WO2018137251A1

WO2018137251A1 - Detector and detection method for pulse wave propagation velocity

Info

Publication number: WO2018137251A1
Application number: PCT/CN2017/072777
Authority: WO
Inventors: 王尧; 陈驰; 朱宇东
Original assignee: 悦享趋势科技（北京）有限责任公司
Priority date: 2017-01-26
Filing date: 2017-01-26
Publication date: 2018-08-02

Abstract

A detector and detection method for a pulse wave propagation velocity. The detector comprises: a first signal generation circuit (10) used to send out a detection signal having a predetermined frequency; a first signal detection circuit (20) used to detect a first physiological signal carried in a detection signal having the predetermined frequency after the detection signal passes through a tissue under test at a first position; a second signal detection circuit (30) used to detect a second physiological signal carried in a detection signal after the detection signal passes through the tissue under test at a second position, wherein the first signal generation circuit (10) and the first signal detection circuit (20) form a first transceiving circuit, and the first signal generation circuit (10) and the second signal detection circuit (30) form a second transceiving circuit; and a processor (40) used to determine, according to the first physiological signal and the second physiological signal, a pulse wave propagation velocity in the tissue under test. The detector solves the technical problem of inaccuracy in the prior art in which a pulse wave propagation velocity is detected by means of the Doppler effect.

Description

Pulse wave propagation velocity detector and detection method

Technical field

The present invention relates to the field of detection, and in particular to a detector and method for detecting pulse wave velocity.

Background technique

The detection of the pulse wave velocity in an organism is of great significance for the diagnosis of the health status of the organism. For example, intravascular blood flow velocity and blood flow have certain value for the diagnosis of cardiovascular diseases, especially for the circulation process. Oxygen conditions, atresia, turbulence, atherosclerosis, etc. can provide valuable diagnostics.

In the prior art, in order to check the movement state of the heart and blood vessels, understanding the blood flow velocity can be achieved by transmitting ultrasound. Since the blood in the blood vessel is a flowing object, a Doppler effect is generated between the ultrasonic vibration source and the relatively moving blood. When the blood moves toward the ultrasonic source, the wavelength of the reflected wave is compressed, and thus the frequency is increased. When the blood leaves the super-source movement, the wavelength of the reflected wave becomes longer and the frequency becomes smaller. The amount by which the frequency of the reflected wave is increased or decreased is proportional to the flow velocity of the blood, so that the flow rate of the blood can be measured based on the amount of frequency shift of the ultrasonic wave.

However, the signal detected by the Doppler effect detection method is very weak and susceptible to interference, so the test result is inaccurate, and the Pulse Wave Velocity (PWV) device is complicated and expensive. Professionals operate, not portable. If other pressure sensors are used for measurement, it is inconvenient to operate because of the need to measure distances and require assistance from others.

In response to the above problems, no effective solution has been proposed yet.

Summary of the invention

The embodiment of the invention provides a detector and a detection method for pulse wave propagation velocity, so as to at least solve the technical problem that the propagation velocity result of the pulse wave is not accurately detected by the Doppler effect in the prior art.

According to an aspect of an embodiment of the present invention, a probe for a pulse wave propagation speed is provided, comprising: a first signal generating circuit for emitting a sounding signal of a predetermined frequency; and a first signal detecting circuit for detecting the predetermined a first physiological signal carried by the frequency detecting signal after passing through the physiological tissue to be tested in the first position; and a second signal detecting circuit, configured to detect that the detecting signal of the predetermined frequency is carried after passing through the physiological tissue to be tested in the second position a second physiological signal, wherein the first signal generating circuit and the first signal detecting circuit constitute a first transceiver circuit, and the first signal generating circuit and the second signal detecting circuit constitute a second transceiver circuit; And determining, according to the first physiological signal and the second physiological signal, a propagation speed of the pulse wave in the physiological tissue to be tested.

In the embodiment of the present invention, the first signal generating circuit includes: a frequency f1 generator for emitting a detection signal with a frequency of f1; a frequency f2 generator for emitting a detection signal with a frequency of f2; And the frequency f1 generator and the frequency f2 generator are connected to combine the detection signal of the frequency f1 and the detection signal of the frequency f2 to obtain a first combined signal; a transmitting antenna coupled to the first combiner for transmitting the first combined signal, wherein the predetermined frequency detection signal comprises the first combined signal.

In the embodiment of the present invention, the first signal detecting circuit includes: a first receiving antenna, configured to receive a first signal to be tested, where the first signal to be tested carries the first physiological signal, The first physiological signal is a physiological signal generated by the first combined signal passing through the physiological tissue to be tested at the first position; and the first splitter is connected to the first receiving antenna for using the frequency according to the frequency The first signal to be tested is divided into two paths to obtain a first signal to be tested having a frequency of f1 and a first signal to be measured having a frequency of f2; a first frequency f1 detector connected to the first splitter for Detecting a physiological signal carried in the first signal to be tested with the frequency f1; a first frequency f2 detector connected to the first splitter for detecting the first signal to be tested with the frequency f2 The second signal detecting circuit includes: a second receiving antenna, configured to receive a second signal to be tested, wherein the second signal to be tested carries the second physiological signal, The second physiological signal is the first combined signal passing through the a physiological signal generated by the physiological tissue to be tested in the second position; a second splitter connected to the second receiving antenna, configured to divide the second signal to be tested into two paths according to a frequency, to obtain a frequency of f1 a second signal to be measured and a second signal to be measured having a frequency of f2; a second frequency f1 detector connected to the second splitter for detecting a physiological condition carried in the second signal to be tested having the frequency f1 a second frequency f2 detector connected to the second splitter for detecting a physiological signal carried in the second signal to be tested having the frequency f2.

