WO2018117305A1

WO2018117305A1 - Device for manufacturing medical suture and method for manufacturing suture

Info

Publication number: WO2018117305A1
Application number: PCT/KR2016/015147
Authority: WO
Inventors: 장민서
Original assignee: (주)제이월드
Priority date: 2016-12-23
Filing date: 2016-12-23
Publication date: 2018-06-28

Abstract

The present invention relates to a device for manufacturing a suture used for surgery and a method for manufacturing a suture and, more specifically to a device for manufacturing a suture and a method for manufacturing a suture that does not require a suture knotting operation during a suturing operation, and according to the device for manufacturing a suture and the method for manufacturing a suture, of the present invention, physical properties such as good flexibility and excellent tensile strength and elongation can be obtained by having a crystallization lower than when using a preform having an orientation characteristic obtained through a method such as injection molding.

Description

Medical Suture Making Device and Suture Making Method

The present invention relates to a suture manufacturing apparatus and a suture manufacturing method used in surgical operations, and more particularly, to a suture manufacturing apparatus and a suture manufacturing method capable of producing a medical suture with excellent flexibility and excellent tensile strength and elongation. .

In the late 1960s, tissue sutures using barbed sutures, in which barbed sutures were cut out of the sutures to form barbs, were used to finish the sutures without tying the sutures. These barbed sutures form one or more barbed protrusions along the surface of the suture at regular intervals. When the sutures are inserted in one direction and pulled with tension in the opposite direction, the barbs placed on the surface of the suture are firmly adhered to the tissue. Unlike sutures that do not need to be knotted.

In the 1990s, Ruff in North Carolina and Sulamanidze in Russia used a new type of medical barbed sutures to improve facial, neck, and chest wrinkles or to pull facial tissue, in addition to surgical sutures. And plastic surgery for wrinkling. Since then, various medical threads for tissue fixation, including barbed sutures, have begun to serve two purposes: non-knot sutures and facelift.

Methods of making barbed sutures for surgical tissue suture and plastic surgery are described in US Patent 2004/0060410 Barbed suture and US 2003/0041426 A1 “Method for forming barbs in suture and apparatus for forming barbs. The method by cutting presented in the "methods of forming barbs on a suture and apparatus for performing same" is representative, and the majority of the commercially available products are manufactured by the present method.

However, in the case of the cutting method, since the surface of the suture yarn is shaved to form a barb, the size and thickness of the barb are limited, and the tip of the barb is too sharp to stimulate surrounding tissues and nerves. The strength of the suture yarn is significantly reduced compared to the same size sutures, and the relatively thin barbs produced by the cutting method are rapidly absorbed in the body, so that tissue loss is easily lost. have.

Meanwhile, Korean Patent No. 10-1057377 discloses a medical suture having a fine protrusion on a surface thereof and a method of manufacturing the same, and accordingly, when the medical suture is manufactured, the medical suture yarn itself is used as a raw material, and below the melting point in the outflow mold. The heat compression solid-state molding method which is manufactured under the temperature conditions and the constant pressure conditions more than transition temperature is taken.

However, in this method, the suture of the suture is heated by heating, and when the shrinkage occurs, the crystallinity increases, the elastic force decreases, and the suture loses the orientation because the suture is compressed under a constant pressure condition. Accordingly, since the tensile force is lowered as a whole and is generally compressed in the vertical direction of the alignment direction, the orientation of the molecules is dispersed during the compression and restoration process, and thus the suture is split.

In addition, US Pat. No. 8,216,497 discloses a method of manufacturing barbs by processing with a raw material in the form of a preform, but there is no mention of a method of manufacturing a preform, and no detailed description of the manufacturing process is given. As a result, the feasibility of the technology is ambiguous and it is currently not commercialized and commercially available.

In addition, US Patent US 2003/0149447 mentions that preforms can be manufactured by injection molding, but injection molding does not show flexibility because of no orientation of molecules, and is fragile and has a low tensile strength. have.

As described above, various methods have been used for the manufacture of medical seals having the function of tissue fixation, but there is a current demand for continuous development of technologies that can be used immediately and commercialized to compensate for the disadvantages of existing technologies. .

Accordingly, the present invention has been made to solve the problems presented above, an object of the present invention is to provide a medical suture manufacturing apparatus and suture manufacturing method having a barbed projection having orientation and flexibility.

