WO2018137251A1 - Detector and detection method for pulse wave propagation velocity - Google Patents

Detector and detection method for pulse wave propagation velocity Download PDF

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Publication number
WO2018137251A1
WO2018137251A1 PCT/CN2017/072777 CN2017072777W WO2018137251A1 WO 2018137251 A1 WO2018137251 A1 WO 2018137251A1 CN 2017072777 W CN2017072777 W CN 2017072777W WO 2018137251 A1 WO2018137251 A1 WO 2018137251A1
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signal
frequency
physiological
detection
test
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PCT/CN2017/072777
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French (fr)
Chinese (zh)
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王尧
陈驰
朱宇东
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悦享趋势科技(北京)有限责任公司
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Priority to PCT/CN2017/072777 priority Critical patent/WO2018137251A1/en
Publication of WO2018137251A1 publication Critical patent/WO2018137251A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026Measuring blood flow
    • A61B5/0285Measuring or recording phase velocity of blood waves

Abstract

A detector and detection method for a pulse wave propagation velocity. The detector comprises: a first signal generation circuit (10) used to send out a detection signal having a predetermined frequency; a first signal detection circuit (20) used to detect a first physiological signal carried in a detection signal having the predetermined frequency after the detection signal passes through a tissue under test at a first position; a second signal detection circuit (30) used to detect a second physiological signal carried in a detection signal after the detection signal passes through the tissue under test at a second position, wherein the first signal generation circuit (10) and the first signal detection circuit (20) form a first transceiving circuit, and the first signal generation circuit (10) and the second signal detection circuit (30) form a second transceiving circuit; and a processor (40) used to determine, according to the first physiological signal and the second physiological signal, a pulse wave propagation velocity in the tissue under test. The detector solves the technical problem of inaccuracy in the prior art in which a pulse wave propagation velocity is detected by means of the Doppler effect.

Description

Detector and method of detecting a pulse wave propagation velocity FIELD

The present invention relates to the field of detection, particularly, to a pulse wave propagation velocity detector and detection methods.

Background technique

Detection of the pulse wave propagation velocity of the organism to organism health diagnosis is important, for example, blood flow velocity and blood flow within the blood vessel has a certain value in the diagnosis of cardiovascular disease, especially for on cycle oxygen, the blocking capability, with or without turbulence, atherosclerosis and the like can provide valuable diagnostic.

In the prior art, in order to examine the heart, blood vessel motion, understanding of the blood flow rate, it may be achieved by transmitting ultrasound. Because blood flow within the vessel is the object, the ultrasonic vibration source so that the blood between the relative movement of the Doppler effect is generated. When moving toward the ultrasonic source of blood, the wavelength of the reflected wave is compressed, thereby increasing the frequency. Students leave the blood over movement, the longer wavelength of the reflected wave, the frequency becomes smaller. Reflected wave frequency increases or decreases the amount of blood flow velocity is proportional to the amount of frequency shift according to an ultrasonic wave, measurement of blood flow velocity.

However, such a detection method using the Doppler effect detected signal is very weak, susceptible to interference, so the test results are not accurate, and the ultrasonic measuring pulse wave (Pulse Wave Velocity, simply referred to as PWV) complex equipment, expensive, require professional operation, not portable if you use other pressure sensors to measure, due to the need to measure from a distance and need help, so inconvenient to operate.

In response to these problems has yet to come up with effective solutions.

SUMMARY

Embodiment of the present invention provides a detector and method for detecting a pulse wave propagation velocity, the propagation velocity results to at least solve the prior art pulse wave detected by the Doppler effect the technical problem of inaccuracy.

According to one aspect of embodiments of the present invention, there is provided a probe of one kind of pulse wave propagation velocity, comprising: a first signal generating circuit for detecting a predetermined frequency of the emitted signal; a first signal detection circuit for detecting said predetermined first physiological signal detection signal frequency after a first test biological tissue carrying position; a second detection signal the signal detection circuit for detecting a predetermined frequency after the second test biological tissue carrying a first position two physiological signals, wherein the first signal generating circuit and a signal detection circuit of the first circuit first transceiver, the first signal generation circuit and the second signal detection circuit of the second transmitting and receiving circuit; processor for physiological signal propagating speed of the first and second physiological signal to determine the pulse wave measured in the physiological tissue.

In an embodiment of the present invention, the first signal generating circuit comprising: a frequency f1 generator for emitting a detection signal frequency f1; a frequency f2 generator for emitting a detection signal frequency f2; a first combiner , a generator connected to the frequency f1 and the frequency f2 generator, for detecting the frequency signal to detect the signal frequency f1 and f2, performing combination to obtain a first combined signal; first a transmitting antenna, connected to the first combiner, for transmitting said first combined signal, wherein said probe signal includes a predetermined frequency of said first signal combiner.

In an embodiment of the present invention, the first signal detection circuit comprises: a first receiving antenna for receiving a first signal under test wherein the first test signal carries the first physiological signal, the said first physiological signal is a physiological signal of said first signal combiner through the biological tissue under test said generated first position; a first splitter, connected to the first receiving antenna, according to the frequency said first test signal into two paths, a first measured signal to give a frequency f1 and a frequency f2 is a first test signal; a first frequency f1 detector, connected to the first splitter, for detecting the frequency of a first test signal is a physiological signal f1 is carried; a first frequency f2 detector, connected to the first splitter, for detecting the frequency f2 of the first signal under test carrying the physiological signal, said second signal detection circuit comprises: a second receiving antenna for receiving a second test signal, wherein the second test signal carries a second physiological signal, said first two said physiological signal is a first signal through the combiner A second physiological signal measured position of the biological tissue is generated; a second splitter, connected to said second receiving antenna, according to said second test signal frequency is divided into two, for the first frequency f1 is obtained and two measured signals of the second frequency f2 test signal; a frequency f1 a second detector connected to the second splitter, for detecting the second test signal frequency f1 of physiological carried signal; a second frequency f2 detector connected to the second splitter for detecting a physiological signal frequency f2 of the second test signal carried.

