WO2018110728A1

WO2018110728A1 - Mixture solvent spray generation device for inhalation toxicity test

Info

Publication number: WO2018110728A1
Application number: PCT/KR2016/014616
Authority: WO
Inventors: 전기수; 이진규; 송경석; 백동석; 성재혁; 최병길; 류현열; 이재성; 김희중; 조광현; 최정석
Original assignee: 주식회사 에이치시티엠; (재)한국건설생활환경시험연구원
Priority date: 2016-12-12
Filing date: 2016-12-13
Publication date: 2018-06-21
Also published as: KR101878893B1; KR20180067763A

Abstract

The present invention relates to a mixture solvent spray generation device for an inhalation toxicity test, and provides a mixture solvent spray generation device for an inhalation toxicity test, the device enabling: an inhalation toxicity test to be more accurately performed since a mixture solvent containing a mixture of two or more liquid solvents is supplied to a high-temperature heating plate such that all of the two or more liquid solvents are simultaneously vaporized and form a spray, thereby enabling the spray containing all of the two or more liquid solvents to be generated; the mixture solvent spray to be continuously and stably generated since the mixture solvent is supplied onto the surface of the heating plate and, simultaneously, vaporized rapidly so as to generate the spray; and spray generation performance to further improve since a storage groove is formed at the heating plate and the liquid mixture solvent is supplied to the storage groove, thereby enabling slipping and dripping, caused by the Leidenfrost effect, of the liquid mixture solvent on the heating plate to be prevented.

Description

Mixed solvent spray generator for inhalation toxicity test

The present invention relates to a mixed solvent spray generating device for inhalation toxicity test. More specifically, by supplying a mixed solvent in which two or more liquid solvents are mixed to a high temperature heating plate, two or more liquid solvents are all vaporized and sprayed at the same time, thereby spraying all of the two or more liquid solvent components. Inhalation toxicity test can be performed more accurately, and the mixed solvent is supplied to the heating plate surface, and at the same time, the spray is generated by vaporization in a short time, so that the mixed solvent spray can be continuously and stably generated. By forming a storage groove in the plate and supplying the liquid mixed solvent to the storage groove, the liquid mixed solvent can be prevented from slipping down by the Leidenfrost effect on the heating plate, thereby improving spray generation performance. Mixed solvent spray for inhalation toxicity testing that can be further improved It relates to the raw device.

In general, various types of organic solvents are used in industrial sites. When the organic solvent evaporates in an enclosed space where there is little air movement around the place, organic solvent poisoning occurs by entering the body through the worker's respiratory system and skin.

When such an organic solvent is introduced into the body, anesthesia appears at high concentrations, and at low concentrations, anxiety symptoms such as anxiety and headache appear.

In addition, since each solvent has its own toxicity, strong organic solvents, when absorbed by the human body through the skin or respiratory tract, cause organic solvent poisoning that causes disorders in nerves, respiratory organs, digestive organs and various organs. At the manufacturing and handling sites, the installation of various safety facilities such as fans and the wearing of protective equipment are mandatory.

However, in actual industrial sites, such safety obligations are often not kept due to inconvenience, leading to a great casualty.

Inhalation toxicity studies on such organic solvents are generally conducted in a manner of evaluating the hazards by exposing a test substance to a test animal at a constant concentration and duration, and its importance is increasing recently.

Inhalation toxicity studies on organic solvents can be used to assess the hazards of skin absorption or respiration, to produce a Lithal Concentration of 50 Percent Kill (LC50) as an indicator of toxicity, and to establish exposure criteria to ensure the safety of the working environment. Basic data, experimental reproduction of respiratory diseases and various diseases, carcinogenicity studies of malignant tumors, in vivo behavior of inhaled substances, toxicity prediction and human disease model studies, respiratory organs, especially lung structure and function studies. It is largely classified, and it is also very important as an area of industrial toxicity research for predicting health disorders and identifying disease causes by handling chemicals in the working environment.

Recently, as the spread of electronic cigarettes in addition to the organic solvents in the industrial field has been widely spread, if the liquid fuel used for electronic cigarettes is inhaled through the respirator while being vaporized and sprayed, there is no concern about the safety of the human body. It is increasing very much. Therefore, the inhalation toxicity test for the electronic cigarette spray is also a very important research field at the national level.

In general, the liquid solvent gas inhalation toxicity test apparatus is composed of a gas generator for vaporizing the liquid solvent to generate a spray, and an exposure chamber for supplying the organic solvent gas generated from the gas generator to the experimental animal, wherein the gas generator The gas is configured to generate a gas by heating and vaporizing the liquid solvent.

