 hours. The reaction mixture was diluted with EtOAc and washed with brine. The aqueous was extracted with EtOAc. The combined organic extracts were dried over sodium sulfate and purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 506.3 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.76 (s, 1H), 8.67 (s, 1H), 8.62 (s, 1H), 8.01 (d, J = 5.1 Hz, 1H), 7.88 (s, 1H), 7.22 (d, J = 5.0 Hz, 1H), 4.41 (ddd, J = 49.3, 9.4, 2.0 Hz, 1H), 4.01 - 3.83 (m, 2H), 3.64 - 3.44 (m, 3H), 3.16 - 3.07 (m, OH), 2.97 (d, J = 10.7 Hz, 6H), 2.25 (s, 2H), 2.02 (t, J = 18.2 Hz, 2H), 1.28 (d, J = 1.6 Hz, 6H). Procedure 26: Example 206:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-((l-((R)-l-(oxetan-3-yl)pyrrolidin-3-yl)-lH-pyrazol-4-yl)amino)nicotinamide:
Figure imgf000162_0001
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-((l-((R)-l-(oxetan-3-yl)pyrrolidin-3-yl)-lH-pyrazol-4-yl)amino)nicotinamide:
To a solution of 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)-4-((l-((R)-pyrrolidin-3-yl)-lH-pyrazol-4-yl)amino)nicotinamide (41.1 mg, 0.06 mmol) and oxetanone (0.02 ml, 0.341 mmol) in DCM (2 mL) and THF (2 mL), was added AcOH (5 drops). After 5 hr, added sodium triacetoxyborohydride (22 mg, 0.104 mmol). The reaction was stirred overnight. The reaction mixture was diluted with DCM and washed with IN NaOH. The organic extract was dried over sodium sulfate and purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1 % TFA) to provide the final compound.
ES/MS: 574.3 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1H), 8.70 (s, 1H), 8.59 (d, J = 2.2 Hz, 1H), 8.14 - 8.05 (m, 2H), 7.85 (d, J = 5.1 Hz, 1H), 7.83 (s, 1H), 7.18 (d, J = 5.1 Hz, 1H), 5.39 (s, 1H), 4.96 (td, J = 7.7, 3.2 Hz, 2H), 4.83 - 4.72 (m, 2H), 4.70 (d, J = 6.0 Hz, 1H), 4.45 (ddd, J = 49.1, 9.3, 2.1 Hz, 1H), 4.10 - 3.70 (m, 3H), 3.66 - 3.42 (m, 1H), 2.73 (dd, J = 14.7, 7.7 Hz, 1H), 2.61 - 2.45 (m, 1H), 1.29 (d, J = 1.6 Hz, 6H). Procedure 27: Example 226:
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((5-(difluoromethyl)pyridin-3- yl)amino)-N-(2-fluor -3-hydroxy-3-methylbutyl)nicotinamide:
Figure imgf000163_0001
(R)-6-chloro-4-((5-(difluoromethyl)pyridin-3-yl)amino)-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide :
R)-4,6-dichloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide (0.050 g, 0.169 mmol) and 5-(difluoromethyl)pyridin-3-amine (0.046 mg, 0.315 mmol) were added to a vial followed by MeCN (1 mL) and Cs2C03 (0.11 g, 0.339 mmol). The resulting solution was heated to 90 °C overnight The reaction mixture was then poured into water and extracted with EtOAc. The organic layer was dried, filtered and concentrated with the resulting crude residue then purified via silica gel chromatography (eluent:
EtOAc/hexanes/MeOH) to give the desired product.
ES/MS: 403.1 (M+).
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((5-(difluoromethyl)pyridin-3- yl)amino)-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide:
(R)-6-chloro-4-((5-(difluoromethyl)pyridin-3-yl)amino)-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide (0.020 g, 0.05 mmol) and 7-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (0.027 g, 0.099 mmol) were added to a microwave vial followed by DME (1.5 mL), XPhos Pd G3 (5.8 mg, 0.007 mmol) and K3PO4 (0.5M in water, 0.25 mL, 0.125 mmol). The resulting mixture was purged with argon for 2 minutes, sealed and heated to 120 °C in a microwave reactor for 10 min. The reaction mixture was filtered and purified by RP-HPLC (eluent: water / MeCN *0.1% TFA). The product fractions were combined and lyophilized to give the final product as a TFA salt.
ES/MS: 510.2 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.91 - 8.84 (m, 1H), 8.78 (s, 2H), 8.71 (d, J = 2.2 Hz, 1H), 8.52 (d, J = 2.2 Hz, 1H), 8.26 (s, 1H), 8.22 (s, 1H), 7.86 (d, J = 5.0 Hz, 1H), 7.17 (d, J = 5.1 Hz, 1H), 7.06 (t, J = 55.2 Hz, 1H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 4.00 (ddd, J = 36.5, 14.6, 2.1 Hz, 1H), 3.54 (ddd, J = 16.2, 14.6, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H). Procedure 28: Example 316:
4-(((lr,4R)-4-aminocyclohexyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7- yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide hydrochloride
Figure imgf000164_0001
Example 316
4-(((lr,4R)-4-aminocyclohexyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N- ((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide hydrochloride: To tert-butyl ((lR,4r)-4-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)cyclohexyl)carbamate (obtained as described in Procedure 2 substituting (lR,3S)-3-aminocyclohexan-l-ol with trans-N-Boc-1,4- cyclohexanediamine) (493.8 mg, 0.85 mmol) was added HCI (4M in 1,4-Dioxane, 3.0 mL). The reaction mixture was stirred at 40 °C for 15 minutes. Upon completion, the reaction was concentrated in vacuo. The residue was triturated with diethylether for 1 hour, and the resulting solid was isolated by vacuum filtration to provide the desired product. Material for subsequent reactions was used without additional purification. Material for biological testing was purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound. ES/MS: 480.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.64 (d, J = 2.2 Hz, 1H), 8.60 (s, 1H), 8.03 (d, J = 5.0 Hz, 1H), 7.87 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.42 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 4.02 - 3.81 (m, 2H), 3.50 (ddd, J = 16.1, 14.5, 9.4 Hz, 1H), 3.23 (tt, J = 11.4, 3.6 Hz, 1H), 2.34 - 2.25 (m, 2H), 2.24 - 2.14 (m, 2H), 1.79 - 1.54 (m, 4H), 1.29 (d, J = 1.7 Hz, 6H). Procedure 29: Example 326:
4-(((lr,4R)-4-acetamidocyclohexyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)- N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide
HCI
Figure imgf000165_0001
Example 326
4-(((lr,4R)-4-acetamidocyclohexyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)- N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide: To a solution of crude 4- (((lr,4R)-4-aminocyclohexyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide hydrochloride (obtained as described in Procedure 28) (30.0 mg, 0.063 mmol) in DMF (1.0 mL) was added triethylamine (52.3 μί, 0.38 mmol) followed by acetyl chloride (35.7 μΐ^. 0.50 mmol). The reaction mixture was stirred at room temperature for 15 minutes, then filtered and directly purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 522.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.99 (t, J = 5.4 Hz, 1H), 8.75 (d, J = 2.2 Hz, 1H), 8.64 (d, J = 2.1 Hz, 1H), 8.57 (s, 1H), 8.02 (d, J = 5.1 Hz, 1H), 7.86 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.42 (ddd, J = 49.0, 9.3, 2.0 Hz, 1H), 4.04 - 3.80 (m, 2H), 3.79 - 3.67 (m, 1H), 3.57 - 3.41 (m, 1H), 2.22 (d, J = 11.2 Hz, 2H), 2.05 (d, J = 11.7 Hz, 2H), 1.95 (s, 3H), 1.65 - 1.45 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
Procedure 30: Example 315:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)-4-(((lr,4R)-4-(methylsulfonamido)cyclohexyl)amino)nicotinamide
Figure imgf000166_0001
Example 31 S
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lr,4R)-4-(methylsulfonamido)cyclohexyl)amino)nicotinamide: 6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4- (((lr,4R)-4-(methylsulfonamido)cyclohexyl)amino)nicotinamide was prepared as described in Procedure 29 substituting acetyl chloride with methansulfonyl chloride. ES/MS: 558.2 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.66 (d, J = 2.2 Hz, 1H), 8.57 (s, 1H), 8.02 (d, J = 5.1 Hz, 1H), 7.87 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.42 (dd, J = 49.0, 7.6 Hz, 1H), 4.02 - 3.79 (m, 2H), 3.58 - 3.41 (m, 2H), 2.99 (s, 3H), 2.30 - 2.09 (m, 4H), 1.68 - 1.48 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
Procedure 31: Example 286:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(((lr,4R)-4-(3,3- dimethylureido)cyclohexyl)amino)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide
Figure imgf000166_0002
Example 286
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(((lr,4R)-4-(3,3- dimethylureido)cyclohexyl)amino)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide: 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(((lr,4R)-4-(3,3- dimethylureido)cyclohexyl)amino)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide was prepared as described in Procedure 29 substituting acetyl chloride with dimethylcarbamoyl chloride. ES/MS: 551.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.65 (d, J = 2.2 Hz, 1H), 8.56 (s, 1H), 7.99 (d, J = 5.1 Hz, 1H), 7.90 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.43 (ddd, J = 49.1, 9.2, 2.1 Hz, 1H), 4.04 - 3.86 (m, 1H), 3.86 - 3.75 (m, 1H), 3.69 - 3.57 (m, 1H), 3.55 - 3.41 (m, 1H), 2.91 (s, 6H), 2.33 - 2.16 (m, 2H), 2.12 - 2.00 (m, 2H), 1.64 - 1.47 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
Procedure 32: Example 285: 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(((lr,4R)-4-((N,N- dimethylsulfamoyl)amino)cyclohexyl)amino)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide
Figure imgf000167_0001
Example 285
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(((lr,4R)-4-((N,N- dimethylsulfamoyl)amino)cyclohexyl)amino)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide: 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(((lr,4R)-4- ((N,N-dimethylsulfamoyl)amino)cyclohexyl)amino)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide was prepared as described in Procedure 29 substituting acetyl chloride with dimethylsulfamoyl chloride.
ES/MS: 587.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1H), 8.65 (d, J = 2.2 Hz, 1H), 8.56 (s, 1H), 8.01 (d, J = 5.1 Hz, 1H), 7.86 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.53 - 4.27 (m, 1H), 4.03 - 3.71 (m, 2H), 3.56 - 3.41 (m, 2H), 2.77 (s, 6H), 2.28 - 2.07 (m, 4H), 1.67 - 1.49 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
Procedure 33: Example 282: 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)-4-(((lr,4R)-4-(3-methyloxetane-3- carboxamido)cyclohexyl)amino)nicotinamide
Figure imgf000168_0001
Example 282
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lr,4R)-4-(3-methyloxetane-3-carboxamido)cyclohexyl)amino)nicotinamide: A flask was charged with 4-(((lr,4R)-4-aminocyclohexyl)amino)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide hydrochloride (prepared as described in Procedure 28) (8.0 mg, 0.017 mmol), 3-methyloxetane-3- carboxylic acid (3.9 mg, 0.033 mmol), and HATU (13.3 mg, 0.035 mmol). The solids were dissolved in DMF (1.0 niL), and then DIPEA (8.9 μί, 0.050 mmol) was added. The reaction mixture was stirred at room temperature for 10 minutes then filtered and directly purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 578.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.65 (d, J = 2.1 Hz, 1H), 8.57 (s, 1H), 8.01 (d, J = 5.1 Hz, 1H), 7.88 (s, 1H), 7.22 (d, J = 5.0 Hz, 1H), 4.87 - 4.86 (m, 2H), 4.52 - 4.33 (m, 3H), 4.03 - 3.73 (m, 3H), 3.55 - 3.40 (m, 1H), 2.30 - 2.17 (m, 2H), 2.12 - 1.99 (m, 2H), 1.69 - 1.48 (m, 7H), 1.30 (d, J = 1.6 Hz, 6H).
Procedure 34: Example 289:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)-4-(((lr,4R)-4-((2,2,2- trifluoroethyl)amino)cyclohexyl)amino)nicotinamide
Figure imgf000169_0001
Example 289
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lr,4R)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)amino)nicotinamide: To a solution of 4-(((lr,4R)-4-aminocyclohexyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7- yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide hydrochloride (prepared as described in Procedure 28) (8.0 mg, 0.017 mmol) in DMF was added triethylamine (9.3 μί, 0.067 mmol) followed by 2,2,2-trifluoroethyl trifluoromethanesulfonate. The reaction mixture was stirred at room temperature for 15 minutes then filtered and directly purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 562.2 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.65 (d, J = 2.2 Hz, 1H), 8.59 (s, 1H), 8.01 (d, J = 5.0 Hz, 1H), 7.88 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.56 - 4.28 (m, 1H), 4.03 - 3.81 (m, 2H), 3.82 - 3.65 (m, 2H), 3.58 - 3.42 (m, 1H), 3.08 - 2.99 (m, 1H), 2.43 - 2.26 (m, 2H), 2.26 - 2.14 (m, 2H), 1.66 - 1.47 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
Procedure 35: Example 293:
(R)-4-(6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(((lr,4R)-4- ((methoxycarbonyl)amino)cyclohexyl)amino)nicotinamido)-3-fluoro-2
methylbutan-2-yl acetate
Figure imgf000169_0002
Example 293 (R)-4-(6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(((lr,4R)-4- ((methoxycarbonyl)amino)cyclohexyl)amino)nicotinamido)-3-fluoro-2- methylbutan-2-yl acetate: To a solution of (R)-4-(4-(((lr,4R)-4-((tert- butoxycarbonyl)amino)cyclohexyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7- yl)nicotinamido)-3-fluoro-2-methylbutan-2-yl acetate (obtained as described in
Procedure 2 substituting (R)-4-amino-3-fluoro-2-methylbutan-2-ol with (R)-4-amino-3- fluoro-2-methylbutan-2-yl acetate) (103.0 mg, 0.17 mmol) in DCM (2.0 mL) was added trifluoroacetic acid (2.0 mL). The reaction mixture was stirred at room temperature for 15 minutes the concentrated in vacuo to dryness. To a solution of the crude residue in DMF (1.5 mL) was added triethylamine (138.6 μί, 0.99 mmol) followed by methyl chloroformate (38.4 μί, 0.50 mmol). The reaction mixture was stirred at room temperature for 15 minutes then filtered and directly purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 580.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.66 (d, J = 2.1 Hz, 1H), 8.58 (s, 1H), 8.01 (d, J = 5.1 Hz, 1H), 7.88 (s, 1H), 7.22 (d, J = 5.0 Hz, 1H), 4.83 (ddd, J = 49.0, 9.3, 1.9 Hz, 1H), 4.02 - 3.79 (m, 2H), 3.64 (s, 3H), 3.59 - 3.42 (m, 2H), 2.27 - 2.16 (m, 2H), 2.13 - 2.03 (m, 2H), 2.03 (s, 3H), 1.66 - 1.44 (m, 10H).
Procedure 36: Example 301:
N-((ls,4S)-4-acetamidocyclohexyl)-4-(((lr,4R)-4-acetamidocyclohexyl)amino)-6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)nicotinamide
Figure imgf000170_0001
Example 301
N-((ls,4S)-4-acetamidocyclohexyl)-4-(((lr,4R)-4-acetamidocyclohexyl)amino)-6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)nicotinamide: To a solution of tert-butyl ((lR,4r)- 4-((5-(((ls,4S)-4-((tert-butoxycarbonyl)amino)cyclohexyl)carbamoyl)-2-(3- cyanopyrrolo[ 1 ,2-b]pyridazin-7-yl)pyridin-4-yl)amino)cyclohexyl)carbamate (obtained as described in Procedure 2 substituting (R)-4-amino-3-fluoro-2-methylbutan-2-ol with trans-N-Boc-l,4-cyclohexanediamine) (75.5 mg, 0.11 rnmol) in DCM (1.0 mL) was added trifluoroacetic acid (1.0 mL). The reaction mixture was stirred at room temperature for 15 minutes the concentrated in vacuo to dryness. To a solution of the crude residue in DMF (1.0 mL) was added triethylamine (61.4 μΐ^, 0.44 mmol) followed by acetyl chloride (15.7 μΐ^, 0.22 mmol). The reaction mixture was stirred at room temperature for 15 minutes then filtered and directly purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 557.2 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.72 (m, 1H), 8.64 (dd, J = 2.2, 0.4 Hz, 1H), 8.54 (s, 1H), 8.00 (d, J = 5.0 Hz, 1H), 7.85 (s, 1H), 7.21 (d, J = 5.1, 0.4 Hz, 1H), 3.94 - 3.78 (m, 2H), 3.79 - 3.60 (m, 2H), 2.25 - 2.19 (m, 2H), 2.09 - 2.03 (m, 3H), 1.99 (d, J = 14.0 Hz, 3H), 1.95 (s, 3H), 1.93 (s, 3H), 1.65 - 1.29 (m, 8H). Procedure 37: Example 302 (isomer 1) and Example 303 (isomer 2):
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- -((2-(hydroxymethyl)cyclopropyl)amino)nicotinamide
Figure imgf000171_0001
trans, trans, isomer 1 trans, isomer 2 racemic mixture Example 302 Example 303
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-((2-(hydroxymethyl)cyclopropyl)amino)nicotinamide isomer 1 (Example 302) and isomer 2 (Example 303): trans, racemic 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N- ((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-((2-
(hydroxymethyl)cyclopropyl)amino)nicotinamide (obtained as described in Procedure 2 substituting (R)-4-amino-3-fluoro-2-methylbutan-2-ol with trans, racemic (2- aminocyclopropyl)methanol) was separated into two distinct enantiomers (trans, isomer 1 and trans, isomer 2) by reverse phase high pressure liquid chromatography (eluent: IPA / MeCN) to provide the final compounds.
Example 302: ES/MS: 453.3 [M+H+]. 1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.68 (d, J = 2.1 Hz, 1H), 8.56 (s, 1H), 8.46 (s, 1H), 8.09 (d, J = 5.0 Hz, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.43 (ddd, J = 49.1, 9.3, 2.2 Hz, 1H), 4.03 (dd, J = 11.4, 4.9 Hz, 1H), 3.93 (ddd, J = 36.4, 14.6, 2.1 Hz, 1H), 3.54 - 3.41 (m, 1H), 3.24 (dd, J = 11.4, 9.2 Hz, 1H), 2.73 (dt, J = 7.3, 3.7 Hz, 1H), 1.45 - 1.34 (m, 1H), 1.29 (d, J = 1.7 Hz, 6H), 1.14 - 0.99 (m, 2H).
Example 303: ES/MS: 453.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.68 (d, J = 2.1 Hz, 1H), 8.56 (s, 1H), 8.46 (s, 1H), 8.09 (d, J = 5.1 Hz, 1H), 7.21 (d, J = 5.0 Hz, 1H), 4.42 (ddd, J = 49.0, 9.3, 2.2 Hz, 1H), 4.03 (dd, J = 11.4, 4.9 Hz, 1H), 3.93 (ddd, J = 36.4, 14.6, 2.2 Hz, 1H), 3.55 - 3.38 (m, 1H), 3.24 (dd, J = 11.4, 9.2 Hz, 1H), 2.76 - 2.68 (m, 1H), 1.47 - 1.34 (m, 1H), 1.29 (d, J = 1.7 Hz, 6H), 1.14 - 0.99 (m, 2H).
Procedure 38: Example 325:
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3- methylbutyl)-4-((l-(3-methyloxetane-3-carbonyl)piperidin-4-yl)amino)nicotinamide
Figure imgf000172_0001
Example 325
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- 4-((l-(3-methyloxetane-3-carbonyl)piperidin-4-yl)amino)nicotinamide: To a solution of crude (R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3- methylbutyl)-4-(piperidin-4-ylamino)nicotinamide (obtained as described in Procedure 14) (16.0 mg, 0.034 mmol), 3-methyloxetane-3-carboxylic acid (8.0 mg, 0.069 mmol), and HATU (27.4 mg, 0.072 mmol) in DMF (2.0 mL) was added DIPEA (43.0 μί, 0.24 mmol). The reaction mixture was stirred at room temperature for 5 minutes then filtered and directly purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound.
ES/MS: 564.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.69 (d, J = 2.2 Hz, 1H), 8.61 (s, 1H), 8.05 (d, J = 5.1 Hz, 1H), 7.91 (s, 1H), 7.23 (d, J = 5.1 Hz, 1H), 4.98 (d, J = 5.9 Hz, 2H), 4.52 - 4.33 (m, 4H), 4.23 - 4.11 (m, 1H), 3.93 (dd, J = 36.2, 14.4 Hz, 1H), 3.58 - 3.42 (m, 1H), 3.30 - 3.18 (m, 2H), 3.19 - 3.07 (m, 1H), 2.23 - 2.12 (m, 2H), 1.78 - 1.61 (m, 5H), 1.29 (d, J = 1.7 Hz, 6H). Procedure 39: Example 269:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)-4-(((lR,4R)-4-((5-methyl-l,3,4-oxadiazol-2- yl)amino)cyclohexyl)amino)nicotinamide
Figure imgf000173_0001
Example 269
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lR,4R)-4-isothiocyanatocyclohexyl)amino)nicotinamide: To a solution of 4- (((lR,4R)-4-aminocyclohexyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)- 2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide hydrochloride (obtained as described in Procedure 28) (20.0 mg, 0.039 mmol) in a biphasic solution of DCM (1.0 mL) and saturated aqueous sodium bicarbonate (1.0 mL) was added thiophosgene (3.3 μί, 0.043 mmol). The reaction mixture was stirred at room temperature for 15 minutes then concentrated in vacuo to provide the crude desired product which was used without additional purification.
ES/MS: 522.3 [M+H+].
4-(((lR,4R)-4-(2-acetylhydrazine-l-carbothioamido)cyclohexyl)amino)-6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide: To a solution of crude 6-(3-cyanopyrrolo[l,2-b]pyridazin-7- yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(((lR,4R)-4- isothiocyanatocyclohexyl)amino)nicotinamide (20.2 mg, 0.039 mmol) in THF (2.0 mL) and DMF (0.1 mL) was added acylhydrazine (4.8 mg, 0.058 mmol). The reaction mixture was stirred at room temperature for 16 hours then concentrated in vacuo to provide the crude desired product which was used without additional purification.
ES/MS: 596.1 [M+H+].
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lR,4R)-4-((5-methyl-l,3,4-oxadiazol-2- yl)amino)cyclohexyl)amino)nicotinamide: To a solution of crude 4-(((lR,4R)-4-(2- acetylhydrazine- 1 -carbothioamido)cyclohexyl)amino)-6-(3-cyanopyrrolo[ 1 ,2- b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide (23.1 mg, 0.039 mmol) in DMF (1.5 mL) was added EDC (24.1 mg, 0.16 mmol) and triethylamine (43.3 μί, 0.31 mmol). The reaction mixture was stirred at room temperature for 60 hours then filtered and directly purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the final compound. ES/MS: 562.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.65 (d, J = 2.2 Hz, 1H), 8.57 (s, 1H), 8.02 (d, J = 5.1 Hz, 1H), 7.87 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.43 (ddd, J = 49.2, 9.5, 2.0 Hz, 1H), 4.04 - 3.81 (m, 2H), 3.59 - 3.41 (m, 2H), 2.37 (s, 3H), 2.31 - 2.15 (m, 4H), 1.72 - 1.53 (m, 4H), 1.30 (d, J = 1.6 Hz, 6H).
Procedure 40: Example 268:
Methyl ((lR,4R)-4-((5-((cyanomethyl)carbamoyl)-2-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)pyridin-4-yl)amino)cyclohexyl)carbamate methyl chloroformate triethylamine, DMF
Figure imgf000175_0001
Example 268
4-(((lR,4R)-4-aminocyclohexyl)amino)-N-(cyanomethyl)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)nicotinamide: tert-butyl ((lR,4R)-4-((5-((cyanomethyl)carbamoyl)-2- (3-cyanopyrrolo[l,2-b]pyridazin-7-yl)pyridin-4-yl)amino)cyclohexyl)carbamate (14 mg, 0.02 mmol) was taken in l,l,l,3,3,3-hexafluoro-2-propanol (0.1 niL). The reaction mixture was heated thermally at 150 °C for 4 hours. The reaction was cooled and
concentrated in vacuo to provide the crude desired product which was used without additional purification.
ES/MS: 415.2 [M+H+]. methyl ((lR,4R)-4-((5-((cyanomethyl)carbamoyl)-2-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)pyridin-4-yl)amino)cyclohexyl)carbamate: methyl ((lR,4R)-4-((5- ((cyanomethyl)carbamoyl)-2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)pyridin-4- yl)amino)cyclohexyl)carbamate was prepared as described in Procedure 29 substituting 4-(((lR,4R)-4-aminocyclohexyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N- ((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide hydrochloride with 4-(((lR,4R)-4- aminocyclohexyl)amino)-N-(cyanomethyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7- yl)nicotinamide and acetyl chloride with methyl chloroformate.
ES/MS: 473.3 [M+H+].
1H NMR (499 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1H), 8.66 (d, J = 2.1 Hz, 1H), 8.58 (s, 1H), 8.02 (d, J = 5.0 Hz, 1H), 7.92 (s, 1H), 7.22 (d, J = 5.0 Hz, 1H), 4.37 (s, 2H), 3.90 - 3.79 (m, 1H), 3.64 (s, 3H), 3.54 - 3.47 (m, 1H), 2.22 (d, J = 12.5 Hz, 2H), 2.08 (d, J = 12.5 Hz, 2H), 1.56 (tt, J = 24.3, 12.1 Hz, 4H). Procedure 41: Example 377:
(R)-4-(benzo[b]thiophen-2-ylamino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide
Figure imgf000176_0001
(R)-4-(benzo[d]thiazol-2-ylamino)-6-chloro-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide: A mixture of (R)-4,6-dichloro-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide (50 mg, 0.17 mmol), 2-aminobenzothiazole (77 mg, 0.51 mmol), and cesium carbonate (195 mg, 0.60 mmol) in dimethylformamide (1.2 mL) was stirred at room temperature for 48 hours. EtOAc was added and the solids were removed via filtration through celite. The filtrate was concentrated and the resulting oil was purified via preparative HPLC (eluent: water / MeCN *0.1% TFA). The desired fractions were concentrated and dissolved in EtOAc. After washing with saturated sodium bicarbonate, the organic layer was dried over MgS04 and concentrated to provide the product.
ES/MS: 409.3 (M+H+).
(R)-4-(benzo[b]thiophen-2-ylamino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide: A mixture of (R)-4-(benzo[d]thiazol- 2-ylamino)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide (29 mg, 0.07 mmol), 7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3- carbonitrile (1-1) (25 mg, 0.09 mmol), XPhos Pd G3 (6 mg), and 2M Potassium phosphate tribasic (0.15 ml) in 1 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 20 minutes. The crude material was purified via RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt. ES/MS: 516.1 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.85 (s, 1H), 8.66 (d, J = 10.4 Hz, 2H), 7.93 (d, J = 5.0 Hz, 1H), 7.85 (d, J = 7.9 Hz, 1H), 7.50 (t, J = 7.7 Hz, 1H), 7.35 (t, J = 7.7 Hz, 1H), 7.17 (d, J = 5.0 Hz, 1H), 4.49 (ddd, J = 49.0, 9.3, 2.2 Hz, 1H), 3.99 (dd, J = 36.0, 14.6 Hz, 1H), 3.58 (dd, J = 15.3, 9.4 Hz, 1H), 1.32 (d, J = 1.6 Hz, 6H).
Procedure 42: Example 373:
(R)-4-((3-carbamoylbicyclo[l.l.l]pentan-l-yl)amino)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide
Figure imgf000177_0001
(R)-6-chloro-4-((3-cyanobicyclo[l.l.l]pentan-l-yl)amino)-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide: (R)-6-chloro-4-((3 -cyanobicyclo [1.1.1 Jpentan- 1 -yl)amino)- N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide was prepared according to the Example 2 using the appropriate starting material(s). (R)-4-((3-carbamoylbicyclo[l.l.l]pentan-l-yl)amino)-6-chloro-N-(2-fluoro-3- hydroxy-3-methylbutyl)nicotinamide: A mixture of (R)-6-chloro-4-((3- cyanobicyclo[l.l.l]pentan-l-yl)amino)-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide (36 mg, 0.10 mmol), potassium carbonate (135 mg, 0.98 mmol), and hydrogen peroxide 30% aqueous solution (0.1 mL, 0.98 mmol) in DMSO (1 mL) was stirred at room temperature for 3 hours. The resulting solution was filtered and purified via preparative HPLC (eluent: water / MeCN *0.1% TFA). The desired fractions were lyophilized to provide the product.
ES/MS: 385.1 (M+H+). (R)-4-((3-carbamoylbicyclo[l.l.l]pentan-l-yl)amino)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide: A mixture of (R)-4-((3-carbamoylbicyclo[ 1.1.1 ]pentan-l -yl)amino)-6-chloro-N-(2-fluoro-3-hydroxy- 3-methylbutyl)nicotinamide (35 mg, 0.07 mmol), 7-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (1-1) (25 mg, 0.09 mmol), XPhos Pd G3 (5 mg), and 2M Potassium phosphate tribasic (0.064 ml) in 1 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 20 minutes. The crude material was purified via RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 492.1 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.84 (d, J = 2.1 Hz, 1H), 8.76 (d, J = 2.2 Hz, 1H), 8.61 (s, 1H), 8.50 (s, 1H), 7.93 (d, J = 5.1 Hz, 1H), 7.23 (d, J = 5.1 Hz, 1H), 4.42 (ddd, J = 49.0, 9.4, 2.0 Hz, 1H), 3.93 (ddd, J = 36.5, 14.6, 2.1 Hz, 1H), 3.47 (td, J = 15.8, 9.4 Hz, 1H), 2.61 (s, 6H), 1.28 (d, J = 1.6 Hz, 6H).
Procedure 43: Example 369:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-isopropyl-4- (isopropylamino)nicotinamide
Figure imgf000178_0001
Example 369
6-Chloro-4-(isopropylamino)nicotinic acid: 6-Chloro-4-(isopropylamino)nicotinic acid was prepared according to Procedure 1 using the appropriate starting material(s). Tert-butyl 6-chloro-4-(isopropylamino)nicotinate: A solution of 6-Chloro-4-
(isopropylamino)nicotinic acid (1.35 g, 6.23 mmol) in toluene (11 mL) was heated to 90 °C. Ν,Ν-diemthylformamide di-tert-butyl acetal (7.63 g, 37.5 mmol) in toluene (11 mL) was added dropwise over 2 hour. The resulting solution was stirred at 90 °C for 12 hours and cooled to room temperature. The reaction mixture was diluted with EtOAc and washed with 5% aqueous lithium chloride (3 times). The aqueous layers were back extracted with EtOAc and the combine organic layers were dried over Na2S04 and concentrated. The crude product was purified by S1O2 chromatography (eluent: EtOAc / hexanes) to provide the desired ester.
ES/MS: 271.4 (M+H+).
Tert-butyl 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)nicotinate: A mixture of tert-butyl 6-chloro-4-(isopropylamino)nicotinate (300 mg, 1.1 mmol), 7- (4,4,5, 5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (I- 1) (374 mg, 1.4 mmol), XPhos Pd G3 (76 mg), and 2M Potassium phosphate tribasic (1.0 ml) in 10 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 20 minutes. The reaction mixture was diluted with EtOAc and washed with water and brine. The aqueous layers were back extracted with EtOAc and the combine organic layers were dried over Na2S04 and concentrated. The crude product was purified by S1O2 chromatography (eluent: EtOAc / hexanes) to provide the desired ester.
ES/MS: 378.0 (M+H+). Tert-butyl 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)nicotinate:
To a solution of tert-butyl 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- (isopropylamino)nicotinate (399 mg, 1.06 mmol) in DCE (6 mL) was added
trifluroacetic acid (0.8 mL, 10.5 mmol) and the resulting solution was heated to 80 °C for 6 hours. The resulting mixture was cooled to room temperature, diluted with water, and concentrated. The resulting solids were filtered, washed with water, and dissolved in a mixture of dichloromethane and methanol. The solution was then dried over MgS04 and concentrated. The resulting crude product was then used without further purification. ES/MS: 322.2 (M+H+). 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-isopropyl-4-
(isopropylamino)nicotinamide: To a solution of tert-butyl 6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-4-(isopropylamino)nicotinate (10 mg, 0.03 mmol) in DMF (1 mL) was added HATU (14.6 mg, 0.04 mmol) and isopropylamine (0.02 mL, 0.23 mmol). The resulting solution was stirred at room temperature for 1 hour and then purified via RP- HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt. ES/MS: 363.3 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1H), 8.65 (dd, J = 2.2, 0.4 Hz, 1H), 8.53 (s, 1H), 7.98 (dd, J = 5.1, 0.5 Hz, 1H), 7.83 (d, J = 0.5 Hz, 1H), 7.20 (d, J = 5.1 Hz, 1H), 4.21 (td, J = 7.4, 6.6, 5.6 Hz, 1H), 4.17 - 4.09 (m, 1H), 1.40 (d, J = 6.4 Hz, 6H), 1.28 (d, J = 6.6 Hz, 6H).
Procedure 44: Example 351:
(lS,3S)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)cyclobutyl methylcarbamate
Figure imgf000180_0001
Methyl 6-chloro-4-(((lS,3S)-3-hydroxycyclobutyl)amino)nicotinate: Methyl 6- chloro-4-(((ls,3s)-3-hydroxycyclobutyl)amino)nicotinate was prepared according to the Procedure 1 using the appropriate starting material(s).
Methyl 6-chloro-4-(((lS,3S)-3-(((4- nitrophenoxy)carbonyl)oxy)cyclobutyl)amino)nicotinate: To a solution of methyl 6- chloro-4-(((lS,3S)-3-hydroxycyclobutyl)amino)nicotinate (151 mg, 0.58 mmol) in DCE (3 mL) and pyridine (0.5 mL) was added 4-nitrophenyl chloroformate (142 mg, 0.70 mmol). The reaction was stirred for 18 hours and then filtered through celite. The filtrate was then concentrated and the resulting material was purified by S1O2 chromatography (eluent: EtOAc / hexanes) to provide the desired carbonate.
ES/MS: 422.2 (M+H+). Methyl 6-chloro-4-(((lS,3S)-3-((methylcarbamoyl)oxy)cyclobutyl)amino)nicotinate:
To a solution of methyl 6-chloro-4-(((lS,3S)-3-(((4- nitrophenoxy)carbonyl)oxy)cyclobutyl)amino)nicotinate (60 mg, 0.14 mmol) in DCE (1 mL) was added methylamine (2M in THF, 0.15 mL, 0.3 mmol). The reaction was stirred at room temperature for 48 hours and diluted with dichloromethane. After washing with aqueous sodium bicarbonate, the organic layer was dried over NS2SO4 and concentrated. The crude material was purified by S1O2 chromatography (eluent: EtOAc / hexanes) to provide the desired carbamate.
ES/MS: 314.2 (M+H+). (lS,3S)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)cyclobutyl methylcarbamate: Starting from methyl 6-chloro-4-(((ls,3s)-3-((methylcarbamoyl)oxy)cyclobutyl)amino)nicotinate, (lS,3s)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)cyclobutyl methylcarbamate was prepared according to the Procedure 1 using the appropriate starting material(s).
ES/MS: 510.3 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.70 (d, J = 2.2 Hz, 1H), 8.57 (s, 1H), 7.99 (d, J = 5.1 Hz, 1H), 7.77 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.43 (ddd, J = 49.1, 9.4, 2.1 Hz, 1H), 4.07 (p, J = 7.8 Hz, 1H), 4.02 - 3.83 (m, 1H), 3.58 - 3.40 (m, 1H), 3.19 - 3.05 (m, 2H), 2.69 (s, 3H), 2.19 (q, J = 9.3 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H). (1H obscured by solvent)
Procedure 45: Example 345:
N-(3-amino-3-methylbutyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamide
Figure imgf000182_0001
Tert-butyl (4-(6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamido)-2-methylbutan-2- yl)carbamate: Tert-butyl (4-(6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamido)-2-methylbutan-2-yl)carbamate was prepared according to the Procedure 1 using the appropriate starting material(s).
N-(3-amino-3-methylbutyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamide: To a solution of tert-butyl (4- (6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2]octan-l- yl)amino)nicotinamido)-2-methylbutan-2-yl)carbamate (205 mg, 0.35 mmol) in DCE (1.4 mL) was added HCl (4M in dioxane, 0.9 mL, 3.6 mmol). The reaction was stirred at room temperature for 3 hour and then concentrated to dryness. The crude material was purified via RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 488.6 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.69 (d, J = 2.1 Hz, 1H), 8.53 (s, 1H), 8.30 (s, 1H), 7.93 (d, J = 5.0 Hz, 1H), 7.21 (d, J = 5.1 Hz, 1H), 3.52 - 3.43 (m, 2H), 2.32 - 2.18 (m, 6H), 2.02 - 1.83 (m, 8H), 1.41 (s, 6H).
Procedure 46: Example 343:
Methyl (4-(6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamido)-2-methylbutan-2- yl)carbamate
Figure imgf000182_0002
Methyl (4-(6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamido)-2-methylbutan-2- yl)carbamate: To a solution of N-(3-amino-3-methylbutyl)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2]octan- l-yl)amino)nicotinamide (25 mg, 0.045 mmol), in DMF (0.5 mL) was added n-ethyldiisopropylamine (0.075 mL, 0.43 mmol) and methyl chloroformate (0.006 mL, 0.078 mmol). The resulting solution was stirred at room temperature for 30 min and purified via RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 546.4 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.69 (d, J = 2.1 Hz, 1H), 8.47 (s, 1H), 8.25 (s, 1H), 7.91 (d, J = 5.1 Hz, 1H), 7.21 (d, J = 5.0 Hz, 1H), 3.56 (s, 3H), 3.42 - 3.35 (m, 2H), 2.25 (t, J = 7.8 Hz, 6H), 2.05 - 1.96 (m, 2H), 1.90 (dd, J = 10.3, 5.7 Hz, 6H), 1.31 (s, 6H). Procedure 47: Example 337:
(R)-4-((4-benzylthiazol-2-yl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide
Figure imgf000183_0001
(R)-4-((4-benzylthiazol-2-yl)amino)-6-chloro-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide: To a solution of (R)-4,6-dichloro-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide (50 mg, 0.17 mmol) in butyronitrile (2 mL) was added 4- benzylthiazol-2-amine (50 mg, 0.26 mmol) and cesium carbonate (110 mg, 0.34 mmol), The resulting slurry was heated to 120 °C for 18 hours. Upon cooling, the reaction was diluted with EtOAc and washed with water and brine. The aqueous layers were back- extracted with EtOAc. The combined organic layers were dried over MgS04 and concentrated to dryness. The crude material was then purified via RP-HPLC (eluent: water / MeCN *0.1% TFA). The resulting product fractions were concentrated, dissolved in MeOH and neutralized through a PL-HC03-MP SPE column. Concentration of the filtrate provided the desired product.
ES/MS: 450.0 (M+H+).
Methyl (4-(6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamido)-2-methylbutan-2- yl)carbamate: A mixture of (R)-4-((4-benzylthiazol-2-yl)amino)-6-chloro-N-(2-fluoro- 3-hydroxy-3-methylbutyl)nicotinamide (29 mg, 0.06 mmol), 7-(4,4,5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (1-1) (23 mg, 0.08 mmol), XPhos Pd G3 (4 mg), and 2M Potassium phosphate tribasic (0.1 ml) in 1 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 20 minutes, diluted with MeOH and concentrated to dryness. The crude product was purified by S1O2 chromatography (eluent: MeOH /CH2CI2). The resulting material was then purified via RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 566.2 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 9.68 (s, 1H), 8.81 (s, 1H), 8.63 (s, 1H), 8.11 (s, 1H), 7.62 (s, 1H), 7.32 (d, J = 3.4 Hz, 4H), 7.26 (d, J = 7.6 Hz, 1H), 7.13 (d, J = 5.0 Hz, 1H), 6.89 (s, 1H), 4.47 (ddd, J = 48.9, 9.2, 2.1 Hz, 1H), 4.11 (s, 2H), 3.98 (ddd, J = 36.1, 14.5, 2.3 Hz, 1H), 3.61 - 3.49 (m, 1H), 1.31 (d, J = 1.7 Hz, 6H).
Procedure 48: Example 338:
(R)-2-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)-N-methylthiazole-4-carboxamide
Figure imgf000185_0001
Methyl (R)-2-((2-chloro-5-((2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl)pyridin- 4-yl)amino)thiazole-4-carboxylate: Methyl (R)-2-((2-chloro-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)thiazole-4-carboxylate was prepared according to the Procedure 48 using the appropriate starting material(s).
(R)-2-((2-chloro-5-((2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl)pyridin-4- yl)amino)-N-methylthiazole-4-carboxamide: To a solution of methyl (R)-2-((2- chloro-5-((2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl)pyridin-4-yl)amino)thiazole-4- carboxylate (44 mg, 0.1 mmol) in MeOH (0.5 mL) was added methylamine (2M in THF, 0.3 mL, 0.6 mmol) and aqueous lithium hydroxide (2.5 M, 0.1 mL, 0.25 mmol). The resulting mixture was stirred at room temperature for 18h and concentrated in vacuo. The crude material was purified via RP-HPLC (eluent: water / MeCN *0.1 % TFA) and the desired fractions were concentrated to dryness. The resulting trifluoroacetate salt was neutralized with aqueous sodium bicarbonate and extracted with EtOAc (3x). The combine organic layers were dried over magnesium sulfate and concentrated to yield the desired amide.
(R)-2-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)-N-methylthiazole-4-carboxamide : A mixture of (R)-2-((2-chloro-5-((2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl)pyridin-4- yl)amino)-N-methylthiazole-4-carboxamide (10 mg, 0.02 mmol), 7-(4,4,5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (1-1) (12 mg, 0.05 mmol), XPhos Pd G3 (3 mg), and 2M Potassium phosphate tribasic (0.05 ml) in 0.5 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 20 minutes, diluted with MeOH, filtered and concentrated to dryness. The resulting material was then purified via RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 523.1 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 9.78 (s, 1H), 8.84 (s, 1H), 8.67 (d, J = 2.2 Hz, 1H), 8.56 (d, J = 2.2 Hz, 1H), 7.94 (d, J = 5.0 Hz, 1H), 7.85 (s, 1H), 7.17 (d, J = 5.0 Hz, 1H), 4.57 - 4.32 (m, 1H), 3.97 (dd, J = 35.4, 13.6 Hz, 1H), 3.61 - 3.39 (m, 1H), 2.94 (s, 3H), 1.31 (d, J = 1.6 Hz, 6H).
Procedure 49: Example 334:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2]octan-l- yl)amino)-N-(2-(methylamino)-2-oxoethyl)nicotinamide
Figure imgf000186_0001
Ethyl 6-chloro-4-((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinate: To a solution of ethyl 4,6-dichloronicotinate (1.86 g, 8.45 mmol) in butryonitrile (24 mL) was added l-aminobicyclo[2.2.2]octan-4-ol hydrochloride (1 g, 5.63 mmol) and cesium carbonate (3.67 g, 11.3 mmol). The resulting slurry was sealed and heated to 120 °C for 24 hours. The resulting mixture was diluted with EtOAc and washed with water and brine. The aqueous layers were back-extracted with EtOAc and the combined organic layers were dried over MgS04 and concentrated to dryness. The crude material was purified by S1O2 chromatography (eluent: MeOH /CH2CI2) to provide the desired product. ES/MS: 325.6 (M+H+).
6-Chloro-4-((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinic acid: To a solution of ethyl 6-chloro-4-((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinate (1.37 g, 4.22 mmol) in EtOH (40 mL) was added lithium hydroxide (2.5 M in H20, 4.25 mL, 10.6 mmol). The resulting solution was heated to 50 °C for 3 hours, cooled to room temperature and neutralized with 2M hydrochloric acid (5.3 mL). The resulting solution was concentrated to dryness and diluted with water at 0 °C. The resulting solids were filtered and washed with water. The resulting product was dried in vacuo and used without further purification.
ES/MS: 297.5 (M+H+).
Methyl (6-chloro-4-((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinoyl)glycinate:
To a solution of 6-chloro-4-((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinic acid (300 mg, 1.0 mmol) in DMF (5 mL) was added glycine methyl ester hydrochloride (190 mg, 1.5 mmol), HATU (577 mg, 1.5 mmol), and DIPEA (0.5 mL, 2.9 mmol). The resulting mixture was stirred at room temperature for 18 hours and diluted with EtOAc.
The resulting solution was washed with 50% aqueous NH4C1 (2 times). The resulting aqueous layers were back-extracted with EtOAc and the combined organic layers were dried over MgS04 and concentrated to dryness. The crude material was purified by S1O2 chromatography (eluent: MeOH /CH2CI2) to provide the desired product.
ES/MS: 368.6 (M+H+).
6-Chloro-4-((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)-N-(2-(methylamino)-2- oxoethyl)nicotinamide: To a solution of methyl (6-chloro-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinoyl)glycinate (343 mg, 0.93 mmol) in MeOH (9 mL) was added 2.5 M aqueous lithium hydroxide (0.95 mL, 2.38 mmol). The resulting solution was stirred at room temperature for 1 hour and neutrailized with 2M hydrochloride acid. The resulting solution was concentrated to dryness and used without further purification.
To a solution of the crude acid (38 mg, 0.1 mmol) in DMF (1.5 mL) was added methylamine (2M in THF, 0.2 mL, 0.4 mmol), HATU (62 mg, 0.16 mmol), and DIPEA (0.05 mL, 0.32 mmol). The resulting solution was stirred at room temperature for 18 hours, diluted with EtOAc, and washed with 50% aqueous NH4CI (2 times) The resulting aqueous layers were back-extracted with EtOAc and the combined organic layers were dried over MgS04 and concentrated to dryness. The crude material was purified by S1O2 chromatography (eluent: MeOH /CH2CI2) to provide the desired product.
ES/MS: 367.1 (M+H+).
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2]octan-l- yl)amino)-N-(2-(methylamino)-2-oxoethyl)nicotinamide: A mixture of 6-chloro-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)-N-(2-(methylamino)-2-oxoethyl)nicotinamide (15 mg, 0.04 mmol), 7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2- b]pyridazine-3-carbonitrile (1-1) (10 mg, 0.04 mmol), XPhos Pd G3 (3 mg), and 2M Potassium phosphate tribasic (0.04 ml) in 0.75 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 20 minutes, diluted with MeOH, filtered and concentrated to dryness. The resulting material was then purified via RP-HPLC (eluent: water / MeCN *0.1 % TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 474.2 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1H), 8.71 (d, J = 2.2 Hz, 1H), 8.60 (s, 1H), 8.31 (s, 1H), 7.93 (d, J = 5.0 Hz, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.00 (s, 2H), 2.78 (s, 3H), 2.30 - 2.17 (m, 6H), 1.90 (dd, J = 10.1, 5.9 Hz, 6H).
Procedure 50: Example 399:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-((4-(2-oxooxazolidin-3-yl)bicyclo[2.2.2]octan-l-yl)amino)nicotinamide
Figure imgf000189_0001
2-Chloroethyl (R)-(4-((2-chloro-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)bicyclo[2.2.2]octan-l-yl)carbamate: To a suspension of (R)-4-((4-aminobicyclo[2.2.2]octan-l-yl)amino)-6-chloro-N-(2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide hydrochloride (150 mg, 0.34 mmol) and DIPEA (1.57 mL, 9 mmol) in MeCN (3 mL) and DMF (1 mL) was added 2-chloroethyl chloroformate ( 98.5 mg, 0.69 mmol). Then reaction was stirred for 1 hour, diluted with EtOAc (30 mL) and washed with sodium bicarbonate solution and brine. The organic layer was concentrated to provide desired product which was used without further purification.
ES/MS: 505.2 (M+H+).
(R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((4-(2-oxooxazolidin-3- yl)bicyclo[2.2.2]octan-l-yl)amino)nicotinamide:
2-Chloroethyl (R)-(4-((2-chloro-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)bicyclo[2.2.2]octan-l-yl)carbamate ( 40 mg, 0.08 mmol) was dissolved in DMF (4 mL), and DBU (60.3 mg, 0.4 mmol) was added to the solution. Then it was heated to 100 C for 3 hours, cooled to room temperature and filtered. The crude material was purified RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 469.2 (M+H+).
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-((4-(2-oxooxazolidin-3-yl)bicyclo[2.2.2]octan-l-yl)amino)nicotinamide
A mixture of (R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((4-(2- oxooxazolidin-3-yl)bicyclo[2.2.2]octan-l-yl)amino)nicotinamide (37 mg, 0.08 mmol), 7- (4,4,5, 5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (I- 1) (43 mg, 0.16 mmol), XPhos Pd G3 (7 mg), and 2M Potassium phosphate tribasic (0.08 ml) in 1 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 20 minutes. The crude material was purified RP- HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt. ES/MS: 453.2 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 8.38 (d, J = 0.9 Hz, 1H), 8.32 - 8.25 (m, 2H), 8.19 (dd, J = 2.3, 0.9 Hz, 1H), 7.73 (dd, J = 4.8, 1.0 Hz, 1H), 6.93 (dd, J = 4.8, 0.9 Hz, 1H), 4.46 - 4.24 (m, 1H), 4.19 (dd, J = 8.9, 6.8 Hz, 2H), 3.85 (ddd, J = 30.8, 14.6, 3.0 Hz, 1H), 3.61 - 3.56 (m, 2H), 3.48 - 3.40 (m, 1H), 2.11 (s, 12H), 1.28 - 1.19 (m, 6H).
Procedure 51: Example 416:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-((4-(methylcarbamoyl)bicyclo[2.2.2]octan-l-yl)amino)nicotinamide
Figure imgf000191_0001
Example 416
(R)-4-((2-chloro-5-((2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl)pyridin-4- yl)amino)bicyclo[2.2.2]octane-l-carboxylic acid:
Methyl (R)-4-((2-chloro-5-((2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl)pyridin-4- yl)amino)bicyclo[2.2.2]octane-l-carboxylate (800 mg, 2 mmol) was dissolved in 2 niL of THF and 1 mL of MeOH. Lithium hydroxide (43.5 mg, 2 mmol) was added and the mixture was stirred at room temperature. Upon completion, solvent was removed under reduced pressure and IN HC1 was added. The product was extracted into ethyl acetate. Upon removal of the solvent under reduced pressure, the crude product was obtained and used without further purification.
ES/MS: 428.4 (M+H+).
(R)-6-Chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((4- (methylcarbamoyl)bicyclo[2.2.2]octan-l-yl)amino)nicotinamide:
A mixture of (R)-4-((2-chloro-5-((2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl)pyridin- 4-yl)amino)bicyclo[2.2.2]octane-l-carboxylic acid (30 mg, 0.07 mmol), methylamine (2M in THF, 11 mg, 0.35 mmol), l-[Bis(dimethylamino)methylene]-lH-l,2,3- triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (53.3 mg, 0.14 mmol) and N,N- diisopropylethylamine (0.09 ml, 0.49 mmol) in 1 mL of DMF was stirred at room temperature for 1 hour. The reaction was diluted with EtOAc and washed with aqueous sodium bicarbonate (2x). The organic layer was dried over sodium sulfate and concentrated to dryness. The crude material was used directly in the next step.
ES/MS: 441.3 (M+H+).
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-((4-(methylcarbamoyl)bicyclo[2.2.2]octan-l-yl)amino)nicotinamide
A mixture of (R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((4- (methylcarbamoyl)bicyclo[2.2.2]octan-l-yl)amino)nicotinamide (31 mg, 0.07 mmol), 7- (4,4,5, 5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (I- 1) (38 mg, 0.14 mmol), XPhos Pd G3 (7 mg), and 2M Potassium phosphate tribasic (0.07 ml) in 1 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 20 minutes. The crude material was purified RP- HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt. ES/MS: 548.4 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.76 (s, 2H), 8.54 (s, 1H), 8.45 (s, 1H), 7.93 (d, J = 5.1 Hz, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.40 (dd, J = 48.7, 9.0 Hz, 1H), 3.91 (dd, J = 36.5, 14.5 Hz, 1H), 3.72 (p, J = 6.6 Hz, 1H), 3.56 - 3.40 (m, 1H), 2.73 (d, J = 3.8 Hz, 3H), 2.18 (t, J = 7.8 Hz, 6H), 2.02 (t, J = 7.4 Hz, 6H), 1.28 (d, J = 1.7 Hz, 6H).
Procedure 52: Example 405: 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-((4-(2-oxoazetidin-l-yl)bicyclo[2.2.2]octan-l-yl)amino)nicotinamide
Figure imgf000193_0001
(R)-3-((4-((2-chloro-5-((2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl)pyridin-4- yl)amino)bicyclo[2.2.2]octan-l-yl)amino)propanoic acid:
To a solution of (R)-4-((4-aminobicyclo[2.2.2]octan-l-yl)amino)-6-chloro-N-(2-fluoro- 3-hydroxy-3-methylbutyl)nicotinamide hydrochloride (300 mg, 0.69 mmol) in MeCN ( 4 mL) was added acrylic acid ( 497 mg, 6.9 mmol) and diisopropylethylamine (891 mg, 6.9 mmol). The reaction was heated to 80 °C for 4 hours. The solvent was removed in vacuo and crude material was dried by high vacuum overnight to provide the desired product which was used without further purification.
ES/MS: 471.2 (M+H+).
(R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((4-(2-oxoazetidin-l- yl)bicyclo[2.2.2]octan-l-yl)amino)nicotinamide:
To a suspension of (R)-3-((4-((2-chloro-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)bicyclo[2.2.2]octan-l-yl)amino)propanoic acid (250 mg, 0.53 mmol) and Sodium bicarbonate ( 1646 mg, 26.5 mmol) in MeCN ( 30 mL) was added methanesulfonyl chloride (608 mg, 5.3 mmol). The mixture was heated to reflux for overnight, cooled to room temperature and concentrated in vacuo. The crude material was purified RP-HPLC (eluent: water / MeCN *0.1 % TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 453.3 (M+H+). 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-((4-(2-oxoazetidin-l-yl)bicyclo[2.2.2]octan-l-yl)amino)nicotinamide:
A mixture of (R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((4-(2-oxoazetidin- l-yl)bicyclo[2.2.2]octan-l-yl)amino)nicotinamide (12 mg, 0.026 mmol), 7-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (1-1) (14.3 mg, 0.053 mmol), XPhos Pd G3 (3 mg), and 2M Potassium phosphate tribasic (0.03 ml) in 1 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 20 minutes. The crude material was purified RP- HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt. ES/MS: 560.4 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.85 - 8.69 (m, 2H), 8.54 (s, 1H), 8.35 (s, 1H), 7.93 (d, J = 5.0 Hz, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.40 (ddd, J = 49.1, 9.4, 2.1 Hz, 1H), 3.91 (ddd, J = 36.5, 14.5, 2.1 Hz, 1H), 3.46 (ddd, J = 15.7, 14.6, 9.4 Hz, 1H), 2.79 (t, J = 4.0 Hz, 2H), 2.19 (dt, J = 24.1, 6.2 Hz, 12H), 1.28 (d, J = 1.7 Hz, 6H). Procedure 53: Example 417 and Example 418:
4-((3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)bicyclo[2.2.2]octan-l-yl acetate and 4- ((5-(((R)-3-acetoxy-2-fluoro-3-methylbutyl)carbamoyl)-2-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)pyridin-4-yl)amino)bicyclo[2.2.2]octan-l-yl acetate
Figure imgf000195_0001
Figure imgf000195_0002
4-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)bicyclo[2.2.2]octan-l-yl acetate and 4- ((5-(((R)-3-acetoxy-2-fluoro-3-methylbutyl)carbamoyl)-2-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)pyridin-4-yl)amino)bicyclo[2.2.2]octan-l-yl acetate:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4- ((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamide (130 mg, 0.26 mmol) in acetic anhydride (3 mL), was heated to 100 °C for 8 hours. The solvent was removed in vacuo and the crude material was purified RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the products as trifluoroacetate salts.
4-((5-(((R)-3-acetoxy-2-fluoro-3-methylbutyl)carbamoyl)-2-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)pyridin-4-yl)amino)bicyclo[2.2.2]octan-l-yl acetate:
Example 417: ES/MS: 591.4 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.72 (d, J = 2.2 Hz, 1H),
8.56 (s, 1H), 8.31 (s, 1H), 7.94 (d, J = 5.1 Hz, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.74 (dd, J =
9.4, 2.0 Hz, 1H), 3.88 (ddd, J = 36.8, 14.6, 2.0 Hz, 1H), 3.50 (ddd, J = 16.3, 14.6, 9.4 Hz,
1H), 2.28 (s, 12H), 2.01 (s, 3H), 1.56 (d, J = 1.7 Hz, 6H).
4-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)bicyclo[2.2.2]octan-l-yl acetate:
Example 418: ES/MS: 548.4 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.72 (d, J = 2.2 Hz, 1H), 8.55 (s, 1H), 8.30 (s, 1H), 7.94 (d, J = 5.0 Hz, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.40 (ddd, J = 49.1, 9.4, 2.1 Hz, 1H), 3.90 (ddd, J = 36.5, 14.5, 2.1 Hz, 1H), 3.55 - 3.38 (m, 1H), 2.28 (s, 12H), 1.97 (s, 3H), 1.28 (d, J = 1.7 Hz, 6H). Procedure 54: Example 414:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- -((4-methoxybicyclo[2.2.2]octan-l-yl)amino)nicotinamide
Figure imgf000196_0001
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-((4-methoxybicyclo[2.2.2]octan-l-yl)amino)nicotinamide:
To a suspension of 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3- hydroxy-3-methylbutyl)-4-((4-hydroxybicyclo[2.2.2]octan^ (25 mg, 0.049 mmol) in acetonitrile ( 1 niL) were added Iodomethane ( 70 mg, 0.5 mmol) and Silver(I) oxide (22.9, 0.1 mmol). The mixture was stirred for overnight, filtered and concentrated. The crude material was purified RP-HPLC (eluent: water / MeCN *0.1 % TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 521.2 (M+H+).
1H NMR (400 MHz, Chloroform-d) δ 8.43 (d, J = 1.5 Hz, 1H), 8.38 - 8.23 (m, 2H), 8.20 (d, J = 2.2 Hz, 1H), 7.90 (dd, J = 4.9, 2.2 Hz, 1H), 6.98 (d, J = 4.9 Hz, 1H), 4.74 - 4.41 (m, 1H), 4.13 - 3.91 (m, 1H), 3.73 - 3.39 (m, 1H), 2.30 - 2.11 (m, 6H), 1.88 (dq, J = 7.5, 4.5, 4.0 Hz, 6H), 1.33 - 1.22 (m, 6H).
Procedure 55: Example 386:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(5-cyanopyridin-2-yl)-4-(((lS,3R)-3- hydroxycyclohexyl)amino)nicotinamide
Figure imgf000197_0002
6-Chloro-N-(5-cyanopyridin-2-yl)-4-(((lS,3R)-3- hydroxycyclohexyl)amino)nicotinamide
To a solution of methyl 6-chloro-4-(((lS,3R)-3-hydroxycyclohexyl)amino)nicotinate ( 78 mg, 0.27 mmol) and 6-aminonicotinonitrile ( 33 mg, 0.27 mmol) in THF (1 mL) was added potassium tert-butoxide ( 33.8 mg, 0.3 mmol). The mixture was stirred for 2 hours, acidified with 1 N HC1 and concentrated in vacuo.. The crude material was purified RP- HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt. ES/MS: 372.2 (M+H+).
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(5-cyanopyridin-2-yl)-4-(((lS,3R)-3- hydroxycyclohexyl)amino)nicotinamide:
A mixture of (R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((4-(2-oxoazetidin- l-yl)bicyclo[2.2.2]octan-l-yl)amino)nicotinamide (13 mg, 0.035 mmol), 7-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (1-1) (18.8 mg, 0.7 mmol), XPhos Pd G3 (5 mg), and 2M Potassium phosphate tribasic (0.035 ml) in 1 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 20 minutes. The crude material was purified RP- HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt. ES/MS: 479.3 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.80 (s, 1H), 8.77 (d, J = 2.2 Hz, 1H), 8.75 (dd, J = 2.3, 0.9 Hz, 1H), 8.68 (d, J = 2.2 Hz, 1H), 8.38 (dd, J = 8.8, 0.9 Hz, 1H), 8.20 (dd, J = 8.8, 2.3 Hz, 1H), 8.06 (d, J = 5.1 Hz, 1H), 8.01 (s, 1H), 7.23 (d, J = 5.1 Hz, 1H), 4.27 (dt, J = 9.6, 5.3 Hz, 1H), 4.14 (s, 1H), 2.18 - 1.84 (m, 2H), 1.83 - 1.68 (m, 4H), 1.46 - 1.23 (m, 2H).
Procedure 56: Example 412:
(R)-4-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)bicyclo[2.2.2]octan-l-yl
Figure imgf000198_0001
(R)-4-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)bicyclo[2.2.2]octan-l-yl
methylcarbamate :
To a solution of (R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3- methylbutyl)-4-((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamide (100 mg, 0.2 mmol), 4-nitrophenyl carbonochloridate (120 mg, 0.6 mmol) and 4- (Dimethylamino)pyridine (73 mg, 0.6 mmol) in DCM (1 mL) and pyridine (2 mL), was stirred at r.t. for overnight. Methylamine was added to the mixture. Removed the solvent and the crude material was purified RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 564.5 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 2H), 8.55 (s, 1H), 8.36 (s, 1H), 7.94 (d, J = 5.1 Hz, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.40 (ddd, J = 49.1, 9.4, 2.1 Hz, 1H), 3.90 (ddd, J = 36.4, 14.6, 2.2 Hz, 1H), 3.47 (ddd, J = 16.0, 14.5, 9.4 Hz, 1H), 2.64 (s, 3H), 2.26 (s, 12H), 1.28 (d, J = 1.7 Hz, 6H).
Procedure 57: Examples 528 and 529:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)-4-(((lS)-3-hydroxy-3-methylcyclohexyl)amino)nicotinamide
Figure imgf000199_0001
6-chloro-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(((S)-3- oxocyclohexyl)amino)nicotinamide: 6-chloro-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)-4-(((lS S)-3-hydroxycyclohexyl)amino)nicotinamide (0.30 g, 0.80 mmol) was dissolved in DCM (6 mL) after which Dess-Martin periodinane (0.41 g, 0.96 mmol) was added as a single portion and the resulting mixture stirred at room temperature. After 30 minutes, the reaction mixture was poured into saturated aqueous NaHC03 solution (20 mL) and extracted twice with EtOAc (2 x 25 mL). The organic layers were dried over MgS04, filtered and concentrated. The resulting material was purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide the desired product. ES/MS: 372.2 [M+H+]. 6-chloro-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(((lS)-3-hydroxy-3- methylcyclohexyl)amino)nicotinamide: 6-chloro-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)-4-(((S)-3-oxocyclohexyl)amino)nicotinamide (0.20 g, 0.54 mmol) was dissolved in THF (5 mL) and brought to 0 °C using an ice/water bath. MeMgCl (3.0M in THF, 0.72 mL, 2.2 mmol) was then added dropwise at 0 °C. After 30 minutes, the reaction mixture was carefully quenched with water (1 mL) allowed to warm to room temperature and poured into water (10 mL). The resulting mixture was extracted with EtOAc (2 x 25 mL) and the combined organics dried over MgS04, filtered and concentrated. The resulting material was purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide the desired products with one diastereomer eluting as a mixture with unreacted starting ketone and the second diastereomer isolated pure.
ES/MS: 388.3 [M+H+] 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lS)-3-hydroxy-3-methylcyclohexyl)amino)nicotinamide (Examples 528 and 529): Each isomer of 6-chloro-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(((lS)-3- hydroxy-3-methylcyclohexyl)amino)nicotinamide was separately elaborated to final compounds (Example 528 and Example 529) as described for the final step of
Procedure 1 substituting 6-chloro-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(((lS)- 3-hydroxy-3-methylcyclohexyl)amino)nicotinamide for (R)-6-chloro-N-(2-fluoro-3- hydroxy-3-methylbutyl)-4-((3-methyloxetan-3-yl)amino)nicotinamide.
Example 528: ES/MS: 495.4 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1H), 8.64 (d, J = 2.2 Hz, 1H), 8.46 (s, 1H), 7.97 (d, J = 5.1 Hz, 1H), 7.80 (s, 1H), 7.20 (d, J = 5.0 Hz, 1H), 4.42 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 4.28 - 4.13 (m, 1H), 4.04 - 3.81 (m, 1H), 3.52 - 3.36 (m, 1H), 2.04 - 1.85 (m, 2H), 1.85 - 1.65 (m, 3H), 1.62 - 1.48 (m, 1H), 1.29 (s, 3H), 1.28 (d, J = 1.7 Hz, 6H).
Example 529 : ES/MS : 495.4 [M+H+] .
1H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1H), 8.65 (d, J = 2.2 Hz, 1H), 8.55 (s, 1H), 8.04 (d, J = 5.0 Hz, 1H), 7.89 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.41 (ddd, J = 49.1, 9.4, 2.1 Hz, 1H), 4.18 - 4.04 (m, 1H), 4.01 - 3.79 (m, 1H), 3.58 - 3.40 (m, 1H), 2.22 - 2.02 (m, 2H), 2.00 - 1.82 (m, 1H), 1.78 - 1.65 (m, 2H), 1.53 - 1.32 (m, 3H), 1.30 - 1.25 (m, 9H).
Procedure 58: Example 524:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3- meth lbut l)-4-(((lS,3R)-3-mor holinoc clohex l)amino)nicotinamide
Figure imgf000200_0001
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-
4-(((lS,3R)-3-morpholinocyclohexyl)amino)nicotinamide: 4-(((lS,3R)-3- aminocyclohexyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3- hydroxy-3-methylbutyl)nicotinamide (27 mg, TFA salt, 0.045 mmol) (obtained as described in Procedure 14 substituting tert-butyl ((lR,3S)-3-((2-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl)pyridin-4- yl)amino)cyclohexyl)carbamate for (lR,3r,5S)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7- yl)-5-(((R)-2-fluoro-3-hydroxy-3-methylbutyl)carbamoyl)pyridin-4-yl)amino)-8- azabicyclo[3.2.1]octane-8-carboxylate) was dissolved in acetonitrile (1 mL) after which potassium carbonate (31 mg, 0.23 mmol) and l-Bromo-2-(2-bromoethoxy)ethane (13 mg, 0.057 mmol) were then added. The reaction vial was sealed and heated to 80 °C for 18 hours. The reaction mixture was partitioned between EtOAc and water. The layers were separated and the water layer extracted twice more with EtOAc. The organic layers were then combined, dried, filtered and concentrated with the resulting crude residue the purified by RP-HPLC (eluent: water / MeCN *0.1% TFA). The product fractions were combined and lyophilized to give the final product.
ES/MS: 550.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1H), 8.67 (d, J = 2.2 Hz, 1H), 8.62 (s, 1H), 8.03 (d, J = 5.0 Hz, 1H), 7.88 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.41 (ddd, J = 49.1, 9.4, 2.0 Hz, 1H), 4.23 - 3.98 (m, 4H), 3.99 - 3.83 (m, 1H), 3.82 - 3.70 (m, 4H), 3.58 - 3.42 (m, 3H), 2.64 - 2.54 (m, 1H), 2.29 - 2.17 (m, 2H), 2.17 - 2.05 (m, 1H), 1.79 - 1.38 (m, 4H), 1.28 (d, J = 1.6 Hz, 6H).
Procedure 59: Examples 515, 516, and 517:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)-4-((3-(methylsulfonyl)cyclohexyl)amino)nicotinamide
Figure imgf000201_0001
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-((3-(methylsulfonyl)cyclohexyl)amino)nicotinamide: 6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-((3- (methylsulfonyl)cyclohexyl)amino)nicotinamide (140 mg, 0.26 mmol) as a mixture of 4 diastereomers (obtained as described in Procedure 2 substituting 6-chloro-N-((R)-2- fluoro-3-hydroxy-3-methylbutyl)-4-((3-(methylsulfonyl)cyclohexyl)amino)nicotinamide for 2-fluoro-3-hydroxy-3-methylbutyl)-4-(((lS,3R)-3- hydroxycyclohexyl)amino)nicotinamide) was purified using chiral SFC to give two diastereomers pure and two diastereomers as a mixture.
Example 515: ES/MS: 543.5 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1H), 8.67 (d, J = 2.2 Hz, 1H), 8.63 (s, 1H), 8.02 (d, J = 5.1 Hz, 1H), 7.93 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.55 - 4.33 (m, 2H), 3.94 (ddd, J = 36.6, 14.5, 2.1 Hz, 1H), 3.62 - 3.43 (m, 1H), 3.41 - 3.31 (m, 1H), 2.98 (s, 3H), 2.36 - 2.21 (m, 2H), 2.21 - 2.10 (m, 1H), 2.09 - 1.98 (m, 1H), 1.98 - 1.84 (m, 3H), 1.83 - 1.69 (m, 1H), 1.29 (d, J = 1.6 Hz, 6H).
Example 516: ES/MS: 543.4 [M+H+].
Example 517: ES/MS: 543.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.69 (d, J = 2.2 Hz, 1H), 8.59 (s, 1H), 7.99 (d, J = 5.1 Hz, 1H), 7.94 (s, 1H), 7.21 (d, J = 5.0 Hz, 1H), 4.57 - 4.30 (m, 1H), 4.06 - 3.83 (m, 2H), 3.62 - 3.41 (m, 1H), 3.37 - 3.31 (m, 1H), 2.96 (s, 3H), 2.70 (d, J = 12.4 Hz, 1H), 2.35 - 2.01 (m, 3H), 1.80 - 1.41 (m, 4H), 1.28 (d, J = 1.7 Hz, 6H).
Procedure 60: Example 510:
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- 4-((6-hydroxy-6-methylspiro[3.3]heptan-2-yl)amino)nicotinamide
Figure imgf000202_0001
(R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((6-oxospiro[3.3]heptan-2- yl)amino)nicotinamide: (R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((6- hydroxyspiro[3.3]heptan-2-yl)amino)nicotinamide (0.20 g, 0.52 mmol) was dissolved in DCM (10 mL) after which Dess-Martin periodinane (0.26 g, 0.62 mmol) was added as a single portion and the resulting mixture stirred at room temperature. After 30 minutes, the reaction mixture was poured into saturated aqueous NaHC03 solution (20 mL) and extracted twice with EtOAc (2 x 25 mL). The organic layers were dried over MgS04, filtered and concentrated. The resulting material was purified by silica gel
chromatography (eluent: EtOAc/hexanes) to provide the desired product. ES/MS: 384.3 [M+H+].
(R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((6-hydroxy-6- methylspiro[3.3]heptan-2-yl)amino)nicotinamide: (R)-6-chloro-N-(2-fluoro-3- hydroxy-3-methylbutyl)-4-((6-oxospiro[3.3]heptan-2-yl)amino)nicotinamide (0.14 g, 0.37 mmol) was dissolved in THF (5 mL) and brought to 0 °C using an ice/water bath. MeMgCl (3.0M in THF, 0.43 mL, 1.3 mmol) was then added dropwise at 0 °C. After 30 minutes, the reaction mixture was carefully quenched with water (1 mL) allowed to warm to room temperature and poured into water (10 mL). The resulting mixture was extracted with EtOAc (2 x 25 mL) and the combined organics dried over MgS04, filtered and concentrated. The resulting material was purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide the desired product.
ES/MS: 400.4 [M+H+]
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- 4-((6-hydroxy-6-methylspiro[3.3]heptan-2-yl)amino)nicotinamide (Example 510):
(R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((6-hydroxy-6- methylspiro[3.3]heptan-2-yl)amino)nicotinamide was elaborated to final compound (Example 510) as described for the final step of Procedure 1 substituting (R)-6-chloro- N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((6-hydroxy-6-methylspiro[3.3]heptan-2- yl)amino)nicotinamide for (R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((3- methyloxetan- 3 -yl) amino)nicotinamide.
ES/MS: 507.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1H), 8.68 (d, J = 2.1 Hz, 1H), 8.56 (s, 1H), 7.99 (d, J = 5.1 Hz, 1H), 7.67 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.53 - 4.33 (m, 1H), 4.32 - 4.22 (m, 1H), 4.03 - 3.82 (m, 1H), 3.59 - 3.37 (m, 1H), 2.82 - 2.62 (m, 2H), 2.39 - 2.23 (m, 2H), 2.24 - 2.05 (m, 4H), 1.32 (s, 3H), 1.29 (d, J = 1.6 Hz, 6H).
Procedure 61: Example 505: N-((lr,4S)-4-acrylamidocyclohexyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- (((lS,3R)-3-hydroxycyclohexyl)amino)nicotinamide
Figure imgf000204_0001
Tert-butyl ((lr,4r)-4-(4,6-dichloronicotinamido)cyclohexyl)carbamate: 4,6- dichloronicotinoyl chloride ( 11.0 g, 52.1 mmol) was dissolved in DCM (150 mL) and added drop wise over 1 hr to a solution of tert-butyl ((lr,4r)-4- aminocyclohexyl)carbamate (11.7 g, 54.7 mmol) in DCM (lOOmL) at 0 °C. After 10 minutes the reaction mixture was added to a separator funnel and washed with 0.1N HC1 (30 mL) then brine (30 mL). The organic layer was dried over MgS04, filtered and concentrated to give crude product. The crude product was triturated with hexanes/DCM (1:1) to give the desired compound which was used without further purification.
N-((lr,4r)-4-acrylamidocyclohexyl)-4,6-dichloronicotinamide: Tert-butyl ((lr,4r)-4- (4,6-dichloronicotinamido)cyclohexyl)carbamate (0.30 g, 0.77 mmol) was dissolved in DCM (2 mL) and TFA (1 mL) and stirred at 25 °C. After 10 minutes the reation mixture was concentrated directly to dryness. The amine intermediate was then taken up in DCM (6 mL) after which trimethylamine (0.32 mL, 2.3 mmol) and DMAP (4.7 mg, 0.038 mmol) were added and the resulting solution brought to 0 °C. 3-chloropropanoyl chloride (0.081 mL, 0.85 mmol) was then added after which the cold bath was removed and the reaction mixture allowed to warm up to 25 °C over 1 hour. The reaction mixture was poured into water (5 mL) and extracted with EtOAc (3 x 5mL). The combined organic layers were dried over MgS04, filtered, concentrated and purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide the desired product.
ES/MS: 342.1 [M+H+].
N-((lr,4S)-4-acrylamidocyclohexyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- (((lS,3R)-3-hydroxycyclohexyl)amino)nicotinamide (Example 505): N-((lr,4r)-4- acrylamidocyclohexyl)-4,6-dichloronicotinamide was elaborated to final compound (Example 505) as described for the final 2 steps of Procedure 2 substituting N-((lr,4r)- 4-acrylamidocyclohexyl)-4,6-dichloronicotinamide for (R)-4,6-dichloro-N-(2-fluoro-3- hydroxy-3-methylbutyl)nicotinamide.
ES/MS: 528.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1H), 8.65 (d, J = 2.2 Hz, 1H), 8.55 (s, 1H), 8.01 (d, J = 5.0 Hz, 1H), 7.90 (s, 1H), 7.21 (d, J = 5.0 Hz, 1H), 6.28 - 6.14 (m, 2H), 5.65 (t, J = 6.0 Hz, 1H), 4.31 - 4.15 (m, 1H), 4.15 - 4.03 (m, 1H), 3.95 - 3.82 (m, 1H), 3.82 - 3.66 (m, 1H), 2.12 - 1.96 (m, 6H), 1.97 - 1.84 (m, 1H), 1.82 - 1.73 (m, 1H), 1.73 - 1.63 (m, 4H), 1.62 - 1.30 (m, 4H).
Procedure 62: Example 501:
(lR,3S)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)cyclohexyl acetate
Figure imgf000205_0001
N-((lr,4S)-4-acrylamidocyclohexyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- (((lS,3R)-3-hydroxycyclohexyl)amino)nicotinamide (Example 501): 6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4- (((lS,3R)-3-hydroxycyclohexyl)amino)nicotinamide (Example 2, 48 mg, 0.10 mmol) was dissolved in THF (1 mL) at 25 °C. To this solution was added DIPEA (0.087 niL, 0.50 mmol) followed by acetic anhydride (0.094 mL, 1.0 mmol). After 15 minutes the reaction mixture was poured into water (3 mL, and extracted with EtOAc (3 x 5mL). The combined organic layers were dried over MgS04, filtered, concentrated and purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide the desired product. ES/MS: 523.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.65 (d, J = 2.2 Hz, 1H), 8.59 (s, 1H), 7.94 (d, J = 5.1 Hz, 1H), 7.79 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 5.20 - 5.05 (m, 1H), 4.42 (ddd, J = 49.1, 9.3, 2.1 Hz, 1H), 4.30 - 4.11 (m, 1H), 3.93 (ddd, J = 36.4, 14.6, 2.1 Hz, 1H), 3.58 - 3.41 (m, 1H), 2.27 - 2.15 (m, 1H), 2.12 - 2.06 (m, 1H), 2.08 (s, 3H), 1.95 - 1.70 (m, 5H), 1.70 - 1.55 (m, 1H), 1.28 (d, J = 1.6 Hz, 6H).
Procedure 63: Example 493:
N-(2-acetamidothiazol-4-yl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- (isopropylamino)nicotinamide
N-(2-aminothiazol-4-yl)-6-chloro-4-(isopropylamino)nicotinamide: A mixture of 6- chloro-4-(isopropylamino)nicotinic acid (0.15 g, 0.70 mmol), 2,4-diamino thiazole hydrochloride (0.21 g, 1.4 mmol), l-[Bis(dimethylamino)methylene]-lH-l,2,3- triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (0.32 g, 0.84 mmol) and N,N- diisopropylethylamine (0.40 ml, 2.3 mmol) in 20 mL DMF was stirred at room temperature for 1 hour. Water was added, and the product was extracted into ethyl acetate. The ethyl acetate solution was concentrated under reduced pressure. The crude product was purified by silica gel chromatography (eluent: EtOAc/hexanes).
ES/MS: 312.1 (M+H+).
N-(2-acetamidothiazol-4-yl)-6-chloro-4-(isopropylamino)nicotinamide: N-(2- aminothiazol-4-yl)-6-chloro-4-(isopropylamino)nicotinamide (50 mg, 0.16 mmol) was dissolved in DMF (1 mL) at 25 °C. To this solution was added DIPEA (0.084 mL, 0.48 mmol) followed by acetyl chloride (0.013 mL, 0.18 mmol). After 30 minutes the reaction mixture was poured into water (3 mL, and extracted with EtOAc (3 x 5mL). The combined organic layers were dried over MgS04, filtered, concentrated and purified by silica gel chromatography (eluent: EtOAc/hexanes) to provide the desired product. ES/MS: 354.3 (M+H+).
N-(2-acetamidothiazol-4-yl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- (isopropylamino)nicotinamide (Example 493): N-(2-acetamidothiazol-4-yl)-6-chloro- 4-(isopropylamino)nicotinamide was elaborated to final compound (Example 493) as described for the final step of Procedure 1 substituting N-(2-acetamidothiazol-4-yl)-6- chloro-4-(isopropylamino)nicotinamide for (R)-6-chloro-N-(2-fluoro-3-hydroxy-3- methylbutyl)-4-((3-methyloxetan-3-yl)amino)nicotinamide.
ES/MS: 461.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.81 (s, 1H), 8.74 (d, J = 2.1 Hz, 1H), 8.67 (d, J = 2.2 Hz, 1H), 8.01 (d, J = 5.1 Hz, 1H), 7.97 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 7.20 (s, 1H), 4.28 - 4.08 (m, 1H), 2.14 (s, 3H), 1.44 (d, J = 6.4 Hz, 6H).
Procedure 64: Example 479:
4-((3-acetamidobicyclo[l.l.l]pentan-l-yl)amino)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-((lr,4r)-4-(methylcarbamoyl)cyclohexyl)nicotinamide
Figure imgf000207_0001
(lr,4r)-4-(4-((3-acetamidobicyclo[l.l.l]pentan-l-yl)amino)-6- chloronicotinamido)cyclohexane-l-carboxylic acid: methyl (lr,4r)-4-(4-((3- acetamidobicyclo [1.1.1 Jpentan- 1 -yl)amino)-6-chloronicotinamido)cyclohexane- 1 - carboxylate (0.097 g, 0.22 mmol) (Obtained as described in steps 1-3 of Procedure 1 substituting N-(3-aminobicyclo[l.l.l]pentan-l-yl)acetamide for 3-methyloxetane-3- amine and methyl (lr,4r)-4-aminocyclohexane-l -carboxylate for (R)-4-amino-3-fluoro- 2-methylbutan-2-ol hydrochloride) was dissolved in Ethanol (2 mL) after which lithium hydroxide (16 mg, 0.69 mmol) was added as a solution in water (0.8 mL). The resulting solution was stirred for 2 hours at which time the ethanol was removed, the remaining aqueous solution adjusted to pH 3-4 using 1.0M HC1 and the desired product collected by filtration.
ES/MS: 421.3 (M+H+).
4-((3-acetamidobicyclo[l.l.l]pentan-l-yl)amino)-6-chloro-N-((lr,4r)-4- (methylcarbamoyl)cyclohexyl)nicotinamide: A mixture of (lr,4r)-4-(4-((3- acetamidobicyclo [1.1.1 Jpentan- 1 -yl)amino)-6-chloronicotinamido)cyclohexane- 1 - carboxylic acid (23 mg, 0.055 mmol), methylamine hydrochloride (4.4 mg, 0.066 mmol), l-[Bis(dimethylamino)methylene]-lH-l,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (25 mg, 0.066 mmol) and N,N-diisopropylethylamine (0.03 ml, 0.16 mmol) in 1 mL DMF was stirred at room temperature for 10 minutes. Water was added, and the product was extracted into ethyl acetate. The ethyl acetate solution was concentrated under reduced pressure. The crude product was purified by silica gel chromatography (eluent: EtOAc/hexanes).
ES/MS: 434.2 (M+H+). 4-((3-acetamidobicyclo[l.l.l]pentan-l-yl)amino)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-((lr,4r)-4-(methylcarbamoyl)cyclohexyl)nicotinamide
(Example 479): 4-((3-acetamidobicyclo[l.l.l]pentan-l-yl)amino)-6-chloro-N-((lr,4r)-4- (methylcarbamoyl)cyclohexyl)nicotinamide was elaborated to final compound (Example 479) as described for the final step of Procedure 1 substituting 4-((3- acetamidobicyclo [1.1.1 Jpentan- 1 -yl)amino)-6-chloro-N-(( lr,4r)-4-
(methylcarbamoyl)cyclohexyl)nicotinamide for (R)-6-chloro-N-(2-fluoro-3-hydroxy-3- methylbutyl)-4-((3-methyloxetan-3-yl)amino)nicotinamide.
ES/MS: 541.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1H), 8.77 (d, J = 2.2 Hz, 1H), 8.60 (s, 1H), 8.56 (s, 1H), 7.95 (d, J = 5.2 Hz, 1H), 7.23 (d, J = 5.1 Hz, 1H), 3.97 - 3.79 (m, 1H), 2.71 (s, 3H), 2.65 (s, 6H), 2.26 - 2.13 (m, 1H), 2.09 (d, J = 12.2 Hz, 2H), 1.97 (s, 3H), 1.92 (d, J = 13.0 Hz, 2H), 1.73 - 1.54 (m, 2H), 1.50 - 1.31 (m, 2H).
Procedure 65: Example 381: (R)-4-((4-((aminooxy)carbonyl)phenyl)amino)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide
Figure imgf000209_0001
(R)-4-((4-carbamoylphenyl)amino)-6-chloro-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide: (R)-6-chloro-4-((4-cyanophenyl)amino)-N-(2-fluoro-3- hydroxy-3-methylbutyl)nicotinamide (80 mg, 0.21 mmol) (synthesized as described in Procedure 24) was dissolved in DMSO (2 mL). Potassium carbonate (0.29 g, 2.1 mmol) and 30% H2O2 (0.22 mL, 2.1 mmol) were then added and the reaction mixture allowed to stir overnight at 25 °C. The reaction mixture was then partitioned between EtOAc and water, the organic layer was dried over MgS04, filtered concentrated and purified by reverse phase high pressure liquid chromatography (eluent: water / MeCN *0.1% TFA) to provide the title compound.
ES/MS: 395.17 [M+H+].
(R)-4-((4-((aminooxy)carbonyl)phenyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7- yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide (Example 381): (R)-4-((4- ((aminooxy)carbonyl)phenyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide was synthesized in an identical manner as described in the final step for Procedure 1 substituting (R)-4-((4- carbamoylphenyl)amino)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide for (R)-6-chloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((3-methyloxetan-3- yl)amino)nicotinamide.
ES/MS: 502.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 1H), 8.69 (d, J = 2.2 Hz, 1H), 8.60 (d, J = 2.2 Hz, 1H), 8.53 (s, 1H), 8.06 (d, J = 8.5 Hz, 2H), 7.84 (d, J = 4.9 Hz, 1H), 7.58 (d, J = 8.5 Hz, 2H), 7.15 (d, J = 5.0 Hz, 1H), 4.47 (dd, J = 49.1, 7.4 Hz, 1H), 3.98 (dd, J = 36.2, 15.1 Hz, 1H), 3.76 - 3.35 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
Procedure 66: Example 535: (R)-4-((4-amino-4-methylcyclohexyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7- yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide
Figure imgf000210_0001
tert-butyl (4-cyano-4-(diallylamino)cyclohexyl)carbamate: To a suspension of N-4- boc-aminocyclohexanone (3.54 g, 16.6 mmol) and diallylamine (2.04 ml, 16.6 mmol) in 0.5M DCE (33 ml) at 0°C was added titanium (iv) ethoxide (3.79 g, 16.6 mmol). The mixture was allowed to stir and warm to room temperature slowly for 21 hours. The reddish brown clear solution was re-cooled to 0 °C and 1M diethylaluminum cyanide solution, 1.0 M in toluene (19.92 ml) was added with vigorous stirring. This mixture was allowed to warm to room temperature and was stirred at this temperature for 5 hours. The reaction mixture was diluted with 40 mL dichloromethane and 40 mL ethyl acetate. Celite (4g) was added, and the mixture was re-cooled to 0°C. Water (10 mL) was added slowly with vigorous stirring. After stirring 5 minutes at room temperature, anhydrous sodium sulfate was added and the mixture was filtered over a pad of celite, then concentrated. The crude product was purified by silica gel chromatography (eluent: EtOAc/hexanes).
H NMR (400 MHz, Chloroform-d) δ 5.87 (dtt, / = 16.7, 10.3, 6.2 Hz, 2H), 5.30 - 5.06 (m, 4H), 4.46 (s, 1H), 3.43 (m, 1H), 3.32 (tt, / = 6.3, 1.4 Hz, 4H), 2.34 - 2.18 (m, 2H), 2.13 - 1.97 (m, 2H), 1.84 (dddd, / = 31.7, 11.2, 8.7, 3.6 Hz, 1H), 1.72 - 1.46 (m, 3H), 1.42 (s, 9H). tert-butyl (4-(diallylamino)-4-methylcyclohexyl)carbamate: tert-butyl (4-cyano-4- (diallylamino)cyclohexyl)carbamate (0.2 g, 0.63 mmol) was dissolved in 0.2 M 2- methyltetrahyrofuran (3.2 ml) and cooled in an ice water bath before methylmagnesium bromide (3.4M in MeTHF, 0.58 ml, 1.97 mmol) was added. The mixture was allowed to warm to room temperature, at which point LC/MS indicates near completion. After continued stirring at room temperature for 14 hours, the mixture was cooled in an ice water bath and quenched with saturated ammonium chloride solution, then extracted with ethyl acetate. The organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated to give the crude product.
ES/MS: 309.1 [M+H+].
(R)-6-chloro-4-((4-(diallylamino)-4-methylcyclohexyl)amino)-N-(2-fluoro-3- hydroxy-3-methylbutyl)nicotinamide: tert-butyl (4-(diallylamino)-4- methylcyclohexyl)carbamate (0.14 g, 0.47 mmol) was treated with hydrogen chloride solution, (4.0 M in 1,4-dioxane, 1.17 ml, 4.68 mmol) in 0.2 M 1,4-dioxane (2.33 ml) at room temperature for 16 hours. The reaction mixture was diluted with diethyl ether and the precipitated product was isolated by vacuum filtration, washed with diethyl ether and dried under vacuum for 1 hour to give
Nl,Nl-diallyl-l-methylcyclohexane-l,4-diamine hydrochloride (119.44 mg, 0.49 mmol). To this was added (R)-4,6-dichloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide (120 mg, 0.41 mmol) and N,N-Diisopropylethylamine (0.29 ml, 1.63 mmol) in DMA (0.4 ml). The mixture was heated under microwave irradiation at 160°C for 30 minutes. The crude reaction mixture was diluted with ethyl acetate, washed with saturated sodium bicarbonate, water, and brine. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by RP-HPLC (eluent: water / MeCN *0.1% TFA). The eluted product solution was basified with saturated sodium bicarbonate and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to give the product as the free base. ES/MS: 467.5 [M+H+].
(R)-4-((4-amino-4-methylcyclohexyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7- yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide
A mixture of (R)-6-chloro-4-((4-(diallylamino)-4-methylcyclohexyl)amino)-N-(2-fluoro- 3-hydroxy-3-methylbutyl)nicotinamide (90 mg), the boronate ester (78 mg), XPhos Pd G3 (17 mg), 2 M Potassium phosphate tribasic (0.2 ml) and 0.15 M DME (1.22 ml) was degassed for 1 minute, then heated under microwave irradiation at 125 °C for 25 minutes. The crude material was purified by RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 494.3 [M+H+]. 1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.67 (d, J = 2.1 Hz, 1H), 8.64 (s, 1H), 8.05 - 7.99 (m, 1H), 7.89 (s, 1H), 7.22 (d, J = 5.0 Hz, 1H), 4.42 (ddd, J = 49.1, 9.5, 2.2 Hz, 1H), 4.07 (s, 1H), 3.91 (ddd, J = 36.5, 14.6, 2.2 Hz, 1H), 3.61 - 3.43 (m, 1H), 2.23 - 1.71 (m, 8H), 1.45 (s, 3H), 1.29 (d, J = 1.7 Hz, 6H).
Procedure 67: Example 542:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lr,3R)-3-((2,2,2-trifluoroacetamido)methyl)cyclobutyl)amino)nicotinamide
Figure imgf000212_0001
4-(((lr,3R)-3-(aminomethyl)cyclobutyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin- 7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide: A solution of tert-butyl (((lR,3r)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)cyclobutyl)methyl)carbamate (475 mg, Example 549) in 6 niL 1,4-dioxane was treated with 3.5 mL of 4 M hydrogen chloride solution in 1,4-dioxane. The mixture was stirred for 7 hours. Diethyl ether was added to fully precipitate the salt, which was collected by vacuum filtration and dried under vacuum. This product was used without further purification for most examples, but further purification is possible by RP-HPLC (eluent: water / MeCN *0.1% TFA) to provide the product as a trifluoroacetate salt.
ES/MS: 466.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.68 (d, J = 2.1 Hz, 1H), 8.62 (s, 1H), 8.03 (d, J = 5.1 Hz, 1H), 7.67 (s, 1H), 7.20 (d, J = 5.1 Hz, 1H), 4.59 - 4.29 (m, 2H), 3.92 (ddd, J = 36.4, 14.7, 2.1 Hz, 1H), 3.51 (ddd, J = 16.0, 14.5, 9.4 Hz, 1H), 3.22 (d, J = 7.9 Hz, 2H), 2.74 (tt, J = 8.8, 4.5 Hz, 1H), 2.55 (ddd, J = 12.7, 7.4, 4.3 Hz, 2H), 2.41 (ddd, J = 13.2, 9.2, 6.4 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H). 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lr,3R)-3-((2,2,2-trifluoroacetamido)methyl)cyclobutyl)amino)nicotinamide: a mixture of 4-(((lr,3R)-3-(aminomethyl)cyclobutyl)amino)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide (13.5 mg), trifluoroacetic anhydride (0.012 mL) and triethylamine (0.015 mL) in DMF (0.15 mL) was stirred at room temperature. Additional trifluoroacetic anhydride was required to complete the reaction. The crude material was purified by RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 562.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.75 (m, 2H), 8.58 (s, 1H), 7.98 (d, J = 5.0 Hz, 1H), 7.81 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.56 - 4.31 (m, 2H), 3.94 (ddd, J = 36.6, 14.5, 2.1 Hz, 1H), 3.61 - 3.40 (m, 3H), 2.65 (dd, J = 8.2, 3.5 Hz, 1H), 2.48 (ddd, J = 11.8, 7.7, 3.8 Hz, 2H), 2.39 - 2.24 (m, 2H), 1.29 (d, J = 1.7 Hz, 6H).
