WO2018101943A1 - Système et procédé d'inactivation de pathogènes à l'aide de lumière visible et/ou de lumière uv - Google Patents

Système et procédé d'inactivation de pathogènes à l'aide de lumière visible et/ou de lumière uv Download PDF

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Publication number
WO2018101943A1
WO2018101943A1 PCT/US2016/064352 US2016064352W WO2018101943A1 WO 2018101943 A1 WO2018101943 A1 WO 2018101943A1 US 2016064352 W US2016064352 W US 2016064352W WO 2018101943 A1 WO2018101943 A1 WO 2018101943A1
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WIPO (PCT)
Prior art keywords
light
light source
inactivation
power state
area
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PCT/US2016/064352
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English (en)
Inventor
Peter Gordon
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LiteProducts LLC
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Priority to PCT/US2016/064352 priority Critical patent/WO2018101943A1/fr
Publication of WO2018101943A1 publication Critical patent/WO2018101943A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/24—Apparatus using programmed or automatic operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/26—Accessories or devices or components used for biocidal treatment

Definitions

  • the present application relates to the inactivation of pathogens using visible light and/or UV light.
  • Infectious diseases are caused by various pathogens: vegetated bacteria, bacterial spores, virions, fungus, etc. Once upon or within the body they replicate and can cause an infection and illness, sometimes resulting in death.
  • Pathogens act by entering the body through openings, by way of contaminated food, fomites, and aerosolized pathogens in air or on dust, human contact with pathogen contaminated surfaces, or human-to-human contact.
  • the contaminated hands of healthcare workers in hospitals and clinics are a significant vehicle for transmission of infectious pathogens to patients. Hands are invariably contaminated by contact with surfaces that are typically contaminated; usually unavoidably. This is especially common in hospitals. As a result in the US of order 7% of patients acquire infectious diseases as a result of a hospital stay and approximately 100,000 die annually. Worldwide infection statistics are equally dismal.
  • Typical washing of hands and forearms is capable of removing a fraction of the transient pathogens of all kinds on or near the skin surface, whereas alcohol rubs as noted are ineffective on spores such as C. difficile, which annually kill 21,000 hospital patients.
  • Each technique has inadequacies such as: 1) elimination or reduction to 10-4 of the original number of active pathogens, technical sanitation, is seldom accomplished or assured; 2) the conventional techniques do not uniformly cover 100% of the area supposedly sanitized; and 3) the conventional techniques are not always possible or convenient to implement for multiple reasons. The result is a variable rate of disinfection compliance between patient visits, usually less than 50%, and there is uncertainty in achieving technical sanitation when it is implemented.
  • Extended application time improves the protection. For example, surgeons scrub their hands for many minutes to improve the percentage of pathogens removed. Nurses and other healthcare workers with far less time available wash their hands for about 60 seconds, many times daily, and as a result, cause their hands become painfully sore and chapped; thereby making it difficult to use the hand wash technique consistently.
  • bare hand sanitation is inconsistently applied. It is estimated that bare hand sanitation is practiced less than 40% of the time between patient visits, and generally not at all during the patient visit.
  • the classic explanations for non-compliance are: 1) inadequate time given the busy schedules of the healthcare workers, and 2) hand irritation. Although requiring less time and being less irritating, the use of alcohol rub does not significantly improve the compliance rate.
  • the contaminated hand, bare or gloved is a major vehicle for transmission of pathogens to the patient and is believed to be the primary vehicle for spread of hospital acquired infections. Furthermore, it is generally understood that the purpose of the gloves is to protect the healthcare worker from the patient, not the patient from the healthcare worker. Gloves are not typically washed. Hence, the use of gloves has little or no impact on the patient infection problem and provides no protection for the patient. Surgical gloves are nominally sterile but sterility is not guaranteed.