The liquid fuel used in the electronic cigarette is generally used by mixing two or more liquid solvents. For example, propylene glycol (Propylene Glycol) and vegetable glycerine (vegetable Glycerin) is essentially included in various ratios, in addition to the liquid solvents for other various flavors are mixed.

In the case of e-cigarettes, the spray is generated in such a way that instantaneous high temperature is generated through the atomizer so that a mixed solvent mixed with various liquid solvents is vaporized sprayed instantaneously. It must be very large and of course it must be possible to produce a continuous spray.

In the case of a general liquid solvent gas inhalation toxicity test apparatus according to the prior art, the gas is generated by heating and vaporizing a large amount of the liquid solvent.In the case of a mixed solvent in which two or more liquid solvents are mixed, the boiling point temperature of the liquid solvent Since different components are sprayed differently at different heating times, there is a problem in that accurate inhalation toxicity test is not performed because the components are different from the spray generated in an electronic cigarette.

In addition, in the conventional liquid solvent gas inhalation toxicity test apparatus according to the prior art, if you want to perform a test for a mixed solvent of two or more liquid solvents, mixing the spray generated by separately heating each of the single liquid solvent in a separate space In this case, the mixed spray is generated, but in this case, since the individual gas generators have to be provided as much as the type of the liquid solvent, there is a problem that the apparatus becomes large and complicated, and the manufacturing and maintenance costs also increase.

The present invention has been invented to solve the problems of the prior art, an object of the present invention by supplying a mixed solvent of two or more liquid solvents to a high temperature heating plate, at least two liquid solvents are all vaporized at the same time spray Can generate a spray containing both of the two or more liquid solvent components, allowing for more accurate inhalation toxicity testing, while the mixed solvent is supplied to the heating plate surface and vaporized in a short time It is to provide a mixed solvent spray generating apparatus that can generate a mixed solvent spray continuously and stably.

Another object of the present invention is to form a storage groove in the heating plate and supply the liquid mixed solvent to the storage groove, it is possible to prevent the liquid mixed solvent from slipping down by the Leidenfrost effect on the heating plate and It is to provide a mixed solvent spray generating apparatus that can further improve the spray generating performance through this.

Another object of the present invention is to heat the clean air supplied to the space inside the main case through the air heating unit, it is possible to prevent the condensation of the spray that may occur in the space inside the main case, thereby further improving the spray generation performance It is to provide a mixed solvent spray generating device that can be made.

The present invention provides a mixed solvent spray generating apparatus for generating a spray by vaporizing a mixed solvent of two or more liquid solvents, comprising: a main case having an accommodation space formed therein; A heating plate disposed inside the main case and configured to generate heat by receiving power from a separate power supply device; A mixed solvent supply unit configured to quantitatively supply the mixed solvent to fall on the surface of the heating plate; An air supply unit supplying clean air to an inner space of the main case; And a control unit which controls the mixed solvent supply unit and the air supply unit and controls the temperature of the heating plate, wherein the control unit has the highest boiling point among boiling point temperatures of two or more liquid solvents mixed in the mixed solvent. It provides a mixed solvent spray generating apparatus, characterized in that the operation is controlled to be supplied to the surface of the heating plate in a state where the temperature of the heating plate is higher than or equal to the temperature.

In this case, a storage groove may be formed on the surface of the heating plate so that the mixed solvent may be dropped and temporarily stored.

In addition, a mixed solvent inlet port is formed at one side of the main case to allow the mixed solvent to be introduced, an air inlet port is formed to allow the clean air to be introduced, and the other side of the main case is sprayed in an internal space. A spray discharge port can be formed so that it can be discharged.

In addition, a flow guide part may be formed at an inner end of the mixed solvent inlet port to guide the flow path of the mixed solvent so that the mixed solvent introduced into the storage groove of the heating plate may fall.

The air supply unit may further include a clean air supply for generating and supplying clean air, an air pipe connecting the clean air supply and the air inflow port, and air mounted on the air pipe to adjust a flow rate of the clean air. It includes a flow controller, the control unit may control the air flow controller to adjust the discharge concentration of the spray discharged to the discharge port of the main case.

The mixed solvent spray generator may further include an air heating unit capable of heating the clean air supplied to the main case.

In this case, the air heating unit includes a plurality of heating baffles disposed adjacent to the air inlet port in the main case inner space so that clean air flowing into the main case inner space through the air inlet port passes through and exchanges heat. The heating baffle may be in contact with the heating plate to be thermally conductive from the heating plate.