Procedure 68: Example 545:
Methyl (((lR,3r)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3- hydroxy-3-methylbutyl)carbamoyl)pyridin-4- yl)amino)cyclobutyl)methyl)carbamate
Figure imgf000213_0001
Methyl (((lR,3r)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3- hydroxy-3-methylbutyl)carbamoyl)pyridin-4- yl)amino)cyclobutyl)methyl)carbamate: A suspension of 4-(((lr,3R)-3- (aminomethyl)cyclobutyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide (430 mg) in 17 mL dichloromethane was treated with 8.5 mL saturated sodium bicarbonate solution and then with methyl chloroformate (2.65 ml, 5% solution in DCM) at room temperature with vigorous stirring. The reaction is complete within 10 minutes. The mixture was diluted with DCM. The aqueous phase was removed and extracted with DCM. The combined organic layer was dried over anhydrous sodium sulfate, filtered and concentrated. The crude material was purified by RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 524.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.73 (d, J = 2.2 Hz, 1H), 8.57 (s, 1H), 7.99 (d, J = 5.1 Hz, 1H), 7.82 (s, 1H), 7.20 (d, J = 5.1 Hz, 1H), 4.54 - 4.31 (m, 2H), 3.92 (ddd, J = 36.6, 14.5, 2.2 Hz, 1H), 3.68 (s, 3H), 3.49 (ddd, J = 16.1, 14.5, 9.4 Hz, 1H), 3.35 (d, J = 7.5 Hz, 2H), 2.54 (s, 1H), 2.50 - 2.38 (m, 2H), 2.34 - 2.15 (m, 2H), 1.29 (d, J = 1.7 Hz, 6H). Procedure 69: Example 551:
N-(3-acetamido-2,2-difluoropropyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- iso ro lamino nicotinamide
Figure imgf000214_0001
N-(3-amino-2,2-difluoropropyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- (isopropylamino)nicotinamide trifluoroacetate: A solution of tert-butyl (3-(6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)nicotinamido)-2,2- difluoropropyl)carbamate (172 mg) in 3 niL DCM and 1 mL trifluoroacetic acid was stirred at room temperature for 1 hour. The mixture was poured into saturated sodium bicarbonate and extracted with ethyl acetate. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated. Additional product was obtained by freeze drying the aqueous phase and later extracting the solids with methanol. The crude product obtained thusly was used without further purification with an assumed yield of 100%, as the mass is high due to inorganic salt contamination. A fraction of the product was purified by RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 414.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.60 - 8.51 (m, 2H), 8.47 (d, J = 2.2 Hz, 1H), 8.15 (s, 1H), 7.79 (d, J = 4.9 Hz, 1H), 7.07 (d, J = 4.8 Hz, 1H), 3.94 - 3.78 (m, 3H), 2.97 (t, J = 14.0 Hz, 2H), 1.34 (d, J = 6.4 Hz, 6H).
N-(3-acetamido-2,2-difluoropropyl)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4- (isopropylamino)nicotinamide: A mixture of of N-(3-amino-2,2-difluoropropyl)-6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(isopropylamino)nicotinamide (50% purity, 33 mg,), 1.1M Sodium bicarbonate (181.41 μΐ), and 0.1M DCM (399.1 μΐ) was stirred vigorously as acetyl chloride (4.27 μΐ) was added. Additional portions of acetyl chloride drove the reaction to completion. The product was purified by RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 456.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.66 (d, J = 2.2 Hz, 1H), 8.58 (s, 1H), 8.00 (d, J = 5.1 Hz, 1H), 7.84 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.23 - 4.06 (m, 1H), 3.85 (t, J = 13.9 Hz, 2H), 3.78 - 3.62 (m, 2H), 2.02 (s, 3H), 1.40 (d, J = 6.4 Hz, 6H).
Procedure 70: Example 620:
Methyl (((lR,3r)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3- hydroxy-3-methylbutyl)carbamoyl)pyridin-4- yl)amino)cyclobutyl)methyl)(methyl)carbamate
Figure imgf000215_0001
Methyl (((lR,3r)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3- hydroxy-3-methylbutyl)carbamoyl)pyridin-4- yl)amino)cyclobutyl)methyl)(methyl)carbamate (Example 620): To a solution of 6- (3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4- (((lr,3R)-3-((methylamino)methyl)cyclobutyl)amino)nicotinamide (120 mg, 0.25 mmol, prepared as described in Procedure 75 substituting 2.0 M CH3NH2 in THF for
CF3CH2NH2) in DMF (3 mL) at room temperature was added DIPEA (0.22 mL, 1.25 mmol) and methyl chloroformate (47 mg, 0.50 mmol). After 10 minutes the reaction mixture was poured into water (5 mL) and extracted with EtOAc (2 x 15 mL). The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by RP-HPLC (eluent: water / MeCN *0.1 % TFA) to yield the final product as a TFA salt.
ES/MS: 538.3 [M+H]+
1H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1H), 8.68 (d, J = 2.1 Hz, 1H), 8.56 (s, 1H), 7.98 (d, J = 5.1 Hz, 1H), 7.75 (s, 1H), 7.20 (d, J = 5.1 Hz, 1H), 4.43 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 4.25 (p, J = 8.0 Hz, 1H), 3.94 (ddd, J = 36.3, 14.5, 2.1 Hz, 1H), 3.67 (s, 3H), 3.60 - 3.43 (m, 1H), 3.39 (d, J = 7.0 Hz, 2H), 2.93 (s, 3H), 2.80 - 2.68 2H), 2.58 - 2.41 (m, 1H), 2.05 - 1.79 (m, 2H), 1.29 (d, J = 1.6 Hz, 7H).
Procedure 71: Example 622:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2]octan-l- yl)amino)-N-((4-(2-hydroxypropan-2-yl)oxazol-2-yl)methyl)nicotinamide
Figure imgf000216_0001
6-chloro-4-((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)-N-((4-(2-hydroxypropan-2- yl)oxazol-2-yl)methyl)nicotinamide: To a solution of methyl 2-((6-chloro-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamido)methyl)oxazole-4-carboxylate (88 mg, 0.20 mmol, prepared as described in Procedure 1 with the appropriate starting materials) in THF (5 mL) was added methylmagnesium chloride (3.0 M in Et20, 0.34 mL, 1.0 mmol) dropwise at room temperature. After 15 minutes the reaction mixture was quenched by the slow addition of water (5 mL) and extracted with EtOAc (2 x 15 mL). The combined organic layers were dried over MgS04, filtered and concentrated. The resulting crude residue was purified by silica gel chromatography (eluent:
EtOAc/hexanes) to give the desired product.
ES/MS: 435.6 [M+H]+
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2]octan-l- yl)amino)-N-((4-(2-hydroxypropan-2-yl)oxazol-2-yl)methyl)nicotinamide (Example 622): 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2]octan-l- yl)amino)-N-((4-(2-hydroxypropan-2-yl)oxazol-2-yl)methyl)nicotinamide was prepared as described in the final step of Procedure 2 substituting 6-chloro-N((R)-2-fluoro-3- hydroxy-3-methylbutyl)-4-(((lS, 3R)-3-hydroxycyclohexyl)amino)nicotinamide with 6- chloro-4-((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)-N-((4-(2-hydroxypropan-2- yl)oxazol-2-yl)methyl)nicotinamide.
ES/MS: 542.4 [M+H]+
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.70 (d, J = 2.2 Hz, 1H), 8.62 (s, 1H), 8.31 (s, 1H), 7.93 (d, J = 5.1 Hz, 1H), 7.69 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.65 (s, 2H), 2.34 - 2.16 (m, 6H), 2.09 - 1.82 (m, 6H), 1.50 (s, 6H). Procedure 72: Example 638 and Example 640:
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- -((3-(oxazol-5-ylmethyl)cyclobutyl)amino)nicotinamide
Figure imgf000217_0001
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- 4-((3-(oxazol-5-ylmethyl)cyclobutyl)amino)nicotinamide: (R)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((3-(oxazol-5- ylmethyl)cyclobutyl)amino)nicotinamide (20 mg, 0.039 mmol) as a mixture of two isomers was separated using an SFC OJ-H column, co-solvent: 30% MeOH/DEA.
Diastereomer 1 Example 638:
ES/MS: 518.4 [M+H]+
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.66 (d, J = 2.2 Hz, 1H), 8.57 (s, 1H), 8.11 (s, 1H), 7.98 (d, J = 5.1 Hz, 1H), 7.64 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 6.92 (s, 1H), 4.57 - 4.30 (m, 2H), 4.08 - 3.83 (m, 1H), 3.58 - 3.42 (m, 1H), 3.08 - 2.95 (m, 2H), 2.88 - 2.73 (m, 1H), 2.59 - 2.43 (m, 2H), 2.42 - 2.30 (m, 2H), 1.29 (d, J = 1.7 Hz, 6H).
Diastereomer 2 Example 640:
ES/MS: 518.4 [M+H]+
1H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1H), 8.67 (d, J = 2.2 Hz, 1H), 8.55 (s, 1H), 8.09 (s, 1H), 7.97 (d, J = 5.1 Hz, 1H), 7.73 (s, 1H), 7.20 (d, J = 5.0 Hz, 1H), 6.88 (d, J = 1.1 Hz, 1H), 4.56 - 4.33 (m, 1H), 4.33 - 4.19 (m, 1H), 4.08 - 3.79 (m, 1H), 3.65 - 3.41 (m, 1H), 2.91 (d, J = 7.3 Hz, 2H), 2.89 - 2.77 (m, 2H), 2.68 - 2.48 (m, 1H), 1.95 - 1.76 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
Procedure 73: Example 645 and Example 646:
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- 4-((4-(2-methyloxazol-5-yl)cyclohexyl)amino)nicotinamide
Figure imgf000218_0001
(R)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)- 4-((4-(2-methyloxazol-5-yl)cyclohexyl)amino)nicotinamide: (R)-6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)-4-((4-(2- methyloxazol-5-yl)cyclohexyl)amino)nicotinamide (49 mg, 0.090 mmol) as a mixture of two isomers was separated using an SFC OD-H column, co-solvent: 30% EtOH.
Diastereomer 1 Example 645:
ES/MS: 546.5 [M+H]+
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.66 (d, J = 2.2 Hz, 1H), 8.60 (s, 1H), 8.00 (d, J = 5.1 Hz, 1H), 7.86 (s, 1H), 7.21 (d, J = 5.0 Hz, 1H), 6.76 (d, J = 1.2 Hz, 1H), 4.41 (ddd, J = 49.1, 9.4, 2.1 Hz, 1H), 4.24 - 4.15 (m, 1H), 4.05 - 3.82 (m, 1H), 3.59 - 3.42 (m, 1H), 3.02 - 2.90 (m, 1H), 2.42 (s, 3H), 2.17 - 1.90 (m, 6H), 1.90 - 1.74 (m, 2H), 1.28 (d, J = 1.7 Hz, 6H).
Diastereomer 2 Example 646:
ES/MS: 546.4 [M+H]+
1H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1H), 8.66 (d, J = 2.2 Hz, 1H), 8.57 (s, 1H), 8.02 (d, J = 5.1 Hz, 1H), 7.88 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 6.73 (d, J = 1.0 Hz, 1H), 4.56 - 4.29 (m, 1H), 4.04 - 3.82 (m, 2H), 3.60 - 3.42 (m, 1H), 2.90 - 2.73 (m, 1H), 2.41 (s, 3H), 2.32 - 2.13 (m, 4H), 1.83 - 1.52 (m, 4H), 1.29 (d, J = 1.7 Hz, 6H).
Procedure 74: Example 694:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lr,3R)-3-(((5-methyl-l,3,4-oxadiazol-2- yl)amino)methyl)cyclobutyl)amino)nicotinamide
Figure imgf000218_0002
A solution of 4-(((lr R)-3-(aminomethyl)cyclobutyl)amino)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide hydrochloride (33 mg, 0.07 mmol), 5-methyl-l,3,4-oxadiazol-2(3H)-one (6.58 mg, 0.07 mmol) and N,N-Diisopropylethylamine (68.7 μΐ, 0.39 mmol) in DMF (200 μΐ) was treated with (Benzotriazol-l-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (30.53 mg, 0.07 mmol). After stirring at room temperature overnight, the reaction mixture was added to cold water and extracted into ethyl acetate. The organic phase was dried over anhydrous sodium sulfate, filtered, concentrated and purified by RP-HPLC (eluent: water / MeCN *0.1% TFA).
ES/MS: 548.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.66 (d, J = 2.2 Hz, 1H), 8.57 (s, 1H), 7.99 (d, J = 5.0 Hz, 1H), 7.74 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.58 - 4.31 (m, 2H), 3.93 (ddd, J = 36.5, 14.6, 2.1 Hz, 1H), 3.57 - 3.36 (m, 3H), 2.76 - 2.61 (m, 1H), 2.50 (ddd, J = 12.4, 7.4, 3.6 Hz, 2H), 2.38 (s, 3H), 2.37 - 2.23 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
Procedure 75: Example 700:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lr,3R)-3-(((2,2,2-trifluoroethyl)amino)methyl)cyclobutyl)amino)nicotinamide
Figure imgf000219_0001
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lr,3R)-3-formylcyclobutyl)amino)nicotinamide. To a suspension of 6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4- (((lr,3R)-3-(hydroxymethyl)cyclobutyl)amino)nicotinamide, prepared by procedure 2, (120 mg, 0.257 mol) in DCM (1 mL) was added Dess Martin periodinane (130.92 mg, 0.31 mol). Sonication for several minutes resulted in a solution. After 30 minutes stirring at room temperature, the reaction was complete by LCMS. The reaction was diluted with DCM, washed with saturated sodium bicarbonate, and then back extracted with ethyl acetate. The dried and concentrated crude product was chromatographed using 100% ethyl acetate to give the product.
ES/MS: 465.4 (M+H+).
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lr,3R)-3-(((2,2,2-trifluoroethyl)amino)methyl)cyclobutyl)amino)nicotinamide (Example 700). To a solution of 6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2- fluoro-3-hydroxy-3-methylbutyl)-4-(((lr,3R)-3-formylcyclobutyl)amino)nicotinamide (30 mg, 0.06 mmol) and 2,2,2-trifluoroethylamine hydrochloride (7.14 mg, 0.07 mmol) in DCM (0.33 ml) was added AcOH (2 drops). After 1 hr, sodium
triacetoxyborohydride (27 mg, 0.13 mmol) was added. The reaction was stirred overnight then purified by silica gel chromatography using a gradient of increasing ethyl acetate in dichloromethane to provide the title compound.
ES/MS: 548.3 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1H), 8.67 (d, J = 2.2 Hz, 1H), 8.61 (d, J = 4.8 Hz, 1H), 8.02 - 7.95 (m, 1H), 7.77 (s, 1H), 7.64 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.52 - 4.32 (m, 2H), 3.94 (qd, J = 9.1, 4.0 Hz, 3H), 3.59 - 3.41 (m, 1H), 3.40 - 3.33 (m, 1H), 3.25 (d, J = 7.0 Hz, 1H), 2.88 (d, J = 15.4 Hz, 1H), 2.67 - 2.51 (m, 2H), 2.51 - 2.35 (m, 1H), 1.99 (q, J = 10.0, 8.3 Hz, 1H), 1.29 (t, J = 1.5 Hz, 6H).
Procedure 76: Example 702:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- -(((lr,3R)-3-((oxetan-3-ylamino)methyl)cyclobutyl)amino)nicotinamide
Figure imgf000220_0001
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lr,3R)-3-((oxetan-3-ylamino)methyl)cyclobutyl)amino)nicotinamide. To a mixture of 4-(((lr,3R)-3-(aminomethyl)cyclobutyl)amino)-6-(3-cyanopyrrolo[l,2- b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide hydrochloride (31.9 mg, 0.06 mmol), 3-oxetanone (0.02 ml, 0.32 mmol) and Triethylamine (0.01 ml, 0.06 mmol) in 0.2M DCE (0.32 ml) and 0.2M THF (0.32 ml) was added Acetic acid glacial (0.02 ml, 0.33 mmol) and the reaction was stirred for 3 hours at room
temperature. Then, sodium cyanoborohydride (20.17 mg, 0.32 mmol) was added and the reaction was stirred at 55 °C overnight. Saturated sodium bicarbonate was added and the product was extracted into DCM, dried over anhydrous sodium sulfate, filtered, concentrated and purified by RP-HPLC HPLC (eluent: water / MeCN *0.1% TFA). ES/MS: 522.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.1 Hz, 1H), 8.69 (s, 1H), 8.64 (s, 1H), 7.99 (d, J = 5.1 Hz, 1H), 7.70 (s, 1H), 7.24 (d, J = 5.0 Hz, 1H), 4.97 (t, J = 7.5 Hz, 1H), 4.72 (dd, J = 8.1, 5.2 Hz, 1H), 4.57 - 4.36 (m, 3H), 4.07 - 3.84 (m, 2H), 3.72 - 3.39 (m, 2H), 3.29 (d, J = 8.0 Hz, 2H), 2.83 (d, J = 5.3 Hz, 1H), 2.67 - 2.39 (m, 4H), 1.32 (d, J = 1.6 Hz, 6H).
Procedure 77: Example 704:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(((lr,3R)-3-((4-cyclopropyl-lH-l,2,3- triazol-l-yl)methyl)cyclobutyl)amino)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide
Figure imgf000221_0001
4-(((lr,3R)-3-(azidomethyl)cyclobutyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7- yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide. To an ice water bath chilled mixture of 4-(((lr,3R)-3-(aminomethyl)cyclobutyl)amino)-6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide hydrochloride (50 mg, 0.1 mmol), DMAP (14.6 mg, 0.12 mmol) and N-Ethyldiisopropylamine (34.7 μΐ, 0.2 mmol) in 0.9 mL of acetonitrile was added hexafluoro-16-phosphane, 2-azido-l,3-dimethyl-4,5-dihydro-lH-imidazol-3-ium salt (ADMP, 34.08 mg, 0.12 mmol). The mixture was warmed to 30 °C and stirred overnight, then for 1 hour at 40 °C. This solution was cooled to room temperature and used without further processing.
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(((lr,3R)-3-((4-cyclopropyl-lH-l,2,3- triazol-l-yl)methyl)cyclobutyl)amino)-N-((R)-2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide (Example 704). Half of the solution containing 4-(((lr,3R)- 3-(azidomethyl)cyclobutyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide from the step above was diluted with ImL THF. To this solution was added 0.5M 10% CuS04 (0.1 ml), copper (9 mg), and finally ethynylcyclopropane, 0.4M in THF (0.12 ml). After stirring overnight, the mixture was concentrated, then diluted with 1.8 mL methanol for purification by RP-HPLC HPLC (eluent: water / MeCN *0.1% TFA).
ES/MS: 558.2 [M+H+].
1H NMR (400 MHz, Acetonitrile-d3) δ 8.68 (s, 1H), 8.60 (d, J = 1.9 Hz, 2H), 8.07 (d, J = 5.3 Hz, 1H), 7.54 (d, J = 6.4 Hz, 2H), 7.18 (d, J = 5.1 Hz, 1H), 4.52 (d, J = 7.6 Hz, 2H), 4.42 - 4.21 (m, 1H), 3.61 - 3.39 (m, 1H), 1.27 (m, 7H), 1.02 - 0.87 (m, 2H), 0.87 - 0.70 (m, 2H).
Procedure 78: Example 706:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lr,3R)-3-(methoxymethyl)cyclobutyl)amino)nicotinamide
Figure imgf000222_0001
tert-butyl ((lr,3r)-3-(methoxymethyl)cyclobutyl)carbamate A mixture of tert-butyl ((lr,3r)-3-(hydroxymethyl)cyclobutyl)carbamate (230 mg, 1.14 mmol), 11 mL acetonitrile, Silver oxide (141.55 mg, 1.14 mmol), and iodomethane (11.49 ml, 97.14 mmol) was heated at 40 °C for 26 hours. The mixture was allowed to cool to room temperature and was filtered. The filtrate was concentrated and then further dried under reduced pressure to provide the crude product, which was used without further purification. (lr,3r)-3-(methoxymethyl)cyclobutan-l-amine hydrochloride, tert-butyl ((lr,3r)-3- (methoxymethyl)cyclobutyl)carbamate (246 mg, 1 mmol) and 1.25M HCl in EtOH (4.57 ml) was stirred overnight. The mixture was concentrated and diethyl ether was added. The mixture was sonicated briefly and the resulting solid was filtered and washed with a small amount of diethyl ether to provide the product.
6-chloro-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(((lr,3R)-3- (methoxymethyl)cyclobutyl)amino)nicotinamide. (R)-4,6-dichloro-N-(2-fluoro-3- hydroxy-3-methylbutyl)nicotinamide 1 (50 mg, 0.17 mmol), (lr,3r)-3- (methoxymethyl)cyclobutan-l-amine hydrochloride (70% purity, 44.04 mg, 0.2 mmol), N,N-Diisopropylethylamine (0.12 ml, 0.68 mmol) and DMA (0.17 ml) were heated in the microwave at 160 °C for 10 minutes. The reaction mixture was chromatographed using a 25-100% ethyl acetate in hexanes gradient to obtain the product.
ES/MS: 374.3 [M+H+].
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)- 4-(((lr,3R)-3-(methoxymethyl)cyclobutyl)amino)nicotinamide (Example 706). 6- chloro-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)-4-(((lr,3R)-3- (methoxymethyl)cyclobutyl)amino)nicotinamide(19 mg, 0.058 mmol), 7-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (20.52 mg, 0.076 mmol), XPhos Pd G3 (4.44 mg, 0.01 mmol), 2M Potassium phosphate tribasic (0.05 ml), and 0.15M DME (0.32 ml) were degassed together for 1 minute, then heated at 120 °C in the microwave for 15 minutes. The crude mixture was purified by RP- HPLC HPLC (eluent: water / MeCN *0.1% TFA).
ES/MS: 481.3 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.1 Hz, 1H), 8.69 (s, 1H), 8.59 (s, 1H), 8.00 (d, J = 5.1 Hz, 1H), 7.67 (s, 1H), 7.24 (d, J = 5.2 Hz, 1H), 6.96 (d, J = 4.6 Hz, 1H), 4.57 - 4.35 (m, 2H), 4.07 - 3.87 (m, 1H), 3.59 (d, J = 6.5 Hz, 2H), 3.45 (s, 3H), 3.16 (s, 1H), 2.77 - 2.65 (m, 1H), 2.54 (d, J = 11.7 Hz, 2H), 2.33 (d, J = 13.6 Hz, 2H), 1.33 - 1.31 (m, 6H). Procedure 79: Example 830:
Methyl (((lR,3r)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((lr,4R)-4-
(cyclopropanecarboxamido)cyclohexyl)carbamoyl)pyridin-4- yl)amino)cyclobutyl)methyl)carbamate
Figure imgf000224_0001
tert-butyl ((lR,4r)-4-(6-chloro-4-(((lr,3R)-3-
(((methoxycarbonyl)amino)methyl)cyclobutyl)amino)nicotinamido)cyclohexyl)carb amate: A microwave vial was charged with tert-butyl ((lr,4r)-4-(4,6- dichloronicotinamido)cyclohexyl)carbamate (obtained as described in Procedure 61) (60.0 mg, 0.16 mmol), methyl (((lr,3r)-3-aminocyclobutyl)methyl)carbamate hydrochloride (45.1 mg, 0.23 mmol), and cesium carbonate (201.4 mg, 0.62 mmol). Butyronitrile (1.0 mL) was added to the vial, and the vial was sealed and heated thermally at 100 °C for 15 hours. The reaction mixture was cooled, diluted with MeOH, filtered through a plug of Celite, and concentrated in vacuo. The resulting residue was purified by silica gel chromatography (eluent: MeOH/DCM) to provide the product. ES/MS: 510.2 [M+H+]. tert-butyl ((lR,4r)-4-(6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(((lr,3R)-3- (((methoxycarbonyl)amino)methyl)cyclobutyl)amino)nicotinamido)cyclohexyl)carb amate:
A microwave vial was charged with tert-butyl ((lR,4r)-4-(6-chloro-4-(((lr,3R)-3- (((methoxycarbonyl)amino)methyl)cyclobutyl)amino)nicotinamido)cyclohexyl)carbamat e (44.5 mg, 0.087 mmol), 7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2- b]pyridazine-3-carbonitrile (30.5 mg, 0.11 mmol), XPhos Pd G3 (7.4 mg, 0.0087 mmol), and potassium phosphate (37.0 mg, 0.17 mmol). DME (1.5 mL) and water (0.35 mL) were added, and solution was degassed with bubbling argon for 60 seconds. The vial was sealed and heated in a microwave reactor at 125 °C for 25 minutes. Upon completion, the reaction mixture was cooled, diluted with MeOH, filtered through a plug of Celite, and concentrated in vacuo to provide the crude product which was used without additional purification.
ES/MS: 617.4 [M+H+]. methyl (((lR,3r)-3-((5-(((lr,4R)-4-aminocyclohexyl)carbamoyl)-2-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)pyridin-4- yl)amino)cyclobutyl)methyl)carbamate hydrochloride: Crude tert-butyl ((lR,4r)-4-(6- (3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-(((lr,3R)-3- (((methoxycarbonyl)amino)methyl)cyclobutyl)amino)nicotinamido)cyclohexyl)carbamat e (53.5 mg, 0.087 mmol) was taken in 4M HC1 in Dioxane. The reaction mixture was stirred at room temperature for 2 hours. Et20 (3.0 mL) was added, and the reaction mixture was stirred at room temperature for 15 minutes. The reaction mixture was concentrated in vacuo to provide the crude product which was used without purification. ES/MS: 517.4 [M+H+]. methyl (((lR,3r)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((lr,4R)-4- (cyclopropanecarboxamido)cyclohexyl)carbamoyl)pyridin-4- yl)amino)cyclobutyl)methyl)carbamate (Example 830): Crude methyl (((lR,3r)-3-((5- (((lr,4R)-4-aminocyclohexyl)carbamoyl)-2-(3-cyanopyrrolo[l,2-b]pyridazin-7- yl)pyridin-4-yl)amino)cyclobutyl)methyl)carbamate hydrochloride (44.8 mg, 0.087 mmol) was taken in DMF (1.0 mL). Triethylamine (48.4 μί, 0.35 mmol) was added followed by cyclopropanecarbonyl chloride (12.6 μί, 0.14 mmol). The reaction mixture was filtered and directly purified by RP-HPLC (eluent: water / MeCN *0.1% TFA) to provide the product as the trifluoroacetate salt.
ES/MS: 585.8 [M+H+].
1H NMR (400 MHz, Methanol-d4) δ 8.85 - 8.71 (m, 2H), 8.56 (s, 1H), 7.98 (d, J = 5.0 Hz, 1H), 7.82 (s, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.52 - 4.31 (m, 1H), 4.05 - 3.81 (m, 1H), 3.82 - 3.58 (m, 4H), 3.36 (d, J = 7.4 Hz, 2H), 2.71 - 2.52 (m, 1H), 2.53 - 2.41 (m, 2H), 2.33 - 2.21 (m, 2H), 2.17 - 1.89 (m, 4H), 1.67 - 1.29 (m, 5H), 0.90 - 0.79 (m, 2H), 0.78 - 0.67 (m, 2H).
Procedure 80: Example 888: methyl (R)-(5-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)pyridin-2-yl)carbamate:
Figure imgf000226_0001
(R)-4-((6-aminopyridin-3-yl)amino)-6-chloro-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide
(R)-4,6-dichloro-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide (50 mg, 0.169 mmol) and methyl (5-aminopyridin-2-yl)carbamate (38 mg, 0.227 mmol) were added to a vial followed by NMP (1.5 mL) and DIPEA (0.075 mL, 0.431 mmol). The resulting solution was heated to 160 °C for 4 hr. The reaction mixture was then poured into water and extracted with EtOAc. The organic layer was dried, filtered and concentrated, then purified by RP-HPLC (eluent: water / MeCN *0.1% TFA). The product fractions were combined and neutralized with saturated NaHC03 solution to give product.
ES/MS: 368.1 (M+).
1H NMR (400 MHz, Methanol-d4) δ 8.39 (s, 1H), 7.85 (d, J = 2.6 Hz, 1H), 7.43 (dd, J = 8.8, 2.6 Hz, 1H), 6.70 (d, J = 8.8 Hz, 1H), 6.56 (s, 1H), 4.45 (ddd, J = 49.1, 9.2, 2.2 Hz, 1H), 3.92 (ddd, J = 35.9, 14.5, 2.3 Hz, 1H), 3.58 - 3.41 (m, 1H), 1.30 (d, J = 1.7 Hz, 6H). Intermediate 80A: To a solution of (R)-4-((6-aminopyridin-3-yl)amino)-6-chloro-N-(2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide (50 mg, 0.033 mmol) in THF (2 ml), was added NaH (1.58 mg, 60% 0.045 mmol). After 10 min, added methyl chloroformate (0.01 ml, 0.13 mmol). After 1 hr, the reaction was diluted with EtOAc and washed brine. The organic layer was dried, filtered and concentrated to give the desired product.
ES/MS: 484.1 (M+). methyl (R)-(5-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)pyridin-2-yl)car bamate (Example 888) : Intermediate 80A (0.014 g, 0.05rnmol) and 7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-
2- yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (0.013 g, 0.027 mmol) were added to a microwave vial followed by DME (1.5 mL), XPhos Pd G3 (2.6 mg, 0.003 mmol) and K3PO4 (0.5M in water, 0.15 mL, 0.075 mmol). The resulting mixture was purged with argon for 2 minutes, sealed and heated to 100 °C for 2 hr. The reaction mixture was filtered and purified by RP-HPLC (eluent: water / MeCN *0.1% TFA). The product fractions were combined and lyophilized to give the final product as a TFA salt.
ES/MS: 533.2 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.74 (s, 1H), 8.58 (d, J = 2.1 Hz, 1H), 8.40 (s, 1H), 8.13 (d, J = 8.8 Hz, 1H), 8.07 (s, 1H), 7.91 (d, J = 9.0 Hz, 1H), 7.84 (d, J = 5.1 Hz, 1H), 7.19 (d, J = 5.1 Hz, 1H), 4.50 (dd, J = 48.9, 9.3 Hz, 1H), 4.12 - 3.89 (m, 1H), 3.83 (d, J = 10.7 Hz, 2H), 3.61 - 3.43 (m, 1H), 1.32 (d, J = 9.6 Hz, 6H).
Procedure 81: Example 793:
N-(((lR,3r)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy-
3- methylbutyl)carbamoyl)pyridin-4-yl)amino)cyclobutyl)methyl)-4- methylpiperazine-l-carboxamide
Figure imgf000227_0001
N-(((lR,3r)-3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-(((R)-2-fluoro-3-hydroxy- 3-methylbutyl)carbamoyl)pyridin-4-yl)amino)cyclobutyl)methyl)-4- methylpiperazine-l-carboxamide (Example 793): To a slurry of 4-(((lr,3R)-3- (aminomethyl)cyclobutyl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-((R)-2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide bis-hydrochloride (14 mg, 0.03 mmol) in THF (0.3 mL) at 0 °C was added 4-nitrophenyl chloroformate (8 mg, 0.04 mmol) and N- ethyldiisopropylamine (0.04 mL, 0.23 mmol). The resulting solution was then stirred for 1 hour at 0 °C before 1-methylpiperazine (15 uL, 0.14 mmol) was added. The solution was stirred at room temperature for 4 hours and diluted with DMF. Volatiles were removed in vacuo and the resulting solution was purified by RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 592.4 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.70 (m, 2H), 8.59 (s, 1H), 7.99 (d, J = 5.1 Hz, 1H), 7.84 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.53 - 4.33 (m, 2H), 4.23 (s, 2H), 3.92 (ddd, J = 36.4, 14.5, 2.1 Hz, 1H), 3.57 - 3.46 (m, 1H), 3.44 (d, J = 7.8 Hz, 2H), 3.27 - 3.02 (m, 6H), 2.92 (s, 3H), 2.57 (td, J = 8.3, 3.9 Hz, 1H), 2.47 (ddt, J = 11.3, 7.6, 3.5 Hz, 2H), 2.25 (dtd, J = 12.7, 7.1, 2.3 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
19F NMR (376 MHz, Methanol-d4) δ -195.76 (ddd, J = 51.1, 36.6, 16.3 Hz).
Procedure 82: Example 803:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2]octan-l- yl)amino)-N-(3-(methylamino)-3-oxopropyl)nicotinamide
Figure imgf000228_0001
Ethyl 3-(6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2]octan- l-yl)amino)nicotinamido)propanoate: Ethyl 3-(6-(3-cyanopyrrolo[l,2-b]pyridazin-7- yl)-4-((4-hydroxybicyclo[2.2.2]octan- l-yl)amino)nicotinamido)propanoate was prepared according to Procedure 3 using the appropriate starting materials. 3-(6-(3-Cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2]octan-l- yl)amino)nicotinamido)propanoic acid: Ethyl 3-(6-(3-cyanopyrrolo[l,2-b]pyridazin- 7-yl)-4-((4-hydroxybicyclo[2.2.2]octan- l-yl)amino)nicotinamido)propanoate (180 mg, 0.36 mmol) and lithium iodide (482 mg, 3.6 mmol) were combined in pyridine (3.5 mL) and heated to 180 °C (MW) for 45 min and then 30 min. The resulting solution was diluted with IN aqueous hydrochloric acid and extracted 3 times with CH2Cl2/MeOH (10:1). The resulting aqueous layer was then filtered and the resulting ppt was combined with the collected organic layers and concentrated to dryness. The resulting crude hydrochloride salt was used without further purification.
ES/MS: 475.4 (M+H+).
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2]octan-l- yl)amino)-N-(3-(methylamino)-3-oxopropyl)nicotinamide (Example 803): To a solution of 3-(6-(3-Cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamido)propanoic acid hydrochloride (47 mg, 0.09 mmol) in DMF (1 mL) was added methylamine (2M in THF, 0.23 mL, 0.46 mmol) and HATU (45 mg, 0.118 mmol). The resulting solution was stirred at room temperature for 1 hour and the mixture was purified by RP-HPLC (eluent: water / MeCN
*0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 488.5 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1H), 8.72 (d, J = 2.1 Hz, 1H),
8.50 (s, 1H), 8.29 (s, 1H), 7.95 (d, J = 5.1 Hz, 1H), 7.25 (d, J = 5.1 Hz, 1H), 3.64 (t, J =
6.6 Hz, 2H), 2.76 (s, 3H), 2.53 (t, J = 6.7 Hz, 2H), 2.27 (dd, J = 10.4, 5.7 Hz, 6H), 1.93
(dd, J = 10.3, 5.7 Hz, 6H). Procedure 83: Example 965:
(R)-4-((6-chloropyridin-3-yl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2-
Figure imgf000229_0001
(R)-6-bromo-4-((6-chloropyridin-3-yl)amino)-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide: To a mixture of (R)-6-bromo-4-chloro-N-(2-fluoro-3- hydroxy-3-methylbutyl)nicotinamide (100 mg, 0.29 mmol), 6-chloropyridin-3 -amine (49 mg, 0.38 mmol) and Cesium carbonate (192 mg, 0.60 mmol) was added 2.0 mL of ACN. The reaction mixture was stirred at 90 °C overnight after which it was cooled to room temperature. The reaction mixture was partitioned between EtOAc and water. The organic layer was separated, washed with brine, dried over Na2S04. Filtered and concentrated. The crude was purified by reverse phase high pressure liquid
chromatography (eluent: water / MeCN *0.1% TFA). Product fractions were combined, concentrated and then basified by sodium bicarbonate solution and extracted with ethyl acetate (3x) to provide the title compound as a free base.
ES/MS: 433.1 and 431.5 [M+H+].
(R)-4-((6-chloropyridin-3-yl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide (Example 965): A mixture of (R)-6- bromo-4-((6-chloropyridin-3-yl)amino)-N-(2-fluoro-3-hydroxy-3- methylbutyl)nicotinamide (57 mg, 0.13 mmol), 7-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)pyrrolo[l,2-b]pyridazine-3-carbonitrile (1-1) (51 mg, 0.19 mmol), XPhos Pd G3 (11 mg), and 2M Potassium phosphate tribasic (0.14 ml) in 1.3 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 50 °C for 20 minutes. The crude material was purified RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 494.3 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 1H), 8.71 (d, J = 2.2 Hz, 1H), 8.60 (d, J = 2.2 Hz, 1H), 8.54 (dd, J = 2.8, 0.7 Hz, 1H), 8.12 (s, 1H), 7.97 (dd, J = 8.5, 2.8 Hz, 1H), 7.85 (d, J = 5.1 Hz, 1H), 7.68 (dd, J = 8.5, 0.7 Hz, 1H), 7.16 (d, J = 5.1 Hz, 1H), 4.46 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 3.99 (ddd, J = 36.4, 14.6, 2.1 Hz, 1H), 3.53 (ddd, J = 16.2, 14.6, 9.3 Hz, 1H), 1.30 (d, J = 1.7 Hz, 6H).
Procedure 84: Example 972:
(R)-4-((5-(lH-pyrazol-4-yl)pyrazin-2-yl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin- 7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide
Figure imgf000231_0001
(R)-4-((5-(lH-pyrazol-4-yl)pyrazin-2-yl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin- 7-yl)-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide (Example 972): A mixture of (R)-4-((5-chloropyrazin-2-yl)amino)-6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-N-(2- fluoro-3-hydroxy-3-methylbutyl)nicotinamide (15 mg, 0.03 mmol), tert-butyl 4-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-pyrazole-l-carboxylate (18 mg, 0.06 mmol), XPhos Pd G3 (3 mg), and 2M Potassium phosphate tribasic (0.03 ml) in 0.3 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 30 minutes. The crude material was purified RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 527.2 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 10.04 (s, 1H), 8.84 (d, J = 1.5 Hz, 1H), 8.80 (s, 1H), 8.75 (d, J = 2.2 Hz, 1H), 8.70 (d, J = 2.1 Hz, 1H), 8.47 (d, J = 1.4 Hz, 1H), 8.24 (s, 2H), 7.93 (d, J = 4.9 Hz, 1H), 7.19 (d, J = 5.0 Hz, 1H), 4.49 (ddd, J = 49.3, 9.1, 1.9 Hz, 1H), 4.00 (ddd, J = 36.1, 14.7, 1.8 Hz, 1H), 3.65 - 3.48 (m, 1H), 1.32 (s, 6H).
Procedure 85: Example 962:
Figure imgf000232_0001
3-(6-chloro-4-((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamido)-2,2- difluoropropanoic acid: Made in the same manner as (6-chloro-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinoyl)glycine in Procedure 49 substituting methyl 3-amino-2,2-difluoropropanoate.
3-(6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2]octan-l- yl)amino)nicotinamido)-2,2-difluoropropanoic acid: A mixture of 3-(6-chloro-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamido)-2,2-difluoropropanoic acid
(140 mg, 0.34 mmol), 7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrrolo[l,2- b]pyridazine-3-carbonitrile (1-1) (126 mg, 0.47 mmol), XPhos Pd G3 (29 mg), and 2M Potassium phosphate tribasic (0.34 ml) in 1.7 mL DME was degassed with argon for 3 minutes, then capped and heated under microwave conditions at 120 °C for 20 minutes. The crude material was purified RP-HPLC (eluent: water / MeCN *0.1 % TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 511.3 (M+H+).
7-(5-((3-(dimethylamino)-2,2-difluoro-3-oxopropyl)carbamoyl)-4-((4- hydroxybicyclo[2.2.2]octan-l-yl)amino)pyridin-2-yl)pyrrolo[l,2-b]pyridazine-3- carboxamide (Example 962): To a solution of 3-(6-(3-carbamoylpyrrolo[l,2- b]pyridazin-7-yl)-4-((4-hydroxybicyclo[2.2.2]octan-l-yl)amino)nicotinamido)-2,2- difluoropropanoic acid (83 mg, 0.15 rnmol) in DMF (0.75 niL) was added 2M
Dimethylamine (0.15 ml), HATU (85 mg, 0.22 rnmol), and DIPEA (0.13 mL, 0.76 rnmol). The resulting mixture was stirred at room temperature for 18 hours and subsequently diluted with EtOAc. In addition to the expected HATU coupling, hydrolysis of the nitrile group was also observed and therefore that product was isolated. The resulting solution was washed with 50% aqueous NH4C1 (2 times) The resulting aqueous layers were back-extracted with EtOAc and the combined organic layers were dried over MgS04 and concentrated to dryness. The crude material was then purified via RP-HPLC (eluent: water / MeCN *0.1% TFA) to yield the product as a trifluoroacetate salt.
ES/MS: 556.2 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 2.3 Hz, 1H), 8.59 (d, J = 2.3 Hz, 1H), 8.52 (s, 1H), 8.40 (s, 1H), 7.96 (d, J = 5.2 Hz, 1H), 7.23 (d, J = 5.0 Hz, 1H), 3.96 (t, J = 13.7 Hz, 2H), 3.48 (q, J = 7.1 Hz, 4H), 3.16 - 3.10 (m, 1H), 2.99 (s, 1H), 2.85 (s, 1H), 2.26 (t, J = 7.9 Hz, 6H), 2.02 (s, 1H), 1.90 (t, J = 7.9 Hz, 6H), 1.36 (dd, J = 6.7, 3.2 Hz, 2H), 1.28 (s, 1H), 1.17 (t, J = 7.0 Hz, 5H), 0.92 - 0.84 (m, 1H). Procedure 86: Example 756 and Example 757:
Figure imgf000233_0001
Methyl (R)-(6-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)spiro[3.3]heptan-2-yl)carbamate:
Methyl (R)-(6-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)spiro[3.3]heptan-2-yl)carbamate (14 mg ) as a mixture of two isomers was separated using an SFC AD-H column, co-solvent: 30% IPA/DEA.
Diastereomer 1 Example 756:
ES/MS: 550.3 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.68 (d, J = 2.2 Hz, 1H), 8.55 (s, 1H), 7.98 (d, J = 5.0 Hz, 1H), 7.69 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.35 (dd, J = 9.3, 2.1 Hz, 1H), 4.26 (q, J = 7.7 Hz, 1H), 4.06 - 3.83 (m, 2H), 3.61 (s, 3H), 3.58 - 3.37 (m, 1H), 2.81-2.72 (m, J = 11.4 Hz, 1H), 2.60 (ddt, J = 17.5, 11.8, 6.7 Hz, 2H), 2.35 (dt, J = 12.2, 6.1 Hz, 1H), 2.24 - 1.96 (m, 4H), 1.28 (d, J = 1.6 Hz, 6H).
Diastereomer 2 Example 757:
ES/MS: 550.3 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1H), 8.68 (d, J = 2.2 Hz, 1H), 8.55 (s, 1H), 7.98 (d, J = 5.1 Hz, 1H), 7.69 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.42 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 4.27 (p, J = 7.6 Hz, 1H), 4.12 - 3.83 (m, 2H), 3.61 (s, 3H), 3.57 - 3.36 (m, 2H), 2.79 (t, J = 5.9 Hz, 1H), 2.60 (ddt, J = 17.2, 11.7, 6.5 Hz, 2H), 2.42 - 2.26 (m, 1H), 2.24 - 2.06 (m, 3H), 2.02 (s, 1H), 1.28 (d, J = 1.7 Hz, 6H). Procedure 87: Example 764 and Example 765:
Figure imgf000234_0001
Methyl (R)-((3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)-l-fluorocyclobutyl)methyl)carbamate:
Methyl (R)-((3-((2-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-5-((2-fluoro-3-hydroxy-3- methylbutyl)carbamoyl)pyridin-4-yl)amino)-l-fluorocyclobutyl)methyl)carbamate (160 mg ) as a mixture of two isomers was separated using an IC SFC column, co-solvent: 50% EtOH/DEA.
Diastereomer 1 Example 764:
ES/MS: 542.4 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.79 (s, 1H), 8.62 (s, 1H), 8.54 (s, 1H), 8.03 (s, 1H), 7.90 (d, J = 5.0 Hz, 1H), 7.12 (d, J = 4.9 Hz, 1H), 4.55 - 4.31 (m, 1H), 4.09 - 3.81 (m, 2H), 3.75 (s, 3H), 3.53 (dt, J = 24.8, 7.7 Hz, 3H), 2.97 (d, J = 8.0 Hz, 2H), 2.51 - 2.16 (m, 2H), 1.29 (s, 6H).
Diastereomer 2 Example 765:
ES/MS: 542.4 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 2.2 Hz, 1H), 8.63 (d, J = 2.2 Hz, 1H), 8.58 (s, 1H), 7.95 (d, J = 5.0 Hz, 1H), 7.73 (s, 1H), 7.17 (d, J = 5.0 Hz, 1H), 4.56 - 4.33 (m, 2H), 3.94 (ddd, J = 36.2, 14.6, 2.2 Hz, 1H), 3.62 (s, 3H), 3.53 - 3.40 (m, 3H), 2.89 (ddd, J = 19.0, 14.3, 8.4 Hz, 2H), 2.42 (ddd, J = 19.8, 14.1, 5.7 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
Procedure 88: Example 676 and Example 677:
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((6,7-dihydro-5H-cyclopenta[c]pyridin-6- yl)amino)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide
Figure imgf000235_0001
6-(3-cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((6,7-dihydro-5H-cyclopenta[c]pyridin-6- yl)amino)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide: 6-(3- cyanopyrrolo[l,2-b]pyridazin-7-yl)-4-((6,7-dihydro-5H-cyclopenta[c]pyridin-6- yl)amino)-N-((R)-2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide (75 mg, 0.15 mmol) as a mixture of two isomers was separated using an SFC OD-H column, co-solvent: 30% MeOH/DEA.
Diastereomer 1 Example 676: ES/MS: 500.4 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.73 (m, 2H), 8.72 - 8.59 (m, 3H), 8.06 (d, J = 5.1 Hz, 1H), 8.04 - 7.92 (m, 2H), 7.23 (d, J = 5.1 Hz, 1H), 5.04 (tt, J = 7.4, 5.0 Hz, 1H), 4.38 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 4.01 - 3.73 (m, 3H), 3.58 - 3.35 (m, 3H), 1.25 (d, J = 1.7 Hz, 6H).;
Diastereomer 2 Example 677:
ES/MS: 500.3 (M+H+).
1H NMR (400 MHz, Methanol-d4) δ 8.84 - 8.71 (m, 2H), 8.71 - 8.58 (m, 3H), 8.15 - 7.88 (m, 3H), 7.23 (d, J = 5.0 Hz, 1H), 5.03 (ddd, J = 12.3, 7.4, 5.0 Hz, 1H), 4.38 (ddd, J = 49.0, 9.4, 2.1 Hz, 1H), 4.03 - 3.73 (m, 3H), 3.60 - 3.33 (m, 3H), 1.25 (d, J = 1.6 Hz, 6H).
COMPOUND TABLE The following compounds were prepared according to the Examples and Procedures described herein (and indicated in Table 1 under Example/Procedure) using the appropriate starting material(s) and appropriate protecting group chemistry as needed.
Table 1
Figure imgf000236_0001
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Figure imgf000318_0001
Figure imgf000319_0001
Figure imgf000320_0001
Figure imgf000321_0001
Figure imgf000322_0001
Figure imgf000323_0001
Figure imgf000324_0001
Figure imgf000325_0001
Figure imgf000326_0001
Figure imgf000327_0001
Figure imgf000328_0001
Figure imgf000329_0001
Figure imgf000330_0001
Figure imgf000331_0001
Figure imgf000332_0001
Figure imgf000333_0001
Figure imgf000334_0001
Figure imgf000335_0001
Figure imgf000336_0001
Figure imgf000337_0001
Figure imgf000338_0001
Figure imgf000339_0001
Figure imgf000340_0001
Figure imgf000341_0001
Figure imgf000342_0001
Figure imgf000343_0001
Figure imgf000344_0001
Figure imgf000345_0001
Figure imgf000346_0001
Figure imgf000347_0001
Figure imgf000348_0001
Figure imgf000349_0001
Figure imgf000350_0001
Figure imgf000351_0001
Figure imgf000352_0001
Figure imgf000353_0001
Figure imgf000354_0001
Figure imgf000355_0001
Figure imgf000356_0001
Figure imgf000357_0001
Figure imgf000358_0001
Figure imgf000359_0001
Figure imgf000360_0001
Figure imgf000361_0001
Figure imgf000362_0001
Figure imgf000363_0001
Figure imgf000364_0001
Figure imgf000365_0001
Figure imgf000366_0001
Figure imgf000367_0001
Figure imgf000368_0001
Figure imgf000369_0001
Figure imgf000370_0001
Figure imgf000371_0001
Figure imgf000372_0001
Figure imgf000373_0001
Figure imgf000374_0001
Figure imgf000375_0001
Figure imgf000376_0001
Figure imgf000377_0001
Figure imgf000378_0001
Figure imgf000379_0001
Figure imgf000380_0001
Figure imgf000381_0001
Figure imgf000382_0001
Figure imgf000383_0001
Figure imgf000384_0001
Figure imgf000385_0001
Figure imgf000386_0001
Figure imgf000387_0001
Figure imgf000388_0001
Figure imgf000389_0001
Figure imgf000390_0001
Figure imgf000391_0001
Figure imgf000392_0001
Figure imgf000393_0001
Figure imgf000394_0001
Figure imgf000395_0001
Figure imgf000396_0001
Figure imgf000397_0001
Figure imgf000398_0001
Figure imgf000399_0001
1H NMR
Proton NMR data is shown in table 2.
Table 2
Figure imgf000399_0002
compound 1H-NMR
2.08 - 1.81 (m, 1 H), 1.40 (d, J = 6.4 Hz, 6H).
10 1 H NMR (400 MHz, Methanol-d4) δ 8.84 (s, 1 H), 8.55 (d, J = 11.5 Hz, 2H), 8.34 (s,
1 H), 7.78 (s, 1 H), 7.11 (d, J = 5.0 Hz, 1 H), 4.51 - 4.27 (m, 2H), 3.95 (m, 1 H), 3.50 (td, J = 14.8, 9.4 Hz, 1H), 3.13
(s, 3H), 1.27 (d,J =6.4 Hz, 6H).
11 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (d, J = 2.2 Hz, 1 H), 8.62 (d, J = 2.2 Hz,
1H), 8.56 (s, 1H), 7.87 (s, 1H), 7.83 (d, J =5.0 Hz, 1H), 7.19 (d, J =5.0 Hz, 1H), 4.42 (ddd, J =49.1, 9.3, 2.2 Hz, 1H), 4.10-3.80 (m, 1H), 3.60-3.38 (m, 1H), 1.28 (d, J = 1.6 Hz, 6H).
12 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.86 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.15 (hept, J = 6.2 Hz, 1H), 3.89 (d, J =9.7 Hz, 1H), 3.14 (s, 1H), 2.15 (d, J = 10.2 Hz, 4H), 1.69 - 1.45 (m, 4H), 1.40 (d, J = 6.3 Hz, 6H).
13 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.84 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.15 (hept, J = 6.9, 6.4 Hz, 1H), 3.94-3.81 (m, 1H), 3.73-3.58 (m, 1H), 2.11 - 1.96 (m, 4H), 1.93 (s, 3H), 1.59 - 1.45 (m, 2H), 1.45 - 1.36 (m, 8H).
14 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 0.8 Hz,
1 H), 8.66 (d, J = 2.2 Hz, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.78 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1H), 4.43 (ddd, J =49.1, 9.3, 2.2 Hz, 1H), 4.36-4.26 (m, 1H), 4.16 (s, 2H), 3.93 (ddd, J =36.2, 14.6, 2.2 Hz, 1H), 3.64-3.49 (m, 1H), 2.62-2.50 (m, 2H), 2.47-2.37 (m, 2H), 2.33-2.19 (m, 4H), 1.30 (d, J = 1.7 Hz, 6H).
15 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.63 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.78 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.51 - 4.31 (m, 3H), 4.24 (t, J = 6.4 Hz, 1 H), 3.94 (ddd, J = 36.2, 14.6, 2.2 Hz, 1 H), 3.59-3.45 (m, 1H), 3.00 (s, 3H), 2.48 (dd, J = 13.0, 7.7 Hz, 2H), 2.31 - 2.11 (m, 4H), 2.05 (d, J = 14.6 Hz, 2H), 1.30 (d, J = 1.7 Hz, 6H).
16 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.05 (d, J = 5.1 Hz, 1 H), 7.91 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.52-4.31 (m, 2H), 4.22-4.11 (m, 1H), 3.93 (dd, J = 34.6, 14.4 Hz, 2H), 3.58- 3.38 (m, 2H), 3.17-3.04 (m, 1H), 2.16 (s, 4H), 1.80- 1.53 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
17 1H NMR (400 MHz, Methanol-d4) δ 9.13 (s, 1H), 8.81 -8.75 (m, 1H), 8.53 (s, 1H),
7.97 (d, J = 5.0 Hz, 1H), 7.76 (s, 1H), 7.10 (d, J =5.0 Hz, 1H), 4.43 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 4.16 (p, J = 6.3 Hz, 1H), 3.93 (ddd, J = 36.3, 14.6, 2.1 Hz, 1H), 3.49 (td, J = 15.3, 9.3 Hz, 1H), 1.41 (d, J =6.4 Hz, 6H), 1.29 (d, J = 1.6 Hz, 6H).
18 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.49 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.84 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.15 (p, J = 6.4 Hz, 1H), 3.54 (d, J =6.6 Hz, 2H), 2.83-2.71 (m, 1H), 1.40 (d, J = 6.4 Hz, 6H), 1.38 - 1.26 (m, 1 H), 0.94 - 0.79 (m, 2H).
19 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.1 Hz,
1 H), 8.49 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.84 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.15 (p, J = 6.4 Hz, 1H), 3.54 (d, J =6.6 Hz, 2H), 2.77 (dt, J =7.6, 4.0 Hz, 1H), 1.40 (d, J = 6.4 Hz, 6H), 1.36 - 1.29 (m, 1 H), 0.95 - 0.82 (m, 2H).
20 1H NMR (400 MHz, Chloroform-d) δ 9.77 (d, J = 7.5 Hz, 1H), 9.17 (s, 1H), 8.98 (s,
1 H), 8.49 (d, J = 2.1 Hz, 1 H), 8.32 (d, J = 2.1 Hz, 1 H), 8.03 (d, J = 5.0 Hz, 1 H), 7.78 (s, 1H), 7.09 (d, J =5.0 Hz,
1 H), 4.02 - 3.89 (m, 3H), 3.49 - 3.39 (m, 2H), 1.44 (d, J = 6.4 Hz, 6H).
21 1 H NMR (400 MHz, Chloroform-d) δ 9.89 (d, J = 7.4 Hz, 1 H), 8.80 (s, 1 H), 8.46 (d,
J = 2.1 Hz, 1 H), 8.32 (d, J = 2.1 Hz, 1 H), 8.11 - 7.98 (m, 2H), 7.88 (s, 1 H), 7.84 (d, J = 8.1 Hz, 2H), 7.34 (d, J = 8.0 Hz, 2H), 7.08 (d, J = 5.1 Hz, 1 H), 4.04 - 3.88 (m, 1 H), 3.70 (d, J = 6.3 Hz, 2H), 2.99 (t, J = 6.5 Hz, 2H), 1.45 (d, J = 6.3 Hz, 6H).
22 1H NMR (400 MHz, Chloroform-d) δ 10.02 (d, J =7.4 Hz, 1H), 9.10 (s, 1H), 8.45
(d, J =2.1 Hz, 1H), 8.32 (d, J = 2.1 Hz, 1H), 8.10 (d, J = 5.1 Hz, 1H), 7.99 (d, J = 7.7 Hz, 1 H), 7.94 (s, 1 H), 7.08 (d, J = 5.0 Hz, 1 H), 5.72 - 5.56 (m, 1 H), 3.93 (dq, J = 13.2, 6.6 Hz, 2H), 2.81 (d, J =4.7 Hz, 3H), 2.16-2.00 (m, 3H), 1.95 (d, J = 13.4 Hz, 2H), 1.64 (q, J = 12.5, 12.0 Hz, 2H), 1.43 (d, J =6.4 Hz, 7H).
23 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.1 Hz,
1 H), 8.66 (s, 1 H), 8.04 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.52 - 4.33 (m, 1 H), 4.28 - 4.17 (m, 1 H), 4.02 - 3.83 (m, 1 H), 3.60 - 3.49 (m, 3H), 3.29 - 3.22 (m, 1 H), 2.43 - 2.31 (m, 2H), 1.99 - 1.83 (m, 2H), 1.30 (d, J = 1.7 Hz, 6H).
24 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.65 (s, 1 H), 8.05 - 8.00 (m, 2H), 7.23 (d, J = 5.1 Hz, 1 H), 4.50 - 4.32 (m, 2H), 4.22 (s, 2H), 4.01 - 3.82 (m, 1 H), 3.59 - 3.44 (m, 1 H), 2.49 - 2.39 (m, 2H), 2.35 - 2.18 (m, 4H), 1.94 (t, J = 12.7 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
25 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.69 (s, 1 H), 8.66 (d, compound 1H-NMR
J = 2.2 Hz, 1 H), 8.08 (d, J = 5.1 Hz, 1 H), 8.01 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.95-4.86 (m, 1H), 4.43 (ddd, J =
48.9, 9.3, 2.1 Hz, 1 H), 4.04 - 3.84 (m, 1 H), 3.74 (dd, J = 13.4, 8.0 Hz, 1 H), 3.61 - 3.46 (m, 2H), 3.15 (dd, J = 13.8, 2.6 Hz, 1H), 2.77 (t, J = 11.8 Hz, 1H), 1.86 - 1.74 (m, 1H), 1.71 - 1.61 (m, 1H),
1.30 (d, J = 1.8 Hz, 6H), 1.18-1.04 (m, 1H), 0.91 (q, J =5.7 Hz, 1H).
26 1 H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.57 (m, 3H), 8.01 (d, J = 5.1 Hz, 1 H),
7.99 (s, 1 H), 7.50 - 7.05 (m, 2H), 4.57 - 4.48 (m, 2H), 4.45 - 4.34 (m, 1 H), 4.05 - 3.94 (m, 1H), 3.96-3.84 (m, 1H), 3.73 (dd, J = 13.6, 7.5 Hz, 1H), 3.63-3.45 (m, 1 H), 3.23 (s, 1 H), 1.63 - 1.38 (m, 2H), 1.38 - 1.26 (m, 6H), 1.21 (td, J = 9.0, 5.8 Hz, 1 H), 0.76 (q, J = 5.7 Hz, 1 H).;1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.69 (s, 1 H), 8.66 (d, J = 2.2 Hz, 1 H), 8.08 (d, J = 5.1 Hz, 1 H), 8.01 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.95 - 4.86 (m, 1 H), 4.43 (ddd, J = 48.9, 9.3, 2.1 Hz, 1H), 4.04-3.84 (m, 1H), 3.74 (dd, J = 13.4, 8.0 Hz, 1H), 3.61 -3.46 (m, 2H), 3.15 (dd, J = 13.8, 2.6 Hz, 1 H), 2.77 (t, J = 11.8 Hz, 1 H), 1.86 - 1.74 (m, 1 H), 1.71 - 1.61 (m, 1H), 1.30 (d, J = 1.8 Hz, 6H), 1.18 - 1.04 (m, 1 H), 0.91 (q, J = 5.7 Hz, 1 H).
27 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.68 (s, 1 H), 8.66 (d,
J = 2.2 Hz, 1 H), 8.02 (d, J = 5.0 Hz, 1 H), 7.99 (s, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.27 (s, 1 H), 4.00 - 3.81 (m, 1 H), 3.58 - 3.44 (m, 3H), 3.43 - 3.36 (m, 2H), 2.71 (s, 2H), 2.27 - 2.12 (m, 2H), 2.02 - 1.86 (m, 2H), 1.29 (d, J = 1.7 Hz, 6H).
28 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.74 (s, 1 H), 8.66 (d,
J = 2.2 Hz, 1 H), 8.04 (d, J = 5.1 Hz, 1 H), 7.98 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.45 (dd, J =49.1, 7.2 Hz, 1H), 4.17 (t, J = 5.0 Hz, 1H), 3.94 (ddd, J =35.8, 14.4, 1.8 Hz, 1H), 3.58 (td, J = 15.6, 9.4 Hz, 1H), 3.39 (d, J = 13.7 Hz, 2H), 3.23 (d, J = 13.6 Hz, 2H), 2.71 (s, 2H), 2.35-2.22 (m, 2H), 2.03-1.91 (m, 2H), 1.30 (d, J = 1.7 Hz, 6H).;1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.68 (s, 1 H), 8.66 (d, J = 2.2 Hz, 1 H), 8.02 (d, J = 5.0 Hz, 1 H), 7.99 (s, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.27 (s, 1 H), 4.00 - 3.81 (m, 1 H), 3.58 - 3.44 (m, 3H), 3.43-3.36 (m, 2H), 2.71 (s, 2H), 2.27 - 2.12 (m, 2H), 2.02- 1.86 (m, 2H), 1.29 (d, J = 1.7 Hz, 6H).
29 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.02 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.51 - 4.29 (m, 4H), 3.93 (dd, J = 35.7, 15.2 Hz, 1 H), 3.56 - 3.40 (m, 2H), 3.02 (s, 3H), 2.33-2.17 (m, 3H), 2.07 (t, J =7.2 Hz, 2H), 1.94 - 1.80 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
30 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.71 - 8.67 (m, 1 H),
8.63 - 8.59 (m, 1 H), 8.00 (dd, J = 5.6, 3.2 Hz, 2H), 7.22 (d, J = 5.1 Hz, 1 H), 4.63 - 4.31 (m, 2H), 3.96 (ddd, J =35.8,
14.7, 4.6 Hz, 1H), 3.83-3.59 (m, 1H), 3.59-3.44 (m, 2H), 2.92-2.85 (m, 3H), 1.75 (dt, J = 15.1, 8.2 Hz, 1H), 1.62- 1.42 (m, 1H), 1.30 (d, J = 1.7 Hz, 8H), 1.07 - 0.80 (m, 1H), 0.78-0.63 (m, 1
H).
31 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.69 - 8.66 (m, 2H),
8.05 (d, J = 5.1 Hz, 1 H), 7.93 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.43 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1H), 4.16 (t, J =4.7 Hz, 1H), 4.04-3.85 (m, 1H), 3.62-3.51 (m, 1H), 3.51 - 3.43 (m, 2H), 3.20 (dd, J = 11.9, 4.8 Hz, 2H), 2.95 - 2.90 (m, 3H), 2.59 (s, 2H), 2.12-2.02 (m, 2H), 1.96- 1.87 (m, 2H), 1.29 (d, J = 1.7 Hz, 6H).
32 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.72 - 8.65 (m, 2H),
8.05 (d, J = 5.1 Hz, 1 H), 7.92 (s, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.53 - 4.35 (m, 2H), 4.20 (s, 1H), 3.94 (ddd, J =36.5, 14.5, 2.1 Hz, 1H), 3.64-3.50 (m, 1H), 3.47-3.39 (m, 1H), 3.27-3.19 (m, 2H), 2.65 (ddd, J = 14.8, 11.0, 3.6 Hz, 1H), 2.17 (d, J = 11.8 Hz, 1H), 2.02 (d, J = 11.9 Hz, 1H), 1.68 (dt, J = 14.9, 4.0 Hz, 1H), 1.30 (d, J = 1.7 Hz, 6H).
33 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.30 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 3.93 (ddd, J =36.6, 14.6, 2.1 Hz, 1H), 3.55 - 3.42 (m, 1 H), 1.63 (s, 9H), 1.29 (d, J = 1.7 Hz, 6H).
34 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.73 (d, J = 2.2 Hz, 1 H), 8.65 (d,
J = 2.2 Hz, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.83 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.16 (p, J = 6.5 Hz, 1H), 3.25 (s, 3H), 1.41 (d, J =6.4 Hz, 6H).
35 1 H NMR (400 MHz, Methanol-d4) δ 8.63 (s, 1 H), 8.55 (d, J = 2.2 Hz, 1 H), 8.48 (d,
J =2.3 Hz, 1H), 8.15 (s, 1H), 7.79 (d, J =4.9 Hz, 1H), 7.08 (d, J = 4.8 Hz, 1H), 4.40 (d, J = 8.2 Hz, 1 H), 4.00 (d, J = 8.2 Hz, 1 H), 3.92 (p, J = 6.4 Hz, 1 H), 3.64 - 3.49 (m, 2H), 1.37 (d, J = 6.4 Hz, 6H), 1.34 (s, 3H).
36 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.84 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), compound 1H-NMR
4.58 (ddd, J = 9.6, 7.5, 3.8 Hz, 1 H), 4.15 (p, J = 6.4 Hz, 1 H), 4.05 - 3.90 (m, 2H), 3.84 (td, J = 8.3, 5.8 Hz, 1 H), 3.77 (dd, J = 9.3, 3.5 Hz, 1 H), 2.39 - 2.26 (m, 1 H), 2.09 - 1.90 (m, 1 H), 1.40 (d, J = 6.4 Hz, 6H).
37 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.84 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.58 (dq, J = 9.7, 3.8 Hz, 1 H), 4.15 (p, J = 6.4 Hz, 1 H), 4.08 - 3.89 (m, 2H), 3.84 (td, J =8.4, 5.9 Hz, 1H), 3.77 (dd, J =9.3, 3.5 Hz, 1H), 2.33 (dtd, J = 13.0, 8.0, 6.7 Hz, 1 H), 2.11 - 1.91 (m, 1 H), 1.40 (d, J = 6.5 Hz, 6H).
38 1 H NMR (400 MHz, DMS0-d6) δ 8.81 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.3 Hz, 1 H),
8.62 (s, 1H), 8.49 (dd, J = 13.9, 6.1 Hz, 2H), 8.04 (s, 1H), 7.80 (d, J = 4.8 Hz, 1H), 7.08 (d, J = 4.7 Hz, 1 H), 3.76 (h, J = 6.4 Hz, 1 H), 2.75 (d, J = 4.4 Hz, 3H), 1.25 (d, J =6.4 Hz, 6H).
39 1 H NMR (400 MHz, DMS0-d6) δ 8.81 (d, J = 2.2 Hz, 1 H), 8.72 (d, J = 7.2 Hz, 1 H),
8.69 (d, J = 2.0 Hz, 2H), 8.04 (s, 2H), 7.81 (d, J = 4.8 Hz, 1 H), 7.33 (s, 1 H), 7.08 (d, J = 4.8 Hz, 1 H), 3.76 (h, J = 6.4 Hz, 1 H), 1.25 (d, J = 6.3 Hz, 6H).
40 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.1 Hz,
1 H), 8.61 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.72 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.53 - 4.29 (m, 2H), 3.95 (ddd, J =
36.3, 14.6, 2.1 Hz, 1H), 3.60-3.40 (m, 1H), 3.25 (s, 1H), 2.88-2.69 (m, 1H), 1.29 (d, J = 1.6 Hz, 6H).2 protons obscured by solvent peaks.
41 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.48 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.82 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.15 (p, J = 6.4 Hz, 1H), 3.55-3.45 (m, 2H), 1.83 - 1.72 (m, 2H), 1.40 (d, J =6.4 Hz, 6H), 1.27 (s, 6H).
42 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.88 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J =49.0, 9.4, 2.0 Hz, 1H), 4.18-4.08 (m, 1H), 4.04-3.83 (m, 3H), 3.66 (t, J = 10.5 Hz, 2H), 3.56-3.41 (m, 1H), 2.10 (d, J = 12.8 Hz, 2H), 1.80 - 1.65 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
43 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (d, J = 2.2 Hz, 1 H), 8.68 (s, 1 H), 8.62 (d,
J =2.2 Hz, 1H), 8.12 (d, J =0.8 Hz, 1H), 8.10 (s, 1H), 7.84 (d, J = 5.0 Hz, 2H), 7.18 (d, J = 5.1 Hz, 1H), 5.67-5.58 (m, 1H), 5.26-5.00 (m, 4H), 4.46 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.09 - 3.84 (m, 1 H), 3.64 - 3.43 (m, 1 H), 1.29 (d, J = 1.7 Hz, 6H).
44 1 H NMR (400 MHz, Methanol-d4) δ 8.59 (d, J = 2.2 Hz, 1 H), 8.34 (d, J = 2.2 Hz,
1H), 8.12 (s, 1H), 7.43 (d, J = 4.8 Hz, 1H), 7.32 (s, 1H), 7.08 (d, J =4.8 Hz, 1H), 4.27 - 4.06 (m, 1 H), 3.99 - 3.78 (m, 4H), 3.79 - 3.60 (m, 1 H), 3.56 - 3.49 (m, 1 H), 2.96 (s, 4H), 1.20 (d, J = 2.0 Hz, 6H).
45 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.49 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.84 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.15 (p, J = 6.4 Hz, 1H), 3.54 (d, J =6.5 Hz, 2H), 2.81 -2.72 (m, 1H), 1.40 (d, J = 6.4 Hz, 6H), 1.37 - 1.28 (m, 1 H), 0.95 - 0.79 (m, 2H).
46 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.55-4.29 (m, 1 H), 4.14 - 4.01 (m, 1H),4.01 -3.85 (m, 1 H), 3.78 - 3.67 (m, 2H), 3.58-3.42 (m, 1 H), 3.20 - 3.08 (m, 2H), 2.91 (s, 3H), 2.32 - 2.14 (m, 2H), 1.91 - 1.71 (m, 2H), 1.28 (d, J = 1.6 Hz, 6H).
47 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.66 (s, 1 H), 8.60 (d,
J = 2.2 Hz, 1 H), 8.08 (s, 1 H), 7.90 (s, 1 H), 7.83 (d, J = 5.1 Hz, 1 H), 7.69 (d, J = 0.9 Hz, 1H),7.17(d, J = 5.1 Hz, 1 H), 4.55 - 4.35 (m, 1 H), 4.04 - 3.91 (m, 1H), 3.98 (s, 3H), 3.61 - 3.43 (m, 1 H), 1.29 (d, J = 1.7 Hz, 6H).
48 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.2 Hz, 1 H), 8.70 (s, 1 H), 8.52 (d,
J =2.2 Hz, 1H), 8.44 (s, 1H), 8.19 (s, 1H), 7.97 (s, 1H), 7.86 (d, J =5.1 Hz, 1H), 7.58 (t, J =59.6 Hz, 1H), 7.18 (d, J = 5.1 Hz, 1H), 4.58-4.36 (m, 1H), 4.07-3.88 (m, 1 H), 3.66 - 3.42 (m, 1 H), 1.30 (d, J = 1.7 Hz, 6H).
49 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.68 (s, 1 H), 8.55 (d,
J =2.2 Hz, 1H), 8.10 (d, J =6.8 Hz, 1H), 8.10 (s, 1H), 7.83 (s, 1H), 7.81 (d, J = 5.1 Hz, 1H), 7.18 (d, J = 5.0 Hz, 1H), 5.06 (q, J = 8.7 Hz, 2H), 4.46 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 4.10-3.85 (m, 1H), 3.61 -3.42 (m, 1H), 1.29 (d, J = 1.7 Hz, 6H).
50 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.1 Hz,
1 H), 8.62 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.74 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.45 (s, 2H), 4.42 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 4.19 (t, J =6.2 Hz, 1H), 3.94 (ddd, J = 36.3, 14.6, 2.2 Hz, 1 H), 3.66 - 3.43 (m, 1 H), 2.50 - 2.31 (m, 2H), 2.23 - 2.03 (m, 4H), 1.85 (d, J = 14.8 Hz, 2H), 1.29 (d, J = 1.7 Hz, 6H).
51 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.35 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J =49.1, 9.3, 2.1 Hz, 1H), 3.93 (ddd, J =36.4, 14.6, 2.1 Hz, 1H), 3.74 (s, 2H), 3.56-3.38 (m, 1H), 1.28 (d, J = 1.7 Hz, 6H), 1.20-1.14 (m, 2H), 1.06 - compound 1H-NMR
0.99 (m, 2H).
52 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.1 Hz,
1 H), 8.50 (s, 1 H), 7.99 (dd, J = 4.9, 1.8 Hz, 1 H), 7.83 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.83 (dd, J = 7.8, 6.0 Hz, 1 H), 4.45 (t, J = 6.2 Hz, 1 H), 4.15 (p, J = 6.5 Hz, 1 H), 3.66 - 3.57 (m, 1 H), 3.59 - 3.42 (m, 1 H), 3.35 (t, J = 7.1 Hz, 1 H), 3.20 - 3.01 (m, 1 H), 2.02 (q, J = 7.3 Hz, 2H), 1.84 - 1.61 (m, 1 H), 1.40 (dd, J =6.4, 1.4 Hz, 8H).
53 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.1 Hz,
1 H), 8.63 (s, 1 H), 8.04 (d, J = 5.0 Hz, 1 H), 7.91 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.68 - 4.61 (m, 1 H), 4.51 - 4.31 (m, 1 H), 4.02 - 3.86 (m, 1 H), 3.82 (dd, J = 10.6, 5.7 Hz, 1H), 3.64-3.40 (m, 4H), 2.97 (s, 3H), 2.52 (td, J = 14.1, 7.6 Hz, 1H), 2.21 (dt, J = 12.7, 6.1 Hz, 1H), 1.28 (d, J = 1.6 Hz, 6H).
54 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.1 Hz,
1 H), 8.62 (s, 1 H), 8.00 (d, J = 5.2 Hz, 1 H), 7.62 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 5.18 - 5.08 (m, 3H), 4.76 - 4.71 (m, 2H), 4.44 (dd, J = 48.6, 8.1 Hz, 1H), 4.12 - 3.84 (m, 1 H), 3.58 - 3.43 (m, 1 H), 1.29 (d, J = 1.6 Hz, 6H).
55 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.24 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.51 - 4.31 (m, 1 H), 4.07 - 3.80 (m, 1 H), 3.54 - 3.39 (m, 1 H), 2.87 (tt, J = 7.2, 3.8 Hz, 1H), 1.28 (d, J = 1.6 Hz, 6H), 1.15 - 1.06 (m, 2H), 0.83-0.74 (m, 2H).
56 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.66 (s, 1 H), 8.59 (d,
J =2.2 Hz, 1H), 8.10 (s, 1H), 7.96 (d, J =0.9 Hz, 1H), 7.82 (d, J = 5.0 Hz, 1H), 7.72 (d, J = 0.9 Hz, 1H), 7.17 (d, J =5.0 Hz, 1H), 4.55-4.36 (m, 1H), 4.27 (q, J = 7.2 Hz, 2H), 4.08 - 3.79 (m, 1 H), 3.59 - 3.44 (m, 1 H), 1.52 (t, J = 7.3 Hz, 3H), 1.29 (d, J = 1.6 Hz, 6H).
57 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.64 (s, 1 H), 8.06 (d, J = 5.1 Hz, 1 H), 7.88 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.52 - 4.29 (m, 2H), 4.18 (t, J = 12.8 Hz, 1 H), 4.08 - 3.84 (m, 2H), 3.82 - 3.63 (m, 2H), 3.55-3.40 (m, 1H), 2.11 -1.91 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
58 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 1 H), 8.72 (d, J = 2.1 Hz, 1 H), 8.66 (s,
1H), 8.63 (d, J =2.2 Hz, 1H), 8.08 (s, 1H), 7.89 (d, J =5.1 Hz, 1H), 7.18 (d, J =5.0 Hz, 1 H), 4.47 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 4.20 (s, 3H), 3.98 (ddd, J = 36.3, 14.6, 2.2 Hz, 1H), 3.68-3.45 (m, 1H), 1.30 (d, J = 1.7 Hz, 6H).
59 1 H NMR (400 MHz, Methanol-d4) δ 9.06 (s, 1 H), 8.73 (s, 1 H), 8.72 (d, J = 2.1 Hz,
1H), 8.69 (s, 1H), 8.60 (d, J = 2.2 Hz, 1H), 8.19 (s, 1H), 7.86 (d, J =5.1 Hz, 1H), 7.17 (d, J = 5.1 Hz, 1H), 4.47 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 3.99 (ddd, J = 36.4, 14.6, 2.1 Hz, 1H), 3.62-3.45 (m, 1H), 1.30 (d, J = 1.7 Hz, 6H).
60 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.1 Hz,
1 H), 8.53 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.82 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.33 (p, J = 8.2 Hz, 1 H), 4.13 (hept, J = 6.4 Hz, 1 H), 3.66 (s, 3H), 3.09 (p, J = 8.3 Hz, 1H), 2.63-2.51 (m, 1H), 2.48 - 2.18 (m, 5H), 2.16-2.01 (m, 2H), 1.39 (d, J = 6.4 Hz, 6H).
61 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.91 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.3, 2.2 Hz, 1 H), 4.29 - 4.17 (m, 1 H), 4.11 (s, 1 H), 3.92 (ddd, J = 36.3, 14.5, 2.1 Hz, 1H), 3.58-3.39 (m, 1H), 2.14-1.84 (m, 3H), 1.82- 1.52 (m, 5H), 1.28 (d, J = 1.6 Hz, 6H).
62 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1 H), 8.50 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.80 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J =49.1, 9.3, 2.0 Hz, 1H), 4.06 (s, 1H), 3.94 (dd, J = 36.5, 14.3 Hz, 1H), 3.64-3.42 (m, 2H), 3.40 (s, 3H), 2.21 (d, J = 13.3 Hz, 1H), 2.05- 1.79 (m, 3H), 1.76 - 1.41 (m, 4H), 1.29 (d, J = 1.7 Hz, 6H).
63 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.53-4.31 (m, 1H), 4.29-4.17 (m, 1H), 4.10 (s, 1H), 4.01 -3.82 (m, 1H), 3.58 - 3.41 (m, 1H), 2.10 - 1.83 (m, 3H), 1.83 - 1.52 (m, 5H), 1.28 (d, J = 1.7 Hz, 6H).
64 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.85 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.08 - 3.80 (m, 2H), 3.61 - 3.39 (m, 1 H), 2.08 (d, J = 12.0 Hz, 2H), 1.82 (d, J = 11.9 Hz, 2H), 1.74- 1.34 (m, 6H), 1.29 (d, J = 1.7 Hz, 6H).
65 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.53 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.85 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 4.06 - 3.76 (m, 3H), 3.58 - 3.38 (m, 1 H), 2.31 (d, J = 12.3 Hz, 1H), 2.12-1.85 (m, 4H), 1.61 -1.33 (m, 3H), 1.28 (d, J = 1.7 Hz, 6H).
66 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), compound 1H-NMR
4.18 (hept, J = 6.4 Hz, 1H), 1.47 (s, 6H), 1.40 (d, J = 6.4 Hz, 6H).
67 1 H NMR (400 MHz, Methanol-d4) δ 8.63 (d, J = 3.0 Hz, 1 H), 8.49 (dd, J = 2.3, 1.1
Hz, 1H), 8.38-8.27 (m, 2H), 7.80 (dd, J = 10.9, 0.9 Hz, 1H), 7.77 (dd, J =4.9, 1.2 Hz, 1H), 7.62 (dd, J = 12.7, 0.9
Hz, 1H),7.02 (d, J = 4.9 Hz, 1 H), 6.35 - 5.87 (m, 1H), 5.33 - 5.17 (m, 1H), 4.46 (ddd, J = 48.8, 9.0, 2.0 Hz, 1 H), 4.11 - 3.81 (m, 1 H), 3.60 - 3.44 (m, 1 H), 1.91 (s, 1H), 1.30 (d, J = 1.6 Hz, 7H), 1.
19-1.03 (m, 2H).
68 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.68 (m, 2H), 8.63 (d, J = 2.2 Hz, 1 H),
8.40 (s, 1H), 7.91 (s, 1H), 7.87 (d, J =5.1 Hz, 1H), 7.34 (d, J = 1.5 Hz, 1H), 7.18 (d, J = 5.1 Hz, 1H), 4.45 (ddd, J =
49.1, 9.3, 2.1 Hz, 1H), 3.97 (ddd, J =36.4, 14.6, 2.2 Hz, 1H), 3.86 (s, 3H), 3.52 (ddd, J = 16.0, 14.5, 9.3 Hz, 1H), 1.29 (d, J = 1.6 Hz, 6H).
69 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.1 Hz,
1 H), 8.47 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.81 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.16 (p, J = 6.4 Hz, 1H), 2.91 (s, 2H), 1.40 (d, J =6.4 Hz, 6H), 1.29 (s, 6H).
70 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.66 (s, 1 H), 8.59 (d,
J =2.2 Hz, 1H), 8.09 (s, 1H), 7.89 (s, 2H), 7.81 (d, J =5.1 Hz, 1H), 7.17 (d, J =5.2 Hz, 1H), 4.46 (dd, J = 48.9, 8.1 Hz, 1H), 3.98 (dd, J =36.8, 14.5 Hz, 1H), 3.59- 3.44 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
71 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.71 - 8.55 (m, 2H),
7.99 (d, J = 5.0 Hz, 1 H), 7.88 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.72 - 4.51 (m, 3H), 4.30-4.21 (m, 2H), 4.15 (hept, J = 6.3 Hz, 1H), 1.40 (d, J =6.4 Hz, 6H).
72 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.85 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.38 - 4.21 (m, 2H), 4.15 (p, J = 6.4 Hz, 1 H), 4.08 - 3.89 (m, 2H), 3.69 (d, J = 6.6 Hz, 2H), 2.92 (qd, J = 9.9, 5.9 Hz, 1 H), 1.40 (d, J = 6.4 Hz, 6H).
73 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.85 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.15 (p, J = 6.4 Hz, 1H), 3.54 (qd,
J = 13.7, 6.4 Hz, 2H), 3.26 - 3.03 (m, 2H), 2.96 - 2.66 (m, 2H), 2.51 - 2.30 (m, 1 H), 2.10-1.83 (m, 1H), 1.40 (d, J = 6.4 Hz, 6H).
74 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.89 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.57-4.31 (m, 1H), 3.94 (dd, J = 36.1, 14.6 Hz, 1 H), 3.75 (qd, J = 14.1, 6.4 Hz, 2H), 3.58 - 3.42 (m, 1 H), 3.44 - 3.21 (m, 2H), 3.22 - 3.06 (m, 1 H), 3.05 - 2.81 (m, 2H), 2.57-2.44 (m, 1H), 2.19-1.92 (m, 1H), 1.29 (d, J = 1.7 Hz, 6H).
75 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.62 (s, 1 H), 8.04 (d, J = 5.1 Hz, 1 H), 7.88 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.43 (ddd, J =48.9, 9.3, 2.1 Hz, 1H), 4.24 (t, J = 10.3 Hz, 1H), 4.05-3.82 (m, 1H), 3.60-3.45 (m, 1H), 3.43-3.32 (m, 2H), 3.20 (d, J = 14.5 Hz, 2H), 2.47 (d, J = 13.8 Hz, 2H), 2.33 (t, J = 11.1 Hz, 2H), 1.29 (d, J = 1.7 Hz, 6H).
76 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.64 (s, 1 H), 8.06 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.96 - 4.75 (m, 1 H), 4.43 (ddd, J =
49.1 , 9.3, 2.1 Hz, 1 H), 3.94 (dd, J = 36.3, 14.7 Hz, 1 H), 3.73 (dd, J = 13.7, 7.5 Hz, 1H), 3.61 -3.16 (m, 4H), 2.80 (td, J = 13.7, 6.1 Hz, 1H), 2.44 (dq, J = 15.2, 8.0 Hz, 1H), 1.29 (d, J = 1.6 Hz, 6
H).
77 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.72 - 8.64 (m, 2H),
8.04 (d, J = 5.0 Hz, 1 H), 7.78 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.82 - 4.71 (m, 3H), 4.59 - 4.20 (m, 3H), 4.06 - 3.85 (m, 1 H), 3.61 - 3.40 (m, 1 H), 1.29 (d, J = 1.6 Hz, 6H).
78 1 H NMR (400 MHz, Methanol-d4) δ 8.92 (d, J = 2.3 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1H), 8.61 (s, 1H), 7.98 (d, J = 5.0 Hz, 1H), 7.84 (s, 1H), 7.12 (d, J =5.0 Hz, 1H), 4.75-4.47 (m, 3H), 4.33-4.21 (m, 2H), 4.16 (p, J =6.3 Hz, 1H), 1.40 (d, J =6.4 Hz, 6H).
79 1 H NMR (400 MHz, Methanol-d4) δ 8.92 (d, J = 2.3 Hz, 1 H), 8.68 (d, J = 2.3 Hz,
1H), 8.54 (s, 1H), 7.98 (d, J = 5.0 Hz, 1H), 7.81 (s, 1H), 7.12 (d, J =5.0 Hz, 1H), 4.30 (dd, J = 14.3, 9.9 Hz, 2H), 4.16 (p, J =6.4 Hz, 1H), 4.00 (dd, J = 14.5, 5.5 Hz, 2H), 3.69 (d, J = 6.5 Hz, 2H), 3.00 - 2.82 (m, 1 H), 1.40 (d, J = 6.4 Hz, 6H).
80 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.1 Hz,
1 H), 8.51 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 3.92 (ddd, J =36.3, 14.5, 2.2 Hz, 1H), 3.73- 3.63 (m, 2H), 3.56 - 3.39 (m, 1 H), 1.98 - 1.85 (m, 2H), 1.39 - 1.23 (m, 12H).
81 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.95 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.49 - 4.36 (m, 1 H), 4.29 - 4.20 (m, 1 H), 4.01 - 3.76 (m, 3H), 3.56 - 3.40 (m, 1 H), compound 1 H-NMR
2.16 - 2.01 (m, 2H), 1.61 (td, J = 12.0, 5.2 Hz, 1 H), 1.51 (t, J = 12.4 Hz, 1 H), 1.41 (s, 3H), 1.28 (d, J = 1.7 Hz, 9H).
82 1 H NMR (400 MHz, Methanol-d4) δ 8.56 (d, J = 6.7 Hz, 3H), 7.99 (s, 1 H), 7.80 (d,
J = 4.9 Hz, 1 H), 7.07 (d, J = 4.9 Hz, 1 H), 4.68 (s, 2H), 4.41 (ddd, J = 48.9, 9.2, 2.3 Hz, 1 H), 4.03 - 3.92 (m, 1 H), 3.92 - 3.77 (m, 1 H), 3.57 - 3.40 (m, 1 H), 3.00 - 2.79 (m, 2H), 2.32 - 2.17 (m, 2H), 1.28 (d, J = 1.7 Hz, 7H).
83 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.69 - 8.63 (m, 2H),
8.03 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.91 (t, J = 7.7 Hz, 3H), 4.81 (dd, J = 8.2, 5.6 Hz, 2H), 4.54 - 4.31 (m, 2H), 4.22 (s, 1 H), 4.05 - 3.81 (m, 1 H), 3.60 - 3.48 (m, 2H), 3.20 - 3.02 (m, 2H), 2.43 (d, J = 13.8 Hz, 2H), 2.12 - 1 .84 (m, 2H), 1.29 (d, J = 1.7 Hz, 6H).
84 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.62 (s, 1 H), 8.04 (d, J = 5.0 Hz, 1 H), 7.94 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 6.20 (tt, J = 55.0, 3.3 Hz, 1 H), 4.43 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.09 (td, J = 15.4, 3.3 Hz, 2H), 3.95 (ddd, J = 36.4, 14.6, 2.1 Hz, 1 H), 3.49 (ddd, J = 15.9, 14.5, 9.4 Hz, 1 H), 1.29 (d, J = 1 .7 Hz, 6H).
85 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1 H), 8.65 (d, J = 2.1 Hz,
1 H), 8.55 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.84 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.15 (p, J = 6.4 Hz, 1 H), 3.54 (t, J = 6.9 Hz, 2H), 3.24 (dd, J = 8.9, 6.5 Hz, 2H), 2.99 (s, 3H), 2.14 (dq, J = 9.4, 7.0 Hz, 2H), 1 .40 (d, J = 6.4 Hz, 6H).
86 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1 H), 8.70 - 8.55 (m, 2H),
7.99 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.88 (t, J = 7.7 Hz, 2H), 4.42 (d, J = 9.4 Hz, 1 H), 4.16 (td, J = 13.8, 12.7, 7.5 Hz, 2H), 3.69 - 3.43 (m, 2H), 3.18 - 2.92 (m, 2H), 2.31 (d, J = 13.2 Hz, 2H), 2.00 (d, J = 16.6 Hz, 2H), 1 .39 (d, J = 6.4 Hz, 6H).
87 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.49 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.82 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.15 (p, J = 6.4 Hz, 1 H), 3.51 - 3.37 (m, 2H), 3.25 (s, 3H), 1.91 - 1.75 (m, 2H), 1.40 (d, J = 6.4 Hz, 6H), 1.24 (s, 6H).
88 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.1 Hz,
1 H), 8.55 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.83 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.14 (p, J = 6.4 Hz, 1 H), 3.55 - 3.44 (m, 2H), 2.96 (s, 3H), 1.39 (d, J = 6.4 Hz, 6H).
89 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.68 (s, 1 H), 8.57 (d,
J = 2.2 Hz, 1 H), 8.12 (s, 1 H), 8.05 (s, 1 H), 7.82 (d, J = 5.1 Hz, 1 H), 7.78 (d, J = 0.8 Hz, 1 H), 7.18 (d, J = 5.1 Hz, 1 H), 6.29 (tt, J = 55.0, 3.6 Hz, 1 H), 4.67 (td, J = 14.7, 3.6 Hz, 2H), 4.46 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.98 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.52 (ddd, J = 16.0, 14.5, 9.3 Hz, 1 H), 1 .29 (d, J
= 1.7 Hz, 6H).
90 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.57 (d, J = 7.5 Hz, 1 H), 8.53 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.82 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.14 (p, J = 6.4 Hz, 1 H), 3.85 (d, J = 8.1 Hz, 1 H), 1.86 - 1 .66 (m, 6H), 1.53 (dt, J = 13.4, 8.4 Hz, 2H), 1.46 - 1.30 (m, 6H), 1 .23 (s, 3H).
91 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.1 Hz,
1 H), 8.49 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.82 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.15 (p, J = 6.3 Hz, 1 H), 3.55 - 3.43 (m, 2H), 2.21 - 2.02 (m, 4H), 1 .98 - 1.86 (m, 2H), 1.79 (dtd, J = 11.2, 8.6, 4.0 Hz, 1 H), 1.65 - 1.53 (m, 1 H), 1 .45 - 1.35 (m, 6H).
92 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.50 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.83 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.15 (p, J = 6.4 Hz, 1 H), 3.88 (dd,
J = 6.9, 5.8 Hz, 2H), 3.46 (t, J = 6.4 Hz, 2H), 3.06 (s, 3H), 1.40 (d, J = 6.4 Hz, 6H).
93 1 H NMR (400 MHz, Methanol-d4) δ 8.61 - 8.51 (m, 2H), 8.48 (d, J = 2.2 Hz, 1 H),
8.13 (s, 1 H), 7.82 (d, J = 4.9 Hz, 1 H), 7.07 (d, J = 4.9 Hz, 1 H), 4.69 (t, J = 4.9 Hz, 1 H), 4.55 (d, J = 5.2 Hz, 1 H), 4.42 (ddt, J = 49.0, 9.1 , 2.6 Hz, 1 H), 3.97 - 3.74 (m, 2H), 3.54 - 3.38 (m, 1 H), 2.24 (dd, J = 12.6, 7.7 Hz, 1 H), 1.86 - 1 .54 (m, 4H), 1 .39 - 1 .18 (m, 7H).
94 1 H NMR (400 MHz, Methanol-d4) δ 8.59 (s, 1 H), 8.52 (dd, J = 11 .9, 2.3 Hz, 2H),
8.16 (s, 1 H), 7.81 (d, J = 4.9 Hz, 1 H), 7.06 (d, J = 4.9 Hz, 1 H), 4.89 (t, J = 4.8 Hz, 1 H), 4.65 (t, J = 5.3 Hz, 1 H), 4.43 (ddd, J = 48.9, 9.2, 2.3 Hz, 1 H), 4.02 (dt, J = 9.8, 4.3 Hz, 1 H), 3.88 (ddd, J = 35.4, 14.5, 2.3 Hz, 1 H), 3.56 - 3.43 (m, 1 H), 2.53 - 2.38 (m, 1 H), 2.10 - 1.98 (m, 1 H), 1.79 (dt, J = 12.2, 4.0 Hz, 1 H), 1.67 (tt, J = 9.5, 4.3 Hz, 2H), 1 .29 (d, J = 1 .7 Hz, 7H).
95 1 H NMR (400 MHz, Methanol-d4) δ 8.43 (s, 1 H), 8.40 - 8.33 (m, 2H), 8.02 (s, 1 H),
7.75 (d, J = 4.9 Hz, 1 H), 7.02 (d, J = 4.9 Hz, 1 H), 3.89 - 3.63 (m, 5H), 3.54 - 3.44 (m, 2H), 1.85 - 1.76 (m, 2H), 1.75 - 1.54 (m, 4H), 1 .33 (d, J = 6.3 Hz, 6H).