  • Washing hands is typically not practiced as frequently as desired or in an adequate manner. Moreover, in many developing countries, the sanitary and hygienic conditions at schools are often very poor, and can be characterized by the absence of properly functioning or existing water supply for sanitation or hand washing facilities. . [0014] Sanitary hands in take-out food service or restaurant settings are similarly critical to prevent the spread of disease. The FDA reports that poor personal hygiene in a food service environment is a critical area that needs immediate attention and sets the following requirements with respect to personal hygiene: 'Proper and adequate hand-washing, prevention of hand contamination, good hygienic practices, and a hand-washing facility that is convenient and accessible, with cleanser/drying devices.'
  • one or more LED light sources located in ceiling fixtures illuminate the entire room. Over a period of order 24 hours it reduced bacterial counts by a factor of less than ten. Given the amount of time required and the amount of bacterial inactivation, these devices and techniques would be inadequate for pathogen inactivation in a faster paced, higher traffic, clinical or commercial setting where more rapid results are required.
  • a system for inactivation of pathogens within an inactivation area on a surface may include a first light source that emits first light having a peak wavelength in a range of 400 nm to 500 nm; a second light source that second emits light having a peak wavelength in a range of 185 nm to 400 nm; and control electronics configured to control a first power state of the first light source and a second power state of the second light source.
  • the first power state and the second power state may be independently controlled.
  • An illumination area of the first light and an illumination area of the second light may be limited to the inactivation area.
  • a method of inactivating pathogens within an inactivation area on a surface may include providing a system include a first light source that emits first light having a peak wavelength in a range of 400 nm to 500 nm, a second light source that emits second light having a peak wavelength in a range of 185 nm to 400 nm, and a light guide structured to direct the first light and the second light to the inactivation area; setting a first power state of the first light source to an on state; aiming the light guide so that the first light illuminates the inactivation area; and setting the second power state of the second light source to an on state.
  • An illumination area of the first light and an illumination area of the second light may be limited to the inactivation area.
  • a system for inactivation of pathogens on a surface may include a first light source that emits first light having a peak wavelength in a range of 185 nm to 500 nm; a second light source that emits second light that is visible light; and control electronics configured to control a first power state of the first light source and a second power state of the second light source.
  • the first power state and the second power state may be independently controlled.
  • the second light source may be configured to emit light in a predetermined pattern that indicates an inactivation area to be illuminated.
  • the system may configured such that an illumination area of the first light is limited to the inactivation area.
  • Figure 1 is a schematic front view of an embodiment of a device for inactivation of pathogens.
  • Figure 2 is a schematic front view of an embodiment of a device for inactivation of pathogens.
  • Figure 3 is a cross-sectional schematic side view of an embodiment of a device for inactivation of pathogens.
  • Figure 4 is a cross-sectional schematic side view of an embodiment of a device for inactivation of pathogens.
  • Figure 5 is a schematic front view of an embodiment of a device for inactivation of pathogens.
  • Figure 6 is a schematic front view of an embodiment of a device for inactivation of pathogens.
  • Figure 7 is a cross-sectional schematic side view of an embodiment of a device for inactivation of pathogens.
  • Figure 8 is a perspective view of an embodiment of a device for inactivation of pathogens.
  • Figure 9 is a perspective view of an embodiment of a device for inactivation of pathogens.
  • Figure 10 is a side view of an embodiment of a device for inactivation of pathogens.
  • Figure 11 is a schematic perspective view showing a possible use of an embodiment of a device for inactivation of pathogens.
  • Figure 12 is a perspective view showing a possible mounting of an embodiment of a device for inactivation of pathogens.
  • Figure 13 is a side view showing a possible mounting of an embodiment of a device for inactivation of pathogens.
  • Figure 14 is a perspective view of an embodiment of a device for inactivation of pathogens.
  • Figure 15 is a perspective view showing an embodiment of hand placement verification for use in an embodiment of a device for inactivation of pathogens.