In the embodiment of the present invention, the processor is configured to calculate a propagation speed of the pulse wave in the physiological tissue to be tested according to the formula PWV=d/deltaT, where deltaT=(deltaT1+deltaT2)/2, and deltaT1 is the first a physiological signal carried in the first signal to be tested whose frequency is f1 detected by the frequency f1 detector and a physiological signal carried in the second signal to be measured detected in the frequency f1 detected by the second frequency f1 detector a delay difference, deltaT2 is a physiological signal carried in the first signal to be tested whose frequency is f2 detected by the first frequency f2 detector, and the frequency detected by the second frequency f2 detector is f2 The delay difference of the physiological signal carried in the second signal to be tested, deltaT is the average value of the delay difference, d is the distance between the first position and the second position, and PWV is the pulse wave The speed of propagation in the physiological tissue to be tested.

According to another aspect of the embodiments of the present invention, a probe for pulse wave velocity is further provided, comprising: a first signal generating circuit for emitting a first detecting signal of a predetermined frequency; and a first signal detecting circuit for Check Measuring a first physiological signal carried by the first detection signal of the predetermined frequency after passing through the physiological tissue to be tested at the first position; a second signal generating circuit for emitting a second detection signal of a predetermined frequency; and a second signal detecting circuit, a second physiological signal carried by the second detection signal for detecting the predetermined frequency after passing through the physiological tissue to be tested at the second position, wherein the first signal generation circuit and the first signal detection circuit constitute a first transmission and reception The second signal generating circuit and the second signal detecting circuit constitute a second transceiver circuit; the processor is configured to determine, according to the first physiological signal and the second physiological signal, a pulse wave in the to-be-tested The speed of propagation in physiological tissues.

In the embodiment of the present invention, the first signal generating circuit includes: a frequency f11 generator for emitting a detection signal with a frequency of f11; a frequency f21 generator for emitting a detection signal with a frequency of f21; And the frequency f11 generator and the frequency f21 generator are connected to combine the detection signal of the frequency f11 and the detection signal of the frequency f21 to obtain a first combined signal, wherein The first detecting signal of the predetermined frequency includes the first combining signal; the first transmitting antenna is connected to the first combiner for transmitting the first combined signal, the first signal The detecting circuit includes: a first receiving antenna, configured to receive a first signal to be tested, wherein the first signal to be tested carries the first physiological signal, and the first physiological signal is the first combined signal a physiological signal generated by the signal passing through the physiological tissue to be tested in the first position; a first splitter connected to the first receiving antenna, configured to divide the first signal to be tested into two paths according to a frequency, to obtain a frequency The first test for f11 And a first signal to be measured having a frequency of f21; a frequency f11 detector connected to the first splitter for detecting a physiological signal carried in the first signal to be tested having the frequency f11; detecting the frequency f21 And connected to the first splitter, configured to detect a physiological signal carried in the first signal to be tested of the frequency f21.

In the embodiment of the present invention, the second signal generating circuit includes: a frequency f12 generator for emitting a detecting signal with a frequency of f12; a frequency f22 generator for emitting a detecting signal with a frequency of f22; and a second combining circuit And the frequency f12 generator and the frequency f22 generator are connected to combine the detection signal of the frequency f12 and the detection signal of the frequency f22 to obtain a second combined signal, wherein The second detecting signal of the predetermined frequency includes the second combining signal; the second transmitting antenna is connected to the second combiner for transmitting the second combined signal, the second signal The detecting circuit includes: a second receiving antenna, configured to receive a second signal to be tested, wherein the second signal to be tested carries the second physiological signal, and the second physiological signal is the second combined signal Transmitting a physiological signal generated by the physiological tissue to be tested in the second position; the second splitter is connected to the second receiving antenna, and configured to divide the second signal to be tested into two paths according to a frequency to obtain a frequency The first test for f12 a first signal to be measured with a frequency of f22; a frequency f12 detector connected to the second splitter for detecting a physiological signal carried in the second signal to be tested having the frequency f12; detecting the frequency f22 And connected to the second splitter, configured to detect a physiological signal carried in the second signal to be tested of the frequency f22.

In the embodiment of the present invention, the processor is configured to calculate a propagation speed of the pulse wave in the physiological tissue to be tested according to the formula PWV=d/deltaT, where deltaT=(deltaT1+deltaT2)/2, and deltaT1 is the frequency f11. The difference between the physiological signal carried in the first signal to be tested and the physiological signal carried in the second signal to be measured, which is detected by the frequency f12 detector, is detected by the detector. The deltaT2 is carried by the physiological signal carried in the first signal to be tested whose frequency is f21 detected by the frequency f21 detector and the second signal to be tested whose frequency is f22 detected by the frequency f22 detector The delay difference of the physiological signal, deltaT is the average value of the delay difference, d is the distance between the first position and the second position, and PWV is the pulse wave in the physiological tissue to be tested transmission speed.

According to another aspect of the embodiments of the present invention, there is provided a method for detecting a pulse wave propagation speed, comprising: transmitting a detection signal of a predetermined frequency by a first signal generation circuit; and detecting the predetermined frequency by a first signal detection circuit a first physiological signal carried by the detection signal after passing through the physiological tissue to be tested at the first position; and detecting, by the second signal detecting circuit, the second physiological signal carried by the detection signal of the predetermined frequency after passing through the physiological tissue to be tested at the second position, The first signal generating circuit and the first signal detecting circuit constitute a first transceiver circuit, and the first signal generating circuit and the second signal detecting circuit constitute a second transceiver circuit; according to the first physiological The signal and the second physiological signal determine a velocity of propagation of the pulse wave in the physiological tissue to be measured.