96 1 H NMR (400 MHz, Methanol-d4) δ 8.56 - 8.48 (m, 2H), 8.44 (d, J = 2.2 Hz, 1 H),
8.08 (s, 1 H), 7.76 (d, J = 4.8 Hz, 1 H), 7.04 (d, J = 4.8 Hz, 1 H), 4.78 (s, 2H), 4.65 (s, 2H), 4.27 (p, J = 8.2 Hz, 1 H), 3.84 (p, J = 6.4 Hz, 1 H), 2.70 (ddt, J = 9.7, 7.8, 2.4 Hz, 2H), 2.34 - 2.26 (m, 2H), 1.32 (d, J = 6.3 Hz, 7H). compound 1 H-NMR
97 1 H NMR (400 MHz, Methanol-d4) δ 8.53 (s, 1 H), 8.48 (d, J = 2.2 Hz, 1 H), 8.43 (d,
J = 2.3 Hz, 1 H), 8.10 (s, 1 H), 7.77 (d, J = 4.9 Hz, 1 H), 7.04 (d, J = 4.8 Hz, 1 H), 4.43 (ddd, J = 48.9, 9.0, 2.3 Hz, 1 H), 3.89 (ddd, J = 35.3, 14.5, 2.3 Hz, 1 H), 3.56 - 3.37 (m, 3H), 1.28 (d, J = 1.6 Hz, 6H), 0.86 - 0.68 (m, 4H).
98 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.64 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.72 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.80 - 4.77 (m, 1 H), 4.55 - 4.27 (m, 3H), 4.12 - 3.85 (m, 3H), 3.61 - 3.39 (m, 1 H), 3.03 (s, 3H), 1 .29 (d, J = 1.6 Hz, 6H).
99 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.1 Hz,
1 H), 8.55 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.68 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.22 (p, J = 7.6 Hz, 1 H), 3.92 (ddd, J = 36.4, 14.5, 2.1 Hz, 1 H), 3.48 (ddd, J = 16.1 , 14.5, 9.3 Hz, 1 H), 2.72 (ddt, J = 9.4, 7.5, 2.4 Hz, 2H), 2.26 - 2.11 (m, 2H), 2.1 1 - 1.99 (m, 4H), 1.99 - 1 .82 (m, 2H), 1 .28 (d, J = 1 .7 Hz, 6H).
100 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.86 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.4, 2.2 Hz, 1 H), 3.93 (ddd, J = 36.4, 14.5, 2.1 Hz, 1 H), 3.72 (s, 4H), 3.55 - 3.44 (m, 1 H), 3.42 (s, 3H), 1.29 (d, J = 1.7 Hz, 6H).
101 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 3.92 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.74 (dd, J = 7.9, 3.2 Hz, 1 H), 3.58 - 3.41 (m, 1 H), 2.44 (t, J = 5.0 Hz, 2H), 2.15 - 2.00 (m, 1 H), 1.80 - 1.21 (m, 13H).
102 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.97 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.4, 2.2 Hz, 1 H), 4.10 (t, J = 6.5 Hz, 2H), 4.02 - 3.84 (m, 1 H), 3.61 (t, J = 6.5 Hz, 2H), 3.48 (ddd, J = 16.2, 14.5, 9.4 Hz, 1 H), 3.09 (s, 3H), 1.28 (d, J = 1.7 Hz, 6H).
103 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.03 (d, J = 5.0 Hz, 1 H), 7.90 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.43 (ddd, J = 48.9, 9.3, 2.2 Hz, 1 H), 4.05 - 3.83 (m, 1 H), 3.83 - 3.69 (m, 2H), 3.49 (ddd, J = 16.2, 14.5, 9.3 Hz, 1 H), 3.04 (s, 3H), 2.27 (p, J = 7.3 Hz, 2H), 1.29 (d, J = 1 .7 Hz, 6H).
104 1 H NMR (400 MHz, DMS0-d6) δ 9.06 (s, 1 H), 8.96 (s, 1 H), 8.86 (d, J = 2.3 Hz,
1 H), 8.60 (s, 1 H), 8.04 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.76 (s, 1 H), 7.51 (s, 1 H), 7.21 (d, J = 4.9 Hz, 1 H), 4.84 (s, 1 H), 4.51 (s, 2H), 4.33 (dd, J = 49.3, 9.2 Hz, 1 H), 3.79 (s, 4H), 1 .15 (d, J = 5.0 Hz, 7H).
105 1 H NMR (400 MHz, DMS0-d6) δ 8.88 (s, 2H), 8.74 (s, 1 H), 8.70 (s, 1 H), 7.97 (s,
1 H), 7.85 (S, 1 H), 7.72 (s, 1 H), 7.12 (s, 1 H), 4.85 (s, 1 H), 4.66 (s, 2H), 4.42 (d, J = 9.3 Hz, 1 H), 4.29 (d, J = 9.1 Hz, 1 H), 1 .16 (d, J = 4.3 Hz, 8H).
106 1 H NMR (400 MHz, DMSO-d6) δ 8.82 (d, J = 2.3 Hz, 1 H), 8.72 (d, J = 2.3 Hz, 1 H),
8.72 - 8.60 (m, 2H), 8.12 (s, 1 H), 7.84 (s, 1 H), 7.81 (d, J = 4.8 Hz, 1 H), 7.09 (d, J = 4.8 Hz, 1 H), 4.82 (s, 1 H), 4.35
(ddd, J = 49.5, 9.1 , 1.5 Hz, 1 H), 3.89 - 3.79 (m, 2H), 3.80 - 3.60 (m, 1 H), 3.46 - 3.29 (m, 2H), 2.33 - 2.03 (m, 3H), 1.86 - 1.74 (m, 1 H), 1.15 (d, J = 4.3 Hz, 6H).
107 1 H NMR (400 MHz, DMSO-d6) δ 9.46 (s, 1 H), 9.1 1 (s, 1 H), 8.96 (d, J = 2.2 Hz,
1 H), 8.74 (d, J = 2.2 Hz, 1 H), 8.63 (s, 1 H), 7.94 (d, J = 5.0 Hz, 1 H), 7.86 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.51 (d, J = 5.6 Hz, 2H), 4.34 (ddd, J = 49.3, 9.5, 2.0 Hz, 1 H), 3.90 - 3.59 (m, 1 H), 3.48 - 3.24 (m, 1 H), 2.41 (s, 3H), 2.22 (s, 3H), 1.15 (d, J = 5.5 Hz, 6H).
108
109 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.68 - 8.57 (m, 1 H),
8.27 (s, 1 H), 7.92 (d, J = 5.0 Hz, 1 H), 7.80 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.57 - 4.30 (m, 2H), 3.93 (d, J = 35.5 Hz, 2H), 3.49 (d, J = 9.9 Hz, 2H), 2.94 - 2.71 (m, 3H), 1.61 (d, J = 6.9 Hz, 2H), 1.29 (s, 4H).
110 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.69 - 8.63 (m, 2H),
8.05 (d, J = 4.8 Hz, 1 H), 7.88 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.91 (t, J = 7.6 Hz, 2H), 4.73 (dd, J = 8.2, 4.4 Hz, 2H), 4.52 - 4.28 (m, 3H), 3.80 - 3.40 (m, 5H), 2.76 (dd, J = 13.9, 7.0 Hz, 2H), 2.24 (s, 2H), 1.29 (d, J = 1.7 Hz, 6H).
111
112 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.71 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.41 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.0 Hz, 1 H), 4.45 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 3.96 (ddd, J = 36.7, 14.5, 2.1 Hz, 1 H), 3.63 (s, 2H), 3.56 - 3.44 (m, 1 H), 3.37 (s, 3H), 1.31 (d, J = 1.7 Hz, 6H), 1 .26 - 1 .19 (m, 2H), 1.12 - 1.05 (m, 2H).
113 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.63 (s, 1 H), 8.03 (d, J = 5.0 Hz, 1 H), 7.89 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.56 - 4.34 (m, 2H), 4.26 (s, 1 H), 4.06 - 3.85 (m, 1 H), 3.58 - 3.42 (m, 2H), 3.38 - compound 1H-NMR
3.35 (m, 1H), 3.21 -3.15 (m, 1H), 2.96 (s, 3H), 2.57-2.42 (m, 1H), 2.04- 1.84 (m, 2H), 1.78 - 1.66 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
114 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.65 (s, 1 H), 8.05 (d, J = 5.0 Hz, 1 H), 7.91 (s, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.43 (dd, J =49.1, 9.1 Hz, 1H), 4.26 - 4.10 (m, 1H), 3.93 (dd, J = 36.2, 14.4 Hz, 1H), 3.75-3.63 (m, 2H), 3.60-3.44 (m, 1H), 2.97 (s, 3H), 2.45 (d, J = 14.6 Hz, 2H), 2.28 (s, 1 H), 2.01 - 1.86 (m, 2H), 1.33 - 1.27 (m, 7H).
115 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.1 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.66 (s, 1 H), 8.05 (d, J = 5.1 Hz, 1 H), 7.92 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.43 (dd, J = 49.0, 9.3 Hz, 1 H), 4.32 - 4.16 (m, 2H), 4.03 - 3.69 (m, 2H), 3.63 - 3.38 (m, 2H), 2.96-2.85 (m, 1H), 2.52-2.34 (m, 2H), 2.19 - 1.80 (m, 2H), 1.29 (d, J = 1.7 Hz, 7H), 1.05 (s, 2H), 1.04 (s, 2H).
116 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.84 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.25-4.10 (m, 1H), 4.03 (t, J = 16.4 Hz, 2H), 1.40 (d, J =6.4 Hz, 6H), 1.34 (t, J = 1.2 Hz, 6H).
117 1 H NMR (400 MHz, Methanol-d4) δ 8.49 (s, 1 H), 8.43 - 8.31 (m, 2H), 7.92 (s, 1 H),
7.76 (d, J = 4.9 Hz, 1 H), 7.01 (d, J = 4.9 Hz, 1 H), 4.40 (ddd, J = 48.5, 8.8, 2.5 Hz, 1H), 4.08 (p, J =7.6 Hz, 1H), 3.88 (ddd, J = 34.2, 14.5, 2.4 Hz, 1H), 3.45 (ddd, J = 17.2, 14.5, 8.8 Hz, 1H), 2.63-2.47 (m, 2H), 2.12-1.96 (m, 2H), 1.95- 1.78 (m, 2H), 1.28 (t, J = 1.9 Hz, 6H).
118 1 H NMR (400 MHz, Methanol-d4) δ 8.53 (d, J = 1.6 Hz, 2H), 8.50 (d, J = 2.3 Hz,
1 H), 8.44 (d, J = 2.2 Hz, 1 H), 7.82 - 7.71 (m, 1 H), 7.05 (d, J = 4.9 Hz, 1 H), 4.41 (ddd, J =48.9, 9.1, 2.3 Hz, 1H), 3.86 (ddd, J = 35.2, 14.5, 2.4 Hz, 1H), 3.46 (ddd, J = 16.6, 14.5, 9.1 Hz, 1H), 1.49 (s, 3H), 1.28 (d, J =1.6 Hz, 6H), 0.86 (dt, J = 7.9, 1.9 Hz, 4H).
119 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.66 (s, 1 H), 8.62 (d,
J =2.2 Hz, 1H), 8.14 (s, 1H), 7.98 (s, 1H), 7.83 (d, J =5.1 Hz, 1H), 7.72 (s, 1H), 7.18 (d, J = 5.0 Hz, 1 H), 4.78 - 4.46 (m, 1 H), 4.43 - 4.30 (m, 2H), 4.06 - 3.90 (m, 1H), 3.82 (t, J =5.0 Hz, 2H), 3.52 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 3.35 (s, 3H), 1.29 (d, J = 1.6 Hz, 6H).
120 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.83 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.14 (p, J = 6.3 Hz, 1H), 4.06 (q, J =8.1 Hz, 1H), 2.49 (ddd, J =9.3, 7.6, 2.9 Hz, 2H), 2.16 (td, J = 9.1, 2.8 Hz, 2H), 1.39 (d, J = 6.3 Hz, 9H).
121 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.84 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.26-4.00 (m, 1H), 3.42-3.33 (m, 2H), 3.23-2.97 (m, 4H), 2.19 (d, J = 13.9 Hz, 2H), 2.08 - 1.91 (m, 1 H), 1.92 - 1.70 (m, 2H), 1.40 (d, J = 6.4 Hz, 6H).
122 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.15 (p, J = 6.4 Hz, 1 H), 3.63 (s, 2H), 3.50 - 3.09 (m, 4H), 2.46 - 2.19 (m, 2H), 1.40 (d, J =6.4 Hz, 6H)
123 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.82-4.66 (m, 1H), 4.16 (h, J = 6.4 Hz, 1H), 3.57 (dd, J = 13.6, 7.8 Hz, 1H), 3.45 - 3.33 (m, 1H), 3.26-3.05 (m, 2H), 2.64 (dq, J = 13.2, 6.3 Hz, 1H), 2.34 (dq, J = 13.5, 8.4 Hz, 1H), 1.40 (d, J =6.4 Hz, 6H).
124 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.85 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.60 - 4.47 (m, 1 H), 4.46 - 4.33 (m, 1 H), 4.23 - 4.05 (m, 1 H), 2.56 - 2.31 (m, 4H), 1.96 (s, 3H), 1.40 (d, J = 6.4 Hz, 6H).
125 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.53 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.84 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.20 - 4.09 (m, 1 H), 3.95 - 3.81 (m, 1 H), 3.76 - 3.60 (m, 1 H), 2.03 (dd, J = 24.4, 12.3 Hz, 5H), 1.61 - 1.44 (m, 3H), 1.44 - 1.32 (m, 7H), 0.89 - 0.81 (m, 2H), 0.77 - 0.67 (m, 2H).
126 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.53 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.84 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.21 -4.10(m, 1 H), 3.93 - 3.81 (m, 1 H), 3.70 - 3.54 (m, 5H), 3.41 -3.34 (m, 4H), 2.03 (dd, J =23.5, 11.8 Hz, 4H), 1.57- 1.36 (m, 10H).
127 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.53 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.83 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.22-4.05 (m, 1 H), 3.93 - 3.84 (m, 1 H), 3.83 - 3.70 (m, 1 H), 2.17 - 1.91 (m, 4H), 1.65 - 1.45 (m, 4H), 1.40 (d, J = 6.4 Hz, 6H).
128 1 H NMR (400 MHz, Methanol-d4) δ 9.63 (s, 1 H), 8.81 (s, 1 H), 8.71 (d, J = 2.2 Hz,
1H), 8.63 (d, J =2.2 Hz, 1H), 8.38 (s, 1H), 7.89 (d, J =5.0 Hz, 1H), 7.19 (d, J =5.0 Hz, 1 H), 4.47 (ddd, J = 49.1 , 9.2, 2.0 Hz, 1 H), 4.30 (t, J = 7.3 Hz, 2H), 4.08 - 3.90 compound 1H-NMR
(m, 1 H), 3.63 - 3.44 (m, 1 H), 1.58 (t, J = 7.3 Hz, 3H), 1.30 (d, J = 1.6 Hz, 6H).
129 1 H NMR (400 MHz, Methanol-d4) δ 8.76 - 8.61 (m, 2H), 8.53 (d, J = 2.2 Hz, 1 H),
7.94 (s, 1H), 7.81 (d, J =5.1 Hz, 1H), 7.63 (s, 1H), 7.14 (d, J =5.1 Hz, 1H), 4.45 (dd, J = 48.4, 7.7 Hz, 1 H), 4.21 (t, J = 6.1 Hz, 2H), 3.97 (dd, J = 36.4, 14.4 Hz, 1 H), 3.71 - 3.40 (m, 1 H), 2.73 (t, J = 6.4 Hz, 2H), 2.11 (d, J = 6.0 Hz, 2H), 1.92 (q, J = 5.9 Hz, 2H), 1.29 (d, J = 1.7 Hz, 6H).
130 1 H NMR (400 MHz, Methanol-d4) δ 8.65 (d, J = 2.2 Hz, 1 H), 8.60 (d, J = 1.1 Hz,
1H), 8.58 (d, J = 2.2 Hz, 1H), 8.08 (s, 1H), 7.91 (d, J =5.0 Hz, 1H), 7.14 (d, J =5.0 Hz, 1H), 4.42 (ddd, J =49.0, 9.2, 2.1 Hz, 1H), 4.19 (dd, J =7.4, 5.8 Hz, 1H), 4.09 - 3.80 (m, 3H), 3.49 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 2.67 (dq, J = 13.4, 7.3 Hz, 1H), 2.08- 1.94 (m, 1H), 1.41 (s, 3H), 1.28 (d, J = 1.7 Hz, 9H), 1.19 (s, 1H).
131 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.1 Hz,
1 H), 8.47 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.80 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.19 - 4.07 (m, 1 H), 2.20 - 2.00 (m, 12H), 1.87 (s, 3H), 1.40 (d, J = 6.4 Hz, 6H).
132 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.85 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.21 - 4.09 (m, 1 H), 2.44 (s, 6H), 1.92 (s, 3H), 1.41 (d, J = 6.4 Hz, 6H).
133 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1 H), 8.51 (s, 1 H), 7.97 (d, J = 5.1 Hz, 1 H), 7.82 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J =49.0, 9.3, 2.2 Hz, 1H), 3.93 (ddd, J =36.2, 14.5, 2.2 Hz, 1H), 3.64 (t, J = 6.6 Hz, 2H), 3.56 (t, J = 5.7 Hz, 2H), 3.53 - 3.41 (m, 1 H), 3.37 (s, 3H), 2.01 (p, J = 6.3 Hz, 2H), 1.28 (d, J = 1.7 Hz, 6H).
134 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.84 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.91 - 4.85 (m, 2H), 4.39 (d, J = 6.1 Hz, 2H), 4.22 - 4.10 (m, 1 H), 3.94 - 3.81 (m, 1H), 3.79-3.67 (m, 2H), 2.13-1.93 (m, 4H), 1.59 (s, 3H), 1.55 - 1.38 (m, 9H).
135 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.84 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.21 -4.09 (m, 1H), 3.90 (s, 1H), 3.67 (s, 1H), 2.14-2.03 (m, 2H), 2.01 - 1.94 (m, 2H), 1.57 - 1.43 (m, 4H), 1.41 (d, J = 6.4 Hz, 6H), 1.36 (s, 6H).
136 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.1 Hz,
1 H), 8.60 (d, J = 3.5 Hz, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.70 (d, J = 1.7 Hz, 1 H), 7.21 (dd, J =5.1, 1.6 Hz, 1H), 4.63-4.30 (m, 2H), 3.93 (ddd, J = 36.4, 14.6, 2.3 Hz, 1H), 3.59-3.39 (m, 1H), 3.10-2.83 (m, 2H), 2.50-2.23 (m, 2H), 1.55 (d, J = 21.9 Hz, 3H), 1.29 (d, J = 1.7 Hz, 6H).
137 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.85 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.43 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 3.94 (ddd, J =36.6, 14.6, 2.1 Hz, 1H), 3.81 - 3.62 (m, 2H), 3.49 (dddd, J = 15.8, 14.6, 9.4, 1.1 Hz, 1H), 2.25 - 2.06 (m, 1H), 1.68 (tdd, J = 12.1, 8.0, 4.8 Hz, 1H), 1.43 (dtd, J = 13.4, 7.7, 3.7
Hz, 1H), 1.29 (d, J = 1.7 Hz, 6H).
138 1 H NMR (400 MHz, Methanol-d4) δ 9.02 (s, 1 H), 8.73 - 8.63 (m, 2H), 8.60 (d, J =
2.2 Hz, 1H), 7.81 (d, J =5.0 Hz, 1H), 7.70 (d, J =2.4 Hz, 1H), 7.14 (d, J =5.0 Hz, 1H), 6.31 (d, J =2.4 Hz, 1H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 4.14 (s, 2H), 3.97 (ddd, J =36.3, 14.6, 2.2 Hz, 1H), 3.52 (ddd, J = 16.1, 14.6, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H), 1.23 (s, 6H).
139 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.1 Hz,
1 H), 8.58 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.85 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.31 -4.20 (m, 1H), 4.15 (p, J = 6.4 Hz, 1H), 3.43-3.30 (m, 2H), 3.13 (d, J = 13.6 Hz, 2H), 2.34 (t, J =8.4 Hz, 2H), 2.22 (q, J = 11.3, 10.6 Hz, 2H), 1.39 (d, J =6.4 Hz, 6H).
140 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 9.6 Hz, 2H), 8.51 (dd, J = 21.6, 2.2
Hz, 2H), 7.96 - 7.68 (m, 3H), 7.61 - 7.37 (m, 2H), 7.06 (d, J = 4.8 Hz, 1 H), 4.45 (ddd, J = 49.0, 9.1 , 2.2 Hz, 1 H), 3.93 (ddd, J = 35.8, 14.5, 2.3 Hz, 1 H), 3.65 - 3.41 (m, 1H), 1.29 (d, J = 1.7 Hz, 6H).
141 1 H NMR (400 MHz, DMSO-d6) δ 8.80 (s, 1 H), 8.72 - 8.57 (m, 2H), 8.46 (d, J = 2.2
Hz, 1 H), 7.91 - 7.74 (m, 2H), 7.74 - 7.39 (m, 4H), 7.05 (d, J = 4.9 Hz, 1 H), 4.37 (ddd, J =49.2, 9.3, 2.2 Hz, 1H), 3.92-3.59 (m, 1H), 3.42 (ddd, J = 16.1, 14.4, 9.2 Hz, 1H), 1.16 (dd, J = 4.2, 1.6 Hz, 6H).
142
143 1 H NMR (400 MHz, Methanol-d4) δ 8.80 (s, 1 H), 8.67 (d, J = 2.2 Hz, 1 H), 8.49 (d,
J =2.2 Hz, 1H), 8.17 (s, 1H), 8.06-7.43 (m, 5H), 7.14 (d, J = 5.0 Hz, 1H), 4.48 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 4.00 (ddd, J = 36.5, 14.5, 2.1 Hz, 1H), 3.53 (ddd, J = 15.9, 14.5,9.4 Hz, 1H), 1.52-1.11 (m, 6H).
144 1H NMR (400 MHz, DMS0-d6) δ 10.06 (s, 1H), 9.02 (s, 1H), 8.89 (d, J =2.2 Hz,
1H), 8.72 (s, 1H), 8.41 (s, 1H), 7.99 (d, J =4.9 Hz, 1H), 7.30 (d, J = 12.6 Hz, 1H), 7.14 (d, J = 4.9 Hz, 1H), 4.87 (d, J =4.8 Hz, 1H), 4.84-4.50 (m, 2H), 4.08 (dd, J = 36.6, 14.1 Hz, 1H), 3.72 (s,4H), 3.53 (s,4H), 1.18 (s,6H). compound 1H-NMR
145 1H NMR (400 MHz, DMSO-d6) δ 11.55 (s, 1H), 10.12 (s, 1H), 9.12 (s, 1H), 8.94 (s,
1 H), 8.89 - 8.81 (m, 2H), 8.51 (d, J = 2.8 Hz, 1 H), 8.48 (s, 1 H), 8.23 (d, J = 2.4 Hz, 1H), 7.90 (d, J =4.8 Hz, 1H), 7.12 (d, J =4.8 Hz, 1H), 4.40 (m, 1H), 3.77 (m, 1H), 1.17 (d, J = 6.0 Hz, 6H).
146 1H NMR (400 MHz, DMSO-d6) δ 12.06 (s, 1H), 9.42 (d, J =22.2 Hz, 1H), 9.19 (s,
1 H), 8.97 (s, 1 H), 8.87 (d, J = 2.3 Hz, 1 H), 8.80 (s, 1 H), 7.89 (d, J = 4.8 Hz, 1 H), 7.13 (d, J = 4.7 Hz, 1H), 2.69 (s, 3H), 1.17 (d, J =6.3 Hz, 6H), 1.12 (d, J = 1.8 Hz, 3H).
147 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.69 (dd, J = 2.2, 0.4
Hz, 1 H), 8.58 (s, 1 H), 8.24 (s, 1 H), 7.95 (dd, J = 5.1 , 0.5 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1H), 4.42 (ddd, J =49.0, 9.4, 2.2 Hz, 1H), 4.17 (d, J =8.7 Hz, 2H), 3.99-3.78 (m, 3H), 3.48 (ddd, J = 16.2, 14.6, 9.3 Hz, 1H), 2.67 (t, J =2.4 Hz, 1H), 2.13 (q, J = 2.1 , 1.6 Hz, 2H), 1.28 (d, J = 1.7 Hz, 6H).
148 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (dd, J = 2.2, 0.4
Hz, 1H), 8.60 (s, 1H), 8.16 (s, 1H), 7.99 (dd, J = 5.1, 0.5 Hz, 1H), 7.21 (d, J =5.1 Hz, 1H), 4.41 (ddd, J =49.0, 9.4, 2.2 Hz, 1H), 4.15-3.77 (m, 5H), 3.47 (ddd, J = 16.1, 14.5, 9.4 Hz, 1H), 3.20 (t, J = 6.8 Hz, 1H), 2.33 (ddd, J =6.8, 2.0, 1.1 Hz, 2H), 1.28 (d, J = 1.6 Hz, 6H).
149 1 H NMR (400 MHz, DMSO-d6) δ 7.93 (d, J = 2.2 Hz, 1 H), 7.84 (dd, J = 2.2, 0.4 Hz,
1H), 7.73 (s, 1H), 7.17 (dd, J =5.1, 0.5 Hz, 1H), 7.01 (s, 1H), 6.39 (d, J =5.0 Hz, 1 H), 3.56 (p, J = 8.3 Hz, 1 H), 3.43 - 3.21 (m, 2H), 1.75 - 1.60 (m, 2H), 1.60 - 1.40 (m, 2H), 1.38- 1.24 (m, 2H), 1.16 (ddd, J = 14.5, 11.1, 7.7 Hz, 2H), 0.58 (d, J =6.4 Hz, 6H).
150 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (dd, J = 2.2, 0.5
Hz, 1 H), 8.61 (s, 1 H), 8.02 (dd, J = 5.1 , 0.5 Hz, 1 H), 7.97 (s, 1 H), 7.21 (dd, J = 5.1 , 0.4 Hz, 1H), 4.70-4.52 (m, 1H), 4.52-4.29 (m, 2H), 4.14 (dt, J = 10.6, 5.0 Hz, 1H), 4.04-3.84 (m, 2H), 3.67-3.43 (m, 3H), 2.32-2.13 (m, 1H), 1.94 - 1.75 (m, 1H), 1.29 (d, J = 1.7 Hz, 6H).
151 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.06 - 8.00 (m, 1 H), 7.97 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.73 - 4.52 (m, 1H), 4.51 -4.29 (m, 2H), 4.14 (dt, J = 10.7, 5.1 Hz, 1H), 4.07-3.86 (m, 2H), 3.74-3.41 (m, 3H), 2.30-2.14 (m, 1H), 1.93 - 1.78 (m, 1H), 1.29 (d, J = 1.7 Hz, 6H).
152 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (dd, J = 2.2, 0.4
Hz, 1 H), 8.57 (s, 1 H), 7.99 (dd, J = 5.0, 0.5 Hz, 1 H), 7.84 (s, 1 H), 7.21 (d, J = 5.2 Hz, 1H), 4.59-4.43 (m, 1H), 4.22-4.08 (m, 1H), 3.25-3.18 (m, 2H), 3.15-3.07 (m, 2H), 2.66 (ddd, J = 9.3, 7.7, 2.8 Hz, 2H), 2.47 - 2.36 (m, 2H), 1.40 (d, J = 6.4 Hz, 6H).
153 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1 H), 8.69 - 8.59 (m, 1 H),
8.54 (s, 1 H), 8.04 - 7.91 (m, 1 H), 7.82 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.36 (p, J = 8.2 Hz, 1 H), 4.13 (p, J = 6.4 Hz, 1 H), 2.52 (ddd, J = 11.8, 7.4, 5.0 Hz, 1 H), 2.47 - 2.37 (m, 1 H), 2.31 - 1.97 (m, 6H), 1.39 (d, J = 6.4 Hz, 6H), 1.31 (s, 3H).
154 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.86 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J =49.1, 9.3, 2.1 Hz, 1H), 4.02-3.74 (m, 2H), 3.48 (td, J = 15.3, 9.8 Hz, 1H), 2.04- 1.89 (m, 2H), 1.91 -1.71 (m, 4H), 1.66 (td, J = 13.3, 4.0 Hz, 2H), 1.31 - 1.23 (m, 9H).
155 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.62 (d, J = 0.8 Hz, 1 H), 8.04 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.52 - 4.31 (m, 2H), 4.04 - 3.82 (m, 1 H), 3.65 - 3.42 (m, 3H), 3.02 (s, 3H), 2.93 (dd, J = 17.1, 5.3 Hz, 1H), 2.54 (dd, J = 17.1, 8.4 Hz, 1H), 2.39-2.28 (m, 1H), 2.19-2.04 (m, 1H), 1.29 (d, J = 1.7 Hz, 6H).
156 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.06 (d, J = 5.1 Hz, 1 H), 7.92 (d, J = 1.3 Hz, 2H), 7.61 (t, J = 1.7 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 6.67 (dd, J = 1.9, 0.9 Hz, 1 H), 4.43 (ddd, J = 49.2, 9.3, 2.1 Hz, 1 H), 4.31 - 4.15 (m, 2H), 4.03 - 3.84 (m, 1 H), 3.58 - 3.39 (m, 2H), 2.21 (d, J = 12.8 Hz, 2H), 1.81 - 1.63 (m, 2H), 1.29 (d, J = 1.7 Hz, 6H).
157 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (dd, J = 3.2, 2.2 Hz, 1 H), 8.68 - 8.50 (m,
2H), 7.99 (dd, J = 7.8, 5.0 Hz, 1 H), 7.85 (d, J = 9.0 Hz, 1 H), 7.69 - 7.36 (m, 1 H), 7.21 (dd, J = 5.1 , 4.0 Hz, 1 H), 6.60 - 6.36 (m, 2H), 4.52 - 4.27 (m, 2H), 4.27 - 4.07 (m, 1 H), 1.40 (dd, J = 6.4, 1.7 Hz, 6H).
158 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (dd, J = 7.7, 2.1 Hz, 2H), 8.55 (s, 1 H),
8.32 (s, 1 H), 7.94 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.40 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1H), 4.42-4.23 (m, 2H), 3.98-3.80 (m, 2H), 3.74 (d, J = 10.6 Hz, 1H), 3.47 (ddd, J = 16.0, 14.5, 9.4 Hz, 1H), 3.26 (s, 3H), 2.20-2.03 (m, 12H), 1.48 (s, 3H), 1.28 (d, J = 1.7 Hz, 6H).
159 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.70 (m, 2H), 8.54 (s, 1 H), 8.31 (s, 1 H),
7.94 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.51 - 4.26 (m, 3H), 3.99 - 3.79 (m, 3H), 3.47 (ddd, J = 16.0, 14.5, 9.4 Hz, 1H), 2.22-2.04 (m, 12H), 1.47 (s, 3H), compound 1H-NMR
1.28 (d, J = 1.7 Hz, 6H).
160 1 H NMR (400 MHz, Methanol-d4) δ 8.99 (s, 1 H), 8.69 (d, J = 2.2 Hz, 1 H), 8.63 (d,
J = 2.2 Hz, 1H), 8.26 (s, 1H), 8.01 (d, J =5.0 Hz, 1H), 7.17 (d, J = 5.0 Hz, 1H), 5.29 (tt, J = 6.8, 3.5 Hz, 1H), 4.57-4.36 (m, 2H), 4.05 (ddd, J =33.0, 14.5, 2.9 Hz, 1 H), 3.58 (ddd, J = 16.7, 14.5, 8.7 Hz, 1 H), 2.83 - 2.64 (m, 4H), 2.50 (tt, J = 7.0, 3.6 Hz, 1 H), 1.30 (t, J = 2.1 Hz, 6H), 0.72 (td, J = 6.9, 4.8 Hz, 2H), 0.53 - 0.43 (m, 2H).
161 1 H NMR (400 MHz, Methanol-d4) δ 8.99 (s, 1 H), 8.69 (d, J = 2.2 Hz, 1 H), 8.63 (d,
J =2.2 Hz, 1H), 8.22 (s, 1H), 8.01 (d, J =5.0 Hz, 1H), 7.17 (d, J = 5.0 Hz, 1H), 5.30 (tt, J = 6.7, 3.8 Hz, 1H), 4.59-4.35 (m, 2H), 4.05 (ddd, J =33.1, 14.5, 2.9 Hz, 1 H), 3.58 (ddd, J = 16.7, 14.5, 8.8 Hz, 1 H), 2.93 (s, 6H), 2.83 - 2.67 (m, 4H), 1.35 - 1.26 (m, 6H).
162 1 H NMR (400 MHz, Methanol-d4) δ 8.98 (s, 1 H), 8.69 (d, J = 2.2 Hz, 1 H), 8.64 (d,
J =2.2 Hz, 1H), 8.23 (s, 1H), 8.02 (d, J =5.0 Hz, 1H), 7.17 (d, J = 5.0 Hz, 1H), 5.29 (tt, J = 6.9, 3.7 Hz, 1 H), 4.52 (dd, J = 8.8, 2.8 Hz, 1 H), 4.41 (td, J = 8.9, 8.1 , 2.4 Hz, 1H), 4.05 (ddd, J = 33.0, 14.5, 2.9 Hz, 1H), 3.58 (ddd, J = 16.7, 14.5, 8.7 Hz, 1H), 2.77 (ddt, J = 11.9, 8.0, 3.5 Hz, 1H), 2.72 (s, 3H), 2.65 (dt, J = 14.0, 6.4 Hz, 2H), 1.30 (dd, J = 2.9, 1.7 Hz, 6H).
163 1 H NMR (400 MHz, Methanol-d4) δ 9.00 (s, 1 H), 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d,
J =2.2 Hz, 1H), 8.44 (s, 1H), 8.14-8.09 (m, 1H), 7.21 (d, J = 5.1 Hz, 1H), 6.99- 6.84 (m, 1H), 4.99 (dt, J = 10.4,
5.9 Hz, 1 H), 4.43 (ddd, J = 48.6, 8.8, 2.8 Hz, 1 H), 4.04 (ddd, J = 33.4, 14.5, 2.8 Hz, 1 H), 3.72 - 3.62 (m, OH), 3.61 - 3.49 (m, 1 H), 2.48 (tt, J = 7.0, 3.6 Hz, 1 H), 2.35 (d, J = 12.0 Hz, 2H), 2.10 (d
, J = 12.6 Hz, 2H), 1.85 (q, J = 12.1 Hz, 2H), 1.55 (q, J = 11.1 Hz, 2H), 1.30 (dd, J = 3.5, 1.6 Hz, 6H), 0.70 (td, J = 6.9, 4.8 Hz, 2H), 0.51 - 0.42 (m, 2H).
164 1 H NMR (400 MHz, Methanol-d4) δ 9.01 (s, 1 H), 8.75 (d, J = 2.2 Hz, 1 H), 8.65 (d,
J =2.2 Hz, 1H), 8.47 (s, 1H), 8.10 (d, J =4.8 Hz, 1H), 7.21 (d, J = 5.1 Hz, 1H), 4.96 (dq, J = 10.6, 6.0, 5.1 Hz, 1H), 4.43 (ddd, J =48.6, 8.8, 2.8 Hz, 1H), 4.04 (ddd, J = 33.2, 14.5, 2.8 Hz, 1 H), 3.68 (tt, J = 11.3, 3.9 Hz, 1 H), 3.62 - 3.49 (m, 1H), 2.91 (s, 6H), 2.45-2.31 (m, 2H), 2.09 (dd, J = 13.4, 3.7 Hz, 2H), 1.83 (q, J = 12.0 Hz, 2H), 1.69-1.51 (m, 2H), 1.29 (dd, J =3.6, 1.6 Hz, 6H).
165 1 H NMR (400 MHz, Methanol-d4) δ 9.00 (s, 1 H), 8.76 (d, J = 2.2 Hz, 1 H), 8.67 (d,
J =2.2 Hz, 1H), 8.42 (s, 1H), 8.13 (d, J =5.1 Hz, 1H), 7.22 (d, J = 5.0 Hz, 1H), 5.00 (dt, J = 10.3, 6.0 Hz, 1H), 4.43 (ddd, J =48.6, 8.8, 2.8 Hz, 1H), 4.04 (ddd, J = 33.5, 14.5, 2.8 Hz, 1H), 3.70-3.50 (m, 1H), 2.70 (s, 3H), 2.34 (d, J = 12.6 Hz, 2H), 2.10 (d, J = 13.0 Hz, 2H), 1.85 (q, J = 11.7 Hz, 2H), 1.51 (q, J = 10.7 Hz, 2H), 1.30 (dd, J = 3.5, 1.6 Hz, 6H).
166 1 H NMR (400 MHz, Methanol-d4) δ 8.95 (s, 1 H), 8.74 (d, J = 2.2 Hz, 1 H), 8.68 (d,
J =2.2 Hz, 1H), 8.43 (s, 1H), 8.17-8.07 (m, 1H), 7.21 (d, J = 5.1 Hz, 1H), 5.21 (s, 1 H), 4.46 (ddd, J = 49.1 , 9.3, 2.3 Hz, 1 H), 4.08 (ddd, J = 36.4, 14.6, 2.4 Hz, 1 H), 3.79 - 3.65 (m, 1 H), 3.61 - 3.49 (m, 1 H), 2.47 (tt, J = 7.0, 3.6 Hz, 1 H), 2.23 (d, J = 14.0 Hz, 2H), 2.05- 1.82 (m, 4H), 1.67 (q, J = 11.4, 10.5 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H), 0.70 (td, J = 6.9, 4.8 Hz, 2H), 0.49 - 0.40 (m, 2H).
167 1 H NMR (400 MHz, Methanol-d4) δ 8.96 (s, 1 H), 8.73 (d, J = 2.2 Hz, 1 H), 8.67 (d,
J =2.2 Hz, 1H), 8.43 (s, 1H), 8.10 (d, J =5.0 Hz, 1H), 7.20 (d, J = 5.0 Hz, 1H), 5.22 (s, 1H), 4.48 (ddd, J =48.9, 9.2, 2.4 Hz, 1H), 4.10 (ddd, J =36.1, 14.5, 2.4 Hz, 1 H), 3.72 (t, J = 11.0 Hz, 1 H), 3.63 - 3.50 (m, 1 H), 2.90 (s, 6H), 2.36 - 2.24 (m, 2H), 1.95 (d, J = 13.7 Hz, 1H), 1.87 (d, J = 16.2 Hz, 3H), 1.77 - 1.60 (m, 2H), 1.29 (s, 6H).
168 1 H NMR (400 MHz, Methanol-d4) δ 8.94 (s, 1 H), 8.74 (d, J = 2.2 Hz, 1 H), 8.67 (d,
J =2.2 Hz, 1H), 8.43 (s, 1H), 8.10 (d, J =5.0 Hz, 1H), 7.20 (d, J = 5.1 Hz, 1H), 5.20 (s, 1H), 4.46 (ddd, J =49.0, 9.3, 2.4 Hz, 1H), 4.07 (ddd, J =36.2, 14.5, 2.4 Hz, 1H), 3.67 (t, J = 10.1 Hz, 1H), 3.61 - 3.45 (m, 1H), 2.70 (s, 3H), 2.22 (d, J = 14.1 Hz, 2H), 1.96 (t, J = 13.3 Hz, 2H), 1.87 (dd, J = 13.1, 4.3 Hz, 2H), 1.66 (d, J = 15.7 Hz, 2H), 1.30 (s, 6H).
169 1 H NMR (400 MHz, Methanol-d4) δ 8.96 (d, J = 0.8 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1H), 8.54 (d, J =2.2 Hz, 1H), 8.34 (s, 1H), 7.97 (d, J =4.9 Hz, 1H), 7.14 (d, J =4.9 Hz, 1 H), 5.39 - 5.29 (m, 1 H), 4.51 (dd, J = 8.8, 2.7 Hz, 1 H), 4.39 (dd, J = 8.8, 2.7 Hz, 1H), 4.18-3.97 (m, 2H), 3.62-3.46 (m, 1H), 2.97-2.80 (m, 4H), 1.30 (t, J = 1.6 Hz, 6H).
170 1 H NMR (400 MHz, Methanol-d4) δ 8.87 (d, J = 2.1 Hz, 1 H), 8.74 (d, J = 2.1 Hz,
1 H), 8.68 (d, J = 4.4 Hz, 1 H), 8.63 (s, 1 H), 8.62 (d, J = 2.1 Hz, 1 H), 8.34 (dt, J = 8.2, 1.8 Hz, 1H), 7.93 (d, J = 5.1 Hz, 1H), 7.91 (s, 1H), 7.84-7.78 (m, 1H), 7.18 (d, J = 5.1 Hz, 1 H), 4.98 (s, 2H), 4.45 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 3.96 (ddd, J = 36.5, 14.5, 2.1 Hz, 1H), 3.52 (ddd, J = 16.1, 14.5, 9.4 Hz, 1H), 1.29 (d, J = 1.7 Hz, 6H).
171 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (d, J = 2.2 Hz, 1 H), 8.63 (ddd, J = 5.0,
1.8, 0.9 Hz, 1 H), 8.60 (d, J = 0.8 Hz, 2H), 8.60 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), compound 1H-NMR
7.95 - 7.90 (m, 1 H), 7.87 (s, 1 H), 7.59 (dt, J = 7.9, 1.0 Hz, 1 H), 7.42 (ddd, J = 7.6, 5.0, 1.1 Hz, 1 H), 7.19 (d, J = 5.1 Hz, 1 H), 4.45 (ddd, J = 49.0, 9.4, 2.2 Hz, 1 H),
3.96 (ddd, J =36.5, 14.5, 2.2 Hz, 1H), 3.51 (ddd, J = 16.0, 14.5, 9.4 Hz, 1H), 1.29 (d, J = 1.6 Hz, 7H).
172 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 1 H), 8.70 (d, J = 2.2 Hz, 1 H), 8.66 (d,
J = 2.7 Hz, 1H), 8.58 (d, J =2.2 Hz, 1H), 8.57 (d, J = 2.4 Hz, 1H), 8.17-8.07 (m, 3H), 7.85 (d, J =5.1 Hz, 1H), 7.83 (s, 1H), 7.15 (d, J =5.1 Hz, 1H), 6.60 (t, J = 2.2 Hz, 1H), 4.56-4.39 (m, 1H), 4.08-3.93 (m, 1H), 3.54 (td, J = 15.4, 9.4 Hz, 1H), 1.30 (d, J = 1.7 Hz, 6H).
173 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.03 (d, J = 5.0 Hz, 1 H), 7.92 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.41 (dd, J = 50.0, 8.7 Hz, 1 H), 4.00 - 3.81 (m, 2H), 3.73 - 3.57 (m, 9H), 3.48 (td, J = 15.6, 9.4 Hz, 1H), 2.84-2.71 (m, 2H), 2.29-2.18 (m, 5H), 1.92 (d, J = 13.2 Hz, 2H), 1.77 (q, J = 12.7 Hz, 2H), 1.55 (q, J = 12.5, 12.1 Hz, 2H), 1.28 (d, J = 1.6 Hz, 6H).
174 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.1 Hz,
1 H), 8.56 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.66 (t, J = 11.5 Hz, 2H), 4.47 (d,
J =8.9 Hz, 1H), 4.33 (t, J = 12.4 Hz, 3H), 3.92 (dd, J =34.8, 15.2 Hz, 2H), 3.48 (td, J = 15.5, 9.4 Hz, 1H), 2.44 (t, J = 11.9 Hz, 1H), 2.24 (d, J = 12.6 Hz, 2H), 1.96 (d, J = 13.6 Hz, 2H), 1.73 (q,
J = 12.8, 12.4 Hz, 2H), 1.52 (d, J = 12.2 Hz, 1H), 1.28 (d, J = 1.6 Hz, 6H).
175
176 1 H NMR (400 MHz, Methanol-d4) δ 8.94 (s, 1 H), 8.76 (s, 1 H), 8.64 (s, 1 H), 8.54 (s,
1 H), 8.50 (s, 1 H), 8.33 (d, J = 9.0 Hz, 2H), 7.84 (d, J = 5.0 Hz, 1 H), 7.72 (d, J = 8.7 Hz, 2H), 7.13 (d, J = 5.0 Hz, 1H), 4.47 (dd, J =47.8, 8.5 Hz, 1H), 3.98 (dd, J = 36.4, 14.0 Hz, 1H), 3.66- 3.44 (m, 2H), 1.35- 1.26 (m, 6H).
177 1 H NMR (400 MHz, Methanol-d4) δ 8.71 - 8.69 (m, 2H), 8.59 (d, J = 2.2 Hz, 1 H),
8.28 (s, 1 H), 8.03 - 7.96 (m, 2H), 7.79 (d, J = 5.1 Hz, 1 H), 7.73 (d, J = 2.3 Hz, 1 H), 7.57-7.51 (m, 2H), 7.15 (d, J =
5.1 Hz, 1H), 6.77 (d, J =2.3 Hz, 1H), 4.57-4.39 (m, 1H), 4.00 (dd, J = 36.6, 14.7 Hz, 1H), 3.53 (td, J = 15.4, 9.4 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
178 1 H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 2.2 Hz, 2H), 8.56 (d, J = 2.2 Hz,
1H), 8.18 (s, 1H), 8.06 (s, 2H), 7.84-7.79 (m, 2H), 7.77 (d, J = 5.1 Hz, 1H), 7.50 - 7.44 (m, 2H), 7.15 (d, J = 5.1 Hz, 1H), 4.47 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1H), 4.07- 3.92 (m, 1H), 3.53 (td, J = 15.4, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
179 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (s, 1 H), 8.70 (d, J = 2.2 Hz, 1 H), 8.58 (d,
J =2.1 Hz, 1H), 8.50 (s, 1H), 8.34 (s, 1H), 8.25-8.18 (m, 2H), 7.81 (d, J =5.1 Hz, 1H), 7.62-7.55 (m, 2H), 7.16 (d, J =5.1 Hz, 1H), 4.47 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 4.12-3.88 (m, 4H), 3.53 (ddd, J = 16.3, 14.8, 9.4 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
180 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (s, 1 H), 8.68 (d, J = 2.2 Hz, 1 H), 8.63 (d,
J = 1.2 Hz, 1H), 8.59 (d, J =2.2 Hz, 1H), 8.36 (s, 1H), 8.12-8.05 (m, 2H), 7.95 (d, J = 1.2 Hz, 1H), 7.83 (d, J =5.1 Hz, 1H), 7.75-7.67 (m, 2H), 7.15 (d, J =5.1 Hz, 1 H), 4.48 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.00 (ddd, J = 36.3, 14.5, 2.1 Hz, 1 H), 3.54 (ddd, J = 16.2, 14.6, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
181 1 H NMR (400 MHz, Methanol-d4) δ 9.11 (s, 1 H), 8.78 (d, J = 0.6 Hz, 1 H), 8.62 (d,
J = 2.2 Hz, 1 H), 8.51 (d, J = 2.2 Hz, 1 H), 8.33 (d, J = 0.8 Hz, 1 H), 8.00 (d, J = 4.9 Hz, 1H), 7.89 (s, 1H), 7.13 (d, J = 4.8 Hz, 1H), 4.44 (ddd, J =48.9, 9.4, 2.2 Hz, 1H), 4.15 (s, 2H), 3.87 (ddd, J = 36.5, 14.6, 2.2 Hz, 1H), 3.60-3.42 (m, 1H), 1.28 (d, J = 1.6 Hz, 6H).
182 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.91 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.05 - 3.78 (m, 2H), 3.58 - 3.39 (m, 1 H), 2.73 (s, 3H), 2.36-2.17 (m, 3H), 1.95 (d, J = 13.6 Hz, 2H), 1.82- 1.68 (m, 2H), 1.58- 1.41 (m, 2H), 1.28 (d, J = 1.6 Hz, 6H).
183 1H NMR (400 MHz, DMS0-d6) δ 11.19 (m, 1H), 9.21 -9.04 (m, 3H), 8.95 (s, 1H),
8.89 (d, J = 2.2 Hz, 1 H), 8.84 - 8.73 (m, 2H), 7.90 (d, J = 4.8 Hz, 1 H), 7.73 (s, 1 H), 7.16 (d, J = 4.8 Hz, 1H), 4.31 (dd, J =48.9, 9.2 Hz, 1H), 3.68-3.82 (m, 1H), 3.35 (t, J = 11.9 Hz, 1H), 1.18 - 1.10 (m, 6H).
184 1H NMR (400 MHz, DMS0-d6) δ 10.73 (s, 1H), 9.13 (s, 1H), 8.88 (d, J =2.2 Hz,
1 H), 8.84 (s, 1 H), 8.66 (d, J = 2.4 Hz, 1 H), 8.42 (s, 1 H), 8.11 (s, 1 H), 7.88 (d, J = 4.8 Hz, 1H), 7.67 (d, J =8.5 Hz, 1H), 7.14 (d, J =4.9 Hz, 1H), 4.38 (dd, J = 49.5, 9.4 Hz, 1H), 3.87-3.67 (m, 1H), 3.52-3.35 (m, 1H), 3.15 (s, 1H), 2.60 (s, 3H), 1.22 - 1.12 (m,6H).
185 1H NMR (400 MHz, DMS0-d6) δ 11.58 (s, 1H), 10.12 (s, 1H), 9.17-9.09 (m, 1H),
8.93 (s, 1 H), 8.87 - 8.79 (m, 2H), 8.51 (dd, J = 11.7, 2.0 Hz, 2H), 8.24 (d, J = 2.7 Hz, 1H), 7.91 (d, J = 4.8 Hz, 1H), 7.13 (d, J = 4.8 Hz, 1H), 4.41 (dd, J =49.7, 9.2 Hz, 1H), 1.17 (dd, J = 6.2, 1.6 Hz, 7H). compound 1H-NMR
186 1H NMR (400 MHz, DMSO-d6) δ 10.87 (s, 1H), 9.21 -9.04 (m, 1H), 8.91 -8.83(m,
2H), 8.74 (dd, J =5.2, 2.4 Hz, 2H), 8.61 (s, 1H), 8.21 -8.12 (m, 1H), 8.07 (d, J = 8.6 Hz, 1H), 7.88 (d, J =4.9 Hz, 1H), 7.13 (d, J =4.9 Hz, 1H), 4.38 (dd, J = 49.3, 9.3 Hz, 1H), 3.78 (dd, J =37.8, 10.6 Hz, 1H), 3.53-3.34 (m, 1H), 1.16 (dd, J =5.6, 1.6 Hz, 6H).
187 1H NMR (400 MHz, DMSO-d6) δ 10.65 (s, 1H), 9.12 (s, 1H), 8.87 (d, J =2.3 Hz,
1 H), 8.81 (s, 1 H), 8.59 (d, J = 2.2 Hz, 1 H), 8.29 (s, 1 H), 8.08 (s, 1 H), 7.97 (d, J = 8.4 Hz, 1H), 7.90 (d, J =4.9 Hz, 1H), 7.13 (d, J =4.9 Hz, 1H), 4.38 (dd, J = 49.7, 9.0 Hz, 1 H), 3.78 (dd, J = 36.5, 15.0 Hz, 1 H), 3.50 - 3.32 (m, 1 H), 2.32 (s, 3H), 1.17 (dd, J =5.5, 1.6 Hz, 7H).
188 1 H NMR (400 MHz, DMS0-d6) δ 9.46 (s, 1 H), 8.97 (d, J = 2.2 Hz, 1 H), 8.82 (d, J =
2.2 Hz, 1 H), 8.76 (d, J = 6.9 Hz, 1 H), 8.61 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.85 (s, 1H), 7.21 (d, J =4.9 Hz, 1H),
4.40 (q, J = 7.3 Hz, 1H), 4.22 (s, 1H), 4.03 (d, J =5.7 Hz, 1H), 2.13 -1.99 (m, 1H), 1.89 (dt, J = 18.4, 7.4 Hz, 2H), 1.68 (dt, J = 13.2, 6.6 Hz, 1H), 1.56 -1.40 (m, 2H), 1.29 (d, J = 6.3 Hz, 6H).
189 1 H NMR (400 MHz, DMS0-d6) δ 9.47 (s, 1 H), 8.97 (d, J = 2.2 Hz, 1 H), 8.82 (d, J =
2.2 Hz, 1 H), 8.77 (d, J = 7.1 Hz, 1 H), 8.61 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.85 (s, 1H), 7.21 (d, J =4.9 Hz, 1H),
4.40 (q, J = 7.4 Hz, 1 H), 4.22 (dt, J = 5.9, 2.8 Hz, 1 H), 4.04 (q, J = 6.7 Hz, 1 H), 2.14-1.99 (m, 1H), 1.89 (dddt, J = 21.0, 12.1, 7.7, 4.4 Hz, 2H), 1.76- 1.62 (m, 1H), 1.56- 1.42 (m, 2H), 1.29 (d
,J =6.3 Hz, 6H).
190 1 H NMR (400 MHz, DMS0-d6) δ 9.52 (s, 1 H), 8.98 (d, J = 2.2 Hz, 1 H), 8.83 (d, J =
2.2 Hz, 1 H), 8.66 (d, J = 7.7 Hz, 1 H), 8.60 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.83 (s, 1H), 7.22 (d, J =5.0 Hz, 1H),
4.25-4.11 (m, 1H), 4.13-4.00 (m, 1H), 3.97 (s, 1H), 1.77 (d, J = 12.2 Hz, 2H), 1.72- 1.60 (m, 1H), 1.53 (d, J = 12.8 Hz, 3H), 1.38 (t, J = 12.1 Hz, 1H), 1.29 (d, J =
6.3 Hz, 7H).
191 1 H NMR (400 MHz, DMS0-d6) δ 9.53 (d, J = 7.8 Hz, 1 H), 8.98 (d, J = 2.2 Hz, 1 H),
8.83 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 7.7 Hz, 1 H), 8.60 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1H), 7.83 (s, 1H), 7.22 (d, J = 5.0 Hz, 1H), 4.24-4.10 (m, 2H), 4.06 (h, J = 6.7 Hz, 1H), 3.97 (s, 1H), 1.77 (d, J = 12.7 Hz, 2H), 1.66 (t, J = 12.2 Hz, 1H), 1.58-1.44 (m, 3H), 1.38 (t, J = 11.6 Hz, 1 H), 1.29 (d, J = 6.3 Hz, 6H).
192 1 H NMR (400 MHz, DMSO-d6) δ 9.55 (d, J = 7.8 Hz, 1 H), 8.99 (d, J = 2.2 Hz, 1 H),
8.83 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 7.7 Hz, 1 H), 8.61 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1H), 7.83 (s, 1H), 7.22 (d, J = 5.0 Hz, 1H), 4.24-4.12 (m, 1H), 4.06 (h, J = 6.6 Hz, 1H), 3.97 (s, 1H), 1.77 (d, J = 12.6 Hz, 2H), 1.66 (t, J = 12.1 Hz, 1H), 1.59-1.45 (m, 3H), 1.43 - 1.34 (m, 1 H), 1.29 (d, J = 6.3 Hz, 7H).
193 1 H NMR (400 MHz, DMSO-d6) δ 9.63 - 9.47 (m, 1 H), 8.98 (d, J = 2.2 Hz, 1 H), 8.83
(d, J = 2.2 Hz, 1 H), 8.80 (d, J = 7.6 Hz, 1 H), 8.62 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.85 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.06 (h, J = 6.6 Hz, 1 H), 3.76 (ddt, J = 22.8, 9.0, 3.9 Hz, 1H), 3.43 (dt, J = 11.0, 6.5 Hz, 1H), 2.03 (d, J = 12.1 Hz, 1H), 1.79 (s, 2H), 1.70 (d, J = 12.5 Hz, 1H), 1.29 (d, J =6.3 Hz, 6H), 1.27-0.90 (m, 4H).
194
195 1 H NMR (400 MHz, DMSO-d6) 69.11 (s, 1 H), 8.96 (s, 1 H), 8.84 (d, J = 2.2 Hz,
1 H), 8.68 (s, 1 H), 7.99 (d, J = 4.9 Hz, 1 H), 7.96 (s, 1 H), 7.20 (d, J = 4.9 Hz, 1 H), 4.52 - 4.42 (m, 1 H), 4.34 (dd, J = 49.8, 9.3 Hz, 1 H), 4.01 - 3.85 (m, 2H), 3.84 - 3.65 (m, 2H), 2.40 (d, J = 7.8 Hz, 1 H), 1.91 (s, 1 H), 1.20 - 1.07 (m, 8H).
196 1H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 1.4 Hz, 2H), 8.53 (s, 1H), 8.13 (d,
J =3.2 Hz, 1H), 7.77 (d, J =5.1 Hz, 1H), 7.57-7.49 (m, 1H), 7.42 (d, J = 15.9 Hz, 2H), 7.14 (d, J =5.0 Hz, 1H), 4.79 (d, J =3.0 Hz, 4H), 4.55-4.30 (m, 1H), 4.10- 3.88 (m, 1 H), 3.79 (d, J = 2.8 Hz, 3H), 3.62 - 3.48 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
197 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 1.0 Hz,
1 H), 8.55 (dd, J = 11.7, 2.2 Hz, 1 H), 8.11 (d, J = 9.0 Hz, 1 H), 7.81 - 7.74 (m, 1 H), 7.60-7.51 (m, 1H), 7.49-7.39 (m, 2H), 7.15 (d, J =5.1 Hz, 1H), 4.98 (s, 2H), 4.46 (dd, J = 48.4, 8.5 Hz, 1H), 3.99 (dd, J =36.6, 15.2 Hz, 1H), 3.53 (dt, J = 15.0, 7.5 Hz, 1 H), 2.21 (d, J = 5.0 Hz, 3H), 1.30 (d, J = 1.6 Hz, 6H).
198 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (s, 1 H), 8.70 (d, J = 2.2 Hz, 1 H), 8.53 (d,
J = 2.1 Hz, 1 H), 8.25 (s, 1 H), 7.80 (d, J = 5.1 Hz, 1 H), 7.66 (d, J = 8.5 Hz, 2H), 7.53 (d, J = 8.4 Hz, 2H), 7.16 (d, J =5.1 Hz, 1H), 4.47 (ddd, J =49.1, 9.4, 2.1 Hz, 1 H), 4.22 (s, 2H), 3.98 (ddd, J = 36.4, 14.6, 2.1 Hz, 1 H), 3.69 (q, J = 9.3 Hz, 2H), 3.62 - 3.42 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
199 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.70 (s, 1 H), 8.60 (d,
J =2.2 Hz, 1H), 8.15-8.02 (m, 2H), 7.89-7.80 (m, 2H), 7.18 (d, J =5.1 Hz, 1H), 5.41 (tt, J = 7.2, 3.5 Hz, 1 H), 5.03 - 4.89 (m, 2H), 4.79 (ddd, J = 8.2, 5.8, 5.0 Hz, 2H), 4.46 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 4.13 - 3.77 (m, 2H), 3.68 - 3.42 (m, 2H), 2.73 (dt, J = 16.1, 7.9 Hz, 1H), 2.62-2.45 (m, OH), 1.30 (d, J = 1.7 Hz, 6H).
200 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 1.8 Hz, 2H), 8.53 (d, J = 2.1 Hz, compound 1H-NMR
1H), 8.17 (s, 1H), 7.79 (d, J = 5.1 Hz, 1H), 7.51 -7.43 (m, 4H), 7.16 (d, J = 5.1 Hz, 1H), 4.55 2H),4.47 (ddd, J =
49.0, 9.4, 2.1 Hz, 1H), 3.98 (ddd, J =36.6, 14.6, 2.1 Hz, 1H), 3.63-3.49 (m, 1H), 3.48 - 3.38 (m, 2H), 2.49 (t, J = 8.1 Hz, 2H), 2.19 - 1.98 (m, 2H), 1.30 (d, J = 1.6 Hz, 6H).
201 1 H NMR (400 MHz, Methanol-d4) δ 8.73 - 8.68 (m, 2H), 8.54 (d, J = 2.2 Hz, 1 H),
8.18 (s, 1H), 7.79 (d, J =5.0 Hz, 1H), 7.64-7.40 (m, 4H), 7.16 (d, J = 5.1 Hz, 1H), 4.56 - 4.50 (m, 3H), 4.44 - 4.33 (m, 3H), 3.99 (ddd, J = 36.6, 14.6, 2.2 Hz, 1 H), 3.66 - 3.56 (m, 2H), 3.58 - 3.45 (m, 1 H), 1.30 (d, J = 1.6 Hz, 7H).
202 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.2 Hz, 1 H), 8.68 (s, 1 H), 8.53 (d,
J = 2.2 Hz, 1 H), 8.20 (s, 1 H), 7.78 (d, J = 5.0 Hz, 1 H), 7.52 - 7.5 (m, 2H), 7.47 - 7.36 (m, 2H), 7.16 (d, J = 5.1 Hz,
1H), 4.47 (ddd, J = 49.1, 9.4, 2.1 Hz, 1H), 4.46 (s, 2H), 3.99 (ddd, J = 36.6, 14.6, 2.1 Hz, 1H), 3.61 -3.50 (m, 1H), 1.66 (ddd, J = 12.6, 8.0, 4.7 Hz, 1H), 1.30 (d, J = 1.6 Hz, 7H), 0.90 (dt, J = 4.
6, 3.0 Hz, 2H), 0.81 (dt, J = 8.1 , 3.2 Hz, 2H).
203 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.1 Hz, 1 H), 8.68 (s, 1 H), 8.54 (dd,
J =2.2, 0.4 Hz, 1H), 8.19 (s, 1H), 7.78 (dd, J = 5.1, 0.5 Hz, 1H), 7.50 (d, J =8.7 Hz, 2H), 7.46-7.40 (m, 2H), 7.16 (d, J =5.1 Hz, 1H), 4.47 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 4.44 (s, 2H), 3.99 (ddd, J =36.7, 14.5, 2.1 Hz, 1H), 3.65-3.43 (m, 1H), 2.54 (p, J = 6.9 Hz, 1H), 1.30 (d, J = 1.7 Hz, 6H), 1.17 (d, J
= 6.9 Hz, 6H).
204 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.1 Hz, 1 H), 8.69 (s, 1 H), 8.54 (d,
J =2.2 Hz, 1H), 8.18 (s, 1H), 7.78 (d, J =5.1 Hz, 1H), 7.50 (d, J = 8.4 Hz, 2H), 7.43 (d, J = 8.4 Hz, 2H), 7.16 (d, J =5.1 Hz, 1H), 4.47 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 4.45 (s, 2H), 3.99 (ddd, J = 36.6, 14.6, 2.1 Hz, 1H), 3.52 (ddd, J = 16.0, 14.5, 9.3 Hz, 1H), 2.31 (q, J =7.6 Hz, 2H), 1.30 (d, J = 1.6 Hz, 6H), 1.19 (t, J = 7.6 Hz, 3H).
205 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (s, 1 H), 8.70 (d, J = 2.1 Hz, 1 H), 8.56 (d,
J = 2.1 Hz, 1 H), 8.26 (s, 1 H), 7.81 (d, J = 5.1 Hz, 1 H), 7.67 (d, J = 8.2 Hz, 2H), 7.56 (d, J = 8.2 Hz, 2H), 7.16 (d, J =5.1 Hz, 1H), 4.49 (t, J = 11.1 Hz, 5H), 4.40 (s, 2H), 4.08-3.85 (m, 1H), 3.54 (td, J = 15.3, 9.3 Hz, 1H), 1.29 (d, J = 1.7 Hz, 6H).
206 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.70 (s, 1 H), 8.59 (d,
J =2.2 Hz, 1H), 8.14-8.05 (m, 2H), 7.85 (d, J = 5.1 Hz, 1H), 7.83 (s, 1H), 7.18 (d, J = 5.1 Hz, 1 H), 5.39 (s, 1 H), 4.96 (td, J = 7.7, 3.2 Hz, 2H), 4.83 - 4.72 (m, 2H), 4.70 (d, J = 6.0 Hz, 1H), 4.45 (ddd, J =49.1, 9.3, 2.1 Hz, 1H), 4.10-3.70 (m, 3H), 3.66 - 3.42 (m, 1 H), 2.73 (dd, J = 14.7, 7.7 Hz, 1 H), 2.61 - 2.45 (m, 1 H), 1.29 (d, J = 1.6 Hz, 6H).
207 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (s, 1 H), 8.70 (d, J = 2.2 Hz, 1 H), 8.57 (d,
J = 2.1 Hz, 1 H), 8.27 (s, 1 H), 7.89 (d, J = 8.6 Hz, 2H), 7.80 (d, J = 5.1 Hz, 1 H), 7.56 (d, J = 8.5 Hz, 2H), 7.47 (s, 1H), 7.16 (d, J =5.1 Hz, 1H), 4.59-4.31 (m, OH), 4.00 (dd, J =36.9, 14.4 Hz, 1H), 3.63-3.50 (m, 1 H), 2.56 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
208 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.70 (s, 1 H), 8.58 (d,
J = 2.1 Hz, 1 H), 8.11 (s, 1 H), 8.05 (s, 1 H), 7.85 (d, J = 5.1 Hz, 1 H), 7.80 (s, 1 H), 7.17 (d, J = 5.0 Hz, 1H), 5.31 (d, J =7.0 Hz, 2H), 4.45 (dd, J =48.8, 8.0 Hz, 1H), 4.07 - 3.82 (m, 1 H), 3.80 - 3.63 (m, 2H), 3.63 - 3.44 (m, 3H), 2.72 - 2.52 (m, 1 H), 2.45 (s, 1 H), 1.29 (d, J = 1.6 Hz, 6H).
209 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 1 H), 8.67 (d, J = 2.2 Hz, 1 H), 8.57 (d,
J = 2.2 Hz, 1 H), 8.49 (s, 1 H), 8.20 (d, J = 8.7 Hz, 2H), 7.84 (d, J = 5.0 Hz, 1 H), 7.67 (d, J = 8.7 Hz, 2H), 7.14 (d, J =5.0 Hz, 1H), 4.61 -4.35 (m, 1H), 4.11 -3.86 (m, 1 H), 3.64 - 3.50 (m, 1 H), 2.65 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
210 1 H NMR (400 MHz, Methanol-d4) δ 9.02 (s, 1 H), 8.77 (s, 1 H), 8.70 (d, J = 2.1 Hz,
1 H), 8.57 (d, J = 2.1 Hz, 1 H), 8.44 (s, 1 H), 7.85 (d, J = 5.1 Hz, 1 H), 7.81 (s, 1 H), 7.80-7.73 (m, 2H), 7.70 (d, J =
8.4 Hz, 2H), 7.17 (d, J =5.0 Hz, 1H), 4.47 (dd, J =48.9, 9.2 Hz, 1H), 3.97 (m, 4H), 3.55 (td, J = 15.4, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
211 1 H NMR (400 MHz, Methanol-d4) δ 8.85 (s, OH), 8.70 (d, J = 2.2 Hz, 1 H), 8.66 (s,
1H), 8.56 (d, J =2.1 Hz, 1H), 8.16 (s, 1H), 7.78 (d, J =5.1 Hz, 1H), 7.45-7.33 (m, 4H), 7.15 (d, J =5.1 Hz, 1H), 4.46 (ddd, J = 48.9, 9.2, 2.0 Hz, 1H), 4.10-3.84 (m, 1 H), 3.68 - 3.42 (m, 1 H), 2.02 (s, 3H), 1.32 (d, J = 3.1 Hz, 2H), 1.29 (d, J = 1.7 Hz, 6H), 1.27 (d, J = 1.7 Hz, 2H).
212 1 H NMR (400 MHz, Methanol-d4) δ 8.70 (d, J = 2.2 Hz, 1 H), 8.66 (s, 1 H), 8.57 (s,
1H), 8.25 (s, 1H), 7.80 (d, J = 5.1 Hz, 1H), 7.49-7.36 (m, 5H), 7.15 (d, J = 5.0 Hz, 1H), 4.57-4.31 (m, 1H), 3.99 (dd, J =36.9, 15.1 Hz, 1H), 3.69 (s, 3H), 3.60-3.42 (m, 1 H), 1.33 - 1.30 (m, 4H), 1.30 (d, J = 1.6 Hz, 6H).
213 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.2 Hz, 1 H), 8.70 (s, 1 H), 8.53 (d,
J = 2.2 Hz, 1 H), 8.29 (d, J = 2.6 Hz, 1 H), 7.97 (s, 1 H), 7.78 (d, J = 5.1 Hz, 1 H), 7.75 (dd, J =9.0, 2.8 Hz, 1H), 7.16 (d, J =5.0 Hz, 1H), 7.12 (d, J =9.0 Hz, 1H), compound 1H-NMR
4.46 (ddd, J =49.1, 9.3, 2.1 Hz, 1H), 4.10-3.94 (m, 1H), 3.91 (t, J =5.3 Hz, 4H), 3.86 - 3.81 (m, 1 H), 3.67 - 3.42 (m, 1 H), 3.37 (t, J = 5.3 Hz, 4H), 1.30 (d, J = 1.6 Hz, 6H).
214 1 H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 2.2 Hz, 1 H), 8.67 (s, 1 H), 8.61 (d,
J = 2.2 Hz, 1 H), 8.27 (s, 1 H), 7.83 (d, J = 5.1 Hz, 1 H), 7.67 - 7.52 (m, 2H), 7.38 (d, J =8.6 Hz, 2H), 7.15 (d, J =5.1 Hz, 1H), 4.47 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 3.99 (ddd, J =36.5, 14.6, 2.1 Hz, 1H), 3.61 (s, 3H), 3.52 (ddd, J = 16.2, 14.6, 9.4 Hz, 1 H), 1.66 (s, 6H), 1.30 (d, J = 1.6 Hz, 6H).
215 1 H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 2.2 Hz, 1 H), 8.66 (s, 1 H), 8.58 (d,
J = 2.1 Hz, 1 H), 8.34 (s, 1 H), 8.22 (s, 1 H), 7.81 (d, J = 5.0 Hz, 1 H), 7.63 - 7.54 (m, 2H), 7.38 (d, J =8.6 Hz, 2H), 7.15 (d, J =5.1 Hz, 1H), 4.47 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 3.99 (ddd, J =36.6, 14.5, 2.1 Hz, 1H), 3.64-3.42 (m, 1H),2.00 (s, 3H), 1.68 (s, 6H), 1.30 (d, J = 1.6 Hz, 6H).
216 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (s, 1 H), 8.69 (d, J = 2.2 Hz, 1 H), 8.56 (d,
J = 2.1 Hz, 1 H), 8.33 (s, 1 H), 8.31 (s, 1 H), 7.94 (d, J = 8.5 Hz, 2H), 7.81 (d, J = 5.1 Hz, 1H), 7.62 (s, 1H), 7.58 (d, J = 8.5 Hz, 2H), 7.15 (d, J =5.1 Hz, 1H), 4.57-4.33 (m, 1H), 3.99 (dd, J =36.5, 13.7 Hz, 1H), 3.65-3.43 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
217 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.72 (d, J = 2.2 Hz, 1 H), 8.64 (d,
J = 2.1 Hz, 1 H), 8.55 (d, J = 2.2 Hz, 1 H), 8.50 (d, J = 2.4 Hz, 1 H), 8.24 (s, 1 H), 7.87 (t, J =2.4 Hz, 1H), 7.85 (d, J = 5.1 Hz, 1H), 7.17 (d, J = 5.0 Hz, 1H), 7.07 (t, J = 72.6 Hz, 1H), 4.47 (ddd, J =48.9, 9.2, 2.0 Hz, 1H), 4.18-3.83 (m, 1H), 3.64- 3.44 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
218 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (s, 1 H), 8.70 (d, J = 2.2 Hz, 1 H), 8.60 (d,
J =2.2 Hz, 1H), 8.37 (s, 1H), 8.17 (d, J =8.6 Hz, 2H), 7.81 (d, J = 5.1 Hz, 1H), 7.60 (d, J = 8.6 Hz, 2H), 7.16 (d, J =5.1 Hz, 1H), 4.47 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 4.13-3.88 (m, 1H), 3.65-3.42 (m, 1H), 2.54 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
219 1 H NMR (400 MHz, Methanol-d4) δ 8.86 (s, 1 H), 8.75 (s, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.39 (s, 1 H), 8.36 - 8.26 (m, 1 H), 7.98 - 7.87 (m, 1 H), 7.82 (d, J = 5.3 Hz, 2H), 7.75-7.64 (m, 2H), 7.59 (d, J
= 7.5 Hz, 1H), 7.14 (d, J = 5.0 Hz, 1H), 4.60-4.31 (m, 1H), 4.00 (s, 1H), 3.68 - 3.51 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
220 1 H NMR (400 MHz, Methanol-d4) δ 8.70 (d, J = 1.7 Hz, 2H), 8.54 (d, J = 2.2 Hz,
1 H), 8.11 (s, 1 H), 7.80 (d, J = 5.1 Hz, 1 H), 7.55 (t, J = 7.8 Hz, 1 H), 7.37 (ddd, J = 10.3, 8.2, 2.3 Hz, 3H), 7.15 (d, J
= 5.1 Hz, 1 H), 4.47 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.44 (s, 2H), 3.98 (ddd, J = 36.5, 14.6, 2.1 Hz, 1H), 3.53 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 1.98 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
221 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (s, 1 H), 8.67 (d, J = 2.2 Hz, 1 H), 8.39 - 8.31 (m, 2H), 7.99 (d, J = 1.9 Hz, 1 H), 7.92 (dd, J = 7.5, 1.8 Hz, 1 H), 7.89 - 7.80 (m, 3H), 7.67 (s, 2H), 7.14 (d, J =5.0 Hz, 1H), 4.46 (dd, J =49.2, 7.9 Hz, 1H), 3.97 (dd, J = 36.3, 14.7 Hz, 1H), 3.67-3.47 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
222 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.70 (d, J = 2.1 Hz, 1 H), 8.59 (s,
1 H), 8.54 (d, J = 2.2 Hz, 1 H), 8.47 (s, 1 H), 8.24 (s, 1 H), 7.85 (d, J = 5.1 Hz, 1 H), 7.76 (s, 1H), 7.16 (d, J =5.0 Hz, 1H), 4.64-4.30 (m, 1H), 3.97 (dd, J = 36.6, 14.8 Hz, 1H), 3.53 (ddd, J = 16.4, 14.7, 9.3 Hz, 1H), 2.14 (dt, J =8.4, 3.7 Hz, 1H), 1.29 (d, J = 1.6 Hz, 6H), 1.25 - 1.09 (m, 2H), 0.96 - 0.78 (m, 2H).
223 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.69 (s, 1 H), 8.57 (d,
J = 2.2 Hz, 1 H), 8.11 (s, 1 H), 8.05 (d, J = 0.8 Hz, 1 H), 7.84 (d, J = 5.1 Hz, 1 H), 7.80 (s, 1H), 7.17 (d, J =5.1 Hz, 1H), 5.32 (t, J =6.9 Hz, 1H), 4.45 (ddd, J = 48.9, 9.3, 2.1 Hz, 1 H), 4.10 - 3.81 (m, 2H), 3.79 - 3.63 (m, 2H), 3.63 - 3.46 (m, 2H), 2.69 - 2.51 (m, 1 H), 2.44 (s, 1 H), 1.29 (d, J = 1.7 Hz, 6H).
224 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (d, J = 2.2 Hz, 1 H), 8.66 (s, 1 H), 8.60 (d,
J = 6.0 Hz, 1 H), 8.07 (s, 1 H), 8.01 (s, 1 H), 7.83 (d, J = 5.1 Hz, 1 H), 7.78 - 7.72 (m, 1H), 7.18 (d, J =5.1 Hz, 1H), 5.07 (s, 1H), 4.39 (dd, J =9.3, 2.1 Hz, 1H), 4.10- 3.76 (m, 3H), 3.71 (s, 3H), 3.69 - 3.41 (m, 3H), 2.49 (d, J = 9.2 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
225 1 H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 1.7 Hz, 2H), 8.52 (d, J = 2.2 Hz,
1 H), 8.21 (s, 1 H), 7.79 (d, J = 5.1 Hz, 1 H), 7.51 (d, J = 8.4 Hz, 2H), 7.42 (d, J = 8.3 Hz, 2H), 7.15 (d, J = 5.1 Hz, 1H), 4.53 (dd, J =9.4, 2.1 Hz, 1H), 4.36 (s, 2H), 3.98 (ddd, J =36.6, 14.6, 2.1 Hz, 1H), 3.69 (s, 3H), 3.53 (ddd, J = 16.2, 14.5, 9.3 Hz, 1H), 1.30 (d, J = 1.7 Hz, 7H).
226 1 H NMR (400 MHz, Methanol-d4) δ 8.91 - 8.84 (m, 1 H), 8.78 (s, 2H), 8.71 (d, J =
2.2 Hz, 1 H), 8.52 (d, J = 2.2 Hz, 1 H), 8.26 (s, 1 H), 8.22 (s, 1 H), 7.86 (d, J = 5.0 Hz, 1H), 7.17 (d, J =5.1 Hz, 1H), 7.06 (t, J =55.2 Hz, 1H), 4.47 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 4.00 (ddd, J =36.5, 14.6, 2.1 Hz, 1H), 3.54 (ddd, J = 16.2, 14.6, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
227 1 H NMR (400 MHz, Methanol-d4) δ 8.80 (d, J = 2.5 Hz, 1 H), 8.78 (s, 1 H), 8.71 (d,
J =2.2 Hz, 1H), 8.57 (d, J =2.2 Hz, 1H), 8.25 (s, 1H), 8.13 (dd, J =8.4, 2.5 Hz, compound 1H-NMR
1H), 7.91 (d, J =8.5 Hz, 1H), 7.86 (d, J =5.1 Hz, 1H), 7.16 (d, J =5.1 Hz, 1H), 6.82 (t, J = 55.2 Hz, 1 H), 4.47 (ddd, J = 49.0, 9.2, 2.1 Hz, 1 H), 3.99 (ddd, J = 36.4, 14.6, 2.1 Hz, 1H), 3.54 (td, J = 15.4, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
228 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (s, 1 H), 8.69 (d, J = 2.2 Hz, 1 H), 8.58 (d,
J = 2.2 Hz, 1 H), 8.36 (s, 1 H), 8.20 (d, J = 8.6 Hz, 2H), 8.04 (d, J = 0.9 Hz, 1 H), 7.83 (d, J = 5.1 Hz, 1H), 7.70-7.54 (m, 2H), 7.36 (d, J = 0.9 Hz, 1H), 7.15 (d, J = 5.1 Hz, 1 H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.99 (ddd, J = 36.4, 14.6, 2.1 Hz, 1H), 3.54 (ddd, J = 16.1, 14.6, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
229 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (s, 1 H), 8.70 (d, J = 2.2 Hz, 1 H), 8.54 (d,
J =2.2 Hz, 1H), 8.24 (dt, J = 5.0, 1.5 Hz, 1H), 8.18 (ddd, J =9.7, 7.7, 1.8 Hz, 1H), 8.09 (d, J = 1.4 Hz, 1 H), 7.88 (d, J = 5.1 Hz, 1 H), 7.54 (ddd, J = 7.7, 4.9, 1.1 Hz, 1H), 7.16 (d, J =5.1 Hz, 1H), 4.47 (ddd, J = 49.0, 9.4, 2.1 Hz, 1H), 3.99 (ddd, J = 36.5, 14.6, 2.1 Hz, 1H), 3.54 (ddd, J = 16.1, 14.6, 9.4 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
230 1 H NMR (400 MHz, Methanol-d4) δ 8.80 (s, 1 H), 8.68 (d, J = 2.2 Hz, 1 H), 8.63 (s,
1 H), 8.55 (d, J = 2.2 Hz, 1 H), 8.07 (d, J = 8.7 Hz, 2H), 7.87 (d, J = 5.1 Hz, 1 H), 7.82-7.72 (m, 2H), 7.68 (s, 2H), 7.16 (d, J =5.0 Hz, 1H), 4.59 - 4.29 (m, 1H), 3.97 (dd, J = 36.2, 14.5 Hz, 1H), 3.65-3.42 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
231 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (d, J = 2.2 Hz, 1 H), 8.68 (s, 1 H), 8.60 (d,
J =2.2 Hz, 1H), 8.10-8.06 (m, 2H), 7.87-7.82 (m, 2H), 7.17 (d, J =5.0 Hz, 1H), 5.30 (ddd, J = 8.0, 5.2, 2.7 Hz, 1 H), 4.50 (dd, J = 9.7, 7.7 Hz, 2H), 4.40 (dd, J = 9.2, 6.0 Hz, 2H), 3.97 (ddd, J =36.3, 14.5, 2.1 Hz, 1H), 3.72 (s, 3H), 3.60-3.39 (m, 1H), 1.29 (d, J = 1.7 Hz, 6H).
232 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.70 (s, 1 H), 8.57 (d,
J = 2.2 Hz, 1 H), 8.08 (s, 1 H), 8.01 (s, 1 H), 7.93 (s, 1 H), 7.84 (d, J = 5.0 Hz, 1 H), 7.17 (d, J = 5.0 Hz, 1H), 5.50 (p, J =7.2 Hz, 1H), 4.61 (dd, J =7.2, 4.0 Hz, 4H), 4.54-4.31 (m, 1H), 3.96 (dd, J = 36.3, 14.6 Hz, 1 H), 3.53 (td, J = 15.6, 9.5 Hz, 1H), 1.29 (d, J = 1.6 Hz, 6H).
233 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.70 (d, J = 2.2 Hz, 1 H), 8.62 (s,
1 H), 8.55 (d, J = 2.2 Hz, 1 H), 8.49 (s, 1 H), 8.24 (s, 1 H), 7.97 (s, 1 H), 7.85 (d, J = 5.0 Hz, 1H), 7.16 (d, J =5.0 Hz, 1H), 4.46 (ddd, J =49.0, 9.2, 2.1 Hz, 1H), 3.98 (ddd, J =36.4, 14.5, 2.1 Hz, 1H), 3.54 (td, J = 15.4, 9.4 Hz, 1H), 2.51 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
234 1 H NMR (400 MHz, Methanol-d4) δ 9.01 (d, J = 1.4 Hz, 1 H), 8.76 (s, 1 H), 8.70 (d,
J = 2.2 Hz, 1 H), 8.55 (d, J = 2.2 Hz, 1 H), 8.43 (s, 1 H), 8.00 (d, J = 1.4 Hz, 1 H), 7.94 (d, J = 8.5 Hz, 2H), 7.83 (d, J = 5.0 Hz, 1 H), 7.66 (d, J = 8.6 Hz, 2H), 7.16 (d, J = 5.1 Hz, 1 H), 4.47 (ddd, J = 48.9, 9.3, 2.1 Hz, 1 H), 4.08 - 3.84 (m, 1 H), 3.69 - 3.40 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
235 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.67 (s, 1 H), 8.58 (d,
J = 2.2 Hz, 1 H), 8.07 (s, 1 H), 8.01 (s, 1 H), 7.82 (d, J = 5.0 Hz, 1 H), 7.75 (d, J = 0.8 Hz, 1H), 7.17 (d, J = 5.0 Hz, 1H), 4.57 - 4.33 (m, 2H), 4.26 (d, J = 13.5 Hz, 2H), 4.07-3.86 (m, 1H), 3.71 (s, 3H), 3.52 (td, J = 15.3, 9.2 Hz, 1H), 3.06 (s, 3H), 2.17 (d, J = 12.8 Hz, 2H), 2.00 (td, J = 12.2, 4.4 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
236 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.2 Hz, 1 H), 8.69 (s, 1 H), 8.56 (d,
J = 2.2 Hz, 1 H), 8.11 (s, 1 H), 8.01 (d, J = 0.8 Hz, 1 H), 7.83 (d, J = 5.1 Hz, 1 H), 7.80 (d, J = 0.8 Hz, 1H), 7.17 (d, J =5.0 Hz, 1H), 4.63 (dt, J = 10.5,5.6 Hz, 1H), 4.45 (ddd, J = 48.9, 9.3, 2.1 Hz, 1 H), 4.08 - 3.84 (m, 1 H), 3.70 - 3.56 (m, 2H), 3.56 -3.43 (m, 1H), 3.28-3.19 (m, 2H), 2.48-2.21 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
237 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.66 (s, 1 H), 8.63 (d,
J =2.2 Hz, 1H), 8.12 (s, 1H), 8.02 (d, J =0.8 Hz, 1H), 7.83 (d, J = 5.1 Hz, 1H), 7.73 (d, J = 0.8 Hz, 1 H), 7.18 (d, J = 5.1 Hz, 1 H), 5.12 (td, J = 5.4, 2.8 Hz, 1 H), 4.45 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 4.22-4.10 (m, 2H), 4.05 (dd, J = 9.9, 5.8 Hz, 1H), 4.03-3.83 (m, 2H), 3.52 (ddd, J = 16.0, 14.5, 9.3 Hz, 1H), 2.68-2.46 (m, 1 H), 2.46 - 2.32 (m, 1 H), 1.29 (d, J = 1.7 Hz, 6H).
238 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.71 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.97 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.54 - 4.29 (m, 2H), 3.99 - 3.78 (m, 1 H), 3.59 (dd, J = 10.9, 7.8 Hz, 1 H), 3.49 (td, J = 15.0, 9.3 Hz, 1H), 3.34 (dd, J = 11.0, 3.3 Hz, 2H), 3.11 -2.92 (m, 2H), 2.26-2.09 (m, 1H), 2.04 (dt, J = 13.5, 6.2 Hz, 2H), 1.28 (d, J = 1.7 Hz, 6H).
239 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.2 Hz, 1 H), 8.67 (s, 1 H), 8.63 (d,
J =2.2 Hz, 1H), 8.12 (s, 1H), 8.02 (d, J =0.8 Hz, 1H), 7.83 (d, J = 5.1 Hz, 1H), 7.73 (d, J = 0.8 Hz, 1 H), 7.17 (d, J = 5.1 Hz, 1 H), 5.12 (td, J = 5.5, 2.9 Hz, 1 H), 4.45 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.23 - 4.09 (m, 2H), 4.09 - 3.98 (m, 2H), 3.98 -3.86 (m, 2H), 3.52 (ddd, J = 16.2, 14.5, 9.3 Hz, 1H), 2.56 (dtd, J = 13.4, 8.4, 6.9 Hz, 1 H), 2.47 - 2.30 (m, 1 H), 1.29 (d, J = 1.7 Hz, 6H).
240 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.74 (s, 1 H), 8.66 (d,
J =2.1 Hz, 1H), 8.19 (d, J =5.1 Hz, 1H), 8.07 (s, 1H), 7.20 (d, J = 5.1 Hz, 1H), 4.60-4.32 (m, 1H), 4.09-3.88 (m, 1H), 3.90-3.78 (m, 1H), 3.63 (d, J = 13.1 Hz, compound 1 H-NMR
1 H), 2.60 (s, 2H), 1.29 (d, J = 1.6 Hz, 7H).
241 1 H NMR (400 MHz, Methanol-d4) δ 8.70 (d, J = 2.2 Hz, 1 H), 8.68 (s, 1 H), 8.53 (d,
J = 2.2 Hz, 1 H), 8.16 (s, 1 H), 7.77 (d, J = 5.1 Hz, 1 H), 7.51 (d, J = 8.3 Hz, 2H), 7.43 (d, J = 8.4 Hz, 2H), 7.15 (d, J = 5.1 Hz, 1 H), 4.46 (ddd, J = 49.0, 9.3, 2.0 Hz, 1 H), 4.44 (s, 2H), 3.99 (ddd, J = 36.5, 14.4, 2.1 Hz, 1 H), 3.65 - 3.43 (m, 1 H), 2.04 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
242 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.04 (d, J = 5.0 Hz, 1 H), 7.89 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.10 (dd, J = 20.4, 12.3 Hz, 3H), 4.02 - 3.81 (m, 1 H), 3.71 (s, 3H), 3.48 (td, J = 15.5, 9.4 Hz, 1 H), 3.22 (s, 3H), 2.11 (d, J = 13.1 Hz, 2H), 1 .80 - 1.54 (m, 2H), 1.28 (d, J = 1.6 Hz, 6H).
243 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.04 (d, J = 5.1 Hz, 1 H), 7.89 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.09 (td, J = 9.8, 4.8 Hz, 1 H), 3.93 (ddd, J = 36.6, 14.5, 2.1 Hz, 1 H), 3.67 (d, J = 13.6 Hz, 2H), 3.48 (ddd, J = 16.0, 14.6, 9.4 Hz, 1 H), 3.20 - 3.03 (m, 2H), 2.88 (s, 6H), 2.13 (d, J = 12.9 Hz, 2H), 1.89 - 1.61 (m, 2H), 1.28 (d, J = 1 .6 Hz, 6H).
244 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.04 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.07 (dt, J = 9.9, 5.5 Hz, 1 H), 3.93 (ddd, J = 36.6, 14.5, 2.1 Hz, 1 H), 3.69 (d, J = 13.0 Hz, 2H), 3.49 (ddd, J = 16.0, 14.5, 9.4 Hz, 1 H), 3.26 - 3.13 (m, 2H), 2.84 (s, 6H), 2.17 (d, J = 13.1 Hz, 2H), 1.86 - 1.65 (m, 2H), 1.28 (d, J = 1 .6 Hz, 6H).
245 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (s, 1 H), 8.67 (s, 1 H), 8.62 (s, 1 H), 8.01 (d,
J = 5.1 Hz, 1 H), 7.88 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.41 (ddd, J = 49.3, 9.4, 2.0 Hz, 1 H), 4.01 - 3.83 (m, 2H),
3.64 - 3.44 (m, 3H), 3.16 - 3.07 (m, OH), 2.97 (d, J = 10.7 Hz, 6H), 2.25 (s, 2H), 2.02 (t, J = 18.2 Hz, 2H), 1.28 (d, J = 1 .6 Hz, 6H).
246 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.41 (dd, J = 50.1 , 8.6 Hz, 2H), 4.05 - 3.83 (m, 1 H), 3.77 (dd, J = 11.2, 8.0 Hz, 1 H), 3.64 - 3.40 (m, 4H), 3.07 - 2.79 (m, 2H), 2.62 (dt, J = 14.0, 7.8 Hz, 2H), 2.08 (s, 3H), 1.65 (ddd, J = 19.9, 13.4, 7.0 Hz, 2H), 1 .28 (d, J = 1 .6 Hz, 6H).
247 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.43 (dd, J = 48.8, 7.9 Hz, 1 H), 4.24 (t, J = 7.6 Hz, 1 H), 3.95 (dd, J = 36.4, 14.3 Hz, 1 H), 3.57 - 3.39 (m, 1 H), 2.91 (s, 4H), 2.60 (dt, J = 13.4, 6.9 Hz, 2H), 1.61 (dt, J = 13.8, 8.1 Hz, 2H), 1.28 (d, J = 1.6 Hz, 6H).
248 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.52 - 4.26 (m, 1 H), 4.02 - 3.76 (m, 1 H), 3.58 - 3.45 (m, 1 H), 3.42 (dd, J = 12.1 , 7.3 Hz, 2H), 3.16 - 2.95 (m, 2H), 2.68 (dd, J = 13.2, 6.8 Hz, 2H), 1.70 - 1.46 (m, 2H), 1 .28 (d, J = 1.6 Hz, 6H).
249 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.92 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.53 - 4.29 (m, 2H), 3.92 (dd, J = 36.4, 14.6 Hz, 1 H), 3.80 (dd, J = 11.2, 8.0 Hz, 1 H), 3.68 (dd, J = 12.6, 8.4 Hz, 1 H), 3.46 (ddd, J = 17.4, 11.8, 4.4 Hz, 3H), 3.02 (ddd, J = 32.2, 8.3, 4.3 Hz, 1 H), 2.29 - 2.13 (m, 2H), 2.13 - 1 .96 (m, 5H), 1 .28 (d, J = 1.6 Hz, 6H).
250 1 H NMR (400 MHz, Methanol-d4) δ 8.80 (d, J = 2.2 Hz, 1 H), 8.74 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.19 (s, 1 H), 7.97 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.57 - 4.29 (m, 2H), 3.92 (dd, J = 36.1 , 14.8 Hz, 1 H), 3.48 (td, J = 15.4, 9.3 Hz, 1 H), 3.37 - 3.31 (m, 4H), 3.02 (d, J = 7.0 Hz, 2H), 2.92 (s, 3H), 2.18 (t, J = 9.3 Hz, 2H), 2.04 (dt, J = 13.9, 7.5 Hz, 2H), 1.28 (d, J = 1.6 Hz, 7H).
251 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.62 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.59 - 4.43 (m, 2H), 4.35 (dd, J = 9.4, 2.1 Hz, 1 H), 3.91 (ddd, J = 36.3, 14.5, 2.1 Hz, 1 H), 3.64 - 3.43 (m, 3H), 3.27 - 3.04 (m, 4H), 2.12 (dt, J = 13.5, 6.4 Hz, 5H), 1 .28 (d, J = 1.7 Hz, 6H).
252 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.15 (p, J = 6.4 Hz, 1 H), 3.59 - 3.43 (m, 2H), 2.01 - 1.93 (m, 2H), 1 .42 (s, 6H), 1.40 (d, J = 6.4 Hz, 6H).