According to the present invention, by supplying a mixed solvent in which two or more liquid solvents are mixed to a high temperature heating plate, two or more liquid solvents are all vaporized and sprayed at the same time, thereby containing all two or more liquid solvent components. It is possible to generate a spray, so that the inhalation toxicity test can be performed more accurately, and the mixed solvent is supplied to the heating plate surface, and at the same time, the spray is generated by vaporization in a short time, so that the mixed solvent spray can be continuously and stably generated. There is.

In addition, by forming a storage groove in the heating plate and supplying a liquid mixed solvent to the storage groove, it is possible to prevent the liquid mixed solvent from slipping down by the Leidenfrost effect on the heating plate, thereby spraying There is an effect that can further improve the generation performance.

In addition, by heating the clean air supplied to the space inside the main case through the air heating unit, it is possible to prevent the condensation of the spray that may occur in the space inside the main case, thereby improving the spray generation performance have.

1 is a conceptual diagram schematically showing the configuration of a mixed solvent spray generating apparatus according to an embodiment of the present invention,

2 is a functional block diagram schematically showing a configuration of a mixed solvent spray generating apparatus according to a function according to an embodiment of the present invention;

3 is an enlarged view of portion "A" of FIG. 1 to explain another structure of the mixed solvent spray generating apparatus according to an embodiment of the present invention.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. First of all, in adding reference numerals to the components of each drawing, it should be noted that the same reference numerals are used as much as possible even if displayed on different drawings. In addition, in describing the present invention, when it is determined that the detailed description of the related well-known configuration or function may obscure the gist of the present invention, the detailed description thereof will be omitted.

1 is a conceptual diagram schematically showing the configuration of the mixed solvent spray generating apparatus according to an embodiment of the present invention, Figure 2 is a schematic view of the configuration of the mixed solvent spray generating apparatus according to an embodiment of the present invention The functional block diagram shown.

The mixed solvent spray generating device according to an embodiment of the present invention is a device for generating a spray (P) by vaporizing a mixed solvent of two or more liquid solvents, such as the liquid fuel of the electronic cigarette, the main case 100 and And a heating plate 200, a mixed solvent supply unit 300, an air supply unit 400, and a control unit 500.

Such a mixed solvent spray generating apparatus may be utilized as a spray generator for the inhalation toxicity test for the mixed solvent. That is, the exposure chamber 600 is connected to the mixed solvent spray generating apparatus according to the embodiment of the present invention, and the spray P generated from the mixed solvent spray generating apparatus is exposed to the exposure chamber 600. It may be supplied to allow inhalation toxicity testing to be performed through experimental animals.

The main case 100 may be formed in the form of a hollow cylindrical pipe in which an accommodating space is formed, and both ends of the main case 100 are hermetically coupled to each other so that the closing cover 101 is sealed to block the internal space.

In the finishing cover 101 coupled to one side of the main case 100, a mixed solvent inlet port 110 is formed to allow the mixed solvent to flow into the inner space of the main case 100, and clean air may be introduced. The air inlet port 120 is formed to be. A spray discharge port 130 is formed in the finishing cover 101 coupled to the other side of the main case 100 so that the spray P generated in the inner space of the main case 100 can be discharged.

The heating plate 200 is disposed inside the main case 100 and is configured to generate heat by receiving power from a separate power supply device 210. The heating plate 200 has a heating coil 201 embedded therein, the heating coil 201 is generated by receiving power from the power supply device 210, the heating plate 200 is the heating coil 201 Heat from the heat conduction is configured to generate heat.

The mixed solvent supply unit 300 quantitatively supplies the mixed solvent to fall on the heating plate 200 surface, and a metering pump 310 for quantitatively supplying the mixed solvent in which two or more liquid solvents are mixed in a liquid state, and a metering pump Including a solvent supply pipe 320 connecting the mixed solvent inlet port 110 of the main case 100 from the metering pump 310 so that the mixed solvent supplied from the 310 flows into the inner space of the main case 100 Can be configured.

The air supply unit 400 is configured to supply clean air to the internal space of the main case 100, and includes a clean air supply 410 for generating and supplying clean air, a clean air supply 410, and a main case 100. It may be configured to include an air pipe 430 for connecting the air inlet port 120, and an air flow controller 420 mounted on the air pipe 430 to adjust the supply flow rate of the clean air.

The controller 500 controls the operations of the mixed solvent supply unit 300 and the air supply unit 400, and controls the temperature of the heating plate 200.

That is, the metering pump 410 of the mixed solvent supply unit 300 is controlled by the control unit 500 to adjust the supply amount of the mixed solvent, the air flow controller 420 of the air supply unit 400 is the control unit ( The operation control by 500 may adjust the supply amount of clean air. At this time, by adjusting the supply amount of the clean air through the air flow controller 420, it is possible to adjust the discharge concentration of the spray (P) discharged to the discharge port 130 of the main case 100.