According to another aspect of the embodiments of the present invention, there is also provided a method for detecting a pulse wave propagation speed, comprising: transmitting a first detection signal of a predetermined frequency by a first signal generation circuit; and detecting the predetermined by a first signal detection circuit a first physiological signal carried by the first detection signal of the frequency after passing through the physiological tissue to be tested at the first position; a second detection signal of a predetermined frequency is emitted by the second signal generating circuit; and detecting the predetermined frequency by the second signal detecting circuit a second physiological signal carried by the second detecting signal after passing through the physiological tissue to be tested in the second position, wherein the first signal generating circuit and the first signal detecting circuit constitute a first transceiver circuit, and the second signal occurs The circuit and the second signal detecting circuit constitute a second transceiver circuit; and determining a propagation speed of the pulse wave in the physiological tissue to be tested according to the first physiological signal and the second physiological signal.

In the embodiment of the present invention, the first signal generating circuit is configured to generate a detection signal of a predetermined frequency; the first signal detecting circuit detects a first physiological signal carried by the detection signal of the predetermined frequency after passing through the physiological tissue to be tested at the first position; The signal detecting circuit detects a second physiological signal carried by the detection signal of the predetermined frequency after passing through the physiological tissue to be tested in the second position, wherein the first signal generating circuit and the first signal detecting circuit constitute a first transceiver circuit, and the first signal generating circuit And the second signal detecting circuit constitutes a second transceiver circuit; the processor determines the propagation speed of the pulse wave in the physiological tissue to be tested according to the first physiological signal and the second physiological signal. The physiological signals carried by the physiological tissues to be tested at two positions detected by the two transceiver circuits determine the propagation speed of the pulse wave in the physiological tissue, and the time difference of the physiological signals is more accurately determined, and the pulse is measured by two radio waves. The technical effect of the wave propagation speed in the physiological tissue is more accurate, and the technical problem of detecting the inaccurate result of the pulse wave propagation speed by the Doppler effect in the prior art is solved.

DRAWINGS

The drawings described herein are intended to provide a further understanding of the invention, and are intended to be a part of the invention. In the drawing:

1 is a schematic view of a probe for pulse wave velocity according to a first embodiment of the present invention;

Figure 2 is a schematic illustration of a probe for pulse wave velocity in accordance with a second embodiment of the present invention;

Figure 3 is a schematic illustration of a probe for pulse wave velocity in accordance with a third embodiment of the present invention;

Figure 4 is a schematic illustration of a probe for pulse wave velocity in accordance with a fourth embodiment of the present invention;

FIG. 5 is a flowchart of a method for detecting a pulse wave propagation speed according to a first embodiment of the present invention;

Fig. 6 is a flow chart showing a method of detecting a pulse wave propagation speed according to a second embodiment of the present invention.

detailed description

The technical solutions in the embodiments of the present invention are clearly and completely described in the following with reference to the accompanying drawings in the embodiments of the present invention. It is an embodiment of the invention, but not all of the embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative efforts shall fall within the scope of the present invention.

It is to be understood that the terms "first", "second" and the like in the specification and claims of the present invention are used to distinguish similar objects, and are not necessarily used to describe a particular order or order. It is to be understood that the data so used may be interchanged where appropriate, so that the embodiments of the invention described herein can be implemented in a sequence other than those illustrated or described herein. In addition, the terms "comprises" and "comprises" and "the" and "the" are intended to cover a non-exclusive inclusion, for example, a process, method, system, product, or device that comprises a series of steps or units is not necessarily limited to Those steps or units may include other steps or units not explicitly listed or inherent to such processes, methods, products or devices.

First, the technical terms involved in the embodiments of the present application are explained as follows:

Pulse wave: The pulse wave is formed by the heart's pulsation (vibration) propagating along the arterial blood vessels and blood flow to the periphery. Therefore, the speed of propagation depends on the physical and geometric properties of the propagation medium, for example, the elasticity of the artery, the size of the lumen, The density and viscosity of the blood, etc., are particularly closely related to the elasticity, caliber and thickness of the arterial wall.

In accordance with an embodiment of the invention, a detector for pulse wave velocity is provided. 1 is a schematic view of a probe for pulse wave velocity according to a first embodiment of the present invention, as shown in FIG. 1, the detector includes the following components section:

The first signal generating circuit 10 is configured to emit a detection signal of a predetermined frequency.

The first signal detecting circuit 20 is configured to detect a first physiological signal carried by the detecting signal of the predetermined frequency after passing through the physiological tissue to be tested at the first position.

The second signal detecting circuit 30 is configured to detect a second physiological signal carried by the detecting signal of the predetermined frequency after passing through the physiological tissue to be tested in the second position, wherein the first signal generating circuit and the first signal detecting circuit constitute the first transmitting and receiving circuit The first signal generating circuit and the second signal detecting circuit constitute a second transmitting and receiving circuit.

The processor 40 is configured to determine, according to the first physiological signal and the second physiological signal, a propagation speed of the pulse wave in the physiological tissue to be tested.