In an embodiment of the present invention, the processor is configured according to the equation PWV = d / deltaT calculating pulse wave velocity measured in biological tissue in which, deltaT = (deltaT1 + deltaT2) / 2, deltaT1 said first f1 frequency detector detects the frequency of the test signal frequency f1 a first physiological signal carried in the second frequency f1 and the detector detects the test signal to the second physiological signal f1 is carried in a delay difference, deltaT2 to the frequency of the first frequency f2 is detected by the detector of physiological signals of the frequency f2 of the first test signal and the second carried frequency f2 is detected by the detector f2 a second delay difference between the measured physiological signal carried signal, deltaT delay difference of an average value, d is the distance between the first position and the second position, PWV is the pulse wave the propagation velocity measured in biological tissue.

According to another aspect of embodiments of the present invention, one kind of probe it is also provided a pulse wave propagation velocity, comprising: a first signal generation circuit for detecting a first predetermined frequency of the emitted signal; a first signal detection circuit for first physiological signal detecting a first detection signal after the predetermined frequency of the first test biological tissue carrying position; a second signal generating circuit for detecting a second predetermined frequency of the emitted signal; a second signal detection circuit, a second physiological signal of the second detection signal for detecting a predetermined frequency after the test biological tissue carrying a second position, wherein the first signal generation circuit and said first detection signal a first transceiver circuit circuit, a second signal generating circuit and the second signal detection circuit of the second transceiver circuitry; a processor for determining from the first physiological signal and the second pulse wave signal in the physiological test the propagation velocity of the biological tissue.

In an embodiment of the present invention, the first signal generating circuit comprises: a frequency f11 generator for emitting a detection signal f11 of the frequency; frequency f21 generator for emitting a detection signal frequency f21; a first combiner , a generator with the frequencies f11 and f21 of the frequency generator is connected, for the frequency detection signal and said detection signal frequencies f11 and f21 is performing combination to obtain a first combined signal, wherein the first probe signal comprises the predetermined frequency of the first combiner signal; a first transmitting antenna, connected to the first combiner, for transmitting said first combined signal, said first signal detection circuit comprises: a first receiving antenna for receiving a first signal under test wherein the first test signal carries the first physiological signal, the first physiological signal for said first combiner physiological test signal through the first biological tissue generated position; a first splitter, connected to the first receiving antenna, according to the frequency of the first test signal into two, to give the frequency f11 of the first test A first number and a frequency f21 of the signal to be measured; f11 frequency detector, connected to the first splitter, for detecting the frequency of a first signal under test is a physiological signal f11 is carried; detection frequency f21 is connected to the first splitter, for detecting the physiological signal frequency f21 of the first test signal carried.

In an embodiment of the present invention, the second signal generating circuit comprises: a frequency f12 generator for emitting a detection signal f12 of the frequency; f22 frequency generator for emitting a detection signal frequency f22; a second combiner is connected to the frequency generator and the frequency f12 f22 generator for the frequency detection signal and said detection signal is a frequency f12 f22 performing combination to obtain a second combined signal, wherein , the second probe signal comprises said second predetermined frequency signal combiner; second transmit antenna, and the second combiner is connected, for transmitting said second signal combiner, the second signal detection circuitry comprises: a second receiving antenna for receiving a second test signal, wherein the second test signal carries a second physiological signal, and the second physiological signal for said second combiner physiological test signal through the second position of the biological tissue is generated; a second splitter, connected to the second receiving antenna, according to the frequency of the second test signal into two, to give the frequency f12 of the first test Number and frequency of a first test signal f22; f12 frequency detector, connected to the second splitter, for detecting the frequency of the second physiological signal of the test signal carried f12; f22 frequency detector is connected to the second splitter, for detecting the frequency of the second physiological signal of the test signal carried f22.

In an embodiment of the present invention, the processor is configured according to the equation PWV = d / deltaT calculating pulse wave velocity measured in biological tissue in which, deltaT = (deltaT1 + deltaT2) / 2, deltaT1 to the frequency f11 a frequency detector detects a first test signal is a physiological signal f11 of the frequency of the carried frequency f12 and the detector detects the delay difference is the second physiological signal of the test signal carried f12, a first physiological signal measured deltaT2 carries a signal f21 of the frequency of the frequency f21 is detected by detector and the frequency detector detects the frequency f22 to f22 is a second test signal carries the physiological signal delay difference, deltaT average value of delay difference, d is a distance between the first position and the second position, PWV is the pulse wave measured in the physiological tissue transmission speed.

According to another aspect of an embodiment of the present invention, there is provided a method of detecting a pulse wave propagation velocity, comprising: detecting a signal emitted by a first predetermined frequency signal generating circuit; said first predetermined signal by the detection circuit detects the frequency first physiological signal detection signal after a first test biological tissue carrying position; a second detection signal by the physiological signal detection circuit detects a second signal of the predetermined frequency after the second test biological tissue carrying position, wherein said first signal generating circuit and said first signal detection circuit constituting a first transceiver circuit, a signal detecting circuit and the second circuit of the first signal generating circuit constituting the second transceiver; according to the first physiological signal and the second physiological signal to determine the pulse wave velocity measured in a physiological tissue.