  • Figure 16 shows graphs of the output of an embodiment of hand placement verification for use in an embodiment of a device for inactivation of pathogens.
  • Figure 17 shows a schematic view of an embodiment of a handheld device for inactivation of pathogens.
  • Figure 18 is a top planar view of an embodiment of a handheld device for inactivation of pathogens.
  • Figure 19 is a perspective view of an embodiment of a device for inactivation of pathogens on a surface.
  • Figure 20 is a perspective view of an embodiment of a device for inactivation of pathogens on a surface.
  • Figure 21 is a perspective view of one possible use of an embodiment of devices for inactivation of pathogens on a surface.
  • Figure 22 is a view an embodiment of a system for inactivation of pathogens.
  • Figures 23 is a view an embodiment of a system for inactivation of pathogens.
  • Figure 24 is a perspective view of an embodiment of a system for inactivation of pathogens for use with a food service table.
  • Figure 25 is a view of an embodiment of a system for inactivation of pathogens for use with a public terminal.
  • Figure 26 is a view of an embodiment of a system for inactivation of pathogens.
  • Figure 27 is a view of an embodiment of a system for inactivation of pathogens.
  • Figure 28 is a flowchart of an embodiment of a method for inactivation of pathogens.
  • Figure 29 is a flowchart of an embodiment of a method for inactivation of pathogens.
  • Figures 30 is a flowchart of an embodiment of a method for inactivation of pathogens.
  • Figure 31 is a view of an embodiment of a system for inactivation of pathogens.
  • Figures 32 is a view of an embodiment of a system for inactivation of pathogens.
  • Figures 33 is a view of an embodiment of an inactivation area and an aiming pattern.
  • Figures 34 is a view of an embodiment of an inactivation area and an aiming pattern.
  • Figures 35 is a view of an embodiment of an inactivation area and an aiming pattern.
  • Figures 36 is a view of an embodiment of an inactivation area and an aiming pattern.
  • Figures 37 is a view of an embodiment of an inactivation area and an aiming pattern.
  • Figures 38 is a view of an embodiment of an inactivation area and an aiming pattern.
  • Figure 1 shows a front view of at least one embodiment of a device for inactivation of pathogens on an object.
  • the device may include a main body 100 defining an internal space 110.
  • a first light source 120 may be provided on a first internal surface 130 of main body 100.
  • Internal space 110 accommodates the object 140.
  • First light source 120 may emit light having a wavelength in the range of 400 nm to 500 nm.
  • Figure 2 shows a front view of at least another embodiment of a device for inactivation of pathogens on an object.
  • a second light source 222 may be provided on a second internal surface 232 of main body 100.
  • second internal surface 232 and second light source 222 are opposite of first internal surface 220 and first light source 222.
  • the first light source 220 and second light source 222 may emit light having a wavelength in the range of 400 nm to 500 nm.
  • internal surfaces 230, 232, 234, 236 of main body 200 are reflective.
  • Figure 3 shows a side cross-section view of the embodiment shown in Figure
  • the main body 200 is a cylinder, column, or box shape that is open on a first end 250 and a second end 260.
  • Figure 4 shows another embodiment of a side cross-section view of the embodiment shown in Figure 2. In the embodiment shown in Figure 4, the main body 200 is open on a first end 250 and closed on a second end 260.
  • the object 240 is a hand.
  • the device is not limited to inactivating pathogens on only hands.
  • any suitable object such as instruments, utensils, trays, dishes, glassware, lab equipment, or any other object that fits inside the device can be subject to pathogen inactivation.
  • Figure 5 illustrates another embodiment of a device for inactivation of pathogens on an object.
  • Light sources 320, 322, 324, 326 emit light having a wavelength of 400 nm to 500 nm, internal surfaces 330, 332, 334, 336 are reflective.
  • the device is not limited to a rectangular or cubic shape.
  • Figure 6 shows an embodiment in which the main body 400 has an elliptical cross section, and a plurality of light sources 420 provided on an internal surface 430 of main body 400.