1. a suture supply unit for supplying a suture to which a medical suture spool is mounted; A preheater for heating the suture to a predetermined temperature; A pressurizing roller unit for pressurizing the heated suture on the upper and lower surfaces; A die cut mold part which presses the pressurized suture on upper and lower surfaces to form cutting lines on both sides of the suture along a longitudinal direction; A twister unit twisting the suture continuously by applying rotational force to the suture; A suture winding unit for winding a suture having a barbed protrusion formed by the twister unit; A tensioner disposed at a front end of the preheating part and a rear end of the pressing roller part to impart a constant tension to the suture; And a cutting part disposed between the die cut mold part and the suture winding part to cut the suture such that the suture is wound to a predetermined length. The die cut mold part includes a cutting member at an upper mold and a lower mold. , The cutting line formed by the die cut molding unit is suture manufacturing apparatus, characterized in that continuously spaced apart at regular intervals in a state inclined at a predetermined angle toward one direction or both directions.

2. The suture manufacturing apparatus according to the above 1, wherein the suture supplied from the suture supply unit is continuously supplied to the preheating unit, the pressure roller unit, the die cut mold unit, the twister unit and the winding unit.

3. In the above 1, wherein the pressure roller unit, the first pressure roller, the second pressure roller and the third pressure roller is disposed sequentially, the second pressure roller is more suture than the first pressure roller Pressurizing, the third pressure roller is suture manufacturing apparatus, characterized in that for pressing the suture more than the second pressure roller.

4. In the above 1, wherein the die cut mold portion, by pressing the pressurized suture from the upper and lower surfaces to form a cutting line on both sides of the suture along the longitudinal direction at the same time spaced apart from the central axis of the suture along the longitudinal direction To form a cutting line for forming a plurality of through-holes that are continuously formed.

5. In the above 4, wherein the suture line on both sides of the suture and the through-hole of the suture central axis is formed to cross each other, suture manufacturing apparatus.

6. In the above 1, the suture manufacturing apparatus further comprises a through-hole forming portion for forming a plurality of through-holes continuously formed spaced apart at regular intervals on the suture's central axis.

7. In the above 6, wherein the through hole forming portion is located between the die cut mold portion and the twister portion, suture manufacturing apparatus.

8. according to the above 6, wherein the suture line of the suture both sides and the through-hole of the suture central axis is formed to cross each other, suture manufacturing apparatus.

9. In the above 1, the suture raw material is polydioxanone (polydioxanone), polylactic acid (poly- (l-lactic)), polyglycolic acid (poly-glycolic acid), polycaprolactone (polycaprolactone) and Suture manufacturing apparatus, characterized in that the bioabsorbable medical polymer material made of any one selected from these copolymers.

10. The suture manufacturing apparatus according to 1 above, wherein the suture raw material is a bio-non-absorbent medical polymer material made of any one selected from polypropylene (polyprophylene), nylon (nylon), and mixtures thereof.

11. A suture manufacturing method using a suture manufacturing apparatus according to any one of the above 1 to 10, comprising the steps of heating a medical suture raw material at a set temperature conditions; Pressing the heated suture through three steps to press molding; Pressing the press-molded suture on the upper and lower surfaces to form cutting lines on the upper and lower surfaces of the suture; And applying a tensile force and a rotational force to the suture in which the cutting line is formed to form a suture having a barbed protrusion. In the forming of the cutting line, the cutting line includes a suture along the longitudinal direction of the suture. Suture manufacturing method characterized in that the spaced apart at a predetermined interval in a state inclined at a predetermined angle toward one side or both directions on both sides continuously.

12. The method according to 11 above, wherein the set temperature is a temperature below the melting point of the suture raw material or above the glass transition temperature.

13. In the above 11, in the compression molding step, the pressure over the three steps, the first step and the second step is to press the suture more than the first step, the third step is to press the suture more than the second step Suture production method characterized in that.

14. The method of 11 above, further comprising a through-hole forming step of forming a plurality of cut lines for forming a plurality of through-holes continuously formed at regular intervals on the suture's central axis.

In the present invention, since the yarns having the determined orientation characteristics are used, the crystallinity is lower than that of the preform having the orientation characteristics obtained through the injection molding method, and thus the flexibility and excellent tensile strength and elongation can be obtained. Have.

In addition, by presenting a method of manufacturing a hollow product designed to maintain the orientation that is not mentioned in the existing technology in the molding process, it has the advantage that it can be manufactured in a variety of forms than barbed suture processed using conventional yarn. Can be.