According to another aspect of an embodiment of the present invention, there is provided a method of detecting a pulse wave propagation velocity, comprising: issuing a first detection signal by a first predetermined frequency signal generating circuit; said first predetermined signal is detected by the detection circuit a first signal detecting first physiological signal frequency after a first test biological tissue carrying position; a second detection signal issued at a predetermined frequency by a second signal generating circuit; said predetermined frequency by a second signal detection circuit for detecting a second detection signal a second physiological signal measured after the biological tissue carrying a second position, wherein said first signal generating circuit and said first signal detection circuit constituting a first transceiver circuit, a second signal generator signal detection circuit and the second circuit the second transceiver circuit; determining a pulse wave propagation velocity measured in the biological tissue in the physiological signal based on the first and the second physiological signal.

In an embodiment of the present invention, a predetermined detection frequency of the first signal emitted signal generating circuit; a first physiological signal detection signal of the first predetermined frequency signal detection circuit detecting a first biological tissue measured after carrying position; a second detecting a second physiological signal of a predetermined frequency signal detected by the detector circuit after the test biological tissue carrying a second position, wherein the first circuit and a signal detecting circuit composed of a first transceiver a first signal generating circuit, a first signal generating circuit second signal detection circuit and the second transceiver circuit; processor determines a pulse wave velocity measured in biological tissue in the physiological signal according to the first and second physiological signal. Two physiological signals measured positions of the biological tissue detected by transceiver circuitry carried by the two pulse wave velocity is determined in a physiological tissue, to more accurately determine the time difference between the physiological signal, a radio wave measurement realized by two pulse wave propagation velocity in a physiological tissue technical effect more accurate, thereby solving the prior art Doppler effect detected by a pulse wave propagation velocity inaccurate results technical problems.

BRIEF DESCRIPTION

The drawings described herein to provide a further understanding of the present invention, constituting part of the invention, exemplary embodiments of the present invention and the description, serve to explain unduly limit the present invention, it does not constitute the present invention. In the drawings:

1 is a schematic pulse wave velocity detector according to a first embodiment of the present invention;

FIG 2 is a schematic diagram of the detector to the pulse wave propagation velocity to a second embodiment of the present invention;

3 is a schematic pulse wave velocity detector according to a third embodiment of the present invention;

FIG 4 is a schematic diagram of the detector to the pulse wave propagation velocity to a fourth embodiment of the present invention;

5 is a flowchart a process for detecting a pulse wave propagation velocity of the first embodiment of the present invention; and

FIG 6 is a flowchart illustrating a method of detecting a pulse wave propagation velocities of the second embodiment of the present invention.

detailed description

In order to make those skilled in the art better understand the present invention, the following embodiment of the present invention in conjunction with the accompanying drawings of embodiments, the technical solutions in the embodiments of the present invention will be clearly and completely described, obviously, the described embodiments are merely It is a part of the embodiment of the present invention rather than all embodiments. Based on the embodiments of the present invention, all other embodiments of ordinary skill in the art without creative efforts shall be made available, should fall within the scope of the present invention.

Incidentally, the above-mentioned book and in the figures the terms "first," "second," and the like are used for distinguishing between similar objects, and not necessarily for describing a particular sequential or disclosure of the present specification and claims the order requirements. It should be understood that the data so used are interchangeable under appropriate circumstances, embodiments of the present invention described herein are capable to addition order than those in the embodiments illustrated or described herein. Furthermore, the terms "including" and "having," as well as any of their deformation, intended to cover non-exclusive inclusion, for example, comprising a series of steps or the process unit, the method, system, or apparatus is not necessarily limited expressly listed units or those steps, but may include other steps not or inherent to these units or process, method, article, or apparatus clearly listed

First, the technical terms of the present application relates to the embodiment explained as follows:

Pulse wave: a heart beat pulse wave (vibration) and the blood vessel along the outer peripheral arterial propagation formed, its propagation speed depends on the physical and geometrical properties of the propagation medium, e.g., flexible, the size of the artery lumen, density and viscosity of blood and the like, particularly closely related to the elasticity, the caliber and thickness of the arterial wall.

According to an embodiment of the present invention, there is provided a probe of one kind of pulse wave propagation velocity. 1 is a schematic of the detector pulse wave velocity of the first embodiment according to the present invention, shown in Figure 1, the probe comprising the following components:

First signal generating circuit 10 for detecting a predetermined frequency signal emitted.

A first signal detection circuit 20 for detecting a predetermined frequency of the first physiological signal detection signal after a first test biological tissue carrying position.

Second signal detection circuit 30, a second detection signal for detecting a physiological signal of a predetermined frequency after the test biological tissue carrying a second position, wherein the first circuit and a signal detecting circuit composed of a first transceiver a first signal generating circuit The first signal generating circuit and a second signal detection circuit of the second transceiver circuitry.

The processor 40, to determine the pulse wave velocity measured in biological tissue in the physiological signal according to the first and second physiological signal.