253 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.3 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.61 (d, J = 14.8 Hz, 1 H), 8.04 (d, J = 5.2 Hz, 1 H), 7.93 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (dd, J = 48.8, 9.2 Hz, 1 H), 4.16 - 3.75 (m, 1 H), 3.50 (ddd, J = 23.4, 19.2, 12.0 Hz, 3H), 2.18 (s, 3H), 2.00 - 1 .83 (m, 2H), 1.76 (s, 1 H), 1.28 (d, J = 1 .7 Hz, 7H).
254 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz, compound 1H-NMR
1 H), 8.61 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.95 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.49 (dd, J =9.4, 2.1 Hz, 1H), 4.40-4.30 (m, 1H), 4.16 (s, 1H), 4.02-3.83 (m, 1 H), 3.80 - 3.73 (m, 1 H), 3.73 - 3.61 (m, 2H), 3.43 - 3.33 (m, 1 H), 3.28 - 3.15 (m, 1H), 3.09 (s, 1H), 2.91 (s, 3H), 2.08 (d, J = 12.1 Hz, 1H), 1.92 (dd, J = 14.0, 8.3 Hz, 1 H), 1.88 - 1.78 (m, 2H), 1.28 (d, J = 1.6 Hz, 6H).
255 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (s, 1 H), 8.65 (d,
J =2.1 Hz, 1H), 8.10 (d, J =5.1 Hz, 1H), 7.91 (s, 1H), 7.20 (d, J = 5.0 Hz, 1H), 4.49 (dd, J =9.2, 2.1 Hz, OH), 4.42-4.23 (m, 1H), 4.12-3.81 (m, 1H), 3.64 (d, J = 12.5 Hz, 1H), 3.51 (td, J = 15.2, 9.2 Hz, 1H), 3.40 (d, J = 12.8 Hz, 1H), 3.18-2.98 (m, 1H), 2.28 (d, J = 12.5 Hz, 1H), 2.12 (d, J = 15.1 Hz, 1H), 1.99 (d, J = 10.9 Hz, OH), 1.88 (t, J = 11.6 Hz, 1H), 1.29 (d, J = 1.6 Hz, 6H).
256 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.71 (m, 1 H), 8.67 (d, J = 2.2 Hz, 1 H),
8.60 (s, 1 H), 8.04 (d, J = 5.0 Hz, 1 H), 7.94 (s, 1 H), 7.88 (s, OH), 7.21 (d, J = 5.1 Hz, 1H), 4.47 (dd, J =9.3, 2.1 Hz,
1H), 4.35 (dd, J =9.3, 2.1 Hz, 1H), 4.20 (s, OH), 4.12 (d, J = 13.6 Hz, 1H), 3.97 (dd, J = 14.7, 2.5 Hz, 2H), 3.91 - 3.74 (m, 1H), 3.68 (dd, J = 13.8, 6.5 Hz, 1H), 3.63 -3.40 (m, 2H), 2.18 (s, 3H),
1.92 (dd, J = 12.1, 6.2 Hz, 1H), 1.82- 1.65 (m, 2H), 1.28 (d, J = 1.6 Hz, 6H).
257 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.96 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J =49.1, 9.3, 2.1 Hz, 1H), 4.15 (s, 1H), 4.05-3.83 (m, 1H), 3.71 (d, J = 10.7 Hz, 1H), 3.58 -3.35 (m, 2H), 3.26 - 3.13 (m, 1H), 2.91 (s, 3H), 2.08 (s, 1H), 1.93 (s, 2H), 1.84 (t, J = 8.4 Hz, 2H), 1.28 (d, J = 1.6 Hz, 6H).
258 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.66 (s, 1 H), 8.65 (d,
J = 2.1 Hz, 1 H), 8.09 (d, J = 5.0 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.2, 9.3, 2.1 Hz, 1 H), 4.34 - 4.19 (m, OH), 4.08 - 3.79 (m, 1 H), 3.67 -3.58 (m, 1H), 3.57-3.44 (m, 1H), 3.40 (d, J = 12.8 Hz, 1H), 3.21 -3.00 (m, 2H), 2.28 (d, J = 12.5 Hz, 1H), 2.12 (d, J = 14.0 Hz, 1H), 2.05- 1.93 (m, OH), 1.88 (t, J = 11.8 Hz, 1 H), 1.29 (d, J = 1.7 Hz, 7H)6
259 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
2H), 8.25 (s, 1 H), 7.93 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.57 - 4.27 (m, 2H), 4.03 - 3.70 (m, 2H), 3.71 - 3.41 (m, 2H), 2.99 (s, 1 H), 2.93 (s, 3H), 2.28 (s, 1 H), 2.20 - 1.91 (m, 1 H), 1.74 (s, 1 H), 1.28 (d, J = 1.7 Hz, 6H).
260 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
2H), 8.27 (s, 1H), 7.93 (s, 1H), 7.19 (d, J =5.1 Hz, 1H), 4.47 (dt, J = 14.5, 7.2 Hz, 2H), 4.36 (dd, J = 9.3, 2.1 Hz, 1 H), 4.05 - 3.71 (m, 2H), 3.67 - 3.41 (m, 1 H), 2.92 (s, 5H), 2.27 (s, 1H), 2.19 -1.91 (m, 3H), 1.74 (s, 1H), 1.28 (d, J = 1.7 Hz, 6H).
261 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.83 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.48 (dd, J =9.4, 2.1 Hz, 1H), 4.44-4.28 (m, 2H), 4.12 (td, J =7.8, 4.9 Hz, 1H), 3.93 (ddd, J =36.6, 14.6, 2.1 Hz, 1H), 3.47 (ddd, J = 16.0, 14.5, 9.4 Hz, 1H), 2.42- 2.23 (m, 1H), 2.00 (dddd, J = 20.9, 18.9,9.9,5.3 Hz, 2H), 1.88 - 1.60 (m, 3H), 1.28 (d, J = 1.7 Hz, 7H).
262 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (d, J = 2.1 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.01 (s, 1 H), 7.95 (d, J = 5.0 Hz, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.55-4.30 (m, 1H), 4.15 (q, J = 5.5 Hz, 1H), 4.02 (d, J = 6.2 Hz, 1H), 3.93 (dd, J = 35.4, 15.3 Hz, 1H), 3.61 - 3.40 (m, 1H), 2.37 (dd, J = 13.6, 7.7 Hz, 1H), 2.13-2.01 (m, 1 H), 1.86 (s, OH), 1.80 - 1.58 (m, 1 H), 1.28 (d, J = 1.7 Hz, 6H).
263 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.71 (s, 1 H), 8.67 (d,
J = 2.2 Hz, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.90 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.56 - 4.33 (m, 2H), 4.06 - 3.83 (m, 2H), 3.62 - 3.36 (m, 6H), 2.57 - 2.48 (m, 1 H), 2.32 - 2.05 (m, 4H), 1.29 (d, J = 1.7 Hz, 6H).
264 1 H NMR (400 MHz, Methanol-d4) δ 8.49 (d, J = 2.2 Hz, 1 H), 8.43 (s, 1 H), 8.21 (d,
J =2.1 Hz, 1H), 7.33 (d, J =4.7 Hz, 1H), 7.13-6.94 (m, 2H), 4.21 -3.92 (m, 6H), 3.76 - 3.51 (m, 3H), 2.59 - 2.44 (m, 2H), 2.26 - 2.06 (m, 4H), 1.24 - 1.09 (m, 6H).
265 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.89 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.02 - 3.85 (m, 1 H), 3.61 - 3.41 (m, 1 H), 2.42 (dd, J = 8.6, 7.5 Hz, 2H), 2.15-2.00 (m, 4H), 1.93- 1.70 (m, 7H), 1.30 (d, J = 1.7 Hz, 6H).
266 1 H NMR (400 MHz, DMS0-d6) δ 9.69 (s, 1 H), 9.00 (s, 1 H), 8.94 (s, 1 H), 8.82 (d, J
= 2.2 Hz, 1H), 8.78 (s, 1H), 8.02 (s, 1H), 7.94 (d, J =4.9 Hz, 1H), 7.19 (d, J =4.9 Hz, 1 H), 6.53 (s, 1 H), 4.89 (s, 1 H), 4.37 (ddd, J = 49.3, 9.5, 2.1 Hz, 1 H), 4.20 (s, 1 H), 3.86 (t, J = 11.2 Hz, 1 H), 3.81 - 3.65 (m, 1 H), 3.34 - 3.21 (m, 2H), 2.56 - 2.49 (m, 1H), 2.40-2.32 (m, 2H), 2.12-1.81 (m, 5H), 1.18 (dd, J =5.6, 1.6 Hz, 6H).
267 1 H NMR (499 MHz, Methanol-d4) δ 8.77 (s, 2H), 8.56 (s, 1 H), 8.43 (s, 1 H), 7.94 (d,
J = 5.0 Hz, 1 H), 7.23 (d, J = 5.0 Hz, 1 H), 4.35 (s, 2H), 3.60 (s, 3H), 2.30 - 2.20 (m, 6H), 2.18-2.07 (m, 6H).
268 1 H NMR (499 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.66 (d, J = 2.1 Hz, compound 1 H-NMR
1 H), 8.58 (s, 1 H), 8.02 (d, J = 5.0 Hz, 1 H), 7.92 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.37 (s, 2H), 3.90 - 3.79 (m, 1 H), 3.64 (s, 3H), 3.54 - 3.47 (m, 1 H), 2.22 (d, J = 12.5 Hz, 2H), 2.08 (d, J = 12.5 Hz, 2H), 1 .56 (tt, J = 24.3, 12.1 Hz, 4H).
269 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.43 (ddd, J = 49.2, 9.5, 2.0 Hz, 1 H), 4.04 - 3.81 (m, 2H), 3.59 - 3.41 (m, 2H), 2.37 (s, 3H), 2.31 - 2.15 (m, 4H), 1.72 - 1.53 (m, 4H), 1.30 (d, J = 1.6 Hz, 6H).
270 1 H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.70 (m, 2H), 8.52 (s, 1 H), 8.36 (s, 1 H),
7.92 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 3.93 - 3.77 (m, 1 H), 3.68 - 3.63 (m, 4H), 3.64 - 3.54 (m, 4H), 3.40 - 3.34 (m, 4H), 2.28 - 2.07 (m, 12H), 2.08 - 1.94 (m, 4H), 1.56 - 1.35 (m, 4H).
271 1 H NMR (400 MHz, Methanol-d4) δ 8.81 - 8.71 (m, 2H), 8.52 (s, 1 H), 8.36 (s, 1 H),
7.92 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 3.95 - 3.80 (m, 1 H), 3.74 - 3.62 (m, 1 H), 3.60 (s, 3H), 2.31 - 2.08 (m, 12H), 2.07 - 1.93 (m, 4H), 1.62 - 1.35 (m, 5H), 0.87 - 0.80 (m, 2H), 0.79 - 0.69 (m, 2H).
272 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.77 (d, J = 2.2 Hz,
1 H), 8.53 (s, 1 H), 8.46 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.0, 9.6, 2.1 Hz, 1 H), 3.92 (ddd, J = 36.6, 14.5, 2.1 Hz, 1 H), 3.56 - 3.41 (m, 1 H), 2.88 (s, 6H), 2.32 - 2.07 (m, 12H), 1.29 (d, J = 1.6 Hz, 6H).
273 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 3.93 (ddd, J = 36.5, 14.6, 2.2 Hz, 1 H), 3.84 - 3.71 (m, 1 H), 3.56 - 3.39 (m, 1 H), 2.33 - 2.19 (m, 2H), 2.10 - 1.95 (m, 2H), 1.53 - 1 .33 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H), 1.27 - 1.14 (m, 7H).
274 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.50 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.85 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 3.91 - 3.78 (m, 1 H), 3.64 (s, 3H), 3.56 - 3.44 (m, 1 H), 2.93 (s, 3H), 2.28 - 2.14 (m, 2H), 2.12 - 2.01 (m, 2H), 1.66 - 1 .42 (m, 4H).
275 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1 H), 8.52 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 3.92 - 3.76 (m, 2H), 2.93 (s, 3H), 2.33 - 2.17 (m, 2H), 2.14 - 1.96 (m, 2H), 1.75 - 1 .50 (m, 4H).
276 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.1 Hz,
1 H), 8.50 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.84 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 3.94 - 3.64 (m, 2H), 2.93 (s, 3H), 2.28 - 2.15 (m, 2H), 2.1 1 - 1.99 (m, 2H), 1.95 (s, 3H), 1.55 (h, J = 12.0 Hz, 4H).
277 1 H NMR (400 MHz, Methanol-d4) δ 8.87 - 8.75 (m, 2H), 8.66 (d, J = 12.6 Hz, 2H),
7.98 (d, J = 5.1 Hz, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 4.14 (q, J = 9.3 Hz, 2H), 2.67 (s, 6H), 1.99 (s, 3H).
278 1 H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.74 (m, 2H), 8.64 (d, J = 8.6 Hz, 2H),
7.98 (d, J = 5.1 Hz, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 6.05 (tt, J = 56.0, 4.0 Hz, 1 H), 3.77 (td, J = 15.1 , 4.0 Hz, 2H), 2.67 (s, 6H), 1.98 (s, 3H).
279 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (t, J = 3.0 Hz, 2H), 8.54 (s, 1 H), 8.37 (s,
1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 5.38 - 5.28 (m, 1 H), 4.93 - 4.84 (m, 2H), 4.63 - 4.55 (m, 2H), 4.52 - 4.31 (m, 1 H), 4.02 - 3.80 (m, 1 H), 3.55 - 3.39 (m, 1 H), 2.33 - 2.18 (m, 6H), 2.17 - 2.06 (m, 6H), 1.29 (d, J = 1.6 Hz, 6H).
280 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.3 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.88 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 5.42 - 5.29 (m, 1 H), 4.92 - 4.85 (m, 2H), 4.65 - 4.57 (m, 2H), 4.42 (ddd, J = 48.9, 9.3, 1.9 Hz, 1 H), 4.03 - 3.77 (m, 2H), 3.56 - 3.40 (m, 2H), 2.28 - 2.18 (m, 2H), 2.14 - 1.98 (m, 2H), 1.65 - 1.45 (m, 4H), 1 .29 (d, J = 1 .6 Hz, 6H).
281 1 H NMR (400 MHz, Methanol-d4) δ 8.88 - 8.68 (m, 2H), 8.54 (s, 1 H), 8.41 (s, 1 H),
7.93 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.0, 9.6, 2.0 Hz, 1 H), 3.92 (ddd, J = 37.0, 14.5, 2.0 Hz, 1 H), 3.53 - 3.40 (m, 1 H), 2.32 - 2.07 (m, 12H), 1 .68 - 1.46 (m, 1 H), 1.29 (d, J = 1 .6 Hz, 6H), 0.86 - 0.75 (m, 2H), 0.75 - 0.63 (m, 2H).
282 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.1 Hz,
1 H), 8.57 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.88 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.87 - 4.86 (m, 2H), 4.52 - 4.33 (m, 3H), 4.03 - 3.73 (m, 3H), 3.55 - 3.40 (m, 1 H), 2.30 - 2.17 (m, 2H), 2.12 - 1.99 (m, 2H), 1.69 - 1.48 (m, 7H), 1.30 (d, J = 1.6 Hz, 6H).
283 1 H NMR (400 MHz, Methanol-d4) δ 8.82 - 8.68 (m, 2H), 8.55 (s, 1 H), 8.38 (s, 1 H),
7.94 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 3.91 (ddd, J = 36.6, 14.5, 2.1 Hz, 1 H), 3.59 - 3.39 (m, 1 H), 2.32 - 2.18 (m, 6H), 2.15 - 2.05 (m, 6H), 1.29 (d, J = 1.6 Hz, 6H).
284 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.89 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 48.6, 9.2, 1.9 Hz, 1 H), 4.05 - 3.79 (m, 5H), 3.54 - 3.45 (m, 1 H), 3.43 compound 1 H-NMR
(s, 3H), 2.30 - 2.17 (m, 2H), 2.10 - 2.00 (m, 2H), 1.68 - 1.53 (m, 4H), 1 .29 (d, J = 1.6 Hz, 6H).
285 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.53 - 4.27 (m, 1 H), 4.03 - 3.71 (m, 2H), 3.56 - 3.41 (m, 2H), 2.77 (s, 6H), 2.28 - 2.07 (m, 4H), 1.67 - 1.49 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
286 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.43 (ddd, J = 49.1 , 9.2, 2.1 Hz, 1 H), 4.04 - 3.86 (m, 1 H), 3.86 - 3.75 (m, 1 H), 3.69 - 3.57 (m, 1 H), 3.55 - 3.41 (m, 1 H), 2.91 (s, 6H), 2.33 - 2.16 (m, 2H), 2.12 - 2.00 (m, 2H), 1.64 - 1.47 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
287 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.1 Hz,
1 H), 8.57 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.88 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.02 - 3.78 (m, 4H), 3.58 - 3.39 (m, 2H), 2.27 - 2.15 (m, 2H), 2.12 - 2.02 (m, 2H), 1 .67 - 1 .44 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H), 1 .12 (s, 1 H), 0.63 - 0.49 (m, 2H), 0.31 - 0.22 (m, 2H).
288 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.87 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.97 - 4.86 (m, 1 H), 4.52 - 4.31 (m, 1 H), 4.02 - 3.75 (m, 2H), 3.57 - 3.37 (m, 2H), 2.39 - 2.26 (m, 2H), 2.26 - 2.16 (m, 2H), 2.12 - 2.00 (m, 4H), 1.85 - 1 .72 (m, 1 H), 1 .70 - 1.44 (m, 5H), 1.29 (d, J = 1.6 Hz, 6H).
289 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.88 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.56 - 4.28 (m, 1 H), 4.03 - 3.81 (m, 2H), 3.82 - 3.65 (m, 2H), 3.58 - 3.42 (m, 1 H), 3.08 - 2.99 (m, 1 H), 2.43 - 2.26 (m, 2H), 2.26 - 2.14 (m, 2H), 1.66 - 1 .47 (m, 4H), 1 .29 (d, J = 1.6 Hz, 6H).
290 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.1 Hz,
1 H), 8.57 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.88 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 4.03 - 3.76 (m, 4H), 3.57 - 3.40 (m, 2H), 2.21 (d, J = 10.6 Hz, 2H), 2.07 (d, J = 10.9 Hz, 2H), 1.98 - 1.83 (m, 1 H), 1.69 - 1 .44 (m, 4H), 1.29 (d, J = 1 .6 Hz, 6H), 0.95 (d, J = 6.7 Hz, 6H).
291 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.88 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 3.94 (ddd, J = 36.6, 14.6, 2.1 Hz, 1 H), 3.86 - 3.74 (m, 1 H), 3.58 - 3.41 (m, 2H), 2.21 (d, J = 11.8 Hz, 2H), 2.07 (d, J = 11 .8 Hz, 2H), 1.64 - 1.42 (m, 4H), 1.29 (d, J = 1.7 Hz, 6H), 1.23 (d, J = 6.3 Hz, 6H).
292 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.14 - 4.02 (m, 2H), 4.02 - 3.74 (m, 2H), 3.58 - 3.39 (m, 2H), 2.26 - 2.16 (m, 2H), 2.14 - 2.02 (m, 2H), 1.65 - 1.44 (m, 4H), 1 .29 (d, J = 1.6 Hz, 6H), 1.24 (t, J = 7.1 Hz, 3H).
293 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.1 Hz,
1 H), 8.58 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.88 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.83 (ddd, J = 49.0, 9.3, 1.9 Hz, 1 H), 4.02 - 3.79 (m, 2H), 3.64 (s, 3H), 3.59 - 3.42 (m, 2H), 2.27 - 2.16 (m, 2H), 2.13 - 2.03 (m, 2H), 2.03 (s, 3H), 1.66 - 1 .44 (m, 10H).
294 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.03 - 3.66 (m, 4H), 3.55 - 3.38 (m, 4H), 2.44 (tt, J = 11.6, 3.9 Hz, 1 H), 2.22 (d, J = 1 1.4 Hz, 2H), 2.04 (d, J = 10.9 Hz, 2H), 1.93 - 1 .48 (m, 8H), 1.29 (d, J = 1.7 Hz, 6H).
295 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.72 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.33 (s, 1 H), 7.94 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.40 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.00 - 3.81 (m, 1 H), 3.56 - 3.40 (m, 1 H), 2.34 - 2.18 (m, 12H), 1 .28 (d, J = 1.7 Hz, 6H).
296 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.90 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.43 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.02 - 3.87 (m, 1 H), 3.79 (d, J = 23.1 Hz, 2H), 3.57 - 3.42 (m, 1 H), 2.29 - 2.18 (m, 2H), 2.03 - 1.94 (m, 2H), 1.67 - 1 .50 (m, 4H), 1 .29 (d, J = 1.6 Hz, 6H), 1 .20 (s, 9H).
297 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.86 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.41 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.02 - 3.68 (m, 3H), 3.54 - 3.40 (m, 1 H), 2.26 - 2.17 (m, 2H), 2.1 1 - 2.03 (m, 2H), 1 .64 - 1 .49 (m, 5H), 1.28 (d, J = 1.7 Hz, 6H), 0.88 - 0.81 (m, 2H), 0.78 - 0.70 (m, 2H).
298 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.1 Hz,
1 H), 8.56 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.87 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.2, 1.9 Hz, 1 H), 4.04 - 3.64 (m, 3H), 3.57 - 3.40 (m, 1 H), 2.51 - 2.35 (m, 1 H), 2.29 - 2.16 (m, 2H), 2.08 - 1 .99 (m, 2H), 1.67 - 1.45 (m, 4H), 1 .29 compound 1 H-NMR
(d, J = 1.7 Hz, 6H), 1.11 (d, J = 6.8 Hz, 6H).
299 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.43 (ddd, J = 48.8, 9.4, 1.9 Hz, 1 H), 4.03 - 3.66 (m, 3H), 3.48 (td, J = 15.8, 9.3 Hz, 1 H), 2.28 - 2.15 (m, 4H), 2.11 - 2.00 (m, 2H), 1.69 - 1.44 (m, 4H), 1 .29 (d, J = 1.6 Hz, 6H), 1 .14 (t, J = 7.6 Hz, 3H).
300 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.65 (d, J = 2.2, 0.5
Hz, 1 H), 8.53 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 3.97 - 3.75 (m, 2H), 3.67 - 3.61 (m, 6H), 3.59 - 3.35 (m, 2H), 2.28 - 2.16 (m, 2H), 2.12 - 1.94 (m, 6H), 1.69 - 1 .29 (m, 8H).
301 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.72 (m, 1 H), 8.64 (dd, J = 2.2, 0.4 Hz,
1 H), 8.54 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.85 (s, 1 H), 7.21 (d, J = 5.1 , 0.4 Hz, 1 H), 3.94 - 3.78 (m, 2H), 3.79 - 3.60 (m, 2H), 2.25 - 2.19 (m, 2H), 2.09 - 2.03 (m, 3H), 1.99 (d, J = 14.0 Hz, 3H), 1.95 (s, 3H), 1.93 (s, 3H), 1.65 - 1.29 (m, 8H).
302 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.1 Hz,
1 H), 8.56 (s, 1 H), 8.46 (s, 1 H), 8.09 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.3, 2.2 Hz, 1 H), 4.03 (dd, J = 11 .4, 4.9 Hz, 1 H), 3.93 (ddd, J = 36.4, 14.6, 2.2 Hz, 1 H), 3.55 - 3.38 (m, 1 H), 3.24 (dd, J = 1 1.4, 9.2 Hz, 1 H), 2.76 - 2.68 (m, 1 H), 1.47 - 1.34 (m, 1 H), 1.29 (d, J = 1.7 Hz, 6H), 1 .14 - 0.99 (m, 2H).
303 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.1 Hz,
1 H), 8.56 (s, 1 H), 8.46 (s, 1 H), 8.09 (d, J = 5.0 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.43 (ddd, J = 49.1 , 9.3, 2.2 Hz, 1 H), 4.03 (dd, J = 11 .4, 4.9 Hz, 1 H), 3.93 (ddd, J = 36.4, 14.6, 2.1 Hz, 1 H), 3.54 - 3.41 (m, 1 H), 3.24 (dd, J = 1 1.4, 9.2 Hz, 1 H), 2.73 (dt, J = 7.3, 3.7 Hz, 1 H), 1 .45 - 1 .34 (m, 1 H), 1.29 (d, J = 1.7 Hz, 6H), 1 .14 - 0.99 (m, 2H).
304 1 H NMR (400 MHz, Methanol-d4) δ 8.80 (s, 1 H), 8.77 (d, J = 2.1 Hz, 1 H), 8.54 (s,
1 H), 8.41 (s, 1 H), 7.92 (d, J = 5.0 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 3.92 (ddd, J = 36.6, 14.6, 2.2 Hz, 1 H), 3.56 - 3.40 (m, 1 H), 2.30 - 2.16 (m, 6H), 2.14 - 2.03 (m, 6H), 1.45 (s, 9H), 1.29 (d, J = 1.6 Hz, 6H).
305 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.1 Hz,
1 H), 8.57 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.03 - 3.77 (m, 2H), 3.58 - 3.38 (m, 2H), 2.28 - 2.14 (m, 2H), 2.13 - 1.98 (m, 2H), 1 .65 - 1 .39 (m, 13H), 1.29 (d, J = 1 .6 Hz, 6H).
306 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.52 - 4.28 (m, 3H), 3.94 (ddd, J =
36.5, 14.5, 2.1 Hz, 1 H), 3.55 - 3.41 (m, 1 H), 2.51 - 2.40 (m, 1 H), 2.29 - 2.18 (m, 1 H), 2.17 - 2.10 (m, 2H), 1.96 (s, 3H), 1.86 - 1 .61 (m, 2H), 1.29 (d, J = 1.7 Hz, 6H).
307 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.43 (ddd, J = 49.0, 9.3, 2.0 Hz, 1 H), 4.34 - 4.20 (m, 2H), 3.93 (ddd, J = 36.7, 14.6, 2.2 Hz, 1 H), 3.60 - 3.41 (m, 1 H), 2.66 (dt, J = 14.0, 7.2 Hz, 1 H), 2.40 - 2.25 (m, 1 H), 2.17 - 2.05 (m, 1 H), 1.96 (s, 3H), 1.93 - 1 .83 (m, 1 H), 1.85 - 1.71 (m, 1 H), 1.67 (dt, J = 13.3, 6.6 Hz, 1 H), 1 .29 (d, J = 1.6 Hz, 6H).
308 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.63 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.88 (s, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.57 - 4.33 (m, 2H), 4.00 - 3.82 (m, 2H), 3.58 - 3.43 (m, 1 H), 2.57 - 2.47 (m, 1 H), 2.44 - 2.32 (m, 1 H), 2.34 - 2.22 (m, 2H), 1.95 - 1.77 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
309 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.64 (s, 1 H), 8.03 (d, J = 5.0 Hz, 1 H), 7.88 (s, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.51 - 4.31 (m, 2H), 3.92 (ddd, J =
36.5, 14.6, 2.1 Hz, 1 H), 3.77 (p, J = 7.7 Hz, 1 H), 3.59 - 3.43 (m, 1 H), 2.88 (dt, J = 14.3, 7.5 Hz, 1 H), 2.44 - 2.20 (m, 2H), 2.01 - 1 .85 (m, 2H), 1 .71 (dt, J = 13.3, 8.1 Hz, 1 H), 1 .29 (d, J = 1 .6 Hz,
6H).
310 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.64 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.88 (s, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.52 - 4.32 (m, 2H), 3.92 (ddd, J =
36.5, 14.6, 2.1 Hz, 1 H), 3.77 (p, J = 7.6 Hz, 1 H), 3.60 - 3.44 (m, 1 H), 2.88 (dt, J = 14.4, 7.6 Hz, 1 H), 2.45 - 2.20 (m, 2H), 2.01 - 1 .85 (m, 2H), 1 .70 (dt, J = 13.3, 8.2 Hz, 1 H), 1 .29 (d, J = 1 .6 Hz,
6H).
311 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 2H), 8.54 (s, 1 H), 8.38 (s, 1 H), 7.93 (d,
J = 5.0 Hz, 1 H), 7.23 (d, J = 5.0 Hz, 1 H), 4.52 - 4.29 (m, 1 H), 4.01 - 3.81 (m, 1 H), 3.60 (s, 3H), 3.54 - 3.40 (m, 1 H), 2.30 - 2.17 (m, 6H), 2.16 - 2.05 (m, 6H), 1.29 (d, J = 1 .6 Hz, 6H).
312 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), compound 1H-NMR
4.54-4.19 (m, 3H), 4.04-3.82 (m, 1H), 3.58-3.42 (m, 1H), 2.66 (dt, J = 14.0, 7.2 Hz, 1H), 2.39-2.27 (m, 1H), 2.17-2.05 (m, 1H), 1.96 (s, 3H), 1.93 -1.73 (m, 2H), 1.66 (dt, J = 13.4, 6.6 Hz, 1H), 1.29 (d, J = 1.6 Hz, 6H).
313 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.02 (d, J = 5.0 Hz, 1 H), 7.88 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.56 - 4.28 (m, 1 H), 4.03 - 3.79 (m, 3H), 3.57 - 3.39 (m, 1 H), 2.33 - 2.20 (m, 2H), 2.15-2.04 (m, 2H), 1.76- 1.54 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
314 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.53 - 4.24 (m, 1 H), 4.02 - 3.78 (m, 2H), 3.64 (s, 3H), 3.55 - 3.40 (m, 2H), 2.30 - 2.14 (m, 2H), 2.13-2.00 (m, 2H), 1.67 - 1.42 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
315 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.42 (dd, J = 49.0, 7.6 Hz, 1 H), 4.02 - 3.79 (m, 2H), 3.58 - 3.41 (m, 2H), 2.99 (s, 3H), 2.30-2.09 (m, 4H), 1.68- 1.48 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
316 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.03 (d, J = 5.0 Hz, 1 H), 7.87 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 4.02-3.81 (m, 2H), 3.50 (ddd, J = 16.1, 14.5, 9.4 Hz, 1H), 3.23 (tt, J = 11.4, 3.6 Hz, 1H), 2.34-2.25 (m, 2H), 2.24-2.14 (m, 2H), 1.79 - 1.54 (m, 4H), 1.29 (d, J = 1.7 Hz, 6H).
317 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.74 (dd, J = 2.2, 0.5
Hz, 1 H), 8.54 (s, 1 H), 8.35 (s, 1 H), 7.97 - 7.87 (m, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 3.92 (ddd, J =36.6, 14.5, 2.2 Hz, 1H), 3.47 (ddd, J = 16.0, 14.8, 9.4 Hz, 1H), 2.26-2.15 (m, 12H), 1.90 (s, 3H), 1.29 (d, J = 1.7 Hz, 6H).
318 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.1 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.26 (s, 1 H), 7.96 (d, J = 5.0 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.0, 9.5, 2.1 Hz, 1 H), 4.00 - 3.79 (m, 1 H), 3.57 - 3.41 (m, 1 H), 2.40 -2.26 (m, 6H), 2.14-2.00 (m, 6H), 1.29 (d, J = 1.6 Hz, 6H).
319 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.63 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.87 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.54-4.32 (m, 1H), 4.23-4.14 (m, 1H), 4.03-3.83 (m, 2H), 3.60-3.43 (m, 1H), 2.12-1.86 (m, 6H), 1.82- 1.62 (m, 2H), 1.30 (d, J = 1.7 Hz, 6H).
320 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.1 Hz,
1 H), 8.62 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.87 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.43 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 4.17-4.08 (m, 1H), 4.02-3.81 (m, 2H), 3.60 - 3.45 (m, 1 H), 1.96 (s, 9H), 1.71 - 1.54 (m, 2H), 1.30 (d, J = 1.6 Hz, 6H).
321 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.73 (m, 2H), 8.67 (d, J = 2.2 Hz, 1 H),
8.55 (d, J = 0.7 Hz, 1 H), 8.46 (s, 1 H), 8.08 (d, J = 5.1 Hz, 1 H), 7.20 (d, J = 5.1 Hz, 1H), 4.52-4.30 (m, 1H), 4.02 (dd, J = 11.4, 4.9 Hz, 1H), 3.92 (dd, J =36.4, 14.6 Hz, 1 H), 3.53 - 3.40 (m, 1 H), 3.23 (dd, J = 11.4, 9.2 Hz, 1 H), 2.72 (dt, J = 7.3, 3.7 Hz, 1H), 1.43- 1.33 (m, 1H), 1.28 (d, J = 1.6 Hz, 6H), 1.14-0.98 (m, 2H).
322 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.53 (dtd, J =49.3, 9.3, 5.0 Hz, 1H), 4.30 (qd, J = 11.1, 4.8 Hz, 1H), 4.14 (dt, J = 15.0, 5.5 Hz, 2H), 3.93 (d, J = 11.9 Hz, 1H), 3.53 (td, J = 11.6, 2.4 Hz, 1H), 3.41 (ddd, J = 11.1, 9.4, 4.1 Hz, 1H), 2.19-2.05 (m, 1H), 1.75 (qd, J = 11.5, 4.6 Hz, 1H), 1.41 (dd, J =6.4, 1.7 Hz, 6H).
323 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.53 (dtd, J = 49.3, 9.3, 4.9 Hz, 1 H), 4.30 (qd, J = 11.1 , 4.9 Hz, 1 H), 4.22 - 4.07 (m, 2H), 3.98 - 3.88 (m, 1 H), 3.53 (td, J = 11.6, 2.4 Hz, 1 H), 3.41 (ddd, J = 11.1 , 9.4, 4.1 Hz, 1H), 2.18-2.05 (m, 1H), 1.75 (qd, J = 11.6, 4.6 Hz, 1H), 1.41 (dd, J =6.4, 1.7 Hz, 6H).
324 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.05 (d, J = 5.1 Hz, 1 H), 7.91 (s, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.67 - 4.28 (m, 2H), 4.26 - 4.03 (m, 2H), 4.02 - 3.82 (m, 1 H), 3.62 - 3.37 (m, 1 H), 3.26 - 3.04 (m, 1 H), 2.30 - 2.05 (m, 2H), 1.82 - 1.39 (m, 3H), 1.40 - 1.32 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
325 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.05 (d, J = 5.1 Hz, 1 H), 7.91 (s, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.98 (d, J = 5.9 Hz, 2H), 4.52 - 4.33 (m, 4H), 4.23 - 4.11 (m, 1 H), 3.93 (dd, J = 36.2, 14.4 Hz, 1H), 3.58-3.42 (m, 1H), 3.30 - 3.18 (m, 2H), 3.19-3.07 (m, 1H), 2.23-2.12 (m, 2H), 1.78- 1.61 (m, 5H), 1.29 (d, J = 1.7 Hz, 6H).
326 1 H NMR (400 MHz, Methanol-d4) δ 8.99 (t, J = 5.4 Hz, 1 H), 8.75 (d, J = 2.2 Hz,
1 H), 8.64 (d, J = 2.1 Hz, 1 H), 8.57 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.3, 2.0 Hz, 1 H), 4.04 - 3.80 (m, 2H), 3.79 - 3.67 (m, 1 H), 3.57 - 3.41 (m, 1 H), 2.22 (d, J = 11.2 Hz, 2H), 2.05 (d, J = 11.7 Hz, 2H), 1.95 (s, 3H), 1.65 - 1.45 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H). compound 1H-NMR
327 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.62 (d, J = 0.8 Hz, 1 H), 8.04 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.55 - 4.32 (m, 2H), 3.94 (dd, J = 36.3, 14.5 Hz, 1 H), 3.56 - 3.42 (m, 3H), 2.90 (dd, J = 17.4, 5.5 Hz, 1H), 2.51 (dd, J = 17.4, 8.1 Hz, 1H), 2.34 - 2.19 (m, 1H), 2.12-1.96 (m, 1H), 1.29 (d, J = 1.7 Hz, 6H).
328 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.05 (d, J = 5.0 Hz, 1 H), 7.91 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.52 - 4.33 (m, 2H), 4.24 - 4.12 (m, 3H), 4.01 - 3.85 (m, 2H), 3.57 - 3.35 (m, 5H), 3.21 -3.08 (m, 1H), 2.25-2.12 (m, 2H), 1.79- 1.53 (m, 2H), 1.29 (d, J = 1.7 Hz, 6H).
329 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.43 (ddd, J =49.1, 9.4, 2.2 Hz, 1H), 4.04-3.83 (m, 2H), 3.50 (ddd, J = 16.0, 14.5, 9.4 Hz, 1H), 3.21 (q, J =9.8 Hz, 2H), 3.10-2.99 (m, 2H), 2.83-2.68 (m, 2H), 2.15 (d, J = 13.0 Hz, 2H), 1.88- 1.72 (m, 2H), 1.30 (d, J = 1.7 Hz, 6H).
330 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (dd, J = 2.2, 0.4
Hz, 1 H), 8.54 (s, 1 H), 8.03 - 7.97 (m, 1 H), 7.83 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.15 (p, J = 6.4 Hz, 1H), 3.76 (dd, J = 13.7, 2.8 Hz, 1H), 3.57 (dd, J = 9.4, 2.8 Hz, 1H), 1.40 (d, J =6.4 Hz, 6H), 1.25 (d, J =4.4 Hz, 6H). (1H obscured by solvent)
331 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.30 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.72 (t, J = 11.9 Hz, 2H), 4.41 (t,
J = 12.1 Hz, 2H), 4.07 (s, 2H), 2.31 -2.16 (m, 6H), 1.90 (dd, J = 10.3, 5.7 Hz, 6H).
332 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.67 (d, J = 2.1 Hz,
1 H), 8.59 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.84 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.58 (s, 2H), 4.16 (p, J =6.4 Hz, 1H), 1.40 (d, J =6.4 Hz, 6H), 1.38 (s, 6H).
333 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.29 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.24 (s, 2H), 3.11 (s, 3H), 3.00 (s, 3H), 2.31 -2.15(m, 6H), 1.96- 1.76 (m, 6H).
334 1 H NMR (400 MHz, Methanol-d4) δ 8.33 (s, 1 H), 6.85 (s, 1 H), 3.91 (s, 2H), 2.74 (s,
3H), 2.15-1.95 (m, 8H), 1.89- 1.65 (m, 8H).;1H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.71 (d, J = 2.2 Hz, 1 H), 8.60 (s, 1 H), 8.31 (s, 1 H), 7.93 (d, J =5.0 Hz, 1H), 7.22 (d, J = 5.1 Hz, 1H), 4.00 (s, 2H), 2.78 (s, 3H), 2.30-2.17 (m, 6H), 1.90 (dd, J = 10.1, 5.9 Hz, 6H).
335 1 H NMR (400 MHz, Methanol-d4) δ 9.70 (s, 1 H), 8.85 (s, 1 H), 8.71 (s, 1 H), 8.32 (s,
1H), 7.65 (d, J =5.0 Hz, 1H), 7.41 -7.22 (m, 5H), 7.19 (d, J =5.0 Hz, 1H), 4.48 (dd, J = 48.6, 9.1 Hz, 1H), 4.28 (s, 2H), 3.99 (dd, J = 36.6, 15.4 Hz, 1H), 3.68- 3.48 (m, 1H), 1.31 (d, J = 1.6 Hz, 6H).
336 1 H NMR (400 MHz, Methanol-d4) δ 8.94 (s, 1 H), 8.69 (d, J = 2.2 Hz, 1 H), 8.56 (d,
J = 2.1 Hz, 1 H), 7.90 (d, J = 5.1 Hz, 1 H), 7.41 - 7.37 (m, 3H), 7.36 - 7.28 (m, 1 H), 7.17 (d, J = 5.0 Hz, 1H), 4.58-4.34 (m, 1H), 4.27 (s, 2H), 3.98 (ddd, J =36.1, 14.5, 2.2 Hz, 1H), 3.63-3.50 (m, 1H), 1.30 (d, J = 1.7 Hz, 6H).
337 1 H NMR (400 MHz, Methanol-d4) δ 9.68 (s, 1 H), 8.81 (s, 1 H), 8.63 (s, 1 H), 8.11 (s,
1H), 7.62 (s, 1H), 7.32 (d, J = 3.4 Hz, 4H), 7.26 (d, J =7.6 Hz, 1H), 7.13 (d, J =5.0 Hz, 1 H), 6.89 (s, 1 H), 4.47 (ddd, J = 48.9, 9.2, 2.1 Hz, 1 H), 4.11 (s, 2H), 3.98 (ddd, J = 36.1 , 14.5, 2.3 Hz, 1 H), 3.61 - 3.49 (m, 1 H), 1.31 (d, J = 1.7 Hz, 6H).
338 1 H NMR (400 MHz, Methanol-d4) δ 9.78 (s, 1 H), 8.84 (s, 1 H), 8.67 (d, J = 2.2 Hz,
1H), 8.56 (d, J =2.2 Hz, 1H), 7.94 (d, J =5.0 Hz, 1H), 7.85 (s, 1H), 7.17 (d, J =5.0 Hz, 1H), 4.57-4.32 (m, 1H), 3.97 (dd, J = 35.4, 13.6 Hz, 1H), 3.61 -3.39 (m, 1H), 2.94 (s, 3H), 1.31 (d, J = 1.6 Hz, 6H).
339 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.1 Hz,
1 H), 8.61 (s, 1 H), 8.30 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.59 (q, J = 7.4 Hz, 1 H), 3.76 (s, 3H), 2.32 - 2.14 (m, 6H), 1.99 - 1.83 (m, 6H), 1.51 (d, J =7.4 Hz, 3H).
340 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.1 Hz,
1 H), 8.61 (s, 1 H), 8.30 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.59 (q, J = 7.3 Hz, 1 H), 3.76 (s, 3H), 2.30 - 2.17 (m, 6H), 1.97 - 1.82 (m, 6H), 1.51 (d, J =7.4 Hz, 3H).
341 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.30 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.12 (s, 2H), 3.77 (s, 3H), 2.31 -2.19 (m, 6H), 1.96- 1.82 (m, 6H).
342 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.50 (s, 1 H), 8.26 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 3.54-3.47 (m, 2H), 3.02 (s, 3H), 2.30-2.18 (m, 6H), 2.02- 1.93 (m, 2H), 1.90 (t, J = 8.1 Hz, 6H), 1.40 (s,6H).
343 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.1 Hz,
1 H), 8.47 (s, 1 H), 8.25 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 3.56 (s, 3H), 3.42 - 3.35 (m, 2H), 2.25 (t, J = 7.8 Hz, 6H), 2.05 - 1.96 (m, 2H), 1.90 compound 1 H-NMR
(dd, J = 10.3, 5.7 Hz, 6H), 1.31 (s, 6H).
344 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.1 Hz,
1 H), 8.47 (s, 1 H), 8.25 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 3.39 - 3.33 (m, 3H), 2.31 - 2.16 (m, 6H), 2.16 - 2.04 (m, 2H), 1.91 (d, J = 7.5 Hz, 8H), 1.34 (s, 6H).
345 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.1 Hz,
1 H), 8.53 (s, 1 H), 8.30 (s, 1 H), 7.93 (d, J = 5.0 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 3.52 - 3.43 (m, 2H), 2.32 - 2.18 (m, 6H), 2.02 - 1.83 (m, 8H), 1.41 (s, 6H).
346 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.48 (s, 1 H), 8.25 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 3.99 - 3.82 (m, 2H), 3.74 (td, J = 8.0, 6.3 Hz, 1 H), 3.46 (t, J = 7.1 Hz, 2H), 2.24 (dd, J = 10.4, 5.6 Hz, 6H), 2.14 - 2.01 (m, 1 H), 1 .92 (ddt, J = 11.4, 7.5, 5.7 Hz, 8H), 1 .87 - 1.75 (m, 2H), 1.55 (dq, J = 12.0, 8.0 Hz, 1 H).
347 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.48 (s, 1 H), 8.25 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 3.43 - 3.33 (m, 2H), 2.29 - 2.19 (m, 6H), 2.00 (dd, J = 9.6, 6.5 Hz, 2H), 1.95 - 1 .85 (m, 6H), 1.42 (s, 9H), 1.29 (s, 6H).
348 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.33 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.34 (s, 2H), 2.34 - 2.19 (m, 6H), 2.02 - 1.81 (m, 6H).
349 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (s, 1 H), 8.71 (d, J = 2.2 Hz, 1 H), 8.61 (d,
J = 2.2 Hz, 1 H), 8.35 (s, 1 H), 7.85 (d, J = 8.5 Hz, 2H), 7.82 (d, J = 5.0 Hz, 1 H), 7.58 (d, J = 8.5 Hz, 2H), 7.17 (d, J = 5.1 Hz, 1 H), 4.57 - 4.36 (m, 3H), 4.25 (t, J = 7.9 Hz, 2H), 4.1 1 - 3.91 (m, 1 H), 3.61 - 3.49 (m, 1 H), 2.41 (p, J = 7.8 Hz, 2H), 1.30 (d, J = 1.6 Hz, 6H).
350 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (s, 1 H), 8.70 (d, J = 2.2 Hz, 1 H), 8.60 (d,
J = 2.2 Hz, 1 H), 8.38 (s, 1 H), 8.04 - 7.96 (m, 2H), 7.82 (d, J = 5.1 Hz, 1 H), 7.62 - 7.53 (m, 2H), 7.16 (d, J = 5.1 Hz, 1 H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.99 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.53 (ddd, J = 16.2, 14.5, 9.3 Hz, 1 H), 2.97 (s, 3H), 1.30 (d, J = 1 .6 Hz, 6H).
351 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.77 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.43 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.07 (p, J = 7.8 Hz, 1 H), 4.02 - 3.83 (m, 1 H), 3.58 - 3.40 (m, 1 H), 3.19 - 3.05 (m, 2H), 2.69 (s, 3H), 2.19 (q, J = 9.3 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H). (1 H obscured by solvent)
352 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.53 (s, 1 H), 8.30 (s, 1 H), 7.93 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 3.63 (t, J = 6.4 Hz, 2H), 2.80 (t, J = 6.4 Hz, 2H), 2.25 (dd, J = 10.4, 5.6 Hz, 6H), 1 .95 - 1.83 (m, 6H).
353 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 8.29 (s, 1 H), 7.93 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.71 - 4.44 (m, 1 H), 3.90 (ddd, J =
35.6, 14.5, 2.2 Hz, 1 H), 3.49 (td, J = 15.5, 9.3 Hz, 1 H), 2.35 - 2.14 (m, 6H), 1.99 - 1 .79 (m, 6H), 1.47 (t, J = 1 .4 Hz, 3H), 1 .42 (t, J = 1.7 Hz, 3H).
354 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.1 Hz,
1 H), 8.53 (s, 1 H), 8.28 (s, 1 H), 7.93 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.47 (ddd, J = 48.9, 9.5, 2.1 Hz, 1 H), 3.89 (ddd, J = 36.9, 14.6, 2.1 Hz, 1 H), 3.56 - 3.38 (m, 1 H), 2.29 - 2.17 (m, 6H), 1.97 - 1.82 (m, 6H), 1.27 (dd, J = 3.3, 1.7 Hz, 6H). (OMe obscured by solvent)
355 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.47 (s, 1 H), 8.26 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 3.53 - 3.43 (m, 2H), 2.30 - 2.17 (m, 6H), 1.90 (dd, J = 10.3, 5.7 Hz, 6H), 1.84 - 1.73 (m, 2H), 1.26 (s, 6H).
356 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (t, J = 1.6 Hz, 2H), 8.56 (s, 1 H), 7.89 (t, J
= 2.5 Hz, 2H), 7.21 (d, J = 5.1 Hz, 1 H), 5.04 - 4.91 (m, 1 H), 4.54 - 4.29 (m, 1 H), 4.07 - 3.78 (m, 1 H), 3.58 - 3.40 (m, 1 H), 2.96 (dd, J = 1 1.8, 8.1 Hz, 2H), 2.67 (s, 3H), 2.45 (t, J = 9.9 Hz, 2H), 1.66 (s, 3H), 1.29 (d, J = 1.6 Hz, 6H).
357 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.45 (d, J = 1 .0 Hz, 1 H), 8.22 (s, 1 H), 7.92 (d, J = 5.0 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 2.24 (dd, J = 9.5, 6.4 Hz, 6H), 1.96 - 1.81 (m, 6H), 1.45 (s, 9H).
358 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.47 (s, 1 H), 8.26 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 2.30 - 2.17 (m, 6H), 1.90 (dd, J = 10.2, 5.8 Hz, 6H).
359 1 H NMR (400 MHz, Methanol-d4) δ 9.93 (s, 1 H), 8.75 (s, 1 H), 8.57 (d, J = 2.2 Hz,
1 H), 8.25 (s, 1 H), 7.87 (d, J = 8.6 Hz, 2H), 7.81 (d, J = 5.0 Hz, 1 H), 7.45 - 7.36 (m, 2H), 7.30 (s, 1 H), 7.20 - 7.12 (m, 1 H), 7.12 - 7.06 (m, 3H), 6.96 (d, J = 8.6 Hz, 2H), 4.49 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.07 - 3.86 (m, 1 H), 3.54 (td, J = 15.4, 9.4 Hz, 1 H), 1.32 (d, J = 1 .6 Hz, 6H). compound 1H-NMR
360 1 H NMR (400 MHz, Methanol-d4) δ 8.87 (d, J = 3.8 Hz, 2H), 8.67 (d, J = 2.2 Hz,
1H), 8.58 (d, J = 2.2 Hz, 1H), 7.95 (d, J =5.0 Hz, 1H), 7.16 (d, J =5.0 Hz, 1H), 6.21 (s, 1H), 4.47 (ddd, J =49.0, 9.3, 2.2 Hz, 1H), 3.97 (ddd, J =35.9, 14.6, 2.1 Hz, 1 H), 3.61 - 3.48 (m, 1 H), 1.40 (s, 9H), 1.30 (d, J = 1.6 Hz, 6H).
361 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.1 Hz,
1 H), 8.47 (s, 1 H), 8.25 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 2.90 (s, 3H), 2.31 -2.18 (m, 7H), 1.99- 1.79 (m, 5H).
362 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.83 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.43 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 4.15 (s, 1H), 3.96 (ddd, J =36.4, 14.6, 2.1 Hz, 1H), 3.49 (ddd, J = 15.8, 14.4, 9.4 Hz, 1H), 2.72 (s, 3H), 2.37 (t, J =6.8 Hz, 1H), 2.08- 1.97 (m, 3H), 1.94- 1.76 (m, 6H), 1.29 (d, J = 1.6 Hz, 6H).
363 1H NMR (400 MHz, Methanol-d4) δ 10.12 (s, 1H), 8.84 (s, 1H), 8.66 (s, 1H), 8.33
(s, 1 H), 7.98 (d, J = 7.3 Hz, 2H), 7.89 (d, J = 5.0 Hz, 1 H), 7.49 (s, 1 H), 7.42 (q, J = 10.1, 8.4 Hz, 3H), 7.18 (d, J =
5.0 Hz, 1H), 4.61 -4.37 (m, 1H), 4.00 (dd, J = 35.4, 14.6 Hz, 1H), 3.55 (td, J = 15.4, 9.2 Hz, 1H), 1.32 (d, J = 1.6 Hz, 6H).
364 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (s, 1 H), 8.65 (d, J = 2.2 Hz, 1 H), 8.39 (d,
J =2.2 Hz, 1H), 8.17 (s, 1H), 7.85-7.77 (m, 3H), 7.68-7.62 (m, 2H), 7.50-7.43 (m, 2H), 7.43-7.35 (m, 1H), 7.31 -7.25 (m, 2H), 7.12 (d, J =5.1 Hz, 1H), 7.01 (s, 1H), 4.42 (ddd, J = 49.1, 9.3, 2.1 Hz, 1H), 3.91 (ddd, J =36.5, 14.5, 2.1 Hz, 1H), 3.48 (ddd, J = 16.0, 14.5, 9.3 Hz, 1H), 2.39 (s, 3H), 1.28 (t, J = 1.3 Hz, 6H).
365
366 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.91 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.22 (dt, J = 9.3, 5.2 Hz, 1 H), 4.09 (s, 1 H), 3.92 (t, J = 11.8 Hz, 1 H), 3.25 (d, J = 12.0 Hz, 1H), 2.88 (s, 6H), 2.20 (t, J = 14.1 Hz, 5H), 2.04 (d, J = 15.2 Hz, 2H), 1.92 (d, J =9.2 Hz, 1H), 1.71 (q, J = 15.2, 12.0 Hz, 5H), 1.54 (q, J = 12.4, 11.5 Hz, 3H).
367 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.93 - 7.87 (m, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.53 - 4.32 (m, 1 H), 4.08 (q, J = 5.8 Hz, 1 H), 3.93 (ddd, J = 36.4, 14.6, 2.1 Hz, 1H), 3.71 (d, J =5.3 Hz, 2H), 3.49 (td, J = 15.2, 9.4 Hz, 1H), 2.56-2.25 (m, 3H), 2.00 (dt, J = 13.2, 4.5 Hz, 1H), 1.28 (d, J = 1.6 Hz, 6H).
368 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.93 - 7.87 (m, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.53 - 4.32 (m, 1 H), 4.08 (q, J = 5.8 Hz, 1 H), 3.93 (ddd, J = 36.4, 14.6, 2.1 Hz, 1H), 3.71 (d, J =5.3 Hz, 2H), 3.49 (td, J = 15.2, 9.4 Hz, 1H), 2.56-2.25 (m, 3H), 2.00 (dt, J = 13.2, 4.5 Hz, 1H), 1.28 (d, J = 1.6 Hz, 6H).
369 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1 H), 8.65 (dd, J = 2.2, 0.4
Hz, 1 H), 8.53 (s, 1 H), 7.98 (dd, J = 5.1 , 0.5 Hz, 1 H), 7.83 (d, J = 0.5 Hz, 1 H), 7.20 (d, J = 5.1 Hz, 1H), 4.21 (td, J
= 7.4, 6.6, 5.6 Hz, 1H), 4.17 - 4.09 (m, 1H), 1.40 (d, J =6.4 Hz, 6H), 1.28 (d, J = 6.6 Hz, 6H).
370 1H NMR (400 MHz, Methanol-d4) δ 9.12 (s, 1H), 8.74-8.65 (m, 2H), 8.22 (d, J =
2.1 Hz, 1 H), 7.85 (d, J = 2.4 Hz, 1 H), 7.55 (dd, J = 5.1 , 0.5 Hz, 1 H), 7.44 - 7.34 (m, 3H), 7.34 - 7.27 (m, 2H), 7.17 (d, J = 5.0 Hz, 1 H), 6.33 (d, J = 2.4 Hz, 1 H), 5.41 (s, 2H), 4.46 (ddd, J = 49.0, 9.3, 2.2 Hz, 1 H), 3.99 (ddd, J = 36.4, 14.5, 2.1 Hz, 1 H), 3.60 - 3.44 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
371 1H NMR (400 MHz, Methanol-d4) δ 9.15 (s, 1H), 8.73 (d, J = 2.2 Hz, 1H), 8.71 (s,
1 H), 8.65 (d, J = 2.2 Hz, 1 H), 7.87 (dd, J = 5.0, 0.5 Hz, 1 H), 7.67 (d, J = 2.3 Hz, 1H), 4.09-3.84 (m, 1H), 7.20 (d,
J = 5.0 Hz, 1 H), 6.30 (d, J = 2.4 Hz, 1 H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.96 (s, 3H), 3.61 - 3.44 (m, 1 H), 1.30 (d, J = 1.7 Hz, 6H).
372 1H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 2.2 Hz, 1H), 8.66 (s, 1H), 8.15 (s,
1 H), 8.06 (d, J = 0.8 Hz, 1 H), 8.04 (d, J = 2.2 Hz, 1 H), 7.78 (d, J = 5.0 Hz, 1 H), 7.73 (d, J = 0.8 Hz, 1H), 7.44 -7.31 (m, 5H), 7.16 (d, J = 5.1 Hz, 1 H), 5.44 (s, 2H), 4.45 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 3.97 (ddd, J =36.5, 14.5, 2.1 Hz, 1H), 3.51 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 1.29 (d, J = 1.6 Hz, 7H).
373 1 H NMR (400 MHz, Methanol-d4) δ 8.84 (d, J = 2.1 Hz, 1 H), 8.76 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.50 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J =49.0, 9.4, 2.0 Hz, 1H), 3.93 (ddd, J =36.5, 14.6, 2.1 Hz, 1H), 3.47 (td, J = 15.8, 9.4 Hz, 1H), 2.61 (s, 6H), 1.28 (d, J = 1.6 Hz, 6H).
374 1H NMR (400 MHz, Methanol-d4) δ 10.03 (s, 1H), 8.84 (s, 1H), 8.70 (d, J = 2.2 Hz,
1 H), 8.52 (d, J = 2.1 Hz, 1 H), 7.87 (d, J = 5.0 Hz, 2H), 7.18 (d, J = 5.0 Hz, 1 H), 4.49 (dd, J =49.2, 8.8 Hz, 1H), 4.00 (dd, J =36.3, 14.9 Hz, 1H), 3.55 (td, J = 15.4, 9.3 Hz, 1H), 1.34- 1.29 (m, 6H). compound 1H-NMR
375 1H NMR (400 MHz, Methanol-d4) δ 9.76 (s, 1H), 8.84 (s, 1H), 8.67 (d, J = 13.5 Hz,
2H), 7.91 (d, J = 4.9 Hz, 1 H), 7.59 (d, J = 3.8 Hz, 1 H), 7.27 (d, J = 3.7 Hz, 1 H), 7.17 (d, J = 5.0 Hz, 1H), 4.48 (ddd, J =49.0, 9.2, 2.2 Hz, 1H), 3.99 (ddd, J = 35.8, 14.5, 2.2 Hz, 1H), 3.65-3.48 (m, 1H), 1.31 (d, J = 1.7 Hz, 6H).
376 1 H NMR (400 MHz, Methanol-d4) δ 8.86 (s, 1 H), 8.75 - 8.66 (m, 1 H), 7.96 (d, J =
4.9 Hz, 1H), 7.46 (d, J = 2.4 Hz, 1H), 7.22 (d, J =5.0 Hz, 1H), 7.12 (dd, J = 8.8, 2.6 Hz, 1H), 4.41 (s, OH), 3.98 (s,
OH), 3.88 (s, 3H), 1.32 (d, J = 1.6 Hz, 6H). Poor solubility resulted in poor signal to noise. Not all peaks indentified.
377 1H NMR (400 MHz, Methanol-d4) δ 8.85 (s, 1H), 8.66 (d, J = 10.4 Hz, 2H), 7.93 (d,
J = 5.0 Hz, 1 H), 7.85 (d, J = 7.9 Hz, 1 H), 7.50 (t, J = 7.7 Hz, 1 H), 7.35 (t, J = 7.7 Hz, 1H), 7.17 (d, J = 5.0 Hz, 1H), 4.49 (ddd, J =49.0, 9.3, 2.2 Hz, 1H), 3.99 (dd, J = 36.0, 14.6 Hz, 1H), 3.58 (dd, J = 15.3, 9.4 Hz, 1H), 1.32 (d, J = 1.6 Hz, 6H).
378 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.74 (d, J = 2.2 Hz,
1 H), 8.63 (s, 1 H), 8.35 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.41 (ddd, J =49.1, 9.3, 2.1 Hz, 1H), 3.92 (ddd, J =36.5, 14.6, 2.1 Hz, 1H), 3.47 (ddd, J = 16.2, 14.5, 9.4 Hz, 1H), 2.85 (s, 6H), 1.28 (d, J = 1.6 Hz, 6H).
379 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.51 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.76 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 3.93 (ddd, J =36.4, 14.5, 2.2 Hz, 1H), 3.48 (ddd, J = 16.2, 14.5, 9.4 Hz, 1H), 3.19 (s, 3H), 1.28 (d, J = 1.7 Hz, 6H).
380 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.53 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.85 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.14 (p, J = 6.5 Hz, 1H), 2.65 (s, 6H), 1.39 (d, J =6.4 Hz, 6H).
381 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 1 H), 8.69 (d, J = 2.2 Hz, 1 H), 8.60 (d,
J = 2.2 Hz, 1 H), 8.53 (s, 1 H), 8.06 (d, J = 8.5 Hz, 2H), 7.84 (d, J = 4.9 Hz, 1 H), 7.58 (d, J = 8.5 Hz, 2H), 7.15 (d, J =5.0 Hz, 1H), 4.47 (dd, J =49.1, 7.4 Hz, 1H), 3.98 (dd, J =36.2, 15.1 Hz, 1H), 3.76-3.35 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
382 1 H NMR (400 MHz, Methanol-d4) δ 8.67 (s, 1 H), 8.62 (d, J = 2.2 Hz, 1 H), 8.44 (d,
J = 2.2 Hz, 1 H), 8.34 (s, 1 H), 7.83 - 7.59 (m, 4H), 7.45 - 7.36 (m, 1 H), 7.11 (d, J = 5.0 Hz, 1 H), 4.48 (ddd, J = 49.0, 9.3, 2.2 Hz, 1 H), 4.13 - 3.85 (m, 1 H), 3.61 - 3.39 (m, 1H), 1.30 (d, J = 1.8 Hz, 6H).
383 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (s, 1 H), 8.66 (d, J = 2.2 Hz, 1 H), 8.50 (d,
J = 2.2 Hz, 1 H), 8.32 (s, 1 H), 8.05 (t, J = 1.9 Hz, 1 H), 7.88 (dt, J = 7.7, 1.4 Hz, 1 H), 7.79 (d, J = 5.1 Hz, 1 H), 7.66 (t, J = 7.8 Hz, 1 H), 7.60 (ddd, J = 8.0, 2.3, 1.2 Hz, 1H), 7.13 (d, J =5.1 Hz, 1H), 4.47 (ddd, J = 49.1, 9.3, 2.1 Hz, 1H), 3.99 (ddd, J = 36.4, 14.6, 2.1 Hz, 1H), 3.53 (ddd, J = 16.1, 14.6, 9.3 Hz,
1H), 1.30 (d, J = 1.6 Hz, 6H).
384 1H NMR (400 MHz, DMSO-d6) δ 10.49 (s, 1H), 8.97 (t, J = 5.7 Hz, 1H), 8.91 -8.73
(m, 2H), 8.68 (s, 1 H), 8.54 (d, J = 2.2 Hz, 1 H), 7.83 (d, J = 4.8 Hz, 1 H), 7.51 (td, J = 8.2,6.7 Hz, 1H), 7.35-7.17
(m, 2H), 7.09 (d, J = 4.8 Hz, 1 H), 6.97 (td, J = 8.7, 2.0 Hz, 1 H), 4.38 (ddd, J = 49.2, 9.3, 2.1 Hz, 1 H), 3.90 - 3.61 (m, 1 H), 3.54 - 3.35 (m, 1 H), 1.30 - 1.02 (m, 6H).
385 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (s, 1 H), 8.68 (d, J = 2.2 Hz, 1 H), 8.62 (d,
J =2.2 Hz, 1H), 8.35 (s, 1H), 7.87 (d, J =5.0 Hz, 1H), 7.76-7.54 (m, 6H), 7.15 (d, J = 5.0 Hz, 1 H), 6.70 (d, J = 9.1 Hz, 1 H), 6.54 (td, J = 6.7, 1.3 Hz, 1 H), 4.48 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.20 - 3.87 (m, 1 H), 3.67 - 3.40 (m, 1 H), 1.31 (d, J = 1.6 Hz, 6H).
386 1 H NMR (400 MHz, Methanol-d4) δ 8.80 (s, 1 H), 8.77 (d, J = 2.2 Hz, 1 H), 8.75 (dd,
J = 2.3, 0.9 Hz, 1 H), 8.68 (d, J = 2.2 Hz, 1 H), 8.38 (dd, J = 8.8, 0.9 Hz, 1 H), 8.20 (dd, J = 8.8, 2.3 Hz, 1 H), 8.06 (d, J = 5.1 Hz, 1 H), 8.01 (s, 1 H), 7.23 (d, J = 5.1 Hz, 1H), 4.27 (dt, J = 9.6, 5.3 Hz, 1H), 4.14 (s, 1H), 2.18-1.84 (m, 2H), 1.83- 1.68 (m, 4H), 1.46- 1.23 (m, 2H).
387 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.22 (dt, J =9.1, 4.9 Hz, 1H), 4.10 (s, 1H), 3.84 (d, J = 11.6 Hz, 1H), 3.62 (s, 3H), 3.47-3.35 (m, 1H), 2.15- 1.84 (m, 7H), 1.83-1.21 (m, 9H).
388 1 H NMR (400 MHz, Methanol-d4) δ 8.77 - 8.64 (m, 1 H), 8.59 (dq, J = 9.6, 2.0, 1.6
Hz, 2H), 8.07-7.87 (m, 1H), 7.77 (t, J = 1.4 Hz, 1H), 7.16 (dt, J =5.1, 1.4 Hz, 1H), 4.30 (t, J = 1.4 Hz, 2H), 3.89
(q, J =7.6 Hz, 1H), 2.75 (ddd, J = 12.3, 7.4, 2.3 Hz, 2H), 2.24 (t, J =9.5 Hz, 2H), 1.46 (s, 3H).
389 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.62 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.80 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.53-4.41 (m, 1H), 4.38 (s, 2H), 2.80-2.62 (m, 2H), 2.27-2.14 (m, 2H), 1.44 (s, 3H).
390 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.89 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), compound 1H-NMR
4.48 - 4.28 (m, 2H), 4.06 (s, 2H), 3.85 (tt, J = 11.4, 4.0 Hz, 1 H), 3.74 - 3.59 (m, 3H), 2.26 (d, J = 12.5 Hz, 2H), 1.94 (d, J = 12.3 Hz, 2H), 1.82 (td, J = 12.6, 3.4 Hz, 2H), 1.63 (qd, J = 12.8, 3.6 Hz, 2H).
391 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.93 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.45-4.30 (m, 5H), 3.97-3.59 (m, 4H), 2.28 (d, J = 12.6 Hz, 2H), 1.96 (d, J = 11.9 Hz, 2H), 1.84 (qd, J = 12.8, 3.4 Hz, 2H), 1.74- 1.56 (m, 2H).
392 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.1 Hz,
1 H), 8.57 (s, 1 H), 8.03 (d, J = 5.0 Hz, 1 H), 7.89 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.54-4.28 (m, 3H), 4.01 - 3.59 (m, 5H), 3.55-3.39 (m, 1H), 2.27 (d, J = 12.6 Hz, 2H), 2.02-1.91 (m, 2H), 1.82 (td, J = 12.6, 3.3 Hz, 2H), 1.69 -1.50 (m, 2H), 1.29 (d, J = 1.7 Hz, 6H).
393 1 H NMR (400 MHz, Methanol-d4) δ 8.82 - 8.68 (m, 2H), 8.54 (s, 1 H), 8.30 (s, 1 H),
7.94 (d, J = 5.1 Hz, 1H), 7.22 (d, J =5.1 Hz, 1H), 6.12 (td, J =56.3,3.7 Hz, 1H), 4.61 (s, 1 H), 4.40 (ddd, J = 49.1 , 9.2, 1.9 Hz, 2H), 4.06 (s, 1 H), 3.91 (ddd, J = 36.5, 14.9, 2.1 Hz, 2H), 3.57-3.39 (m, 1H), 3.10 (ddd, J = 15.5, 7.7, 4.7 Hz, 1H), 2.26 - 2.12 (m, 6H), 2.07 (dd, J = 9.9, 4.6 Hz, 6H), 1.28 (d, J = 1.6 Hz, 6H).
394 1 H NMR (400 MHz, Methanol-d4) δ 8.88 - 8.63 (m, 2H), 8.54 (s, 1 H), 8.32 (s, 1 H),
7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.71 - 4.19 (m, 3H), 4.25 - 3.9(m, 2H), 3.91 (dd, J =36.8, 14.2 Hz, 1H), 3.47 (td, J = 15.5, 9.3 Hz, 1H), 2.16 (d, J = 7.8 Hz, 6H), 2.08 (d, J = 7.6 Hz, 6H), 1.62 (d, J = 21.5 Hz, 3H), 1.28 (d, J = 1.7 Hz, 6H).
395 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.25 (s, 1 H), 7.94 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 6.92 (d, J = 4.6 Hz, 1 H), 4.83 - 4.74 (m, 3H), 4.40 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.21 (t, J =6.4 Hz, 1H), 4.03-3.76 (m, 4H), 3.48 (ddd, J = 16.0, 14.6, 9.4 Hz, 1H), 3.13 - 2.96 (m, 4H), 2.29 - 2.01 (m, 12H), 1.28 (d, J = 1.7 Hz, 6H).
396 1 H NMR (400 MHz, Methanol-d4) δ 8.82 - 8.67 (m, 2H), 8.54 (s, 1 H), 8.32 (s, 1 H),
7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.68 (s, 1 H), 4.40 (ddd, J = 49.0, 9.5, 2.1 Hz, 1H), 4.29 (s, 1H),
4.22 (td, J =6.4, 3.4 Hz, 1H), 4.13 (s, 1H), 3.91 (ddd, J = 36.6, 14.5, 2.0 Hz, 1H), 3.79 (s, 1H), 3.47 (td, J = 15.3, 9.3 Hz, 1H), 2.15 (d, J =7.9 Hz, 6H), 2.08 (d, J = 7.8 Hz, 6H), 1.28 (d, J = 1.
7 Hz, 6H).
397 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (s, 2H), 8.54 (s, 1 H), 8.44 (s, 1 H), 7.93 (d,
J = 5.1 Hz, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.40 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 3.91 (ddd, J =36.7, 14.5, 2.1 Hz,
1H), 3.53-3.36 (m, 5H), 3.35 (s, 3H), 2.18 (dd, J = 10.3, 5.3 Hz, 6H), 2.03 (dd, J = 10.2, 5.4 Hz, 6H), 1.28 (d, J = 1.6 Hz, 6H).
398 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (q, J = 2.2 Hz, 2H), 8.54 (s, 1 H), 8.45 (s,
1H), 7.92 (d, J =5.1 Hz, 1H), 7.22 (d, J =5.1 Hz, 1H), 4.53-4.29 (m, 1H), 4.10- 3.82 (m, 1H), 3.65-3.36 (m, 1H), 2.18 (dd, J = 10.2, 5.3 Hz, 6H), 2.05 (dd, J = 10.1, 5.4 Hz, 6H), 1.28 (d, J = 1.6 Hz, 6H).
399 1 H NMR (400 MHz, Chloroform-d) δ 8.38 (d, J = 0.9 Hz, 1 H), 8.32 - 8.25 (m, 2H),
8.19 (dd, J = 2.3, 0.9 Hz, 1 H), 7.73 (dd, J = 4.8, 1.0 Hz, 1 H), 6.93 (dd, J = 4.8, 0.9 Hz, 1H), 4.46-4.24 (m, 1H), 4.19 (dd, J = 8.9, 6.8 Hz, 2H), 3.85 (ddd, J =30.8, 14.6, 3.0 Hz, 1H), 3.61 -3.56 (m, 2H), 3.48-3.40 (m, 1H), 2.11 (s, 12H), 1.28 - 1.19 (m, 6H).
400 1 H NMR (400 MHz, Methanol-d4) δ 8.80 - 8.67 (m, 2H), 8.54 (s, 1 H), 8.32 (s, 1 H),
7.94 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 5.33 (dtd, J = 60.4, 6.1,3.1 Hz, 1H), 4.40 (ddd, J = 49.1, 9.3, 2.1 Hz, 1H), 3.91 (ddd, J =36.5, 14.5, 2.1 Hz, 1H), 3.47 (td, J = 15.4, 9.4 Hz, 1H), 2.24-2.14 (m, 6H), 2.08 (d, J = 7.7 Hz, 6H), 1.28 (d, J = 1.6 Hz, 6H).
401 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 8.23 (s, 1 H), 8.01 - 7.92 (m, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.53 - 4.28 (m, 1 H), 4.03 - 3.78 (m, 1 H), 3.70 (s, 4H), 3.68 - 3.61 (m, 4H), 3.59 - 3.39 (m, 1H), 2.17 (s, 12H), 1.28 (d, J = 1.6 Hz, 6H).
402 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.46 (s, 1 H), 8.24 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 2.32-2.08 (m, 12H), 1.97 - 1.83 (m, 6H), 1.83- 1.67 (m, 6H).
403 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (s, 1 H), 8.76 (d, J = 2.2 Hz, 1 H), 8.57 (s,
1 H), 8.41 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 3.92 (ddd, J = 36.6, 14.6, 2.1 Hz, 1 H), 3.60 - 3.38 (m, 1 H), 2.20 (t, J =7.7 Hz, 4H), 2.13 (s, 2H), 2.05- 1.80 (m, 4H), 1.28 (d, J = 1.6 Hz, 6H).
404 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 8.28 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.40 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 3.91 (ddd, J =36.6, 14.6, 2.1 Hz, 1H), 3.59 - 3.40 (m, 1H), 2.18 (s, 12H), 1.28 (d, J = 1.7 Hz, 6H). compound 1 H-NMR
405 1 H NMR (400 MHz, Methanol-d4) δ 8.85 - 8.69 (m, 2H), 8.54 (s, 1 H), 8.35 (s, 1 H),
7.93 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.40 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 3.91 (ddd, J = 36.5, 14.5, 2.1 Hz, 1 H), 3.46 (ddd, J = 15.7, 14.6, 9.4 Hz, 1 H), 2.79 (t, J = 4.0 Hz, 2H), 2.19 (dt, J = 24.1 , 6.2 Hz, 12H), 1 .28 (d, J = 1 .7 Hz, 6H).
406 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (s, 2H), 8.55 (s, 1 H), 8.43 (s, 1 H), 7.93 (d,
J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.40 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.06 - 3.79 (m, 1 H), 3.62 - 3.37 (m, 1 H), 2.62 (tt, J = 7.4, 3.9 Hz, 1 H), 2.16 (dd, J = 10.3, 5.4 Hz, 6H), 2.00 (dd, J = 10.1 , 5.4 Hz, 6H), 1.28 (d, J = 1.6 Hz, 6H), 0.79 - 0.66 (m, 2H), 0.58 - 0.42 (m, 2H).
407 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (s, 2H), 8.54 (s, 1 H), 8.44 (s, 1 H), 7.92 (d,
J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.40 (ddd, J = 49.2, 9.4, 2.1 Hz, 1 H), 4.06 - 3.77 (m, 1 H), 3.59 - 3.39 (m, 1 H), 3.22 (q, J = 7.2 Hz, 2H), 2.17 (dd, J = 10.2, 5.5 Hz, 6H), 2.02 (dd, J = 10.0, 5.6 Hz, 6H), 1.28 (d, J = 1 .6 Hz, 6H), 1.11 (t, J = 7.2 Hz, 3H).
408 1 H NMR (400 MHz, Methanol-d4) δ 8.81 - 8.65 (m, 2H), 8.54 (s, 1 H), 8.33 (s, 1 H),
7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.52 (d, J = 8.0 Hz, 2H), 4.47 - 4.25 (m, 1 H), 4.08 - 3.78 (m, 3H), 3.58 - 3.38 (m, 1 H), 2.30 (p, J = 7.8 Hz, 2H), 2.22 - 2.12 (m, 6H), 2.08 (d, J = 7.6 Hz, 6H), 1.28 (d, J = 1.7 Hz, 6H).
409 1 H NMR (400 MHz, Methanol-d4) δ 8.80 - 8.68 (m, 2H), 8.54 (s, 1 H), 8.32 (s, 1 H),
7.94 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.40 (ddd, J = 49.1 , 9.4, 2.0 Hz, 1 H), 4.03 - 3.76 (m, 1 H), 3.55 -
3.39 (m, 1 H), 2.24 - 2.13 (m, 6H), 2.11 - 2.01 (m, 6H), 1.28 (d, J = 1.6 Hz, 6H).
410 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (t, J = 1.9 Hz, 2H), 8.54 (s, 1 H), 8.44 (s,
1 H), 7.92 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.40 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.01 - 3.81 (m, 1 H), 3.46 (td, J = 15.4, 9.5 Hz, 1 H), 2.42 (s, 1 H), 2.16 (dd, J = 10.3, 5.4 Hz, 6H), 2.08 (s, 6H), 1.99 (dd, J = 10.0, 5.5 Hz, 6H), 1.28 (d, J = 1 .6 Hz, 6H).
411 1 H NMR (400 MHz, Methanol-d4) δ 8.82 - 8.70 (m, 2H), 8.54 (s, 1 H), 8.38 (s, 1 H),
7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.40 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 3.90 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.63 - 3.35 (m, 1 H), 2.87 (d, J = 7.0 Hz, 6H), 2.28 (s, 12H), 1.28 (d, J = 1.7 Hz, 6H).
412 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 2H), 8.55 (s, 1 H), 8.36 (s, 1 H), 7.94 (d,
J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.40 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 3.90 (ddd, J = 36.4, 14.6, 2.2 Hz,
1 H), 3.47 (ddd, J = 16.0, 14.5, 9.4 Hz, 1 H), 2.64 (s, 3H), 2.26 (s, 12H), 1.28 (d, J = 1 .7 Hz, 6H).
413 1 H NMR (400 MHz, Chloroform-d) δ 10.04 (d, J = 0.6 Hz, 1 H), 8.75 (d, J = 0.6 Hz,
1 H), 8.64 (dd, J = 2.3, 0.8 Hz, 1 H), 8.34 (d, J = 2.3 Hz, 1 H), 8.21 (d, J = 2.2 Hz, 1 H), 7.95 - 7.69 (m, 2H), 7.08 - 6.86 (m, 2H), 4.44 (ddd, J = 47.4, 7.3, 3.1 Hz, 1 H), 4.04 - 3.87 (m, 1 H), 3.55 (ddd, J = 21.0, 14.7, 7.3 Hz, 1 H), 1 .32 (dd, J = 11 .9, 1.6 Hz, 6H).
414 1 H NMR (400 MHz, Chloroform-d) δ 8.43 (d, J = 1.5 Hz, 1 H), 8.38 - 8.23 (m, 2H),
8.20 (d, J = 2.2 Hz, 1 H), 7.90 (dd, J = 4.9, 2.2 Hz, 1 H), 6.98 (d, J = 4.9 Hz, 1 H), 4.74 - 4.41 (m, 1 H), 4.13 - 3.91 (m, 1 H), 3.73 - 3.39 (m, 1 H), 2.30 - 2.1 1 (m, 6H), 1 .88 (dq, J = 7.5, 4.5, 4.0 Hz, 6H), 1.33 - 1.22 (m, 6H).
415 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 8.28 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.52 - 4.28 (m, 1 H), 3.91 (ddd, J =
36.5, 14.6, 2.1 Hz, 1 H), 3.54 - 3.41 (m, 1 H), 3.19 - 3.01 (m, 6H), 2.18 (s, 12H), 1 .28 (d, J = 1.6 Hz, 6H).
416 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (s, 2H), 8.54 (s, 1 H), 8.45 (s, 1 H), 7.93 (d,
J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.40 (dd, J = 48.7, 9.0 Hz, 1 H), 3.91 (dd, J = 36.5, 14.5 Hz, 1 H), 3.72 (p, J = 6.6 Hz, 1 H), 3.56 - 3.40 (m, 1 H), 2.73 (d, J = 3.8 Hz, 3H), 2.18 (t, J = 7.8 Hz, 6H), 2.02 (t, J = 7.4 Hz, 6H), 1.28 (d, J = 1.7 Hz, 6H).
417 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.72 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.31 (s, 1 H), 7.94 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.74 (dd, J = 9.4, 2.0 Hz, 1 H), 3.88 (ddd, J = 36.8, 14.6, 2.0 Hz, 1 H), 3.50 (ddd, J = 16.3, 14.6, 9.4 Hz, 1 H), 2.28 (s, 12H), 2.01 (s, 3H), 1.56 (d, J = 1.7 Hz, 6H).
418 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.72 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.30 (s, 1 H), 7.94 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.40 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 3.90 (ddd, J = 36.5, 14.5, 2.1 Hz, 1 H), 3.55 - 3.38 (m, 1 H), 2.28 (s, 12H), 1 .97 (s, 3H), 1.28 (d, J = 1.7 Hz, 6H).
419 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.71 - 8.55 (m, 2H),
7.98 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.43 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.09 - 3.84 (m,
2H), 3.50 (ddd, J = 15.9, 14.0, 9.4 Hz, 1 H), 2.39 (s, 2H), 2.21 (s, 1 H), 2.00 - 1.61 (m, 10H), 1 .29 (d, J = 1.6 Hz, 6H). compound 1 H-NMR
420 1 H NMR (400 MHz, Methanol-d4) δ 10.24 (s, 1 H), 9.08 (s, 2H), 8.90 (s, 1 H), 8.72
(dd, J = 13.8, 2.2 Hz, 2H), 7.98 (d, J = 5.0 Hz, 1 H), 7.19 (d, J = 5.0 Hz, 1 H), 4.47 (ddd, J = 49.0, 9.4, 2.2 Hz, 1 H), 4.11 - 3.89 (m, 1 H), 3.67 - 3.43 (m, 1 H), 1 .39 - 1 .20 (m, 6H).
421 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.51 (s, 1 H), 8.35 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.40 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 3.91 (ddd, J = 36.5, 14.5, 2.1 Hz, 1 H), 3.58 - 3.38 (m, 1 H), 2.09 (dd, J = 10.2, 5.6 Hz, 6H), 1.87 (dd, J = 9.3, 4.2 Hz, 6H), 1 .76 - 1 .64 (m, 1 H), 1.28 (d, J = 1.6 Hz, 6H).
422 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.88 (d, J = 13.1 Hz, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.54 - 4.28 (m, 1 H), 4.04 - 3.77 (m, 3H), 3.57 - 3.36 (m, 1 H), 2.24 (d, J = 11 .8 Hz, 2H), 2.06 (d, J = 12.1 Hz, 2H), 1.76 - 1.51 (m, 4H), 1 .35 - 1.24 (m, 10H).
423 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.04 - 3.68 (m, 3H), 3.47 (ddd, J = 16.1 , 14.5, 9.4 Hz, 1 H), 2.22 (d, J = 10.4 Hz, 2H), 2.08 - 1 .93 (m, 2H), 1 .58 (q, J = 11.3 Hz, 4H), 1.33 (s, 3H), 1.28 (d, J = 1.7 Hz, 6H), 1.08 (q, J = 3.9 Hz, 2H), 0.60 (q, J = 3.9 Hz, 2H).
424 1 H NMR (400 MHz, Methanol-d4) δ 8.64 - 8.55 (m, 2H), 8.53 (d, J = 6.1 Hz, 2H),
7.82 (d, J = 4.9 Hz, 1 H), 7.08 (d, J = 4.9 Hz, 1 H), 6.38 - 6.26 (m, 1 H), 6.23 - 6.16 (m, 1 H), 5.91 - 5.77 (m, 1 H), 4.49 - 4.30 (m, 1 H), 3.95 - 3.77 (m, 1 H), 3.49 - 3.40 (m, 1 H), 2.18 (s, 13H), 1.28 (d, J = 1.6 Hz, 6H).
425 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.1 Hz,
1 H), 8.56 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.86 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 6.30 - 6.21 (m, 2H), 5.65 (dd, J = 7.5, 4.5 Hz, 1 H), 4.52 - 4.26 (m, 1 H), 4.11 - 3.68 (m, 3H), 3.58 - 3.39 (m, 1 H), 2.23 (d, J = 10.5 Hz, 2H), 2.09 (d, J = 10.3 Hz, 2H), 1 .58 (q, J = 11.4 Hz, 4H), 1.29 (d, J = 1 .7 Hz, 6H).
426 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.91 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.67 (td, J = 5.6, 3.1 Hz, 1 H), 4.23 (dq, J = 8.7, 4.4, 3.9 Hz, 1 H), 4.11 (s, 1 H), 2.94 - 2.87 (m, 1 H), 2.17 - 1.51 (m, 2H), 1 .84 - 1 .49 (m, 5H), 1.36 (dd, J = 6.8, 3.3 Hz, 1 H), 1.29 - 1.04 (m, 2H).
427 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.43 (td, J = 8.3, 5.0 Hz, 1 H), 4.21 (dt, J = 9.2, 4.9 Hz, 1 H), 4.09 (s, 1 H), 2.68 (t, J = 12.2 Hz, 2H), 2.56 (dt, J = 12.4, 9.9 Hz, 5H), 2.27 (td, J = 9.2, 3.0 Hz, 2H), 2.13 - 1 .83 (m, 3H), 1.83 - 1.48 (m, 4H).
428 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.93 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.23 (tt, J = 8.7, 3.8 Hz, 1 H), 4.10 (s, 1 H), 3.53 (s, 2H), 2.04 (td, J = 14.8, 13.6, 7.4 Hz, 2H), 1 .91 (dq, J = 9.9, 5.7 Hz, 1 H), 1.78 (ddd, J = 13.0, 9.2, 3.0 Hz, 1 H), 1 .69 (t, J = 5.5 Hz, 3H), 1.59 (td, J = 1 1.6, 10.6, 8.4 Hz, 1 H), 1.35 - 1.27 (m, 2H), 1 .22 - 1 .1 1 (m, 2H).
429 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.96 - 7.83 (m, 2H), 7.21 (d, J = 5.1 Hz, 1 H), 4.57 - 4.24 (m, 2H), 4.06 - 3.82 (m, 1 H), 3.48 (td, J = 15.4, 9.7 Hz, 1 H), 2.93 - 2.72 (m, 2H), 2.44 - 2.19 (m, 2H), 1.72 (s, 3H), 1.29 (d, J = 1 .7 Hz, 6H).
430 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.94 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.36 - 4.03 (m, 2H), 3.53 - 3.39 (m, 1 H), 2.09 - 1.85 (m, 4H), 1.70 (s, 3H), 1.60 (d, J = 1 1.2 Hz, 3H).
431 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.91 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.22 (dt, J = 9.1 , 4.9 Hz, 1 H), 4.10 (s, 1 H), 4.02 (d, J = 11.0 Hz, 1 H), 2.23 - 1.82 (m, 8H), 1.82 - 1.51 (m, 8H).
432 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.27 (s, 1 H), 7.91 (d, J = 5.0 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 3.92 (ddd, J = 36.6, 14.5, 2.1 Hz, 2H), 3.59 - 3.40 (m, 1 H), 2.05 (h, J = 11 .6, 10.8 Hz, 4H), 1.80 (d, J = 10.1 Hz, 1 H), 1 .72 - 1.65 (m, 1 H), 1.63 (s, 3H), 1.41 - 1.31 (m, 1 H), 1.28 (d, J = 1.6 Hz, 6H).
433 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.71 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.96 - 7.81 (m, 2H), 7.21 (d, J = 5.1 Hz, 1 H), 4.54 - 4.21 (m, 2H), 3.93 (ddd, J = 36.7, 14.5, 2.1 Hz, 1 H), 3.48 (ddd, J = 16.0, 14.5, 9.4 Hz, 1 H), 2.87 (ddd, J = 9.9, 7.2, 2.9 Hz, 2H), 2.41 - 2.15 (m, 2H), 1.61 (s, 3H), 1.28 (d, J = 1 .7 Hz, 6H).
434 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 1 H), 8.69 (d, J = 2.1 Hz, 1 H), 8.55 (d,
J = 2.1 Hz, 1 H), 8.33 (s, 1 H), 8.04 - 7.90 (m, 1 H), 7.82 (d, J = 5.0 Hz, 1 H), 7.68 (s, 1 H), 7.64 (d, J = 8.1 Hz, 1 H), 7.15 (d, J = 5.0 Hz, 1 H), 4.56 (s, 2H), 4.56 - 4.33 (m, compound 1H-NMR
1H), 4.16-3.79 (m, 1H), 3.65-3.42 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
435 1 H NMR (400 MHz, Methanol-d4) δ 8.67 (d, J = 2.2 Hz, 1 H), 8.57 (d, J = 2.2 Hz,
1 H), 8.23 (s, 1 H), 7.75 (d, J = 5.0 Hz, 2H), 7.43 (s, 1 H), 7.27 (s, 1 H), 7.20 - 7.06 (m, 2H), 4.54 (ddd, J = 62.2, 43.4,
11.9 Hz, 2H), 4.14 -3.94 (m, 1H), 1.25 (s, 6H).
436 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.03 (d, J = 5.0 Hz, 1 H), 7.86 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.41 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 4.03-3.60 (m, 3H), 3.59-3.38 (m, 1H), 2.18 (d, J =7.1 Hz, 2H), 2.04 (dd, J = 9.7, 4.3 Hz, 2H), 1.65-1.41 (m, 4H), 1.28 (d, J = 1.7 Hz, 6H).
437 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.86 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.05 - 3.80 (m, 3H), 3.56 - 3.39 (m, 1 H), 2.00 - 1.58 (m, 8H), 1.29 (d, J = 1.7 Hz, 6H).
438 1 H NMR (400 MHz, DMSO-d6) δ 7.93 (d, J = 2.2 Hz, 1 H), 7.87 (d, J = 2.2 Hz, 1 H),
7.74 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 7.04 (s, 1 H), 6.39 (d, J = 5.1 Hz, 1 H), 3.61 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 3.12 (ddd, J = 36.5, 14.5, 2.1 Hz, 1H), 2.82 (t, J = 6.6 Hz, 2H), 2.67 (ddd, J = 16.0, 14.5, 9.3 Hz, 1H), 2.44 (t, J =7.1 Hz, 2H), 2.17 (s, 3H), 1.30 - 1.04 (m, 4H), 0.47 (d, J = 1.7 Hz, 6H).
439 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.04 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.43 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 3.93 (ddd, J =36.4, 14.5, 2.1 Hz, 1H), 3.81 - 3.69 (m, 2H), 3.49 (ddd, J = 16.2, 14.5, 9.3 Hz, 1H), 3.26 (t, J =7.1 Hz, 2H), 3.16 (q, J =7.5 Hz, 2H), 2.35-2.18 (m, 2H), 1.37 (t, J =7.5 Hz, 3H), 1.28 (d, J = 1.7 Hz, 6H).
440 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.58 (d, J = 0.9 Hz, 1 H), 8.05 (d, J = 5.1 Hz, 1 H), 7.89 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.43 (ddt, J = 49.0, 9.3, 2.3 Hz, 1 H), 4.30 (q, J = 6.5 Hz, 1 H), 4.04 - 3.82 (m, 1 H), 3.63 - 3.40 (m, 1 H), 3.32 (d, J = 7.4 Hz, 2H), 3.07 - 3.00 (m, 3H), 2.29 (dd, J = 14.4, 7.1 Hz, 1H), 2.21 -2.07 (m, 1H), 1.45 (d, J = 6.4 Hz, 3H), 1.29 (d, J = 1.6 Hz, 6H).
441 1 H NMR (400 MHz, Methanol-d4) δ 8.81 - 8.66 (m, 2H), 8.58 (d, J = 2.2 Hz, 1 H),
7.97-7.78 (m, 3H), 7.63 (dd, J = 9.6, 2.9 Hz, 1H), 7.16 (d, J =5.1 Hz, 1H), 6.72 (d, J =9.6 Hz, 1H), 4.45 (ddd, J =49.1, 9.3, 2.1 Hz, 1H), 3.97 (ddd, J =36.5, 14.6, 2.1 Hz, 1 H), 3.62 (s, 3H), 3.59 - 3.44 (m, 1 H), 1.29 (d, J = 1.7 Hz, 6H).
442 1 H NMR (400 MHz, Methanol-d4) δ 8.80 (s, 1 H), 8.76 (s, 1 H), 8.69 (s, 2H), 7.91 (d,
J =5.0 Hz, 1H), 7.76 (d, J =7.3 Hz, 1H), 7.17 (d, J = 5.0 Hz, 1H), 6.71 (d, J =2.5 Hz, 1 H), 6.45 (dd, J = 7.3, 2.5 Hz, 1 H), 4.45 (ddd, J = 49.0, 9.2, 2.1 Hz, 1 H), 3.97 (ddd, J =36.4, 14.5, 2.2 Hz, 1H), 3.60 (s, 3H), 3.57-3.43 (m, 1H), 1.29 (d, J = 1.6 Hz, 6H).
443 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.1 Hz,
1 H), 8.60 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.76 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.68-4.27 (m, 2H), 4.15-3.73 (m, 2H), 3.50 (ddd, J = 16.1, 14.6, 9.3 Hz, 1H), 3.24 - 3.03 (m, 2H), 3.01 (s, 3H), 2.76 - 2.50 (m, 2H), 1.29 (d, J = 1.7 Hz, 6H).
444 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.53 (s, 1 H), 8.28 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.40 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 3.90 (ddd, J =36.7, 14.6, 2.1 Hz, 1H), 3.46 (ddd, J = 15.9, 14.5, 9.4 Hz, 1H), 2.25 (dd, J = 10.2, 5.8 Hz, 6H), 1.95- 1.84 (m, 6H), 1.28 (d, J = 1.6 Hz, 6H).
445 1 H NMR (400 MHz, Methanol-d4) δ 8.68 (d, J = 2.2 Hz, 1 H), 8.60 (d, J = 2.2 Hz,
1H), 8.56 (s, 1H), 7.95 (d, J = 5.0 Hz, 1H), 7.89 (s, 1H), 7.16 (d, J =5.0 Hz, 1H), 4.43 (ddd, J =49.1, 9.3, 2.2 Hz, 1H), 4.13-3.78 (m, 2H), 3.50 (ddd, J = 16.0, 14.5, 9.3 Hz, 1H), 2.15 (d, J = 10.6 Hz, 2H), 1.77 -1.48 (m, 6H), 1.29 (d, J = 1.6 Hz, 9H).