According to this configuration, the mixed solvent is quantitatively supplied to the heating plate 200 at a fine flow rate from the mixed solvent supply unit 300, and is vaporized as it is heated by the heating plate 200 to generate the spray P. At the same time, clean air is supplied from the air supply unit 400, and the spray P of the mixed solvent and the clean air are mixed and discharged through the discharge port 130 in a diluted state to an appropriate concentration. The mixed solvent spray P discharged through the discharge port 130 is supplied to the exposure chamber 600 through the connection pipe, and exposed to the experimental animal in the exposure chamber 600 to perform the inhalation toxicity test.

At this time, the concentration detection unit 610 for detecting the concentration of the mixed solvent spray (P) supplied to the exposure chamber 600 is provided, the concentration detection unit 610 is exposed to the discharge port 130 of the main case 100 It may be connected and mounted on the connection pipe connecting the chamber 600, a gas chromatography-type detection device may be utilized.

The controller 500 may control the air flow controller 420 to change the concentration of the mixed solvent spray P according to the concentration value of the mixed solvent spray P detected by the concentration detector 610.

On the other hand, the control unit 500 according to an embodiment of the present invention is mixed in a state where the temperature of the heating plate 200 is higher than or equal to the highest boiling point temperature of the boiling point temperature for two or more liquid solvents mixed in the mixed solvent The solvent is controlled to supply the surface of the heating plate 200.

For example, when two liquid solvents are mixed with a mixed solvent, and the boiling point temperatures of these liquid solvents are 300 ° C. and 400 ° C., respectively, they are higher than the highest boiling point temperature of 400 ° C. (for example, 410 ° C.) and the mixed solvent is heated by the mixed solvent supply unit 300 while maintaining the temperature of the heating plate 200 at the same temperature (400 ° C.) and thus maintaining the temperature of the heating plate 200 at a high temperature. The operation is controlled to be supplied to the surface of the plate 200.

As such, when the temperature of the heating plate 200 is higher than or equal to the boiling point temperature of two or more liquid solvents mixed in the mixed solvent and the mixed solvent is supplied to the heating plate 200, the two mixed in the mixed solvent All of the above liquid solvents vaporize at the same time and evaporate.

Therefore, since the spray P generated by the vaporization of the mixed solvent contains not only one component of two or more liquid solvents but also all two or more liquid solvent components, the spraying component of the actual mixed solvent It is possible to generate a spray having the same component as.

In this way, by generating a spray of the same component as the actual mixed solvent spray component, it is supplied to the exposure chamber 600 to perform the inhalation toxicity test, it is possible to obtain accurate test results.

In particular, when the mixed solvent is quantitatively supplied at a minute flow rate using the metering pump 310 of the mixed solvent supply unit 300, the mixed solvent is supplied to the heating plate 200 surface and vaporized in a short time to generate spray. Therefore, the mixed solvent spray can be generated continuously and stably.

In addition, a storage groove 202 is formed on the surface of the heating plate 200 according to an embodiment of the present invention so that the mixed solvent may be temporarily stored by dropping as shown in the enlarged view of FIG. 3. Spray generation performance to a solvent can be improved.

That is, while the liquid mixed solvent supplied from the mixed solvent supply unit 300 is supplied at a normal temperature state, the heating plate 200 is maintained at a relatively high temperature higher than the boiling point temperature of the mixed solvent, and thus, the liquid mixed solvent of the normal temperature state When is supplied to the surface of the heating plate 200, the liquid mixed solvent may slide down from the surface of the heating plate 200 by the Leidenfrost effect. In order to prevent the liquid mixed solvent from flowing down, a storage groove 202 may be formed on the heating plate 200 surface, and the liquid mixed solvent supplied from the mixed solvent supply unit 300 is supplied to the storage groove 202. By making it possible, the spray generation performance with respect to the liquid mixed solvent can be improved.

In addition, when the storage groove 202 is formed on the heating plate 200 surface as described above, it is preferable that the mixed solvent supplied from the mixed solvent supply unit 300 is guided to fall into the storage groove 202. At the inner end of the mixed solvent inlet port 110 of the case 100, the flow guide part 111 for guiding the flow path of the mixed solvent so that the introduced mixed solvent may fall into the storage groove 202 of the heating plate 200. Is preferably formed. The flow guide 111 may be formed in the shape of a curved tube or a pipe, and may be formed to extend from the mixed solvent inlet port 110 to an upper adjacent portion of the storage groove 202.