1 is a configuration diagram schematically showing a suture manufacturing apparatus according to an embodiment of the present invention.

Figure 2 is a block diagram showing a pressure roller portion of the suture manufacturing apparatus according to the present invention.

Figure 3 is an exemplary view showing a process in which the pressure roller portion of the suture manufacturing apparatus according to the present invention sequentially compress the suture.

4 is a view showing a suture formed with cutting lines in accordance with the present invention.

5 is a flow chart showing a suture manufacturing method according to the present invention.

6 is a schematic view showing a suture manufacturing apparatus provided with a heating wire in the pressure roller unit according to another embodiment of the present invention.

7 is a configuration diagram schematically illustrating an example in which a cutting line for forming a through hole and a cutting line for forming a barb are alternately formed according to an embodiment of the present invention.

Hereinafter, the detailed description of the preferred embodiment of the present invention will be described with reference to the accompanying drawings. In the following description of the present invention, detailed descriptions of well-known functions or configurations will be omitted when it is deemed that they may unnecessarily obscure the subject matter of the present invention.

Embodiments in accordance with the concepts of the present invention may be variously modified and may have various forms, and specific embodiments will be illustrated in the drawings and described in detail herein. However, this is not intended to limit the embodiments in accordance with the concept of the present invention to a particular disclosed form, it should be understood to include all modifications, equivalents, and substitutes included in the spirit and scope of the present invention.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. Singular expressions include plural expressions unless the context clearly indicates otherwise.

Hereinafter, with reference to the accompanying drawings the present invention will be described in detail.

1 is a configuration diagram schematically showing a suture production apparatus according to an embodiment of the present invention, Figure 2 is a configuration diagram showing a pressure roller portion of the suture production apparatus according to the present invention, Figure 3 is a suture production apparatus according to the present invention Figure 4 is an exemplary view showing that the pressing roller portion of the suture is sequentially compressed, Figure 4 is a top view showing that the cutting line formed by the die cut mold portion of the suture manufacturing apparatus according to the present invention.

5 is a flowchart showing a suture manufacturing method of the present invention.

Referring to the drawings, the suture manufacturing apparatus 10 according to the present invention is a suture supply unit 100, preheating unit 200, pressure roller unit 300, die cut mold 400, twister portion 500 and suture It may be configured to include a winding portion 600, the cutting line formed by the die cut mold 400 is formed in a state inclined at a predetermined angle toward one direction or both directions, spaced at regular intervals and continuous Characterized in that formed.

The manufacturing method of the medical suture using the suture manufacturing apparatus will be described in detail for each step.

First, the medical suture raw material is heated at a melting point below the melting point or above the glass transition temperature (S101), for example, the suture raw material may be supplied through the suture supply unit 100 to be heated through the preheating unit 200.

More specifically, the suture supply unit 100 is a medical suture spool is mounted to supply the suture, the suture supplied from the suture supply unit 100, the preheating unit 200, the pressure roller unit 300, die cut mold The part 400, the twister 500, and the winding part 600 may be continuously supplied.

According to one embodiment of the present invention, the suture manufacturing apparatus presses the pressurized suture on the upper and lower surfaces to form cutting lines on both sides of the suture along the longitudinal direction, and at the same time spaced apart from the central axis of the suture along the longitudinal direction. And a die cut mold part which forms cutting lines for forming a plurality of through holes continuously formed.

According to another embodiment, the suture manufacturing apparatus may further include a through hole forming portion for forming a cutting line for forming a plurality of through holes continuously spaced apart at regular intervals on the suture's central axis. According to a more specific embodiment, the through hole forming portion may be located between the die cut mold portion and the twister portion.

According to an embodiment of the present invention, when the suture manufacturing apparatus forms a cutting line for forming a through hole as described above, the cutting line and the length for forming a through hole continuously spaced apart at regular intervals on the central axis of the suture along the longitudinal direction. Cutting lines formed on both sides of the suture along the direction may be formed to cross each other. Here, the staggered form means that the n-th cutting line formed on either side of the cutting lines formed on both sides of the suture is formed with a cutting line for forming a hole formed in the central axis of the suture, and the n + 1th cutting adjacent to the same side along the length direction It means to be located between the lines. An embodiment of staggered cutting line formation according to the present invention is shown in FIG. 7. In the case of forming the cut lines as described above, the maximum distance between the cut lines can be ensured to prevent the suture from being lowered despite the formation of the through holes.