446 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.75 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.55 - 4.30 (m, 2H), 3.94 (ddd, J =
36.6, 14.6, 2.1 Hz, 1H), 3.49 (ddd, J = 16.0, 14.5, 9.4 Hz, 1H), 2.81 -2.58 (m, 2H), 2.31 - 2.11 (m, 2H), 1.44 (s, 3H), 1.29 (d, J = 1.6 Hz, 6H).
447 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (dd, J = 2.2, 0.9 Hz, 1 H), 8.70 (dd, J =
4.8, 2.2 Hz, 1 H), 8.58 (s, 1 H), 8.00 (dd, J = 6.5, 5.1 Hz, 1 H), 7.73 (d, J = 5.6 Hz, 1H), 7.21 (d, J =5.0 Hz, 1H), 4.58-4.25 (m, 3H), 4.21 (s, 1H), 4.14 (s, 1H), 4.05 - 3.83 (m, 2H), 3.59 - 3.39 (m, 1 H), 2.99 - 2.81 (m, 2H), 2.40 (dd, J = 12.2, 8.8 Hz, 2H), 1.92 - 1.81 (m, 3H), 1.29 (d, J = 1.8 Hz, 6H).
448 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.70 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.55-4.17 (m, 2H), 4.09 (s, 2H), 4.03-3.79 (m, 3H), 3.61 -3.38 (m, 1H), 2.87 (ddd, J = 10.3, 7.5, 3.0 Hz, 2H), 2.52-2.24 (m, 2H), 1.44 (s, 9H), 1.29 (d, J = 1.7 Hz, 6H). compound 1 H-NMR
449 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.71 (d, J = 2.2 Hz,
1 H), 8.64 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.71 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.82 - 4.67 (m, 2H), 4.58 - 4.26 (m, 3H), 4.08 - 3.83 (m, 2H), 3.60 - 3.41 (m, 1 H), 1 .93 (s, 3H), 1 .29 (d, J = 1.7 Hz, 6H).
450 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.1 Hz,
1 H), 8.58 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.70 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.06 - 3.81 (m, 2H), 3.62 - 3.42 (m, 1 H), 2.76 (ddt, J = 9.6, 7.3, 2.5 Hz, 2H), 2.19 (ddd, J = 10.5, 8.0, 2.8 Hz, 2H), 1.46 (s, 3H), 1 .29 (d, J = 1.7 Hz, 6H).
451 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (s, 1 H), 8.72 (d, J = 2.1 Hz, 1 H), 8.60 (d,
J = 2.1 Hz, 1 H), 8.37 (s, 1 H), 8.02 (d, J = 8.6 Hz, 2H), 7.82 (d, J = 5.0 Hz, 1 H), 7.60 (d, J = 8.5 Hz, 2H), 7.17 (d, J = 5.1 Hz, 1 H), 4.43 (s, 2H), 2.97 (s, 3H).
452 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.72 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.37 (s, 2H), 4.29 (p, J = 7.7 Hz, 1 H), 2.87 - 2.62 (m, 2H), 2.41 - 2.25 (m, 2H), 2.24 - 2.09 (m, 4H), 1.33 (s, 3H).
453 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.04 - 7.95 (m, 1 H), 7.72 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.36 (s, 2H), 4.29 (p, J = 7.7 Hz, 1 H), 4.22 - 4.10 (m, 1 H), 2.80 - 2.50 (m, 3H), 2.37 (dt, J = 1 1.9, 6.2 Hz, 1 H), 2.18 (dd, J = 11.5, 7.8 Hz, 2H), 2.13 - 1.93 (m, 2H).
454 1 H NMR (400 MHz, Methanol-d4) δ 8.64 (d, J = 2.2 Hz, 1 H), 8.63 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 7.86 (d, J = 4.7 Hz, 1 H), 7.13 (d, J = 4.7 Hz, 1 H), 4.86 - 4.79 (m, 2H), 4.68 - 4.54 (m, 2H), 4.38 - 4.19 (m, 3H), 2.24 - 2.12 (m, 6H), 2.08 - 1.94 (m, 6H).
455 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.1 Hz,
1 H), 8.59 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.65 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.58 - 4.34 (m, 2H), 4.34 - 4.22 (m, 1 H), 4.09 - 3.85 (m, 1 H), 3.65 (s, 3H), 3.58 - 3.43 (m, 1 H), 2.74 - 2.57 (m, 2H), 2.57 - 2.45 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
456 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.1 Hz,
1 H), 8.59 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.64 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.55 - 4.32 (m, 3H), 4.10 - 3.85 (m, 1 H), 3.57 - 3.40 (m, 1 H), 2.71 - 2.46 (m, 4H), 1 .97 (s, 3H), 1 .29 (d, J = 1.6 Hz, 6H).
457 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.78 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.2, 9.4, 2.1 Hz, 1 H), 4.19 - 3.83 (m, 3H), 3.77 - 3.59 (m, 3H), 3.56 - 3.41 (m, 1 H), 3.07 - 2.93 (m, 2H), 2.17 - 2.01 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
458 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.79 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.26 - 4.06 (m, 2H), 4.05 - 3.83 (m, 1 H), 3.63 - 3.40 (m, 1 H), 3.1 1 - 2.97 (m, 2H), 2.16 - 2.00 (m, 2H), 1.93 (s, 3H), 1 .29 (d, J = 1 .7 Hz, 6H).
459 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.96 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.36 (s, 2H), 4.30 - 4.18 (m, 1 H), 4.16 - 4.05 (m, 1 H), 2.21 - 1.98 (m, 2H), 1.98 - 1 .84 (m, 1 H), 1.84 - 1.75 (m, 1 H), 1.75 - 1.53 (m, 4H).
460 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.64 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.65 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 5.22 - 5.06 (m, 3H), 4.76 (d, J = 3.4 Hz, 2H), 4.39 (s, 2H).
461 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.30 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.35 (s, 2H), 2.89 (dq, J = 7.0, 3.6 Hz, 1 H), 1 .16 - 1.06 (m, 2H), 0.89 - 0.75 (m, 2H).
462 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.88 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.36 (s, 2H), 4.26 - 4.08 (m, 1 H), 1.41 (d, J = 6.4 Hz, 6H).
463 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.81 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.36 (s, 2H), 3.20 (s, 3H).
464 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 8.04 (d, J = 5.1 Hz, 1 H), 7.93 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.37 - 4.24 (m, 1 H), 2.94 (s, 3H), 2.73 (s, 3H), 2.65 - 2.53 (m, 1 H), 2.19 - 2.07 (m, 1 H), 1.97 - 1.59 (m, 7H).
465 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.46 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.82 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.39 - 4.26 (m, 1 H), 2.93 (s, 3H), 2.91 - 2.83 (m, 1 H), 2.73 (s, 3H), 2.53 - 2.36 (m, 1 H), 2.29 - 2.17 (m, 1 H), 2.12 - 2.02 (m, 1 H), 2.02 - 1.80 (m, 3H).
466 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.51 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.92 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), compound 1 H-NMR
4.52 - 4.32 (m, 1 H), 3.02 - 2.93 (m, 1 H), 2.92 (s, 3H), 2.75 (s, 3H), 2.52 - 2.31 (m, 2H), 2.22 - 2.05 (m, 1 H), 1.97 - 1 .83 (m, 2H), 1.84 - 1.67 (m, 1 H).
467 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.1 Hz,
1 H), 8.51 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.92 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.48 - 4.34 (m, 1 H), 3.02 - 2.93 (m, 1 H), 2.92 (s, 3H), 2.75 (s, 3H), 2.52 - 2.31 (m, 2H), 2.23 - 2.06 (m, 1 H), 1.99 - 1 .83 (m, 2H), 1.83 - 1.67 (m, 1 H).
468 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.72 (d, J = 2.1 Hz,
1 H), 8.52 (s, 1 H), 8.29 (s, 1 H), 7.92 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 2.92 (s, 3H), 2.77 (s, 3H), 2.31 - 2.08 (m, 8H), 2.00 - 1.90 (m, 2H).
469 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.46 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.82 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.41 - 4.26 (m, 1 H), 2.93 (s, 3H), 2.92 - 2.85 (m, 1 H), 2.73 (s, 3H), 2.45 (dt, J = 14.7, 7.7 Hz, 1 H), 2.28 - 2.16 (m, 1 H), 2.12 - 2.03 (m, 1 H), 2.02 - 1.81 (m, 3H).
470 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.50 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.85 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 3.95 - 3.80 (m, 1 H), 2.92 (s, 3H), 2.72 (s, 3H), 2.53 - 2.38 (m, 1 H), 2.31 - 2.12 (m, 2H), 2.05 - 1.83 (m, 2H), 1.69 - 1 .33 (m, 4H).
471 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.51 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.73 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.67 - 4.49 (m, 1 H), 3.20 - 3.06 (m, 1 H), 2.93 (s, 3H), 2.85 - 2.69 (m, 2H), 2.78 (s, 3H), 2.50 - 2.33 (m, 2H).
472 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.50 (s, 1 H), 7.97 (d, J = 5.1 Hz, 1 H), 7.74 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.33 (p, J = 8.0 Hz, 1 H), 3.02 - 2.94 (m, 1 H), 2.93 (s, 3H), 2.88 - 2.76 (m, 2H), 2.73 (s, 3H), 2.42 - 2.24 (m, 2H).
473 1 H NMR (400 MHz, Methanol-d4) δ 8.82 (d, J = 2.2 Hz, 1 H), 8.75 (d, J = 2.2 Hz,
1 H), 8.50 (s, 1 H), 8.45 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 2.91 (s, 3H), 2.43 (s, 2H), 2.33 - 2.06 (m, 6H), 1.96 (s, 3H), 1.94 - 1.87 (m, 2H).
474 1 H NMR (400 MHz, Methanol-d4) δ 8.81 - 8.71 (m, 2H), 8.56 (s, 1 H), 8.37 (s, 1 H),
7.94 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.34 (s, 2H), 2.26 - 2.14 (m, 6H), 2.14 - 2.01 (m, 6H).
475 1 H NMR (400 MHz, Methanol-d4) δ 8.81 - 8.73 (m, 2H), 8.56 (s, 1 H), 8.51 (s, 1 H),
7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.34 (s, 2H), 2.73 (s, 3H), 2.26 - 2.13 (m, 6H), 2.09 - 1.95 (m, 6H).
476 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.74 (d, J = 2.1 Hz,
1 H), 8.56 (s, 1 H), 8.40 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.34 (s, 2H), 2.28 - 2.20 (m, 6H), 2.20 - 2.12 (m, 6H), 1.89 (s, 3H).
477 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.77 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.56 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 3.97 - 3.81 (m, 1 H), 3.75 - 3.54 (m, 8H), 2.65 (s, 6H), 2.65 (m, 1 H), 2.09 (d, J = 12.2 Hz, 2H), 1 .97 (s, 3H), 1.90 - 1.78 (m, 2H), 1.75 - 1.55 (m, 2H), 1.53 - 1 .36 (m, 2H).
478 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.77 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.56 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.64 (t, J = 11.9 Hz, 2H), 4.31 (t,
J = 12.2 Hz, 2H), 4.01 - 3.80 (m, 1 H), 2.65 (s, 6H), 2.42 - 2.26 (m, 1 H), 2.09 (d, J = 12.3 Hz, 2H), 1 .97 (s, 3H), 1.91 (d, J = 14.8 Hz, 2H), 1 .71 - 1 .52 (m, 2H), 1.49 - 1 .36 (m, 2H).
479 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.77 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.56 (s, 1 H), 7.95 (d, J = 5.2 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 3.97 - 3.79 (m, 1 H), 2.71 (s, 3H), 2.65 (s, 6H), 2.26 - 2.13 (m, 1 H), 2.09 (d, J = 12.2 Hz, 2H), 1 .97 (s, 3H), 1.92 (d, J = 13.0 Hz, 2H), 1 .73 - 1 .54 (m, 2H), 1.50 - 1.31 (m, 2H).
480 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.76 (m, 1 H), 8.74 (d, J = 2.1 Hz, 1 H),
8.55 (s, 1 H), 8.53 (s, 1 H), 7.93 (d, J = 5.0 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 2.92 (s, 3H), 2.64 (s, 6H), 1.62 - 1.50 (m, 1 H), 0.94 - 0.85 (m, 2H), 0.85 - 0.75 (m, 2H).
481 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.72 (m, 2H), 8.48 (s, 1 H), 8.40 (s, 1 H),
7.91 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 2.90 (s, 3H), 2.69 - 2.55 (m, 1 H), 2.22 - 2.09 (m, 6H), 2.09 - 1.94 (m, 6H), 0.79 - 0.67 (m, 2H), 0.55 - 0.45 (m, 2H).
482 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.47 (s, 1 H), 8.33 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 2.90 (s, 3H), 2.30 - 2.08 (m, 12H),
1 .89 (s, 3H).
483 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.74 (d, J = 2.2 Hz,
1 H), 8.48 (s, 1 H), 8.29 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 2.91 (s, 3H), 2.23 - 2.12 (m, 6H), 2.12 - 2.01 (m, 6H).
484 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.72 (d, J = 2.2 Hz, compound 1 H-NMR
1 H), 8.47 (s, 1 H), 8.30 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.59 - 4.47 (m, 2H), 4.10 - 3.92 (m, 2H), 2.90 (s, 3H), 2.30 (p, J = 7.8 Hz, 2H), 2.21 - 2.1 1 (m, 6H), 2.07 (d, J = 8.0 Hz, 6H).
485 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 2H), 8.47 (s, 1 H), 8.42 (s, 1 H), 7.91 (d,
J = 5.0 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 2.91 (s, 3H), 2.73 (d, J = 0.8 Hz, 3H), 2.23 - 2.1 1 (m, 6H), 2.07 - 1.95 (m, 6H).
486 1 H NMR (400 MHz, Methanol-d4) δ 8.80 - 8.71 (m, 2H), 8.47 (s, 1 H), 8.34 (s, 1 H),
7.91 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 3.59 (s, 3H), 2.90 (s, 3H), 2.27 - 2.16 (m, 6H), 2.14 - 2.05 (m, 6H).
487 1 H NMR (400 MHz, Methanol-d4) δ 8.81 (s, 1 H), 8.77 (d, J = 2.2 Hz, 1 H), 8.65 (s,
1 H), 8.61 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.36 (s, 2H), 3.69 (s, 3H), 2.62 (s, 6H).
488 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (s, 1 H), 8.76 (d, J = 2.2 Hz, 1 H), 8.57 (s,
1 H), 8.54 (s, 1 H), 7.94 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 3.68 (s, 3H), 2.92 (s, 3H), 2.61 (s, 6H).
489 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.72 (d, J = 2.1 Hz,
1 H), 8.52 (s, 1 H), 8.46 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 2.92 (s, 3H), 2.70 (s, 1 H), 2.40 (s, 6H).
490 1 H NMR (400 MHz, Methanol-d4) δ 8.80 (s, 1 H), 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (d,
J = 2.2 Hz, 1 H), 8.45 (dd, J = 1.9, 0.8 Hz, 1 H), 8.02 (d, J = 5.0 Hz, 1 H), 7.95 (s, 1 H), 7.85 (t, J = 2.2 Hz, 1 H), 7.83 (dd, J = 2.4, 0.7 Hz, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.27 - 4.12 (m, 1 H), 1.42 (d, J = 6.4 Hz, 6H).
491 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.76 (d, J = 2.2 Hz, 1 H), 8.71 (t, J
= 2.2 Hz, 1 H), 8.70 - 8.65 (m, 2H), 8.51 (d, J = 2.2 Hz, 1 H), 8.02 (d, J = 5.0 Hz, 1 H), 7.92 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.27 - 4.12 (m, 1 H), 2.19 (s, 3H), 1.42 (d, J = 6.4 Hz, 6H).
492 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.76 (d, J = 2.1 Hz,
1 H), 8.67 (s, 1 H), 8.60 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.36 (s, 2H), 2.67 (s, 6H), 1.98 (s, 3H).
493 1 H NMR (400 MHz, Methanol-d4) δ 8.81 (s, 1 H), 8.74 (d, J = 2.1 Hz, 1 H), 8.67 (d,
J = 2.2 Hz, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.97 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 7.20 (s, 1 H), 4.28 - 4.08 (m, 1 H), 2.14 (s, 3H), 1.44 (d, J = 6.4 Hz, 6H).
494 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.77 (d, J = 2.2 Hz,
1 H), 8.62 (s, 1 H), 8.60 (s, 1 H), 7.97 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.59 (dddd, J = 48.7, 16.5, 9.3, 2.2 Hz, 1 H), 3.93 (ddd, J = 35.8, 14.6, 2.2 Hz, 1 H), 3.59 - 3.40 (m, 1 H), 2.66 (s, 6H), 1.97 (s, 3H), 1.45 (d, J = 21.7, 6H).
495 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.77 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.59 (s, 1 H), 7.97 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.50 (ddd, J = 48.9, 9.4, 2.0 Hz, 1 H), 3.92 (ddd, J = 37.1 , 14.6, 2.0 Hz, 1 H), 3.62 - 3.39 (m, 1 H), 3.30 (s, 3H), 2.66 (s, 6H), 1.97 (s, 3H), 1.27 (dd, J = 3.4, 1.7 Hz, 6H).
496 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.76 (d, J = 2.1 Hz,
1 H), 8.67 (s, 1 H), 8.60 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.36 (s, 2H), 2.67 (s, 6H), 1.98 (s, 3H).
497 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.76 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.53 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 2.65 (s, 6H), 1 .97 (s, 3H).
498 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.77 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.53 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 2.92 (s, 3H), 2.65 (s, 6H), 1.97 (s, 3H).
499 1 H NMR (400 MHz, Methanol-d4) δ 8.83 (d, J = 2.1 Hz, 1 H), 8.75 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.47 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.53 - 4.31 (m, 1 H), 4.04 - 3.77 (m, 1 H), 3.56 - 3.40 (m, 1 H), 3.34 (s, 3H), 2.43 (s, 2H), 2.34 - 2.07 (m, 6H), 1.95 - 1 .88 (m, 2H), 1.28 (d, J = 1.6 Hz, 6H).
500 1 H NMR (400 MHz, Methanol-d4) δ 8.92 (s, 1 H), 8.75 (d, J = 2.2 Hz, 1 H), 8.57 (s,
1 H), 8.53 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.1 , 9.4, 2.0 Hz, 1 H), 3.92 (ddd, J = 36.6, 14.6, 2.1 Hz, 1 H), 3.65 (s, 3H), 3.57 - 3.40 (m, 1 H), 2.40 (s, 2H), 2.32 - 2.04 (m, 6H), 1 .89 (d, J = 1 1.0 Hz, 2H), 1.28 (d, J = 1.6 Hz, 6H).
501 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 7.94 (d, J = 5.1 Hz, 1 H), 7.79 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 5.20 - 5.05 (m, 1 H), 4.42 (ddd, J =
49.1 , 9.3, 2.1 Hz, 1 H), 4.30 - 4.1 1 (m, 1 H), 3.93 (ddd, J = 36.4, 14.6, 2.1 Hz, 1 H), 3.58 - 3.41 (m, 1 H), 2.27 - 2.15 (m, 1 H), 2.12 - 2.06 (m, 1 H), 2.08 (s, 3H), 1.95 - 1 .70 (m, 5H), 1.70 - 1.55 (m, 1
H), 1.28 (d, J = 1.6 Hz, 6H).
502 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.75 (m, 1 H), 8.74 (s, 1 H), 8.70 (d, J =
2.2 Hz, 1 H), 8.61 (dd, J = 4.9, 1.4 Hz, 1 H), 8.56 (d, J = 2.2 Hz, 1 H), 8.21 (s, 1 H), compound 1H-NMR
8.11 -7.98 (m, 1H), 7.83 (d, J = 5.1 Hz, 1H), 7.76-7.65 (m, 1H), 7.16 (d, J =5.1 Hz, 1H), 4.05-3.86 (m, 1H), 3.77-3.61 (m, 1H), 2.17-2.05 (m, 2H), 2.05-1.95 (m, 2H), 1.64 - 1.32 (m, 5H), 0.89 - 0.80 (m, 2H), 0.77 - 0.68 (m, 2H).
503 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 8.25 (s, 1 H), 7.94 (d, J = 5.0 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.40 (ddd, J = 49.2, 9.5, 2.2 Hz, 1 H), 4.03 - 3.78 (m, 1 H), 3.61 - 3.36 (m, 1 H), 2.40 -2.22 (m, 6H), 2.19-1.92 (m, 6H), 1.28 (d, J = 1.7 Hz, 6H).
504 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.37 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.05 (d, J = 6.6 Hz, 1 H), 3.93 (ddd, J = 36.6, 14.6, 2.1 Hz, 1H), 3.56-3.39 (m, 1H), 2.45 (d, J =9.4 Hz, 1H), 2.38-2.28 (m, 1H), 2.28 - 2.22 (m, 1 H), 2.00 - 1.81 (m, 4H), 1.69 (d, J = 9.4 Hz, 1 H), 1.47 (q, J = 8.9, 7.8 Hz, 1 H), 1.28 (d, J = 1.6 Hz, 6H).
505 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 6.28- 6.14 (m, 2H), 5.65 (t, J = 6.0 Hz, 1H), 4.31 -4.15 (m, 1 H), 4.15 - 4.03 (m, 1H), 3.95-3.82 (m, 1H), 3.82-3.66 (m, 1H), 2.12 - 1.96 (m, 6H), 1.97 - 1.84 (m, 1 H), 1.82 - 1.73 (m, 1 H), 1.73 - 1.63 (m, 4H), 1.62 - 1.30 (m, 4H).
506 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.51 (d, J = 0.6 Hz, 1 H), 8.27 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1H), 3.97-3.77 (m, 1H), 3.75-3.58 (m, 1H), 2.35-2.14 (m, 6H), 2.10-1.95 (m, 4H), 1.95 - 1.80 (m, 6H), 1.66 - 1.26 (m, 5H), 0.88 - 0.80 (m, 2H), 0.76 - 0.67 (m, 2H).
507 1 H NMR (400 MHz, Methanol-d4) δ 8.81 (s, 1 H), 8.77 (d, J = 2.1 Hz, 1 H), 8.61 (s,
1 H), 8.60 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.2, 9.3, 2.0 Hz, 1 H), 4.10 - 3.82 (m, 1 H), 3.68 (s, 3H), 3.53 - 3.39 (m, 1 H), 2.61 (s, 6H), 1.28 (d, J = 1.6 Hz, 6H).
508 1 H NMR (400 MHz, Methanol-d4) δ 8.80 (d, J = 2.2 Hz, 1 H), 8.77 (d, J = 2.2 Hz,
1 H), 8.62 (s, 1 H), 8.60 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.55-4.30 (m, 1H), 4.03-3.83 (m, 1H), 3.47 (td, J = 15.6, 9.4 Hz, 1H), 2.66 (s, 6H), 1.98 (s, 3H), 1.28 (d, J = 1.6 Hz, 6H).
509 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.84 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.81 - 4.70 (m, 1 H), 4.42 (ddd, J =
49.0, 9.4, 2.1 Hz, 1H), 4.14-4.03 (m, 1H), 3.93 (ddd, J =36.5, 14.5, 2.1 Hz, 1H), 3.53 - 3.41 (m, 1 H), 2.45 - 2.28 (m, 1 H), 2.09 - 1.78 (m, 4H), 1.78 - 1.47 (m, 3H), 1.28 (d, J = 1.6 Hz, 6H).
510 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.68 (d, J = 2.1 Hz,
1 H), 8.56 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.67 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.53 - 4.33 (m, 1 H), 4.32 - 4.22 (m, 1 H), 4.03 - 3.82 (m, 1 H), 3.59 - 3.37 (m, 1 H), 2.82 - 2.62 (m, 2H), 2.39 - 2.23 (m, 2H), 2.24 - 2.05 (m, 4H), 1.32 (s, 3H), 1.29 (d, J = 1.6 Hz, 6H).
511 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.68 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 4.28 (p, J =7.6 Hz, 1H), 4.16 (p, J =7.4 Hz, 1 H), 4.04 - 3.80 (m, 1 H), 3.57 - 3.39 (m, 1 H), 2.77 - 2.50 (m, 3H), 2.41 - 2.30 (m, 1H), 2.16 (dd, J = 11.4, 7.8 Hz, 2H), 2.10-1.92 (m, 2H), 1.28 (d, J = 1.7 Hz, 6H).
512 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.51 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.89 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.28 - 4.16 (m, 1 H), 4.15 - 4.04 (m, 1 H), 2.92 (s, 3H), 2.13 - 1.96 (m, 2H), 1.92 - 1.79 (m, 1H), 1.87 - 1.49 (m, 5H).
513 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.97 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.31 -4.19 (m, 1H), 4.18-4.07 (m, 1H), 2.15-1.99 (m, 2H), 2.00- 1.85 (m, 1H), 1.85 - 1.75 (m, 1 H), 1.76 - 1.65 (m, 3H), 1.65 - 1.56 (m, 3H), 1.42 - 1.32 (m, 2H).
514 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.51 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.27- 4.17 (m, 1 H), 4.15 - 4.04 (m, 1H),2.91 -2.80 (m, 1 H), 2.12 - 1.96 (m, 2H), 1.97 - 1.84 (m, 1 H), 1.83 - 1.46 (m, 5H), 0.90 - 0.80 (m, 2H), 0.70 - 0.60 (m, 2H).
515 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.94 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.57 - 4.30 (m, 1 H), 4.06 - 3.83 (m, 2H), 3.62 - 3.41 (m, 1 H), 3.37 - 3.31 (m, 1 H), 2.96 (s, 3H), 2.70 (d, J = 12.4 Hz, 1H), 2.35-2.01 (m, 3H), 1.80-1.41 (m, 4H), 1.28 (d, J = 1.7 Hz, 6H).
516
517 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.63 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.93 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.55 - 4.33 (m, 2H), 3.94 (ddd, J = compound 1 H-NMR
36.6, 14.5, 2.1 Hz, 1 H), 3.62 - 3.43 (m, 1 H), 3.41 - 3.31 (m, 1 H), 2.98 (s, 3H), 2.36 - 2.21 (m, 2H), 2.21 - 2.10 (m, 1 H), 2.09 - 1 .98 (m, 1 H), 1.98 - 1.84 (m, 3H), 1 .83 - 1.69 (m, 1 H), 1.29 (d, J = 1
.6 Hz, 6H).
518 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.50 (ddd, J = 48.9, 9.4, 2.1 Hz, 1 H), 4.04 - 3.76 (m, 3H), 3.58 - 3.37 (m, 1 H), 3.31 (s, 3H), 2.31 (d, J = 12.3 Hz, 1 H), 2.12 - 1.84 (m, 3H), 1.69 - 1.32 (m, 4H), 1.31 - 1 .23 (m, 6H).
519 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.66 (s, 1 H), 8.56 (d,
J = 2.2 Hz, 1 H), 8.11 (s, 1 H), 8.05 (s, 1 H), 7.82 (d, J = 5.1 Hz, 1 H), 7.78 (d, J = 0.8 Hz, 1 H), 7.18 (d, J = 5.1 Hz, 1 H), 6.29 (tt, J = 55.0, 3.7 Hz, 1 H), 4.67 (td, J = 14.7, 3.6 Hz, 2H), 4.06 - 3.83 (m, 1 H), 3.83 - 3.60 (m, 1 H), 2.18 - 1.92 (m, 4H), 1 .66 - 1 .32 (m, 5H), 0.88 - 0.80 (m, 2H), 0.78 - 0.68 (m, 2H).
520 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.1 Hz,
1 H), 8.53 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.84 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.51 - 4.30 (m, 3H), 4.03 - 3.81 (m, 1 H), 3.55 - 3.37 (m, 1 H), 2.45 - 2.26 (m, 2H), 1 .92 (d, J = 4.7 Hz, 3H), 1 .80 (d, J = 14.2 Hz, 1 H), 1.28 (d, J = 1 .7 Hz, 6H).
521 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.55 (d, J = 0.8 Hz, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.81 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.27 - 4.00 (m, 2H), 3.22 (p, J = 6.8 Hz, 1 H), 2.96 (s, 3H), 2.22 - 2.08 (m, 2H), 2.09 - 1.98 (m, 4H), 1.88 - 1 .73 (m, 2H), 1.39 (d, J = 6.4 Hz, 6H).
522 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.54 - 4.30 (m, 3H), 3.92 (ddd, J =
36.5, 14.5, 2.1 Hz, 1 H), 3.57 - 3.41 (m, 1 H), 2.55 - 2.41 (m, 1 H), 2.34 - 2.24 (m, 1 H), 2.20 - 2.08 (m, 1 H), 1.97 - 1 .82 (m, 1 H), 1.82 - 1.63 (m, 1 H), 1 .28 (d, J = 1.7 Hz, 6H).
523 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.62 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.85 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.43 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.24 (s, 1 H), 3.96 (ddd, J = 36.5, 14.5, 2.1 Hz, 1 H), 3.58 - 3.39 (m, 1 H), 3.28 - 3.18 (m, 1 H), 2.96 (s, 3H), 2.31 - 2.10 (m, 4H), 2.00 - 1.79 (m, 4H), 1.28 (d, J = 1.6 Hz, 6H).
524 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.62 (s, 1 H), 8.03 (d, J = 5.0 Hz, 1 H), 7.88 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.1 , 9.4, 2.0 Hz, 1 H), 4.23 - 3.98 (m, 4H), 3.99 - 3.83 (m, 1 H), 3.82 - 3.70 (m, 4H), 3.58 - 3.42 (m, 3H), 2.64 - 2.54 (m, 1 H), 2.29 - 2.17 (m, 2H), 2.17 - 2.05 (m, 1 H), 1.79 - 1.38 (m, 4H), 1.28 (d, J = 1.6 Hz, 6H).
525 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.72 (d, J = 2.2 Hz,
1 H), 8.55 (s, 2H), 7.89 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.41 (dd, J = 49.7, 8.8 Hz, 1 H), 3.92 (dd, J = 36.6, 14.5 Hz, 1 H), 3.59 - 3.39 (m, 1 H), 2.48 - 2.34 (m, 2H), 2.25 - 2.14 (m, 4H), 2.09 (d, J = 12.0 Hz, 2H), 1 .89 - 1.78 (m, 3H), 1 .78 - 1 .65 (m, 2H), 1.28 (d, J = 1.6 Hz, 6H).
526 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.60 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 5.22 - 5.05 (m, 2H), 4.78 - 4.68 (m, 2H), 3.92 (s, 2H), 3.68 (s, 1 H), 2.25 - 1 .78 (m, 5H), 1.62 - 1.32 (m, 4H), 0.92 - 0.80 (m, 2H), 0.78 - 0.68 (m, 2H).
527 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1 H), 8.66 (d, J = 2.1 Hz,
1 H), 8.50 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.84 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.04 - 3.77 (m, 3H), 3.67 (s, 1 H), 2.30 (d, J = 12.0 Hz, 1 H), 2.15 - 1 .83 (m, 8H), 1 .65 - 1.33 (m, 8H), 0.91 - 0.79 (m, 2H), 0.74 (dt, J = 8.1 , 3.2 Hz, 2H).
528 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1 H), 8.46 (s, 1 H), 7.97 (d, J = 5.1 Hz, 1 H), 7.80 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.28 - 4.13 (m, 1 H), 4.04 - 3.81 (m, 1 H), 3.52 - 3.36 (m, 1 H), 2.04 - 1.85 (m, 2H), 1 .85 - 1 .65 (m, 3H), 1.62 - 1.48 (m, 1 H), 1 .29 (s, 3H), 1.28 (d, J = 1.7 Hz, 6H).
529 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.04 (d, J = 5.0 Hz, 1 H), 7.89 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.18 - 4.04 (m, 1 H), 4.01 - 3.79 (m, 1 H), 3.58 - 3.40 (m, 1 H), 2.22 - 2.02 (m, 2H), 2.00 - 1 .82 (m, 1 H), 1.78 - 1.65 (m, 2H), 1 .53 - 1 .32 (m, 3H), 1.30 - 1.25 (m, 9H).
530 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.66 (d, J = 2.1 Hz,
1 H), 8.54 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.86 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.75 - 4.43 (m, 1 H), 4.03 - 3.74 (m, 3H), 3.61 - 3.41 (m, 1 H), 2.31 (d, J = 12.7 Hz, 1 H), 2.04 (d, J = 1 1.9 Hz, 1 H), 1.94 (m, 2H), 1.67 - 1.24 (m, 10H).
531 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.85 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.59 (dddd, J = 48.6, 16.6, 9.3, 2.2 Hz, 1 H), 4.16 (p, J = 6.4 Hz, 1 H), 3.93 (ddd, J = 35.5, 14.6, 2.2 Hz, 1 H), 3.61 - 3.42 (m, 1 H), 1.46 (d, J = 21.8, 1.9 Hz, 6H), 1.40 (d, compound 1 H-NMR
J = 6.4 Hz, 6H).
532 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.04 (d, J = 5.1 Hz, 1 H), 7.94 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.53 - 4.30 (m, 1 H), 4.01 - 3.82 (m, 3H), 3.55 - 3.40 (m, 1 H), 2.39 (d, J = 12.0 Hz, 1 H), 2.13 (d, J = 13.1 Hz, 1 H), 1.93 (s, 4H), 1.61 (d, J = 13.2 Hz, 1 H), 1 .42 (s, 1 H), 1 .28 (d, J = 1.6 Hz, 8H).
533 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.88 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.2, 9.4, 2.1 Hz, 1 H), 4.10 - 3.80 (m, 2H), 3.59 - 3.45 (m, 1 H), 3.42 - 3.32 (m, 1 H), 2.45 (d, J = 1 1.9 Hz, 1 H), 2.21 (d, J = 12.6 Hz, 1 H), 2.16 - 1 .94 (m, 2H), 1.73 - 1.57 (m, 1 H), 1.58 - 1 .47 (m, 1 H), 1.48 - 1.36 (m, 2H), 1 .28 (d, J = 1.7 Hz, 6H).
534 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.78 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.53 - 4.31 (m, 2H), 3.94 (ddd, J =
36.5, 14.6, 2.1 Hz, 1 H), 3.56 - 3.40 (m, 3H), 2.57 (s, 1 H), 2.45 (ddd, J = 12.2, 7.6,
3.6 Hz, 2H), 2.33 - 2.20 (m, 2H), 1.59 (ddd, J = 12.7, 8.0, 4.7 Hz, 1 H), 1 .29 (d, J =
1 .7 Hz, 6H), 0.88 (dt, J = 4
.5, 3.0 Hz, 2H), 0.78 (dt, J = 8.0, 3.2 Hz, 2H).
535 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.1 Hz,
1 H), 8.64 (s, 1 H), 8.05 - 7.99 (m, 1 H), 7.89 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.5, 2.2 Hz, 1 H), 4.07 (s, 1 H), 3.91 (ddd, J = 36.5, 14.6, 2.2 Hz, 1 H), 3.61 - 3.43 (m, 1 H), 2.23 - 1 .71 (m, 8H), 1.45 (s, 3H), 1.29 (d, J = 1 .7 Hz, 6H).
536 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.1 Hz,
1 H), 8.58 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.70 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.54 - 4.33 (m, 2H), 3.94 (ddd, J =
36.5, 14.5, 2.1 Hz, 1 H), 3.71 (d, J = 6.2 Hz, 2H), 3.50 (ddd, J = 16.1 , 14.5, 9.4 Hz, 1 H), 2.65 - 2.41 (m, 3H), 2.34 - 2.20 (m, 2H), 1.29 (d, J = 1.7 Hz, 6H).
537 1 H NMR (400 MHz, Methanol-d4) δ 8.59 (d, J = 2.1 Hz, 1 H), 8.55 (d, J = 1.8 Hz,
2H), 8.52 (s, 1 H), 7.83 (d, J = 4.7 Hz, 1 H), 7.10 (d, J = 4.8 Hz, 1 H), 5.51 (d, J = 28.9 Hz, 1 H), 4.61 - 4.32 (m, 2H), 3.95 - 3.75 (m, 1 H), 2.21 - 2.07 (m, 6H), 1.89 - 1 .73 (m, 6H), 1.28 (d, J = 1.7 Hz, 6H).
538 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (m, 2H), 8.57 (s, 1 H), 8.00 (d, J = 5.0 Hz,
1 H), 7.77 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.55 - 4.29 (m, 2H), 3.94 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.57 - 3.44 (m, 1 H), 3.43 (d, J = 7.6 Hz, 2H), 2.62 - 2.50 (m, 1 H), 2.51 - 2.38 (m, 2H), 2.32 - 2.17 (m, 4H), 1.29 (d, J = 1 .6 Hz, 6H), 1.16 (t, J = 7.6 Hz, 3H).
539 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (s, 1 H), 8.75 (d, J = 2.1 Hz, 1 H), 8.57 (s,
1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.84 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.95 - 4.87 (m, 1 H), 4.55 - 4.30 (m, 2H), 4.05 - 3.83 (m, 1 H), 3.57 - 3.40 (m, 1 H), 3.34 (d, J = 7.4 Hz, 2H), 2.59 - 2.39 (m, 3H), 2.26 (q, J = 10.2, 9.6 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H), 1.24 (d, J = 6.3 Hz, 6H).
540 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (s, 1 H), 8.75 (d, J = 2.2 Hz, 1 H), 8.57 (s,
1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.83 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.54 - 4.30 (m, 2H), 4.12 (q, J = 7.1 Hz, 2H), 3.94 (ddd, J = 36.6, 14.6, 2.0 Hz, 1 H), 3.49 (td, J = 15.6, 9.4 Hz, 1 H), 3.35 (d, J = 7.5 Hz, 2H), 2.54 (s, 1 H), 2.47 (s, 2H), 2.26 (q, J = 9.4 Hz, 2H), 1.29 (d, J = 1 .6 Hz, 6H), 1 .25 (t, J = 7.1 Hz, 3H).
541 1 H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.70 (m, 2H), 8.57 (s, 1 H), 8.00 (d, J =
5.1 Hz, 1 H), 7.81 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.54 - 4.28 (m, 2H), 3.94 (dd, J = 36.5, 14.5 Hz, 1 H), 3.48 (td, J
= 15.4, 9.3 Hz, 1 H), 3.41 (d, J = 7.7 Hz, 2H), 2.93 (d, J = 1.7 Hz, 6H), 2.56 (s, 1 H), 2.46 (d, J = 8.7 Hz, 2H), 2.23 (q, J = 10.0, 9.6 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
542 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (m, 2H), 8.58 (s, 1 H), 7.98 (d, J = 5.0 Hz,
1 H), 7.81 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.56 - 4.31 (m, 2H), 3.94 (ddd, J = 36.6, 14.5, 2.1 Hz, 1 H), 3.61 - 3.40 (m, 3H), 2.65 (dd, J = 8.2, 3.5 Hz, 1 H), 2.48 (ddd, J = 1 1.8, 7.7, 3.8 Hz, 2H), 2.39 - 2.24 (m, 2H), 1.29 (d, J = 1 .7 Hz, 6H).
543 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.72 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.22 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.40 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 3.91 (ddd, J = 36.6, 14.5, 2.1 Hz, 1 H), 3.67 (s, 3H), 3.47 (ddd, J = 15.9, 14.6, 9.4 Hz, 1 H), 2.45 (t, J = 6.9 Hz, 2H), 2.26 (d, J = 6.3 Hz, 2H), 2.20 - 2.03 (m, 4H), 2.01 - 1 .88 (m, 6H), 1.28 (d, J = 1 .7 Hz, 6H).
544 1 H NMR (400 MHz, Methanol-d4) δ 8.76 - 8.69 (m, 2H), 8.57 (s, 1 H), 7.99 (d, J =
5.0 Hz, 1 H), 7.73 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.57 - 4.25 (m, 2H), 3.93 (dd, J = 36.8, 14.4 Hz, 1 H), 3.49 (td, J
= 15.4, 9.4 Hz, 1 H), 3.42 (d, J = 7.7 Hz, 2H), 2.57 (s, 1 H), 2.50 - 2.35 (m, 1 H), 2.27 (q, J = 9.5 Hz, 2H), 1.98 (s, 2H), 1.29 (d, J = 1 .6 Hz, 6H).
545 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (s, 1 H), 8.75 (d, J = 2.1 Hz, 1 H), 8.57 (s,
1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.81 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.53 - 4.33 (m, compound 1 H-NMR
2H), 4.03 - 3.80 (m, 1 H), 3.68 (s, 3H), 3.56 - 3.41 (m, 1 H), 3.35 (d, J = 7.5 Hz, 2H), 2.55 (s, 1 H), 2.46 (s, 2H), 2.26 (q, J = 9.4 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
546 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (q, J = 2.2 Hz, 2H), 8.58 (s, 1 H), 8.50 (s,
1 H), 7.92 (d, J = 5.2 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.1 , 9.4, 2.0 Hz, 1 H), 4.02 - 3.79 (m, 1 H), 3.56 - 3.38 (m, 3H), 2.28 (s, 6H), 2.00 (s, 3H), 1.28 (d, J = 1.7 Hz, 6H).
547 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.58 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.52 - 4.30 (m, 1 H), 4.01 - 3.81 (m, 1 H), 3.69 (s, 3H), 3.47 (td, J = 16.0, 9.4 Hz, 1 H), 3.39 (s, 2H), 2.28 (s, 6H), 1 .28 (d, J = 1.7 Hz, 6H).
548 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.65 (s, 1 H), 7.19 (d, J = 5.1 Hz, 1 H), 4.29 - 4.17 (m, 1 H), 3.92 (ddd, J =
36.4, 14.5, 2.1 Hz, 1 H), 3.51 (ddd, J = 16.0, 14.5, 9.3 Hz, 1 H), 2.66 (ddd, J = 13.5, 8.0, 5.8 Hz, 2H), 2.50 (tt, J = 10.8, 5.9 Hz, 1 H), 2.17 (ddd, J = 12.8, 9.7, 5.6 Hz, 2H), 1.29 (d, J = 1 .6 Hz, 6H)
, 1.20 (s, 6H).
549 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 2H), 8.56 (s, 1 H), 7.98 (d, J = 5.1 Hz,
1 H), 7.79 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.53 - 4.31 (m, 2H), 4.02 - 3.84 (m, 1 H), 3.49 (td, J = 15.3, 9.2 Hz, 1 H), 3.31 - 3.25 (m, 3H), 2.63 - 2.34 (m, 3H), 2.34 - 2.12 (m, 2H), 1.46 (s, 9H), 1.29 (d, J = 1 .6 Hz, 6H).
550 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 2H), 8.57 (d, J = 5.7 Hz, 2H), 7.92 (d,
J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.41 (dd, J = 49.9, 8.4 Hz, 1 H), 4.02 - 3.80 (m, 1 H), 3.47 (td, J = 15.5, 15.0, 9.3 Hz, 1 H), 2.26 (s, 6H), 1.46 (s, 9H), 1.28 (d, J = 1.6 Hz, 6H).
551 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.84 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.23 - 4.06 (m, 1 H), 3.85 (t, J = 13.9 Hz, 2H), 3.78 - 3.62 (m, 2H), 2.02 (s, 3H), 1 .40 (d, J = 6.4 Hz, 6H).
552 1 H NMR (400 MHz, Methanol-d4) δ 8.60 - 8.51 (m, 2H), 8.47 (d, J = 2.2 Hz, 1 H),
8.15 (s, 1 H), 7.79 (d, J = 4.9 Hz, 1 H), 7.07 (d, J = 4.8 Hz, 1 H), 3.94 - 3.78 (m, 3H), 2.97 (t, J = 14.0 Hz, 2H), 1.34 (d, J = 6.4 Hz, 6H).
553 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.50 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.83 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 6.16 (t, J = 57.3 Hz, 1 H), 4.15 (p,
J = 6.5 Hz, 1 H), 3.85 (s, OH), 3.60 (s, 3H), 3.57 - 3.33 (m, 2H), 2.54 - 2.29 (m, 1 H), 1 .96 - 1.73 (m, 1 H), 1.40 (d, J = 6.4 Hz, 6H), 1.33 (s, 3H).
554 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.16 (p, J = 6.5 Hz, 1 H), 3.85 (t, J = 14.0 Hz, 2H), 3.55 (t, J = 13.8 Hz, 2H), 1 .46 (s, 9H), 1.40 (d, J = 6.4 Hz, 6H).;1 H NMR (400 MHz, Methanol-d4) δ 8.62 (d, J = 29.2 Hz, 1 H), 8.55 (dd, J = 4.1 , 2.2 Hz, 1 H), 8.48 (d, J = 2.4 Hz, 1 H), 8.15 (d, J = 2.8 Hz, 1 H), 7.81 (t, J = 4.2 Hz, 1 H), 7.10 - 7.02 (m, 1 H), 3.83 (m, 2H), 3.54 (m, 1 H), 2.95 (m, 1 H), 1.34 (d, J = 6.4 Hz, 6H).
555 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.1 Hz,
1 H), 8.56 (d, J = 3.1 Hz, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.86 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 6.16 (t, J = 53.8 Hz, 1 H), 4.21 - 4.09 (m, 1 H), 3.71 - 3.43 (m, 2H), 2.21 - 2.04 (m, 2H), 1.51 (s, 3H), 1.40 (d, J = 6.4 Hz, 6H).
556 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (t, J = 2.3 Hz, 1 H), 8.65 (d, J = 2.1 Hz,
1 H), 8.55 (d, J = 1 .5 Hz, 1 H), 8.03 - 7.95 (m, 1 H), 7.88 (d, J = 8.1 Hz, 1 H), 7.23 - 7.17 (m, 1 H), 4.41 (ddd, J = 49.2, 9.4, 2.1 Hz, 1 H), 4.01 - 3.69 (m, 2H), 3.63 (s, 3H), 3.47 (td, J = 15.4, 9.4 Hz, 1 H), 3.04 - 3.00 (m, 2H), 2.30 - 2.10 (m, 2H), 1 .98 - 1 .83 (m, 2H), 1.44 (ddd, J = 20.7, 9.3, 4.1 Hz, 2H), 1.28 (d, J = 1 .6 Hz, 7H), 1.28 - 1.17 (m, 2H).
557 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.87 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.51 - 4.28 (m, 1 H), 4.01 - 3.72 (m, 2H), 3.48 (td, J = 15.3, 9.4 Hz, 1 H), 3.10 (d, J = 6.8 Hz, 2H), 2.20 (d, J = 12.5 Hz, 2H), 1.95 (s, 3H), 1.92 (d, J = 13.7 Hz, 3H), 1.54 - 1.34 (m, 2H), 1.28 (d, J = 1 .7 Hz, 7H), 1.29 - 1.18 (m, 2H).
558 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.55 - 4.25 (m, 1 H), 3.86 (d, J = 13.8 Hz, 1 H), 3.59 - 3.41 (m, OH), 2.88 (d, J = 7.0 Hz, 2H), 2.26 (d, J = 12.9 Hz, 2H), 1 .99 (d, J = 13.4 Hz, 2H), 1.51 (d, J = 13.4 Hz, 1 H), 1.36 (s, 1 H), 1.28 (d, J = 1.6 Hz, 7H).
559 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.85 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 6.24 (t, J = 53.8 Hz, 1 H), 4.51 - 4.31 (m, 1 H), 3.92 (dd, J = 35.7, 15.0 Hz, 1 H), 3.76 (t, J = 7.9 Hz, 2H), 3.60 - 3.40 (m, 1 H), 2.37 - 2.24 (m, 1 H), 2.24 - 2.08 (m, 1 H), 1 .57 (s, 3H), 1 .28 (d, J = 1.7 Hz, 7H). compound 1H-NMR
560 1 H NMR (400 MHz, DMSO-d6) δ 8.81 (d, J = 2.3 Hz, 1 H), 8.75 - 8.66 (m, 2H), 8.58
(d, J =2.3 Hz, 1H), 8.10 (s, 1H), 7.83 (d, J = 4.8 Hz, 1H), 7.09 (d, J =4.8 Hz, 1H), 4.90 (S, 1H), 4.82 (s, 1H), 4.43
(dd, J = 16.3, 8.4 Hz, 1H), 4.31 (dd, J = 16.6, 8.2 Hz, 1H), 3.75 (d, J = 14.9 Hz, 1H), 3.66 (d, J = 14.6 Hz, 1H), 3.51 (dd, J = 15.7, 9.4 Hz, 1H), 3.41 -3.33 (m, 1H), 1.25- 1.19 (m, 6H), 1.18- 1.1
1 (m, 6H).
561 1 H NMR (400 MHz, Acetonitrile-d3) δ 8.45 (d, J = 5.1 Hz, 2H), 8.30 (s, 2H), 8.04
(s, 1 H), 7.77 (t, J = 6.3 Hz, 1 H), 7.74 (d, J = 4.8 Hz, 1 H), 6.93 (d, J = 4.8 Hz, 1 H), 3.79 (h, J = 6.5 Hz, 1H), 3.61 (dq, J = 13.1, 6.6 Hz, 1H), 3.53-3.36 (m, 1H), 2.25 (s, 2H), 1.85 (t, J = 7.3 Hz, 2H), 1.31 (s, 3H), 1.29 (d, J = 3.1 Hz, 6H).
562 1 H NMR (400 MHz, DMSO-d6) δ 8.81 (s, 1 H), 8.72 - 8.47 (m, 3H), 8.08 (s, 1 H),
7.83 (d, J = 4.8 Hz, 1 H), 7.09 (d, J = 4.7 Hz, 1 H), 4.82 (s, 1 H), 4.34 (dd, J = 49.6, 8.8 Hz, 1H), 3.69 (dd, J =36.9, 14.2 Hz, 1H), 2.10 (s, 2H), 1.81 (s, 2H), 1.24 (s, 3H), 1.19-1.11 (m, 6H).
563 1 H NMR (400 MHz, Methanol-d4) δ 8.98 (s, 1 H), 8.90 (s, 1 H), 8.71 - 8.53 (m, 3H),
7.95 (d, J = 4.9 Hz, 1 H), 7.79 (s, 1 H), 7.69 (d, J = 2.2 Hz, 1 H), 7.44 (dd, J = 7.4, 2.2 Hz, 1H), 7.14 (d, J =4.9 Hz,
1 H), 4.43 (ddd, J = 48.9, 9.2, 2.1 Hz, 1 H), 3.94 (ddd, J = 35.8, 14.4, 2.1 Hz, 1 H), 3.64 - 3.43 (m, 1 H), 2.53 (d, J = 1.1 Hz, 3H), 1.29 (d, J = 1.7 Hz, 6H).
564 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (s, 1 H), 8.67 (d, J = 2.2 Hz, 1 H), 8.52 (d,
J = 2.2 Hz, 1 H), 8.43 (s, 1 H), 7.94 (d, J = 8.3 Hz, 1 H), 7.83 (d, J = 5.0 Hz, 1 H), 7.24 - 7.03 (m, 3H), 4.46 (ddd, J =
49.0, 9.3, 2.1 Hz, 1H), 4.02 (dd, J = 14.5, 2.1 Hz, 1H), 3.90 (d, J =3.5 Hz, 6H), 3.66 - 3.42 (m, 1 H), 1.30 (d, J = 1.7 Hz, 6H).
565 1 H NMR (400 MHz, Methanol-d4) δ 8.77 - 8.64 (m, 2H), 8.54 (dd, J = 2.2, 0.4 Hz,
1H), 8.17 (s, 1H), 7.78 (dd, J =5.1, 0.5 Hz, 1H), 7.46 (dd, J =7.9, 0.5 Hz, 1H), 7.25 -7.10 (m, 2H), 7.02 (dd, J =2.0, 0.5 Hz, 1H), 4.47 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 3.99 (ddd, J =36.5, 14.6, 2.2 Hz, 1H), 3.63-3.42 (m, 1H), 1.42 (s, 6H), 1.30 (d, J = 1.6 Hz, 6H).
566 1H NMR (400 MHz, Methanol-d4) δ 8.80 (s, 1H), 8.70 (dd, J = 17.2, 2.0 Hz, 2H),
8.49 (ddd, J = 27.4, 2.1 , 0.7 Hz, 2H), 8.20 - 8.06 (m, 2H), 7.83 (dd, J = 5.1 , 0.5 Hz, 1 H), 7.20 - 7.05 (m, 1 H), 6.91 (dd, J = 3.3, 0.9 Hz, 1 H), 4.48 (ddd, J = 49.0, 9.3, 2.2 Hz, 1 H), 3.99 (ddd, J = 36.3, 14.6, 2.2 Hz, 1 H), 3.66 - 3.42 (m, 1 H), 1.30 (d, J = 1.7 Hz, 6H).
567 1 H NMR (400 MHz, Methanol-d4) δ 8.76 - 8.63 (m, 2H), 8.54 (dd, J = 2.2, 0.4 Hz,
1H), 8.00 (s, 1H), 7.75 (dd, J =5.1, 0.5 Hz, 1H), 7.44-7.34 (m, 2H), 7.19-7.07 (m, 1 H), 7.07 - 6.89 (m, 2H), 5.37 (tt, J = 6.0, 4.9 Hz, 1 H), 5.06 (ddd, J = 7.1 , 6.0, 0.9 Hz, 2H), 4.73 (ddd, J = 7.2, 4.9, 0.9 Hz, 2H), 4.46 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1H), 4.11 -3.82 (m, 1H), 3.65-3.40 (m, 1H), 1.30 (d, J = 1.7 Hz, 6H).
568 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.63 (m, 2H), 8.54 (d, J = 2.2 Hz, 1 H),
8.11 (s, 1H), 7.78 (dd, J =5.0, 0.5 Hz, 1H), 7.41 (d, J = 9.1 Hz, 1H), 7.29 - 7.19 (m, 2H), 7.14 (d, J =5.0 Hz, 1H), 4.47 (ddd, J = 49.0, 9.4, 2.1 Hz, 1H), 3.99 (ddd, J = 36.6, 14.6, 2.1 Hz, 1H), 3.64-3.43 (m, 1H), 2.03 (s, OH), 1.30 (d, J = 1.6 Hz, 6H).
569 1 H NMR (400 MHz, Methanol-d4) δ 9.58 (d, J = 0.5 Hz, 1 H), 8.75 (d, J = 0.5 Hz,
1 H), 8.59 (s, 2H), 7.98 (d, J = 4.9 Hz, 1 H), 7.80 (dd, J = 9.2, 1.8 Hz, 1 H), 7.29 - 7.01 (m, 2H), 4.59 (ddd, J = 48.9, 9.3, 2.0 Hz, 1 H), 4.03 (ddd, J = 37.4, 14.5, 2.0 Hz, 1 H), 3.51 - 3.35 (m, 1 H), 1.31 (d, J = 1.6 Hz, 6H).
570 1 H NMR (400 MHz, Methanol-d4) δ 8.87 (d, J = 7.3 Hz, 2H), 8.78 (dd, J = 7.4, 0.7
Hz, 1 H), 8.62 (dd, J = 23.8, 2.2 Hz, 2H), 8.11 (dd, J = 2.3, 0.7 Hz, 1 H), 8.02 - 7.90 (m, 2H), 7.90-7.81 (m, 1H), 7.50 (dd, J = 7.4, 2.2 Hz, 1H), 7.14 (d, J =5.0 Hz, 1 H), 4.45 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.95 (ddd, J = 36.3, 14.5, 2.2 Hz, 1 H), 3.65 - 3.44 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
571 1 H NMR (400 MHz, Methanol-d4) δ 8.73 - 8.60 (m, 2H), 8.44 (d, J = 2.2 Hz, 1 H),
8.15 (s, 1H), 8.09 (s, 1H), 7.83 (d, J =8.4 Hz, 1H), 7.73 (d, J =5.1 Hz, 1H), 7.63 (d, J = 1.8 Hz, 1 H), 7.33 (dd, J = 8.5, 1.9 Hz, 1 H), 7.11 (d, J = 5.0 Hz, 1 H), 4.48 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 3.99 (ddd, J = 36.4, 14.6, 2.1 Hz, 1H), 3.63-3.44 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
572 1 H NMR (400 MHz, Methanol-d4) δ 9.35 (s, 1 H), 8.74 (s, 1 H), 8.68 (d, J = 2.2 Hz,
1H), 8.43 (d, J =2.2 Hz, 1H), 8.32 - 8.15 (m, 3H), 7.78 (d, J =5.1 Hz, 1H), 7.65 (dd, J = 8.7, 2.2 Hz, 1H), 7.13 (d,
J =5.1 Hz, 1H), 4.48 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 4.00 (ddd, J =36.5, 14.6, 2.1 Hz, 1H), 3.55 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
573 1 H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 2.8 Hz, 2H), 8.53 (d, J = 2.2 Hz,
1 H), 8.21 (s, 1 H), 7.77 (d, J = 5.1 Hz, 1 H), 7.51 - 7.37 (m, 1 H), 7.20 - 7.04 (m, 2H), 6.97 (d, J = 1.9 Hz, 1 H), 4.46 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.98 (ddd, J = 36.5, 14.6, 2.1 Hz, 1H), 3.71 -3.44 (m, 3H), 1.30 (d, J = 1.6 Hz, 6H).
574 1 H NMR (400 MHz, Methanol-d4) δ 8.80 - 8.61 (m, 2H), 8.47 (d, J = 2.2 Hz, 1 H), compound 1H-NMR
8.23 (s, 1H), 8.15 (d, J = 1.1 Hz, 1H), 7.98 (dd, J =8.6, 0.8 Hz, 1H), 7.75 (d, J = 5.1 Hz, 1H), 7.67 (dt, J = 1.9, 0.9
Hz, 1H), 7.23 (dd, J = 8.6, 1.8 Hz, 1H), 7.13 (d, J =5.1 Hz, 1H), 6.92 (d, J =4.6 Hz, OH), 4.48 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.00 (ddd, J = 36.5, 14.6, 2.1 Hz, 1H), 3.54 (ddd, J = 16.1, 14.5, 9
.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
575 1 H NMR (400 MHz, Methanol-d4) δ 8.82 - 8.67 (m, 3H), 8.61 (d, J = 2.2 Hz, 1 H),
8.30 (s, 1H), 8.10 (dd, J =8.4, 2.6 Hz, 1H), 7.94-7.78 (m, 2H), 7.17 (d, J =5.1 Hz, 1H), 4.47 (ddd, J = 49.1, 9.3, 2.1 Hz, 1H), 4.00 (ddd, J =36.4, 14.6, 2.1 Hz, 1H), 3.64-3.46 (m, 1H), 3.15 (d, J = 21.1 Hz, 6H), 1.30 (d, J = 1.6 Hz, 6H).
576 1 H NMR (400 MHz, Methanol-d4) δ 8.72 - 8.59 (m, 2H), 8.33 (d, J = 2.2 Hz, 1 H),
8.00 (s, 1 H), 7.75 - 7.54 (m, 3H), 7.48 - 7.35 (m, 1 H), 7.20 - 7.04 (m, 2H), 6.55 (dd, J = 3.1 , 0.9 Hz, 1 H), 4.48 (ddd, J = 48.9, 9.3, 2.1 Hz, 1 H), 3.99 (ddd, J = 36.5, 14.6, 2.1 Hz, 1H), 3.65-3.43 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
577 1 H NMR (400 MHz, Methanol-d4) δ 8.76 - 8.63 (m, 2H), 8.40 (d, J = 2.2 Hz, 1 H),
8.17 (d, J = 1.1 Hz, 1H), 8.01 (s, 1H), 7.90 (dd, J =2.0, 0.8 Hz, 1H), 7.82 - 7.67 (m, 2H), 7.46 (dd, J = 8.8, 2.0 Hz, 1 H), 7.11 (d, J = 5.1 Hz, 1 H), 4.48 (ddd, J = 49.0, 9.4,2.1 Hz, 1H), 4.13- 3.92 (m, 1 H), 3.65 - 3.42 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
578 1 H NMR (400 MHz, Methanol-d4) δ 8.66 (t, J = 1.1 Hz, 2H), 8.41 (d, J = 2.2 Hz,
1 H), 8.09 (s, 1 H), 7.81 - 7.61 (m, 2H), 7.48 (dd, J = 1.8, 0.9 Hz, 1 H), 7.38 (d, J = 3.1 Hz, 1H), 7.17-7.02 (m, 2H), 6.56 (dd, J = 3.2, 1.0 Hz, 1H), 4.48 (ddd, J = 49.1, 9.3, 2.1 Hz, 1H), 4.00 (ddd, J =36.5, 14.7, 2.1 Hz, 1H), 3.65 (s, 3H), 3.54 (ddd, J = 16.1, 14.7, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
579 1 H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.66 (m, 3H), 8.59 (d, J = 2.2 Hz, 1 H),
8.36 (s, 1 H), 8.25 (dd, J = 8.4, 0.8 Hz, 1 H), 8.09 (dd, J = 8.5, 2.5 Hz, 1 H), 7.85 (d, J =5.0 Hz, 1H), 7.15 (d, J =5.1
Hz, 1 H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.99 (ddd, J = 36.4, 14.5, 2.1 Hz, 1 H), 3.66 - 3.44 (m, 1 H), 3.00 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
580 1 H NMR (400 MHz, Methanol-d4) δ 9.23 (s, 1 H), 8.76 (s, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.49 (d, J = 2.2 Hz, 1 H), 8.21 (s, 1 H), 8.06 - 7.91 (m, 2H), 7.80 (d, J = 5.1 Hz, 1H), 7.66 (dd, J =8.8, 2.0 Hz,
1H), 7.14 (d, J =5.1 Hz, 1H), 4.48 (ddd, J = 49.1, 9.4, 2.1 Hz, 1H), 3.99 (ddd, J = 36.6, 14.6, 2.1 Hz, 1H), 3.69-3.43 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
581 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.0 Hz, 2H), 8.59 (d, J = 2.2 Hz,
1 H), 8.32 (s, 1 H), 7.81 (d, J = 5.1 Hz, 1 H), 7.63 (d, J = 7.9 Hz, 1 H), 7.47 - 7.33 (m, 2H), 7.17 (d, J =5.1 Hz, 1H), 4.46 (ddd, J = 49.1, 9.3, 2.0 Hz, 1H), 3.99 (ddd, J = 36.6, 14.5, 2.1 Hz, 1H), 3.60-3.43 (m, 1H), 2.53 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
582 1H NMR (400 MHz, Methanol-d4) δ 10.15 (s, 1H), 8.78 (s, 1H), 8.75-8.66 (m, 2H),
8.58 (s, 1H), 7.90 (d, J =5.0 Hz, 1H), 7.19 (d, J =5.0 Hz, 1H), 7.07 (s, 1H), 4.48 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 4.14-3.86 (m, 1H), 3.66-3.43 (m, 1H), 2.53 (s, 3H), 1.31 (d, J = 1.6 Hz, 6H).
583 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 1 H), 8.70 (d, J = 2.2 Hz, 1 H), 8.58 (d,
J =2.1 Hz, 1H), 8.44 (s, 1H), 7.94-7.81 (m, 2H), 7.56-7.42 (m, 2H), 7.16 (d, J = 5.0 Hz, 1H), 4.45 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 4.14-3.84 (m, 1H), 3.52 (td, J = 15.3, 9.2 Hz, 1 H), 2.61 (s, 3H), 2.03 (s, 1 H), 1.29 (d, J = 1.6 Hz, 6H).
584 1H NMR (400 MHz, DMS0-d6) δ 11.88 (s, 1H), 10.33 (s, 1H), 9.16 (t, J = 5.6 Hz,
1H), 9.08-8.77 (m, 4H), 7.92 (d, J =4.8 Hz, 1H), 7.12 (d, J =4.9 Hz, 1H), 4.40 (ddd, J =49.3, 9.4, 2.0 Hz, 1H), 4.04-3.31 (m, 25H), 1.17 (dd, J =6.1, 1.6 Hz, 6H).
585 1H NMR (400 MHz, Methanol-d4) δ 10.19 (s, 1H), 8.82 (d, J = 13.6 Hz, 2H), 8.73
(s, 2H), 7.95 (d, J =4.9 Hz, 1H), 7.28-7.12 (m, 2H), 4.47 (dd, J =48.5, 8.8 Hz, 1H), 3.99 (dd, J =35.6, 15.0 Hz, 1H), 3.68-3.43 (m, 1H), 2.56 (s, 3H), 1.31 (d, J = 1.6 Hz, 6H).
586 1 H NMR (400 MHz, Methanol-d4) δ 9.90 (s, 1 H), 8.73 - 8.52 (m, 3H), 8.49 - 8.34
(m, 1H), 7.87-7.72 (m, 2H), 7.19-7.01 (m, 2H), 4.47 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 3.93 (ddd, J = 36.6, 14.6, 2.1
Hz, 1H), 3.54 (ddd, J = 16.0, 14.5, 9.4 Hz, 1H), 1.32 (d, J = 1.7 Hz, 6H).
587 1H NMR (400 MHz, Methanol-d4) δ 10.25 (s, 1H), 8.81 (s, 1H), 8.72 (d, J = 4.9 Hz,
1H), 8.69-8.56 (m, 1H), 7.91 (d, J =5.0 Hz, 1H), 7.15 (dt, J =4.8, 2.4 Hz, 1H), 4.48 (ddd, J =49.1, 9.3, 2.1 Hz,
1H), 3.99 (ddd, J = 36.2, 14.6, 2.1 Hz, 1H), 3.69-3.47 (m, 1H), 3.26 - 3.12 (m, OH), 1.40- 1.20 (m, 6H).
588 1H NMR (400 MHz, Methanol-d4) δ 10.15 (s, 1H), 9.04 (s, 1H), 8.88 (s, 1H), 8.74
(s, 2H), 8.01 (d, J = 5.0 Hz, 1 H), 7.81 (dd, J = 8.9, 4.7 Hz, 1 H), 7.62 (d, J = 8.8 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.49 (dd, J = 49.2, 8.0 Hz, 1 H), 4.01 (dd, J = 35.1 , 13.7 Hz, 1 H), 3.67 - 3.46 (m, 1 H), 1.31 (d, J = 1.6 Hz, 6H).
589 1 H NMR (400 MHz, Methanol-d4) δ 8.77 - 8.64 (m, 2H), 8.49 (d, J = 2.2 Hz, 1 H),
8.19 (s, 1H), 7.76 (d, J =5.1 Hz, 1H), 7.59 (dd, J =8.4, 7.3 Hz, 2H), 7.52 - 7.34 (m, compound 1H-NMR
3H), 7.14 (d, J =5.0 Hz, 1H), 4.47 (ddd, J = 49.1, 9.4, 2.1 Hz, 1H), 4.19-3.91 (m, 1 H), 3.75 - 3.42 (m, 2H), 1.30 (d, J = 1.6 Hz, 6H).
590 1 H NMR (400 MHz, Methanol-d4) δ 8.77 - 8.66 (m, 3H), 8.57 (d, J = 2.1 Hz, 1 H),
7.91 (s, 1H), 7.86 (d, J =5.1 Hz, 1H), 7.15 (d, J =5.1 Hz, 1H), 4.47 (ddd, J =49.1, 9.3, 2.1 Hz, 1H), 4.10 (s, 3H), 4.07-3.90 (m, 1H), 3.63-3.44 (m, 1H), 1.30 (d, J = 1.7 Hz, 6H).
591 1 H NMR (400 MHz, Methanol-d4) δ 8.83 (s, 1 H), 8.76 - 8.65 (m, 2H), 8.58 (d, J =
2.2 Hz, 1 H), 8.26 (d, J = 5.7 Hz, 1 H), 7.91 (d, J = 5.0 Hz, 1 H), 7.38 (dt, J = 5.8, 1.5 Hz, 1 H), 7.26 - 7.14 (m, 2H), 6.93 (d, J = 4.6 Hz, OH), 4.45 (ddd, J = 48.9, 9.3, 2.2 Hz, 1H), 3.97 (ddd, J =36.2, 14.5, 2.1 Hz, 1H), 3.64-3.41 (m, 1H), 1.30 (d, J = 1.7 Hz, 6H).
592 1 H NMR (400 MHz, Methanol-d4) δ 9.03 (d, J = 1.9 Hz, 1 H), 8.91 - 8.75 (m, 2H),
8.70 (d, J = 2.2 Hz, 1 H), 8.60 (d, J = 2.1 Hz, 1 H), 8.50 (t, J = 2.2 Hz, 1 H), 8.33 (s, 1H), 7.85 (d, J =5.1 Hz, 1H), 7.16 (d, J =5.0 Hz, 1H), 4.61 - 4.36 (m, 1H), 4.10- 3.90 (m, 1 H), 3.65 - 3.44 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
593 1H NMR (400 MHz, Methanol-d4) δ 8.98 (d, J = 20.7 Hz, 2H), 8.60 (dd, J = 13.8,
2.2 Hz, 2H), 8.57 - 8.47 (m, 2H), 7.96 (d, J = 4.9 Hz, 1 H), 7.76 - 7.62 (m, 2H), 7.13 (d, J = 4.9 Hz, 1 H), 4.41 (ddd, J = 48.9, 9.3, 2.2 Hz, 1 H), 3.91 (ddd, J = 36.0, 14.5, 2.2 Hz, 1 H), 3.64 - 3.44 (m, 1 H), 1.28 (d, J = 1.7 Hz, 6H).
594 1 H NMR (400 MHz, Methanol-d4) δ 9.11 (d, J = 1.8 Hz, 1 H), 8.89 (d, J = 2.6 Hz,
1 H), 8.78 (s, 1 H), 8.70 (d, J = 2.2 Hz, 1 H), 8.63 - 8.51 (m, 2H), 8.28 (s, 1 H), 7.85 (d, J =5.1 Hz, 1H), 7.16 (d, J = 5.1 Hz, 1H), 4.47 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 4.02 (s, 3H), 3.54 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
595 1 H NMR (400 MHz, Methanol-d4) δ 8.86 (s, 2H), 8.77 (s, 1 H), 8.61 (d, J = 2.2 Hz,
1H), 8.09 (s, 1H), 7.87 (d, J = 5.1 Hz, 1H), 7.16 (d, J =5.1 Hz, 1H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 3.99 (ddd, J =36.4, 14.6, 2.1 Hz, 1H), 3.54 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 2.79 (s, 3H), 1.30 (d, J = 1.7 Hz, 6H).
596 1H NMR (400 MHz, Methanol-d4) δ 10.25 (s, 1H), 9.05 (s, 2H), 8.90 (s, 1H), 8.67
(dd, J = 19.8, 2.2 Hz, 2H), 7.95 (d, J =5.0 Hz, 1H), 7.15 (d, J = 5.0 Hz, 1H), 4.62 - 4.39 (m, 1H), 3.98 (dd, J =34.8, 13.9 Hz, 1H), 3.70-3.43 (m, 1H), 3.13 (d, J = 1.7 Hz, 1H), 1.31 (d, J = 1.6 Hz, 6H).
597 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.66 (m, 2H), 8.55 (d, J = 2.2 Hz, 1 H),
8.35 (dd, J = 2.7, 0.7 Hz, 1 H), 8.07 - 7.95 (m, 2H), 7.88 - 7.76 (m, 1 H), 7.62 (s, OH), 7.44 (s, OH), 7.26 - 7.10 (m, 2H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.99 (ddd, J =36.4, 14.5, 2.1 Hz, 1H), 3.63-3.44 (m, 1H), 1.30 (d, J = 1.7 Hz, 6H).
598 1H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 16.0 Hz, 2H), 8.61 (d, J =2.2 Hz,
1H), 8.48 (d, J =2.2 Hz, 1H), 8.13 (d, J =6.2 Hz, 1H), 7.86 (d, J =5.0 Hz, 1H), 7.16 - 7.03 (m, 2H), 6.92 (d, J = 2.0 Hz, 1 H), 4.44 (ddd, J = 49.0, 9.3, 2.2 Hz, 1 H), 4.10-3.85 (m, 4H), 3.52 (ddd, J = 16.2, 14.6, 9.3 Hz, 1H), 1.29 (d, J = 1.7 Hz, 6H).
599 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.64 (m, 2H), 8.54 (d, J = 2.2 Hz, 1 H),
8.38-8.31 (m, 1H), 8.16-8.01 (m, 2H), 7.83 (d, J =5.1 Hz, 1H), 7.30 (dd, J =8.7, 3.0 Hz, 1H), 7.14 (d, J =5.1 Hz,
1 H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.09 - 3.92 (m, 1 H), 3.65 (s, 1 H), 3.57 - 3.47 (m, 1 H), 1.30 (d, J = 1.7 Hz, 6H).
600 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (s, 1 H), 8.71 (d, J = 2.2 Hz, 1 H), 8.66 - 8.50 (m, 3H), 8.25 (s, 1H), 7.95-7.80 (m, 2H), 7.17 (d, J =5.1 Hz, 1H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.99 (ddd, J = 36.4, 14.6, 2.1 Hz, 1 H), 3.54 (ddd, J = 16.2, 14.5, 9.3 Hz, 1H), 1.30 (d, J = 1.7 Hz, 6H).
601 1H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 10.9 Hz, 2H), 8.69 (d, J =2.1 Hz,
1H), 8.59 (d, J =2.1 Hz, 1H), 8.39 (s, 1H), 8.28 (d, J =8.3 Hz, 1H), 8.10 (dd, J = 8.3, 2.4 Hz, 1H), 7.86 (d, J = 5.0
Hz, 1H), 7.15 (d, J = 5.0 Hz, 1H), 4.47 (dd, J =49.0, 9.2 Hz, 1H), 3.99 (dd, J = 36.4, 14.6 Hz, 1 H), 3.53 (ddd, J = 21.8, 15.6, 7.9 Hz, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
602 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.63 (m, 2H), 8.54 (d, J = 2.1 Hz, 1 H),
8.26 (dd, J =2.8, 0.7 Hz, 1H), 7.91 (s, 1H), 7.87-7.75 (m, 2H), 7.15 (d, J =5.1 Hz, 1 H), 7.02 (dd, J = 8.8, 0.7 Hz, 1 H), 5.49 (s, OH), 4.47 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1H), 3.99 (s, 3H), 3.52 (ddd, J = 16.0, 14.6, 9.4 Hz, 1H), 1.35- 1.23 (m, 6H).
603 1H NMR (400 MHz, DMS0-d6) δ 10.70 (s, 1H), 9.05 (d, J =6.1 Hz, 1H), 8.97 - 8.81 (m, 2H), 8.80 - 8.65 (m, 3H), 8.19 - 8.01 (m, 2H), 7.86 (d, J = 4.8 Hz, 1 H), 7.11 (d, J = 4.8 Hz, 1 H), 5.74 (s, 1 H), 4.86 (s, 1 H), 4.37 (ddd, J = 49.3, 9.4, 2.1 Hz, 1H), 4.01 (s, OH), 3.88-3.70 (m, 1H), 3.43 (dd, J = 15.3, 10.4 Hz, 1H), 2.05 (s, 1H), 1.16 (dd, J =5.3, 1.6 Hz, 6H).
604 1 H NMR (400 MHz, Methanol-d4) δ 8.80 - 8.66 (m, 2H), 8.58 (d, J = 2.1 Hz, 1 H),
8.43 (s, 1H), 8.14 (d, J =8.3 Hz, 1H), 7.84 (d, J =5.0 Hz, 1H), 7.29-7.21 (m, 2H), 7.16 (d, J = 5.1 Hz, 1H), 4.47 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 4.02 (s, 4H), 3.53 (ddd, J = 16.1, 14.5, 9.4 Hz, 1H), 1.30 (d, J = 1.7 Hz, 6H).
605 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.71 (d, J = 2.2 Hz, 1 H), 8.56 (d,
J = 2.2 Hz, 1 H), 8.37 (dd, J = 14.5, 2.3 Hz, 2H), 8.25 (s, 1 H), 7.86 (d, J = 5.1 Hz, compound 1H-NMR
1H), 7.67 (t, J =2.3 Hz, 1H), 7.17 (d, J =5.1 Hz, 1H), 4.47 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 4.10-3.84 (m, 4H), 3.53 (ddd, J = 16.1, 14.5, 9.4 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
606 1 H NMR (400 MHz, Methanol-d4) δ 8.75 - 8.67 (m, 2H), 8.50 (d, J = 2.2 Hz, 1 H),
8.21 (s, 1H), 7.77 (d, J =5.1 Hz, 1H), 7.58-7.44 (m, 1H), 7.16 (d, J = 5.1 Hz, 1H), 7.08-6.92 (m, 3H), 4.46 (ddd, J
= 49.0, 9.4, 2.1 Hz, 1H), 4.12-3.92 (m, 1H), 3.87 (s, 3H), 3.61 - 3.38 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
607 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.67 (m, 2H), 8.48 (d, J = 2.2 Hz, 1 H),
8.21 (s, 1 H), 7.80 (d, J = 5.1 Hz, 1 H), 7.69 (t, J = 8.2 Hz, 1 H), 7.60 - 7.30 (m, 3H), 7.16 (d, J = 5.1 Hz, 1H), 4.47 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 3.98 (ddd, J = 36.4, 14.6, 2.1 Hz, 1H), 3.65 (s, 4H), 3.54 (ddd, J = 16.1, 14.6, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
608 1 H NMR (400 MHz, Methanol-d4) δ 8.81 - 8.65 (m, 2H), 8.59 - 8.42 (m, 1 H), 8.23
(s, 1 H), 7.79 (d, J = 5.1 Hz, 1 H), 7.61 (t, J = 8.2 Hz, 1 H), 7.40 - 7.31 (m, 2H), 7.26 - 7.06 (m, 2H), 4.47 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 4.10 - 3.89 (m, 1H), 3.53 (ddd, J = 16.2, 14.6, 9.4 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
609 1 H NMR (400 MHz, Methanol-d4) δ 8.76 - 8.62 (m, 2H), 8.53 (d, J = 2.1 Hz, 1 H),
7.98 (s, 1 H), 7.73 (d, J = 5.1 Hz, 1 H), 7.46 - 7.29 (m, 2H), 7.24 - 7.03 (m, 3H), 4.46 (ddd, J =49.0, 9.4, 2.1 Hz, 1H),
4.15-3.93 (m, 1H), 3.88 (s, 3H), 3.64-3.42 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
610 1 H NMR (400 MHz, Methanol-d4) δ 8.94 (d, J = 2.5 Hz, 1 H), 8.88 (d, J = 1.8 Hz,
1 H), 8.80 (s, 1 H), 8.70 (d, J = 2.2 Hz, 1 H), 8.58 (d, J = 2.2 Hz, 1 H), 8.42 (dd, J = 2.5, 1.8 Hz, 1H), 8.28 (s, 1H), 7.88 (d, J =5.0 Hz, 1H), 7.16 (d, J =5.1 Hz, 1H), 4.47 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 3.98 (ddd, J =36.5, 14.5, 2.1 Hz, 1H), 3.66 - 3.43 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
611 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (s, 1 H), 8.70 (d, J = 2.2 Hz, 1 H), 8.58 (d,
J = 2.2 Hz, 1 H), 8.44 (d, J = 2.5 Hz, 1 H), 7.84 (dd, J = 26.0, 7.0 Hz, 2H), 7.32 - 7.10 (m, 3H), 4.52 (dd, J = 9.0, 1.9 Hz, 1 H), 4.46 - 4.35 (m, 1 H), 3.99 (s, 4H), 3.53 (td, J = 15.5, 9.4 Hz, 1H), 1.41 - 1.17 (m, 6H).
612 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.72 (d, J = 2.2 Hz,
1 H), 8.64 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.64 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.95 (d, J = 6.6 Hz, 2H), 4.77 (d, J = 6.6 Hz, 2H), 4.38 (s, 2H), 1.88 (s, 3H).
613 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.75 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.46 (p, J = 7.5 Hz, 1 H), 4.37 (s, 2H), 3.68 (s, 3H), 3.35 (d, J = 7.4 Hz, 2H), 2.62 - 2.41 (m, 3H), 2.35 - 2.20 (m, 2H).
614 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 2H), 8.57 (s, 1 H), 7.99 (d, J = 5.1 Hz,
1H), 7.79 (s, 1H), 7.21 (d, J = 5.1 Hz, 1H), 5.13-5.01 (m, 1H), 4.79-4.71 (m, 1H), 4.71 - 4.60 (m, 1 H), 4.53 - 4.31 (m, 2H), 4.06 - 3.84 (m, 1 H), 3.64 - 3.40 (m, 3H), 3.09 - 2.99 (m, 1 H), 2.74 - 2.55 (m, 2H), 2.55 - 2.39 (m, 2H), 2.38 - 2.20 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
615 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (s, 1 H), 8.55 (s,
1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.34 - 4.23 (m, 1 H), 4.06 - 3.85 (m, 1 H), 3.68 (d, J = 7.9 Hz, 2H), 3.62 (s, 3H), 3.55-3.40 (m, 1H), 2.71 -2.57 (m, 1H), 2.43 - 2.10 (m, 4H), 1.28 (d, J = 1.7 Hz, 6H).
616 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.28 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 5.05 - 4.95 (m, OH), 4.77 - 4.66 (m, 1 H), 4.58 (dt, J = 9.2, 6.0 Hz, 1 H), 3.70 (dd, J = 14.1, 6.7 Hz, 1H), 3.59 (dd, J = 14.1, 4.0 Hz, 1H), 2.81 -2.67 (m, 1H), 2.57-2.41 (m, 1H), 2.25 (q, J =8.6 Hz, 6H), 1.90 (dd, J = 10.0, 5.8 Hz, 5H).
617
618 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.85 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 4.02 - 3.80 (m, 2H), 3.60 (s, 3H), 3.55 - 3.41 (m, 1H), 2.30 (d, J = 12.9 Hz, 2H), 1.96 (d, J = 13.0 Hz, 2H), 1.71 - 1.49 (m, 4H), 1.34 (s, 3H), 1.28 (d, J = 1.6 Hz, 6H).
619 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J =49.1, 9.4, 2.2 Hz, 1H), 4.03 (s, 1H), 3.94 (ddd, J =36.4, 14.6, 2.1 Hz, 1 H), 3.60 (s, 3H), 3.57 - 3.44 (m, 1 H), 2.25 - 1.96 (m, 4H), 1.82 - 1.65 (m, 4H), 1.37 (s, 3H), 1.29 (d, J = 1.6 Hz, 6H).
620 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.1 Hz,
1 H), 8.56 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.75 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.43 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.25 (p, J = 8.0 Hz, 1 H), 3.94 (ddd, J = 36.3, 14.5, 2.1 Hz, 1H), 3.67 (s, 3H), 3.60-3.43 (m, 1H), 3.39 (d, J = 7.0 Hz, 2H), 2.93 compound 1 H-NMR
(s, 3H), 2.80 - 2.68 (m, 2H), 2.58 - 2.41 (m, 1 H), 2.05 - 1.79 (m, 2H), 1 .29 (d, J = 1.6 Hz, 7H).
621 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.31 (s, 1 H), 7.93 (d, J = 5.0 Hz, 1 H), 7.91 (d, J = 0.9 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 7.17 (d, J = 0.9 Hz, 1 H), 4.69 (s, 2H), 2.30 - 2.18 (m, 6H), 1 .98 - 1.83 (m, 6H).
622 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.62 (s, 1 H), 8.31 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.69 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.65 (s, 2H), 2.34 - 2.16 (m, 6H), 2.09 - 1 .82 (m, 6H), 1.50 (s, 6H).
623 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.1 Hz,
1 H), 8.52 (s, 1 H), 8.29 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.15 (d, J = 2.6 Hz, 2H), 2.69 (t, J = 2.6 Hz, 1 H), 2.36 - 2.16 (m, 6H), 1 .98 - 1.82 (m, 6H).
624 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.28 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.66 - 7.57 (m, 1 H), 7.40 (dd, J = 6.6, 2.1 Hz, 1 H), 7.21 (d,
J = 5.1 Hz, 1 H), 6.40 (t, J = 6.7 Hz, 1 H), 4.39 (s, 2H), 2.43 - 2.04 (m, 6H), 2.04 - 1 .73 (m, 6H).
625 1 H NMR (400 MHz, Methanol-d4) δ 8.81 - 8.73 (m, 2H), 8.70 (d, J = 2.2 Hz, 1 H),
8.60 (d, J = 2.2 Hz, 1 H), 8.39 (s, 1 H), 8.26 (s, 1 H), 8.07 (dd, J = 8.6, 2.5 Hz, 1 H), 8.05 - 7.99 (m, 1 H), 7.85 (d, J = 5.0 Hz, 1 H), 7.82 (s, 1 H), 7.16 (d, J = 5.1 Hz, 1 H), 4.58 - 4.35 (m, 1 H), 4.18 - 3.87 (m, 1 H), 3.66 - 3.48 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
626 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.1 Hz,
1 H), 8.63 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.61 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 5.23 - 4.99 (m, 3H), 4.80 - 4.66 (m, 4H), 4.42 (t, J = 12.0 Hz, 2H), 4.13 (s, 2H).
627 1 H NMR (400 MHz, Methanol-d4) δ 9.06 (s, 1 H), 8.75 (s, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.59 (d, J = 2.2 Hz, 1 H), 8.45 (s, 1 H), 8.26 (d, J = 8.5 Hz, 2H), 7.84 (d, J = 5.0 Hz, 1 H), 7.70 (d, J = 8.5 Hz, 2H), 7.15 (d, J = 5.1 Hz, 1 H), 4.61 - 4.35 (m, 1 H), 4.08 - 3.85 (m, 1 H), 3.61 - 3.47 (m, 1 H), 1 .30 (d, J = 1 .6 Hz, 6H).
628 1 H NMR (400 MHz, Methanol-d4) δ 8.70 (s, 1 H), 8.68 (d, J = 2.2 Hz, 1 H), 8.57 (d,
J = 2.2 Hz, 1 H), 8.42 (d, J = 1.0 Hz, 1 H), 8.32 (d, J = 1.0 Hz, 1 H), 8.31 (s, 1 H), 7.98 (d, J = 8.5 Hz, 2H), 7.79 (d, J = 5.1 Hz, 1 H), 7.54 (d, J = 8.5 Hz, 2H), 7.14 (d, J = 5.1 Hz, 1 H), 4.58 - 4.31 (m, 1 H), 4.08 - 3.85 (m, 1 H), 3.62 - 3.44 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
629 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (s, 1 H), 8.71 (d, J = 2.2 Hz, 1 H), 8.57 (d,
J = 2.1 Hz, 1 H), 8.24 (s, 1 H), 8.21 (s, 1 H), 7.88 (d, J = 8.6 Hz, 2H), 7.80 (d, J = 5.0 Hz, 1 H), 7.61 (d, J = 8.6 Hz, 2H), 7.16 (d, J = 5.1 Hz, 1 H), 4.47 (ddd, J = 49.0, 9.3, 2.0 Hz, 1 H), 4.08 - 3.90 (m, 1 H), 3.62 - 3.43 (m, 1 H), 2.48 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
630 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.1 1 (s, 1 H), 8.02 (d, J = 5.0 Hz, 1 H), 7.88 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 6.90 (d, J = 1 .0 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 4.06 - 3.76 (m, 2H), 3.67 - 3.37 (m, 1 H), 2.88 (t, J = 11.8 Hz, 1 H), 2.46 - 2.1 1 (m, 4H), 1 .89 - 1.51 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
631 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 8.00 (s, 1 H), 7.88 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.51 - 4.30 (m, 1 H), 4.08 - 3.80 (m, 2H), 3.55 - 3.41 (m, 1 H), 2.99 - 2.84 (m, 1 H), 2.29 (d, J = 12.7 Hz, 2H), 2.16 (s, 3H), 2.05 - 1 .81 (m, 4H), 1.72 - 1 .55 (m, 2H), 1.29 (d, J = 1.7 Hz, 7H).
632 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.7 Hz, 1 H), 8.75 (s, 1 H), 8.69 (d,
J = 2.2 Hz, 1 H), 8.55 (d, J = 2.2 Hz, 1 H), 8.26 (s, 1 H), 8.22 (s, 1 H), 8.02 (dd, J = 8.6, 2.6 Hz, 1 H), 7.93 (d, J = 8.6 Hz, 1 H), 7.84 (d, J = 5.0 Hz, 1 H), 7.14 (d, J = 5.0 Hz, 1 H), 4.58 - 4.35 (m, 1 H), 4.10 - 3.86 (m, 1 H), 3.67 - 3.43 (m, 1 H), 2.63 (s, 3H), 1 .30 (d, J = 1.6 Hz, 6H).
633 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.75 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.35 (s, 1 H), 8.18 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 7.10 (s, 1 H), 4.41 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.30 (s, 2H), 3.92 (ddd, J = 36.6, 14.6, 2.1 Hz, 1 H), 3.59 - 3.41 (m, 1 H), 2.65 - 2.50 (m, 2H), 2.46 - 2.36 (m, 4H), 2.33 - 2.22 (m, 2H), 1.28 (d, J = 1.7 Hz, 6H).
634 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.32 (s, 1 H), 8.03 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.31 (s, 2H), 3.92 (ddd, J = 36.5, 14.5, 2.1 Hz, 1 H), 3.61 - 3.38 (m, 1 H), 2.50 (dd, J = 15.8, 9.0 Hz, 2H), 2.45 - 2.30 (m, 6H), 2.28 (s, 3H), 1.28 (d, J = 1 .7 Hz, 6H).
635 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (s, 1 H), 8.69 (d, J = 2.1 Hz, 1 H), 8.60 (d,
J = 2.2 Hz, 1 H), 8.44 (d, J = 2.0 Hz, 1 H), 8.43 (s, 1 H), 8.34 (s, 1 H), 7.85 (d, J = 5.1 Hz, 1 H), 7.84 (s, 1 H), 7.68 (d, J = 2.0 Hz, 1 H), 7.15 (d, J = 5.0 Hz, 1 H), 4.57 - 4.39 compound 1 H-NMR
(m, 1 H), 4.33 (q, J = 7.0 Hz, 2H), 4.10 - 3.91 (m, 1 H), 3.60 - 3.46 (m, 1 H), 1.58 (t, J = 6.9 Hz, 3H), 1.30 (d, J = 1.6 Hz, 6H).
636
637 1 H NMR (400 MHz, Methanol-d4) δ 8.89 (s, 1 H), 8.74 (d, J = 2.1 Hz, 1 H), 8.67 (d,
J = 2.1 Hz, 1 H), 8.58 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.91 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.05 - 3.81 (m, 2H), 3.60 - 3.39 (m, 1 H), 3.23 - 3.05 (m, 1 H), 2.32 (d, J = 11 .4 Hz, 4H), 1.91 (q, J = 1 1.4 Hz, 2H), 1 .74 - 1 .57 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
638 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.1 1 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.64 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 6.92 (s, 1 H), 4.57 - 4.30 (m, 2H), 4.08 - 3.83 (m, 1 H), 3.58 - 3.42 (m, 1 H), 3.08 - 2.95 (m, 2H), 2.88 - 2.73 (m, 1 H), 2.59 - 2.43 (m, 2H), 2.42 - 2.30 (m, 2H), 1.29 (d, J = 1 .7 Hz, 6H).
639 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.21 (s, 1 H), 8.05 (d, J = 5.1 Hz, 1 H), 7.95 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 7.16 (d, J = 0.8 Hz, 1 H), 4.72 (dd, J = 9.6, 3.6 Hz, 1 H), 4.43 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 4.31 - 4.21 (m, 1 H), 4.20 - 4.08 (m, 1 H), 3.93 (ddd, J = 36.3, 14.5, 2.1 Hz, 1 H), 3.62 - 3.42 (m, 2H), 2.44 - 2.35 (m, 1 H), 2.27 - 2.05 (m, 2H), 1 .99 - 1.81 (m, 1 H), 1.29 (d, J = 1.6 Hz, 6H).
640 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.09 (s, 1 H), 7.97 (d, J = 5.1 Hz, 1 H), 7.73 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 6.88 (d, J = 1 .1 Hz, 1 H), 4.56 - 4.33 (m, 1 H), 4.33 - 4.19 (m, 1 H), 4.08 - 3.79 (m, 1 H), 3.65 - 3.41 (m, 1 H), 2.91 (d, J = 7.3 Hz, 2H), 2.89 - 2.77 (m, 2H), 2.68 - 2.48 (m, 1 H), 1.95 - 1.76 (m, 2H), 1.29 (d, J = 1 .6 Hz, 6H).
641 1 H NMR (400 MHz, Methanol-d4) δ 9.02 (s, 2H), 8.79 (s, 1 H), 8.72 (d, J = 2.1 Hz,
1 H), 8.63 (d, J = 2.1 Hz, 1 H), 8.47 (s, 1 H), 8.22 (s, 1 H), 8.01 (s, 1 H), 7.90 (d, J = 5.1 Hz, 1 H), 7.16 (d, J = 5.1 Hz, 1 H), 4.63 - 4.35 (m, 1 H), 4.21 - 3.87 (m, 1 H), 3.73 - 3.44 (m, 1 H), 1.30 (d, J = 1 .6 Hz, 6H).