The processor 40 may be a separate module, or may be built in the first signal detecting circuit or the second signal detecting circuit. The processor may be one or two. If the processor is one, the processor may receive the first. The signal detecting circuit and the second signal detecting circuit detect the obtained data of the first physiological signal and the second physiological signal, and then perform processing. If the processor is two, one of the first physiological signals detected by the first signal detecting circuit is processed. The signal, the other processing the second physiological signal detected by the second signal detecting circuit, the connection manner of the processor in the detector can be flexible and diverse, and is not limited to a specific connection manner.

In the embodiment of the present invention, the first signal generating circuit includes: a frequency f1 generator for emitting a detection signal of frequency f1; a frequency f2 generator for emitting a detection signal of frequency f2; a first combiner, Connected to the frequency f1 generator and the frequency f2 generator for combining the detection signal of frequency f1 and the detection signal of frequency f2 to obtain a first combined signal; the first transmitting antenna and the first combiner Connected for transmitting a first combined signal, wherein the predetermined frequency of the detected signal comprises a first combined signal.

In the embodiment of the present invention, the first signal detecting circuit includes: a first receiving antenna, configured to receive the first signal to be tested, where the first signal to be tested carries the first physiological signal, and the first physiological signal is the first The combined signal passes through the physiological signal generated by the physiological tissue to be tested at the first position; the first splitter is connected to the first receiving antenna, and is configured to divide the first signal to be tested into two according to the frequency, and obtain the first frequency of f1. a first signal to be measured and a first signal to be measured having a frequency of f2; a first frequency f1 detector connected to the first splitter for detecting a physiological signal carried in the first signal to be tested having a frequency of f1; The frequency f2 detector is connected to the first splitter and is configured to detect the physiological signal carried in the first signal to be tested having the frequency f2.

The second signal detecting circuit includes: a second receiving antenna, configured to receive the second signal to be tested, wherein the second signal to be tested carries the second physiological signal, and the second physiological signal is the first combined signal passing through the second position The physiological signal generated by the physiological tissue to be tested; the second splitter is connected to the second receiving antenna, and is configured to divide the second signal to be tested into two according to the frequency, and obtain the second signal to be tested and the frequency of the frequency f1 is The second signal to be tested of f2; second The frequency f1 detector is connected to the second splitter for detecting the physiological signal carried in the second signal to be tested with the frequency f1; the second frequency f2 detector is connected with the second splitter for detecting the frequency The physiological signal carried in the second signal to be tested of f2.

In the embodiment of the present invention, the processor is configured to calculate a propagation speed of the pulse wave to be tested in the physiological tissue to be tested according to the formula PWV=d/deltaT, where deltaT=(deltaT1+deltaT2)/2, and deltaT1 is the first frequency f1. The physiological signal carried in the first signal to be tested whose frequency is detected by the detector is the delay difference of the physiological signal carried in the second signal to be detected detected by the second frequency f1 detector, and the deltaT2 is The physiological signal carried in the first signal to be tested whose frequency is f2 detected by the first frequency f2 detector and the time delay of the physiological signal carried in the second signal to be detected detected by the second frequency f2 detector Poor, deltaT is the average of the delay difference, d is the distance between the first position and the second position, and PWV is the propagation speed of the pulse wave in the physiological tissue to be tested. For example, the first position and the second position are both mounted on the user's arm, the distance between the first position and the second position, the physiological tissue to be tested may be blood, or other tissue fluid, etc., to be tested for physiological The tissue is blood. For example, during a systole, a part of the blood flows from the first position to the second position. There is a delay between the issuance of the first detection signal and the receipt of the signal to be tested, and the two detectors are detected. The delay difference can be used to obtain the delay difference. The average of the delay difference can be obtained by averaging the two delay differences. The pulse wave can be calculated in the blood according to the average of the delay difference and the distance between the two positions. transmission speed.

In the embodiment of the present invention, in addition to the single-issue and dual-receiving embodiments, more receiving circuits, such as single-issue and quad-receiving, or single-transmitting and six-receiving, may be adopted, and in view of convenient wearability and computational complexity in practical applications, The embodiment of the invention provides a detection structure for single-shot and double-receiving.

The embodiment of the present invention further provides a preferred embodiment, which is a preferred embodiment of the first embodiment described above, and FIG. 2 is a schematic diagram of a probe for pulse wave velocity according to a second embodiment of the present invention, such as As shown in Figure 2, the detector includes the following components:

The frequency f1 generator 710 generates a detection signal of frequency f1, the frequency f2 generator 720 generates a detection signal of frequency f2, and the detection signal of f1 and the detection signal of f2 are combined by the first combiner 620, and the transmitting antenna is 520 is launched.

The receiving antenna 510 receives the f1 signal and the f2 signal after the biological tissue motion disturbance, and after the first splitter 610 branches, the frequency f1 detector 810 detects the physiological signal w11 carried by f1, and the frequency f2 detector 820 detects the f2. The physiological signal w21 carried.

The receiving antenna 530 receives the f1 signal and the f2 signal after the biological tissue motion disturbance, and after the second splitter 630 branches, the frequency f1 detector 830 detects the physiological signal w12 carried by f1, and the frequency f2 detector 840 detects the f2. The physiological signal w22 carried.

Comparing the w11 signal with the w12 signal, a delay difference deltaT1 of the two signals can be obtained.

Comparing the w21 signal with the w22 signal, a delay difference deltaT2 of the two signals can be obtained.

Then the average delay of the two paths is deltaT=(deltaT1+deltaT2)/2.

Since the spacing d is known, then PWV = d / deltaT. Among them, PWV can indicate the propagation speed of the pulse wave.