If the distance between the hole and the edge of the suture is too close or the distance between any one and the adjacent hole is too close, the strength of the suture can be significantly reduced, so the distance between the edge of the hole and the suture and the adjacent one with the hole It is preferable to make the space | interval between a hole suitable. According to one embodiment, the spacing between the aperture and the edge of the suture may be between 50 μm and 1000 μm. For example, it may be 50 μm to 500 μm, 50 μm to 300 μm, 100 μm to 500 μm, 200 μm to 800 μm, and the like, and for example, 50 μm to 300 μm. The interval between any one of the holes and the adjacent holes may be 300 μm or more, preferably 500 μm or more.

The sutures formed with the through-holes manufactured using the manufacturing apparatus of the present invention have the effect of removing the wrinkles by lifting the skin by inducing the surrounding tissue cells of the sutures inserted into the skin to grow into the through-holes of the sutures to form new tissues in the skin. It has the effect of lasting semi-permanently. In addition, the suture produced by the manufacturing method of the present invention has the advantage that the strength of the suture is not significantly reduced, including a barb and through holes.

At this time, the suture raw material constituting the medical suture of the present invention is a bioabsorbable medical polymer, specifically, for example, polydioxanone, poly-l-lactic acid, polyglycolic acid Bio-absorbable medical sutures may be manufactured when a bio-absorbable medical polymer including any one selected from poly-glycolic acid, polycaprolactone, and copolymers thereof is used.

In addition, the suture raw material constituting the medical suture of the present invention is a bio-absorbable medical polymer, specifically, for example, polypropylene, nylon (nylon) and mixtures thereof may be selectively used. In the case of using the bioabsorbable medical polymer, the bioabsorbable medical suture may be manufactured.

On the other hand, the preheating unit 200 is for heating the supplied suture to a set temperature, it may be any one of two forms as will be described later.

The preheater 200 may be manufactured, for example, in the form of a cylinder, and a heating wire inside the wall of the preheater is installed to adjust the temperature of the preheater to a required temperature through a temperature controller. Can be.

In another form of the preheating unit, the

heating wires

311, 321, and 331 capable of heating inside the pressurizing roller unit 300 to be described below may be installed to adjust the temperature by the required temperature through a temperature controller. .

The temperature of the heat applied to the preheater 200 is equal to or lower than the glass transition temperature (Tg) of the suture raw material used to manufacture the suture whole body, and equal to or lower than the melting point (Tm), preferably 15 ° C. or lower (Tm-15). Melting point below 30 ° C (Tm-30 ° C).

Next, by pressing the suture heated by the step (S101) over three stages by compression molding (S102), which is shown in Figure 2, by pressing the rollers of three rows so that the suture can be gradually tapered The configured pressure roller 300 can be used.

The pressure roller 300 is for pressing the heated suture on the upper and lower surfaces, and in this case, a special process for protecting the orientation is required because the orientation is broken when the suture is used in a general roller compression method.

Therefore, the pressing roller unit 300, as shown in Figure 3, comprises a first pressing roller 310, the second pressing roller 320 and the third pressing roller 330 sequentially arranged, The second press roller 320 presses the suture more than the first press roller 310, and the third press roller 330 presses the suture more than the second press roller 320. It is preferable that the raw material is made to be gradually thinner.

At this time, the first pressure roller 310 is set to press the gap between the upper end and the lower end of the frame formed in the first pressure roller from 50% to 80% of the outer diameter of the raw material suture because it affects the orientation during excessive compression, The second press roller 320 pressurizes the raw material from the first press roller 310 again in the second press roller 320, and the gap between the upper end and the lower end of the mold formed on the roller at this time is also used in the first press roller. It is desirable to set the pressure to 50% to 80% of the outer diameter of the raw material suture.

Finally, the interval between the upper end and the lower end of the frame formed in the third pressure roller 330 is also set to press the level of 50% to 80% of the outer diameter of the pressurized suture from the second pressure roller 320. In this setting, the suture processed through the pressing roller portion can finally obtain a thickness of about 1/2 the initial yarn thickness, and can be three times the width of the initial yarn thickness.

The pressure roller unit 300 is provided with two or more pressure roller units installed in parallel so as to be able to independently rotate each other, and more preferably three, and adjust the interval of the pressure roller so as to control the thickness of the hollow product up to a micro unit. A regulator may be included.