The processor 40 can be used as a separate module, it may also be incorporated in the first signal or the second signal detecting circuit detecting circuit, the processor may be one or may be two, if a processor, the processor may receive a first first physiological data first physiological signal and the second signal detection circuit detecting circuit and a second physiological signal obtained is then processed, if the processor is two, a process wherein the first signal detection circuit detects the signal, another second signal processing circuit detecting a second physiological signal is detected, the processor connected to the detector embodiment may be a flexible, it is not limited to some specific connection.

In an embodiment of the present invention, the first signal generation circuit comprises: a frequency f1 generator for emitting a detection signal frequency f1; a frequency f2 generator for emitting a detection signal frequency f2; a first combiner, generator is connected to the frequency f1 and frequency f2 generator, for detecting signal frequencies f1 and frequency f2 combiner detection signals to obtain a first combined signal; a first transmitting antenna, and a first combiner connection, for transmitting a first combined signal, wherein the predetermined frequency of the probe signal comprises a first combined signal.

In an embodiment of the present invention, the first signal detection circuit comprises: a first receiving antenna for receiving a first signal under test wherein the first test signal carries the first physiological signal, the first signal is a first physiological physiological test signal through the signal combiner biological tissue generated by a first position; a first splitter, connected to the first receiving antenna, according to the frequency of the first test signal into two, to give a first frequency f1 a test signal of a first frequency f2 and the signal under test; the first frequency f1 detector, connected to the first splitter, for detecting a physiological signal of a first frequency f1 test signal carried in; first f2 frequency detector, connected to the first splitter, for detecting a physiological signal frequency f2 of the first test signal carried.

Second signal detection circuit comprises: a second receiving antenna for receiving a second test signal, wherein the second test signal carries a second physiological signal, a second physiological signal is a first position through the second combined signal biological tissue measured physiological signal generated; a second splitter, connected to the second receiving antenna, according to the frequency of the second test signal into two, to give a second frequency f1 and a frequency signal to be measured f2 is a second test signal; a frequency f1 a second detector connected to the second splitter, for detecting a physiological signal frequency f1 and a second test signal carried in; the second frequency f2 detector, and the second two splitters connection for detecting a frequency of a second signal to be detected physiological signal f2 is carried.

In an embodiment of the present invention, a processor for calculating a pulse wave velocity measured in biological tissue to be tested in accordance with equation PWV = d / deltaT, wherein, deltaT = (deltaT1 + deltaT2) / 2, deltaT1 a first frequency f1 physiological signal delay difference detector detects a frequency f1 of a first test signal carried in the physiological signal and the second detector detects the frequency f1 to the second frequency f1 of the signal to be measured is carried, deltaT2 is a first detector detecting the frequency f2 to frequency f2 test signal carried in a first frequency and a second frequency f2 physiological signal detector for detecting the second test signal f2 physiological signal carried in delay difference, deltaT delay difference of an average value, d is the distance between the first and second positions, PWV is the pulse wave velocity measured in a physiological tissue. For example, the first and second positions are mounted in position on the user's arm, between the first and second positions the distance, measured biological tissue may be blood, tissue fluid may be other, so as to test physiological blood tissue, for example, during a systole, a portion of blood flow from the first position to the second position, the first detection signal is issued to the time delay between the received test signal will be the two detectors detects delay skew can be obtained as the difference between the two average delay difference can be the difference between the average delay, the pulse wave can be calculated according to the distance between the delay difference of the average value and two positions in the blood transmission speed.

In an embodiment of the present invention, in addition to the dual-income single embodiment, may also be a single receiving four or more single admission other receiving circuit, easy considering the actual application and the computational complexity issues wearer, Example shows the single receiver could detect the structure of the present invention.

Embodiments of the present invention further provides a preferred embodiment, the preferred embodiment is a preferred embodiment of the above-described first embodiment, FIG 2 is a schematic diagram of the detector pulse wave velocity according to a second embodiment of the present invention, such as As shown in FIG. 2, the probe comprising the following components:

Generator 710 generates the frequency f1 to detect the signal frequency f1 and frequency f2 generator 720 generates the frequency detection signals f2, f1 and f2 detection signal and the detection signal after a first combiner combiner 620 by a transmit antenna 520 launch out.

f1 and f2 signal after the signal receiving antenna 510 receives a motion disturbance biological tissue, after a first branch splitter 610, the frequency f1 detector 810 detects a physiological signal carried W11 f1, f2 frequency detector 820 detects f2 w21 physiological signals carried.

f1 and f2 signal after the signal receiving antenna 530 moving two biological tissue disturbances after the second branch splitter 630, the frequency f1 detector 830 detects a physiological signal carried W12 f1, f2 frequency detector 840 detects f2 carry physiological signals w22.

W11 and w12 signal comparison signal, a skew can be obtained deltaT1 two signals.

W21 and w22 signal comparison signal, can be a delay of two signals deltaT2 difference.

Thus two-way average delay is deltaT = (deltaT1 + deltaT2) / 2.

Since the distance d is known, so PWV = d / deltaT. Wherein, PWV may represent the propagation speed of the pulse wave.

By way of averaging a plurality of measurements, measuring n sets of the frequencies, then deltaTn averaged to eliminate some interference and unexpected accidental errors, the measurement can be more accurate in PWV.