642 1 H NMR (400 MHz, Methanol-d4) δ 9.38 (s, 1 H), 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d,
J = 2.2 Hz, 1 H), 8.58 (s, 1 H), 8.04 (d, J = 5.1 Hz, 1 H), 7.91 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.43 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 4.09 - 3.75 (m, 2H), 3.63 - 3.34 (m, 2H), 2.34 (t, J = 5.0 Hz, 5H), 2.05 (s, 1 H), 1.95 (q, J = 11 .6 Hz, 2H), 1.81 - 1.61 (m, 2H), 1.29 (d, J = 1 .6 Hz, 6H).
643 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.1 Hz,
1 H), 8.54 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.83 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.34 - 4.08 (m, 2H), 4.04 - 3.83 (m, 1 H), 3.82 - 3.62 (m, 1 H), 1.40 (d, J = 6.4 Hz, 6H), 0.95 - 0.64 (m, 4H).
644
645 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 6.76 (d, J = 1.2 Hz, 1 H), 4.41 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.24 - 4.15 (m, 1 H), 4.05 - 3.82 (m, 1 H), 3.59 - 3.42 (m, 1 H), 3.02 - 2.90 (m, 1 H), 2.42 (s, 3H), 2.17 - 1 .90 (m, 6H), 1.90 - 1.74 (m, 2H), 1.28 (d, J = 1.7 Hz, 6H).
646 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.88 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 6.73 (d, J = 1.0 Hz, 1 H), 4.56 - 4.29 (m, 1 H), 4.04 - 3.82 (m, 2H), 3.60 - 3.42 (m, 1 H), 2.90 - 2.73 (m, 1 H), 2.41 (s, 3H), 2.32 - 2.13 (m, 4H), 1.83 - 1.52 (m, 4H), 1.29 (d, J = 1.7 Hz, 6H).
647 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (s, 1 H), 8.69 (d, J = 2.2 Hz, 1 H), 8.49 (d,
J = 2.2 Hz, 1 H), 8.36 (s, 1 H), 7.97 (dd, J = 8.7, 0.8 Hz, 1 H), 7.80 (d, J = 5.1 Hz, 1 H), 7.48 (dd, J = 1.7, 0.7 Hz, 1 H), 7.28 - 7.03 (m, 2H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.99 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.66 - 3.44 (m, 1 H), 1.30 (d, J = 1 .7 Hz, 6H).
648 1 H NMR (400 MHz, Methanol-d4) δ 8.69 (t, J = 1.1 Hz, 2H), 8.53 (d, J = 2.2 Hz,
1 H), 8.18 (s, 1 H), 7.77 (d, J = 5.1 Hz, 1 H), 7.64 - 7.52 (m, 2H), 7.51 - 7.40 (m, 2H), 7.15 (d, J = 5.1 Hz, 1 H), 4.54 (s, 3H), 4.45 - 4.32 (m, 1 H), 4.16 - 3.88 (m, 1 H), 3.73 - 3.61 (m, 2H), 3.57 - 3.50 (m, 1 H), 3.46 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
649 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 1 .9 Hz, 2H), 8.56 (d, J = 2.2 Hz,
1 H), 8.1 1 (d, J = 2.8 Hz, 1 H), 7.94 - 7.85 (m, 1 H), 7.63 (dd, J = 9.6, 2.8 Hz, 1 H), 7.47 (dt, J = 14.4, 1.7 Hz, 1 H), 7.16 (d, J = 5.1 Hz, 1 H), 6.74 (d, J = 9.7 Hz, 1 H), 6.22 (dt, J = 14.3, 5.5 Hz, 1 H), 4.46 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.26 (dd, J = 5.5, 1.7 Hz, 2H), 3.97 (ddd, J = 36.5, 14.5, 2.1 Hz, 1 H), 3.66 - 3.44 (m, 1 H), 1 .29 (d, J = 1.6 Hz, 6H).
650 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.62 (m, 2H), 8.52 (d, J = 2.2 Hz, 1 H),
7.98 (s, 1 H), 7.75 (d, J = 5.0 Hz, 1 H), 7.39 - 7.25 (m, 2H), 7.14 (d, J = 5.1 Hz, 1 H), 7.06 (d, J = 8.2 Hz, 1 H), 4.46 (ddd, J = 49.0, 9.3, 2.0 Hz, 1 H), 3.98 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.64 (s, 2H), 3.60 - 3.41 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
651 1 H NMR (400 MHz, Methanol-d4) δ 8.82 - 8.66 (m, 2H), 8.52 (d, J = 2.2 Hz, 1 H), compound 1H-NMR
8.02 (s, 1 H), 7.82 (d, J = 5.1 Hz, 1 H), 7.50 - 7.37 (m, 2H), 7.29 (dd, J = 8.6, 2.1 Hz, 1H), 7.15 (d, J =5.1 Hz, 1H), 4.46 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 3.98 (ddd, J = 36.6, 14.6, 2.1 Hz, 1H), 3.53 (ddd, J = 16.2, 14.6, 9.4 Hz, 1H), 1.29 (d, J = 1.6 Hz, 6H).
652 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.0 Hz, 2H), 8.51 (d, J = 2.2 Hz,
1H), 8.13 (s, 1H), 7.78 (d, J = 5.1 Hz, 1H), 7.51 (d, J =7.8 Hz, 1H), 7.23 (d, J = 1.9 Hz, 1 H), 7.22 - 7.09 (m, 2H), 4.47 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 3.99 (ddd, J = 36.6, 14.5, 2.1 Hz, 1H), 3.67-3.42 (m, 1H), 3.24 (s, 3H), 1.41 (s, 6H), 1.30 (d, J = 1.6 Hz, 6H).
653 1 H NMR (400 MHz, Methanol-d4) δ 8.76 - 8.62 (m, 2H), 8.50 (d, J = 2.1 Hz, 1 H),
7.99 (s, 1 H), 7.73 (d, J = 5.0 Hz, 1 H), 7.44 - 7.27 (m, 2H), 7.23 - 7.05 (m, 2H), 4.46 (ddd, J =49.1, 9.2, 2.0 Hz, 1H),
3.99 (dd, J =36.5, 14.6 Hz, 1H), 3.67-3.40 (m, 1 H), 2.03 (s, 1H), 1.39 (s, 6H), 1.30 (d, J = 1.6 Hz, 6H).
654 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 2H), 8.58 (s, 1 H), 7.98 (d, J = 5.1 Hz,
1 H), 7.81 (s, 1 H), 7.65 - 7.49 (m, OH), 7.21 (d, J = 5.1 Hz, 1 H), 4.70 - 4.29 (m, 4H), 3.93 (ddd, J =36.6, 14.5, 2.1 Hz, 1H), 3.63-3.36 (m, 3H), 2.71 -2.38 (m, 2H), 2.28 (td, J = 12.9, 11.1, 8.0 Hz, 2H), 1.29 (d, J = 1.7 Hz, 6H).;1H NMR (400 MHz, Methanol-d4) δ 8.65 - 8.47 (m, 3H), 8.03 (s, 1 H), 7.80 (d, J = 4.9 Hz, 1 H), 7.05 (d, J = 4.9 Hz, 1 H), 4.61 (t, J = 8.7 Hz, 2H), 4.49 (dd, J = 9.2, 2.3 Hz, OH), 4.37 (dd, J = 9.1, 2.3 Hz, 1H), 4.19 (t, J =7.4 Hz, 1H), 4.04-3.82 (m, 1H), 3.65 (s, OH), 3.57- 3.46 (m, 1 H), 3.38 (d, J = 7.5 Hz, 2H), 2.52 (s, 1 H), 2.41 (tt, J = 7.8, 3.1 Hz, 2H), 2.14 (q, J = 9.5 Hz, 2H), 1.29 (d, J = 1.7 Hz, 6H).
655 1 H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.70 (m, 2H), 8.57 (s, 1 H), 8.48 (d, J =
6.2 Hz, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.79 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.58 - 4.32 (m, 2H), 3.93 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.62 - 3.40 (m, 3H), 3.21 (q, J = 10.8 Hz, 2H), 2.70 - 2.42 (m, 3H), 2.29 (ddd, J = 12.5, 9.3, 7.0 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
656 1 H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.69 (m, 2H), 8.57 (s, 1 H), 8.36 (s, 1 H),
7.98 (d, J = 5.1 Hz, 1 H), 7.77 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 6.22 (tt, J = 56.1 , 4.8 Hz, 1 H), 4.60 - 4.30 (m, 2H), 3.94 (ddd, J = 36.5, 14.5, 2.1 Hz, 1 H), 3.65 - 3.41 (m, 3H), 2.86 (td, J = 16.5, 4.8 Hz, 2H), 2.69-2.23 (m, 5H), 1.29 (d, J = 1.7 Hz, 6H).
657 1 H NMR (400 MHz, Methanol-d4) δ 8.80 - 8.70 (m, 2H), 8.58 (d, J = 2.2 Hz, 1 H),
8.08 (dd, J = 2.5, 0.7 Hz, 1 H), 8.04 - 7.83 (m, 3H), 7.25 - 7.11 (m, 2H), 4.46 (ddd, J = 49.1, 9.3, 2.1 Hz, 1H), 3.97 (ddd, J =36.5, 14.6, 2.1 Hz, 1H), 3.66-3.45 (m, 1H), 1.29 (d, J = 1.7 Hz, 6H).
658 1 H NMR (400 MHz, Methanol-d4) δ 8.76 - 8.65 (m, 2H), 8.56 (d, J = 2.2 Hz, 1 H),
8.38 (s, 2H), 7.96-7.69 (m, 2H), 7.16 (d, J =5.1 Hz, 1H), 4.46 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 3.98 (ddd, J = 36.6,
14.6, 2.1 Hz, 1H), 3.68-3.44 (m, 1H), 1.29 (d, J = 1.7 Hz, 6H).
659 1 H NMR (400 MHz, Methanol-d4) δ 8.82 - 8.69 (m, 2H), 8.57 (s, 1 H), 7.99 (d, J =
5.1 Hz, 1 H), 7.76 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.73 - 4.31 (m, 2H), 3.93 (ddd, J = 36.4, 14.5, 2.2 Hz, 1H), 3.65-3.38 (m, 3H), 2.69-2.39 (m, 3H), 2.29 (dt, J = 15.4, 9.7 Hz, 2H), 2.17-2.01 (m, 1H), 1.49 -1.36 (m, OH), 1.29 (d, J = 1.6 Hz, 6H), 1.26- 1.19 (m, 1H).
660 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.63 (m, 2H), 8.49 (d, J = 2.2 Hz, 1 H),
8.23 (s, 1 H), 7.92 (dd, J = 8.5, 0.8 Hz, 1 H), 7.74 (d, J = 5.1 Hz, 1 H), 7.59 (dd, J = 1.8, 0.7 Hz, 1H), 7.26-7.09 (m, 2H), 4.47 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 4.13- 3.83 (m, 1 H), 3.65 - 3.46 (m, 1 H), 2.61 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
661 1 H NMR (400 MHz, Methanol-d4) δ 8.82 - 8.67 (m, 2H), 8.58 (d, J = 2.1 Hz, 1 H),
8.07 (dd, J = 2.4, 0.7 Hz, 1 H), 8.01 - 7.81 (m, 3H), 7.28 - 7.03 (m, 2H), 4.46 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 3.97 (ddd, J =36.4, 14.5, 2.1 Hz, 1H), 3.69-3.42 (m, 1H),
3.08 (s, 3H), 1.29 (d, J = 1.7 Hz, 6H).
662 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.66 (m, 2H), 8.54 (d, J = 2.2 Hz, 1 H),
8.42 (dd, J = 2.7, 0.8 Hz, 1 H), 8.28 (d, J = 8.9 Hz, 1 H), 8.05 (s, 1 H), 7.90 (dd, J = 8.9, 2.7 Hz, 1H), 7.81 (d, J = 5.1
Hz, 1H), 7.15 (d, J = 5.1 Hz, 1H), 4.47 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 3.99 (ddd, J = 36.5, 14.5, 2.1 Hz, 1H), 3.67-3.46 (m, 1H), 2.22 (s, 3H), 1.30 (d, J = 1.7 Hz, 6H).
663 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.68 (m, 3H), 8.57 (d, J = 2.2 Hz, 1 H),
7.94 (s, 1H), 7.87 (d, J =5.1 Hz, 1H), 7.15 (d, J =5.1 Hz, 1H), 4.68-4.58 (m, 2H), 4.59-4.35 (m, 1H), 3.99 (ddd, J
= 36.4, 14.5, 2.1 Hz, 1H), 3.90-3.77 (m, 2H), 3.62-3.38 (m, 4H), 1.30 (d, J = 1.6 Hz, 6H), 1.26 (d, J = 1.8 Hz, 1H).
664 1 H NMR (400 MHz, Methanol-d4) δ 8.98 (s, OH), 8.82 - 8.63 (m, 3H), 8.58 (dd, J =
6.0, 2.1 Hz, 1H), 8.20 (s, 1H), 8.17-8.00 (m, 1H), 7.83 (t, J =6.7 Hz, 2H), 7.16 (d, J =5.1 Hz, 1H), 5.48 (s, OH),
4.47 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 4.16-3.87 (m, 2H), 3.69-3.41 (m, 1H), 1.30 compound 1H-NMR
(d, J = 1.6 Hz, 6H).
665 1 H NMR (400 MHz, Methanol-d4) δ 8.75 - 8.60 (m, 2H), 8.45 (dd, J = 22.3, 2.2 Hz,
1H), 8.01 (d, J = 19.2 Hz, 1H), 7.79-7.64 (m, 2H), 7.42-7.29 (m, 1H), 7.20-7.01 (m, 2H), 4.47 (dd, J =49.0,8.3
Hz, 1H), 3.99 (dd, J = 36.6, 14.8 Hz, 1H), 3.65-3.39 (m, 1H), 2.28 (d, J =7.6 Hz, 2H), 1.30 (d, J = 1.7 Hz, 6H).
666 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 5.5 Hz, 3H), 8.71 (d, J = 2.2 Hz,
1H), 8.57 (d, J =2.2 Hz, 1H), 8.02 (s, 1H), 7.86 (d, J =5.1 Hz, 1H), 7.16 (d, J =5.1 Hz, 1H), 4.46 (ddd, J =49.1, 9.3, 2.1 Hz, 1H), 3.98 (ddd, J =36.5, 14.5, 2.1 Hz, 1H), 3.53 (ddd, J = 16.3, 14.6, 9.4 Hz, 1H), 2.34 (tt, J = 7.4, 5.4 Hz, 1H), 1.29 (d, J = 1.6 Hz, 6H), 1.25-1.12 (m, 4H).
667 1 H NMR (400 MHz, Methanol-d4) δ 9.68 (s, 1 H), 8.70 (d, J = 2.5 Hz, 2H), 8.64 (d,
J = 2.2 Hz, 1 H), 8.22 (d, J = 3.0 Hz, 1 H), 7.85 (d, J = 5.0 Hz, 1 H), 7.50 (dd, J = 8.9, 3.0 Hz, 1H), 7.28-7.13 (m, 3H), 4.47 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 3.93 (s, 5H), 3.60-3.45 (m, 1H), 1.31 (s, 6H).
668 1 H NMR (400 MHz, Methanol-d4) δ 8.70 (d, J = 2.0 Hz, 2H), 8.57 (d, J = 2.1 Hz,
1 H), 8.20 (d, J = 2.3 Hz, 1 H), 7.91 (s, 1 H), 7.82 (d, J = 5.1 Hz, 1 H), 7.70 (dd, J = 2.3, 1.2 Hz, 1 H), 7.15 (d, J = 5.1 Hz, 1 H), 4.46 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 3.99 (ddd, J =36.5, 14.5, 2.1 Hz, 1H), 3.71 (t, J = 1.0 Hz, 1H), 3.65-3.45 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
669 1 H NMR (400 MHz, Methanol-d4) δ 8.75 - 8.64 (m, 2H), 8.54 (d, J = 2.1 Hz, 1 H),
8.40 (s, 2H), 7.91 -7.73 (m, 2H), 7.15 (d, J =5.1 Hz, 1H), 4.46 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 3.98 (ddd, J = 36.5,
14.5, 2.1 Hz, 1H), 3.52 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 3.26 (s, 6H), 1.29 (d, J = 1.7 Hz, 6H).
670 1 H NMR (400 MHz, Methanol-d4) δ 8.86 (s, 1 H), 8.62 (d, J = 2.2 Hz, 1 H), 8.36 (d,
J =2.1 Hz, 1H), 7.42 (dd, J = 9.3, 2.2 Hz, 1H), 7.35-7.17 (m, 2H), 7.08 (d, J =4.7 Hz, 1H), 6.81 (dd, J = 9.3, 0.8
Hz, 1 H), 6.69 (s, 1 H), 5.08 (s, 2H), 4.37 (ddd, J = 49.0, 9.2, 2.5 Hz, 1 H), 3.98 (ddd, J =35.5, 14.4, 2.5 Hz, 1H), 3.64-3.45 (m, 1H), 1.27 (d, J = 1.7 Hz, 6H).
671 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.70 (t, J = 1.8 Hz, 2H), 8.59 (d, J
= 2.2 Hz, 1H), 8.21 (s, 1H), 8.13 (dd, J = 8.5, 2.5 Hz, 1H), 7.90-7.81 (m, 2H), 7.16 (d, J =5.1 Hz, 1H), 4.47 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 3.99 (ddd, J = 36.5, 14.5, 2.1 Hz, 1H), 3.54 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
672 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.0 Hz, 2H), 8.73 - 8.63 (m, 3H),
8.08 (d, J = 5.1 Hz, 1 H), 8.02 (d, J = 8.8 Hz, 2H), 7.23 (d, J = 5.1 Hz, 1 H), 5.06 (tt, J =7.4, 5.0 Hz, 1H), 4.38 (ddd,
J = 49.0, 9.4, 2.1 Hz, 1 H), 4.06 - 3.78 (m, 3H), 3.60 - 3.34 (m, 3H), 1.25 (d, J = 1.6 Hz, 6H).
673 1 H NMR (400 MHz, Methanol-d4) δ 8.77 - 8.66 (m, 2H), 8.55 (d, J = 2.2 Hz, 1 H),
8.22 (dd, J =2.7, 0.7 Hz, 1H), 7.92 (s, 1H), 7.86-7.66 (m, 2H), 7.19-7.03 (m, 2H), 4.46 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 3.98 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.89 - 3.76 (m, 4H), 3.67 - 3.57 (m, 4H), 3.57 - 3.43 (m, 1 H), 1.29 (d, J = 1.6 Hz, 6H).
674 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.67 (m, 3H), 8.66 - 8.54 (m, 1 H), 8.37
(s, OH), 8.04 (s, 1H), 7.88 (d, J =5.2 Hz, 1H), 7.16 (d, J =5.1 Hz, 1H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 3.99 (ddd, J =36.3, 14.6, 2.1 Hz, 1H), 3.65-3.40 (m, 1H), 2.29 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
675 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.69 (m, 2H), 8.59 (d, J = 2.2 Hz, 1 H),
8.09 (dd, J =2.5, 0.8 Hz, 1H), 7.99-7.78 (m, 3H), 7.16 (d, J =5.1 Hz, 1H), 6.87 (dd, J = 9.4, 0.8 Hz, 1H), 4.52 (dd,
J =9.3, 2.2 Hz, 1H), 4.41 -4.20 (m, 5H), 3.97 (ddd, J =36.3, 14.6, 2.1 Hz, 1H), 3.53 (ddd, J = 16.1, 14.6, 9.4 Hz, 1H), 2.58 (p, J =7.6 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
676 1 H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.73 (m, 2H), 8.72 - 8.59 (m, 3H), 8.06
(d, J = 5.1 Hz, 1 H), 8.04 - 7.92 (m, 2H), 7.23 (d, J = 5.1 Hz, 1 H), 5.04 (tt, J = 7.4, 5.0 Hz, 1H), 4.38 (ddd, J = 49.0,
9.3, 2.1 Hz, 1 H), 4.01 - 3.73 (m, 3H), 3.58 - 3.35 (m, 3H), 1.25 (d, J = 1.7 Hz, 6H).;1 H NMR (400 MHz, Methanol-d4) δ 8.84 - 8.71 (m, 2H), 8.71 - 8.58 (m, 3H), 8.15 - 7.88 (m, 3H), 7.23 (d, J = 5.0 Hz
, 1H), 5.03 (ddd, J = 12.3, 7.4, 5.0 Hz, 1H), 4.38 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 4.03 - 3.73 (m, 3H), 3.60 - 3.33 (m, 3H), 1.25 (d, J = 1.6 Hz, 6H).
677 1H NMR (400 MHz, Methanol-d4) δ 8.84 - 8.71 (m, 2H), 8.71 -8.58 (m, 3H), 8.15- 7.88 (m, 3H), 7.23 (d, J = 5.0 Hz, 1 H), 5.03 (ddd, J = 12.3, 7.4, 5.0 Hz, 1 H), 4.38 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.03 - 3.73 (m, 3H), 3.60 - 3.33 (m, 3H), 1.25 (d, J = 1.6 Hz, 6H).
678 1 H NMR (400 MHz, Methanol-d4) δ 8.80 - 8.66 (m, 2H), 8.58 (d, J = 2.2 Hz, 1 H),
8.17 (s, 1H), 7.99 (dd, J =8.4, 2.6 Hz, 1H), 7.84 (d, J = 5.1 Hz, 1H), 7.69 (dd, J = 8.4, 0.8 Hz, 1H), 7.16 (d, J = 5.1 compound 1H-NMR
Hz, 1 H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.99 (ddd, J = 36.4, 14.5, 2.1 Hz, 1H), 3.54 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
679 1 H NMR (400 MHz, Methanol-d4) δ 8.70 (d, J = 2.1 Hz, 2H), 8.56 (d, J = 2.2 Hz,
1H), 8.12 (dd, J =2.7, 0.7 Hz, 1H), 7.93 (s, 1H), 7.92-7.77 (m, 2H), 7.24-7.05 (m, 2H), 4.46 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 3.97 (ddd, J =36.3, 14.6, 2.1 Hz, 1 H), 3.63 - 3.45 (m, 1 H), 3.26 (s, 6H), 1.30 (d, J = 1.6 Hz, 6H).
680 1 H NMR (400 MHz, Methanol-d4) δ 8.88 (s, 2H), 8.78 (s, 1 H), 8.70 (d, J = 2.1 Hz,
1H), 8.58 (d, J =2.1 Hz, 1H), 8.10 (s, 1H), 7.87 (d, J =5.1 Hz, 1H), 7.15 (d, J =5.1 Hz, 1 H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.98 (ddd, J = 36.4, 14.6, 2.1 Hz, 1H), 3.55 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 3.07 (q, J = 7.6 Hz, 2H), 1.42 (t, J =7.6 Hz, 3H), 1.30 (d, J = 1.7 Hz, 6H).
681 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.65 (m, 2H), 8.57 (d, J = 2.2 Hz, 1 H),
8.40 (s, 2H), 7.93-7.79 (m, 2H), 7.15 (d, J =5.1 Hz, 1H), 4.46 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 4.23 (t, J =7.6 Hz,
4H), 3.98 (ddd, J = 36.5, 14.5, 2.1 Hz, 1H), 3.52 (ddd, J = 16.2, 14.5, 9.3 Hz, 1H), 2.65 (s, 1 H), 2.45 (p, J = 7.6 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
682 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.62 (m, 2H), 8.57 (d, J = 2.1 Hz, 1 H),
8.22 (dd, J =2.6, 0.7 Hz, 1H), 7.90 (s, 1H), 7.86-7.63 (m, 2H), 7.15 (d, J =5.1 Hz, 1 H), 6.79 (dd, J = 8.9, 0.8 Hz, 1 H), 4.62 - 4.34 (m, 5H), 3.98 (ddd, J = 36.5, 14.5, 2.1 Hz, 1H), 3.52 (ddd, J = 16.3, 14.6, 9.4 Hz, 1H), 1.29 (d, J = 1.7 Hz, 6H).
683 1 H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.67 (m, 3H), 8.56 (d, J = 2.2 Hz, 1 H),
8.16 (s, 1H), 8.00 (dd, J =8.5, 2.6 Hz, 1H), 7.91 -7.77 (m, 2H), 7.16 (d, J =5.1 Hz, 1 H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.99 (ddd, J = 36.4, 14.5, 2.1 Hz, 1 H), 3.70 - 3.44 (m, 1 H), 1.83 (s, 6H), 1.30 (d, J = 1.6 Hz, 6H).
684 1 H NMR (400 MHz, Methanol-d4) δ 8.82 - 8.69 (m, 2H), 8.59 (d, J = 2.2 Hz, 1 H),
8.24-8.07 (m, 1H), 7.96-7.90 (m, 2H), 7.85 (dd, J = 5.1, 1.9 Hz, 1H), 7.16 (d, J = 5.1 Hz, 1H), 6.90 (dt, J = 9.3, 1.1 Hz, 1H), 4.61 -4.37 (m, 5H), 4.15 (q, J = 9.2 Hz, 1H), 4.12-3.78 (m, 1H), 3.53 (ddd, J = 16.0, 14.5, 9.4 Hz, 1H), 1.29 (d, J = 1.6 Hz, 6H).
685 1 H NMR (400 MHz, Methanol-d4) δ 8.76 - 8.63 (m, 2H), 8.53 (d, J = 2.2 Hz, 1 H),
8.13 (s, 1H), 7.77 (d, J =5.1 Hz, 1H), 7.27-7.16 (m, 2H), 7.06 (d, J = 7.7 Hz, 2H), 4.46 (ddd, J =49.0, 9.3, 2.1 Hz,
1H), 4.03 (dd, J = 14.6, 2.1 Hz, 1H), 3.90 (d, J =8.1 Hz, 8H), 3.53 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 3.22-3.11 (m, 4H), 1.30 (d, J = 1.7 Hz, 6H).
686 1 H NMR (400 MHz, Methanol-d4) δ 8.77 - 8.62 (m, 2H), 8.53 (d, J = 2.2 Hz, 1 H),
8.43 (s, 2H), 7.83 (d, J =5.0 Hz, 2H), 7.14 (d, J =5.1 Hz, 1H), 4.74-4.60 (m, 2H), 4.46 (ddd, J =49.0, 9.3, 2.1 Hz,
1 H), 3.97 (ddd, J = 36.4, 14.5, 2.1 Hz, 1 H), 3.66 (dtd, J = 12.5, 6.2, 2.4 Hz, 2H), 3.53 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 2.65 (dd, J = 13.3, 10.6 Hz, 2H), 1.29 (d, J = 1.7 Hz, 6H), 1.24 (d, J =6.2
Hz, 6H).
687 1 H NMR (400 MHz, Methanol-d4) δ 9.90 (s, 1 H), 8.82 - 8.66 (m, 3H), 8.47 (d, J =
3.1 Hz, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.72 (ddd, J = 9.0, 7.9, 3.0 Hz, 1 H), 7.29 (dd, J =9.0, 3.6 Hz, 1H), 7.20 (d, J
= 5.0 Hz, 1 H), 4.47 (ddd, J = 49.0, 9.3, 2.2 Hz, 1 H), 3.99 (ddd, J = 36.2, 14.5, 2.2 Hz, 1 H), 3.70 - 3.42 (m, 1 H), 1.31 (d, J = 1.6 Hz, 6H).
688 1 H NMR (400 MHz, Methanol-d4) δ 8.70 (d, J = 2.2 Hz, 1 H), 8.65 (s, 1 H), 8.56 (d,
J = 2.2 Hz, 1 H), 8.03 (s, 1 H), 7.74 (d, J = 5.1 Hz, 1 H), 7.45 - 7.31 (m, 2H), 7.31 - 7.21 (m, 2H), 7.15 (d, J = 5.0 Hz, 1H), 4.46 (ddd, J = 48.9, 9.3, 2.1 Hz, 1H), 4.15 - 3.87 (m, 2H), 3.52 (td, J = 15.4, 9.3 Hz, 1H), 3.24-3.12 (m, 4H), 1.30 (d, J = 1.6 Hz, 6H).
689 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.64 (m, 2H), 8.56 (d, J = 2.1 Hz, 1 H),
8.42 (s, 2H), 7.84 (d, J =5.4 Hz, 2H), 7.15 (d, J =5.1 Hz, 1H), 4.46 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 3.97 (s, 5H), 3.69 (t, J =5.3 Hz, 4H), 3.52 (ddd, J = 16.2, 14.5, 9.3 Hz, 1 H), 1.87 (t, J = 5.3 Hz, 4H), 1.29 (d, J = 1.6 Hz, 6H).
690 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.95 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 4.11 (d, J = 12.1 Hz, 2H), 4.04-3.81 (m, 4H), 3.61 -3.41 (m, 3H), 3.25 (d, J = 12.8 Hz, 2H), 2.26 (d, J = 13.1 Hz, 2H), 2.20-1.97 (m, 4H), 1.75 (qd, J = 12.9, 3.9 Hz, 2H), 1.53 (s, 3H), 1.28 (d, J = 1.7 Hz, 6H).
691 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.71 - 8.64 (m, 2H),
8.02 (t, J = 5.1 Hz, 1 H), 7.89 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (dddd, J = 49.1 , 9.4, 4.6, 2.1 Hz, 1 H), 4.32 - 4.03 (m, 3H), 4.03 - 3.74 (m, 3H), 3.70 - 3.43 (m, 3H), 2.30 - 1.85 (m, 8H), 1.77 (t, J = 11.0 Hz, OH), 1.53 (s, 3H), 1.29 (dd, J = 3.0, 1.6 Hz, 6H).
692 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.1 Hz,
1 H), 8.62 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.67 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.59 - 4.29 (m, 2H), 3.92 (ddd, J =
36.4, 14.7, 2.1 Hz, 1H), 3.51 (ddd, J = 16.0, 14.5, 9.4 Hz, 1H), 3.22 (d, J =7.9 Hz, compound 1 H-NMR
2H), 2.74 (tt, J = 8.8, 4.5 Hz, 1 H), 2.55 (ddd, J = 12.7, 7.4, 4.3 Hz, 2H), 2.41 (ddd, J = 13.2, 9.2, 6.4 Hz, 2H),
1.29 (d, J = 1 .6 Hz, 6H).
693 1 H NMR (400 MHz, Methanol-d4) δ 9.1 1 (s, 1 H), 8.87 (s, 1 H), 8.58 (d, J = 2.2 Hz,
1 H), 8.55 (d, J = 2.2 Hz, 1 H), 8.50 (d, J = 2.3 Hz, 1 H), 8.31 (d, J = 2.2 Hz, 1 H), 7.96 (d, J = 4.9 Hz, 1 H), 7.46 (d, J = 4.7 Hz, 1 H), 7.11 (t, J = 4.9 Hz, 2H), 4.19 (dd, J = 48.6, 9.3 Hz, 1 H), 3.88 - 3.57 (m, 2H), 1 .21 (d, J = 1.6 Hz, 6H).
694 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.74 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.58 - 4.31 (m, 2H), 3.93 (ddd, J =
36.5, 14.6, 2.1 Hz, 1 H), 3.57 - 3.36 (m, 3H), 2.76 - 2.61 (m, 1 H), 2.50 (ddd, J = 12.4, 7.4, 3.6 Hz, 2H), 2.38 (s, 3H), 2.37 - 2.23 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
695 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (br s, 2H), 8.57 (s, 1 H), 8.46 (br t, 1 H),
7.98 (d, J = 5.1 Hz, 1 H), 7.83 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.53 - 4.30 (m, 2H), 4.06 - 3.78 (m, 1 H), 3.65 - 3.35
(m, 3H), 2.63 - 2.38 (m, 4H), 2.29 (ddd, J = 20.0, 13.4, 7.8 Hz, 2H), 2.05 (dt, J = 13.5, 7.1 Hz, 1 H), 1.84 - 1 .68 (m, 1 H), 1.29 (d, J = 1.6 Hz, 6H).
696 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.73 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.56 - 4.31 (m, 2H), 3.94 (dd, J = 36.6, 14.5 Hz, 1 H), 3.49 (d, J = 7.8 Hz, 3H), 2.68 (d, J = 10.6 Hz, 1 H), 2.48 (d, J = 8.7 Hz, 2H), 2.32 (q, J = 10.3, 9.7 Hz, 2H), 2.12 - 1 .98 (m, 1 H), 1.29 (d, J = 1.6 Hz, 6H), 1.14 - 1.03 (m, 2H), 1 .03 - 0.94 (m, 2H).
697 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.75 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.58 - 4.30 (m, 4H), 3.94 (dd, J = 36.8, 14.8 Hz, 1 H), 3.54 (d, J = 7.6 Hz, 2H), 3.52 - 3.41 (m, 1 H), 3.39 (s, 2H), 2.77 - 2.63 (m, 1 H), 2.51 (t, J = 9.7 Hz, 2H), 2.33 (q, J = 10.5, 9.8 Hz, 2H), 1 .29 (d, J = 1.6 Hz, 6H).
698 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 7.97 (d, J = 5.1 Hz, 1 H), 7.74 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.54 - 4.31 (m, 1 H), 4.23 (t, J = 8.0 Hz, 1 H), 4.04 - 3.82 (m, 1 H), 3.62 (s, 3H), 3.56 - 3.36 (m, 1 H), 3.19 (d, J = 6.4 Hz, 2H), 2.71 (t, J = 9.6 Hz, 2H), 2.41 (d, J = 9.0 Hz, 1 H), 1 .86 (t, J = 10.1 Hz, 2H), 1 .29 (d, J = 1 .6 Hz, 6H).
699 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 2H), 8.56 (s, 1 H), 8.49 - 8.37 (m, 1 H),
7.97 (d, J = 5.1 Hz, 1 H), 7.83 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.54 - 4.30 (m, 2H), 3.94 (dd, J = 36.5, 14.6 Hz, 1 H), 3.65 - 3.34 (m, 3H), 2.66 - 2.36 (m, 4H), 2.38 - 2.17 (m, 2H), 2.15 - 1.90 (m, 1 H), 1.87 - 1.70 (m, 1 H), 1.29 (d, J = 1.6 Hz, 6H).
700 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.61 (d, J = 4.8 Hz, 1 H), 8.02 - 7.95 (m, 1 H), 7.77 (s, 1 H), 7.64 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.52 - 4.32 (m, 2H), 3.94 (qd, J = 9.1 , 4.0 Hz, 3H), 3.59 - 3.41 (m, 1 H), 3.40 - 3.33 (m, 1 H), 3.25 (d, J = 7.0 Hz, 1 H), 2.88 (d, J = 15.4 Hz, 1 H), 2.67 - 2.51 (m, 2H), 2.51 - 2.35 (m, 1 H), 1.99 (q, J = 10.0, 8.3 Hz, 1 H), 1.29 (t, J = 1 .5 Hz, 6H).
701 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.3 Hz,
1 H), 8.61 (d, J = 6.2 Hz, 1 H), 7.98 (dd, J = 5.1 , 2.3 Hz, 1 H), 7.78 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.54 - 4.26 (m, 2H), 4.18 - 3.99 (m, 2H), 4.01 - 3.83 (m, 1 H), 3.84 - 3.67 (m, 2H), 3.59 - 3.38 (m, 3H), 3.33 (d, J = 7.1 Hz, 2H), 3.24 - 3.07 (m, 1 H), 3.02 - 2.81 (m, 2H), 2.77 - 2.38 (m, 2H), 2.03 (m, 2H), 1.29 (t, J = 1 .5 Hz, 6H).
702 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.1 Hz, 1 H), 8.69 (s, 1 H), 8.64 (s,
1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.70 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.97 (t, J = 7.5 Hz, 1 H), 4.72 (dd, J = 8.1 , 5.2 Hz, 1 H), 4.57 - 4.36 (m, 3H), 4.07 - 3.84 (m, 2H), 3.72 - 3.39 (m, 2H), 3.29 (d, J = 8.0 Hz, 2H), 2.83 (d, J = 5.3 Hz, 1 H), 2.67 - 2.39 (m, 4H), 1.32 (d, J = 1 .6 Hz, 6H).
703 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.1 Hz,
1 H), 8.55 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.81 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.58 - 4.23 (m, 1 H), 3.92 (dd, J = 35.7, 14.7 Hz, 1 H), 3.58 (d, J = 7.2 Hz, 2H), 3.49 (td, J = 15.3, 9.4 Hz, 1 H), 2.78 (p, J = 7.6 Hz, 1 H), 2.20 (dt, J = 12.1 , 7.3 Hz, 2H), 2.06 - 1.94 (m, 3H), 1.98 - 1.84 (m, 2H), 1.28 (d, J = 1 .7 Hz, 6H).
704 1 H NMR (400 MHz, Acetonitrile-d3) δ 8.68 (s, 1 H), 8.60 (d, J = 1.9 Hz, 2H), 8.07
(d, J = 5.3 Hz, 1 H), 7.54 (d, J = 6.4 Hz, 2H), 7.18 (d, J = 5.1 Hz, 1 H), 4.52 (d, J = 7.6 Hz, 2H), 4.42 - 4.21 (m, 1 H), 3.61 - 3.39 (m, 1 H), 1.27 (m, 7H), 1.02 - 0.87 (m, 2H), 0.87 - 0.70 (m, 2H).
705 1 H NMR (400 MHz, Acetonitrile-d3) δ 8.69 (s, 1 H), 8.62 (s, 1 H), 8.48 (s, 1 H), 8.05
(s, 1 H), 7.41 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.41 (dd, J = 8.8, 3.1 Hz, 1 H), 4.09 - 3.91 (m, 2H), 3.64 (s, 3H), 3.34 (s, 3H), 2.47 - 2.39 (m, 5H), 1.84 - 1.74 (m, 1 H), 1.35 (s, 7H).
706 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.1 Hz, 1 H), 8.69 (s, 1 H), 8.59 (s,
1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.67 (s, 1 H), 7.24 (d, J = 5.2 Hz, 1 H), 6.96 (d, J = 4.6 Hz, 1 H), 4.57 - 4.35 (m, 2H), 4.07 - 3.87 (m, 1 H), 3.59 (d, J = 6.5 Hz, 2H), 3.45 (s, compound 1 H-NMR
3H), 3.16 (s, 1 H), 2.77 - 2.65 (m, 1 H), 2.54 (d, J = 11 .7 Hz, 2H), 2.33 (d, J = 13.6 Hz, 2H), 1 .33 - 1.31 (m, 10H).
707 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.1 Hz, 1 H), 8.68 (d, J = 2.1 Hz,
1 H), 8.53 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.71 (s, 1 H), 7.36 (dd, J = 8.3, 5.4 Hz, 2H), 7.23 (d, J = 5.1 Hz, 1 H), 7.02 (t, J = 8.8 Hz, 2H), 4.60 - 4.22 (m, 1 H), 4.03 - 3.87 (m, 1 H), 3.86 (t, J = 7.1 Hz, 2H), 3.50 (td, J = 15.4, 9.5 Hz, 1 H), 3.09 (t, J = 6.8 Hz, 2H), 1.32 (d, J = 1 .7 Hz, 6H).
708 1 H NMR (400 MHz, DMSO-d6) δ 8.82 (d, J = 2.3 Hz, 1 H), 8.79 - 8.69 (m, 3H), 8.61
(d, J = 2.3 Hz, 1 H), 7.94 (s, 1 H), 7.86 (d, J = 4.7 Hz, 1 H), 7.30 (t, J = 7.8 Hz, 2H), 7.10 (d, J = 4.8 Hz, 1 H), 6.96 (t, J = 7.4 Hz, 1 H), 6.90 (d, J = 8.2 Hz, 2H), 4.98 (dq, J = 1 1.9, 5.9, 5.4 Hz, 1 H), 4.54 - 4.29 (m, 1 H), 4.23 (dt, J = 9.1 , 4.3 Hz, 1 H), 3.84 - 3.66 (m, 1 H), 3.43 (dp, J = 14.8, 7.3 Hz, 1 H), 2.68 (td,
J = 10.4, 7.8, 4.3 Hz, 2H), 2.57 (q, J = 6.2 Hz, 2H), 1.23 - 1.16 (m, 6H).
709 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.32 (s, 1 H), 7.96 (d, J = 5.0 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 3.79 (d, J = 21.7 Hz, 2H), 2.28 (t,
J = 7.9 Hz, 6H), 1.93 (t, J = 8.0 Hz, 6H), 1.10 (d, J = 18.6 Hz, 2H), 0.86 (d, J = 7.9 Hz, 2H).
710 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.1 Hz,
1 H), 8.57 (s, 1 H), 8.31 (s, 1 H), 7.96 (d, J = 5.0 Hz, 1 H), 7.25 (d, J = 5.0 Hz, 1 H), 6.24 (t, J = 55.8 Hz, 1 H), 4.73 (d,
J = 6.9 Hz, 2H), 4.61 (d, J = 6.9 Hz, 2H), 3.85 (s, 2H), 2.28 (t, J = 8.0 Hz, 6H), 1.94 (t, J = 7.5 Hz, 6H).
711 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (s, 1 H), 8.72 (d, J = 7.4 Hz, 1 H), 8.58 (d,
J = 18.1 Hz, 1 H), 8.30 (s, 1 H), 7.96 (d, J = 5.0 Hz, 1 H), 7.25 (d, J = 4.9 Hz, 1 H), 4.61 - 4.49 (m, 4H), 3.82 (s, 2H),
3.72 (s, 2H), 3.58 (s, 1 H), 2.27 (d, J = 8.5 Hz, 6H), 1.94 (d, J = 8.4 Hz, 6H).
712 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.02 (d, J = 5.0 Hz, 1 H), 7.86 (s, 1 H), 7.23 (d, J = 5.0 Hz, 1 H), 4.18 (p, J = 6.4 Hz, 1 H), 4.07 (d, J = 8.9 Hz, 1 H), 3.61 (t, J = 7.1 Hz, 2H), 2.12 - 1 .98 (m, 1 H), 1.88 (dq, J = 16.9, 6.5 Hz, 1 H), 1.43 (d, J = 6.3 Hz, 6H).
713 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.3 Hz,
1 H), 8.55 (s, 1 H), 8.03 (d, J = 4.8 Hz, 1 H), 7.82 (d, J = 6.3 Hz, 1 H), 7.23 (d, J = 5.0 Hz, 1 H), 4.45 (dd, J = 49.1 , 9.1
Hz, 1 H), 3.96 (dd, J = 36.8, 14.7 Hz, 1 H), 3.77 - 3.36 (m, 5H), 3.37 (s, 3H), 2.50 (dq, J = 38.8, 7.7 Hz, 2H), 2.08 (dt, J = 38.6, 9.3 Hz, 2H), 1.80 (ddt, J = 36.1 , 18.7, 9.3 Hz, 2H), 1.31 (s, 6H).
714 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (q, J = 2.2 Hz, 2H), 8.58 (s, 1 H), 8.00 (d,
J = 5.1 Hz, 1 H), 7.80 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.63 - 4.44 (m, 1 H), 4.42 - 4.29 (m, 3H), 3.93 (ddd, J = 36.6, 14.6, 2.1 Hz, 1 H), 3.70 - 3.57 (m, 2H), 3.56 - 3.38 (m, 3H), 2.73 (pt, J = 8.2, 3.9 Hz, 1 H), 2.57 - 2.40 (m, 2H), 2.31 (dddd, J = 1 1.3, 9.2, 7.1 , 2.4 Hz, 2H), 1 .29 (d, J = 1.6 Hz, 6H).
715 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 8.02 (d, J = 5.0 Hz, 1 H), 7.88 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.56 - 4.25 (m, 3H), 4.08 - 3.72 (m, 2H), 3.71 - 3.59 (m, 2H), 3.48 (ddd, J = 16.0, 14.6, 9.4 Hz, 1 H), 3.17 (d, J = 7.3 Hz, 2H), 2.22 (d, J = 12.5 Hz, 2H), 1 .88 (m, 2H), 1 .76 (tt, J = 7.7, 3.8 Hz, 1 H), 1.58 - 1.39 (m, 2H), 1.28 (d, J = 1 .6 Hz, 8H).
716 1 H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 2.2 Hz, 1 H), 8.63 (d, J = 2.2 Hz,
1 H), 8.52 (s, 1 H), 7.95 (d, J = 5.0 Hz, 1 H), 7.88 (s, 1 H), 7.17 (d, J = 5.0 Hz, 1 H), 4.43 (ddd, J = 49.0, 9.3, 2.2 Hz, 1 H), 3.92 (ddd, J = 36.3, 14.5, 2.2 Hz, 1 H), 3.60 (s, 3H), 3.58 - 3.41 (m, 3H), 3.29 - 3.16 (m, 2H), 1.93 (p, J = 6.8 Hz, 2H), 1.28 (d, J = 1.6 Hz, 6H).
717 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.86 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.92 (ddd, J = 36.4, 14.5, 2.1 Hz, 1 H), 3.72 - 3.38 (m, 6H), 3.18 (t, J = 6.8 Hz, 2H), 1 .93 - 1.74 (m, 2H), 1.66 (p, J = 6.9 Hz, 2H), 1 .28 (d, J = 1.7 Hz, 6H).
718 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.00 (d, J = 5.0 Hz, 1 H), 7.89 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.45 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 3.95 (ddd, J = 36.4, 14.6, 2.2 Hz, 1 H), 3.58 (s, 4H), 3.39 (s, 2H), 3.10 (s, 2H), 1.35 - 1.24 (m, 6H), 1.05 (s, 6H).
719 1 H NMR (400 MHz, Methanol-d4) δ 8.80 - 8.59 (m, 2H), 8.42 (d, J = 2.2 Hz, 1 H),
8.21 (s, 1 H), 7.94 - 7.67 (m, 2H), 7.67 - 7.52 (m, 3H), 7.47 - 7.36 (m, 2H), 7.15 (d, J = 5.1 Hz, 1 H), 6.72 - 6.56 (m, 1 H), 6.46 (td, J = 6.7, 1.4 Hz, 1 H), 5.28 (s, 2H), 4.46 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.98 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.66 - 3.40 (m, 1 H), 1.29 (d, J = 1.6 Hz, 6H).
720 1 H NMR (400 MHz, Methanol-d4) δ 8.86 - 8.65 (m, 2H), 8.56 (s, 1 H), 8.36 (s, 1 H),
7.91 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.1 , 9.4, 2.1 Hz, compound 1 H-NMR
1 H), 3.92 (ddd, J = 36.6, 14.5, 2.1 Hz, 1 H), 3.61 - 3.44 (m, 1 H), 3.41 (s, 3H), 3.10 (t, J = 6.6 Hz, 2H), 1.99 (dd, J = 11.1 , 5.7 Hz, 2H), 1.57 (s, 8H), 1.28 (d, J = 1 .7 Hz, 6H).
721 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.71 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.31 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.43 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 3.93 (ddd, J = 36.7, 14.5, 2.1 Hz, 1 H), 3.56 - 3.40 (m, 4H), 3.23 - 3.16 (m, 2H), 2.24 - 2.09 (m, 2H), 1.60 (s, 6H), 1.28 (d, J = 1.6 Hz, 6H).
722 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.71 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.36 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.00 - 3.80 (m, 3H), 3.72 (s, 3H), 3.68 - 3.57 (m, 2H), 3.54 - 3.37 (m, 1 H), 2.61 (t, J = 2.3 Hz, 1 H), 2.12 (s, 1 H), 2.03 (s, OH), 1 .28 (d, J = 1.6 Hz, 6H).
723 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.71 - 8.57 (m, 2H),
8.01 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.25 (s, 1 H), 4.01 - 3.77 (m, 3H), 3.69 (s, 2H), 3.64 - 3.42 (m, 1 H), 2.64 (dt, J = 14.0, 6.8 Hz, 2H), 2.16 (d, J = 12.6 Hz, 4H), 1.94 (t, J = 13.1 Hz, 2H), 1 .73 (d, J = 12.6 Hz, 2H), 1.29 (d, J = 1 .6 Hz, 6H).
724 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.04 (d, J = 5.0 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.17 - 3.68 (m, 5H), 3.49 (ddd, J = 16.0, 14.5, 9.4 Hz, 2H), 3.43 - 3.32 (m, 1 H), 2.68 (tt, J = 14.1 , 7.5 Hz, 2H), 2.33 (d, J = 10.2 Hz, 3H), 2.03 (s, 1 H), 1.86 - 1.71 (m, 2H), 1 .58 (q, J = 12.1 Hz, 2H), 1.28 (d, J = 1 .7 Hz, 6H).
725 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.71 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.75 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.59 - 4.30 (m, 2H), 4.23 (d, J = 6.9 Hz, 2H), 3.94 (ddd, J = 36.6, 14.6, 2.1 Hz, 1 H), 3.49 (ddd, J = 16.1 , 14.6, 9.4 Hz, 1 H), 2.73 (s, 3H), 2.70 (s, 1 H), 2.52 (t, J = 9.8 Hz, 2H), 2.40 - 2.21 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
726 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.53 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.83 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.43 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 3.94 (ddd, J = 36.5, 14.6, 2.2 Hz, 1 H), 3.61 - 3.42 (m, 6H), 1.96 - 1.64 (m, 4H), 1.28 (d, J = 1.7 Hz, 6H), 1 .27 (s, 6H).
727 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.52 (s, 1 H), 8.20 (d, J = 5.0 Hz, 1 H), 7.81 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 3.99 - 3.75 (m, 1 H), 3.65 - 3.36 (m, 6H), 2.29 - 2.13 (m, 2H), 1.34 (s, 6H), 1.28 (d, J = 1 .6 Hz, 6H).
728 1 H NMR (400 MHz, Methanol-d4) δ 9.00 (t, J = 5.7 Hz, OH), 8.74 (s, 2H), 8.57 (s,
1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.80 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 6.02 (tt, J = 55.0, 3.7 Hz, 1 H), 4.53 - 4.22 (m, 4H), 3.93 (ddd, J = 36.4, 14.6, 2.1 Hz, 1 H), 3.57 - 3.41 (m, 1 H), 3.41 - 3.31 (m, 3H), 2.56 (d, J = 4.2 Hz, 1 H), 2.52 - 2.41 (m, 2H), 2.27 (td, J = 12.3, 11.0, 8.0 Hz, 2H), 1.29 (d, J = 1 .6 Hz, 6H).
729 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.66 - 8.50 (m, 2H),
8.21 - 8.1 1 (m, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.80 - 7.65 (m, 2H), 7.20 (d, J = 5.1 Hz, 1 H), 6.99 (ddd, J = 7.2, 5.1 , 0.9 Hz, 1 H), 6.88 (dt, J = 8.5, 0.9 Hz, 1 H), 4.64 - 4.29 (m, 4H), 3.95 (ddd, J = 36.4, 14.5, 2.1 Hz, 1 H), 3.50 (ddd, J = 16.1 , 14.5, 9.4 Hz, 1 H), 2.90 (s, 1 H), 2.63 (ddd, J = 12.5, 7.5, 4.0 Hz, 2H), 2.39 (ddd, J = 13.0, 9.6, 6.8 Hz, 2H), 1 .29 (d, J = 1.6 Hz, 6H).
730 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.1 Hz,
1 H), 8.56 (d, J = 6.6 Hz, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.76 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.54 - 4.24 (m, 4H), 3.94 (ddd, J = 36.4, 14.6, 2.2 Hz, 1 H), 3.66 - 3.41 (m, 1 H), 2.90 - 2.75 (m, 2H), 2.72 - 2.62 (m, 1 H), 2.05 - 1.89 (m, 2H), 1 .29 (d, J = 1.6 Hz, 6H).
731 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.50 (s, 1 H), 8.26 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 3.91 (p, J = 8.3 Hz, 1 H), 3.60 (s, 3H), 3.43 - 3.34 (m, 2H), 2.42 (qd, J = 7.6, 2.8 Hz, 2H), 2.24 (t, J = 8.0 Hz, 7H), 1.96 - 1.83 (m, 6H), 1.72 (d, J = 10.3 Hz, 2H).
732 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.50 (s, 1 H), 8.26 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.28 - 4.07 (m, 1 H), 3.40 (d, J = 6.9 Hz, 2H), 2.45 (tdd, J = 10.3, 6.4, 2.7 Hz, 2H), 2.24 (dd, J = 10.2, 5.8 Hz, 7H), 1 .99 - 1 .86 (m, 6H), 1.73 (qd, J = 9.2, 2.8 Hz, 2H), 1 .51 (tt, J = 8.0, 4.7 Hz, 1 H), 0.90 - 0.76 (m, 2H), 0.73 (dt, J = 8.0, 3.0 Hz, 2H).
733 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.49 (s, 1 H), 8.26 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.18 (p, J = 7.8 Hz, 1 H), 3.72 (p, J = 6.6 Hz, 1 H), 3.61 (s, 3H), 3.47 (d, J = 7.7 Hz, 2H), 3.22 (q, J = 7.4 Hz, 1 H), 2.48 (ddd, J = 12.5, 8.2, 4.0 Hz, 1 H), 2.32 - 2.20 (m, 6H), 2.21 - 2.04 (m, 3H), 2.00 - 1 .84 (m, 6H).
734 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.74 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), compound 1 H-NMR
4.54 - 4.32 (m, 2H), 4.26 (d, J = 7.2 Hz, 2H), 3.93 (ddd, J = 36.5, 14.5, 2.1 Hz, 1 H), 3.50 (ddd, J = 16.1 , 14.5, 9.3 Hz, 1 H), 2.95 (s, 6H), 2.74 (d, J = 12.8 Hz, 1 H), 2.64 - 2.47 (m, 2H), 2.40 - 2.24 (m, 2H), 1 .29 (d, J = 1.6 Hz, 6H).
735 1 H NMR (400 MHz, Methanol-d4) δ 8.84 - 8.64 (m, 2H), 8.57 (s, 1 H), 7.97 (d, J =
5.1 Hz, 1 H), 7.76 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.60 - 4.30 (m, 2H), 4.24 (d, J = 6.9 Hz, 2H), 4.08 - 3.84 (m, 1 H), 3.49 (td, J = 15.3, 9.4 Hz, 1 H), 2.70 (s, 1 H), 2.55 (td, J = 7.3, 3.8 Hz, 3H), 2.31 (d, J = 9.9 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H), 0.68 (d, J = 6.8 Hz, 2H), 0.53 - 0.39 (m, 2H).
736 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.97 (d, J = 5.1 Hz, 1 H), 7.73 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 6.06 - 5.62 (m, 1 H), 4.65 - 4.30 (m, 2H), 4.27 (d, J = 6.9 Hz, 2H), 4.11 - 3.70 (m, 1 H), 3.49 (td, J = 15.2, 4.0 Hz, 2H), 2.73 (s, 1 H), 2.53 (dd, J = 12.0, 6.8 Hz, 2H), 2.32 (q, J = 10.8, 9.9 Hz, 2H), 1.29 (d, J = 1 .6 Hz, 6H).
737 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.71 (s, 1 H), 8.57 (s,
1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.72 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.56 - 4.33 (m, 2H), 4.30 (d, J = 7.0 Hz, 2H), 4.1 1 - 3.84 (m, 1 H), 3.85 - 3.39 (m, 5H), 2.76 (s, 1 H), 2.54 (td, J = 8.7, 7.9, 4.2 Hz, 2H), 2.47 - 2.22 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
738 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (dd, J = 18.9, 2.2 Hz, 2H), 8.58 (s, 1 H),
7.98 (d, J = 5.0 Hz, 1 H), 7.72 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.52 - 4.41 (m, 1 H), 4.39 - 4.20 (m, 5H), 3.94 (ddd, J
= 36.5, 14.6, 2.1 Hz, 1 H), 3.63 - 3.39 (m, 1 H), 2.75 (s, 1 H), 2.53 (ddd, J = 12.5, 7.7, 3.9 Hz, 2H), 2.33 (ddd, J = 12.6, 9.2, 6.7 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
739 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.53 (s, 1 H), 8.28 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 3.73 (d, J = 23.9 Hz, 2H), 2.45 - 2.10 (m, 9H), 1 .95 - 1 .73 (m, 6H), 1.63 (p, J = 9.2, 8.7 Hz, 1 H), 1.19 (s, 1 H).
740 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.28 (s, 1 H), 7.93 (d, J = 5.0 Hz, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 3.57 (d, J = 20.6 Hz, 2H), 2.24 (dd, J = 9.5, 6.5 Hz, 6H), 1 .93 - 1 .83 (m, 6H), 1.39 (d, J = 21.1 Hz, 6H).
741 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.51 (s, 1 H), 8.27 (s,
1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 3.68 (s, 3H), 3.52 (td, J = 14.1 , 13.0, 7.8 Hz, 2H), 3.45 - 3.32 (m, 2H), 3.16 (dd, J = 10.9, 6.9 Hz, 1 H), 2.54 (q, J = 7.6 Hz, 1 H), 2.24 (dd, J = 10.3, 5.7 Hz, 6H), 2.07 (dt, J = 12.8, 6.3 Hz, 1 H), 1 .98 - 1.81 (m, 6H), 1.74 (dq, J = 14.1 , 7.7 Hz, 1 H).
742 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.52 (s, 1 H), 8.28 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 3.68 (s, 3H), 3.62 - 3.46 (m, 2H), 3.37 (dd, J = 18.5, 8.1 Hz, 2H), 3.16 (dd, J = 10.9, 6.9 Hz, 1 H), 2.54 (q, J = 7.7 Hz, 1 H), 2.32 - 2.18 (m, 6H), 2.07 (dt, J = 12.8, 6.5 Hz, 1 H), 1.97 - 1.84 (m, 6H), 1.74 (dq, J = 15.0, 7.8 Hz, 1 H).
743 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 8.31 (s, 1 H), 7.92 (d, J = 5.0 Hz, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.78 (s, 1 H), 4.44 - 4.10 (m, 2H), 3.78 - 3.55 (m, 2H), 2.71 (s, 3H), 2.24 (dd, J = 10.1 , 6.0 Hz, 6H), 1.90 (dd, J = 10.3, 5.7 Hz, 6H).
744 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.51 (s, 1 H), 8.28 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.09 (t, J = 8.5 Hz, 2H), 3.75 (dd,
J = 8.8, 5.3 Hz, 2H), 3.64 (s, 3H), 3.59 (dd, J = 6.9, 4.4 Hz, 2H), 2.95 - 2.80 (m, 1 H), 2.24 (dd, J = 10.4, 5.6 Hz, 6H), 1.90 (dd, J = 10.3, 5.7 Hz, 6H).
745 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 8.28 (s, 1 H), 7.91 (d, J = 5.0 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 3.71 (t, J = 5.6 Hz, 2H), 3.57 - 3.42 (m, 2H), 2.24 (dd, J = 10.3, 5.8 Hz, 6H), 2.00 - 1 .82 (m, 6H).
746 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.1 Hz,
1 H), 8.50 (s, 1 H), 8.29 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 3.63 (s, 3H), 3.45 (dd, J = 6.6, 5.0 Hz, 2H), 3.33 (d, J = 6.0 Hz, 2H), 2.28 - 2.19 (m, 6H), 1.95 - 1.86 (m, 6H).
747 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.19 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.61 - 4.28 (m, 1 H), 4.16 (qd, J = 1 1.6, 6.5 Hz, 2H), 3.91 (ddd, J = 36.4, 14.5, 2.2 Hz, 1 H), 3.47 (ddd, J = 16.1 , 14.5, 9.3 Hz, 1 H), 2.86 (dt, J = 7.5, 3.8 Hz, 1 H), 2.66 (s, 3H), 1.51 (d, J = 8.4 Hz, 1 H), 1.28 (d, J = 1 .7 Hz, 6H), 1.21 - 1.03 (m, 2H).
748 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.63 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 7.98 - 7.81 (m, 2H), 7.21 (d, J = 5.0 Hz, 1 H), 5.03 (s, 1 H), 4.42 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1 H), 4.11 (d, J = 10.5 Hz, 1 H), 3.93 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.63 - 3.40 (m, 1 H), 2.73 (s, 3H), 2.29 (d, J = 13.6 Hz, 1 H), 2.09 (d, J = 12.4 Hz, 1 H), 1 .95 - 1.53 (m, 6H), 1 .28 (d, J = 1.6 Hz, 6H).
749 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz, compound 1H-NMR
1 H), 8.57 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.69 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.56 - 4.25 (m, 2H), 3.93 (ddd, J =
36.5, 14.6, 2.2 Hz, 1H), 3.63-3.36 (m, 1H), 2.86-2.71 (m, 4H), 2.62 (t, J = 12.2 Hz, 2H), 2.43 - 2.25 (m, 2H), 1.29 (d, J = 1.6 Hz, 6H).
750 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.57 - 4.29 (m, 2H), 4.14 (p, J = 6.6 Hz, 1 H), 3.92 (ddd, J = 36.4, 14.6, 2.2 Hz, 1 H), 3.65 (s, 3H), 3.49 (ddd, J = 16.0, 14.5, 9.4 Hz, 1H), 2.54-2.32 (m, 1H), 2.21 (ddq, J = 16.2, 6.7, 3.4 Hz, 2H), 2.13 - 1.90 (m, 1 H), 1.86 - 1.57 (m, 2H), 1.28 (d, J = 1.6 Hz, 6H).
751 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (s, 1 H), 8.63 (s,
1 H), 8.04 (d, J = 5.1 Hz, 1 H), 7.90 (d, J = 6.6 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.60 (d, J = 9.5 Hz, 1H), 4.42 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 3.88 (dt, J = 14.5, 3.2 Hz, 2H), 3.72 (d, J = 5.2 Hz, 3H), 3.60 (s, 2H), 3.56 - 3.42 (m, 2H), 2.46 (d, J = 16.4 Hz, 1H), 2.28 -2.08 (m, 1H), 1.28 (d, J = 1.7 Hz, 6H).
752 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.67 (s, 1 H), 8.63 (s,
1 H), 8.04 (d, J = 5.0 Hz, 1 H), 7.90 (d, J = 6.9 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.59 (s, 1 H), 4.42 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 3.93 - 3.83 (m, 1 H), 3.72 (d, J = 5.3 Hz, 3H), 3.60 (s, 2H), 3.56 - 3.41 (m, 2H), 2.56 - 2.31 (m, 1 H), 2.29 - 2.08 (m, 1H), 1.28 (d, J = 1.6 Hz, 6H).
753 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.29 (s, 1 H), 7.92 (d, J = 5.0 Hz, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 3.39 (s, 2H), 2.23 (dd, J = 10.4, 5.6 Hz, 6H), 1.90 (dd, J = 10.3, 5.8 Hz, 6H), 1.24 (s, 6H).
754 1 H NMR (400 MHz, Methanol-d4) δ 8.66 (d, J = 2.2 Hz, 1 H), 8.60 (d, J = 2.2 Hz,
1H), 8.53 (s, 1H), 7.90 (d, J = 5.0 Hz, 1H), 7.75 (s, 1H), 7.14 (d, J =5.0 Hz, 1H), 4.42 (ddd, J =48.7, 9.3, 2.1 Hz, 1H), 4.15 (p, J =7.6 Hz, 1H), 4.10-3.81 (m, 2H), 3.61 (s, 3H), 3.48 (ddd, J = 16.2, 14.5, 9.3 Hz, 1H), 2.77 (ddd, J = 11.6, 6.9, 4.3 Hz, 1H), 2.58 (tdd, J = 12.0, 7.4, 4.8 Hz, 2H), 2.34 (ddd, J = 12.2, 7.4, 5.1 Hz, 1H), 2.19-1.96 (m, 4H), 1.29 (d, J = 1.6 Hz, 6H).
755 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.52 (d, J = 4.8 Hz, 3H), 8.29 (s,
2H), 7.95 - 7.81 (m, 2H), 7.76 - 7.64 (m, 2H), 7.29 (t, J = 5.6 Hz, 1 H), 7.03 (d, J = 5.0 Hz, 1H), 4.49 (ddd, J = 49.1, 9.3, 2.1 Hz, 1H), 4.14-3.82 (m, 1H), 3.52 (td, J = 15.3, 9.2 Hz, 1H), 1.33 (d, J = 1.6 Hz, 6H).
756 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 7.98 (d, J = 5.0 Hz, 1 H), 7.69 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.35 (dd, J = 9.3, 2.1 Hz, 1 H), 4.26 (q, J = 7.7 Hz, 1 H), 4.06 - 3.83 (m, 2H), 3.61 (s, 3H), 3.58-3.37 (m, 1H), 2.81-2.72 (m, J = 11.4 Hz, 1H), 2.60 (ddt, J = 17.5, 11.8, 6.7 Hz, 2H), 2.35 (dt, J = 12.2, 6.1 Hz, 1 H), 2.24 - 1.96 (m, 4H), 1.28 (d, J = 1.6 Hz, 6H).
757 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.69 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.42 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 4.27 (p, J =7.6 Hz, 1H), 4.12-3.83 (m, 2H), 3.61 (s, 3H), 3.57-3.36 (m, 2H), 2.79 (t, J = 5.9 Hz, 1H), 2.60 (ddt, J = 17.2, 11.7, 6.5 Hz, 2H), 2.42 - 2.26 (m, 1 H), 2.24 - 2.06 (m, 3H), 2.02 (s, 1 H), 1.28 (d, J = 1.7 Hz, 6H).
758 1H NMR (400 MHz, Methanol-d4) δ 8.89 - 8.70 (m, 1H), 8.73-8.54 (m, 2H), 8.10- 7.91 (m, 2H), 7.21 (t, J = 5.2 Hz, 1 H), 4.64 - 4.29 (m, 2H), 4.18 - 3.84 (m, 2H), 3.68 (d, J =44.8 Hz, 3H), 3.55-3.40 (m, 3H), 3.08-2.77 (m, 1H), 2.44 (dd, J = 13.8, 8.4 Hz, 2H), 1.40-1.21 (m, 6H).
759 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.74 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.58 - 4.32 (m, 2H), 4.05 - 3.83 (m, 1 H), 3.62 (s, 3H), 3.54 - 3.39 (m, 1 H), 3.27 (s, 2H), 2.61 (m, J = 13.4, 8.1 Hz, 2H), 2.29 (dd, J = 12.9, 6.8 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
760 1 H NMR (400 MHz, Methanol-d4) δ 8.82 (s, 1 H), 8.75 (d, J = 2.1 Hz, 1 H), 8.57 (s,
1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.95 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.57 - 4.27 (m, 1H), 4.12-3.82 (m, 2H), 3.72 (s, 3H), 3.48 (td, J = 15.4, 9.3 Hz, 1H), 3.37 (s, 2H), 2.99-2.82 (m, 2H), 2.11 (t, J = 10.0 Hz, 2H), 1.29 (d, J = 1.7 Hz, 6H).
761 1 H NMR (400 MHz, Methanol-d4) δ 8.90 (s, 1 H), 8.79 - 8.67 (m, 4H), 8.56 (d, J =
2.2 Hz, 1H), 8.31 -8.10 (m, 4H), 7.90 (d, J =5.0 Hz, 1H), 7.17 (d, J =5.0 Hz, 1H), 4.47 (dd, J =48.8, 9.1 Hz, 1H), 4.18-3.90 (m, 1H), 3.63-3.47 (m, 1H), 1.30 (d, J = 1.7 Hz, 6H).
762 1H NMR (400 MHz, Methanol-d4) δ 9.18 (s, 1H), 8.73 (s, 1H), 8.67 (d, J =2.2 Hz,
1 H), 8.58 (d, J = 2.2 Hz, 1 H), 8.37 (s, 1 H), 8.23 (s, 1 H), 8.03 (d, J = 8.8 Hz, 2H), 7.82 (d, J = 5.0 Hz, 1H), 7.67 (d, J =8.8 Hz, 2H), 7.14 (d, J =5.1 Hz, 1H), 4.57- 4.25 (m, 1H), 3.99 (dd, J =35.7, 14.4 Hz, 1H), 3.68-3.41 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
763 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (t, J = 1.6 Hz, 1 H), 8.69 (t, J = 2.3 Hz, compound 1H-NMR
1 H), 8.59 (d, J = 2.0 Hz, 1 H), 8.00 (t, J = 4.9 Hz, 1 H), 7.75 (d, J = 11.7 Hz, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.62 - 4.29 (m, 2H), 4.02 - 3.81 (m, 1 H), 3.73 (d, J = 45.0 Hz, 2H), 3.60 - 3.38 (m, 1 H), 3.21 - 2.94 (m, 2H), 2.71 - 2.46 (m, 2H), 1.29 (t, J = 1.8 Hz, 6H).
764 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (s, 1 H), 8.62 (s, 1 H), 8.54 (s, 1 H), 8.03 (s,
1H), 7.90 (d, J =5.0 Hz, 1H), 7.12 (d, J =4.9 Hz, 1H), 4.55-4.31 (m, 1H), 4.09- 3.81 (m, 2H), 3.75 (s, 3H), 3.53 (dt, J = 24.8, 7.7 Hz, 3H), 2.97 (d, J = 8.0 Hz, 2H), 2.51 -2.16(m, 2H), 1.29 (s, 6H).
765 1 H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 2.2 Hz, 1 H), 8.63 (d, J = 2.2 Hz,
1H), 8.58 (s, 1H), 7.95 (d, J = 5.0 Hz, 1H), 7.73 (s, 1H), 7.17 (d, J =5.0 Hz, 1H), 4.56 - 4.33 (m, 2H), 3.94 (ddd, J =
36.2, 14.6, 2.2 Hz, 1H), 3.62 (s, 3H), 3.53-3.40 (m, 3H), 2.89 (ddd, J = 19.0, 14.3, 8.4 Hz, 2H), 2.42 (ddd, J = 19.8, 14.1, 5.7 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
766 1 H NMR (400 MHz, Methanol-d4) δ 9.40 (s, 1 H), 8.82 - 8.51 (m, 4H), 8.34 - 8.07
(m, 4H), 7.85 (d, J =5.1 Hz, 1H), 7.15 (d, J = 5.1 Hz, 1H), 4.48 (dd, J =49.1, 9.3 Hz, 1H), 4.00 (dd, J = 36.1, 14.7 Hz, 1H), 3.66-3.45 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
767 1 H NMR (400 MHz, Methanol-d4) δ 9.49 (t, J = 1.5 Hz, 1 H), 8.78 (s, 1 H), 8.71 (s,
1H), 8.61 (d, J =2.2 Hz, 1H), 8.42 (s, 1H), 8.15 (t, J = 1.8 Hz, 1H), 8.02-7.90 (m, 2H), 7.86 (d, J =5.1 Hz, 1H), 7.84-7.73 (m, 3H), 7.17 (d, J =5.1 Hz, 1H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.98 (ddd, J = 36.4, 14.5, 2.1 Hz, 1 H), 3.76 - 3.41 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
768 1 H NMR (400 MHz, Methanol-d4) δ 9.82 (d, J = 1.8 Hz, 1 H), 8.82 (s, 1 H), 8.77 (dd,
J = 2.6, 0.7 Hz, 1 H), 8.72 (d, J = 2.2 Hz, 1 H), 8.61 (d, J = 2.2 Hz, 1 H), 8.45 (t, J = 1.8 Hz, 1 H), 8.36 - 8.27 (m, 2H), 8.15 (dd, J = 8.7, 0.7 Hz, 1 H), 7.90 (d, J = 5.1 Hz, 1H), 7.82 (t, J = 1.8 Hz, 1H), 7.17 (d, J =5.1 Hz, 1H), 4.48 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 3.99 (ddd, J =36.4, 14.6, 2.1 Hz, 1H), 3.56 (ddd, J = 16.1, 14.5, 9.3 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
769 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.67 (m, 2H), 8.60 (d, J = 2.2 Hz, 1 H),
8.37 - 8.23 (m, 2H), 7.96 (d, J = 8.8 Hz, 2H), 7.86 - 7.75 (m, 2H), 7.66 - 7.53 (m, 2H), 7.15 (d, J =5.1 Hz, 1H), 6.59 (dd, J = 2.5, 1.8 Hz, 1H), 4.47 (ddd, J =49.0, 9.3, 2.1 Hz, 1H), 4.00 (dd, J =36.6, 14.8 Hz, 1H), 3.74-3.42 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
770 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (s, 1 H), 8.69 (d, J = 2.2 Hz, 1 H), 8.65 (dd,
J = 2.6, 0.7 Hz, 1 H), 8.60 - 8.51 (m, 2H), 8.21 - 8.01 (m, 3H), 7.89 - 7.73 (m, 2H), 7.14 (d, J = 5.1 Hz, 1H), 6.59 (dd, J =2.6, 1.7 Hz, 1H), 4.48 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 4.00 (ddd, J =36.3, 14.6, 2.1 Hz, 1H), 3.72-3.42 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
771 1 H NMR (400 MHz, Methanol-d4) δ 9.48 (s, 1 H), 8.75 (s, 1 H), 8.66 (d, J = 2.3 Hz,
1H), 8.59 (d, J =2.1 Hz, 1H), 8.52 (s, 1H), 8.30-8.13 (m, 2H), 7.84 (d, J =5.0 Hz, 1H), 7.66 (d, J =8.6 Hz, 2H), 7.14 (d, J =5.0 Hz, 1H), 4.61 - 4.36 (m, 1H), 4.18- 3.84 (m, 1 H), 3.64 - 3.40 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
772 1 H NMR (400 MHz, Methanol-d4) δ 9.08 (s, 2H), 8.74 (s, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.62 (d, J = 2.2 Hz, 1 H), 8.38 (s, 1 H), 7.98 - 7.79 (m, 3H), 7.77 - 7.62 (m, 2H), 7.15 (d, J = 5.0 Hz, 1H), 4.47 (ddd, J =49.1, 9.4, 2.2 Hz, 1H), 4.11 -3.88 (m, 1H), 3.71 - 3.44 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
773 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 1.7 Hz, 1 H), 8.73 (s, 1 H), 8.69 (d,
J =2.2 Hz, 1H), 8.58 (d, J =2.1 Hz, 1H), 8.34 (s, 1H), 8.17-8.03 (m, 2H), 7.81 (d, J =5.1 Hz, 1H), 7.67-7.57 (m, 2H), 7.15 (d, J = 5.0 Hz, 1H), 7.01 (d, J = 1.7 Hz, 1 H), 4.47 (ddd, J = 48.9, 9.3, 2.1 Hz, 1 H), 4.00 (ddd, J = 36.3, 14.6, 2.1 Hz, 1 H), 3.70 - 3.46 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
774 1 H NMR (400 MHz, Methanol-d4) δ 8.80 - 8.67 (m, 2H), 8.56 (d, J = 2.2 Hz, 1 H),
8.34-8.19 (m, 3H), 7.98 (s, 2H), 7.80 (d, J =5.1 Hz, 1H), 7.71 - 7.58 (m, 2H), 7.15 (d, J = 5.1 Hz, 1H), 4.48 (ddd, J
= 49.0, 9.3, 2.1 Hz, 1H), 4.00 (ddd, J =36.4, 14.6, 2.1 Hz, 1H), 3.65-3.51 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
775 1 H NMR (400 MHz, Methanol-d4) δ 8.86 - 8.80 (m, 2H), 8.70 (d, J = 2.2 Hz, 1 H),
8.60 (d, J = 2.2 Hz, 1H), 8.27 (d, J =9.3 Hz, 2H), 8.10 (dd, J =8.5, 2.6 Hz, 1H), 7.86 (d, J = 5.1 Hz, 1H), 7.16 (d, J
= 5.1 Hz, 1 H), 7.12 (d, J = 1.7 Hz, 1 H), 4.48 (ddd, J = 49.0, 9.3, 2.2 Hz, 1 H), 4.00 (ddd, J =36.3, 14.6, 2.1 Hz, 1H), 3.70-3.40 (m, 1H), 1.30 (d, J = 1.6 Hz, 6H).
776 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.56 (d, J = 6.9 Hz, 2H), 8.06 - 7.92 (m, 2H), 7.67 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1H), 4.48 (d, J =7.6 Hz, 2H), 4.44-4.30 (m, 1H), 3.93 (ddd, J =36.4, 14.6, 2.1 Hz, 1 H), 3.72 (hept, J = 6.5 Hz, 1 H), 3.56 - 3.46 (m, 1 H), 3.22 (q, J = 7.4 Hz, 1 H), 2.57 (ddd, J = 12.7, 7.6, 4.2 Hz, 2H), 2.34 (ddd, J = 13.1, 9.3, 6.5 Hz, 2H), 1.28 (d, J = 1.7 Hz, 6H).
777 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.61 - 8.51 (m, 2H), 8.02 (d, J = 5.1 Hz, 1 H), 7.91 (s, 1 H), 7.21 (d, J = 5.0 Hz, compound 1H-NMR
1 H), 6.47 (d, J = 1.7 Hz, 1 H), 4.42 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 4.07 - 3.81 (m, 2H), 3.61 -3.40 (m, 1H), 3.00-2.82 (m, 1H), 2.38-2.24 (m, 2H), 2.19 (d, J = 13.5 Hz, 2H), 1.81 (q, J = 12.6 Hz, 2H), 1.64 (q, J = 11.7, 11.1 Hz, 2H), 1.29 (d, J = 1.7 Hz, 6H).
778 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.70 (dd, J = 7.7, 2.4 Hz, 2H),
8.64 (d, J = 2.1 Hz, 1H), 8.32 (d, J =8.7 Hz, 1H), 8.25 (s, 1H), 8.16 (dd, J =8.8, 2.6 Hz, 1H), 8.10 (s, 2H), 7.86 (d, J =5.1 Hz, 1H), 7.15 (d, J =5.1 Hz, 1H), 4.48 (ddd, J =49.0, 9.4, 2.1 Hz, 1H), 3.99 (ddd, J = 36.5, 14.6, 2.1 Hz, 1H), 3.56 (ddd, J = 16.2, 14.5, 9.4 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
779 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.2 Hz, 1 H), 8.66 (d, J = 2.2 Hz,
1H), 8.58 (s, 1H), 8.53 (s, 1H), 8.09-7.87 (m, 3H), 7.19 (d, J = 5.1 Hz, 1H), 4.51 - 4.30 (m, 2H), 3.92 (ddd, J = 36.2, 14.8, 2.3 Hz, 2H), 3.72 (hept, J = 6.6 Hz, 2H), 3.57-3.41 (m, 1H), 3.22 (q, J = 7.4 Hz, 2H), 2.16 (dt, J = 13.3, 10.7 Hz, 2H), 1.70 (q, J = 11.8 Hz, 2H), 1.29 (d, J = 1.7 Hz, 6H).
780 1 H NMR (400 MHz, Methanol-d4) δ 8.86 - 8.64 (m, 2H), 8.59 (s, 1 H), 8.28 (s, 1 H),
7.95 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.40 (ddd, J = 49.1 , 9.4, 2.1 Hz, 1H), 4.12 (s, 2H), 3.90 (ddd, J = 36.4, 14.5, 2.0 Hz, 1H), 3.72 (p, J = 6.6 Hz, 2H), 3.49 (td, J = 15.2, 9.3 Hz, 2H), 3.22 (q, J = 7.4 Hz, 2H), 2.33 (t, J = 7.8 Hz, 6H), 2.24 - 2.11 (m, 6H), 1.28 (d, J = 1.6 Hz, 6H).
781 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (d, J = 2.2 Hz, 1 H), 8.64 (d, J = 2.2 Hz,
1H), 8.56 (s, 1H), 7.98 (d, J = 5.0 Hz, 1H), 7.88 (s, 1H), 7.19 (d, J =5.1 Hz, 1H), 4.50 (s, 2H), 4.49-4.30 (m, 3H), 4.01 - 3.74 (m, 2H), 3.48 (ddd, J = 16.1, 14.5, 9.4 Hz, 1H), 2.16 (d, J = 13.5 Hz, 2H), 2.09- 1.98 (m, 1H), 1.88 - 1.72 (m, 2H), 1.64- 1.43 (m, 2H), 1.28 (d, J = 1.7 Hz, 6H).
782 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (s, 1 H), 8.57 - 8.38 (m, 4H), 8.27 (d, J =
2.2 Hz, 1H), 8.18 (d, J =2.3 Hz, 1H), 7.77 (d, J =4.9 Hz, 1H), 7.01 (d, J =4.9 Hz, 1 H), 4.48 (ddd, J = 49.0, 9.1 , 2.2 Hz, 1 H), 3.98 (s, 4H), 3.64 - 3.41 (m, 1 H), 1.31 (d, J = 1.6 Hz, 6H).
783 1 H NMR (400 MHz, Methanol-d4) δ 8.99 (s, 1 H), 8.75 (d, J = 2.2 Hz, 1 H), 8.66 (d,
J = 2.1 Hz, 1 H), 8.60 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.70 (d, J = 1.7 Hz, 1 H), 7.64 (s, 1 H), 7.60 (t, J = 1.7 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.66 - 4.31 (m, 3H), 3.92 (dd, J =36.3, 14.6 Hz, 1H), 3.72 (dt, J = 13.2, 6.4 Hz, 1H), 3.50 (td, J = 15.4, 9.1 Hz, 1 H), 3.09 - 2.94 (m, 1 H), 2.54 (q, J = 7.1 Hz, 2H), 2.45 - 2.34 (m, 2H), 1.28 (d, J = 1.6 Hz, 5H).
784 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 1 H), 8.72 - 8.61 (m, 2H), 8.56 (s, 2H),
8.29 (s, 1H), 8.02 (s, 1H), 7.84 (d, J =5.1 Hz, 1H), 7.15 (d, J =5.1 Hz, 1H), 4.62 (s, 2H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 3.99 (ddd, J =36.4, 14.6, 2.1 Hz, 1H), 3.55 (dd, J = 15.5, 9.3 Hz, 1H), 3.50 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
785 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.29 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 5.48 (s, 2H), 4.26 (s, 2H), 3.71 (dt, J = 13.7, 4.7 Hz, 4H), 3.59 (dt, J = 16.1, 4.6 Hz, 4H), 2.30-2.19 (m, 6H), 1.90 (dd, J =9.3, 6.0 Hz, 6H).
786 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.31 (s, 1 H), 7.94 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.03 (s, 2H), 3.48 (ddd, J = 5.8, 5.1 , 1.2 Hz, 2H), 3.42 (td, J = 5.3, 1.2 Hz, 2H), 3.36 (s, 3H), 2.29-2.19 (m, 6H), 1.91 (dt, J = 11.5, 4.8 Hz, 6H).
787 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.71 (dd, J = 2.2, 0.4
Hz, 1 H), 8.58 (s, 1 H), 8.30 (s, 1 H), 7.93 (dd, J = 5.0, 0.5 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1H), 5.55-5.29 (m, 2H), 4.62 (dddd, J =20.3, 10.6, 6.0, 1.7 Hz, 1H), 4.47- 4.28 (m, 2H), 4.10 (dd, J =24.5, 11.7 Hz, 1H), 4.02 (s, 2H), 2.24 (dd, J = 10.0, 5.7 Hz, 6H), 1.90 (dd, J = 10.2, 5.8 Hz, 6H).
788 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.71 (m, 2H), 8.56 (s, 1 H), 7.99 (d, J =
5.1 Hz, 1 H), 7.78 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.52 - 4.31 (m, 2H), 3.94 (ddd, J = 36.3, 14.5, 2.2 Hz, 1H), 3.56-3.43 (m, 1H), 3.36 (d, J =7.4 Hz, 2H), 2.74 (s, 3H), 2.59-2.40 (m, 3H), 2.25 (ddd, J = 13.0, 10.2, 7.9 Hz, 2H), 1.29 (d, J = 1.7 Hz, 6H).
789 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.30 (s, 1 H), 7.94 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.32 (s, 2H), 3.37 (d, J =21.1 Hz,
4H), 2.96 (s, 3H), 2.24 (dd, J = 10.0, 6.0 Hz, 6H), 1.95- 1.85 (m, 6H).
790 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (dd, J = 2.2, 0.4
Hz, 1 H), 8.59 (s, 1 H), 8.29 (s, 1 H), 7.93 (dd, J = 5.0, 0.5 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.16 (s, 2H), 3.56 (t, J = 6.8 Hz, 2H), 3.48 (t, J = 6.9 Hz, 2H), 2.29 - 2.20 (m, 6H), 2.12 - 1.99 (m, 2H), 1.97 - 1.85 (m, 8H).
791 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.29 (s, 1 H), 7.94 - 7.89 (m, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.48 (ddd, J =9.4, 6.4, 1.4 Hz, 1H), 4.32 (tt, J =6.3, 3.9 Hz, 1H), 4.22 (dd, J = 10.6, 6.5 Hz, 1H), 4.14 (dd, J = 9.5, 4.1 Hz, 1H), 4.00 (d, J = 1.2 Hz, 2H), 3.92-3.83 (m, 1H), 3.33 (s, 3H), 2.24 (dd, J = 10.2, 5.7 Hz, 6H), 1.90 (dd, J compound 1 H-NMR
= 10.3, 5.8 Hz, 6H).
792 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.28 (s, 1 H), 7.93 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.25 (s, 2H), 3.63 - 3.55 (m, 2H), 3.51 (t, J = 5.3 Hz, 2H), 2.24 (dd, J = 10.2, 5.8 Hz, 6H), 1 .96 - 1.82 (m, 6H), 1.70 (dt, J = 17.5, 5.2 Hz, 4H), 1.63 - 1 .54 (m, 2H).
793 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.70 (m, 2H), 8.59 (s, 1 H), 7.99 (d, J =
5.1 Hz, 1 H), 7.84 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.53 - 4.33 (m, 2H), 4.23 (s, 2H), 3.92 (ddd, J = 36.4, 14.5, 2.1 Hz, 1 H), 3.57 - 3.46 (m, 1 H), 3.44 (d, J = 7.8 Hz, 2H), 3.27 - 3.02 (m, 6H), 2.92 (s, 3H), 2.57 (td, J = 8.3, 3.9 Hz, 1 H), 2.47 (ddt, J = 1 1.3, 7.6, 3.5 Hz, 2H), 2.25 (dtd, J = 12.7, 7.1 , 2.3 Hz, 2H), 1 .29 (d, J = 1.6 Hz, 6H).
794 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (q, J = 2.2 Hz, 2H), 8.59 (s, 1 H), 7.99 (d,
J = 5.1 Hz, 1 H), 7.79 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.52 - 4.41 (m, 2H), 4.36 (dd, J = 9.3, 2.1 Hz, 1 H), 3.92 (ddd, J = 36.4, 14.6, 2.1 Hz, 1 H), 3.64 - 3.41 (m, 5H), 3.02 (td, J = 12.9, 3.0 Hz, 2H), 2.86 (s, 3H), 2.65 - 2.38 (m, 4H), 2.28 (td, J = 12.6, 11.2, 8.0 Hz, 2H), 2.14 - 2.04 (m, 2H), 2.04 - 1.86 (m, 1 H), 1.29 (d, J = 1 .6 Hz, 6H).
795 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.65 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 7.98 (d, J = 5.1 Hz, 1 H), 7.61 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.55 - 4.44 (m, 2H), 4.37 (dd, J = 9.3, 2.1 Hz, 1 H), 3.92 (ddd, J = 36.4, 14.6, 2.1 Hz, 1 H), 3.52 (ddd, J = 16.1 , 14.5, 9.3 Hz, 1 H), 3.43 (d, J = 8.0 Hz, 2H), 3.01 (s, 7H), 2.71 (tt, J = 8.9, 4.7 Hz, 1 H), 2.48 (ddd, J = 12.9, 7.6, 4.8 Hz, 2H), 2.36 (ddd, J = 13.0, 9.1 , 6.1 Hz, 2H), 1.29 (d, J = 1.7 Hz, 6H).
796 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.29 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.75 (dd, J = 7.6, 5.6 Hz, 2H), 4.30 (s, 2H), 4.09 (p, J = 6.3 Hz, 1 H), 3.82 (s, 4H), 2.96 (d, J = 24.7 Hz, 4H), 2.24 (t, J = 8.0 Hz, 6H), 1.90 (t, J = 7.9 Hz, 6H).
797 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.58 (s, 1 H), 8.29 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.39 (ddd, J = 35.9, 18.9, 10.1 Hz,
2H), 4.22 - 4.03 (m, 2H), 4.01 (d, J = 1.8 Hz, 2H), 2.30 - 2.17 (m, 6H), 1 .96 - 1 .83 (m, 6H), 1.66 (d, J = 21.5 Hz, 3H).
798 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.59 (d, J = 0.8 Hz, 1 H), 8.29 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.20 (s, 1 H), 4.14 (s, 1 H), 4.00 (t, J = 12.6 Hz, 1 H), 3.90 - 3.67 (m, 3H), 2.54 (tt, J = 14.0, 7.4 Hz, 1 H), 2.43 (tt, J = 14.1 , 7.6 Hz, 1 H), 2.29 - 2.18 (m, 6H), 1 .94 - 1.85 (m, 6H).
799 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.62 (d, J = 1 .7 Hz, 1 H), 8.32 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 4.76 - 4.62 (m, 4H), 4.19 (d, J = 14.7 Hz, 2H), 3.87 (s, 1 H), 3.75 (s, 1 H), 3.63 (q, J = 7.2 Hz, 1 H), 3.57 - 3.46 (m, 1 H), 2.38 (t, J = 7.0 Hz, 1 H), 2.32 - 2.19 (m, 7H), 1.93 (t, J = 8.1 Hz, 6H).
800 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.1 Hz, 1 H), 8.72 (d, J = 2.1 Hz,
1 H), 8.54 (s, 1 H), 8.25 (s, 1 H), 7.99 (d, J = 5.0 Hz, 1 H), 7.25 (d, J = 5.0 Hz, 1 H), 3.15 (s, 11 H), 2.39 - 2.29 (m, 6H),
2.02 - 1.91 (m, 6H).
801 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.1 Hz, 1 H), 8.72 (d, J = 2.1 Hz,
1 H), 8.51 (s, 1 H), 8.30 (s, 1 H), 7.96 (d, J = 5.0 Hz, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 4.18 (q, J = 7.1 Hz, 2H), 3.65 (t, J = 6.7 Hz, 2H), 2.68 (t, J = 6.7 Hz, 2H), 2.27 (dd, J = 10.3, 5.7 Hz, 6H), 2.01 - 1.86 (m, 6H), 1 .29 (t, J = 7.1 Hz, 3H).
802 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1 H), 8.71 (d, J = 2.1 Hz,
1 H), 8.59 (s, 1 H), 8.28 (s, 1 H), 7.97 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 4.55 - 4.32 (m, 1 H), 3.93 (dd, J = 36.4, 14.6 Hz, 1 H), 3.51 (td, J = 15.5, 9.4 Hz, 2H), 2.97 (s, 3H), 2.21 (d, J = 7.3 Hz, 15H), 1 .31 (s, 6H). Some protons from the piperazine are under solvent.
803 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1 H), 8.72 (d, J = 2.1 Hz,
1 H), 8.50 (s, 1 H), 8.29 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 3.64 (t, J = 6.6 Hz, 2H), 2.76 (s, 3H), 2.53 (t, J = 6.7 Hz, 2H), 2.27 (dd, J = 10.4, 5.7 Hz, 6H), 1.93 (dd, J = 10.3, 5.7 Hz, 6H).
804 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.1 Hz, 1 H), 8.72 (d, J = 2.1 Hz,
1 H), 8.51 (s, 1 H), 8.29 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 3.65 (t, J = 6.6 Hz, 2H), 3.11 (s, 3H), 2.98 (s, 3H), 2.75 (t, J = 6.7 Hz, 2H), 2.27 (dd, J = 10.3, 5.6 Hz, 6H), 1.93 (dd, J = 10.3, 5.7 Hz, 6H).
805 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.1 Hz, 1 H), 8.72 (d, J = 2.1 Hz,
1 H), 8.51 (s, 1 H), 8.30 (s, 1 H), 7.95 (d, J = 5.0 Hz, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 4.63 (t, J = 12.0 Hz, 2H), 4.35 (t,
J = 12.2 Hz, 2H), 3.65 (t, J = 6.6 Hz, 2H), 2.60 (t, J = 6.6 Hz, 2H), 2.27 (dd, J = 10.4, 5.6 Hz, 6H), 1.93 (dd, J = 10.1 , 5.6 Hz, 6H). compound 1 H-NMR
806 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.1 Hz, 1 H), 8.72 (d, J = 2.1 Hz,
1 H), 8.54 (s, 1 H), 8.30 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 3.67 (t, J = 6.6 Hz, 2H), 2.97 (s, 3H), 2.82 (t, J = 6.7 Hz, 2H), 2.32 - 2.22 (m, 6H), 1 .93 (t, J = 8.0 Hz, 6H). Piperazine peaks obscured by solvent peaks
807 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.1 Hz, 1 H), 8.69 (d, J = 2.1 Hz,
1 H), 8.61 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.87 (s, 1 H), 7.23 (d, J = 5.0 Hz, 1 H), 4.75 (t, J = 12.0 Hz, 2H), 4.44 (t,
J = 12.2 Hz, 2H), 4.19 (p, J = 6.4 Hz, 1 H), 4.12 (s, 2H), 1 .42 (d, J = 6.3 Hz, 6H).
808 1 H NMR (400 MHz, Methanol-d4) δ 8.80 (d, J = 2.1 Hz, 1 H), 8.74 (d, J = 2.1 Hz,
1 H), 8.58 (s, 1 H), 8.33 (s, 1 H), 7.97 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 4.04 (s, 2H), 2.28 (t, J = 8.0 Hz, 6H), 1.94 (t, J = 8.0 Hz, 6H), 1.53 (s, 9H).