PWV measurements can be made more accurate by averaging multiple measurements using n sets of frequencies and then averaging deltaTn to eliminate some accidental and unexpected interference.

3 is a schematic diagram of a probe for pulse wave velocity according to a third embodiment of the present invention. As shown in FIG. 3, the detector includes the following components:

The first signal generating circuit 11 is configured to emit a first detecting signal of a predetermined frequency; the first signal detecting circuit 21 is configured to detect a first physiological signal carried by the first detecting signal of the predetermined frequency after passing through the physiological tissue to be tested at the first position a signal; a second signal generating circuit 12 for transmitting a second detecting signal of a predetermined frequency; and a second signal detecting circuit 22 for detecting a second detecting signal of the predetermined frequency after being carried by the physiological tissue to be tested at the second position a physiological signal, wherein the first signal generating circuit and the first signal detecting circuit constitute a first transceiver circuit, the second signal generating circuit and the second signal detecting circuit constitute a second transceiver circuit; and the processor 40 is configured to perform according to the first physiological The signal and the second physiological signal determine the speed of propagation of the pulse wave in the physiological tissue to be tested.

The frequency of the detection signal sent by the first signal generating circuit may be the same as or different from the frequency of the detection signal sent by the second signal generating circuit.

The processor 40 may be a separate module, or may be integrated in a module with the first frequency detector or the second frequency detector. If the processor is a separate module, the processor and the frequency detector may be connected through a wireless network or Bluetooth and other ways to achieve data communication.

In the embodiment of the present invention, the first signal generating circuit 11 includes: a frequency f11 generator for emitting a detection signal of frequency f11; a frequency f21 generator for emitting a detection signal of frequency f21; the first combiner And connecting the frequency f11 generator and the frequency f21 generator for combining the detection signal of frequency f11 and the detection signal of frequency f21 to obtain a first combined signal, wherein the first detection signal of the predetermined frequency includes a first combining signal; the first transmitting antenna is connected to the first combiner for transmitting the first combined signal.

In the embodiment of the present invention, the first signal detecting circuit 21 includes: a first receiving antenna, configured to receive a first signal to be tested, where the first signal to be tested carries a first physiological signal, and the first physiological signal is The first signal is connected to the first receiving antenna for splitting the first signal to be measured according to the frequency, and the frequency is f11. The first signal to be tested and the frequency are f21 The first signal to be tested; the frequency f11 detector is connected to the first splitter for detecting the physiological signal carried in the first signal to be tested having the frequency f11; the frequency f21 detector is connected to the first splitter And for detecting a physiological signal carried in the first signal to be tested having a frequency of f21.

In the embodiment of the present invention, the second signal generating circuit 12 includes: a frequency f12 generator for emitting a detection signal having a frequency of f12; a frequency f22 generator for emitting a detection signal having a frequency of f22; and a second combiner And the frequency f12 generator and the frequency f22 generator are connected to combine the detection signal of the frequency f12 and the detection signal of the frequency f22 to obtain a second combined signal, wherein the second detection signal of the predetermined frequency includes a second combining signal; the second transmitting antenna is connected to the second combiner for transmitting the second combined signal.

The second signal detecting circuit 22 includes: a second receiving antenna, configured to receive a second signal to be tested, wherein the second signal to be tested carries a second physiological signal, and the second physiological signal is a second combined signal The physiological signal generated by the physiological tissue to be tested at the position; the second splitter is connected to the second receiving antenna, and is configured to divide the second signal to be tested into two according to the frequency, and obtain the first signal to be tested and the frequency with the frequency of f12. Is the first signal to be tested of f22; the frequency f12 detector is connected to the second splitter for detecting the physiological signal carried in the second signal to be tested having the frequency f12; the frequency f22 detector, and the second branch The device is connected to detect a physiological signal carried in the second signal to be tested having a frequency of f22.

In the embodiment of the present invention, the processor 40 is configured to calculate the propagation speed of the pulse wave in the physiological tissue to be tested according to the formula PWV=d/deltaT, wherein deltaT=(deltaT1+deltaT2)/2, deltaT1 is the frequency f11 detector The detected physiological frequency signal carried in the first signal to be tested of frequency f11 and the delay difference of the physiological signal carried in the second signal to be detected detected by the frequency f12 detector is f12, and the deltaT2 is the frequency f21 detector The detected physiological signal carried in the first signal to be tested of frequency f21 and the delay difference of the physiological signal carried in the second signal to be detected detected by the frequency f22 detector at frequency f22, deltaT is the delay difference The average value, d is the distance between the first position and the second position, and PWV is the propagation speed of the pulse wave.

The embodiment of the present invention further provides a preferred embodiment, which is a preferred embodiment of the third embodiment described above, and FIG. 4 is a schematic diagram of a probe for pulse wave propagation speed according to a fourth embodiment of the present invention, such as As shown in Figure 4, the detector includes the following components:

The frequency f11 generator 310 generates a detection frequency f11, and the frequency f21 generator 320 generates a detection frequency f21, which is transmitted from the transmitting antenna 120 after being combined by the first combiner 220. The receiving antenna 110 receives the f11 signal and the f21 signal after the biological tissue motion disturbance, and after the first splitter 210 branches, the frequency f11 detector 410 detects the physiological signal w11 carried by the f11, and the frequency f21 detector 420 detects the f21. The physiological signal w21 carried.