Mixed solvent spray generating apparatus according to an embodiment of the present invention may further include an air heating unit 700 that can heat the clean air supplied to the main case (100).

As described above, the liquid mixture solvent at room temperature is supplied to the surface of the hot heating plate 200 and heated on the heating plate 200 to generate spray, so that the temperature of the spray is relatively high. Is formed.

At this time, as the clean air also flows into the room temperature state, condensation of spray may occur in the inner space of the main case 100. Therefore, in one embodiment of the present invention by heating the clean air supplied to the inside of the main case 100 through the air heating unit 700 to supply a relatively high temperature clean air, spraying in the inner space of the main case 100 Condensation can be prevented. When the condensation of the spray is prevented in this way, the spray amount can be prevented from being reduced and the spray performance can be further improved.

The air heating unit 700 may be formed separately in the form of heating the air pipe 430 outside the main case 100, the air heating unit 700 according to an embodiment of the present invention is a heating plate ( 200 is formed using the heat generated from.

For example, the air heating unit 700 has an air inlet port 120 in the inner space of the main case 100 so that clean air flowing into the inner space of the main case 100 passes through the air inlet port 120 and exchanges heat. And a plurality of heating baffles 710 disposed adjacent to each other. In this case, the plurality of heating baffles 710 may be coupled to the heating plate 200 to be thermally conductive from the heating plate 200. have.

The heating baffle 710 may be arranged such that clean air flowing from the air inlet port 120 flows in a zigzag manner, as shown in FIG. It may be arranged to cross the lower portion, the left end and the right end, etc. so that the clean air may flow in a zigzag manner through the flow hole 711. At this time, since the heating baffle 710 is in contact with the heating plate 200, the heat is conducted from the heating plate 200 to maintain a high temperature state, the clean air is heated by heat exchange in the process of passing clean air.

As the clean air is heated through the air heating unit 700 as described above, condensation of the spray is prevented in the inner space of the main case 100, and thus spray generation performance can be further improved.

The above description is merely illustrative of the technical idea of the present invention, and those skilled in the art to which the present invention pertains may make various modifications and changes without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are not intended to limit the technical idea of the present invention but to describe the present invention, and the scope of the technical idea of the present invention is not limited by these embodiments. The protection scope of the present invention should be interpreted by the following claims, and all technical ideas within the equivalent scope should be interpreted as being included in the scope of the present invention.

Claims

In the mixed-solvent spray generating apparatus which vaporizes the mixed solvent which mixed two or more liquid solvents, and produces a spray,

A main case having an accommodation space formed therein;

A heating plate disposed inside the main case and configured to generate heat by receiving power from a separate power supply device;

A mixed solvent supply unit configured to quantitatively supply the mixed solvent to fall on the surface of the heating plate;

An air supply unit supplying clean air to an inner space of the main case; And

Control unit for operation control of the mixed solvent supply unit and air supply unit and operation control of the temperature of the heating plate

The control unit may include the mixed solvent on the surface of the heating plate in a state where the temperature of the heating plate is higher than or equal to the highest boiling point temperature of two or more liquid solvents mixed in the mixed solvent. A mixed solvent spray generator, characterized in that the operation control to be supplied.
The method of claim 1,

Mixed solvent spray generating device, characterized in that the storage groove is formed on the surface of the heating plate so that the mixed solvent is temporarily stored.
The method of claim 2,

One side of the main case is a mixed solvent inlet port is formed to allow the mixed solvent to be introduced, an air inlet port is formed to allow the clean air to be introduced, the other side of the main case is sprayed from the internal space is discharged Mixed solvent spray generating device, characterized in that the spray discharge port is formed to be.
The method of claim 3, wherein

And a flow guide portion configured to guide a flow path of the mixed solvent so that the introduced mixed solvent may fall into the storage groove of the heating plate at an inner end of the mixed solvent inflow port.
The method of claim 3, wherein

The air supply unit

A clean air supplier for generating and supplying clean air, an air pipe connecting the clean air supply and the air inlet port, and an air flow controller mounted on the air pipe to adjust a flow rate of clean air,

The control unit is a mixed solvent spray generating device, characterized in that for controlling the discharge concentration of the spray discharged to the discharge port of the main case by controlling the air flow regulator.
The method of claim 3, wherein

Mixed solvent spray generating device further comprises an air heating unit capable of heating the clean air supplied to the main case.
The method of claim 6,

The air heating unit

And a plurality of heating baffles disposed adjacent to the air inlet port in the main case inner space so that clean air flowing into the main case inner space through the air inlet port passes through and exchanges heat.

The heating baffle is a mixed solvent spray generating device, characterized in that in contact with the heating plate to be thermally conductive from the heating plate.