3 is a schematic of the pulse wave propagation velocity detector of a third embodiment of the present invention, shown in Figure 3, the probe comprising the following components:

A first first physiological signal detection circuit 21, a first detection signal for detecting a predetermined frequency after the first test biological tissue carrying position; a first signal generating circuit 11, for detecting a first predetermined frequency signal emitted the first signal of the second detection circuit 22, the second detection signal for detecting a predetermined frequency after the second test biological tissue carrying position; a signal; a second signal generating circuit 12 for detecting a second predetermined frequency signal emitted two physiological signals, wherein the first signal generating circuit and a signal detecting circuit composed of a first first transceiver circuit, a second circuit and a signal detecting circuit composed of the second transceiver a second signal generating circuit; a processor 40, according to a first physiological physiological signal and the second signal to determine a pulse wave velocity measured in a physiological tissue.

A frequency detection circuit to send a signal frequency detection signal and the second signal emitted by the first signal generating circuit occurs may be the same or different.

The processor 40 may be a separate module, may be integrated with the first frequency or the second frequency detector in a detector module, if the processor is a separate module processor and frequency detector may be connected via a wireless network or Bluetooth data communication mode.

In an embodiment of the present invention, the first signal generating circuit 11 comprises: a frequency f11 generator for emitting a detection signal of frequency f11; f21 frequency generator for issuing a signal f21 of the frequency of the probe; a first combiner , connected to the frequency generator and the frequency f21 f11 generator for detecting the frequency of the signal of detection signals f11 and f21 is a frequency combiner to obtain a first combined signal, wherein the first probe signal includes a predetermined frequency, a first combined signal; a first transmitting antenna, connected to the first combiner for transmitting a first signal combiner.

In an embodiment of the present invention, the first signal detection circuit 21 comprises: a first receiving antenna for receiving a first signal under test wherein the first test signal carries the first physiological signal, a physiological signal is at a first a combined signal through the biological tissue measured physiological signal generated by a first position; a first splitter, connected to the first receiving antenna, according to the frequency of the first test signal into two, to give the frequency f11 a first test signal and a frequency of a first test signal f21; f11 frequency detector, connected to the first splitter, for detecting a physiological signal of the first frequency of the test signal carried f11; f21 frequency detector device, connected to the first splitter, for detecting a physiological signal frequency f21 of the first test signal carried.

In an embodiment of the present invention, the second signal generating circuit 12 comprises: a frequency f12 generator for emitting a detection signal of a frequency f12; f22 frequency generator for emitting a detection signal of a frequency f22; a second combiner , connected to the frequency generator and the frequency f12 f22 generator for a frequency of a detection signal f12 and frequency f22 combiner detection signals to obtain a second combined signal, wherein the second probe signal comprises a predetermined frequency, a second combined signal; a second transmit antenna, and the second combiner is connected, for transmitting a second combined signal.

Second signal detection circuit 22 comprises: a second receiving antenna for receiving a second test signal, wherein the second test signal carries a second physiological signal, the second combiner signal is the second physiological signal through a second physiological test tissue location physiological signals generated; a second splitter, connected to the second receiving antenna, according to the frequency of the second test signal into two, to give a first frequency f12 and the frequency of the signal under test the first test signal f22; f12 frequency detector, connected to the second splitter, the physiological signal for detecting a frequency of the second test signal is carried f12; f22 frequency detector, and a second branch connection, for detecting a physiological signal of a frequency f22 of the second test signal carried.

In an embodiment of the present invention, the processor 40 according to equation PWV = d / deltaT calculating pulse wave velocity measured in biological tissue in which, deltaT = (deltaT1 + deltaT2) / 2, deltaT1 detector frequency f11 detected frequency f11 of the signal to be measured is first carried in the physiological signal and the frequency f12 of the frequency detector detects the delay difference is the second physiological signal of the test signal carried f12, deltaT2 detector for the frequency f21 detected frequency f21 of the signal to be measured is first carried in the physiological signal and the frequency f22 of the frequency detector detects the delay difference is the second physiological signal of the test signal carried f22, deltaT for the difference in delay mean value, d is the distance between the first and second positions, PWV is a propagation velocity of the pulse wave.

Embodiments of the present invention further provides a preferred embodiment, the preferred embodiment is a preferred embodiment of the above third embodiment, the detector 4 is a schematic view of a pulse wave velocity to a fourth embodiment of the present invention, such as As shown in FIG. 4, the probe comprising the following components:

Generator 310 generates the sounding frequency f11 frequencies f11, f21 the frequency generator 320 generates the sounding frequency f21, f11 and f21 after the combiner 220 first combiner, transmitted from a transmitting antenna 120. signals f11 and f21 after the signal perturbation motion of the biological tissue receiving a receiving antenna 110, splitter 210 after the first splitter, the frequency f11 detector 410 detects a physiological signal carried W11 f11, f21 the frequency detector 420 detects f21 w21 physiological signals carried.

Frequency generator 330 generates the sounding frequency f12 f12, f22 the frequency generator 340 generates the sounding frequency f22, f12 and f22 after the second combiner combiner 230 and transmitted from two transmitting antenna 130. signals f12 and f22 after the signal receiving antenna 140 two biological tissue motion disturbances, the second demultiplexer 240 after the shunt, frequency f12 detector 430 detects a physiological signal carried W12 f12, f22 the frequency detector 440 detects f22 carry physiological signals w22.

W11 and w12 signal comparison signal, a skew can be obtained deltaT1 two signals.

W21 and w22 signal comparison signal, a skew can be obtained deltaT2 two signals.

Thus two-way average delay is deltaT = (deltaT1 + deltaT2) / 2.

Since the distance d is known, so PWV = d / deltaT. Wherein, PWV may represent the propagation speed of the pulse wave.