The frequency f12 generator 330 generates a detection frequency f12, and the frequency f22 generator 340 generates a detection frequency f22, After f12 and f22 are combined by the second combiner 230, they are transmitted from the transmitting antenna two 130. The receiving antenna 214 receives the f12 signal and the f22 signal after the biological tissue motion disturbance, and after the second splitter 240 branches, the frequency f12 detector 430 detects the physiological signal w12 carried by the f12, and the frequency f22 detector 440 detects the f22. The physiological signal w22 carried.

Then the average delay of the two paths is deltaT=(deltaT1+deltaT2)/2.

In the embodiment of the present invention, in addition to the dual-issue and dual-receiving embodiments, more receiving circuits, such as four-four-four-receiving, or six-six-six-receiving, etc., may be used in consideration of practical wear and computational complexity. The embodiment of the invention provides a detection structure for double-shot and double-receiving.

The technical solution of the embodiment of the invention can use the radio wave sensor to measure the pulse wave, the non-invasive method, the operation is simple, and the belt can be measured on the wrist without assistance from others. The technical problem of finding the time difference of the measurement time due to the characteristics of the circuit and the characteristics of the pulse is solved. The present invention uses a plurality of sets of frequencies to measure the PWV, and each set of frequencies is composed of one or a pair of frequencies. Each group of frequencies can get a time difference deltaTn, where n is the nth group of frequencies. Since PWV is constant during measurement, the distance d of the two sets of receiving antennas is constant, so PWV = d / deltaT, and deltaT is the average of n sets of deltaTn. For more accurate results.

In accordance with an embodiment of the present invention, an embodiment of a method of detecting pulse wave velocity is provided, and it is noted that the steps illustrated in the flowchart of the drawings may be performed in a computer system such as a set of computer executable instructions. And, although the logical order is shown in the flowcharts, in some cases the steps shown or described may be performed in a different order than the ones described herein.

FIG. 5 is a flowchart of a method for detecting a pulse wave propagation speed according to a first embodiment of the present invention. As shown in FIG. 5, the method includes the following steps:

Step S102, the detection signal of the predetermined frequency is sent by the first signal generating circuit.

Step S104, detecting, by the first signal detecting circuit, the first physiological signal carried by the detection signal of the predetermined frequency after passing through the physiological tissue to be tested at the first position.

Step S106, detecting, by the second signal detecting circuit, a second physiological signal carried by the detection signal of the predetermined frequency after passing through the physiological tissue to be tested in the second position, wherein the first signal generating circuit and the first signal detecting circuit constitute the first transmitting and receiving circuit The first signal generating circuit and the second signal detecting circuit constitute a second transmitting and receiving circuit.

Step S108, determining a propagation speed of the pulse wave in the physiological tissue to be tested according to the first physiological signal and the second physiological signal.

Through the above embodiment, the physiological signals carried by the physiological tissue to be tested at two positions detected by the two transceiver circuits are used to determine the propagation speed of the pulse wave in the physiological tissue, and the time difference of the physiological signal is determined more accurately, and the two The road radio wave measures the technical effect of the pulse wave propagation speed in the physiological tissue, and further solves the technical problem that the propagation speed of the pulse wave is inaccurate by the Doppler effect in the prior art.

FIG. 6 is a flowchart of a method for detecting a pulse wave propagation speed according to a second embodiment of the present invention. As shown in FIG. 6, the method includes the following steps:

Step S202, the first detection signal of the predetermined frequency is sent by the first signal generating circuit.

Step S204, detecting, by the first signal detecting circuit, the first physiological signal carried by the first detecting signal of the predetermined frequency after passing through the physiological tissue to be tested at the first position.

Step S206, the second detection signal of the predetermined frequency is sent by the second signal generating circuit.

Step S208, detecting, by the second signal detecting circuit, the second physiological signal carried by the second detecting signal of the predetermined frequency after passing through the physiological tissue to be tested in the second position, wherein the first signal generating circuit and the first signal detecting circuit form a first The transceiver circuit, the second signal generating circuit and the second signal detecting circuit constitute a second transceiver circuit.

Step S210, determining a propagation speed of the pulse wave in the physiological tissue to be tested according to the first physiological signal and the second physiological signal.

The processor contains a kernel, and the kernel removes the corresponding program unit from the memory. The kernel can set one or more, and adjust the kernel parameters to calculate the propagation speed of the pulse wave in the physiological tissue.

The memory may include non-persistent memory, random access memory (RAM), and/or non-volatile memory in a computer readable medium, such as read only memory (ROM) or flash memory (flash RAM), the memory including at least one Memory chip.

The serial numbers of the embodiments of the present invention are merely for the description, and do not represent the advantages and disadvantages of the embodiments.

In the above-mentioned embodiments of the present invention, the descriptions of the various embodiments are different, and the parts that are not detailed in a certain embodiment can be referred to the related descriptions of other embodiments.

In the several embodiments provided by the present invention, it should be understood that the disclosed technical contents may be implemented in other manners. The device embodiments described above are only schematic. For example, the division of the unit may be a logical function division. In actual implementation, there may be another division manner, for example, multiple units or components may be combined or may be Integrate into another system, or some features can be ignored or not executed. In addition, the mutual coupling or direct coupling or communication connection shown or discussed may be an indirect coupling or communication connection through some interface, unit or module, and may be electrical or otherwise.

The units described as separate components may or may not be physically separated, and the components displayed as units may or may not be physical units, that is, may be located in one place, or may be distributed to multiple units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of the embodiment.

In addition, each functional unit in each embodiment of the present invention may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above integrated unit can be implemented in the form of hardware or in the form of a software functional unit.