  • the cross section of the main body of the device can have any suitable shape, such as rectangle, ellipse, circle, or other polygon or curved shape.
  • D represents the distance between first light source 220 and second light source 222. In at least one embodiment, distance D is 20 cm or less. In another embodiment, distance D is 10 cm or less. In yet another embodiment, distance D is 5 cm or less.
  • any of the light sources discussed above can comprise an array of LEDs.
  • the LED array may be formed from InGaN LEDs, which emit light in the range of 400-500 nm.
  • the device is not limited to InGaN LEDs, as any LED that emits light in the range of 400-500 nm can be used.
  • the various light sources emit light having a wavelength in the range of 400-500 nm. It will be understood that in addition to this range, at least an embodiment of the device will have light sources that emit light having a wavelength in the range of 400-410 nm. It will be further understood that at least an embodiment of the device will have light sources that emit light having a wavelength in the range of 404-406 nm. It will be further understood that at least an embodiment of the device will have light sources that emit light having a wavelength of approximately 405 nm.
  • the light source will emit light only within the specified range.
  • the light sources emit only light having a wavelength in the range of 400-500 nm.
  • at least an embodiment of the device will have light sources that emit only light having a wavelength in the range of 400-410 nm. It will be further understood that at least an embodiment of the device will have light sources that emit only light having a wavelength in the range of 404- 406 nm. It will be further understood that at least an embodiment of the device will have light sources that emit only light having a wavelength of approximately 405 nm.
  • the effectiveness of the device in inactivating pathogens on the object depends on the dose of light irradiated on the object. For example, a total dose of 30 J/cm2 is adequate for 10-4 (i.e. 99.99%) inactivation of MRSA pathogens. This dose would be sufficient to achieve the standard of sanitation, which is defined as inactivation of 99.99% of pathogens. This dose could be achieved in 30 seconds of time when the irradiance of the object is 1 W/cm2. The time of necessary exposure can be varied by changing the irradiance of the object. For example, 30 seconds exposure may be inconvenient in some applications.
  • the irradiance of the object depends on the power of the light source and the area over which the light is directed. For example, if the target field for the object is 1000 cm2, then the light sources would need to have a power of 1000 watts to achieve 1 W/cm2 irradiance.
  • Figures 8-14 show various embodiments of a device for inactivation of pathogens.
  • Figure 8 shows a device 500 that includes two slots 510 through which hands or other objects can be inserted.
  • Device 500 may include interface 520.
  • Interface 520 may include indicator lights that can indicate when an object is inserted into the device and when a sufficient time for the desired inactivation has passed.
  • Interface 520 may also include controls to allow a user to modify the power output of the device, desired exposure time, change modes, or perform other suitable functions.
  • Figures 9-10 show another embodiment of a device 600 for inactivation of pathogens.
  • the slots 610 are placed side by side in a horizontal arrangement. This may allow for the sharing of some components between the two slots 610.
  • Device 600 may further include an interface 620 that may include indicator lights, controls, and/or digital displays.
  • device 600 may have a top panel 630 that can be opened via hinge 632 to allow for easy cleaning and maintenance of device 600.
  • Figure 11 shows a schematic view of how a device 600 can be arranged vertically for a smaller footprint, thereby saving space.
  • a vertical arrangement of device 600 may be more comfortable for a variety of users 650.
  • Figure 12 shows how a device 600 can be mounted vertically on a pole mount 680.
  • Figure 13 shows that the pole mount 680 may be wheeled so that the device can be easily and conveniently moved to wherever pathogen inactivation is needed.
  • Figure 14 shows another embodiment of a device 700 for inactivation of pathogens in which the slots 710 are arranged vertically instead of horizontally. The vertical arrangement of slots 710 may be more comfortable for certain users in certain configurations.
  • a device may include a sensor 800 such as a photodiode array at an appropriate position inside the device, as seen in Figure 15.