In an embodiment of the present invention, in addition double double received embodiment, but also may receive four rounds four, or six rounds and more admission reception circuit, considering the actual application and easy to wear computational complexity issues, Example given double dual probe structure of the present invention is received.

By way of averaging a plurality of measurements, measuring n sets of the frequencies, then deltaTn averaged to eliminate some interference and unexpected accidental errors, the measurement can be more accurate in PWV.

Technical solutions of the embodiments of the present invention may utilize a radio wave sensor to measure the pulse wave, a non-invasive manner, easy to operate, can be measured on the wrist band, without the assistance of others. Because of the characteristics of the circuit solution, pulse characteristics, the measurement time to find the exact time difference technical problems, the present invention utilizes multiple sets of frequency measurements PWV, each constituted by a frequency or pair of frequencies. Each group of frequencies can be a time difference deltaTn, n is the n-th group of frequencies. Since the measurement, a constant PWV, two receiving antenna distance d is constant, the PWV = d / deltaT, deltaT and n is an average value deltaTn group. To obtain more accurate results.

According to an embodiment of the present invention, there is provided an embodiment of a method of detecting a pulse wave propagation velocity should be noted that the steps illustrated in the flowchart drawings can be executed in a computer-executable instructions, such as a computer system in a group and, although in the flowchart shown in a logical order, but in some cases, the steps shown may be performed in a different order than or described herein.

FIG 5 is a flowchart of a method of detecting a pulse wave propagation velocity of the first embodiment of the present invention, shown in Figure 5, the method comprising the steps of:

Step S102, the detection signal generating circuit issues a predetermined frequency by the first signal.

S104, a first physiological signal detection signal by detecting a first predetermined signal frequency detection circuit after a first test position of the biological tissue carrying step.

Step S106, the physiological signal by the second detection signal a second signal detection circuit for detecting a predetermined frequency after the test biological tissue carrying a second position, wherein the first signal generating circuit and a first signal detection circuit constituting the first transceiver circuit The first signal generation circuit and the second signal detection circuit constituting the second transceiver circuit.

Step S108, the pulse wave velocity is determined in the test biological tissue in the physiological signal according to the first and second physiological signal.

By the above-described embodiments, using two transceiver circuit for detecting a physiological signal measured biological tissue carrying two positions to determine a pulse wave velocity in the biological tissue, determining the time difference is more accurate physiological signals, achieved through two the radio wave measuring channel pulse wave velocity in a physiological tissue technical effect more accurate, thereby solving the prior art Doppler effect detected by a pulse wave propagation velocity inaccurate results technical problems.

FIG 6 is a flowchart of a method of detecting a pulse wave propagation velocity to a second embodiment of the present invention, shown in Figure 6, the method comprising the steps of:

Step S202, the signal detection circuit to send a first predetermined frequency by generating a first signal.

Step S204, a first probe signal via a first physiological signal detection circuit detecting a first predetermined signal frequency after a first test biological tissue carrying position.

Step S206, the second detection signal generating circuit issues a predetermined frequency by a second signal.

Step S208, a second physiological signal by the second signal detection circuit detecting a second detection signal of a predetermined frequency after the test biological tissue carrying a second position, wherein the first signal generating circuit and a signal detecting circuit composed of a first first a transceiver circuit, a second signal generation circuit and the second signal detection circuit constituting the second transceiver circuit.

Step S210, the pulse wave velocity is determined in the test biological tissue in the physiological signal according to the first and second physiological signal.

By the above-described embodiments, using two transceiver circuit for detecting a physiological signal measured biological tissue carrying two positions to determine a pulse wave velocity in the biological tissue, determining the time difference is more accurate physiological signals, achieved through two the radio wave measuring channel pulse wave velocity in a physiological tissue technical effect more accurate, thereby solving the prior art Doppler effect detected by a pulse wave propagation velocity inaccurate results technical problems.

Comprising a processor core, the memory retrieved kernel to a respective program element. The kernel may be provided one or more calculated pulse wave propagation velocity by adjusting kernel parameters in physiological tissues.

The memory may include computer readable media in the volatile memory, a random access memory (RAM) and / or other forms of nonvolatile memory, such as read only memory (ROM) or flash memory (flash RAM), a memory comprising at least memory chips.

Example No. embodiment of the present invention are merely for description, and do not represent embodiments of the merits.

In the above embodiment of the present invention, the description of the various embodiments have different emphases, certain embodiments not detailed in part, be related descriptions in other embodiments.

Several embodiments of the present invention is provided in the embodiment, it should be understood that the disclosed technical content can be achieved in other manners. Wherein the apparatus embodiments described above are merely exemplary embodiments, for example, the dividing unit may be divided into a logical function, there may be other division in actual implementation, for example, a plurality of units or components may be combined or integrated into another system, or some features may be ignored or not performed. Another point, shown or discussed coupling or direct coupling or communication connection between each other may be indirectly coupled through, some interfaces or communication, units or modules are connected, may be electrical or other forms.

The unit is described as separated parts may be or may not be physically separate, parts displayed as units may be or may not be physical units, i.e. may be located in one place, or may be distributed to multiple units. You can select some or all of the units according to actual needs to achieve the object of the solutions of the embodiments.

Further, each of the functional units in the embodiments of the present invention may be integrated in one processing unit, separate units may be physically present, may be two or more units are integrated into one unit. The integrated unit may be implemented in the form of hardware, software functional units may also be implemented.