It is preferable that all pressurized rollers include a heating wire, thereby allowing the temperature to be transmitted to the raw material. Heat is imparted to the polymer to reduce the crystallinity of the polymer to create a good processability environment, but because it affects the orientation is to be carried out under conditions that do not affect the physical properties.

Next, to form a cutting line continuously formed spaced apart at regular intervals on the upper and lower surfaces of the compressed suture raw material (S103), it can be performed using the die cut mold 400.

Die cut mold 400 is to form a cutting line on both sides of the suture along the longitudinal direction by pressing the pressurized suture, as shown in Figure 4, the plate through the pressure roller 300 A cutting line for forming barbs is formed on the sutures compressed in the form.

The cutting line may be formed using a knife, laser, press molding injection molding, stamping, or the like.

Although not specifically illustrated, the injection molding by press molding is configured to form a cutting line after press working on a plate-shaped suture that is pressed into a plate shape, and the upper mold or the lower mold is fixed to one end and the other end of the suture. Cutting members such as blades can be configured to form a cutting line continuously in an inclined angle.

Therefore, when the press working by the cutting member of the upper mold and the lower mold, the cutting line inclined at a constant angle on both sides in the longitudinal direction of the suture is continuously formed.

At this time, the cutting lines formed on both sides may be formed in the same shape, as shown in (a) of FIG. 4, or in both directions as shown in (b) of FIG. 4.

Next, by applying a tensile force and a rotational force to the suture formed cut line forming a suture formed barbs projection (S104), which forms a barbed projection through the twister portion 500, the winding portion 600 ) Can be wound up.

The twister 500 is to twist the suture continuously by applying a rotational force to the suture, and in this step, one side of the suture formed with the cutting line is fixed and the other side is continuously rotated so that the entire raw material is twisted in a spiral form. This results in the formation of twisted yarns in the form of bands of twisted raw material, ie projections.

Accordingly, a rotation of 90 ° per cm length of the suture is added to form a spiral protrusion, and when inserted into the soft tissue, it has an anchoring ability in the opposite direction of insertion.

In this case, the spiral protrusion may be formed in one direction or in both directions, as shown in (a) and (b) of FIG.

Accordingly, the suture formed with the barbed protrusion is wound up through the suture winding unit 600.

On the other hand, it is preferable to further include a cutting portion 700 disposed between the die cut mold portion 400 and the suture winding portion 600, the cut portion 700 is the suture so that the suture is wound to a predetermined length To cut.

In addition, it is preferable to impart a constant tension to the suture that is provided with the tensioner 800 is disposed at the front end of the preheating portion and the rear end of the pressure roller portion.

6 is a schematic view showing a suture manufacturing apparatus according to another embodiment of the present invention.

As shown in the figure, the suture manufacturing apparatus 20 according to the present invention is a suture feeder 100, a pressing roller 300 (300 ') having a heating wire (311`, 321`, 331`), die cut mold ( 400, the twister 500 and the suture winding 600 may be configured, wherein the cutting line formed by the die cut mold 400 is inclined at a predetermined angle toward one direction or both directions It is formed as, characterized in that formed to be continuously spaced apart a predetermined interval.

The suture manufacturing apparatus 20 according to another embodiment of the present invention includes the same configuration as the suture manufacturing apparatus 10 with reference to FIGS. 1 to 5, and a detailed description thereof will be omitted.

The suture manufacturing apparatus 10 includes a preheating unit 200 for heating the suture, while the suture manufacturing apparatus 20 does not include a separate preheating unit.

The pressure roller part 300` constituting the suture manufacturing apparatus 20 includes a first pressure roller 310 ', a second pressure roller 320', and a third pressure roller 330 ', and each pressure roller ( 310 ′, 320 ′, and 330 ′ may be provided with

heating wires

311, 321, and 331 that apply heat to the suture.

Therefore, the pressurizing roller unit 300 ′ provided with the

heating wires

311, 321, and 331 has a feature that can simultaneously heat the suture while pressing.

Since the suture manufactured through the suture manufacturing method uses a yarn whose orientation characteristics are determined, the crystallinity is low and the tensile strength and elongation are lower than that of a preform having an orientation characteristic obtained through injection molding or the like. It has the advantage of obtaining excellent physical properties.