809
810 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.1 Hz,
1 H), 8.56 (s, 1 H), 8.28 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.55 (s, 2H), 2.32 - 2.14 (m, 6H), 1.88 (dt, J = 12.7, 7.3 Hz, 6H), 1.37 (s, 6H).
811 1 H NMR (400 MHz, Methanol-d4) δ 8.80 (d, J = 2.1 Hz, 1 H), 8.74 (d, J = 2.1 Hz,
1 H), 8.67 (s, 1 H), 8.34 (s, 1 H), 8.14 - 8.06 (m, 2H), 7.98 (d, J = 5.1 Hz, 1 H), 7.71 (t, J = 7.5 Hz, 1 H), 7.60 (t, J = 7.7 Hz, 2H), 7.26 (d, J = 5.1 Hz, 1 H), 4.94 (s, 2H), 2.28 (t, J = 7.8 Hz, 6H), 1.93 (t, J = 8.0 Hz, 6H).
812 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.1 Hz, 1 H), 8.69 (d, J = 2.1 Hz,
1 H), 8.60 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.88 (s, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 4.19 (p, J = 6.5 Hz, 1 H), 4.06 (s, 2H), 1 .54 (s, 9H), 1.43 (d, J = 6.4 Hz, 6H).
813 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.32 (s, 1 H), 7.95 (d, J = 5.0 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 3.98 (s, 2H), 2.34 - 2.22 (m, 6H), 1.93 (t, J = 8.0 Hz, 6H), 1.39 (s, 9H).
814 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.32 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.0 Hz, 1 H), 4.22 (s, 2H), 3.03 (s, 3H), 2.28 (t, J = 7.8 Hz, 6H), 1.93 (t, J = 7.9 Hz, 6H), 1.49 (s, 9H).
815 1 H NMR (400 MHz, Methanol-d4) δ 8.80 (d, J = 6.9 Hz, 2H), 8.62 (s, 1 H), 8.03 (d,
J = 5.1 Hz, 1 H), 7.84 (s, 1 H), 7.25 (d, J = 5.0 Hz, 1 H), 4.62 (s, 2H), 4.55 - 4.40 (m, 1 H), 3.71 (s, 4H), 3.38 (d, J =
7.5 Hz, 2H), 2.57 (s, 1 H), 2.49 (t, J = 10.5 Hz, 2H), 2.29 (q, J = 10.5, 9.8 Hz, 2H), 1 .41 (s, 6H).
816 1 H NMR (400 MHz, Methanol-d4) δ 8.82 - 8.75 (m, 2H), 8.55 (s, 1 H), 8.01 (d, J =
5.1 Hz, 1 H), 7.82 (s, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 4.53 - 4.39 (m, 1 H), 3.71 (s, 3H), 3.44 (t, J = 8.0 Hz, 2H), 3.38 (d, J = 7.5 Hz, 2H), 2.57 (s, 1 H), 2.49 (s, 2H), 2.28 (q, J = 10.0, 9.5 Hz, 2H), 2.04 (q, J = 7.3, 6.5 Hz, 2H), 1 .46 (s, 9H), 1 .34 (s, 6H).
817 1 H NMR (400 MHz, Methanol-d4) δ 8.58 - 8.49 (m, 2H), 8.23 (dd, J = 9.2, 1 .8 Hz,
1 H), 7.96 (d, J = 5.0 Hz, 1 H), 7.74 (s, 1 H), 7.10 (dd, J = 9.1 , 4.5 Hz, 1 H), 6.94 (d, J = 5.0 Hz, 1 H), 4.51 (dd, J = 9.3, 2.1 Hz, 1 H), 4.39 (d, J = 9.4 Hz, OH), 4.18 (p, J = 6.4 Hz, 1 H), 4.06 - 3.84 (m, 1 H), 3.50 (td, J = 15.4, 9.3 Hz, 1 H), 1.42 (d, J = 6.4 Hz, 6H), 1.32 (d, J = 1 .7 Hz, 6H).
818 1 H NMR (400 MHz, Methanol-d4) δ 8.56 (d, J = 4.4 Hz, 1 H), 8.51 (s, 1 H), 8.20 (dd,
J = 9.1 , 1.8 Hz, 1 H), 7.92 (d, J = 5.0 Hz, 1 H), 7.57 (s, 1 H), 7.08 (dd, J = 9.1 , 4.5 Hz, 1 H), 6.91 (d, J = 5.0 Hz, 1 H), 4.52 - 4.31 (m, 2H), 3.93 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.66 (s, 3H), 3.56 - 3.40 (m, 1 H), 2.55 (s, 1 H), 2.44 (d, J = 8.9 Hz, 2H), 2.24 (q, J = 9.6 Hz, 2H), 1 .29 (d, J = 1.6 Hz, 6H).
819 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 1 H), 8.73 (d, J = 2.2 Hz, 1 H), 8.57 (s,
1 H), 7.97 (d, J = 5.1 Hz, 1 H), 7.85 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 4.41 (q, J = 6.7, 6.0 Hz, 1 H), 3.68 (s, 3H), 3.55 - 3.46 (m, 2H), 3.35 (d, J = 7.4 Hz, 2H), 2.54 (s, 1 H), 2.47 (t, J = 10.1 Hz, 2H), 2.22 (q, J = 10.1 , 9.6 Hz, 2H), 2.04 - 1.92 (m, 2H), 1 .42 (s, 6H).
820 1 H NMR (400 MHz, Methanol-d4) δ 8.98 (dd, J = 4.6, 1.6 Hz, 1 H), 8.77 (s, 1 H),
8.68 (d, J = 2.2 Hz, 1 H), 8.59 (d, J = 8.2 Hz, 1 H), 8.45 (d, J = 2.2 Hz, 1 H), 8.36 (s, 1 H), 8.26 (d, J = 9.0 Hz, 1 H), 8.15 (d, J = 2.4 Hz, 1 H), 7.96 (dd, J = 9.0, 2.4 Hz, 1 H), 7.81 (d, J = 5.1 Hz, 1 H), 7.74 (dd, J = 8.3, 4.5 Hz, 1 H), 7.14 (d, J = 5.0 Hz, 1 H), 4.59 - 4.36 (m, 1 H), 4.11 - 3.91 (m, 1 H), 3.62 - 3.49 (m, 1 H), 1 .30 (d, J = 1.6 Hz, 6H).
821 1 H NMR (400 MHz, Methanol-d4) δ 10.50 (s, 1 H), 9.32 (s, 1 H), 8.95 (s, 1 H), 8.68
(d, J = 6.6 Hz, 1 H), 8.63 (d, J = 1.5 Hz, 2H), 8.49 (d, J = 9.1 Hz, 1 H), 8.05 (d, J = 6.7 Hz, 1 H), 7.98 (d, J = 4.9 Hz,
1 H), 7.45 (d, J = 9.0 Hz, 1 H), 7.15 (d, J = 4.8 Hz, 1 H), 4.56 - 4.34 (m, 1 H), 4.05 - 3.83 (m, 1 H), 3.54 (dd, J = 14.9, 8.8 Hz, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
822 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.63 (s, 1 H), 8.05 (d, J = 5.0 Hz, 1 H), 7.94 (s, 1 H), 7.25 (d, J = 5.0 Hz, 1 H), 4.57 - 4.30 (m, 1 H), 4.14 (s, 2H), 3.92 (dt, J = 37.2, 14.1 Hz, 4H), 3.52 (td, J = compound 1 H-NMR
15.2, 9.2 Hz, 2H), 3.40 (d, J = 12.3 Hz, OH), 2.49 - 2.25 (m, 4H), 1.87 (h, J = 10.7 Hz, 2H), 1 .64 (q, J = 12.3, 11.9 Hz, 2H), 1.31 (d, J = 1 .8 Hz, 6H). (several protons obscured by solvent peak)
823 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (q, J = 2.2 Hz, 2H), 8.57 (s, 1 H), 7.99 (d,
J = 5.1 Hz, 1 H), 7.77 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.53 - 4.34 (m, 2H), 4.02 - 3.85 (m, 3H), 3.57 - 3.46 (m, 3H), 3.44 (s, 3H), 2.69 - 2.56 (m, 1 H), 2.54 - 2.40 (m, 2H), 2.35 - 2.19 (m, 2H), 1.30 (d, J = 1.7 Hz, 6H).
824 1 H NMR (400 MHz, Methanol-d4) δ 8.80 (d, J = 2.2 Hz, 1 H), 8.75 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.00 (d, J = 5.1 Hz, 1 H), 7.81 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.52 - 4.34 (m, 2H), 3.94 (ddd, J =
36.3, 14.6, 2.2 Hz, 1 H), 3.56 - 3.41 (m, 3H), 2.66 - 2.53 (m, 1 H), 2.51 - 2.40 (m, 2H), 2.32 - 2.17 (m, 2H), 1.30 (d, J = 1.7 Hz, 6H), 1.22 (s, 9H).
825 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 2H), 8.57 (s, 1 H), 7.99 (d, J = 5.1 Hz,
1 H), 7.78 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.53 - 4.31 (m, 2H), 3.94 (ddd, J = 36.3, 14.5, 2.2 Hz, 1 H), 3.56 - 3.41 (m, 3H), 2.67 - 2.52 (m, 1 H), 2.51 - 2.40 (m, 2H), 2.34 - 2.23 (m, 2H), 2.25 - 2.18 (m, 2H), 1.68 (h, J = 7.4 Hz, 2H), 1.30 (d, J = 1.7 Hz, 6H), 0.96 (t, J = 7.4 Hz, 3H).
826 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 2H), 8.58 (s, 1 H), 7.99 (d, J = 5.1 Hz,
1 H), 7.79 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.54 - 4.34 (m, 2H), 3.94 (ddd, J = 36.3, 14.5, 2.2 Hz, 1 H), 3.58 - 3.41 (m, 3H), 2.69 - 2.51 (m, 1 H), 2.51 - 2.41 (m, 2H), 2.34 - 2.22 (m, 2H), 2.17 - 2.04 (m, 3H), 1.30 (d, J = 1 .7 Hz, 6H), 1.02 - 0.88 (m, 6H).
827 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.70 (m, 2H), 8.57 (s, 1 H), 8.00 (d, J =
5.1 Hz, 1 H), 7.79 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.56 - 4.29 (m, 2H), 3.94 (ddd, J = 36.3, 14.5, 2.2 Hz, 1 H), 3.58 - 3.41 (m, 3H), 2.70 - 2.54 (m, 1 H), 2.52 - 2.38 (m, 2H), 2.33 - 2.16 (m, 2H), 1.35 (s, 3H), 1.30 (d, J = 1.7 Hz, 6H), 1.13 (q, J = 3.8 Hz, 2H), 0.69 - 0.58 (m, 2H).
828 1 H NMR (400 MHz, Methanol-d4) δ 8.80 - 8.68 (m, 2H), 8.57 (s, 1 H), 8.04 - 7.91
(m, 1 H), 7.80 (s, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.54 - 4.30 (m, 2H), 3.95 (ddd, J = 36.3, 14.5, 2.2 Hz, 1 H), 3.66 - 3.41 (m, 3H), 2.76 - 2.58 (m, 1 H), 2.56 - 2.41 (m, 2H), 2.39 - 2.21 (m, 2H), 1.37 - 1 .33 (m, 2H), 1.32 - 1.28 (m, 8H).
829 1 H NMR (400 MHz, Methanol-d4) δ 8.81 - 8.67 (m, 2H), 8.57 (s, 1 H), 7.98 (d, J =
5.1 Hz, 1 H), 7.81 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.56 - 4.31 (m, 2H), 3.94 (ddd, J = 36.3, 14.5, 2.2 Hz, 1 H), 3.65 - 3.41 (m, 3H), 2.73 - 2.54 (m, 1 H), 2.52 - 2.41 (m, 2H), 2.34 - 2.18 (m, 2H), 1.36 - 1 .32 (m, 2H), 1.31 - 1.27 (m, 8H).
830 1 H NMR (400 MHz, Methanol-d4) δ 8.85 - 8.71 (m, 2H), 8.56 (s, 1 H), 7.98 (d, J =
5.0 Hz, 1 H), 7.82 (s, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.52 - 4.31 (m, 1 H), 4.05 - 3.81 (m, 1 H), 3.82 - 3.58 (m, 4H), 3.36 (d, J = 7.4 Hz, 2H), 2.71 - 2.52 (m, 1 H), 2.53 - 2.41 (m, 2H), 2.33 - 2.21 (m, 2H), 2.17 - 1.89 (m, 4H), 1.67 - 1.29 (m, 5H), 0.90 - 0.79 (m, 2H), 0.78 - 0.67 (m, 2H).
831 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.72 (m, 2H), 8.57 (s, 1 H), 7.97 (d, J =
5.0 Hz, 1 H), 7.85 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.56 - 4.25 (m, 2H), 3.95 (ddd, J = 36.3, 14.6, 2.1 Hz, 1 H), 3.62 - 3.41 (m, 1 H), 3.32 - 3.26 (m, 2H), 3.01 (s, 3H), 2.71 - 2.50 (m, 3H), 2.41 - 2.22 (m, 2H), 1.30 (d, J = 1 .6 Hz, 6H).
832 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.1 Hz, 1 H), 8.65 (d, J = 2.1 Hz,
1 H), 8.59 (s, 1 H), 8.02 (d, J = 5.1 Hz, 1 H), 7.91 - 7.83 (m, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.64 - 4.25 (m, 1 H), 4.03 - 3.81 (m, 2H), 3.66 - 3.40 (m, 1 H), 2.43 (dd, J = 8.7, 7.4 Hz, 2H), 2.27 - 2.01 (m, 4H), 1.96 - 1 .59 (m, 6H), 1.30 (d, J = 1 .6 Hz, 6H).
833 1 H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.71 (m, 2H), 8.58 (s, 1 H), 8.51 (s, 1 H),
7.91 (d, J = 5.1 Hz, 1 H), 7.23 (d, J = 5.1 Hz, 1 H), 4.41 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 3.92 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.66 - 3.54 (m, 1 H), 3.54 - 3.39 (m, 2H), 2.57 (ddd, J = 13.5, 10.8, 7.8 Hz, 1 H), 2.28 (s, 6H), 2.1 1 - 1.97 (m, 1 H), 1 .88 - 1 .68 (m, 1 H), 1.31 - 1.22 (m, 6H).
834 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (s, 2H), 8.55 (s, 1 H), 8.31 (s, 1 H), 7.83 (d,
J = 5.1 Hz, 1 H), 7.57 (t, J = 8.2 Hz, 1 H), 7.30 (d, J = 8.0 Hz, 2H), 7.17 (d, J = 5.1 Hz, 1 H), 4.60 - 4.33 (m, 3H), 3.99 (dd, J = 36.5, 14.5 Hz, 1 H), 3.70 (s, 3H), 3.53 (td, J = 15.2, 9.2 Hz, 1 H), 1.30 (d, J = 1 .6 Hz, 6H).
835 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.72 (d, J = 2.2 Hz, 1 H), 8.57 (d,
J = 2.1 Hz, 1 H), 8.37 (d, J = 2.1 Hz, 1 H), 8.33 (d, J = 2.5 Hz, 1 H), 8.26 (s, 1 H), 7.85 (d, J = 5.1 Hz, 1 H), 7.64 (t, J = 2.3 Hz, 1 H), 7.18 (d, J = 5.1 Hz, 1 H), 4.62 - 4.34 (m, 1 H), 4.22 (q, J = 7.0 Hz, 2H), 4.08 - 3.87 (m, 1 H), 3.64 - 3.42 (m, 1 H), 1 .48 (t, J = 7.0 Hz, 3H), 1.31 (d, J = 1.7 Hz, 6H).
836 1 H NMR (400 MHz, Methanol-d4) δ 8.70 (s, 1 H), 8.66 (d, J = 2.2 Hz, 1 H), 8.46 (d,
J = 2.1 Hz, 1 H), 8.39 (s, 1 H), 7.78 (d, J = 5.0 Hz, 1 H), 7.45 (t, J = 8.2 Hz, 1 H), 7.14 (d, J = 5.0 Hz, 1 H), 7.08 - 6.98 (m, 2H), 6.93 (d, J = 8.4 Hz, 1 H), 4.47 (dd, J = 48.9, 9.0 Hz, 1 H), 4.1 1 (q, J = 7.0 Hz, 2H), 3.98 (dd, J = 36.1 , 14.5 Hz, 1 H), 3.60 - 3.44 (m, 1 H), 1.44 (t, J = 7.0 Hz, 3H), 1.31 (d, J = 1.7 Hz, 6H).
837 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.63 (m, 2H), 8.49 (d, J = 2.2 Hz, 1 H), compound 1H-NMR
8.31 (s, 1H), 7.77 (d, J =5.0 Hz, 1H), 7.46 (t, J =8.1 Hz, 1H), 7.15 (d, J =5.1 Hz, 1 H), 7.08 - 6.77 (m, 3H), 4.69 (p, J = 6.0 Hz, 1 H), 4.58 - 4.29 (m, 1 H), 3.99 (dd, J = 36.3, 14.5 Hz, 1H), 3.58-3.41 (m, 1H), 1.36 (d, J =6.0 Hz, 6H), 1.31 (d, J = 1.7 Hz, 6H).
838 1 H NMR (400 MHz, Methanol-d4) δ 8.81 - 8.65 (m, 2H), 8.49 (d, J = 2.1 Hz, 1 H),
8.09 (s, 1 H), 7.73 (d, J = 5.1 Hz, 1 H), 7.52 (t, J = 7.8 Hz, 1 H), 7.32 (dd, J = 8.1 , 1.9 Hz, 1H), 7.29-7.22 (m, 2H), 7.16 (d, J =5.1 Hz, 1H), 4.59-4.35 (m, 1H), 4.12- 3.87 (m, 1H), 3.53 (td, J = 15.3, 9.3 Hz, 1H), 2.59 (d, J = 7.2 Hz, 2H), 2.05-1.82 (m, 1 H), 1.31 (d, J = 1.7 Hz, 6H), 0.94 (d, J = 6.6 Hz, 6H).
839 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (s, 1 H), 8.68 (d, J = 2.2 Hz, 1 H), 8.50 (d,
J =2.2 Hz, 1H), 8.32 (s, 1H), 8.12 (d, J =2.2 Hz, 1H), 8.03 (d, J = 7.3 Hz, 1H), 7.79 (d, J = 5.1 Hz, 1H), 7.75-7.61 (m, 2H), 7.15 (d, J = 5.1 Hz, 1H), 4.48 (dd, J = 49.5, 8.9 Hz, 1H), 4.00 (dd, J =36.5, 14.6 Hz, 1H), 3.54 (td, J = 15.7, 9.5 Hz, 1H), 3.14 (q, J = 7.2 Hz, 2H), 1.31 (d, J = 1.6 Hz, 6H), 1.23 (t, J
= 7.2 Hz, 3H).
840 1 H NMR (400 MHz, Methanol-d4) δ 9.44 (s, 1 H), 8.76 (s, 1 H), 8.72 (s, 1 H), 8.67 (s,
1H), 8.23 (s, 1H), 8.21 (s, 1H), 7.89 (d, J =5.1 Hz, 1H), 7.19 (d, J =5.0 Hz, 1H), 4.64-4.29 (m, 1H), 4.03 (s, 4H), 3.55 (td, J = 15.5, 9.3 Hz, 1H), 1.32 (s, 6H).
841 1 H NMR (400 MHz, Methanol-d4) δ 9.43 (s, 1 H), 8.74 (s, 1 H), 8.71 (s, 1 H), 8.65 (d,
J =2.1 Hz, 1H), 8.18 (s, 1H), 8.16 (s, 1H), 7.88 (d, J =5.1 Hz, 1H), 7.17 (d, J = 5.1 Hz, 1H), 4.61 - 4.34 (m, 3H), 4.00 (dd, J = 36.2, 14.5 Hz, 1H), 3.55 (td, J = 15.4, 9.2 Hz, 1 H), 1.44 (t, J = 7.1 Hz, 3H), 1.32 (s, 6H).
842 1 H NMR (400 MHz, Methanol-d4) δ 9.53 (s, 1 H), 8.84 (s, 1 H), 8.75 (d, J = 2.1 Hz,
1 H), 8.65 (d, J = 2.1 Hz, 1 H), 8.11 (s, 1 H), 8.03 (s, 1 H), 7.89 (d, J = 5.0 Hz, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.60 - 4.32 (m, 1 H), 4.16 - 3.80 (m, 4H), 3.57 (td, J = 15.4, 9.3 Hz, 1H), 1.32 (s, 6H).
843 1 H NMR (400 MHz, Methanol-d4) δ 9.86 (s, 1 H), 8.98 (s, 1 H), 8.66 (d, J = 2.2 Hz,
1 H), 8.55 (d, J = 2.2 Hz, 1 H), 8.47 (d, J = 6.8 Hz, 1 H), 7.96 (d, J = 4.9 Hz, 1 H), 7.25-7.05 (m, 2H), 4.65-4.24 (m, 1H), 3.94 (dd, J = 36.1, 14.5 Hz, 1H), 3.56 (td, J = 15.3, 9.2 Hz, 1H), 2.98 (t, J = 7.7 Hz, 2H), 2.12-1.66 (m, 2H), 1.30 (s, 6H), 1.00 (t, J =7.4 Hz, 3H).
844 1 H NMR (400 MHz, Methanol-d4) δ 9.89 (s, 1 H), 8.90 (s, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.60 (d, J = 2.3 Hz, 1 H), 8.35 (d, J = 6.0 Hz, 1 H), 7.94 (d, J = 5.0 Hz, 1 H), 7.17 (d, J = 5.0 Hz, 1H), 6.83 (d, J =6.1 Hz, 1H), 4.46 (dd, J =49.0, 9.3 Hz, 1H), 4.11 (s, 3H), 3.97 (dd, J =36.3, 14.7 Hz, 1H), 3.66-3.46 (m, 1H), 1.31 (s, 6H).
845 1 H NMR (400 MHz, Methanol-d4) δ 9.52 (s, 1 H), 8.83 (s, 1 H), 8.74 (d, J = 2.0 Hz,
1 H), 8.64 (d, J = 1.7 Hz, 1 H), 8.08 (s, 1 H), 7.97 (d, J = 1.4 Hz, 1 H), 7.87 (d, J = 5.0 Hz, 1H),7.21 (d, J = 5.0 Hz, 1 H), 4.63 - 4.35 (m, 3H), 4.00 (dd, J = 36.2, 15.0 Hz, 1H), 3.71 -3.43 (m, 1H), 1.41 (t, J =7.1 Hz, 3H), 1.32 (s, 6H).
846 1H NMR (400 MHz, Methanol-d4) δ 10.05 (s, 1H), 8.81 (s, 1H), 8.73-8.61 (m, 3H),
7.93 (d, J = 5.0 Hz, 1H), 7.19 (d, J =5.1 Hz, 1H), 6.57 (s, 1H), 4.62-4.29 (m, 1H), 4.14-3.82 (m, 4H), 3.70-3.44 (m, 1H), 1.31 (s, 6H).
847 1 H NMR (400 MHz, Methanol-d4) δ 8.87 (s, 1 H), 8.84 (s, 1 H), 8.67 (d, J = 2.2 Hz,
1H), 8.57 (d, J =2.2 Hz, 1H), 8.16 (d, J =6.5 Hz, 1H), 7.93 (d, J =4.9 Hz, 1H), 7.16 (d, J = 4.4 Hz, 2H), 6.99 (d, J = 1.8 Hz, 1H), 4.53-4.31 (m, 3H), 3.95 (dd, J = 36.2, 14.6 Hz, 1H), 3.53 (td, J = 15.3, 9.4 Hz, 1H), 1.49 (t, J =7.0 Hz, 3H), 1.29 (s, 6H).
848 1 H NMR (400 MHz, Methanol-d4) δ 9.88 (s, 1 H), 8.89 (s, 1 H), 8.67 (d, J = 2.2 Hz,
1 H), 8.59 (d, J = 2.1 Hz, 1 H), 8.32 (d, J = 6.2 Hz, 1 H), 7.91 (d, J = 5.0 Hz, 1 H), 7.17 (d, J = 4.9 Hz, 1H), 6.80 (d, J =6.1 Hz, 1H), 4.61 -4.30 (m, 3H), 3.96 (dd, J = 36.2, 14.5 Hz, 1H), 3.55 (td, J = 15.3, 9.3 Hz, 1H), 1.41 (t, J =7.1 Hz, 3H), 1.31 (s, 5H).
849 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.72 (d, J = 2.2 Hz, 1 H), 8.56 (d,
J = 2.2 Hz, 1 H), 8.36 (d, J = 2.0 Hz, 1 H), 8.33 (d, J = 2.5 Hz, 1 H), 8.27 (s, 1 H), 7.85 (d, J = 5.1 Hz, 1H), 7.65 (d, J =2.4 Hz, 1H), 7.18 (d, J =5.0 Hz, 1H), 4.62- 4.35 (m, 1H), 4.12 (t, J = 6.5 Hz, 2H), 4.00 (dd, J =36.6, 14.3 Hz, 1H), 3.54 (td, J = 15.5, 9.6 Hz, 1 H), 1.88 (h, J = 7.0 Hz, 2H), 1.31 (d, J = 1.7 Hz, 6H), 1.09 (t, J = 7.4 Hz, 3H).
850 1 H NMR (400 MHz, Methanol-d4) δ 8.77 - 8.66 (m, 2H), 8.58 (d, J = 2.1 Hz, 1 H),
8.05 (s, 1 H), 7.90 (d, J = 2.3 Hz, 1 H), 7.83 (d, J = 5.1 Hz, 1 H), 7.49 (d, J = 2.4 Hz, 1H), 7.17 (d, J =5.1 Hz, 1H), 4.60-4.31 (m, 5H), 3.99 (dd, J =36.4, 14.5 Hz, 1H), 3.53 (td, J = 15.2, 9.2 Hz, 1 H), 1.30 (s, 6H).
851 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (s, 1 H), 8.72 (d, J = 2.2 Hz, 1 H), 8.56 (d,
J = 2.2 Hz, 1 H), 8.34 (d, J = 2.1 Hz, 1 H), 8.30 (d, J = 2.5 Hz, 1 H), 8.25 (s, 1 H), 7.85 (d, J = 5.0 Hz, 1H), 7.62 (d, J =2.9 Hz, 1H), 7.18 (d, J =5.0 Hz, 1H), 4.82- 4.71 (m, 1H), 4.58-4.35 (m, 1H), 4.00 (dd, J =36.4, 14.6 Hz, 1H), 3.54 (td, J = 16.5, 15.9, 10.0 Hz, 1H), 1.40 (d, J =6.0 Hz, 6H), 1.31 (s, 6H).
852 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (s, 1 H), 8.72 (d, J = 2.2 Hz, 1 H), 8.56 (d, compound 1H-NMR
J = 2.1 Hz, 1 H), 8.42 (d, J = 2.0 Hz, 1 H), 8.40 (d, J = 2.6 Hz, 1 H), 8.27 (s, 1 H), 7.86 (d, J = 5.1 Hz, 1H), 7.73 (d, J = 2.4 Hz, 1H), 7.18 (d, J =5.0 Hz, 1H), 6.65- 5.80 (m, 1H), 4.57-4.39 (m, 3H), 4.00 (dd, J =36.5, 14.6 Hz, 1H), 3.55 (td, J = 15.5, 9.4 Hz, 1H), 1.31 (s, 6H).
853 1 H NMR (400 MHz, Methanol-d4) δ 8.74 - 8.66 (m, 2H), 8.51 (d, J = 2.2 Hz, 1 H),
7.95 (s, 1 H), 7.83 (d, J = 2.2 Hz, 1 H), 7.81 (d, J = 5.1 Hz, 1 H), 7.35 (d, J = 2.2 Hz, 1H), 7.16 (d, J =5.1 Hz, 1H), 4.60-4.36 (m, 1H), 4.03 (s, 4H), 3.89 (s, 3H), 3.53 (td, J = 15.6, 9.5 Hz, 1H), 1.31 (d, J = 1.8 Hz, 6H).
854 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.2 Hz, 1 H), 8.63 (s, 1 H), 8.53 (d,
J =2.2 Hz, 1H), 8.06 (s, 1H), 7.73 (d, J =5.0 Hz, 1H), 7.16 (d, J = 5.0 Hz, 1H), 6.96 - 6.76 (m, 3H), 4.46 (dd, J = 48.9, 9.3 Hz, 1 H), 4.34 (t, J = 4.3 Hz, 2H), 3.98 (dd, J = 36.5, 14.6 Hz, 1H), 3.52 (td, J = 15.3, 9.2 Hz, 1H), 3.35 (t, J = 4.5 Hz, 2H), 2.96 (s, 3H), 1.30 (s, 6H).
855 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.66 (m, 2H), 8.56 (s, 1 H), 7.99 (s, 1 H),
7.84 (d, J = 5.0 Hz, 1H), 7.73 (d, J =2.3 Hz, 1H), 7.33 (d, J =2.2 Hz, 1H), 7.17 (d, J = 5.0 Hz, 1 H), 4.46 (dd, J = 49.1 , 9.2 Hz, 1 H), 4.33 (t, J = 4.4 Hz, 2H), 3.98 (dd, J = 36.4, 14.6 Hz, 1H), 3.66 (t, J = 4.5 Hz, 2H), 3.58-3.44 (m, 1H), 1.30 (d, J = 1.8 Hz, 6H).
856 1 H NMR (400 MHz, Methanol-d4) δ 8.72 (d, J = 2.2 Hz, 1 H), 8.69 (s, 1 H), 8.55 (d,
J = 2.2 Hz, 1 H), 7.96 (s, 1 H), 7.82 (d, J = 5.0 Hz, 1 H), 7.78 (d, J = 2.3 Hz, 1 H), 7.22 (d, J = 2.3 Hz, 1 H), 7.17 (d, J = 5.0 Hz, 1 H), 4.47 (dd, J = 49.2, 9.4 Hz, 1 H), 4.37 - 4.25 (m, 2H), 3.98 (dd, J = 36.5, 14.7 Hz, 1 H), 3.72 - 3.61 (m, 2H), 3.53 (td, J = 15.3, 9.3 Hz, 1H), 3.23 (s, 3H), 1.30 (s, 6H).
857 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (s, 1 H), 8.73 (d, J = 2.2 Hz, 1 H), 8.56 (d,
J = 2.2 Hz, 1 H), 8.47 (d, J = 2.1 Hz, 1 H), 8.43 (d, J = 2.6 Hz, 1 H), 8.25 (s, 1 H), 7.86 (d, J = 5.0 Hz, 1H), 7.75 (d, J =2.5 Hz, 1H), 7.18 (d, J =5.0 Hz, 1H), 4.79 (q, J = 8.4 Hz, 2H), 4.57 - 4.36 (m, 1 H), 4.00 (dd, J = 36.5, 14.5 Hz, 1 H), 3.55 (td, J = 15.4, 9.4 Hz, 1H), 1.31 (d, J = 1.8 Hz, 6H).
858 1 H NMR (400 MHz, Methanol-d4) δ 8.80 - 8.66 (m, 2H), 8.57 (d, J = 2.2 Hz, 1 H),
8.05 (s, 1 H), 7.89 (d, J = 2.4 Hz, 1 H), 7.82 (d, J = 5.1 Hz, 1 H), 7.48 (d, J = 2.4 Hz, 1H), 7.17 (d, J =5.0 Hz, 1H), 4.62-4.52 (m, 2H), 4.39 (t, J = 3.9 Hz, 2H), 4.05- 3.84 (m, 1H), 3.76-3.62 (m, 1H), 2.17 - 1.91 (m, 4H), 1.64- 1.30 (m, 5H), 0.92- 0.80 (m, 2H), 0.77 - 0.66 (m, 2H).
859 1 H NMR (400 MHz, Methanol-d4) δ 8.70 (d, J = 2.2 Hz, 1 H), 8.60 (s, 1 H), 8.52 (d,
J =2.1 Hz, 1H), 8.06 (s, 1H), 7.73 (d, J =5.0 Hz, 1H), 7.15 (d, J = 5.0 Hz, 1H), 6.94 - 6.74 (m, 3H), 4.34 (t, J = 4.3 Hz, 2H), 4.00 - 3.83 (m, 1 H), 3.69 (t, J = 11.7 Hz, 1 H), 3.42 - 3.31 (m, 2H), 2.96 (s, 3H), 2.05 (dd, J = 35.2, 12.4 Hz, 4H), 1.74 (p, J =6.3 Hz, 1H), 1.68- 1.32 (m, 4H), 0.87-0.81 (m, 2H), 0.76-0.71 (m, 2H).
860 1 H NMR (400 MHz, Methanol-d4) δ 8.70 (d, J = 2.2 Hz, 1 H), 8.61 (s, 1 H), 8.52 (d,
J =2.1 Hz, 1H), 8.06 (s, 1H), 7.73 (d, J =5.0 Hz, 1H), 7.15 (d, J = 5.0 Hz, 1H), 6.93 - 6.72 (m, 3H), 4.34 (t, J = 4.3 Hz, 2H), 3.97 - 3.84 (m, 1 H), 3.70 - 3.54 (m, 5H), 3.47-3.33 (m, 6H), 2.96 (s, 3H), 2.05 (dd, J =34.3, 12.0 Hz, 4H), 1.48 (dp, J = 25.2, 12.7 Hz, 4H).
861 1 H NMR (400 MHz, Methanol-d4) δ 8.75 - 8.63 (m, 2H), 8.57 (d, J = 2.2 Hz, 1 H),
8.05 (s, 1 H), 7.89 (d, J = 2.4 Hz, 1 H), 7.82 (d, J = 5.0 Hz, 1 H), 7.48 (d, J = 2.4 Hz, 1H), 7.17 (d, J =5.0 Hz, 1H), 4.55 (t, J =4.0 Hz, 2H), 4.38 (t, J = 4.0 Hz, 2H), 3.93 (s, 1H), 3.72-3.52 (m, 5H), 3.37 (t, J =4.8 Hz, 4H), 2.18 - 1.93 (m, 4H), 1.62- 1.35 (m, 4H).
862 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (s, 1 H), 8.72 (d, J = 2.2 Hz, 1 H), 8.64 - 8.52 (m, 2H), 8.13 (s, 1H), 7.85 (d, J = 5.0 Hz, 1H), 7.76 (d, J = 2.4 Hz, 1H), 7.17 (d, J = 5.0 Hz, 1 H), 4.47 (dd, J = 49.2, 9.2 Hz, 1 H), 4.15 (t, J = 5.8 Hz, 2H), 3.99 (dd, J = 36.5, 14.6 Hz, 1H), 3.54 (td, J = 15.6, 9.5 Hz, 1H), 3.09 (t, J = 5.9 Hz, 2H), 1.30 (d, J = 1.8 Hz, 6H). Two protons hiding under solvent peaks.
863 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (s, 1 H), 8.71 (d, J = 2.2 Hz, 1 H), 8.52 (d,
J = 2.2 Hz, 1 H), 8.24 (s, 1 H), 7.80 (d, J = 5.1 Hz, 1 H), 7.64 (d, J = 8.4 Hz, 1 H), 7.53 (d, J = 7.2 Hz, 2H), 7.16 (d, J = 5.0 Hz, 1 H), 4.71 (s, 4H), 4.46 (ddd, J = 48.9, 9.4, 2.1 Hz, 1 H), 4.11 - 3.85 (m, 1 H), 3.63 - 3.45 (m, 1 H), 1.30 (d, J = 1.6 Hz, 6H).
864 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 1 H), 8.72 (d, J = 2.2 Hz, 1 H), 8.55 (d,
J = 2.2 Hz, 1 H), 8.20 (s, 1 H), 7.81 (d, J = 5.1 Hz, 1 H), 7.64 (d, J = 8.2 Hz, 1 H), 7.61 - 7.51 (m, 2H), 7.17 (d, J = 5.1 Hz, 1 H), 5.02 (dd, J = 8.4, 6.7 Hz, 2H), 4.83 - 4.78 (m, 6H), 4.72 (d, J = 5.7 Hz, 1 H), 4.46 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 3.97 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.54 (ddd, J = 16.1 , 14.5, 9.4 Hz, 1H), 1.30 (d, J = 1.6 Hz, 6H).
865 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.5 Hz, 2H), 8.53 (d, J = 2.2 Hz,
1H), 8.21 (s, 1H), 8.14 (s, 1H), 7.89 (s, 1H), 7.83 (d, J =5.0 Hz, 1H), 7.18 (d, J = 5.1 Hz, 1 H), 5.55 (t, J = 8.5 Hz, 1 H), 4.46 (dd, J = 49.0, 9.2 Hz, 1 H), 4.33 - 4.06 (m, 2H), 4.05-3.84 (m, 3H), 3.53 (td, J = 15.6, 9.5 Hz, 1H), 1.29 (d, J = 1.6 Hz, 6H).
866 1 H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 2.2 Hz, 1 H), 8.65 (s, 1 H), 8.57 (d,
J =2.1 Hz, 1H), 8.24 (s, 1H), 7.79 (d, J =5.1 Hz, 1H), 7.49-7.34 (m, 4H), 7.15 (d, compound 1H-NMR
J =5.1 Hz, 1H), 4.01 - 3.82 (m, 1H), 3.69 (s, 3H), 2.09 (d, J = 12.2 Hz, 2H), 2.00 (d, J = 12.5 Hz, 2H), 1.65- 1.33 (m, 4H), 1.31 (s, 5H), 0.83 (q, J =3.5 Hz, 2H), 0.74 (dt, J =8.1, 3.2 Hz, 2H).
867 1 H NMR (400 MHz, Methanol-d4) δ 8.62 (d, J = 2.2 Hz, 1 H), 8.55 (s, 1 H), 8.53 (d,
J = 2.2 Hz, 1 H), 8.05 (s, 1 H), 7.80 (d, J = 4.9 Hz, 1 H), 7.05 (d, J = 4.9 Hz, 1 H), 4.43 (ddd, J =48.9, 9.1, 2.3 Hz, 1H), 4.19 (t, J = 7.3 Hz, 1H), 3.88 (ddd, J =35.6, 14.5, 2.3 Hz, 1H), 3.48 (ddd, J = 16.3, 14.4, 9.0 Hz, 1H), 3.34 (d, J =7.5 Hz, 2H), 2.50 (s, 1H), 2.40 (d, J =9.1 Hz, 2H), 2.13 (q, J =9.3 Hz, 2H), 1.29 (d, J = 1.6 Hz, 6H).
868 1 H NMR (400 MHz, Methanol-d4) δ 8.78 - 8.65 (m, 2H), 8.51 (d, J = 2.2 Hz, 1 H),
8.20 (s, 1H), 8.18 (s, 1H), 7.88 (s, 1H), 7.82 (d, J = 5.0 Hz, 1H), 7.17 (d, J = 5.0 Hz, 1H), 5.54 (t, J =8.1 Hz, 1H), 4.58-4.39 (m, 1H), 4.27 (d, J = 13.6 Hz, 1H), 4.11 (dd, J = 13.5, 7.1 Hz, 1H), 4.05-3.84 (m, 4H), 3.62-3.42 (m, 1H), 1.29 (d, J = 1.6 Hz, 7H).
869 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.2 Hz, 2H), 8.51 (d, J = 2.2 Hz,
1H), 8.20 (s, 1H), 8.17 (s, 1H), 7.89 (s, 1H), 7.83 (d, J =5.0 Hz, 1H), 7.17 (d, J = 5.0 Hz, 1 H), 5.54 (t, J = 8.5 Hz, 1 H), 4.46 (ddd, J = 49.2, 9.2, 2.1 Hz, 1 H), 4.34 - 4.23 (m, 1H), 4.12 (dd, J = 13.4, 7.0 Hz, 1H), 4.07-3.84 (m, 3H), 3.64-3.33 (m, 1H), 1.29 (d, J = 1.6 Hz, 6H).
870 1 H NMR (400 MHz, Methanol-d4) δ 8.70 (d, J = 2.2 Hz, 1 H), 8.69 (s, 1 H), 8.56 (d,
J = 2.2 Hz, 1 H), 8.21 (d, J = 2.6 Hz, 1 H), 7.92 (s, 1 H), 7.80 (d, J = 5.1 Hz, 1 H), 7.75 (dd, J =9.2, 2.7 Hz, 1H), 7.15 (d, J =5.1 Hz, 1H), 7.11 (d, J =9.2 Hz, 1H), 4.46 (ddd, J =49.1, 9.4, 2.0 Hz, 1H), 3.97 (ddd, J =36.6, 14.4, 2.1 Hz, 1H), 3.74 (s, 3H), 3.73 - 3.59 (m, 9H), 3.59 - 3.41 (m, 1 H), 1.29 (d, J = 1.6 Hz, 6H).
871 1 H NMR (400 MHz, Methanol-d4) δ 8.71 (d, J = 2.7 Hz, 2H), 8.53 (d, J = 2.2 Hz,
1H), 8.29 (d, J =2.7 Hz, 1H), 7.96 (s, 1H), 7.83-7.72 (m, 2H), 7.19-7.11 (m, 2H), 4.91 (d, J = 7.6 Hz, 4H), 4.56 - 4.37 (m, 2H), 4.06 - 3.88 (m, 5H), 3.60 - 3.45 (m, 1 H), 3.35 (s, 4H), 1.29 (d, J = 1.7 Hz, 6H).
872 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 1 H), 8.70 (d, J = 2.2 Hz, 1 H), 8.53 (d,
J = 2.2 Hz, 1 H), 8.33 (s, 1 H), 7.81 (d, J = 5.0 Hz, 1 H), 7.72 (d, J = 8.0 Hz, 2H), 7.64 - 7.56 (m, 2H), 7.16 (d, J = 5.0 Hz, 1 H), 6.55 - 6.14 (m, 1 H), 4.59 - 4.27 (m, 3H), 4.07-3.76 (m, 1H), 3.68-3.44 (m, 3H), 1.30 (d, J = 1.6 Hz, 6H).
873 1 H NMR (400 MHz, Methanol-d4) δ 8.63 (d, J = 2.2 Hz, 1 H), 8.56 (s, 1 H), 8.54 (d,
J = 2.2 Hz, 1 H), 8.04 (s, 1 H), 7.81 (d, J = 4.9 Hz, 1 H), 7.06 (d, J = 4.9 Hz, 1 H), 4.92 (d, J = 6.0 Hz, 2H), 4.56 - 4.30 (m, 3H), 4.23 (t, J = 7.3 Hz, 1 H), 3.88 (ddd, J = 35.5, 14.5, 2.3 Hz, 1H), 3.60-3.40 (m, 3H), 2.56 (d, J =7.3 Hz, 1H), 2.42 (ddd, J = 12.1, 7.5, 3.7 Hz, 2H), 2.16 (q, J =9.5 Hz, 2H), 1.61 (s, 3H), 1.29 (d, J = 1.6 Hz, 6H).
874 1 H NMR (400 MHz, Methanol-d4) δ 8.69 - 8.67 (m, 2H), 8.55 (d, J = 2.2 Hz, 1 H),
8.22 (s, 1H), 7.80 (d, J =5.1 Hz, 1H), 7.69-7.61 (m, 2H), 7.47 - 7.38 (m, 2H), 7.14 (d, J = 5.1 Hz, 1 H), 4.53 (dd, J = 9.3, 2.1 Hz, 1 H), 4.47 - 4.32 (m, 3H), 4.11 - 3.96 (m, 1 H), 3.92 (dd, J = 8.8, 7.1 Hz, 3H), 3.64 - 3.44 (m, 1 H), 1.76 (s, 6H), 1.30 (d, J = 1.6 Hz, 6H).
875 1 H NMR (400 MHz, Methanol-d4) δ 8.73 - 8.65 (m, 2H), 8.58 (d, J = 2.2 Hz, 1 H),
8.23 (s, 1 H), 7.82 (d, J = 5.1 Hz, 1 H), 7.55 (d, J = 8.6 Hz, 2H), 7.38 (d, J = 8.6 Hz, 2H), 7.14 (d, J =5.1 Hz, 1H), 4.47 (ddd, J = 49.0, 9.3, 2.1 Hz, 1H), 4.08-3.87 (m, 1H), 3.80 (t, J =7.0 Hz, 2H), 3.53 (ddd, J = 16.1, 14.5, 9.4 Hz, 1H), 2.41 (t, J =8.1 Hz, 2H), 2.20 - 2.06 (m, 2H), 1.74 (s, 6H), 1.30 (d, J = 1.6 Hz, 6H).
876 1 H NMR (400 MHz, Methanol-d4) δ 8.72 - 8.66 (m, 2H), 8.54 (d, J = 2.1 Hz, 1 H),
8.15 (s, 1H), 7.78 (d, J =5.1 Hz, 1H), 7.47 (q, J =8.7 Hz, 4H), 7.15 (d, J =5.1 Hz, 1H), 4.67-4.26 (m, 3H), 3.98 (ddd, J =36.5, 14.5, 2.1 Hz, 1H), 3.84-3.66 (m, 2H), 3.52 (ddd, J = 16.1, 14.6, 9.4 Hz, 1H), 1.59- 1.48 (m, 2H), 1.44- 1.32 (m, 2H), 1.30 (d, J = 1.6 Hz, 6H).
877 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (s, 1 H), 8.75 (d, J = 2.1 Hz, 1 H), 8.65 (d,
J =2.1 Hz, 1H), 8.15 (d, J =2.4 Hz, 1H), 8.07 (dd, J = 9.7, 2.5 Hz, 1H), 7.96 (s, 1H), 7.93 (d, J =5.1 Hz, 1H), 7.28 (d, J =9.6 Hz, 1H), 7.19 (d, J =5.0 Hz, 1H), 4.49 (ddd, J =49.1, 9.4, 2.0 Hz, 1H), 4.00 (ddd, J =36.5, 14.6, 2.1 Hz, 1H), 3.77 - 3.64 (m, 5H), 3.65-3.46 (m, 1H), 2.36 - 2.18 (m, 4H), 1.32 (d, J = 1.6 Hz, 6H).
878 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.72 (s, 2H), 8.23 (d, J = 2.4 Hz,
1H), 8.16 (s, 1H), 8.03 (d, J = 9.5 Hz, 1H), 7.87 (d, J =5.0 Hz, 1H), 7.42 (d, J =9.6 Hz, 1H), 7.19 (d, J = 5.0 Hz, 1H), 4.49 (dd, J =49.0, 8.9 Hz, 1H), 4.25 (s, 1H), 4.09 - 3.88 (m, 1 H), 3.76 (t, J = 8.3 Hz, 1 H), 3.67 - 3.45 (m, 3H), 3.28 - 3.06 (m, 1 H), 2.20 (d, J = 18.7 Hz, 3H), 2.08 (s, 4H), 1.33 (d, J =1.6 Hz, 6H).
879 1 H NMR (400 MHz, Methanol-d4) δ 8.82 - 8.71 (m, 2H), 8.68 (d, J = 2.2 Hz, 1 H),
8.18 (d, J = 2.5 Hz, 1H), 8.09 (s, 1H), 8.01 (d, J =9.2 Hz, 1H), 7.88 (d, J =5.0 Hz, 1H), 7.41 (d, J =9.5 Hz, 1H), 7.19 (d, J =5.0 Hz, 1H), 4.50 (dd, J = 49.3, 9.2 Hz, 1H), 4.28 (s, 1H), 4.08-3.89 (m, 1H), 3.71 (s, 4H), 3.64-3.38 (m, 3H), 3.17 (dd, J = 15.0, 7.5 Hz, 1H), 2.35-2.07 (m, 5H), 1.33 (d, J = 1.6 Hz, 6H). compound 1H-NMR
880 1 H NMR (400 MHz, Methanol-d4) δ 8.75 - 8.67 (m, 2H), 8.59 (d, J = 2.1 Hz, 1 H),
8.21 (d, J = 2.6 Hz, 1 H), 7.97 (s, 1 H), 7.84 (d, J = 5.1 Hz, 1 H), 7.76 (dd, J = 9.3, 2.6 Hz, 1H), 7.18 (dd, J =9.0, 7.1
Hz, 2H), 4.60 - 4.41 (m, 1 H), 4.36 (d, J = 13.3 Hz, 2H), 4.11 - 3.87 (m, 2H), 3.68 - 3.46 (m, 1H), 3.19 (t, J = 13.0 Hz, 2H), 2.12 -1.99 (m, 2H), 1.98 (s, 3H), 1.58 (q, J = 11.4, 10.7 Hz, 2H), 1.33 (
d, J = 1.7 Hz, 6H).
881 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 2H), 8.62 (d, J = 2.1 Hz,
1 H), 8.20 (d, J = 2.6 Hz, 1 H), 7.96 (s, 1 H), 7.92 - 7.78 (m, 2H), 7.27 (d, J = 9.4 Hz, 1H), 7.19 (d, J =5.1 Hz, 1H), 4.68-4.38 (m, 1H), 4.32 (d, J = 13.5 Hz, 2H), 4.11 - 3.91 (m, 1 H), 3.84 - 3.70 (m, OH), 3.68 (s, 3H), 3.63 - 3.44 (m, 1 H), 3.27 (t, J = 12.8 Hz, 3H), 2.08 (d, J = 12.9 Hz, 2H), 1.61 (d, J = 11.8 Hz, 2H), 1.33 (d, J = 1.6 Hz, 6H).
882 1 H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.68 (m, 2H), 8.62 (d, J = 2.1 Hz, 1 H),
8.18 (s, 1H), 8.14 (s, 1H), 7.89 (d, J =5.1 Hz, 1H), 7.86 (s, 1H), 7.20 (d, J =5.0 Hz, 1H), 5.68-5.39 (m, 2H), 4.61 -4.36 (m, 1H), 4.14-3.99 (m, 3H), 3.99-3.73 (m, 2H), 3.56 (td, J = 15.6, 9.4 Hz, 1H), 1.32 (d, J = 1.7 Hz, 6H).
883 1 H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.69 (m, 2H), 8.56 (d, J = 2.1 Hz, 1 H),
8.19 (s, 1H), 8.16 (s, 1H), 7.86 (d, J =6.1 Hz, 2H), 7.20 (d, J =5.1 Hz, 1H), 5.66 (dq, J = 52.4, 3.6 Hz, 1 H), 5.55 - 5.37 (m, 1 H), 4.49 (ddd, J = 49.0, 9.4, 2.1 Hz, 1H), 4.19 (dd, J = 12.4, 8.1 Hz, 1H), 4.09-3.91 (m, 2H), 3.91 -3.72 (m, 2H), 3.56 (td, J = 15.4, 9.3 Hz, 1H), 1.41 - 1.24 (m, 6H).
884 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.75 (d, J = 2.2 Hz, 1 H), 8.61 (d,
J =2.1 Hz, 1H), 8.15 (d, J =2.5 Hz, 1H), 7.99 (d, J = 9.7 Hz, 2H), 7.89 (d, J =5.1 Hz, 1 H), 7.28 (d, J = 9.6 Hz, 1 H), 7.19 (d, J = 5.1 Hz, 1 H), 4.60 - 4.37 (m, 2H), 4.08 - 3.90 (m, 1 H), 3.78 (t, J = 9.1 Hz, 1 H), 3.69 - 3.46 (m, 4H), 3.42 (s, 3H), 2.21 (ddd, J = 38.8, 23.0, 8.4 Hz, 4H), 1.33 (d, J = 1.7 Hz, 6H).
885 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (s, 1 H), 8.74 (d, J = 2.2 Hz, 1 H), 8.62 (d,
J =2.1 Hz, 1H), 8.13 (d, J =2.5 Hz, 1H), 7.99 (d, J = 6.1 Hz, 2H), 7.89 (d, J =5.1 Hz, 1 H), 7.22 - 7.11 (m, 2H), 4.49 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.00 (ddd, J = 36.5, 14.6, 2.1 Hz, 1H), 3.89-3.74 (m, 2H), 3.74-3.63 (m, 1H), 3.58 (tt, J =8.8, 4.8 Hz, 2H), 3.49 (dt, J = 10.6, 7.2 Hz, 2H), 3.42 (s, 3H), 2.81 (p, J = 7.1 Hz, 1 H), 2.42-2.20 (m, 1H), 2.12- 1.93 (m, 1H), 1.33 (d, J = 1.7 Hz, 6H).
886 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.1 Hz, 1 H), 8.71 (s, 1 H), 8.59 (d,
J = 2.1 Hz, 1 H), 8.25 (s, 1 H), 7.94 (s, 1 H), 7.82 (d, J = 5.1 Hz, 1 H), 7.75 (dd, J = 9.2, 2.7 Hz, 1H), 7.18 (d, J = 5.1 Hz, 1H), 7.10 (d, J = 9.2 Hz, 1H), 4.50 (dd, J = 49.0, 9.2 Hz, 1H), 4.24 (d, J = 12.7 Hz, 1H), 4.16-3.87 (m, 3H), 3.78-3.61 (m, 2H), 3.61 -3.39 (m, 2H), 3.21 -2.97 (m, 1H), 2.81 (dd, J = 12.8, 10.5 Hz, 1H), 2.01 (s, 3H), 1.33 (s, 6H).
887 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (d, J = 2.2 Hz, 1 H), 8.70 (s, 1 H), 8.59 (d,
J = 2.1 Hz, 1 H), 8.25 (d, J = 2.6 Hz, 1 H), 7.94 (s, 1 H), 7.81 (d, J = 5.1 Hz, 1 H), 7.72 (dd, J =9.0, 2.7 Hz, 1H), 7.18 (d, J =5.1 Hz, 1H), 7.06 (d, J =9.1 Hz, 1H), 4.49 (dd, J =49.0, 9.2 Hz, 1H), 4.25 (d, J = 12.7 Hz, 1H), 4.17-3.87 (m, 3H), 3.70 (d, J = 16.5 Hz, 5H), 3.55 (td, J = 14.8, 14.2, 8.7 Hz, 1H), 3.18 - 2.95 (m, 1 H), 2.78 (t, J = 11.6 Hz, 1 H), 1.33 (s, 6H).
888 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (s, 1 H), 8.58 (d, J = 2.1 Hz, 1 H), 8.40 (s,
1H), 8.13 (d, J =8.8 Hz, 1H), 8.07 (s, 1H), 7.91 (d, J =9.0 Hz, 1H), 7.84 (d, J =5.1 Hz, 1H), 7.19 (d, J = 5.1 Hz, 1H), 4.50 (dd, J =48.9, 9.3 Hz, 1H), 4.12-3.89 (m, 1H), 3.83 (d, J = 10.7 Hz, 2H), 3.61 -3.43 (m, 1H), 1.32 (d, J = 9.6 Hz, 6H).
889 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.3 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.09 (d, J = 5.1 Hz, 1 H), 7.91 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.72 (s, 1H), 4.47 (dd, J =49.2, 9.3 Hz, 1H), 4.18 (t, J =7.9 Hz, 2H), 4.05 (dd, J = 14.5, 4.9 Hz, 2H), 4.00-3.72 (m, 1H), 3.54 (dd, J = 15.5, 9.7 Hz, 1H), 2.54 (dd, J = 11.7, 7.4 Hz, 1H), 2.27 (q, J = 10.6, 8.9 Hz, 1H), 1.86 (s, 3H), 1.32 (d, J = 1.7 Hz, 6H).
890 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.06 (s, 1 H), 7.90 (s, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 4.68 (s, 1 H), 4.56-4.31 (m, 1H), 4.16-3.73 (m, 5H), 3.64 (s, 3H), 3.59-3.44 (m, 1H), 2.49 (s, 1 H), 2.24 (s, 1 H), 1.32 (d, J = 1.7 Hz, 6H).
891 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.03 (d, J = 5.0 Hz, 1 H), 7.87 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.56 - 4.28 (m, 1 H), 4.09 - 3.80 (m, 2H), 3.70 - 3.57 (m, 3H), 3.57 - 3.36 (m, 1 H), 3.27 - 3.03 (m, 1 H), 2.22 (q, J = 7.9 Hz, 2H), 1.32 (d, J = 1.8 Hz, 6H).
892 1 H NMR (400 MHz, Methanol-d4) δ 9.02 (s, OH), 8.78 (d, J = 2.3 Hz, 1 H), 8.70 (d,
J = 2.1 Hz, 1 H), 8.56 (s, 1 H), 8.09 (d, J = 5.1 Hz, 1 H), 7.90 (s, 1 H), 7.24 (d, J = 4.9 Hz, 1H), 4.73 (d, J = 8.3 Hz, 1H), 4.49 (dd, J =48.7, 9.6 Hz, 1H), 4.17 (t, J =7.9 Hz, 2H), 4.05 (dd, J = 14.2, 4.7 Hz, 1H), 4.00-3.72 (m, 1H), 3.62-3.42 (m, 1H), 2.54 (t, J = 9.6 Hz, 1 H), 2.27 (d, J = 9.2 Hz, 1 H), 1.85 (s, 3H), 1.32 (s, 6H).
893 1 H NMR (400 MHz, Methanol-d4) δ 9.03 (s, OH), 8.78 (d, J = 2.2 Hz, 1 H), 8.69 (d, compound 1 H-NMR
J = 2.2 Hz, 1 H), 8.59 (s, 1 H), 8.05 (d, J = 5.0 Hz, 1 H), 7.89 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.68 (s, 1 H), 4.61 - 4.33 (m, 1 H), 4.14 - 3.74 (m, 4H), 3.63 (s, 3H), 3.54 (dt, J = 15.6, 8.0 Hz, 1 H), 2.49 (s, 1 H), 2.24 (s, 1 H), 1.32 (s, 6H).
894 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.2 Hz, 1 H), 8.68 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.03 (d, J = 5.0 Hz, 1 H), 7.87 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.47 (ddd, J = 49.1 , 9.3, 2.2 Hz, 1 H), 4.08 - 3.84 (m, 2H), 3.68 (d, J = 4.0 Hz, 2H), 3.63 (dt, J = 6.9, 3.4 Hz, 1 H), 3.53 (td, J = 15.3, 9.3 Hz, 1 H), 3.28 - 3.02 (m, 1 H), 2.23 (dd, J = 10.1 , 6.5 Hz, 2H), 1 .32 (d, J = 1.8 Hz, 6H).
895 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.71 (d, J = 2.2 Hz,
1 H), 8.63 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.76 (s, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 4.61 - 4.45 (m, OH), 4.45 - 4.20 (m, 3H), 4.14 (s, 2H), 4.02 - 3.79 (m, 1 H), 3.53 (td, J = 15.2, 9.4 Hz, 1 H), 3.07 - 2.93 (m, 2H), 2.61 - 2.41 (m, 2H), 1.32 (d, J = 1.8 Hz, 6H).
896 1 H NMR (400 MHz, Methanol-d4) δ 8.83 - 8.70 (m, 2H), 8.59 (d, J = 2.2 Hz, 1 H),
8.21 (s, 1 H), 8.08 (s, 1 H), 7.88 (d, J = 5.0 Hz, 1 H), 7.84 (s, 1 H), 7.20 (d, J = 5.0 Hz, 1 H), 5.44 - 5.28 (m, 1 H), 3.99 - 3.83 (m, 1 H), 3.75 (ddd, J = 17.2, 11.8, 7.6 Hz, 2H), 3.58 (td, J = 1 1.1 , 10.5, 4.4 Hz, 1 H), 2.64 (dq, J = 16.1 , 8.6 Hz, 1 H), 2.55 - 2.39 (m, OH).
897 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.73 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.51 (dd, J = 9.0, 2.0 Hz, 1 H), 4.46 - 4.28 (m, 1 H), 4.18 (s, 2H), 4.12 - 3.86 (m, 3H), 3.68 (s, 3H), 3.52 (dt, J = 15.3, 7.6 Hz, 1 H), 2.95 - 2.80 (m, 2H), 2.40 (dd, J = 1 1.8, 9.0 Hz, 2H), 1.32 (d, J = 1.7 Hz, 6H).
898 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.62 (s, 1 H), 8.01 (d, J = 5.1 Hz, 1 H), 7.74 (s, 1 H), 7.25 (d, J = 5.0 Hz, 1 H), 4.56 - 4.29 (m, 2H), 4.22 (s, 2H), 4.07 (s, 2H), 3.85 (q, J = 9.9, 9.2 Hz, 2H), 3.68 - 3.44 (m, 1 H), 2.99 (dd, J = 11.8, 8.6 Hz, 2H), 2.47 (t, J = 10.4 Hz, 2H), 1.32 (d, J = 1 .8 Hz, 6H).
899 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.64 (s, 1 H), 8.07 (d, J = 5.0 Hz, 1 H), 7.91 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.46 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 3.95 (ddd, J = 36.3, 14.5, 2.2 Hz, 1 H), 3.73 (d, J = 7.3 Hz, 2H), 3.70 - 3.45 (m, 3H), 3.40 (d, J = 8.2 Hz, OH), 3.15 (dd, J = 11 .8, 8.5 Hz, 1 H), 2.90 (p, J = 7.7 Hz, 1 H), 2.36 (dt, J = 12.7, 6.8 Hz, 1 H), 1 .94 (dt, J = 13.2, 8.4 Hz, 1 H), 1.32 (d, J = 1.7 Hz, 6H).
900 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.04 (d, J = 5.0 Hz, 1 H), 7.89 (s, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 4.46 (dd, J = 49.0, 9.2 Hz, 1 H), 3.97 (dd, J = 36.2, 14.5 Hz, 1 H), 3.66 (t, J = 9.5 Hz, 6H), 3.58 - 3.40 (m, 1 H), 3.27 (s, 1 H), 2.73 (d, J = 9.8 Hz, 1 H), 2.21 (s, 1 H), 2.00 - 1 .79 (m, 1 H), 1.38 - 1.28 (m, 6H).
901 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.05 (d, J = 5.0 Hz, 1 H), 7.86 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.45 (dd, J = 49.1 , 9.2 Hz, 1 H), 4.1 1 - 3.80 (m, 1 H), 3.64 (t, J = 6.4 Hz, 2H), 3.52 (td, J = 14.3, 12.5, 7.0 Hz, 3H), 3.16 (t, J = 8.9 Hz, 2H), 3.00 (q, J = 8.3 Hz, 1 H), 2.94 - 2.85 (m, 1 H), 2.80 (q, J = 7.4 Hz, 1 H), 2.26 (q, J = 5.6 Hz, 1 H), 1 .80 (dq, J = 14.0, 7.3 Hz, 1 H), 1.32 (d, J = 1.8 Hz, 6H).
902 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.71 (d, J = 2.1 Hz,
1 H), 8.64 (s, 1 H), 8.05 (dd, J = 7.6, 5.1 Hz, 1 H), 7.77 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.46 (ddd, J = 34.2, 17.2, 9.1 Hz, 2H), 3.95 (dd, J = 36.3, 14.6 Hz, 1 H), 3.65 - 3.51 (m, 1 H), 3.42 (t, J = 7.2 Hz, 1 H), 2.96 - 2.81 (m, 1 H), 2.76 (ddd, J = 10.4, 7.6, 2.9 Hz, 1 H), 2.34 (dq, J = 23.1 , 7.8, 7.2 Hz, 3H), 2.19 (t, J
= 7.5 Hz, 1 H), 1.32 (s, 6H).
903 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.71 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.04 (d, J = 5.0 Hz, 1 H), 7.81 - 7.68 (m, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.59 - 4.33 (m, 2H), 3.97 (dd, J = 36.4, 14.6 Hz, 1 H), 3.81 - 3.66 (m, 3H), 3.65 - 3.46 (m, 3H), 3.42 (d, J = 6.5 Hz, 2H), 2.71 (dt, J = 20.0, 10.0 Hz, 2H), 2.38 - 2.07 (m, 3H), 2.03 (t, J = 7.4 Hz, 1 H), 1.32 (d, J = 1.7 Hz, 6H).
904 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.74 - 8.66 (m, 1 H),
8.61 (s, 1 H), 8.03 (t, J = 4.9 Hz, 1 H), 7.75 (d, J = 10.1 Hz, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.57 - 4.27 (m, 1 H), 3.96 (dd, J = 36.4, 14.6 Hz, 1 H), 3.80 - 3.42 (m, 3H), 3.26 (d, J = 11.5 Hz, 3H), 3.10 (t, J = 7.2 Hz, 1 H), 2.79 (dt, J = 27.4, 9.7 Hz, 2H), 2.30 (dq, J = 18.1 , 10.2 Hz, 3H), 2.13 (t, J = 7.3 Hz, 1 H), 1.32 (d, J = 1.7 Hz, 6H).
905 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.70 (s, 1 H), 8.63 (s,
1 H), 8.07 (d, J = 5.0 Hz, 1 H), 7.88 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.61 - 4.33 (m, 1 H), 4.26 (t, J = 9.9 Hz, 2H), 4.15 - 3.99 (m, 2H), 3.90 (d, J = 7.3 Hz, 3H), 3.65 - 3.37 (m, 2H), 1.32 (s, 6H).
906 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.06 (d, J = 5.0 Hz, 1 H), 7.89 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.58 - 4.28 (m, 1 H), 4.20 (t, J = 8.6 Hz, 2H), 4.05 - 3.92 (m, 1 H), 3.85 (d, J = 7.1 Hz, 2H), 3.69 (s, 3H), 3.51 (td, J = 15.5, 9.3 Hz, 1 H), 3.19 - 3.01 (m, 1 H), 1.32 (s, compound 1H-NMR
6H).
907 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.61 (s, 1 H), 8.07 (d, J = 5.0 Hz, 1 H), 7.87 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.46 (ddd, J =49.1, 9.3, 2.1 Hz, 1H), 4.10 (t, J = 8.7 Hz, 2H), 4.04-3.88 (m, 2H), 3.76 (q, J = 9.3 Hz, 2H), 3.54 (td, J = 15.4, 9.3 Hz, 1H), 3.29-3.11 (m, 1H), 1.31 (d, J = 1.7 Hz, 6H).
908 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.1 Hz,
1 H), 8.66 (s, 1 H), 8.06 (d, J = 5.0 Hz, 1 H), 7.78 (s, 1 H), 7.25 (d, J = 5.0 Hz, 1 H), 4.56-4.25 (m, 2H), 4.08-3.82 (m, 3H), 3.54 (td, J = 15.3, 9.3 Hz, 1H), 3.19 (ddd, J = 10.6, 7.4, 3.4 Hz, 2H), 2.85 (t, J = 8.3 Hz, 2H), 2.82 - 2.72 (m, 2H), 1.32 (d, J = 1.8 Hz, 6H).
909 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.03 (d, J = 5.1 Hz, 1 H), 7.75 (s, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 4.47 (dd, J =48.9, 9.3 Hz, 1H), 4.18 (t, J = 7.8 Hz, 1H), 3.98 (dd, J =37.3, 15.2 Hz, 3H), 3.73 (d, J = 36.6 Hz, 2H), 3.52 (d, J = 13.8 Hz, 1 H), 2.95 (s, 3H), 2.53 (t, J = 7.4 Hz, 2H), 1.32 (s, 6H).
910 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.1 Hz,
1 H), 8.59 (s, 1 H), 8.04 (d, J = 5.0 Hz, 1 H), 7.76 (s, 1 H), 7.25 (d, J = 5.0 Hz, 1 H), 4.45 (dd, J =49.1, 9.2 Hz, 1H), 4.21 -4.08 (m, 1H), 3.97 (dd, J = 36.4, 14.7 Hz, 1 H), 3.51 (t, J = 7.2 Hz, 2H), 2.85 (t, J = 9.1 Hz, 2H), 2.48 (t, J = 7.1 Hz, 2H), 2.41 (t, J = 10.3 Hz, 2H), 1.32 (s, 6H).
911 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.71 (d, J = 2.1 Hz,
1 H), 8.66 (s, 1 H), 8.04 (d, J = 5.0 Hz, 1 H), 7.77 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.64-4.33 (m, 2H), 4.09-3.85 (m, 3H), 3.54 (td, J = 15.3, 9.3 Hz, 1H), 2.81 -2.59 (m, 4H), 1.32 (s, 6H).
912 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.72 (s, 1 H), 8.61 (s,
1 H), 8.03 (s, 1 H), 7.81 (s, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 4.67 (s, 1 H), 4.58 - 4.32 (m, 1 H), 4.09 - 3.80 (m, 4H), 3.75 (s, 3H), 3.52 (td, J = 15.3, 9.5 Hz, 1 H), 2.55 - 2.30 (m, 4H), 1.32 (d, J = 1.7 Hz, 6H).
913 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.71 (d, J = 2.2 Hz,
1 H), 8.64 (s, 1 H), 8.01 (d, J = 5.0 Hz, 1 H), 7.68 (s, 1 H), 7.25 (d, J = 5.0 Hz, 1 H), 4.63 - 4.34 (m, 1 H), 4.34 - 4.21 (m, 1 H), 3.96 (dd, J = 36.3, 14.6 Hz, 1 H), 3.68 - 3.42 (m, 4H), 3.17-3.01 (m, 2H), 2.49 (t, J =7.3 Hz, 2H), 2.45-2.36 (m, 2H), 1.32 (d, J = 1.7 Hz, 6H).
914 1H NMR (400 MHz, Methanol-d4) δ 8.57 (d, J = 2.2 Hz, 1H), 8.19 (s, 1H), 8.15 (s,
1 H), 7.86 (d, J = 4.3 Hz, 2H), 7.21 (d, J = 5.0 Hz, 1 H), 5.66 (dd, J = 52.5, 3.8 Hz, 1H), 5.54-5.34 (m, 1H), 4.64-4.35 (m, 1H), 4.19 (dd, J = 12.3, 8.2 Hz, 1H), 4.04 (dd, J = 12.2, 3.5 Hz, 1 H), 4.01 - 3.92 (m, 1 H), 3.88 (d, J = 3.3 Hz, 1 H), 3.82 (d, J = 3.9 Hz, 1 H), 3.56 (td, J = 15.4, 9.5 Hz, 1 H), 1.33 (d, J = 1.7 Hz, 6H).
915 1 H NMR (400 MHz, Methanol-d4) δ 8.79 - 8.68 (m, 2H), 8.57 (d, J = 2.2 Hz, 1 H),
8.14 (d, J = 2.5 Hz, 1H), 8.01 (s, 1H), 7.86 (d, J =5.5 Hz, 2H), 7.18 (d, J =5.0 Hz, 1 H), 7.07 (d, J = 9.3 Hz, 1 H), 4.73 (s, 1 H), 4.61 - 4.38 (m, 1 H), 4.31 - 4.20 (m, 1 H), 4.20-4.12 (m, 1H), 4.00 (dd, J = 36.3, 14.6 Hz, 1 H), 3.81 (d, J =6.1 Hz, 2H), 3.68 - 3.53 (m, 1 H), 3.50 (s, 3H), 2.60 (s, 1 H), 2.38 (d, J = 9.8
Hz, 1H), 1.33 (d, J = 1.7 Hz, 6H).
916 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.0 Hz,
1H), 8.67 (s, 1H), 8.12 (d, J = 5.0 Hz, 1H), 7.92 (s, 1H), 7.24 (d, J =5.0 Hz, 1H), 4.47 (dd, J =49.1, 9.0 Hz, 1H), 4.20 (dd, J = 12.3, 2.5 Hz, 1H), 4.13-3.63 (m, 7H), 3.63-3.39 (m, 2H), 1.32 (s, 5H).
917 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.72 - 8.56 (m, 2H),
8.10 (d, J = 5.1 Hz, 1H), 7.93 (s, 1H), 7.24 (d, J =5.0 Hz, 1H), 4.62-4.35 (m, 1H), 4.21 (d, J = 12.0 Hz, 1H), 4.08- 3.69 (m, 7H), 3.69 - 3.37 (m, 2H), 1.32 (s, 6H).
918 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.1 Hz,
1 H), 8.58 (s, 1 H), 8.08 (t, J = 56.8 Hz, 2H), 7.25 (d, J = 5.0 Hz, 1 H), 4.63 - 4.27 (m, 2H), 4.10-3.62 (m, 7H), 3.52 (dd, J = 13.6, 5.7 Hz, 2H), 1.31 (s, 6H).
919 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1H), 8.58 (s, 1H), 8.15 (d, J = 53.9 Hz, 2H), 7.25 (d, J =5.0 Hz, 1H), 4.58-4.22 (m, 2H), 4.15 - 3.66 (m, 8H), 3.66 - 3.43 (m, 2H), 1.31 (s, 6H).
920 1 H NMR (400 MHz, Methanol-d4) δ 8.82 - 8.65 (m, 2H), 8.58 (d, J = 2.1 Hz, 1 H),
8.47 (s, 2H), 7.87 (d, J =3.9 Hz, 2H), 7.18 (d, J =5.0 Hz, 1H), 6.01 (s, 1H), 4.71 - 4.38 (m, 1 H), 4.32 (s, 2H), 4.28 - 4.02 (m, 1 H), 4.02 - 3.81 (m, 1 H), 3.55 (dd, J = 24.4, 14.4 Hz, 1H), 1.33 (s, 6H).
921 1 H NMR (400 MHz, Methanol-d4) δ 8.86 - 8.70 (m, 2H), 8.56 (d, J = 2.8 Hz, 3H),
7.97-7.83 (m, 2H), 7.18 (d, J = 5.0 Hz, 1H), 4.49 (ddd, J =49.1, 9.4, 2.1 Hz, 1H), 4.20 (t, J =5.2 Hz, 4H), 4.09-3.91 (m, 1H), 3.57 (td, J = 15.4, 9.4 Hz, 1H), 3.38 (t, J = 5.3 Hz, 4H), 1.37 - 1.26 (m, 6H). compound 1 H-NMR
922 1 H NMR (400 MHz, Methanol-d4) δ 8.74 (s, 2H), 8.61 (d, J = 2.2 Hz, 1 H), 8.26 (d,
J = 2.6 Hz, 1 H), 7.94 - 7.78 (m, 2H), 7.18 (d, J = 5.0 Hz, 1 H), 7.1 1 (d, J = 9.4 Hz, 1 H), 4.60 - 4.36 (m, 1 H), 4.16 - 3.92 (m, 1 H), 3.86 (q, J = 12.2 Hz, 4H), 3.57 (td, J = 15.4, 9.4 Hz, 1 H), 3.37 (d, J = 7.5 Hz, 1 H), 2.06 (d, J = 9.1 Hz, 1 H), 1 .33 (s, 6H).
923 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.1 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.29 (s, 1 H), 7.92 (d, J = 5.0 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.33 (t, J = 7.7 Hz, 2H), 4.08 (t, J = 7.8 Hz, 2H), 3.97 (s, 2H), 2.39 (p, J = 7.8 Hz, 2H), 2.24 (t, J = 8.0 Hz, 6H), 1.96 - 1.85 (m, 6H).
924 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.51 (s, 1 H), 8.25 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 3.45 - 3.31 (m, 2H), 2.24 (dd, J = 10.3, 5.7 Hz, 6H), 1.90 (dd, J = 10.3, 5.7 Hz, 6H), 1 .15 (s, 3H), 1 .09 (s, 3H), 0.98 - 0.88 (m, 1 H), 0.53 (dd, J = 8.6, 4.4 Hz, 1 H), 0.20 (t, J = 4.9 Hz, 1 H).
925 1 H NMR (400 MHz, Methanol-d4) δ 8.88 (s, 1 H), 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d,
J = 2.2 Hz, 1 H), 8.60 (s, 1 H), 8.33 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.58 (d, J = 1 .5 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.68 (s, 2H), 3.97 (s, 3H), 2.28 - 2.19 (m, 6H), 1 .95 - 1.86 (m, 6H).
926 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.47 (s, 1 H), 8.26 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.61 (s, 1 H), 7.48 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.40 (s, 2H), 3.86 (s, 3H), 2.32 - 2.19 (m, 6H), 1.98 - 1.83 (m, 6H).
927 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (dd, J = 15.4, 2.2 Hz, 2H), 8.56 (s, 1 H),
7.99 (d, J = 5.1 Hz, 1 H), 7.80 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 5.48 (s, 1 H), 4.53 - 4.32 (m, 2H), 3.94 (dd, J = 36.5,
14.5 Hz, 1 H), 3.55 - 3.45 (m, 1 H), 3.42 (d, J = 7.6 Hz, 2H), 3.13 (p, J = 8.7 Hz, 1 H), 2.54 (s, 1 H), 2.44 (dd, J = 11 .6, 6.6 Hz, 2H), 2.33 - 2.21 (m, 3H), 2.15 (q, J = 8.9 Hz, 1 H), 2.01 (dt, J = 18.6,
9.1 Hz, 1 H), 1.88 (t, J = 10.0 Hz, 1 H), 1.29 (d, J = 1.7 Hz, 6H).
928 1 H NMR (400 MHz, Methanol-d4) δ 8.70 - 8.64 (m, 2H), 8.65 (s, 1 H), 8.61 (d, J =
1 .8 Hz, 1 H), 8.45 (s, 1 H), 7.88 (d, J = 4.9 Hz, 1 H), 7.46 (s, 1 H), 7.39 (s, 1 H), 7.15 (d, J = 5.0 Hz, 1 H), 4.78 (s, 2H), 3.93 (s, 3H), 2.20 (t, J = 7.9 Hz, 6H), 1 .88 (t, J = 8.0 Hz, 6H).
929 1 H NMR (400 MHz, Methanol-d4) δ 8.70 (dd, J = 24.6, 2.2 Hz, 2H), 8.59 (s, 1 H),
8.57 (s, 1 H), 8.35 (s, 1 H), 7.91 (d, J = 5.0 Hz, 1 H), 7.45 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.56 (s, 2H), 3.88 (s, 3H), 2.24 (t, J = 7.9 Hz, 6H), 1.90 (t, J = 8.0 Hz, 6H).
930 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.69 (s, 1 H), 8.65 (ddd, J = 5.4, 1.8, 0.9 Hz, 1 H), 8.33 (s, 1 H), 8.17 (td, J = 7.8, 1.7 Hz, 1 H), 7.94 (d, J = 5.1 Hz, 1 H), 7.75 (d, J = 8.0 Hz, 1 H), 7.63 (dd, J = 7.6, 5.7 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.78 (s, 2H), 2.23 (dd, J = 10.0, 6.1 Hz, 6H), 1.95 - 1.84 (m, 6H).
931 1 H NMR (400 MHz, Methanol-d4) δ 8.82 (s, 1 H), 8.76 (d, J = 2.2 Hz, 1 H), 8.73 - 8.68 (m, 2H), 8.64 (d, J = 1.3 Hz, 1 H), 8.42 (d, J = 8.2 Hz, 1 H), 8.33 (s, 1 H), 7.94 (d, J = 5.1 Hz, 1 H), 7.92 - 7.84 (m, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.71 (s, 2H), 2.28 - 2.17 (m, 6H), 1.97 - 1.83 (m, 6H).
932 1 H NMR (400 MHz, Methanol-d4) δ 8.77 (d, J = 2.1 Hz, 1 H), 8.74 - 8.68 (m, 4H),
8.34 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.89 (d, J = 5.9 Hz, 2H), 7.23 (d, J = 5.0 Hz, 1 H), 4.78 (s, 2H), 2.30 - 2.17 (m, 6H), 1 .95 - 1 .83 (m, 6H).
933 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 5.0 Hz, 2H), 8.76 (d, J = 2.2 Hz,
1 H), 8.71 (d, J = 2.2 Hz, 1 H), 8.68 (s, 1 H), 8.30 (s, 1 H), 7.94 (d, J = 5.0 Hz, 1 H), 7.42 (t, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.0 Hz, 1 H), 4.78 (s, 2H), 2.29 - 2.17 (m, 6H), 1 .94 - 1.83 (m, 6H).
934 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.54 (s, 1 H), 8.30 (s, 1 H), 7.93 (d, J = 5.0 Hz, 1 H), 7.40 (d, J = 2.0 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 6.31 (d, J = 1.9 Hz, 1 H), 4.63 (s, 2H), 3.91 (s, 3H), 2.24 (dd, J = 10.4, 5.6 Hz, 6H), 1.97 - 1.84 (m, 6H).
935 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.55 (s, 1 H), 8.29 (s, 1 H), 7.92 (d, J = 5.0 Hz, 1 H), 7.53 (d, J = 2.2 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 6.26 (d, J = 2.3 Hz, 1 H), 4.52 (s, 2H), 3.86 (s, 3H), 2.25 (dd, J = 10.4, 5.6 Hz, 6H), 1.90 (dd, J = 10.1 , 5.8 Hz, 6H).
936 1 H NMR (400 MHz, Methanol-d4) δ 9.16 (s, 1 H), 8.74 (s, 1 H), 8.61 (d, J = 2.2 Hz,
1 H), 8.59 (s, 1 H), 8.58 (d, J = 2.2 Hz, 1 H), 8.30 (d, J = 1.5 Hz, 1 H), 8.24 (s, 1 H), 8.07 (s, 1 H), 7.99 (d, J = 4.8 Hz, 1 H), 7.12 (d, J = 4.9 Hz, 1 H), 4.45 (dd, J = 48.9,
7.5 Hz, 1 H), 3.93 (ddd, J = 36.9, 15.3, 1.9 Hz, 1 H), 3.51 - 3.44 (m, 1 H), 1.26 (d, J =
1 .6 Hz, 6H).
937 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.75 (d, J = 2.2 Hz,
1 H), 8.56 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.81 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.54 - 4.31 (m, 2H), 3.94 (dd, J = 36.1 , 14.2 Hz, 1 H), 3.55 - 3.44 (m, 1 H), 3.42 (d, J = 7.5 Hz, 2H), 2.56 (s, 1 H), 2.44 (s, 2H), 2.25 (q, J = 9.5 Hz, 2H), 2.07 (s, 6H), 1.29 compound 1 H-NMR
(d, J = 1.6 Hz, 7H).
938 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.2 Hz, 1 H), 8.75 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.79 (s, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.53 - 4.33 (m, 2H), 4.05 - 3.83 (m, 1 H), 3.55 - 3.45 (m, 1 H), 3.43 (d, J = 7.6 Hz, 2H), 2.56 (s, 1 H), 2.51 - 2.39 (m, 1 H), 2.27 (q, J = 9.6 Hz, 2H), 1.29 (d, J = 1.6 Hz, 7H), 1.14 (d, J = 6.9 Hz, 7H).
939 1 H NMR (400 MHz, Methanol-d4) δ 9.16 (s, 1 H), 8.78 (s, 1 H), 8.62 (d, J = 2.3 Hz,
1 H), 8.59 (s, 1 H), 8.55 (d, J = 2.3 Hz, 1 H), 8.28 (d, J = 9.8 Hz, 1 H), 8.20 (s, 2H), 8.00 (d, J = 4.9 Hz, 1 H), 7.15 - 7.06 (m, 2H), 4.44 (dd, J = 48.8, 8.7 Hz, 1 H), 3.87 (dd, J = 36.6, 14.7 Hz, 1 H), 3.59 - 3.44 (m, 1 H), 1.26 (s, 6H).
940 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 1 .7 Hz, 2H), 8.57 (s, 1 H), 8.20 (s,
1 H), 7.99 (d, J = 5.1 Hz, 1 H), 7.77 (s, 1 H), 7.21 (d, J = 5.0 Hz, 1 H), 4.52 - 4.31 (m, 2H), 3.94 (dd, J = 36.4, 14.5 Hz, 1 H), 3.55 - 3.42 (m, 3H), 3.00 - 2.87 (m, 1 H), 2.87 - 2.66 (m, 2H), 2.55 (dd, J = 15.7, 7.9 Hz, 2H), 2.44 (q, J = 7.9, 5.9 Hz, 2H), 2.34 - 2.20 (m, 3H), 1.29 (d, J = 1.6 Hz, 6H).
941 1 H NMR (400 MHz, Methanol-d4) δ 8.99 (s, OH), 8.78 - 8.71 (m, 2H), 8.56 (s, 1 H),
7.96 (d, J = 5.1 Hz, 1 H), 7.83 (s, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 4.68 (td, J = 6.3, 3.6 Hz, 1 H), 4.52 - 4.33 (m, 2H),
3.94 (dd, J = 35.8, 14.2 Hz, 1 H), 3.66 - 3.37 (m, 3H), 2.57 (s, 1 H), 2.53 - 2.41 (m, 2H), 2.27 (dq, J = 19.3, 9.5, 8.9 Hz, 2H), 1.89 - 1.65 (m, 2H), 1 .29 (d, J = 1.6 Hz, 6H), 1.10 (ddt, J = 12.7, 9.2,
6.5 Hz, 1 H).
942 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.63 (s, 1 H), 8.30 (s, 1 H), 7.92 (d, J = 5.0 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.72 (q, J = 11.2, 10.7 Hz, 1 H), 4.52 (q, J = 7.1 Hz, 1 H), 4.50 - 4.27 (m, 2H), 2.24 (t, J = 8.0 Hz, 6H), 1.95 - 1.85 (m, 6H), 1.45 (d, J = 7.1 Hz, 3H).
943 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.2 Hz,
1 H), 8.63 (s, 1 H), 8.29 (s, 1 H), 7.92 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.98 (q, J = 7.0 Hz, 1 H), 3.82 - 3.53 (m, 8H), 2.28 - 2.19 (m, 6H), 1 .90 (t, J = 8.0 Hz, 6H), 1 .43 (d, J = 7.1 Hz, 3H).
944 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1 H), 8.73 (d, J = 2.1 Hz,
1 H), 8.62 (s, 1 H), 8.32 (s, 1 H), 8.00 (s, OH), 7.96 (d, J = 5.0 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 4.51 (d, J = 33.8 Hz,
1 H), 4.32 - 4.13 (m, 1 H), 4.18 (s, 1 H), 3.72 (dd, J = 9.0, 4.8 Hz, 2H), 3.68 - 3.58 (m, OH), 3.57 - 3.47 (m, 2H), 3.02 (s, 1 H), 2.88 (s, 1 H), 2.32 - 2.23 (m, 6H), 2.19 - 1 .97 (m, 1 H), 1.93 (t, J = 8.0
Hz, 6H).
945 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1 H), 8.73 (d, J = 2.1 Hz,
1 H), 8.54 (s, 1 H), 8.31 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 5.19 - 5.01 (m, 1 H), 4.04 - 3.90 (m, 1 H), 3.77 (ddd, J = 21.8, 14.7, 7.1 Hz, 1 H), 2.83 (d, J = 4.4 Hz, 3H), 2.28 (t, J = 8.0 Hz, 6H), 1.93 (t, J = 8.0 Hz, 6H).
946 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.1 Hz,
1 H), 8.55 (s, 1 H), 8.32 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.0 Hz, 1 H), 5.69 - 5.51 (m, 1 H), 3.94 - 3.73 (m, 2H), 3.20 (s, 3H), 3.00 (s, 3H), 2.28 (t, J = 7.9 Hz, 6H), 1 .93 (t, J = 8.0 Hz, 6H).
947 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1 H), 8.73 (s, 1 H), 8.55 (s,
1 H), 8.32 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.0 Hz, 1 H), 5.30 (d, J = 48.9 Hz, 1 H), 4.84 - 4.74 (m, 1 H),
4.43 (t, J = 12.3 Hz, 2H), 3.99 - 3.82 (m, 1 H), 2.33 - 2.23 (m, 6H), 1.99 - 1 .88 (m, 6H), 1.44 - 1.1 1 (m, 1 H).
948 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (s, 1 H), 8.73 (d, J = 2.1 Hz, 1 H), 8.56 (s,
1 H), 8.34 (s, 1 H), 7.96 (d, J = 5.0 Hz, 1 H), 7.25 (d, J = 5.0 Hz, 1 H), 5.74 - 5.54 (m, 2H), 3.88 (d, J = 25.6 Hz, 2H),
2.99 (s, 3H), 2.28 (t, J = 7.7 Hz, 6H), 1.93 (t, J = 8.0 Hz, 7H).
949 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1 H), 8.73 (d, J = 2.1 Hz,
1 H), 8.57 (s, 1 H), 8.34 (s, 1 H), 7.96 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 3.74 (s, 3H), 2.29 (dd, J = 9.4, 6.4 Hz, 6H), 1 .94 (t, J = 8.0 Hz, 6H), 1.64 (q, J = 4.9 Hz, 2H), 1 .30 (q, J = 4.9 Hz, 2H).
950 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (d, J = 2.1 Hz, 1 H), 8.72 (d, J = 2.1 Hz,
1 H), 8.48 (s, 1 H), 8.30 (s, 1 H), 7.94 (d, J = 5.1 Hz, 1 H), 7.24 (d, J = 5.1 Hz, 1 H), 2.28 (dd, J = 10.5, 5.5 Hz, 6H), 1 .94 (dd, J = 10.1 , 5.8 Hz, 6H), 1 .46 (s, 3H), 0.87 (d, J = 5.4 Hz, 2H), 0.75 (t, J = 3.4 Hz, 2H).
951 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.57 (s, 1 H), 8.35 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 6.06 (t, J = 57.5 Hz, 1 H), 2.34 - 2.23 (m, 6H), 1 .94 (t, J = 8.0 Hz, 6H), 1.28 - 1.21 (m, 2H), 1.07 (s, 2H).
952 1 H NMR (400 MHz, Methanol-d4) δ 8.84 - 8.75 (m, 2H), 8.61 (s, 1 H), 8.02 (d, J =
5.5 Hz, 1 H), 7.85 (s, 1 H), 7.24 (d, J = 5.0 Hz, 1 H), 4.76 (t, J = 11 .9 Hz, 2H), 4.45 (t, compound 1 H-NMR
J = 1 1.6 Hz, 3H), 4.13 (s, 2H), 3.71 (s, 3H), 3.02 (s, 1 H), 2.89 (s, 1 H), 2.57 (s, 1 H), 2.48 (s, 2H), 2.31 (t, J = 9.4 Hz, 2H), 1.40 (dd, J = 6.7, 3.3 Hz, 4H), 1.32 (s, 1 H).
953 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (s, 1 H), 8.73 (d, J = 2.2 Hz, 1 H), 8.62 (s,
1 H), 8.33 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.2 Hz, 1 H), 4.51 (d, J = 34.0 Hz, 1 H), 4.33 - 4.13 (m, 1 H),
4.18 (s, 1 H), 3.76 - 3.69 (m, 2H), 3.53 (d, J = 18.7 Hz, 2H), 3.16 (s, 1 H), 2.27 (t, J = 8.0 Hz, 6H), 1.93 (t, J = 7.9 Hz, 6H).
954 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (s, 1 H), 8.73 (s, 1 H), 8.61 (s, 1 H), 8.32 (s,
1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.2 Hz, 1 H), 4.25 - 4.15 (m, 2H), 4.03 (s, 1 H), 3.95 (q, J = 10.4 Hz, 2H), 2.26 (d, J = 8.7 Hz, 6H), 1.94 (d, J = 8.4 Hz, 6H), 1.55 (s, 3H).
955 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1 H), 8.73 (d, J = 2.1 Hz,
1 H), 8.59 (s, 1 H), 8.34 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 5.15 (dd, J = 5.2, 2.2 Hz, 2H), 3.69 (t, J = 5.6 Hz, 1 H), 3.47 (dd, J = 6.1 , 2.1 Hz, 1 H), 2.28 (t, J = 7.9 Hz, 6H), 1.93 (t, J = 7.7 Hz, 6H).
956 1 H NMR (400 MHz, Methanol-d4) δ 10.01 (s, 1 H), 8.80 (d, J = 9.2 Hz, 2H), 8.71 (d,
J = 7.6 Hz, 2H), 8.11 (d, J = 16.6 Hz, 3H), 7.93 (d, J = 4.7 Hz, 1 H), 7.26 (d, J = 8.2 Hz, 1 H), 7.20 (d, J = 5.1 Hz, 1 H), 1.68 (s, 4H), 1.34 (s, 6H).
957 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.2 Hz, 1 H), 8.73 (d, J = 2.1 Hz,
1 H), 8.57 (s, 1 H), 8.32 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 4.53 (t, J = 8.6 Hz, 1 H), 2.27 (q, J = 11 .0, 9.4 Hz, 7H), 2.09 - 1.87 (m, 11 H).
958 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (s, 1 H), 8.72 (s, 1 H), 8.57 (s, 1 H), 8.33 (s,
1 H), 7.94 (d, J = 5.0 Hz, 2H), 7.24 (d, J = 5.0 Hz, 1 H), 2.27 (d, J = 8.0 Hz, 10H), 2.08 - 1.84 (m, 14H).
959 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.33 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 4.74 (dd, J = 10.6, 8.8 Hz, 1 H), 3.50 - 3.41 (m, 2H), 2.59 (s, 1 H), 2.28 (t, J = 8.0 Hz, 6H), 2.25 - 2.14 (m, 1 H), 1.93 (t, J = 7.9 Hz, 6H).
960 1 H NMR (400 MHz, Methanol-d4) δ 8.79 (d, J = 2.1 Hz, 1 H), 8.73 (d, J = 2.2 Hz,
1 H), 8.60 (s, 1 H), 8.33 (s, 1 H), 7.95 (d, J = 5.1 Hz, 1 H), 7.25 (d, J = 5.1 Hz, 1 H), 4.74 (dd, J = 10.6, 8.9 Hz, 1 H), 3.53 - 3.41 (m, 2H), 2.58 (d, J = 6.2 Hz, 1 H), 2.28 (t, J = 7.9 Hz, 6H), 2.24 - 2.16 (m, 1 H), 1.93 (t, J = 8.0 Hz, 6H).
