WO2018106202A1 - Système de distribution d'agent d'embolisation à extrémité de barrière - Google Patents

Système de distribution d'agent d'embolisation à extrémité de barrière Download PDF

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Publication number
WO2018106202A1
WO2018106202A1 PCT/TR2017/050194 TR2017050194W WO2018106202A1 WO 2018106202 A1 WO2018106202 A1 WO 2018106202A1 TR 2017050194 W TR2017050194 W TR 2017050194W WO 2018106202 A1 WO2018106202 A1 WO 2018106202A1
Authority
WO
WIPO (PCT)
Prior art keywords
embolization agent
catheter
barrier
delivery
embolization
Prior art date
Application number
PCT/TR2017/050194
Other languages
English (en)
Inventor
Faik HASAR
Meral HASAR
Original Assignee
Mega-Med Saglik Gida Teks. Ith. Ihr. Tic. Ve San. Ltd. Sti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mega-Med Saglik Gida Teks. Ith. Ihr. Tic. Ve San. Ltd. Sti filed Critical Mega-Med Saglik Gida Teks. Ith. Ihr. Tic. Ve San. Ltd. Sti
Publication of WO2018106202A1 publication Critical patent/WO2018106202A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00778—Operations on blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic

Definitions

  • the invention is a delivery system that will provide the full interpenetration of the active embolization agent to the vessel wall in the treatment and prevention of any invasive and surgical vascular disease and clinical outbreaks caused by vascular enlargement and deformation.
  • the aim of the invention is; delivery of the embolization agent directly only to the vessel wall which is desired to be treated rather than to the proximal side of the vessel, to prevent it from moving to healthy vessel or to main vessel, and to provide a more effective solution for closing the veins of vessel side branches.
  • the embolization agent is sent from the open end of the delivering catheter to the end of the vein to be treated, that is, to the point where it joins with the main artery, there is no convergence in the desired position, which can reduce the success rate of the operation.
  • the embolization agent is delivered not from the catheter end, but from the hole/holes and/or small micropore/micropores formed on the radial surfaces of the catheter contacting to the vessel and since the barrier-end is used at the end of the delivery catheter, the success rate of the treatment is increased by applying embolization agent to the main vein from a distance as close as possible.
  • Another aim of the invention is to increase the level of safety by enabling more efficient use of developing embolization agent delivery systems.
  • Figure-3 Cross-sectional view of the gun used in the delivery system of the Barrier-ended Embolization Agent
  • Figure-4 Illustrations showing the stages of the Barrier-ended Embolization Agent delivery system
  • Figure-5 The application illustration of Barrier-tipped Embolization Agent delivery system on human body
  • Embolization agent delivery systems primarily consists of an intervention catheter that is sent into the vessel and delivery catheter passing through this intervention catheter. While the intervention catheter serves as a guide within the vessel to be treated, the delivering catheter transmits the embolization agent to vessel be treated.
  • the embolization agent (13) is dispensed into the vessel with a gun (12) wherein the said gun (12) consists of embolization injection reservoir (7) integrated with delivering catheter (1), trigger (8), pusher (9), reservoir pusher stabilizer (10), injection gun safety lock (11) .
  • the intermediate butterfly apparatus (6) and locked injection link connector (5) which provide catheter positioning, also connect the gun with delivery catheter (1) and the intervention catheter (4) each other.
  • the main focus of the present invention is the structural characteristics of the delivery catheter (1) and the improvements made on the delivery catheter (1) .
  • the end of delivering catheter (1) is closed in the horizontal plane, and owing to the micropores (3) hole and/or diameter of which is on micron-level, an embolization agent (13) delivery system which spreads not with a forward linear/horizontal/flat angle but with a vertical angle to surface of vessel and which is preferably 360 degrees radial.
  • the barrier (2) is located to close the end of the delivery catheter (1) .
  • the barrier-end (2) which serves as an ultrasonographic and angiographic marker, is capable of closing the end of the delivery catheter (1), prevents the embolization agent (13) from transmitting forward and allows the position of delivery catheter (1) to be clearly visible under the ultrasonography/angiography.