If the integrated unit is implemented as an independent product sold or used in the form of a software functional unit may be stored in a computer-readable storage medium. Based on such understanding, the technical solutions of the present invention essentially, or the part or all of the technical solutions contributing to the prior art may be embodied in part or in the form of a software product, which computer software product is stored in a storage medium , including several instructions for instructing a computer device to perform all or part of the steps of the method according to various embodiments of the present invention (may be a personal computer, server or network device). The storage medium includes: U disk, read only memory (ROM, Read-Only Memory), a random access various media may store program code memory (RAM, Random Access Memory), removable hard disk, a magnetic disk or optical disk .

The above are only preferred embodiments of the present invention, it should be noted that those of ordinary skill in the art, in the present invention without departing from the principles of the premise, can make various improvements and modifications, improvements and modifications are also It should be regarded as the protection scope of the present invention.

Industrial Applicability

Embodiment uses the detection signal emitted the predetermined frequency of the first signal generating circuit of the present invention; first physiological signal detection signal of the first predetermined frequency signal detection circuit detecting a first biological tissue measured after carrying position; a second signal detection circuit a second physiological signal detection signal detecting a predetermined frequency after the test biological tissue carrying a second position, wherein the first signal generating circuit and a first signal detection circuit constituting a first transceiver circuit, a first and a second signal generating circuit a second transceiver circuit signal detecting circuit; processor determines a pulse wave velocity measured in biological tissue in the physiological signal according to the first and second physiological signal. Two physiological signals measured positions of the biological tissue detected by transceiver circuitry carried by the two pulse wave velocity is determined in a physiological tissue, to more accurately determine the time difference between the physiological signal, a radio wave measurement realized by two pulse wave propagation velocity in a physiological tissue technical effect more accurate, thereby solving the prior art Doppler effect detected by a pulse wave propagation velocity inaccurate results technical problems.

Claims (10)