The integrated unit, if implemented in the form of a software functional unit and sold or used as a standalone product, may be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present invention, which is essential or contributes to the prior art, or all or part of the technical solution, may be embodied in the form of a software product stored in a storage medium. A number of instructions are included to cause a computer device (which may be a personal computer, server or network device, etc.) to perform all or part of the steps of the methods described in various embodiments of the present invention. The foregoing storage medium includes: a U disk, a Read-Only Memory (ROM), a Random Access Memory (RAM), a removable hard disk, a magnetic disk, or an optical disk, and the like. .

The above description is only a preferred embodiment of the present invention, and it should be noted that those skilled in the art can also make several improvements and retouchings without departing from the principles of the present invention. It should be considered as the scope of protection of the present invention.

Industrial applicability

The first signal generating circuit detects the detection signal of the predetermined frequency by using the first signal generating circuit; the first signal detecting circuit detects the first physiological signal carried by the detecting signal of the predetermined frequency after passing through the physiological tissue to be tested at the first position; The second signal detecting circuit detects a second physiological signal carried by the detecting signal of the predetermined frequency after passing through the physiological tissue to be tested in the second position, wherein the first signal generating circuit and the first signal detecting circuit form a first transmitting and receiving circuit, the first signal The generating circuit and the second signal detecting circuit constitute a second transceiver circuit; the processor determines the propagation speed of the pulse wave in the physiological tissue to be tested according to the first physiological signal and the second physiological signal. The physiological signals carried by the physiological tissues to be tested at two positions detected by the two transceiver circuits determine the propagation speed of the pulse wave in the physiological tissue, and the time difference of the physiological signals is more accurately determined, and the pulse is measured by two radio waves. The technical effect of the wave propagation speed in the physiological tissue is more accurate, and the technical problem of detecting the inaccurate result of the pulse wave propagation speed by the Doppler effect in the prior art is solved.

Claims

A pulse wave velocity detector includes:

a first signal generating circuit configured to emit a detection signal of a predetermined frequency;

a first signal detecting circuit configured to detect a first physiological signal carried by the detection signal of the predetermined frequency after passing through the physiological tissue to be tested at the first position;

a second signal detecting circuit configured to detect a second physiological signal carried by the detection signal of the predetermined frequency after passing through the physiological tissue to be tested at the second position, wherein the first signal generating circuit and the first signal detecting circuit Forming a first transceiver circuit, the first signal generating circuit and the second signal detecting circuit forming a second transceiver circuit;

And a processor configured to determine a propagation speed of the pulse wave in the physiological tissue to be tested according to the first physiological signal and the second physiological signal.
The probe according to claim 1, wherein

The first signal generating circuit includes:

a frequency f1 generator, configured to emit a detection signal having a frequency of f1;

a frequency f2 generator, configured to emit a detection signal having a frequency of f2;

a first combiner coupled to the frequency f1 generator and the frequency f2 generator, configured to combine the detection signal of the frequency f1 and the detection signal of the frequency f2 to obtain a first combination Road signal

a first transmit antenna, coupled to the first combiner, configured to transmit the first combiner signal, wherein the predetermined frequency of the probe signal comprises the first combiner signal.
The probe according to claim 2, wherein

The first signal detecting circuit includes:

The first receiving antenna is configured to receive the first signal to be tested, wherein the first signal to be tested carries the first physiological signal, and the first physiological signal is that the first combined signal passes the a physiological signal generated by the physiological tissue to be tested at the first position;

The first splitter is connected to the first receiving antenna, and is configured to divide the first signal to be tested into two paths according to a frequency, and obtain a first test signal with a frequency of f1 and a first test with a frequency of f2 Signal

a first frequency f1 detector connected to the first splitter, configured to detect a physiological signal carried in the first signal to be tested with the frequency f1;

a first frequency f2 detector connected to the first splitter and configured to detect a physiological signal carried in the first signal to be tested having the frequency f2,

The second signal detecting circuit includes:

The second receiving antenna is configured to receive the second signal to be tested, wherein the second signal to be tested carries the second physiological signal, and the second physiological signal is that the first combined signal passes the a physiological signal generated by the physiological tissue to be tested in the second position;

a second splitter, connected to the second receiving antenna, configured to divide the second signal to be tested into two paths according to a frequency, to obtain a second signal to be tested with a frequency of f1 and a second to be tested with a frequency of f2 signal;

a second frequency f1 detector connected to the second splitter, configured to detect a physiological signal carried in the second signal to be tested with the frequency f1;

The second frequency f2 detector is connected to the second splitter and configured to detect the physiological signal carried in the second signal to be tested of the frequency f2.
The probe according to claim 3, wherein

The processor is configured to calculate a propagation velocity of the pulse wave in the physiological tissue to be tested according to a formula PWV=d/deltaT, wherein deltaT=(deltaT1+deltaT2)/2, deltaT1 is the first frequency f1 The physiological signal carried in the first signal to be tested whose frequency is f1 detected by the detector and the delay of the physiological signal carried in the second signal to be measured detected by the second frequency f1 detector a difference, deltaT2 is a physiological signal carried in the first signal to be tested whose frequency is f2 detected by the first frequency f2 detector, and a frequency detected by the second frequency f2 detector is f2 a delay difference of the physiological signals carried in the two signals to be measured, deltaT is an average value of the delay differences, d is a distance between the first position and the second position, and PWV is the pulse wave in the The speed of propagation in the physiological tissue to be tested.
A pulse wave velocity detector includes:

a first signal generating circuit configured to emit a first detection signal of a predetermined frequency;

a first signal detecting circuit configured to detect a first physiological signal carried by the first detecting signal of the predetermined frequency after passing through the physiological tissue to be tested at the first position;

a second signal generating circuit configured to emit a second detecting signal of a predetermined frequency;

a second signal detecting circuit configured to detect a second physiological signal carried by the second detecting signal of the predetermined frequency after passing through the physiological tissue to be tested at the second position, wherein the first signal generating circuit and the first signal The detecting circuit constitutes a first transceiver circuit, and the second signal generating circuit and the second signal detecting circuit constitute a second transceiver circuit;