[Description of the code]

10, 20: suture feeder

100: suture supply unit

200: preheating unit

300, 300`: Pressing roller part

311, 321, 331, 311`, 321`, 331`: heating wire

310, 310`: first press roller

320, 320`: 2nd pressure roller

330, 330`: 3rd pressure roller

400: die cut mold part

500: twister

600: suture winding

700: cutout

800: tensioner

Claims

A suture supply unit mounted with a medical suture spool to supply a suture;

A preheater for heating the suture to a predetermined temperature;

A pressurizing roller unit for pressurizing the heated suture on the upper and lower surfaces;

A die cut mold part which presses the pressurized suture on upper and lower surfaces to form cutting lines on both sides of the suture along a longitudinal direction;

A twister unit twisting the suture continuously by applying rotational force to the suture;

A suture winding unit for winding a suture having a barbed protrusion formed by the twister unit;

A tensioner disposed at a front end of the preheating part and a rear end of the pressing roller part to impart a constant tension to the suture; And

And a cutting part disposed between the die cut mold part and the suture winding part to cut the suture such that the suture is wound to a predetermined length.

The die cut mold part is provided with a cutting member in the upper mold and the lower mold,

The cutting line formed by the die cut molding unit is suture manufacturing apparatus, characterized in that continuously spaced apart at regular intervals inclined at a predetermined angle toward one direction or both directions.
The method of claim 1,

The suture yarn supplied from the suture supply unit is a suture manufacturing apparatus characterized in that the continuous supply to the preheating unit, pressure roller portion, die cut mold portion, twister portion and the winding portion.
The method of claim 1,

The pressure roller unit,

A first pressure roller, a second pressure roller, and a third pressure roller which are sequentially disposed;

The second pressure roller presses the suture more than the first pressure roller, the third pressure roller suture manufacturing apparatus, characterized in that to press the suture more than the second pressure roller.
The method of claim 1,

The die cut mold portion,

Pressing the pressurized suture on the upper and lower surfaces to form cutting lines on both sides of the suture along the longitudinal direction, and at the same time, cutting lines for forming a plurality of through-holes which are continuously spaced apart from the center axis of the suture along the longitudinal direction. Forming a,

Suture manufacturing device.
The method of claim 4, wherein the cut lines on both sides of the suture and the through-holes of the suture central axis are formed alternately with each other,

Suture manufacturing device.
The method of claim 1,

Further comprising a through hole forming portion for forming a plurality of cut lines for continuously forming a plurality of through holes spaced apart at regular intervals on the suture's central axis,

Suture manufacturing device.
The method of claim 6,

The through hole forming portion is located between the die cut mold portion and the twister portion,

Suture manufacturing device.
The method of claim 6,

Cut lines on both sides of the suture and the through-hole of the suture central axis is formed to cross each other,

Suture manufacturing device.
The method of claim 1,

The suture raw material is selected from polydioxanone, poly- (l-lactic acid), polyglycolic acid, polycaprolactone, and copolymers thereof Suture manufacturing apparatus, characterized in that the bioabsorbable medical polymer material consisting of one.
The method of claim 1,

The suture raw material is a suture manufacturing apparatus, characterized in that the non-absorbent medical polymer material made of any one selected from polypropylene (polyprophylene), nylon (nylon) and mixtures thereof.
In the suture manufacturing method using a suture production apparatus according to any one of claims 1 to 10,

Heating the medical suture raw material at a set temperature condition;

Pressing the heated suture through three steps to press molding;

Pressing the press-molded suture on the upper and lower surfaces to form cutting lines on the upper and lower surfaces of the suture;

And applying a tensile force and a rotational force to the suture in which the cutting lines are formed to form a suture having a barbed protrusion.

In the step of forming the cutting line,

The cutting line is a suture manufacturing method characterized in that it is continuously spaced at regular intervals in a state inclined at a predetermined angle toward one side or both directions on both sides of the suture along the longitudinal direction of the suture.
The method of claim 11,

The set temperature is a suture manufacturing method, characterized in that the temperature below the melting point of the suture raw material or more than the glass transition temperature.
The method of claim 11,

In the compression molding step,

Pressing over the three stages,

Step 2 pressurizes the suture more than step 1, and step 3 presses the suture more than step 2.
The method of claim 11,

Further comprising a through-hole forming step of forming a cutting line for forming a plurality of through-holes continuously formed at a predetermined interval spaced apart from the central axis of the suture,

Suture manufacturing method.