  1. One kind of pulse wave propagation velocity detector, comprising:
    A first signal generating circuit arranged to issue a detection signal of a predetermined frequency;
    A first signal detection circuit, a first detection signal to detect a physiological signal of the predetermined frequency after the first test biological tissue carrying position;
    Second signal detection circuit, a second detection signal to detect a physiological signal of the predetermined frequency after the test biological tissue carrying a second position, wherein the first signal generating circuit and a signal detecting circuit of the first constituting the first transceiver circuit, the first signal generation circuit and the second signal detection circuit constituting the second transceiver circuit;
    A processor arranged to determine a pulse wave based on the first physiological signal and the physiological signal in the second propagation speed measured in biological tissue.
  2. The probe according to claim 1, wherein,
    The first signal generating circuit comprises:
    F1 frequency generator, arranged to emit a detection signal of a frequency f1;
    F2 frequency generator, arranged to emit a detection signal of frequency f2;
    A first combiner connected to said generator frequency f1 and the frequency f2 generator arranged to detect the signal frequency f1 and the frequency f2 is the detection signal combiner, a first combined to give Road signal;
    A first transmitting antenna, connected to the first combiner, arranged to transmit the first combined signal, wherein said probe signal includes a predetermined frequency of said first signal combiner.
  3. The probe according to claim 2, wherein,
    The first signal detection circuit comprises:
    A first receiving antenna arranged to receive a first measured signal, wherein said first test signal carries the first physiological signal, the physiological signal for said first combined signal passes through the first biological tissue measured physiological signal generated by a first position;
    A first splitter, connected to the first receiving antenna, a frequency set according to the first test signal into two paths, a first measured signal to give a frequency f1 and a frequency f2 of the first test signal;
    First frequency f1 detector, connected to the first splitter, configured to detect the physiological signal is a first frequency f1 test signal carried in;
    A first frequency f2 detector, connected to the first splitter, configured to detect the physiological signal frequency f2 of the first test signal carried,
    Said second signal detection circuit comprises:
    A second receiving antenna arranged to receive a second test signal, wherein the second test signal carries a second physiological signal, the physiological signal for said second combined signal passes through the first biological tissue measured physiological signal generated by the second location;
    A second splitter, connected to the second receiving antenna, a frequency set according to the second test signal into two, a second frequency is measured to obtain a second measured signal frequency f1 and f2, signal;
    Second frequency f1 detector connected to the second splitter, the second set of physiological signals f1 test signal is carried in the detected frequency;
    The second frequency f2 detector connected to the second splitter, configured to detect the physiological signal frequency f2 of the second test signal carried.
  4. A probe according to claim 3, wherein,
    The processor is arranged according to the formula PWV = d / deltaT calculating the pulse wave velocity measured in the biological tissue in which, deltaT = (deltaT1 + deltaT2) / 2, deltaT1 for said first frequency f1 the frequency of the physiological signal detector detects a frequency f1 of a first test signal and the second carried frequency f1 detected by the detector as a second physiological signal of the test signal carried f1 delay difference, deltaT2 frequency f2 to the first detector detects the frequency of the first frequency of the physiological signal f2 test signal and the second carried frequency f2 is detected by the detector of the f2 two signal delay difference measured physiological signals carried, deltaT average value of delay difference, d is a distance between the first position and the second position, PWV of the pulse wave in the propagation speed measured in biological tissue.
  5. One kind of pulse wave propagation velocity detector, comprising:
    A first signal generating circuit arranged to issue a first detection signal of a predetermined frequency;
    A first signal detection circuit, a first physiological signal to detect a first detection signal after the predetermined frequency is measured biological tissue carrying a first position;
    Second signal generating circuit, arranged to issue a second detection signal of a predetermined frequency;
    Second physiological signal of the second signal detection circuit arranged to detect the second detection signal of a predetermined frequency after the test biological tissue carrying a second position, wherein said first signal generating circuit and said first signal a first transceiver circuit detection circuit, a second signal generating circuit and the second signal detection circuit constituting the second transceiver circuit;
    A processor arranged to determine a pulse wave based on the first physiological signal and the physiological signal in the second propagation speed measured in biological tissue.
  6. The probe according to claim 5, wherein,
    The first signal generating circuit comprises:
    F11 frequency generator, arranged to emit a detection signal of a frequency f11;
    Frequency f21 generator configured to emit a detection signal of a frequency f21;
    A first combiner connected to the generator frequencies f11 and f21 of the frequency generator, arranged to detect the signal frequency and the frequencies f11 and f21 is performed to detect a signal combiner, a first combined to give signals, wherein the first probe signal comprises a first predetermined frequency signal combiner;
    A first transmitting antenna, connected to the first combiner, arranged to transmit the first signal combiner,
    The first signal detection circuit comprises:
    A first receiving antenna arranged to receive a first measured signal, wherein said first test signal carries the first physiological signal, the physiological signal for said first combined signal passes through the first biological tissue measured physiological signal generated by a first position;
    A first splitter, connected to the first receiving antenna, as a first test signal into two paths, a first measured signal to obtain a frequency f11 and the frequency is measured in accordance with a first frequency f21 of the signal;
    F11 frequency detector, connected to the first splitter, configured to detect the physiological signal frequency f11 of the first test signal carried;
    Frequency f21 detector, connected to the first splitter, a first set of physiological signals to detect a test signal of the frequency f21 is carried.
  7. The probe according to claim 6, wherein,
    The second signal generating circuit comprises:
    F12 frequency generator, arranged to emit a detection signal of frequency f12;
    F22 frequency generator, arranged to emit a detection signal of a frequency f22;
    A second combiner, connected to the generator frequency f12 and f22 of the frequency generator, arranged to detect a frequency of the frequency signal and the detection signal f22 f12 is performing combination to obtain a second co channel signal, wherein said second probe signal comprises said second predetermined frequency signal combiner;
    A second transmit antenna, connected to the second combiner, arranged to transmit the second signal combiner,
    Said second signal detection circuit comprises:
    A second receiving antenna arranged to receive a second test signal, wherein the second test signal carries a second physiological signal, the physiological signal for said second combined signal through the second biological tissue measured physiological signal generated by a second position;
    A second splitter, connected to the second receiving antenna, a frequency set according to the second test signal into two paths, a first measured signal to obtain a frequency f12 and frequency f22 of the first test signal;
    F12 frequency detector, connected to the second splitter, configured to detect the physiological signal frequency f12 of the second test signal carried;
    F22 frequency detector, connected to the second splitter, configured to detect the physiological signal frequency f22 of the second test signal carried.
  8. The probe according to claim 7, wherein,
    The processor is arranged according to the formula PWV = d / deltaT calculates the pulse wave velocity measured in the biological tissue in which, deltaT = (deltaT1 + deltaT2) / 2, deltaT1 frequency f11 of the detector detected the frequency f11 of the signal to be measured is first carried in the physiological signal and the frequency f12 delay detector detects a second difference signal to be measured physiological signal f12 is carried in, deltaT2 is said frequency detector detects the frequency f21 to f21 of the first test signal carried in the physiological signal and the frequency detector detects the frequency f22 to f22 is a physiological signal of the second test carried delay difference signal, deltaT average value of delay difference, d is a distance between the first position and the second position, PWV is a propagation velocity of the pulse wave measured in the physiological tissue .
  9. A method of detecting a pulse wave propagation velocity, comprising:
    It generates a detection signal by a predetermined frequency, a first signal generating circuit;
    First physiological signal detection circuit detects a signal by detecting a first signal of the predetermined frequency after the first test biological tissue carrying position;
    Second physiological signal detection circuit detects a signal by the detection signal of said second predetermined frequency after the test biological tissue carrying a second position, wherein the first signal generating circuit and a signal detecting circuit composed of the first section a transceiver circuit, a first signal generation circuit and the second signal detection circuit constituting the second transceiver circuit;
    The first and second physiological signal to determine physiological signal in the pulse wave velocity measured in accordance with the physiological tissue.
  10. A method of detecting a pulse wave propagation velocity, comprising:
    A first detection signal emitted by a first predetermined frequency signal generating circuit;
    A first probe signal via a first physiological signal detection circuit detecting a first signal of the predetermined frequency after the first test biological tissue carrying position;
    Detecting a second predetermined frequency of the signal emitted second signal generation circuit;
    A second detection signal by a second physiological signal detection circuit detects a second signal after said predetermined frequency is measured biological tissue carrying a second position, wherein the first signal generating circuit and a signal detecting circuit of the first constituting the first transceiver circuit, a second signal generating circuit and the second signal detection circuit constituting the second transceiver circuit;
    The first and second physiological signal to determine the physiological signal in the pulse wave velocity measured in accordance with physiological tissue.
PCT/CN2017/072777 2017-01-26 2017-01-26 Detector and detection method for pulse wave propagation velocity WO2018137251A1 (en)

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CN1787777A (en) * 2003-04-08 2006-06-14 联邦科学和工业研究组织 Microwave based monitoring system and method
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