  • the barrier-end (2) of the delivery catheter (1) can be manufactured as metal suitable for treatment, stainless steel, cobalt-chromium, nitinol (nickel-titanium) or titanium based. Other suitable metals are also within the scope of this invention.
  • the front end of the barrier- end (2) has a rounded elliptical, soft end to provide easy orientation within the vessel and to prevent possible unwanted injuries and ruptures in the vessel that can be caused by the end portion of the delivery catheter (1), and to provide more effectively moving of the delivery catheter (1) in the vascular access. It is suggested that the length of the barrier-end (2) is preferably less than 4 cm, in order to provide the required effectiveness .
  • holes and/or micropores (3) diameter of which is micron level which provide continuous and preferably circular transmission on the delivery catheter (1) are holes and/or micropores (3) diameter of which is micron level which provide continuous and preferably circular transmission on the delivery catheter (1) .
  • This section in which the hole and/or micropores (3) are located preferably starts from the point where the barrier-end (2) is connected to the delivery catheter (1) and continues for 2 cm. However, this length can be increased or decreased according to the treatment.
  • These holes and/or micropores (3) are preferably positioned so as to surround the entire circumferential surface of the delivery catheter by 360 degrees. However, it is also within the scope of the present invention that they are positioned only at a suitable location on the top, side, or bottom of the delivery catheter (1) .
  • the diameter of the micropores (3) is preferably 300 microns, the micropore (3) may vary according to the size of the vessel to be treated and the fluidity of the embolization agent.
  • the geometric structures of the micropores (3) or holes may optionally vary, and round or elliptical micropores are preferred to minimize clogging .
  • the intervention catheter (4) is preferably made of PTFE (polytetrafluoroethylene ) . It can also be manufactured from any material that is biocompatible and will not allow degradation of the structure.
  • the intervention catheter is first delivered into the vessel to be treated, then the delivery catheter (1) is delivered into the vessel so as to pass through the intervention catheter (4) . After the catheters are placed in the vessel, they are connected to the gun (12) to deliver the embolization agent. When the trigger (8) of the gun (12) is pulled, the embolization agent (13) is delivered through the delivering catheter (1) to the vessel.
  • the barrier end (2) located at the end of the delivery catheter (1) is observed by ultrasonic and the delivering catheter (1) and is stopped when it reaches desired point.
  • the barrier-end (2) is closely monitored with ultrasound to achieve the nearest treatment where the vessel to be treated is joined with the main artery and it can be approached to the main artery as the size of the barrier-end (2) (1 cm or less) owing to the barrier-ended delivery system.
  • the safety lock (11) of the gun is opened and the trigger (8) is pulled and the embolization agent (13) moves towards the delivery catheter (1) .
  • embolization agent (13) When the embolization agent (13) is reached to the barrier-end (2) located at the end of the delivery catheter (1), the horizontal move in the catheter (1) finishes behind the barrier- end (2) and embolization agent (13) starts to spread into the vessel through the holes and/or micropores (3) located on the delivery catheter (1) .
  • the implantation of the embolization agent (13) to the vessel not only from one point but from a plurality of different points is ensured while the holes and/or micropores (3) are preferably all over the surface of the delivery catheter (1) . In this respect, as well as providing the agent (13) interface to the entire surface of the vessel, not just one surface of the vessel, the main vein/artery occlusion and risks that can create serious complications are also prevented.
  • the system that is subject of the invention essentially comprises separate delivery (1) and intervention catheter (4), wherein the use of an integrated single catheter as a barrier-ended agent delivery system by integrating these two catheters under a single structure is also within the scope of this invention.