961 1 H NMR (400 MHz, Methanol-d4) δ 8.76 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.1 Hz,
1 H), 8.54 (s, 1 H), 8.31 (s, 1 H), 7.93 (d, J = 5.1 Hz, 1 H), 7.22 (d, J = 5.1 Hz, 1 H), 4.45 (t, J = 12.0 Hz, 2H), 4.06 (t,
J = 14.2 Hz, 2H), 2.31 - 2.18 (m, 7H), 1 .96 - 1.86 (m, 7H).
962 1 H NMR (400 MHz, Methanol-d4) δ 8.69 (d, J = 2.3 Hz, 1 H), 8.59 (d, J = 2.3 Hz,
1 H), 8.52 (s, 1 H), 8.40 (s, 1 H), 7.96 (d, J = 5.2 Hz, 1 H), 7.23 (d, J = 5.0 Hz, 1 H), 3.96 (t, J = 13.7 Hz, 2H), 3.48 (q,
J = 7.1 Hz, 4H), 3.16 - 3.10 (m, 1 H), 2.99 (s, 1 H), 2.85 (s, 1 H), 2.26 (t, J = 7.9 Hz, 6H), 2.02 (s, 1 H), 1.90 (t, J = 7.9 Hz, 6H), 1 .36 (dd, J = 6.7, 3.2 Hz, 2H), 1.28 (s, 1 H), 1.17 (t, J = 7.0 Hz, 5
H), 0.92 - 0.84 (m, 1 H).
963 1 H NMR (400 MHz, Methanol-d4) δ 8.70 (s, 2H), 8.53 (s, 1 H), 8.42 (s, 1 H), 7.97 (d,
J = 5.0 Hz, 1 H), 7.29 (d, J = 5.1 Hz, 1 H), 5.02 (t, J = 1 1.3 Hz, 2H), 4.92 (d, J = 11 .4 Hz, 2H), 3.99 (t, J = 14.0 Hz, 2H), 3.48 (q, J = 7.1 Hz, OH), 2.98 (d, J = 2.3 Hz, 2H), 2.33 - 2.18 (m, 6H), 2.02 (s, OH), 1.96 - 1.87 (m, 6H), 1.28 (s, OH), 1.17 (t, J = 7.0 Hz, OH), 0.88 (d, J = 7.6 Hz, OH).
964 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (d, J = 2.2 Hz, 1 H), 8.69 (d, J = 2.2 Hz,
1 H), 8.51 (s, 1 H), 8.29 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 4.47 (d, J = 48.9 Hz, 2H), 2.31 - 2.20 (m, 7H), 1 .96 - 1 .84 (m, 6H), 0.99 (d, J = 5.2 Hz, 4H).
965 1 H NMR (400 MHz, Methanol-d4) δ 8.75 (s, 1 H), 8.71 (d, J = 2.2 Hz, 1 H), 8.60 (d,
J = 2.2 Hz, 1 H), 8.54 (dd, J = 2.8, 0.7 Hz, 1 H), 8.12 (s, 1 H), 7.97 (dd, J = 8.5, 2.8 Hz, 1 H), 7.85 (d, J = 5.1 Hz, 1 H), 7.68 (dd, J = 8.5, 0.7 Hz, 1 H), 7.16 (d, J = 5.1 Hz, 1 H), 4.46 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 3.99 (ddd, J = 36.4, 14.6, 2.1 Hz, 1 H), 3.53 (ddd, J = 16.2, 14.6, 9.3 Hz, 1 H), 1 .30 (d, J = 1 .7 Hz, 6H).
966 1 H NMR (400 MHz, Methanol-d4) δ 9.06 (s, 2H), 8.78 (s, 1 H), 8.71 (d, J = 2.2 Hz,
1 H), 8.64 (dd, J = 5.9, 2.2 Hz, 2H), 8.54 (d, J = 2.2 Hz, 1 H), 8.29 (s, 1 H), 7.94 (dd, J = 31.8, 5.0 Hz, 2H), 7.14 (dd, J = 14.6, 5.0 Hz, 2H), 5.48 (s, OH), 4.49 (dd, J = 48.9, 9.2 Hz, 1 H), 4.09 (q, J = 7.1 Hz, OH), 4.05 - 3.94 (m, 1 H), 3.55 (td, J = 15.5, 9.4 Hz, 1 H), 2.00 (s, OH), 1.30 (d, J = 1 .6 Hz, 6H), 1.29 - 1.26 (m, OH), 1.23 (t, J = 7.1 Hz, OH).
967 n/a
968 1 H NMR (400 MHz, Methanol-d4) δ 8.73 (s, 1 H), 8.66 (d, J = 2.2 Hz, 1 H), 8.54 (d,
J = 2.2 Hz, 1 H), 8.45 (s, 1 H), 8.20 (d, J = 8.6 Hz, 2H), 7.82 (d, J = 5.0 Hz, 1 H), 7.62 (d, J = 8.6 Hz, 2H), 7.14 (d, J = 5.0 Hz, 1 H), 5.48 (s, 1 H), 4.47 (dd, J = 48.2, compound 1 H-NMR
8.4 Hz, 1 H), 3.99 (dd, J = 36.3, 14.5 Hz, 1 H), 3.62 - 3.44 (m, 1 H), 2.69 (s, 3H), 1.30 (d, J = 1.6 Hz, 6H).
969 n/a
970 1 H NMR (400 MHz, Methanol-d4) δ 9.98 (s, 1 H), 8.83 (s, 1 H), 8.56 (d, J = 10.5 Hz,
2H), 8.47 (s, 1 H), 8.24 (s, 1 H), 7.86 (s, 1 H), 7.07 (s, 1 H), 4.62 - 4.30 (m, 1 H), 4.07 - 3.82 (m, 1 H), 3.61 - 3.48 (m, 1 H), 2.21 (t, J = 7.6 Hz, 1 H), 1.92 (s, 2H), 1.58 (s, 1 H), 1.29 (d, J = 9.3 Hz, 33H), 0.88 (d, J = 7.1 Hz, 2H).
971 1 H NMR (400 MHz, Methanol-d4) δ 8.89 (s, 2H), 8.79 (s, 1 H), 8.73 (d, J = 2.1 Hz,
1 H), 8.62 (d, J = 2.2 Hz, 1 H), 8.09 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.17 (d, J = 5.1 Hz, 1 H), 4.47 (ddd, J = 49.0, 9.2, 1 .9 Hz, 1 H), 3.99 (ddd, J = 36.3, 14.5, 1.7 Hz, 2H), 3.54 (ddd, J = 16.1 , 14.7, 9.4 Hz, 2H), 1 .29 (d, J = 1 .7 Hz, 6H).
972 1 H NMR (400 MHz, Methanol-d4) δ 10.04 (s, 1 H), 8.84 (d, J = 1.5 Hz, 1 H), 8.80 (s,
1 H), 8.75 (d, J = 2.2 Hz, 1 H), 8.70 (d, J = 2.1 Hz, 1 H), 8.47 (d, J = 1.4 Hz, 1 H), 8.24 (s, 2H), 7.93 (d, J = 4.9 Hz,
1 H), 7.19 (d, J = 5.0 Hz, 1 H), 4.49 (ddd, J = 49.3, 9.1 , 1.9 Hz, 1 H), 4.00 (ddd, J = 36.1 , 14.7, 1.8 Hz, 1 H), 3.65 - 3.48 (m, 1 H), 1.32 (s, 6H).
973 1 H NMR (400 MHz, Methanol-d4) δ 9.33 (d, J = 0.8 Hz, 1 H), 8.83 (dd, J = 1.9, 1.0
Hz, 1 H), 8.81 (s, 1 H), 8.74 (d, J = 2.2 Hz, 1 H), 8.60 (d, J = 2.2 Hz, 1 H), 8.03 (dt, J = 9.7, 0.9 Hz, 1 H), 8.00 (s, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.69 (dd, J = 9.7, 1.9 Hz, 1 H), 7.17 (d, J = 5.1 Hz, 1 H), 4.50 (ddd, J = 49.1 , 9.3, 2.1 Hz, 1 H), 4.03 (ddd, J = 36.7, 14.6, 2.1 Hz, 1 H), 3.64 - 3.51 (m, 1 H), 1.33 (d, J = 1.7 Hz, 6H).
974 1 H NMR (400 MHz, Methanol-d4) δ 9.08 (t, J = 1.4 Hz, 1 H), 8.85 (s, 1 H), 8.72 (d, J
= 2.2 Hz, 1 H), 8.56 (d, J = 2.2 Hz, 1 H), 8.33 (d, J = 2.1 Hz, 1 H), 8.17 (d, J = 2.2 Hz, 1 H), 8.15 (s, 1 H), 8.13 (s, 1 H), 8.13 (d, J = 2.9 Hz, 1 H), 7.91 (d, J = 5.1 Hz, 1 H), 7.16 (d, J = 5.1 Hz, 1 H), 4.50 (ddd, J = 49.0, 9.3, 2.1 Hz, 1 H), 4.01 (ddd, J = 36.5, 14.6, 2.1 Hz, 1 H), 3.66 - 3.52 (m, 1 H), 1.33 (d, J = 1.7 Hz, 6H).
975 1 H NMR (400 MHz, Methanol-d4) δ 8.78 (s, 1 H), 8.76 - 8.72 (m, 2H), 8.57 (d, J =
2.2 Hz, 1 H), 8.37 (s, 1 H), 8.08 (d, J = 2.4 Hz, 1 H), 7.88 (d, J = 5.1 Hz, 1 H), 7.85 - 7.82 (m, 1 H), 7.19 (d, J = 5.1 Hz, 1 H), 7.03 (dd, J = 7.4, 2.4 Hz, 1 H), 6.76 (dd, J = 2.4, 0.9 Hz, 1 H), 4.50 (ddd, J = 49.0, 9.4, 2.1 Hz, 1 H), 4.03 (ddd, J = 36.7, 14.7, 2.1 Hz, 1 H), 3.56 (ddd, J = 16.1 , 14.7, 9.4 Hz, 1 H), 1.33 (d, J
= 1.6 Hz, 6H).
BIOLOGICAL ASSAYS
Biological assays were conducted to measure activity against TNFa and IRAK4. As summarized in Table 3, the test compounds are inhibitors of IRAK4. IRAK4 Monocyte TNFa Cell Based Assay Procedure:
Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX™ (Gibco® 200mM L-alanyl-L-glutamine) (lOmM HEPES, IX Pen-Strep, 55 μΜ β-mercaptoethanol, 1 mM Sodium pyruvate) media containing 10% FBS to 0.125 X106 cells/ml and recovered at 37°C for 2 hours. The cell suspension was then plated at a density of 5,000 cells/well onto black 384 well Greiner clear bottom plates. Plates were pre-spotted with test compounds and serially diluted in DMSO where 200 nL/well were delivered using the Echo 550 acoustic liquid dispenser (Labcyte®) for a final DMSO concentration of 0.5%. Plated cells were treated with compound for 1 hour at 37 °C. Cells were then stimulated with 50 pg/ml of LPS (Sigma) excluding outside columns of plate used for unstimulated cell control wells. Cells were incubated for an additional 4 hours at 37 °C. Cells were then spun out of the media and 5 μΐ of sample were taken and analyzed for total TNFa content using the TR-FRET Human TNFa detection system (CisBio). This system utilizes two labeled antibodies (cryptate and XL665) that bind to two different epitopes of the TNFa molecule and produce FRET signal proportional to the concentration of TNFa in the sample. Detection antibodies are mixed 50:50 and 5 were dispensed into each well. Plates were covered with clear seals and incubated at room temp overnight. The following morning plates were read using an Envision 2103 Multilabeled reader (PerkinElmer) with
excitation/emission/FRET emission at 340 nm/615 nm/665 nm, respectively.
Fluorescence intensities at 615 nm and 665 nm emission wavelengths were expressed as a ratio (665 nm/615 nm). Percent of control was calculated as follows:
% Control = 100 X (Ratio Sample - Ratio o% Stimulation)/(Ratio 100% Stimulation - Ratio 0% Stimulation) where unstimulated cells (0% stimulation) were the negative control and stimulated cells (100% stimulation) were used as the positive control. IRAK4 Biochemical Assay Procedure:
IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibody against the phosphorylated peptide substrate. This is a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay, based on the STK1 KinEASE Assay (Cisbio, Bedford, Massachusetts). The assay was designed as a simple two-step, endpoint assay (a 5 μΐ enzyme reaction followed by 5μ1 stop and detect Solution) performed in ProxiPlate-384 Plus plates (Perkin Elmer, Waltham, Massachusetts).
Staurosporine, a non-selective kinase inhibitor was used as a positive control.
Compounds diluted in DMSO were spotted into 384 well plates using a Labcyte® Echo 550 Liquid Handling System prior to addition of IRAK4 enzyme and peptide substrate. Reaction solutions were delivered using a Multi-Flo (Bio-Tek Instruments). The enzyme and peptide solution was incubated with compound for 15 minutes at room temp before the reaction was initiated by the addition of ATP. The standard 5μ1 reaction mixture contained 500 DM ATP, 2 DM peptide (STK1 Peptide), 0.75 nM of IRAK4 in reaction buffer (50 mM HEPES, pH 7.0, 0.02% NaN3, 0.01% BSA, 0.1 mM Orthovanadate, 5 mM MgCl2, 0.025% NP-40, ImM DTT). After 120 min of incubation at room temperature, 5 Dl of Stop and Detect Solution (1:100 Cryptate labeled anti- phosphorylated peptide antibody solution and 125 nM Tracer in a 50mM HEPES pH 7.0 detection buffer containing sufficient EDTA) was added. The plate was then further incubated for 60 minutes at room temperature and read on Envision 2103 Multilabeled reader (PerkinElmer) with excitation/emission/FRET emission at 340nm/615nm/665nm, respectively. Fluorescence intensities at 615nm and 665nm emission wavelengths were expressed as a ratio (665nm/615nm). Percentage of inhibition was calculated as below:
% Inhibition = 100 x (Ratio sample - Ratio 0% inhibition)/(Ratio i0o% inhibition - Ratio 0% inhibition)
The 0% inhibition value comes from control wells lacking inhibitor. The 100% inhibition value comes from control wells containing a saturating amount of known inhibitor staurosporine.
Table 3
Figure imgf000467_0001
compound EC50 TNF(nM) IC50 HTRF (nM)
33 29 <1
34 >10000 9377
35 218 3
36 221 15
37 283 12
38 91 2
39 507 4
40 73 <1
41 78 <1
42 35 <1
43 30 <1
44 >10000 6627
45 255 10
46 37 <1
47 37 <1
48 28 <1
49 8 <1
50 351 3
51 159 n/a
52 86 n/a
53 65 <1
54 26 <1
55 28 n/a
56 13 <1
57 46 <1
58 91 <1
59 57 <1
60 512 1
61 89 <1
62 83 <1
63 57 <1
64 70 <1
65 149 2
66 458 46
67 43 <1
68 327 3
69 515 7
70 47 <1
71 298 9
72 159 4
73 119 3
74 1097 2
75 544 3
76 348 1
77 352 2
78 1625 27
79 1823 18
80 88 <1
81 134 1
82 79 <1
83 221 1
84 58 <1
85 67 1
86 321 4
87 160 1
88 209 3
89 16 <1
90 417 3 compound EC50 TNF(nM) IC50 HTRF (nM)
91 62 <1
92 80 2
93 78 1
94 92 1
95 42 1
96 79 2
97 180 2
98 358 2
99 130 1
100 195 4
101 82 <1
102 313 2
103 75 <1
104 274 6
105 3165 9
106 1384 3
107 961 17
108 >10000 88
109 n/a n/a
110 191 4
111 n/a n/a
112 399 4
113 3671 22
114 177 4
115 196 4
116 98 <1
117 47 <1
118 25 <1
119 32 <1
120 430 8
121 365 7
122 867 17
123 421 6
124 182 3
125 114 1
126 92 1
127 112 <1
128 141 1
129 377 6
130 221 3
131 154 1
132 222 5
133 91 1
134 101 1
135 130 2
136 163 2
137 140 2
138 117 1
139 254 19
140 58 <1
141 70 <1
142 169 4
143 720 18
144 >10000 656
145 70 <1
146 117 1
147 47 <1
148 206 2 compound EC50 TNF(nM) IC50 HTRF (nM)
149 148 1
150 51 <1
151 96 <1
152 191 2
153 91 <1
154 34 <1
155 150 1
156 179 4
157 501 23
158 99 2
159 184 1
160 >10000 465
161 >10000 1000
162 >10000 376
163 >10000 90
164 9941 132
165 >10000 59
166 >10000 741
167 >10000 1000
168 >10000 1000
169 >10000 183
170 217 3
171 382 6
172 76 <1
173 148 2
174 92 1
175 20 <1
176 >10000 1
177 29 <1
178 10 <1
179 59 1
180 34 <1
181 >10000 1000
182 70 1
183 657 6
184 48 <1
185 46 <1
186 145 1
187 152 1
188 275 8
189 136 6
190 209 8
191 128 4
192 157 5
193 141 3
194 48 <1
195 37 <1
196 53 2
197 42 1
198 16 <1
199 82 <1
200 15 1
201 11 1
202 22 <1
203 44 <1
204 27 <1
205 115 1
206 133 1 compound EC50 TNF(nM) IC50 HTRF (nM)
207 96 1
208 92 <1
209 84 <1
210 39 <1
211 50 1
212 13 <1
213 51 <1
214 36 3
215 53 2
216 32 <1
217 63 <1
218 41 <1
219 209 1
220 123 1
221 98 <1
222 151 1
223 13 <1
224 75 1
225 6 <1
226 75 <1
227 31 <1
228 114 2
229 135 1
230 58 <1
231 61 <1
232 425 1
233 170 1
234 33 <1
235 166 2
236 379 1
237 23 1
238 225 <1
239 24 <1
240 27 1
241 16 <1
242 191 2
243 218 2
244 102 1
245 92 2
246 637 17
247 262 6
248 545 3
249 100 2
250 37 1
251 117 1
252 78 2
253 510 3
254 2019 17
255 1274 14
256 389 2
257 129 1
258 83 1
259 152 6
260 165 8
261 41 <1
262 21 <1
263 193 3
264 n/a n/a compound EC50 TNF(nM) IC50 HTRF (nM)
265 690 2
266 7593 131
267 19 <1
268 29 <1
269 59 1
270 49 1
271 38 1
272 23 1
273 22 2
274 144 1
275 154 3
276 146 3
277 383 5
278 165 3
279 29 2
280 55 1
281 37 1
282 364 2
283 14 1
284 88 1
285 167 2
286 41 1
287 147 1
288 54 1
289 66 1
290 121 1
291 90 2
292 37 1
293 49 1
294 735 3
295 38 1
296 391 3
297 80 1
298 214 2
299 128 1
300 75 1
301 1410 2
302 61 1
303 26 <1
304 677 4
305 337 1
306 453 3
307 320 2
308 46 <1
309 623 2
310 362 2
311 15 <1
312 198 2
313 37 1
314 20 <1
315 59 <1
316 136 <1
317 11 <1
318 23 <1
319 2222 19
320 1906 3
321 38 <1
322 169 5 compound EC50 TNF(nM) IC50 HTRF (nM)
323 187 5
324 157 2
325 228 3
326 56 <1
327 738 1
328 300 6
329 62 1
330 171 6
331 25 <1
332 43 <1
333 87 <1
334 292 <1
335 100 3
336 522 5
337 73 5
338 304 3
339 264 1
340 139 1
341 16 <1
342 83 1
343 38 1
344 48 2
345 116 1
346 18 1
347 45 2
348 19 <1
349 77 1
350 12 <1
351 120 2
352 76 1
353 16 <1
354 19 <1
355 23 <1
356 800 6
357 413 9
358 122 3
359 >10000 614
360 >10000 2
361 50 1
362 1433 9
363 328 5
364 >10000 1000
365 415 4
366 162 1
367 1565 3
368 2887 5
369 922 16
370 10 1
371 61 <1
372 8 <1
373 141 <1
374 327 1
375 110 1
376 736 2
377 426 2
378 38 <1
379 57 2
380 773 15 compound EC50 TNF(nM) IC50 HTRF (nM)
381 18 <1
382 586 10
383 144 <1
384 129 1
385 36 <1
386 2382 8
387 112 2
388 96 1
389 137 3
390 >10000 6
391 33 <1
392 50 <1
393 44 <1
394 68 1
395 256 3
396 24 1
397 30 1
398 17 <1
399 8 <1
400 21 1
401 65 2
402 77 2
403 14 <1
404 11 1
405 12 1
406 33 1
407 20 2
408 31 1
409 17 1
410 50 2
411 62 2
412 44 1
413 98 <1
414 178 12
415 14 1
416 16 1
417 151 5
418 36 1
419 127 3
420 122 6
421 24 2
422 76 2
423 94 2
424 18 1
425 120 2
426 591 5
427 278 2
428 4271 63
429 36 1
430 488 14
431 441 1 1
432 37 <1
433 47 <1
434 107 <1
435 >10000 10000
436 34 <1
437 76 1
438 135 1 compound EC50 TNF(nM) IC50 HTRF (nM)
439 40 <1
440 715 2
441 1304 1 1
442 104 1
443 110 1
444 9 <1
445 59 1
446 63 1
447 286 5
448 2041 32
449 361 3
450 44 <1
451 30 <1
452 112 <1
453 68 <1
454 207 <1
455 118 1
456 394 1
457 370 3
458 2467 3
459 125 1
460 71 <1
461 57 <1
462 67 <1
463 163 3
464 1107 23
465 41 1 8
466 259 8
467 167 4
468 112 1
469 1096 41
470 440 25
471 74 9
472 5410 43
473 33 1
474 23 <1
475 16 <1
476 27 <1
477 98 1
478 73 1
479 71 <1
480 92 2
481 63 2
482 48 1
483 64 1
484 63 1
485 39 1
486 64 1
487 51 <1
488 71 1
489 121 2
490 220 7
491 219 19
492 101 1
493 >10000 12
494 44 <1
495 40 <1
496 42 <1 compound EC50 TNF(nM) IC50 HTRF (nM)
497 55 1
498 43 1
499 20 1
500 13 1
501 63 2
502 93 1
503 46 2
504 14 <1
505 139 1
506 50 <1
507 27 <1
508 22 <1
509 66 <1
510 39 <1
511 26 <1
512 98 3
513 110 2
514 213 9
515 526 5
516 595 2
517 484 <1
518 13 <1
519 34 <1
520 45 <1
521 717 62
522 23 <1
523 412 14
524 97 1
525 11 <1
526 99 1
527 16 <1
528 65 1
529 62 1
530 10 <1
531 34 <1
532 122 1
533 70 <1
534 26 <1
535 999 2
536 16 <1
537 18 1
538 50 <1
539 12 <1
540 12 <1
541 65 <1
542 27 <1
543 49 2
544 81 1
545 5 <1
546 90 1
547 28 <1
548 22 1
549 149 2
550 364 2
551 809 1 1
552 1157 7
553 183 2
554 439 35 compound EC50 TNF(nM) IC50 HTRF (nM)
555 95 1
556 18 1
557 27 <1
558 190 <1
559 78 1
560 83 <1
561 121 1
562 75 1
563 114 2
564 315 23
565 23 <1
566 27 <1
567 50 <1
568 214 <1
569 >10000 743
570 80 <1
571 12 <1
572 66 <1
573 24 <1
574 57 <1
575 144 2
576 21 <1
577 30 <1
578 14 2
579 75 <1
580 69 <1
581 114 <1
582 389 3
583 140 2
584 274 4
585 104 2
586 118 1
587 150 3
588 412 3
589 95 <1
590 38 <1
591 180 2
592 222 1
593 143 2
594 316 2
595 107 <1
596 >10000 3
597 106 1
598 106 <1
599 68 <1
600 72 <1
601 64 <1
602 70 <1
603 81 1
604 283 7
605 24 <1
606 33 1
607 1444 1 1
608 123 1
609 35 <1
610 50 <1
611 >10000 15
612 51 <1 compound EC50 TNF(nM) IC50 HTRF (nM)
613 15 <1
614 156 2
615 46 <1
616 144 2
617 144 2
618 335 4
619 168 3
620 54 1
621 98 1
622 407 2
623 63 <1
624 1644 3
625 22 <1
626 79 <1
627 30 <1
628 26 <1
629 22 <1
630 9 <1
631 21 2
632 28 <1
633 2 <1
634 7 <1
635 >10000 8
636 33 <1
637 21 <1
638 26 <1
639 43 1
640 117 1
641 21 <1
642 13 <1
643 8 <1
644 36 1
645 301 10
646 15 <1
647 48 <1
648 51 1
649 >10000 21
650 16 <1
651 188 5
652 188 2
653 201 3
654 15 <1
655 27 <1
656 40 <1
657 23 <1
658 37 <1
659 16 <1
660 64 1
661 19 <1
662 12 <1
663 52 <1
664 14 <1
665 299 8
666 30 <1
667 45 <1
668 165 1
669 4 <1
670 >10000 93 compound EC50 TNF(nM) IC50 HTRF (nM)
671 22 <1
672 66 <1
673 19 <1
674 67 <1
675 23 <1
676 81 1
677 54 <1
678 9 <1
679 17 <1
680 15 <1
681 6 <1
682 22 1
683 45 1
684 89 1
685 398 10
686 20 <1
687 42 <1
688 24 <1
689 180 1
690 71 1
691 345 5
692 315 1
693 821 35
694 102 <1
695 15 <1
696 103 <1
697 171 1
698 201 3
699 36 <1
700 151 2
701 191 4
702 119 <1
703 45 <1
704 69 1
705 n/a n/a
706 n/a n/a
707 42 1
708 57 1
709 151 3
710 183 4
711 231 2
712 47 <1
713 264 2
714 35 <1
715 57 1
716 55 <1
717 66 <1
718 280 2
719 11 <1
720 243 2
721 87 1
722 35 <1
723 793 7
724 59 <1
725 23 <1
726 169 4
727 203 3
728 4 <1 compound EC50 TNF(nM) IC50 HTRF (nM)
729 58 1
730 40 <1
731 59 <1
732 89 1
733 248 2
734 29 <1
735 100 1
736 48 <1
737 26 <1
738 29 <1
739 277 4
740 265 4
741 124 <1
742 126 1
743 54 <1
744 157 2
745 87 <1
746 105 1
747 169 2
748 38 <1
749 52 <1
750 198 1
751 333 4
752 80 <1
753 225 7
754 20 <1
755 16 1
756 59 1
757 12 <1
758 11 1
759 >10000 3
760 33 <1
761 26 <1
762 7 <1
763 155 <1
764 8 <1
765 323 6
766 38 <1
767 35 <1
768 24 <1
769 44 <1
770 50 <1
771 37 <1
772 14 <1
773 43 1
774 2
775 25 <1
776 32 1
777 15 <1
778 51 <1
779 28 <1
780 38 1
781 90 <1
782 29 <1
783 22 <1
784 40 <1
785 23 <1
786 323 2 compound EC50 TNF(nM) IC50 HTRF (nM)
787 79 <1
788 90 <1
789 20 <1
790 21 <1
791 45 1
792 86 2
793 598 3
794 997 2
795 >10000 7
796 75 2
797 38 1
798 42 1
799 62 <1
800 133 3
801 57 1
802 157 2
803 327 1
804 48 <1
805 129 <1
806 349 3
807 75 2
808 15 <1
809 166 1
810 9 <1
811 32 <1
812 38 <1
813 92 <1
814 40 <1
815 15 <1
816 41 <1
817 165 6
818 224 4
819 27 <1
820 59 <1
821 51 <1
822 73 1
823 47 <1
824 39 <1
825 48 <1
826 32 <1
827 15 <1
828 12 <1
829 23 <1
830 23 <1
831 49 <1
832 132 1
833 192 1
834 23 <1
835 8 <1
836 43 2
837 117 3
838 >10000 57
839 307 1
840 17 <1
841 29 <1
842 42 <1
843 137 1
844 70 1 compound EC50 TNF(nM) IC50 HTRF (nM)
845 >10000 <1
846 97 2
847 69 <1
848 112 2
849 11 <1
850 10 <1
851 12 <1
852 3 n/a
853 127 14
854 10 1
855 9 <1
856 24 1
857 9 <1
858 20 <1
859 89 3
860 31 2
861 16 <1
862 46 <1
863 74 <1
864 69 <1
865 n/a n/a
866 37 1
867 6 <1
868 53 <1
869 14 <1
870 81 1
871 51 1
872 14 <1
873 102 <1
874 13 <1
875 64 2
876 24 <1
877 46 2
878 141 2
879 225 1
880 58 <1
881 84 <1
882 22 <1
883 90 <1
884 29 2
885 70 1
886 29 2
887 88 1
888 21 <1
889 436 9
890 357 14
891 249 4
892 808 3
893 217 2
894 245 7
895 1000 2
896 48 <1
897 421 2
898 118 <1
899 >10000 5
900 134 2
901 126 3
902 1227 1 compound EC50 TNF(nM) IC50 HTRF (nM)
903 79 1
904 117 1
905 >10000 15
906 186 10
907 91 10
908 61 1 6
909 372 15
910 1214 10
911 318 7
912 176 6
913 226 3
914 13 <1
915 28 1
916 88 3
917 72 1
918 416 31
919 707 37
920 8 <1
921 45 <1
922 42 <1
923 52 <1
924 119 1
925 583 4
926 192 2
927 22 <1
928 71 1
929 126 1
930 147 2
931 163 3
932 168 3
933 269 4
934 271 3
935 153 2
936 >10000 147
937 133 2
938 68 1
939 >10000 642
940 44 <1
941 19 <1
942 587 8
943 836 35
944 209 <1
945 116 1
946 120 1
947 207 <1
948 282 3
949 62 1
950 70 1
951 159 2
952 62 <1
953 240 <1
954 213 <1
955 399 <1
956 31 <1
957 173 <1
958 219 1
959 206 <1
960 316 1 compound EC50 TNF(nM) IC50 HTRF (nM)
961 382 2
962 >10000 650
963 >10000 394
964 68 1
965 26 <1
966 >10000 2
967 156 3
968 81 1
969 n/a <1
970 57 <1
971 74 <1
972 12 <1
973 1907 2
974 112 1
975 67 <1

Claims

CLAIMS What is claimed:
1. A compound of
Figure imgf000485_0001
(I)
wherein:
R1 and R2 are each independently selected from:
a) Ci-io alkyl optionally substituted with Z ;
b) C3-10 cycloalkyl optionally substituted with Z1;
c) 5-10 membered heteroaryl optionally substituted with Z1;
d) C6-io aryl optionally substituted with Z1;
e) 4-7 membered monocyclic heterocyclyl optionally substituted with Z1 ; f) 6-12 membered bicyclic heterocyclyl optionally substituted with Z1; or g) -N(R12)( R ), -S(0)2R12, -S(0)2N(R12)( R ), or -H;
R3 and R4 are each independently selected from:
a) H, halo, -N02, -CN, -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R12)(
R12), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)S(0)2(R12), -N(R12)C(0)- N(R12)( R12), -S(0)2R12 or -S(0)2N(R12)( R12);
b) Ci-9 alkyl optionally substituted with Z1;
c) C2_9 alkynyl optionally substituted with Z1;
d) C2_9 alkenyl optionally substituted with Z1;
e) 5-10 membered heteroaryl optionally substituted with Z1;
f) C6-io aryl optionally substituted with Z1;
g) 4-12 membered heterocyclyl optionally substituted with Z1; or
h) C3-10 cycloalkyl optionally substituted with Z1;
R5, R6 and R7 are each independently selected from: a) H, halo, -N02, -CN, -O-R , -C(0)-R , -C(0)-N(R1Z)( R1Z), -N(R1Z)( R12), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, or -N(R12)S(0)2(R12; b) Ci-5 alkyl optionally substituted with Z1 ; or
c) Cyclopropyl, oxetanyl or azetidinyl optionally substituted with Z1 ;
Z1 is independently oxo, halo, -NO2, -N3, -CN, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)-R12, -C(0)0- R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0- R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S- R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zla; each Zla is independently oxo, halo, -NO2, -CN, -N3, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12
or -S(0)2N(R12)( R12);
wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zlb; each R12 is independently H, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl or heterocyclyl;
wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zla; each Zlb is independently oxo, hydroxy, halo, -NO2, -N3, -CN, C1-9 alkyl, C2-6 alkenyl, C2- 6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -0(Ci_9 alkyl), -0(C2-6 alkenyl), -0(C2-6 alkynyl), -0(C3-i5 cycloalkyl), -0(Ci_8 haloalkyl), - O(aryl), -O(heteroaryl), -O(heterocyclyl), -NH2, -NH(Ci_9 alkyl), -NH(C2-6
alkenyl), -NH(C2-6 alkynyl), -NH(C3-15 cycloalkyl), -NH(Ci_8 haloalkyl), -NH(aryl), - NH(heteroaryl), -NH(heterocyclyl), -N(C1-9 alkyl)2, -N(C3-15 cycloalkyl)2, -N(C2-6 alkenyl)2, -N(C2-6 alkynyl)2, -N(C3-i5 cycloalkyl)2, -N(Ci-8 haloalkyl)2, -N(aryl)2, - N(heteroaryl)2, -N(heterocyclyl)2, -N(Ci-9 alkyl)(C3_i5 cycloalkyl), -N(Ci-9 alkyl)(C2_6 alkenyl), -N(C1-9 alkyl)(C2_6 alkynyl), -N(C1-9 alkyl)(C3_i5 cycloalkyl), -N(C1-9 alkyl)(C1-8 haloalkyl), -N(C1-9 alkyl)(aryl), -N(C1-9 alkyl)(heteroaryl), -N(C1-9
alkyl)(heterocyclyl), -C(0)(C1-9 alkyl), -C(0)(C2_6 alkenyl), -C(0)(C2_6
alkynyl), -C(0)(C3-15 cycloalkyl), -C(0)(C1-8 haloalkyl), -C(0)(aryl), -C(0)(heteroaryl), -C(0)(heterocyclyl), -C(0)0(C1-9 alkyl), -C(0)0(C2_6 alkenyl), -C(0)0(C2_6
alkynyl), -C(0)0(C3_i5 cycloalkyl), -C(0)0(C1-8 haloalkyl), -C(0)0(aryl), - C(0)0(heteroaryl), -C(0)0(heterocyclyl), -C(0)NH2, -C(0)NH(Ci_9
alkyl), -C(0)NH(C2_6 alkenyl), -C(0)NH(C2_6 alkynyl), -C(0)NH(C3_i5
cycloalkyl), -C(0)NH(Ci_8 haloalkyl), -C(0)NH(aryl), -C(0)NH(heteroaryl), - C(0)NH(heterocyclyl), -C(0)N(C1-9 alkyl)2, -C(0)N(C3_i5 cycloalkyl)2, -C(0)N(C2_6 alkenyl)2, -C(0)N(C2.6 alkynyl)2, -C(0)N(C3_15 cycloalkyl),, -C(0)N(C1.8 haloalkyl)2, - C(0)N(aryl)2, -C(0)N(heteroaryl)2, -C(0)N(heterocyclyl)2, -NHC(0)(Ci_9
alkyl), -NHC(0)(C2_6 alkenyl), -NHC(0)(C2_6 alkynyl), -NHC(0)(C3_i5
cycloalkyl), -NHC(0)(d_8 haloalkyl), -NHC(0)(aryl), -NHC(0)(heteroaryl), - NHC(0)(heterocyclyl), -NHC(0)0(Ci_9 alkyl), -NHC(0)0(C2_6 alkenyl), -NHC(0)0(C2_ 6 alkynyl), -NHC(0)0(C3_i5 cycloalkyl), -NHC(0)0(Ci_8 haloalkyl), -NHC(0)0(aryl), - NHC(0)0(heteroaryl), -NHC(0)0(heterocyclyl), -NHC(0)NH(Ci_9
alkyl), -NHC(0)NH(C2_6 alkenyl), -NHC(0)NH(C2_6 alkynyl), -NHC(0)NH(C3_i5 cycloalkyl), -NHC(0)NH(Ci_8 haloalkyl), -NHC(0)NH(aryl), - NHC(0)NH(heteroaryl), -NHC(0)NH(heterocyclyl), -SH, -S(C1-9 alkyl), -S(C2_6 alkenyl), -S(C2_6 alkynyl), -S(C3_i5 cycloalkyl), -S(C1-8 haloalkyl), -S(aryl), - S(heteroaryl), -S(heterocyclyl), -NHS(0)(Ci_9 alkyl), -N(C1-9 alkyl)(S(0)(C1-9 alkyl), - S(0)N(d_9 alkyl)2, -S(0)(d_9 alkyl), -S(0)(NH)(d_9 alkyl), -S(0)(C2_6
alkenyl), -S(0)(C2_6 alkynyl), -S(0)(C3-15 cycloalkyl), -S(0)(C1-8 haloalkyl), -S(0)(aryl), -S(0)(heteroaryl), -S(0)(heterocyclyl), -S(0)2(C1-9 alkyl), -S(0)2(C2_6
alkenyl), -S(0)2(C2_6 alkynyl), -S(0)2(C3_15 cycloalkyl), -S(0)2(d_8 haloalkyl), - S(0)2(aryl), -S(0)2(heteroaryl), -S(0)2(heterocyclyl), -S(0)2NH(Ci_9 alkyl),
or -S(0)2N(d_9 alkyl)2;
wherein any alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with one or more halo, Ci-9 alkyl, Ci-8 haloalkyl, -OH, -NH2, -NH(Ci-9 alkyl), -NH(C3_i5 cycloalkyl), -NH(d_8 haloalkyl), -NH(aryl), -NH(heteroaryl), -NH(heterocyclyl), -N(d_9 alkyl)2, -N(C3-15 cycloalkyl)2, -NHC(0)(C3-15 cycloalkyl), -NHC(0)(Ci_8 haloalkyl), - NHC(0)(aryl), -NHC(0)(heteroaryl), -NHC(0)(heterocyclyl), -NHC(0)0(d_9 alkyl), -NHC(0)0(C2-6 alkynyl), -NHC(0)0(C3-i5 cycloalkyl), -NHC(0)0(Ci_8 haloalkyl), -NHC(0)0(aryl), -NHC(0)0(heteroaryl), -NHC(0)0(heterocyclyl), - NHC(0)NH(d_9 alkyl), -S(0)(NH)(Ci-9 alkyl), S(0)2(d_9 alkyl), -S(0)2(C3-15 cycloalkyl), -S(0)2(C1-8 haloalkyl), -S(0)2(aryl), -S(0)2(heteroaryl), - S(0)2(heterocyclyl), -S(0)2NH(d_9 alkyl), -S(0)2N(d_9 alkyl)2, -0(C3-i5
cycloalkyl), -0(Ci_8 haloalkyl), -O(aryl), -0(he ternary 1), -O(heterocyclyl), or -0(Ci_9 alkyl); and
with the proviso that when R1 is C3 alkyl, R2 is C5 alkyl substituted with F and hydroxyl, R3, R5, R6, R7 are H, and R4 is CN, then R1 is substituted with Z1;
or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof.
2. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is Ci-10 alkyl optionally substituted with Z1, with the proviso that when R1 is C3 alkyl, R2 is C5 alkyl substituted with F and hydroxyl, R3, R5, R6, R7 are H, and R4 is CN, then R1 is substituted with Z1.
3. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R1 is methyl.
4. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R1 is C6-io alkyl optionally substituted with Z1.
5. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof , wherein:
R1 is Ci-5 alkyl substituted with one or more substituents selected from -CI, oxo, -CN, C2-6 alkenyl, C2_6 alkynyl, cyclopropyl, naphthyl, heteroaryl, nitrogen or sulfur containing monocyclic heterocyclyl, bicyclic heterocyclyl, C7-i5 cycloalkyl, -O-R9, - C(0)-R , -C(0)0-R , -C(0)-N(R1Z)( R1Z), -N(R1Z)( R1Z), -N(R1Z)2(R ) , -N(R1Z)C(0 R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), - NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
R9 at each occurrence is independently C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, Ci_6 haloalkyl, C3-15 cycloalkyl, aryl, heterocyclyl, or heteroaryl;
wherein each C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, Ci_6 haloalkyl, C3-15 cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with Zla;
wherein said Ci-5 alkyl is also optionally substituted with Z1 ; and
wherein each said C2_6 alkenyl, C2_6 alkynyl, cyclopropyl, naphthyl, heteroaryl, nitrogen or sulfur containing monocyclic heterocyclyl, bicyclic heterocyclyl, or C7-i5 cycloalkyl is optionally substituted with Zla.
6. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is Ci-5 alkyl optionally substituted with Z1 ;
wherein said Ci-5 alkyl is substituted with one or more C4_6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or phenyl;
wherein said C4_6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or phenyl is optionally substituted with Zla;
wherein said C4_6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or phenyl is substituted by one or more halo, oxo, -CN, C2_6 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-7 cycloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)-R12, -C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, - N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and wherein said C2_6 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3_7 cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
7. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein: R1 is Ci-5 alkyl optionally substituted with F or -OH and substituted with one or more substituents selected from C4_6 cycloalkyl, oxetanyl, tetrahydrofuranyl,
tetrahydropyranyl, or phenyl; wherein said C4_6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or phenyl is substituted with two or more substituents selected from - OH and -C¾ and optionally substituted with Zla.
8. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R1 is C3-10 cycloalkyl optionally substituted with Z1.
9. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is C7-10 cycloalkyl optionally substituted with Z1, wherein when said C7-C10 cycloalkyl is bicyclo[2.2.1]heptanyl, then said C7-10 cycloalkyl is substituted with at least one of oxo, -CI, -NO2, -CN, -N3, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C7-i5 cycloalkyl, C5-8 haloalkyl, aryl, pyrazolyl, -O-R9, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), - N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, or -S(0)2N(R12)( R12).
10. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is C3-6 cycloalkyl substituted with one or more -O-R16;
wherein said C3-6 cycloalkyl is optionally substituted with Z1;
R16 at each occurrence is independently Cs_g alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci_6 haloalkyl, C3-15 cycloalkyl, aryl, heterocyclyl, or heteroaryl;
wherein each C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, Ci_6 haloalkyl, C3-15 cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with Zla.
11. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is C3-6 cycloalkyl substituted with one or more -C(0)-Rn; wherein said C3-6 cycloalkyl is optionally substituted with Z1 ;
wherein R11 at each occurrence is independently Ci_g alkyl, C2-6 alkenyl, C2-6 alkynyl, C3_ ucycloalkyl, aryl, heterocyclyl, or heteroaryl,
wherein each C1-9 alkyl is optionally substituted with -NO2, -N3, -CN, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, C4_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(O)- R12, -C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0
R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), - NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein each said C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heterocyclyl, or heteroaryl is optionally substituted with Zla.
12. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is C3-6 cycloalkyl substituted with one or more oxo, C5-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, heterocyclyl, -C(0)0-R12, -C(0)-N(R9)(R9), - C(0)N(H)(C4_9 alkyl), -C(O)N(H)(C3-10 cycloalkyl), -C(0)N(H)( heterocyclyl), - C(0)N(H)(aryl), -C(0)N(H)(heteroaryl), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0 R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), - NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein said C5-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, heterocyclyl, -C(0)N(H)(C4_9 alkyl), -C(O)N(H (C3-10 cycloalkyl), -C(0)N(H)( heterocyclyl), -C(0)N(H)(aryl), or -C(0)N(H)(heteroaryl) is optionally substituted with Zla; and wherein said C3-6 cycloalkyl is optionally substituted with Z1 ;
wherein when C3-6 cycloalkyl is bicyclo[l. l. l]pentanyl; then said bicyclo[l. l . l]pentanyl is substituted with one or more oxo, -NO2, -N3, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C7_ 15 cycloalkyl, C5-8 haloalkyl, aryl, pyrazolyl, -O-R16, -C(0)Rn, -C(0)0- R12, -C(0)N(R9)(R9), -C(0)N(H)(C4 alkyl), -C(0)N(H)(R16), -N(R12)( R12), - N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR , -OC(0)-N(Rlz)( R1Z), -Si(Rlz)3, -S-R , -S(0)R1Z, -S(0)(NH)R1Z, or -S(0)2N(R12)( R12).
13. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein
R1 is C3-6 cycloalkyl substituted with C4 alkyl, wherein said C4 alkyl is optionally substituted with halo, -NO2, -CN, -N3, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)-R12, -C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said C2-6 alkenyl, C2-6 alkynyl, C3_i5 cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla; and
wherein said C3-6 cycloalkyl is optionally substituted with Z1 ;
wherein when said C3_6 cycloalkyl is bicyclo[l.l.l]pentanyl substituted with C4 alkyl then said C4 alkyl is further substituted with oxo, -NO2, -N3, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C7-15 cycloalkyl, C5-8 haloalkyl, aryl, heteroaryl, -O-R9, -C(0)R12, -C(0)0- R12, -C(0)N(R12)(R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, or -S(0)2N(R12)( R12).
14. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein
R1 is C3-6 cycloalkyl optionally substituted with Z1; and
wherein said C3-6 cycloalkyl is substituted with four or more substituents selected from the group consisting of F, -OH, -CI, -CN, C1-3 alkyl, C1-3 fluoroalkyl, Ci_4 hydroxyalkyl, Ci_4 alkoxy, -C(0)NH2, -C(0)NH(Ci_3 alkyl); and -C(0)(Ci_3 fluoroalkyl).
15. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is C3-6 cycloalkyl substituted with C1-3 fluoroalkyl, or -C(0)(Ci_3 fluoroalkyl) wherein said C3-6 cycloalkyl is also optionally substituted with Z1; wherein said C1-3 fluoroalkyl or -C(0)(Ci_3 fluoroalkyl) is further substituted with at least one oxo, -CI, -NO2, -CN, -N3, C3_g alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-is cycloalkyl, C3-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein said C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-i5 cycloalkyl, C3-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zlb.
16. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is C3-6 cycloalkyl substituted with at least one Ci-3 alkyl or C1-4 hydroxyalkyl wherein said C3-6 cycloalkyl is optionally substituted with Z1;
wherein said Ci_3 alkyl or Ci_4 hydroxyalkyl is further substituted with oxo, chloro, -NO2, -CN, -N3, C4-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein said C4_9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zlb .
17. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R1 is C3_6 cycloalkyl substituted with at least one C alkoxy or C(0)NH(Ci_3 alkyl); wherein said C3-6 cycloalkyl is optionally substituted with Z1 and wherein said Ci_4 alkoxy or C(0)NH(Ci_3 alkyl) is further substituted with oxo, halo, -N02, -CN, -N3, C4_9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), - N(R1Z)2(R ) , -N(R1Z)-C(0)R , -N(R1Z)C(0)0(R1Z), -N(R1Z)C(0)N(R1Z)( R1Z), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said C4-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zlb.
18. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R1 is 5-10 membered heteroaryl optionally substituted with Z1.
19. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R1 is imidazolyl, triazolyl, oxazolyl, isoxazolyl, pyridinyl, thiadiazole, oxadiazole, pyrimidinyl, pyridizinyl, pyrazinyl, isothiazolyl, tetrazolyl, thiophenyl, furanyl, triazinyl, or 8-10 membered heteroaryl optionally substituted with Z1.
20. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R1 is a 6 membered heteroaryl optionally substituted with Z1.
21. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R1 is 4-7 membered monocyclic heterocyclyl optionally substituted with Z1.
22. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R1 is azetidinyl, morpholinyl, thiomorpholinyl, 4-7 membered sultam, 4-7 membered cyclic carbamate, 4- 7 membered cyclic carbonate, or 4-7 membered cyclic sulfide optionally substituted with Z1.
23. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein: R1 is 6-12 membered bicyclic heterocyclyl optionally substituted with Z1;
wherein when said 6-12 membered bicyclic heterocyclyl is 4,5,6,7- tetrahydropyrazolo[l,5-a]pyrazinyl then said 6-12 membered bicyclic heterocyclyl is substituted with at least one oxo, C3-6 cycloalkyl, or C(0)(Ci_5 alkyl).
24. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl;
wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl or thiazolyl, is substituted with one or more substituents selected from -CI, oxo, -CN, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C7-10 cycloalkyl, aryl, pyridinyl, pyridizinyl, 5-10 membered bicyclic heteroaryl, 5-membered heteroaryl, nitrogen or sulfur containing monocyclic heterocyclyl, bicyclic heterocyclyl, -O-R9, -C(0)-Rn, - C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)- R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), - NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, - S-R12, -S(0)R12, -S(0)(NH)R12, or -S(0)2N(R12)( R12);
wherein said C5-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C7-10 cycloalkyl, aryl, pyridinyl, pyridizinyl, 5-10 membered bicyclic heteroaryl, 5-membered heteroaryl, nitrogen or sulfur containing monocyclic heterocyclyl or bicyclic heterocyclyl is optionally substituted with Zla;
wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, thiazolyl, is optionally substituted with Z1.
25. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl;
wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl, is optionally substituted with Z1;
wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, thiazolyl, is substituted with 3 or more substituents selected from F, -OH, C1-4 alkyl, Ci_3 hydroxyalkyl, Ci_4 fluoroalkyl,
Figure imgf000495_0001
alkyl), -C(0)(Ci_3 fluoroalkyl), -S(0)2(Ci_3 alkyl), C3-6 cycloalkyl, C3-6 fluorocycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrimidinyl, fluoropyrimidinyl, or methoxyprimidinyl.
26. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein
R1 is pyrrolidinyl, piperidinyl, pyrazolyl or thiazolyl; wherein said pyrrolidinyl, piperidinyl, pyrazolyl or thiazolyl is optionally substituted with Z1; wherein said pyrrolidinyl, piperidinyl, pyrazolyl or thiazolyl is substituted with one or more substituents independently selected from -(Ο¾)ι-30( ι-3 alkyl), -S(0)2(Ci_3 alkyl), oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, or 0¾(¾-6 cycloalkyl); and wherein said -(CH2)i-30(Ci_3 alkyl), -S(0)2(Ci_3 alkyl), oxetanyl, tetrahydrofuranyl, tetrahydropyranyl or 0¾(¾-6 cycloalkyl) are independently substituted with one or more oxo, halo, -NO2, -CN, -N3, C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein said C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
27. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl; wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl is optionally substituted with a -F or -OH and is substituted with one or more substituents independently selected from C1-4 alkyl or C1-3 hydroxy alkyl;
wherein said C1-4 alkyl or C1-3 hydroxyalkyl is substituted with one or more oxo, -CI, - NO2, -CN, -N3, C4-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C7-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -0-Rlb, -C(0)R , -C(0)0-
R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -
N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2-
N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)-
N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein any alkyl, hydroxyalkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zlb.
28. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl;
wherein said oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, pyrrolidinyl, piperidinyl, pyrazolyl, or thiazolyl is optionally substituted with a -F or -OH and is substituted with one or more substituents independently selected from Ci_4 fluoroalkyl, -C(0)(Ci_3 fluoroalkyl), C3-6 cycloalkyl, C3-6 fluorocycloalkyl, and fluoropyrimidinyl;
wherein said Ci_4 fluoroalkyl, -C(0)(Ci_3 fluoroalkyl), C3-6 cycloalkyl, C3-6
fluorocycloalkyl or fluoropyrimidyl is substituted with one or more oxo, -CI, -N02, -CN, -N3, C4_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zlb .
29. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R1 is C6-io aryl optionally substituted with Z1.
30. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein: R1 is C6-io aryl is substituted with one or more Ci_6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)Rn, -C(0)0-R12, -C(0)NH(C3-6 cycloalkyl), -C(0)NH(C4-6 alkyl), -C(0)heterocyclyl, N(R12)( R12), - N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said Ci_6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, heterocyclyl, -C(0)NH(C3-6 cycloalkyl), -C(0)NH(C4-6 alkyl),or -C(0)heterocyclyl is optionally substituted with Zla;
wherein said C6-io aryl is optionally substituted with Z1.
31. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is C6-io aryl substituted with one or more -C(0)NH(Ci_3 alkyl) and optionally substituted with Zla;
wherein said -C(0)NH(Ci_3 alkyl) is substituted with one or more oxo, halo, -NO2, -CN, -N3, C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
32. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R1 is C6-io aryl substituted with one or more -C(0)(Ci_3 fluoroalkyl);
wherein said -C(0)(Ci_3 fluoroalkyl) is substituted with one or more oxo, -CI, -NO2, - CN, -N3, C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, C3-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR , -OC(0)-N(Rlz)( R1Z), -Si(Rlz)3, -S-R , -S(0)R1Z, -S(0)(NH)R1Z, -S(0)2R or -S(0)2N(R12)( R12);
wherein said C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, C3-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb; and wherein said C6-io aryl is optionally substituted with Z1.
33. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R1 is -N(R12)( R12), - S(0)2R12, -S(0)2N(R12)( R12), or -H.
34. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R2 is Ci_io alkyl optionally substituted with Z1.
35. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R2 is Ci_io alkyl.
36. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R2 is C7-10 alkyl, optionally substituted with Z1.
37. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is Ci_6 alkyl substituted with one or more -0(Ci_2 alkyl), -NHC(0)(Ci_3 alkyl), or - S(0)2(C!_3 alkyl);
wherein said -0(Ci_2 alkyl) is substituted with one or more oxo, -CI, -N02, -CN, -N3, C2_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-is cycloalkyl, C2_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), - N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR , -OC(0)-N(Rlz)( R1Z), -Si(Rlz)3, -S-R , -S(0)R1Z, -S(0)(NH)R1Z, -S(0)2R or -S(0)2N(R12)( R12); and said -0(Ci_2 alkyl) is optionally substituted with -F;
wherein said -NHC(0)(Ci_3 alkyl), or -S(0)2(Ci_3 alkyl) is substituted with one or more oxo, halo, -NO2, -CN, -N3, C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), - N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), - N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, - S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said Ci_6 alkyl is optionally substituted with Zla; and
wherein each said C2-9 alkyl, C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, C2-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
38. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is C4-6 alkyl substituted with one or more substituents selected from -CI, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, monocyclic heterocyclyl, bicyclic heterocyclyl, -( C3-9 alkyl), -C C3-10 cycloalkyl), -O(heterocyclyl), -O(aryl), - O(heteroaryl), -C(0)-R12, -C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), - N(R12)2(R12)+, -N(R12)C(0)(C4-9 alkyl), -N(R12)C(0)(C3-io cycloalkyl), - N(R12)C(0)(heterocyclyl), -N(R12)C(0)(aryl), -N(R12)C(0)( heteroaryl), -N(R12)C(0)0- R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2(C4_9 alkyl), -S(0)2(aryl), -S(0)2(C3-1o cycloalkyl), - S(0)2(heterocyclyl), - S(0)2(heteroaryl), or -S(0)2N(R12)( R12);
wherein said C4_6 alkyl is also optionally substituted with Z1; and
wherein said C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl, monocyclic heterocyclyl, bicyclic heterocyclyl, -CXC3-9 alkyl), -C C3-10 cycloalkyl), -O(heterocyclyl), -O(aryl), -O(heteroaryl), -N(R12)C(0)(C4_9 alkyl), -N(R12)C(0)(C3-io cycloalkyl), - N(R12)C(0)( heterocyclyl), -N(R12)C(0)(aryl), -N(R12)C(0)( heteroaryl), -S(0)2(C4_9 alkyl), -S(0)2(aryl), -S(0)2(C3-1o cycloalkyl), -S(0)2(heterocyclyl), - S(0)2(heteroaryl), - NHC(0)(Ci_3 alkyl), or -S(0)2(Ci_3 alkyl) is optionally substituted with Zla.
39. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is C4_6 alkyl substituted with one or more -0(CH2)2R17 or -0(CH2)R17;
R17 at each occurrence is independently C3-15 cycloalkyl, aryl, heterocyclyl, heteroaryl, - O-R12, -C(0)-R12, -C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), - N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12
or -S(0)2N(R12)( R12);
wherein saidC3_i5 cycloalkyl, aryl, heterocyclyl, and heteroaryl optionally is substituted with Zlb; and
wherein said C4_6 alkyl is also optionally substituted with Z1.
40. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is C4_6 alkyl substituted with five or more substituents selected from F, hydroxyl, -CN, -OCH3, -OCD3, -NHC(0)(Ci_3 alkyl), -S(0)2(C1-3 alkyl), or Ci_2 fluoroalkoxy; and wherein said C4_6 alkyl is optionally substituted with Z1.
41. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is Ci_3 alkyl substituted with one or more substituents selected from -CI, C2_6 alkenyl, C2_6 alkynyl, cyclopropyl, napthyl, bicyclic heterocyclyl, C7-i5 cycloalkyl, -0(CH2)2R17, - 0(CH2)R17, -0(C3-9 alkyl), -O(C3-10 cycloalkyl), -O(heterocyclyl), -O(aryl), - O(heteroaryl), -C(0)(C1-9 alkyl), -C(0)(cyclopropyl), -C(0)0-R12, -C(0)-N(R12)( R12), - N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)(C4_9 alkyl), -N(R12)C(0)(C3-io cycloalkyl), - N(R12)C(0)(heterocyclyl), -N(R12)C(0)(aryl), -N(R12)C(0)( heteroaryl), -N(R12)C(0)0- R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2(C4_9 alkyl), -S(0)2(aryl), -S(0)2(C3-io cycloalkyl), - S(0)2(heterocyclyl), - S(0)2(heteroaryl), or -S(0)2N(R9)(R12);
wherein said Ci-3 alkyl is also optionally substituted with Z1; and wherein said C2-6 alkenyl, C2-6 alkynyl, cyclopropyl, napthyl, bicyclic heterocyclyl,C7_i5 cycloalkyl , -0(¾_9 alkyl), -0(C3_io cycloalkyl), -O(heterocyclyl), -O(aryl), - O(heteroaryl), -N(R12)C(0)(C4_9 alkyl), -N(R12)C(0)(C3-io cycloalkyl), -N(R12)C(0)( heterocyclyl), -N(R12)C(0)(aryl), -N(R12)C(0)(heteroaryl), -S(0)2(C4_9 alkyl), - S(0)2(aryl), -S(0)2(C3-1o cycloalkyl), -S(0)2(heterocyclyl), or - S(0)2(heteroaryl) is optionally substituted with Zla.
42. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is Ci-3 alkyl substituted with one or more substituents selected from azetidinyl, tetrahydrofuranyl, triazolyl, oxazolyl, isoxazolyl, thiadiazole, oxadiazole, pyrimidinyl, pyridizinyl, pyrazinyl, isothiazolyl, tetrazolyl, furanyl, thiomorpholinyl, 4-7 membered sultam, 4-7 membered cyclic carbamate, 4-7 membered cyclic carbonate, 4-7 membered cyclic sulfide, or 8-10 membered heteroaryl; any of which is optionally substituted with Zla; and
wherein said Ci_3 alkyl is also optionally substituted with Z1.
43. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is Ci-3 alkyl substituted with one substituent selected from phenyl, oxetanyl, tetrahydropyranyl, morpholinyl, piperidinyl, imidazolyl, pyridinyl, thiophenyl, or C4_6 cycloalkyl;
wherein said phenyl, oxetanyl, tetrahydropyranyl, morpholinyl, piperidinyl, imidazolyl, pyridinyl, thiophenyl, or C4_6 cycloalkyl is substituted with one or more oxo, -N02, -N3, - CN, C4_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -0(C3_6 alkyl), -0(C3_6 cycloalkyl), -O(heterocyclyl), -C(0)-R12, - C(0)0-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)- R12, -N(R12)C(0)0-R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), - NR12S(0)2N(R12)( R12), -NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, - S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R9)(R12); and
wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zla.
44. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is Ci-3 alkyl optionally substituted with Z1 and is substituted with one substituent selected from phenyl, oxetanyl, tetrahydropyranyl, morpholinyl, piperidinyl, imidazolyl, pyridinyl, thiophenyl, or C4_6 cycloalkyl;
wherein said phenyl, oxetanyl, tetrahydropyranyl, morpholinyl, piperidinyl, imidazolyl, pyridinyl, thiophenyl, or C4_6 cycloalkyl is substituted with four or more substituents selected from -F, -CI, -OH, Ci_3 alkyl, -0(Ci_2 alkyl) or -S(0)2NH2.
45. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is Ci-3 alkyl substituted with oxo and optionally substituted with one or more substituents selected from halo, azetidinyl, pyrrolidinyl, piperazinyl, tetrahydrofuranyl, thiomorpholinyl, -CN, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, cyclopropyl, C7-i5 cycloalkyl, Ci_8 haloalkyl, -O-R12, -C(0)-R12, -C(0)0-R12, -C(0)-N(R12)( R12), - N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, - N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2R12or -S(0)2N(R9)(R12); and
wherein said C1-3 alkyl is optionally substituted with Z1 ;
wherein said, C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, cyclopropyl, C7-i5 cycloalkyl, Ci-8 haloalkyl, azetidinyl, pyrrolidinyl, piperazinyl, tetrahydrofuranyl, or thiomorpholinyl is optionally substituted with Zla .
46. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R2 is C3 alkyl substituted with five or more substituents selected from -F, -OH, -OCH3, -
CN, -NHC(0)(Ci_3 alkyl), Ci_2 fluoroalkoxy, or -S(0)2(C1-3 alkyl).
47. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R2 is C3-10 cycloalkyl optionally substituted with Z1.
48. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R2 is cyclopropyl optionally substituted with Z1.
49. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R2 is C7-io cycloalkyl optionally substituted with Z1.
50. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is C4-6 cycloalkyl substituted with one or more substituents selected from -halo, oxo, - CN, Ci-4 alkyl, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -( C4-9 alkyl), -0(C3_io cycloalkyl), -O(heterocyclyl), -O(aryl), -O(heteroaryl), -N(R12)C(0)(C5-9 alkyl), -N(R12)C(0)(C3-io cycloalkyl), - N(R12)C(0)(heterocyclyl), -N(R12)C(0)(aryl), -N(R12)C(0)(heteroaryl), -NH(R12), - N(R12)(C4-9 alkyl), -N(R12)(C3-io cycloalkyl), -N(R12)(heterocyclyl), -N(R12)(aryl), - N(R12)(heteroaryl), -N(R12)C(0)0(C4-9 alkyl), -N(R12)C(0)0(C3-io cycloalkyl), - N(R12)C(0)0( heterocyclyl), -N(R12)C(0)0(aryl), -N(R12)C(0)0(heteroaryl), - C(0)N(R12)(C5-9 alkyl), -C(0)N(R12)(C7-io cycloalkyl), -C(0)N(R12)(heterocyclyl), - C(0)N(R12)(aryl), -C(0)N(R12)(heteroaryl), -C(0)N(R9)(R9), -C(0)0-R12, - N(R12)2(R12)+, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - N(R12)S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)2R12, -S(0)(NH)R12, or -S(0)2N(R12)( R12);
wherein said C4-6 cycloalkyl is also optionally substituted with Z1;
wherein said C1-4 alkyl is optionally substituted with oxo, halo, -N02, -CN, -N3, C4-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3_u cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R16, -0(C4-9 alkyl), -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(0)-N(R12)( R12 R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and wherein each said C5-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3_i5 cycloalkyl, Ci-8 haloalkyl, - ( C4-9 alkyl), -0(C3_io cycloalkyl), -O(heterocyclyl), -O(aryl), -O(heteroaryl), - N(R12)C(0)(C5-9 alkyl), -N(R12)C(0)(C3_io cycloalkyl), -N(R12)C(0)(heterocyclyl), - N(Rlz)C(0)(aryl), -N(Rlz)C(0)(heteroaryl), -N(R1Z)(C4_9 alkyl), -N(Rlz)(C3_io cycloalkyl), -N(R12)(heterocyclyl), -N(R12)(aryl), -N(R12)(heteroaryl), -N(R12)C(0)0(C4_9 alkyl), -N(R12)C(0)0(C3-io cycloalkyl), -N(R12)C(0)0(heterocyclyl), - N(R12)C(0)0(aryl), -N(R12)C(0)0(heteroaryl), -C(0)N(R12)(C5-9 alkyl), - C(0)N(R12)(C7-io cycloalkyl), -C(0)N(R12)(heterocyclyl), -C(0)N(R12)(aryl), - C(0)N(R12)(heteroaryl), aryl, heteroaryl, or heterocyclyl is optionally substituted with
51. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is C4_6 cycloalkyl substituted with one or more substituents selected from Ci_4 hydroxyalkyl, Ci_3 alkoxy, -(CH2)i-30(Ci_3 alkyl), -C(0)NH(Ci_4 alkyl), -C(0)NH(C3_6 cycloalkyl), -N(C1-3 alkyl)2, -NHC(0)0(d_3 alkyl), -NHC(0)(CM hydroxyalkyl);
wherein said C4_6 cycloalkyl is optionally substituted with Z1;
wherein said -C(0)NH(C3_6 cycloalkyl) is substituted with Zla;
wherein said Ci_4 hydroxyalkyl or -NHC(0)(Ci_4 hydroxyalkyl) is substituted with oxo, halo, -NO2, -CN, -N3, C4_9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3_i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), - N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), - N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, - S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said Ci_3 alkoxy, -(CH2)i-30(Ci_3 alkyl), -N(C1-3 alkyl)2, -NHC(0)0(Ci_3 alkyl) is substituted with oxo, halo, -NO2, -CN, -N3, C3_9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3_i5 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S- R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said -C(0)NH(Ci_4 alkyl) is substituted with oxo, halo, -NO2, -CN, -N3, C4_9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3_i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), - N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR , -OC(0)-N(Rlz)( R1Z), -Si(Rlz)3, -S-R , -S(0)R1Z, -S(0)(NH)R1Z, -S(0)2R or -S(0)2N(R12)( R12); and
wherein each said C3-9 alkyl, C4-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
52. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is C4-6 cycloalkyl substituted with one or more -NHC(0)(Ci_3 alkyl);
wherein at least one -NHC(0)(Ci_3 alkyl) is substituted with one or more oxo, halo, -
N02, -CN, -N3, C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0-
R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -
N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2-
N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)-
N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein said C4_6 cycloalkyl is optionally substituted with Z1; and
wherein said C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla.
53. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is C4-6 cycloalkyl substituted with three or more substituents selected from -OH, Ci_4 hydroxyalkyl, Ci_3 alkoxy, -(CH^OCC^ alkyl), -C(0)NH(Ci_4 alkyl), -C(0)NH(C3-6 cycloalkyl), -N(C1-3 alkyl)2, -NHC(0)(Ci_3 alkyl), -NHC(0)0(Ci_3 alkyl), or - NHC(0)(Ci_4 hydroxyalkyl);
wherein said C4_6 cycloalkyl is optionally substituted with Z1.
54. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R2 is s 5- 10 membered heteroaryl optionally substituted with Z1.
55. The compound of Claims 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R2 is oxazolyl, isoxazolyl, thiadiazole, thiazole, oxadiazole, isothiazolyl, tetrazolyl, thiophenyl, furanyl, or a 6-10 membered heteroaryl; any of which is optionally substituted with Z1;
56. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R2 is 4-7 membered monocyclic heterocyclyl optionally substituted with Z1.
57. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R2 is azetidinyl, oxetanyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, 4-7 membereded sultam, 4-7 membered cyclic carbamate, 4-7 membered cyclic carbonate, or 4-7 membered cyclic sulfide; any of which is optionally substituted with Z1.
58. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl;
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more substituents selected from oxo, halo, -CN, C2-4 alkyl, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_ 8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)-R12, -C(0)0-R12, -C(O)- N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, - N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)2(C4-9 alkyl), -S(0)2(C3-1o cycloalkyl), -S(0)2(heterocyclyl), -S(0)2(aryl), - S(0)2(heteroaryl), -S(0)(NH)R12,or -S(0)2N(R12)( R12);
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is optionally substituted with Zla;
wherein said C2_4 alkyl is optionally substituted with halo, -N02, -CN, -N3, alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl,
heterocyclyl, -O-R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), - N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR , -OC(0)-N(Rlz)( R1Z), -Si(Rlz)3, -S-R , -S(0)R1Z, -S(0)(NH)R1Z, -S(0)2R or -S(0)2N(R12)( R12); and
wherein each said C3-9 alkyl, C5-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -S(0)2(C4_9 alkyl), -S(0)2(C3_io cycloalkyl), - S(0)2(heterocyclyl), -S(0)2(aryl), or -S(0)2(heteroaryl) is optionally substituted with Zla.
59. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl;
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more Ci alkyl;
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is optionally substituted with Z1;
wherein said Ci alkyl is optionally substituted with oxo, halo, -NO2, -CN, -N3, C2-6 alkenyl, C2-6 alkynyl, C3-is cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-
R9, -C(0)R12, -C(0)0-R12, -C(0)N(R9)( R9), - C(0)N(R12)(C4_9 alkyl), - C(0)N(R12)(C3-
10 cycloalkyl), - C(0)N(R12)(heterocyclyl), - C(0)N(R12)(aryl), -
C(0)N(R12)(heteroaryl), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, -
N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2-
N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)-
N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein said C2-6 alkenyl, C2-6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, - C(0)N(R12)(C3-io cycloalkyl), - C(0)N(R12)(heterocyclyl), - C(0)N(R12)(aryl), - C(0)N(R12)(heteroaryl) is optionally substituted with Zla.
60. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl; any of which is optionally substituted with Z1;
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more S(0)2(Ci_3 alkyl); wherein said S(0)2(Ci_3 alkyl) is substituted with oxo, halo, -NO2, -CN, -N3, C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3_i5 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl,
heterocyclyl, -O-R12, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), - N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein said C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
61. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl; any of which is optionally substituted with Z1;
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more Ci_4 hydroxyalkyl; wherein said Ci_4 hydroxyalkyl is substituted with oxo, halo, -NO2, -CN, -N3, C4_9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl,
heterocyclyl, -O-R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), - N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein said C4_9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
62. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl; any of which is optionally substituted with Z1;
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more -CH2C(0)NH(Ci_6 alkyl); wherein said -CH2C(0)NH(Ci_6 alkyl) is substituted with oxo, -CI, -N02, -CN, -N3, C6-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3_i5 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), - N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said -CH2C(0)NH(Ci_6 alkyl) is optionally substituted with Zla; and wherein said C6-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3 5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zlb.
63. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl;
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is substituted with one or more -CH2C(0)NH(C4_6 alkyl); and
wherein said tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl pyrrolyl, pyrazolyl, imidazolyl, or triazolyl is optionally substituted with Z1.
64. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R2 is C6-io aryl optionally substituted with Z1.
65. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R2 is 6-12 membered bicyclic heterocyclyl optionally substituted with Z1 ;
wherein when said 6-12 membered bicyclic heterocyclyl is l-oxa-7- azaspiro[3.5]nonanyl, then said l-oxa-7-azaspiro[3.5]nonanyl is substituted with one or more Z1.
66. The compound of Claims 1-33, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R2 is - N(R12)( R12), -S(0)2R12, -S(0)2N(R12)( R12); or -H.
67. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R3 is selected from H, halo, -N02, -CN, -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)S(0)2(R12), -N(R12)C(0)-N(R12)( R12), -S(0)2R12 ), -SR12 and -S(0)2N(R12)( R12).
68. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R3 is selected from -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R9)( R9), -
NH(R9), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)S(0)2(R12), -N(R12)C(0)-N(R12)( R12), -S(0)2(R12 ), -S-R12 or -S(0)2N(R12)( R12);
wherein when said -N(H)(R9) is NH(C1-3 alkyl), -N(H)(R9) is NH(d_4 hydroxy alkyl), or -O-R12 is -0(Ci_3 alkyl), then said NH(Ci_3 alkyl), NH(Ci_4 hydroxy alkyl), or -0(Ci_3 alkyl) is further substituted with one or more oxo, halo, -N02, -CN, -N3, C4_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)- C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein said C4_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla.
69. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R3 is selected from -0(C4 alkyl) or -N(H)(C4 alkyl); wherein said -0(C4 alkyl) is optionally substituted with Zla; wherein said -N(H)(C4 alkyl) is optionally substituted with oxo, halo, -N02, -CN, -N3, C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-i5 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0-
R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R1Z)C(0)0(R1Z), -N(R1Z)C(0)N(R1Z)( R1Z), -N(R1Z)S(0)2(R ), -N(R1Z)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein said C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla.
70. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R3 is C1-9 alkyl optionally substituted with Z1.
71. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R3 is Ci_2 alkyl optionally substituted with F and further substituted with one or more oxo, -CI, -N02, -N3, -CN, C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)-R12, -C(0)0-R12, -C(0
N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, - N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2R12or -S(0)2N(R12)( R12); and
wherein said C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3 5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla.
72. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R3 is C3 alkyl substituted with one or more Z1.
73. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R3 is C4-9 alkyl optionally substituted with Z1.
74. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R3 is C2_9 alkynyl optionally substituted with Z1.
75. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R3 is C2-9 alkenyl optionally substituted with Z1.
76. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R3 is a 5- 10 membered heteroaryl optionally substituted with Z1.
77. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R3 is a 5-10 membered heteroaryl optionally substituted with Z1;
wherein if said 5-10 membered heteroaryl is pyridinyl, then said pyridinyl is further substituted with one or more Z1.
78. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R3 is C6-io aryl optionally substituted with Z1.
79. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R3 is C6-io aryl optionally substituted with Z1;
wherein when said C6-io aryl is cyanophenyl then said cyanophenyl is further substituted with one or more oxo, halo, -NO2, -N3, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein said C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zla.
80. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R3 is a 4- 12 membered heterocyclyl optionally substituted with Z1.
81. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R3 is a 4-12 membered heterocyclyl optionally substituted with Z1;
wherein when said 4-12 membered heterocyclyl is hydroxypyrrolidinyl then said hydroxypyrrolidinyl is further substituted with one or more oxo, halo, -CN, -N02, -N3, Ci-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), - N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said Ci_g alkyl, C2_6 alkenyl, C2_6 alkynyl, C3_i5 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla.
82. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R3 is C3-io cycloalkyl optionally substituted with Z1.
83. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R3 is C3_6 cycloalkyl substituted with one or more Z1.
84. The compound of Claims 1-66, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R3 is C7-io cycloalkyl optionally substituted with Z1.
85. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R4 is H, halo, -N02, -CN, -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)C(0 R1Z, -N(R1Z)C(0)0-R , -N(R1Z)S(0)2(R ), -N(R1Z)C(0)-N(R1Z)( R1Z), -S(0)2R ), -SR or -S(0)2N(R12)( R12).
86. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R4 is -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R9)( R9), -NH(R9), -N(R12)C(0
R12, -N(R12)C(0)0-R12, -N(R12)S(0)2(R12), -N(R12)C(0)-N(R12)( R12), -S(0)2(R12 ), -S- R12 or -S(0)2N(R12)( R12);
wherein when said -N(H)( R9) is NH(Ci_3 alkyl), -N(H)( R9) is NH(Ci_4 hydroxy alkyl), or -O-R12 is -0(Ci_3 alkyl), then said NH(Ci_3 alkyl), NH(Ci_4 hydroxy alkyl), or -0(Ci_3 alkyl) is further substituted with one or more oxo, halo, -N02, -CN, -N3, C4_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O- R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)- C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein said C4_9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with Zla.
87. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R4 is selected from -0(C4 alkyl) or -N(H)(C4 alkyl); wherein said -0(C4 alkyl) is optionally substituted with Zla;
wherein said -N(H)(C4 alkyl) is optionally substituted with oxo, halo, -N02, -CN, -N3, Ci-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)(V), -N(R12)2(R12) +, -N(R12)-C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), - N(R12)S(0)2(R12), -N(R12)S(0)2-N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, - OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein said C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zla.
88. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R4 is Ci alkyl optionally substituted with Z1.
89. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R4 is Ci-2 alkyl optionally substituted with F and further substituted with one or more oxo, -CI, -N02, -N3, -CN, C3-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)-R12, -C(0)0-R12, -C(0
N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0-R12, - N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2R12or -S(0)2N(R12)( R12); and
wherein said C3-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3 5 cycloalkyl, Ci-8 haloalkyl, ary] heteroaryl, or heterocyclyl is optionally substituted with Zla.
90. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R4 is C3 alkyl substituted with one or more Z1.
91. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R4 is C4 alkyl optionally substituted with Z1.
92. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R4 is C2 alkynyl optionally substituted with Z1.
93. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R4 is C2 alkenyl optionally substituted with Z1.
94. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R4 is a 10 membered heteroaryl optionally substituted with Z1.
95. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R4 is a 5-10 membered heteroaryl optionally substituted with Z1;
wherein when said 5-10 membered heteroaryl is pyridinyl then said pyridinyl is further substituted with one or more Z1.
96. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R4 is C6-io aryl optionally substituted with Z1.
97. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R4 is C6-io aryl optionally substituted with Z1;
wherein when said C6-io aryl is cyanophenyl then said cyanophenyl is further substituted with one or more oxo, halo, -NO2, -N3, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); and
wherein said C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zla.
98. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R4 is a 4- 12 membered heterocyclyl optionally substituted with Z1.
99. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
R4 is a 4-12 membered heterocyclyl optionally substituted with Z1; wherein when said 4-12 membered heterocyclyl is hydroxypyrrolidinyl then said hydroxypyrrolidinyl is further substituted with one or more oxo, halo, -CN, -N02, -N3, C1-9 alkyl, C2-6 alkenyl,
C2-6 alkynyl, C3_u cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-
R9, -C(0)R12, -C(0)0-R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-
C(0)R12, -N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2-
N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)-
N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12); wherein said C1-9 alkyl, C2_6 alkenyl, C2_6 alkynyl, C3-i5 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl is optionally substituted with Zla.
100. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R4 is C3-io cycloalkyl optionally substituted with Z1.
101. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R4 is C3_6 cycloalkyl substituted with one or more Z1.
102. The compound of Claims 1-84, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R4 is C7-io cycloalkyl optionally substituted with Z1.
103. The compound of Claims 1-102, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein at least one of R5, R6 or R7 is independently selected from H, halo, -N02, -CN, -O-R12, -C(O)- R12, -C(0)-N(R12)( R12), -N(R9)( R9), NH(R9), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, or - N(R12)S(0)2(R12).
104. The compound of Claims 1-102, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein at least one of R5, R6 or R7 is independently selected from -N02, -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R9)( R9), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, or -N(R12)S(0)2(R12).
105. The compound of Claims 1-102, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein at least one of R5, R6 or R7 is independently Ci-5 alkyl optionally substituted with Z1.
106. The compound of Claims 1-102, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein at least one of R5, R6 or R7 is independently Ci-2 alkyl optionally substituted with F and substituted with one or more oxo, -CI, -N02, -N3, -CN, C3_9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-i5 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)-R12, -C(0)0- R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0- R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)-N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, - S(0)(NH)R12, -S(0)2R12or -S(0)2N(R12)( R12); wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zla.
107. The compound of Claims 1-102, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein at least one of R5, R6 or R7 is independently C3 alkyl substituted with one or more Z1.
108. The compound of Claims 1-102, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein at least one of R5, R6 or R7 is independently C4-5 alkyl optionally substituted with Z1.
109. The compound of Claims 1-102, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein at least one of R5, R6 or R7 is independently cyclopropyl, oxetanyl, or azetidinyl optionally substituted with Z1.
110. The compound of Claims 1-102, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein at least one of R5, R6 or R7 is independently cyclopropyl, oxetanyl, or azetidinyl; wherein said cyclopropyl is substituted with one or more Z1 ; wherein said oxetanyl or azetidinyl is optionally substituted with Z1.
111. The compound of Claims 1 - 110, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein no more than two of R3, R4, R5, R6 or R7 are H.
112. The compound of any of Claims 1-111, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R3 is H or F.
113. The compound of any of Claims 1-112, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R4 is H, F, -CN or CI.
114. The compound of any of Claims 1-113, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R5 is H or F.
115. The compound of any of Claims 1-114, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R6 is H or F.
116. The compound of any of Claims 1-115, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R7 is H or F.
117. The compound of Claim 1-116, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein:
Z1 is selected H, halo, -CN, C1-9 alkyl, C3-15 cycloalkyl, aryl, heteroaryl, heterocyclyl, - O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)C(0)-R12, -N(R12)C(0)0- R12, -N(R12)S(0)2(R12), -OC(0)-N(R12)( R12), -S(0)2R12 or -S(0)2N(R12)( R12); and wherein any alkyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zla.
118. A pharmaceutical composition comprising a compound of any of claims 1-117, together with a pharmaceutically acceptable carrier, and optionally a diluent.
119. A method of treating an inflammation related disease or disorder in a patient in need thereof, comprising administering to said patient a compound of any of claims 1- 117, or a pharmaceutical composition of claim 118.
120. A compound of claim 1-117 or a pharmaceutically acceptable salt stereoisomer, mixture of stereoisomers, or deuterated analog thereof.
121. The compound of Claim 1-117, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, wherein R1 is 5-10 membered heteroaryl optionally substituted with Z1, wherein when said 5-10 membered heteroaryl is furanyl, pyranyl, pyrraolyl, imidazolyl, pyrazolyl, triazoyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, thiaphenyl, oxazoyl, thiazoyl, said 5-10 membered heteroaryl is optionally substituted with a 5-12 membered bicyclic ring or a 5-12 membered hetero bicyclic ring, wherein the bicyclic ring and the hetero bicyclic ring may be fused, spiro or bridged.
122. The compound of claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is 5-12 membered bicyclic optionally substituted with Z1.
123. The compound of claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is 5-12 membered bicyclic optionally substituted with C1-3 alkyl, C2-6 alkenyl, C2-6 alkynl, 3-6 membered cyclo alkyl, 3-6 membered heterocyclyl, 5-6 membered aryl, or 5-6 membered heteroaryl, where the Ci_3 alkyl, C2-6 alkenyl, C2-6 alkynl, 3-6 membered cyclo alkyl, 3-6 membered heterocyclyl, 5-6 membered aryl, or 5-6 membered heteroaryl groups can further be substituted with one or more Zla groups.
124. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is 5-12 membered bicyclic heterocyclyl optionally substituted with Z1.
125. The compound of Claim 1, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, R1 is 5-12 membered bicyclic heterocyclyl optionally substituted with C1-3 alkyl, C2-6 alkenyl, C2-6 alkynl, 3-6 membered cyclo alkyl, 3-6 membered heterocyclyl, 5-6 membered aryl, or 5-6 membered heteroaryl, where the C1-3 alkyl, C2-6 alkenyl, C2-6 alkynl, 3-6 membered cyclo alkyl, 3-6 membered heterocyclyl, 5-6 membered aryl, or 5-6 membered heteroaryl groups can further be substituted with one or more Zla groups.
A compound of
Figure imgf000522_0001
(I)
wherein:
R1 and R2 are each independently selected from:
h) Ci-10 alkyl optionally substituted with Z1 ;
i) C3-10 cycloalkyl optionally substituted with Z1 ;
j) 5-10 membered heteroaryl optionally substituted with Z1 ;
k) C6-io aryl optionally substituted with Z1 ;
1) 4-7 membered monocyclic heterocyclyl optionally substituted with Z1 ;
m) 6-12 membered bicyclic heterocyclyl optionally substituted with Z1 ; or n) -N(R12)( R12), -S(0)2R12, -S(0)2N(R12)( R12), or -H; wherein when R1 or R2 is Ci_io alkyl, C3-10 cycloalkyl, 5-10 membered heteroaryl, C6-io aryl, 4-7 membered monocyclic heterocyclyl, 6-12 membered bicyclic heterocyclyl, two Z1 groups either attached to the same atom on R1 or R2, or two Z1 groups attached to adjacent atoms on R1 or R2, append together to form a 3-6 membered cycloalkyl or 3-6 membered heterocyclyl;
R3 and R4 are each independently selected from: i) H, halo, -NO2, -CN, -O-R , -C(0)-R , -C(0)-N(R1Z)( R1Z), -N(R1Z)(
R12), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, -N(R12)S(0)2(R12), -N(R12)C(0)- N(R12)( R12), -S(0)2R12 or -S(0)2N(R12)( R12);
j) Ci-9 alkyl optionally substituted with Z1;
k) C2-9 alkynyl optionally substituted with Z1;
1) C2-9 alkenyl optionally substituted with Z1;
m) 5-10 membered heteroaryl optionally substituted with Z1;
n) C6-io aryl optionally substituted with Z1;
o) 4-12 membered heterocyclyl optionally substituted with Z1; or
p) C3-10 cycloalkyl optionally substituted with Z1;
, R6 and R7 are each independently selected from:
d) H, halo, -N02, -CN, -O-R12, -C(0)-R12, -C(0)-N(R12)( R12), -N(R12)(
R12), -N(R12)C(0)-R12, -N(R12)C(0)0-R12, or -N(R12)S(0)2(R12; e) Ci-5 alkyl optionally substituted with Z1; or
f) Cyclopropyl, oxetanyl or azetidinyl optionally substituted with Z1;
Z1 is independently oxo, halo, -NO2, -N3, -CN, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)-R12, -C(0)0- R12, -C(0)-N(R12)( R12), -N(R12)( R12), -N(R12)2(R12)+, -N(R12)C(0)-R12, -N(R12)C(0)0- R12, -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -NR12S(0)2N(R12)( R12), - NR12S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(0)-N(R12)( R12), -Si(R12)3, -S- R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12 or -S(0)2N(R12)( R12);
wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Zla;
each Zla is independently oxo, halo, -NO2, -CN, -N3, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, Ci_8 haloalkyl, aryl, heteroaryl, heterocyclyl, -O-R12, -C(0)R12, -C(0)0- R12, -C(0)N(R12)( R12), -N(R12)( R12), -N(R12)2(R12) +, -N(R12)-C(0)R12, - N(R12)C(0)0(R12), -N(R12)C(0)N(R12)( R12), -N(R12)S(0)2(R12), -N(R12)S(0)2- N(R12)( R12), -N(R12)S(0)20(R12), -OC(0)R12, -OC(0)OR12, -OC(O)- N(R12)( R12), -Si(R12)3, -S-R12, -S(0)R12, -S(0)(NH)R12, -S(0)2R12
or -S(0)2N(R12)( R12); wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or
heterocyclyl is optionally substituted with Zlb; each R12 is independently H, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl or heterocyclyl, wherein the C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl or heterocyclyl can further optionally be substituted with one or more Zla group; each Zlb is independently oxo, hydroxy, halo, -NO2, -N3, -CN, C1-9 alkyl, C2-6 alkenyl, C2- 6 alkynyl, C3-15 cycloalkyl, Ci-8 haloalkyl, aryl, heteroaryl, heterocyclyl, -0(Ci_9 alkyl), -0(C2-6 alkenyl), -0(C2-6 alkynyl), -0(C3-i5 cycloalkyl), -0(Ci_8 haloalkyl), - O(aryl), -O(heteroaryl), -O(heterocyclyl), -NH2, -NH(Ci_9 alkyl), -NH(C2-6
alkenyl), -NH(C2-6 alkynyl), -NH(C3-15 cycloalkyl), -NH(Ci_8 haloalkyl), -NH(aryl), - NH(heteroaryl), -NH(heterocyclyl), -N(C1-9 alkyl)2, -N(C3-15 cycloalkyl)2, -N(C2-6 alkenyl)2, -N(C2-6 alkynyl)2, -N(C3-15 cycloalkyl)2, -N(C1-8 haloalkyl)2, -N(aryl)2, - N(heteroaryl)2, -N(heterocyclyl)2, -N(Ci-9 alkyl)(C3_i5 cycloalkyl), -N(Ci-9 alkyl)(C2-6 alkenyl), -N(C1-9 alkyl)(C2-6 alkynyl), -N(C1-9 alkyl)(C3-15 cycloalkyl), -N(C1-9 alkyl)(C1-8 haloalkyl), -N(C1-9 alkyl)(aryl), -N(C1-9 alkyl)(heteroaryl), -N(C1-9
alkyl)(heterocyclyl), -C(0)(C1-9 alkyl), -C(0)(C2-6 alkenyl), -C(0)(C2-6
alkynyl), -C(0)(C3-15 cycloalkyl), -C(0)(C1-8 haloalkyl), -C(0)(aryl), -C(0)(heteroaryl), -C(0)(heterocyclyl), -C(0)0(C1-9 alkyl), -C(0)0(C2-6 alkenyl), -C(0)0(C2-6
alkynyl), -C(0)0(C3-15 cycloalkyl), -C(0)0(C1-8 haloalkyl), -C(0)0(aryl), - C(0)0(heteroaryl), -C(0)0(heterocyclyl), -C(0)NH2, -C(0)NH(Ci_9
alkyl), -C(0)NH(C2-6 alkenyl), -C(0)NH(C2-6 alkynyl), -C(0)NH(C3-15
cycloalkyl), -C(0)NH(Ci_8 haloalkyl), -C(0)NH(aryl), -C(0)NH(heteroaryl), - C(0)NH(heterocyclyl), -C(0)N(C1-9 alkyl)2, -C(0)N(C3-15 cycloalkyl)2, -C(0)N(C2-6 alkenyl)2, -C(0)N(C2-6 alkynyl)2, -C(0)N(C3-i5 cycloalkyl)2, -C(0)N(d_8 haloalkyl)2, - C(0)N(aryl)2, -C(0)N(heteroaryl)2, -C(0)N(heterocyclyl)2, -NHC(0)(Ci_9
alkyl), -NHC(0)(C2-6 alkenyl), -NHC(0)(C2-6 alkynyl), -NHC(0)(C3-15
cycloalkyl), -NHC(0)(Ci_8 haloalkyl), -NHC(0)(aryl), -NHC(0)(heteroaryl), - NHC(OXheterocyclyl), -NHC(0)0(Ci_9 alkyl), -NHC(0)0(C2-6 alkenyl), -NHC(0)0(C2- 6 alkynyl), -NHC(0)0(C3-i5 cycloalkyl), -NHC(0)0(Ci_8 haloalkyl), -NHC(0)0(aryl), - NHC(0)0(heteroaryl), -NHC(0)0(heterocyclyl), -NHC(0)NH(Ci_9
alkyl), -NHC(0)NH(C2-6 alkenyl), -NHC(0)NH(C2-6 alkynyl), -NHC(0)NH(C3-i5 cycloalkyl), -NHC(0)NH(Ci_8 haloalkyl), -NHC(0)NH(aryl), - NHC(0)NH(heteroaryl), -NHC(0)NH(heterocyclyl), -SH, -S(C1-9 alkyl), -S(C2-6 alkenyl), -S(C2-6 alkynyl), -S(C3-15 cycloalkyl), -S(C1-8 haloalkyl), -S(aryl), - S(heteroaryl), -S(heterocyclyl), -NHS(0)(Ci_9 alkyl), -N(C1-9 alkyl)(S(0)(C1-9 alkyl), - S(0)N(d_9 alkyl)2, -S(0)(d_9 alkyl), -S(0)(NH)(d_9 alkyl), -S(0)(C2_6
alkenyl), -S(0)(C2_6 alkynyl), -S(0)(C3-15 cycloalkyl), -S(0)(C1-8 haloalkyl), -S(0)(aryl), -S(0)(heteroaryl), -S(0)(heterocyclyl), -S(0)2(C1-9 alkyl), -S(0)2(C2_6
alkenyl), -S(0)2(C2_6 alkynyl), -S(0)2(C3- 15 cycloalkyl), -S(0)2(Ci-8 haloalkyl), - S(0)2(aryl), -S(0)2(heteroaryl), -S(0)2(heterocyclyl), -S(0)2NH(Ci_9 alkyl),
or -S(0)2N(d_9 alkyl)2;
wherein any alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with one or more halo, Ci-9 alkyl, Ci-8 haloalkyl, -OH, -NH2, -NH(Ci-9 alkyl), -NH(C3-i5 cycloalkyl), -NH(Ci_8 haloalkyl), -NH(aryl), -NH(heteroaryl), -NH(heterocyclyl), -N(C1-9 alkyl)2, -N(C3-15 cycloalkyl)2, -NHC(0)(C3-i5 cycloalkyl), -NHC(0)(Ci_8 haloalkyl), - NHC(0)(aryl), -NHC(0)(heteroaryl), -NHC(0)(heterocyclyl), -NHC(0)0(Ci_9 alkyl), -NHC(0)0(C2_6 alkynyl), -NHC(0)0(C3-i5 cycloalkyl), -NHC(0)0(Ci_8 haloalkyl), -NHC(0)0(aryl), -NHC(0)0(heteroaryl), -NHC(0)0(heterocyclyl), - NHC(0)NH(d_9 alkyl), -S(0)(NH)(d_9 alkyl), S(0)2(d_9 alkyl), -S(0)2(C3-i5 cycloalkyl), -S(0)2(C1-8 haloalkyl), -S(0)2(aryl), -S(0)2(heteroaryl), - S(0)2(heterocyclyl), -S(0)2NH(d_9 alkyl), -S(0)2N(d_9 alkyl)2, -0(C3-i5
cycloalkyl), -0(Ci_8 haloalkyl), -O(aryl), -0(he ternary 1), -O(heterocyclyl), or -0(Ci_9 alkyl); and
with the proviso that when R1 is C3 alkyl, R2 is C5 alkyl substituted with F and hydroxyl, R3, R5, R6, R7 are H, and R4 is CN, then R1 is substituted with Z1;
or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof.
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