And a processor configured to determine a propagation speed of the pulse wave in the physiological tissue to be tested according to the first physiological signal and the second physiological signal.
The probe according to claim 5, wherein

The first signal generating circuit includes:

a frequency f11 generator, configured to emit a detection signal having a frequency of f11;

a frequency f21 generator, configured to emit a detection signal having a frequency of f21;

a first combiner coupled to the frequency f11 generator and the frequency f21 generator, configured to combine the detection signal of the frequency f11 and the detection signal of the frequency f21 to obtain a first combination a road signal, wherein the first detection signal of the predetermined frequency comprises the first combination signal;

a first transmitting antenna, connected to the first combiner, configured to transmit the first combined signal,

The first signal detecting circuit includes:

The first receiving antenna is configured to receive the first signal to be tested, wherein the first signal to be tested carries the first physiological signal, and the first physiological signal is that the first combined signal passes the a physiological signal generated by the physiological tissue to be tested at the first position;

The first splitter is connected to the first receiving antenna, and is configured to divide the first signal to be tested into two paths according to a frequency, and obtain a first test signal with a frequency of f11 and a first test with a frequency of f21. signal;

a frequency f11 detector connected to the first splitter and configured to detect a physiological signal carried in the first signal to be tested having the frequency f11;

The frequency f21 detector is connected to the first splitter and configured to detect a physiological signal carried in the first signal to be tested of the frequency f21.
The probe according to claim 6, wherein

The second signal generating circuit includes:

Frequency f12 generator, set to emit a detection signal with a frequency of f12;

a frequency f22 generator, configured to emit a detection signal having a frequency of f22;

a second combiner, connected to the frequency f12 generator and the frequency f22 generator, configured to combine the detection signal of the frequency f12 and the detection signal of the frequency f22 to obtain a second combination a road signal, wherein the second detection signal of the predetermined frequency comprises the second combination signal;

a second transmitting antenna, connected to the second combiner, configured to transmit the second combined signal,

The second signal detecting circuit includes:

a second receiving antenna, configured to receive a second signal to be tested, wherein the second signal to be tested carries the second physiological signal, and the second physiological signal is that the second combined signal passes a physiological signal generated by the physiological tissue to be tested in the second position;

a second splitter, connected to the second receiving antenna, configured to divide the second signal to be tested into two according to a frequency, to obtain a first signal to be tested having a frequency of f12 and a first to be tested having a frequency of f22 signal;

a frequency f12 detector connected to the second splitter and configured to detect a physiological signal carried in the second signal to be tested having the frequency f12;

The frequency f22 detector is connected to the second splitter and configured to detect a physiological signal carried in the second signal to be tested of the frequency f22.
The probe according to claim 7, wherein

The processor is configured to calculate a propagation velocity of the pulse wave in the physiological tissue to be tested according to a formula PWV=d/deltaT, wherein deltaT=(deltaT1+deltaT2)/2, deltaT1 is the frequency f11 detector The difference between the detected physiological signal carried in the first signal to be tested of f11 and the physiological signal carried in the second signal to be detected with the frequency f12 detected by the frequency f12 detector is deltaT2 The physiological signal carried in the first signal to be tested of the frequency f21 detected by the frequency f21 detector and the physiological signal carried in the second signal to be detected detected by the frequency f22 detector a delay difference of the signal, deltaT is an average value of the delay difference, d is a distance between the first position and the second position, and PWV is a propagation speed of the pulse wave in the physiological tissue to be tested .
A method for detecting pulse wave velocity, comprising:

Sending a detection signal of a predetermined frequency through the first signal generating circuit;

Detecting, by the first signal detecting circuit, the first physiological signal carried by the detection signal of the predetermined frequency after passing through the physiological tissue to be tested at the first position;

And detecting, by the second signal detecting circuit, the second physiological signal carried by the detection signal of the predetermined frequency after passing through the physiological tissue to be tested in the second position, wherein the first signal generating circuit and the first signal The detecting circuit constitutes a first transceiver circuit, and the first signal generating circuit and the second signal detecting circuit constitute a second transceiver circuit;

Determining a propagation speed of the pulse wave in the physiological tissue to be tested according to the first physiological signal and the second physiological signal.
A method for detecting pulse wave velocity, comprising:

Transmitting a first detection signal of a predetermined frequency by the first signal generating circuit;

Detecting, by the first signal detecting circuit, the first physiological signal carried by the first detecting signal of the predetermined frequency after passing through the physiological tissue to be tested at the first position;

Transmitting a second detection signal of a predetermined frequency by the second signal generating circuit;

Detecting, by the second signal detecting circuit, the second physiological signal carried by the second detecting signal of the predetermined frequency after passing through the physiological tissue to be tested at the second position, wherein the first signal generating circuit and the first signal detecting circuit Forming a first transceiver circuit, the second signal generating circuit and the second signal detecting circuit forming a second transceiver circuit;

Determining a propagation velocity of the pulse wave in the physiological tissue to be tested according to the first physiological signal and the second physiological signal.