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne une extrémité de barrière en acier (2) qui a été développée pour fournir un traitement par réalisation d'une embolisation (agent d'embolisation de processus de colmatage) dans des varices, des veines perforantes et des maladies vasculaires collatérales résultant d'une dilatation vasculaire extrême dans l'organisme vivant ou dues à une détérioration de la structure anatomique existante du vaisseau, et qui sert de marqueur échographique et angiographique, et concerne un système de distribution d'agent radial comprenant des micropores qui assurent une transmission continue et circulaire. En particulier, la présente invention concerne la réalisation d'une embolisation circulaire à 360 degrés et la prévention de complications qui peuvent se produire pendant un étalement vers l'avant en empêchant une transmission vers l'avant appliquée dans des systèmes antérieurs, au moyen d'une extrémité de barrière en acier qui sert de marqueur ultrasonographique et angiographique parmi les composants du système et les micropores qui assurent une transmission circulaire continue et pour empêcher une injection de zone erronée en réalisant une localisation plus facile au moyen d'une plus grande échogénicité sous ultrasons et de systèmes angiographiques et pour fournir un fonctionnement plus efficace du système et une efficacité accrue.
PCT/TR2017/050194 2016-12-08 2017-05-15 Système de distribution d'agent d'embolisation à extrémité de barrière WO2018106202A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2016/18140A TR201618140A2 (tr) 2016-12-08 2016-12-08 Bariyer Uçlu Embolizan Ajan Teslim Sistemi
TR2016/18140 2016-12-08

Publications (1)

Publication Number Publication Date
WO2018106202A1 true WO2018106202A1 (fr) 2018-06-14

Family

ID=59969208

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2017/050194 WO2018106202A1 (fr) 2016-12-08 2017-05-15 Système de distribution d'agent d'embolisation à extrémité de barrière

Country Status (2)

Country Link
TR (1) TR201618140A2 (fr)
WO (1) WO2018106202A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004022153A2 (fr) * 2002-09-05 2004-03-18 Genentech, Inc. Catheter d'infusion dote d'un transducteur doppler integre
WO2013019947A2 (fr) * 2011-08-03 2013-02-07 Venous Therapy, Inc. Ensembles, systèmes et procédés de perfusion d'agents thérapeutiques dans le corps
EP2656869A1 (fr) * 2012-04-24 2013-10-30 angioclinic AG Dispositif pour traiter les insuffisances veineuses et veines variqueuses
US20140142494A1 (en) * 2009-10-06 2014-05-22 Michael P. Wallace Methods and devices for endovascular therapy
EP2741804A2 (fr) * 2011-08-11 2014-06-18 Osprey Medical Inc. Système et procédé de traitement des membres
US20150164573A1 (en) * 2011-06-30 2015-06-18 Angiodynamics, Inc. Endovascular plasma treatment device and method of use
US20160256170A1 (en) * 2012-06-25 2016-09-08 Rany Busold Systems and methods for the treatment of aneurysms

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004022153A2 (fr) * 2002-09-05 2004-03-18 Genentech, Inc. Catheter d'infusion dote d'un transducteur doppler integre
US20140142494A1 (en) * 2009-10-06 2014-05-22 Michael P. Wallace Methods and devices for endovascular therapy
US20150164573A1 (en) * 2011-06-30 2015-06-18 Angiodynamics, Inc. Endovascular plasma treatment device and method of use
WO2013019947A2 (fr) * 2011-08-03 2013-02-07 Venous Therapy, Inc. Ensembles, systèmes et procédés de perfusion d'agents thérapeutiques dans le corps
EP2741804A2 (fr) * 2011-08-11 2014-06-18 Osprey Medical Inc. Système et procédé de traitement des membres
EP2656869A1 (fr) * 2012-04-24 2013-10-30 angioclinic AG Dispositif pour traiter les insuffisances veineuses et veines variqueuses
US20160256170A1 (en) * 2012-06-25 2016-09-08 Rany Busold Systems and methods for the treatment of aneurysms

Also Published As

Publication number Publication date
TR201618140A2 (tr) 2018-06-21

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