  • a sensor 800 such as a photodiode array
  • Figure 16 shows a graph 900 showing a projected output of the sensor 800 with no hand present.
  • a hand is inserted, perhaps triggering a movement sensor to initiate the sanitation episode, and fingers are properly spread, the output of the sensor 800 will have a predictable variation in its shape, as shown in graph 910.
  • a processor can determine whether the hands are in a proper position. Proper positioning can be acknowledged to the user by using an indicator light, a display, an audio cue, or other suitable sensory stimulus.
  • one advantage of the device over conventional methods of surface pathogen in activation is that the light can be delivered consistently over 100% of a user's hand with no required input from the user. This is a marked advantage over soaps or alcohol rubs, where the uniformity of exposure depends on the diligence of the user, and even there areas such as under fingernails or in cracks of skin may be missed.
  • Embodiments of the device could be used in commercial settings such as restaurants, food preparation, veterinary, animal husbandry, laboratories, public restrooms, day care centers, educational facilities, etc. Not only would these uses reduce contamination and infection, but they would also be environmentally friendly by reducing water use, chemicals from soap use, and paper towel waste.
  • Figure 17 shows a schematic of an alternative embodiment in which the device is a portable, handheld device that can be carried on a person and used for pathogen inactivation whenever desired.
  • the device may include a main body 1000, a light source 1010, a power source 1020 such as a rechargeable battery or other suitable power source, control electronics 1030, and user interface 1040.
  • the light source 1010 emits light having a wavelength in a range of 400-500 nm.
  • the light source 1010 may emit light having a wavelength in a range of 400-410 nm, in a range of 404-406 nm, or having a wavelength of approximately 405 nm.
  • light source 1010 may emit light having a wavelength in a range of 465-475 nm, in a range of 469-471 nm, or having a wavelength of approximately 470 nm for a lower cost alternative to the 405 nm light sources.
  • the light source 1010 may include a light source that emits only light having a wavelength of in the range of 400-500 nm, only light having a wavelength of in the range of 400-410 nm, only light having a wavelength of in the range of 465-475 nm, only light having a wavelength of in the range of 404-406 nm, only light having a wavelength of in the range of 469-471 nm, only light having a wavelength of approximately 405 nm, or only light having a wavelength of approximately 470 nm.
  • Light source 1010 may be provided inside of main body 1000, and main body 1000 can be formed of a transparent material. Alternatively, light source 1010 may be provided on an exterior surface of main body 1010. Additionally, light source 1010 may include a plurality of light sources. For example, as seen in Figure 18, a device may have a transparent main body 1100 with multiple light sources 1110 provide therein.
  • Control electronics 1030 may be structured to control supply of power from power source 1020 to light source 1010. Control electronics 1030 can control the light source 1010 to turn on for a set period of time. Additionally, control electronics 1030 can cause light sources 1010 to turn on and off at a predetermined frequency and duty ratio. The flickering of light sources 1010 can enhance the user experience to show that the device is working.
  • Control electronics 1030 may be controlled by user interface 1040.
  • User interface 1040 may take the form of a pressure sensor, dial, knob, button, switcher, slider, or any other suitable structure. User interface 1040 may be used by the user to control the activation time of the device, modes of the device, frequency or duty ratio of the flickering light, or other functions.
  • the control electronics 1030 may serve to activate indicator lights, sound, vibration or other sensory stimulus to remind a user when to use the device. Additionally, the control electronics may include communication circuits to allow the device to link with smart phones or other devices, which could allow the user to track use of the device for pathogen inactivation or set reminders of when to use the device, such as prior to meal times, before or after leaving work, during children activities, etc.
  • the handheld devices can be easily used in the home, in the car/bus/train /plane, at work, at restaurants, in the gym, and anywhere else a user may go.
  • the handheld devices may also be particularly useful for outdoors activities, such as camping, hiking, boating, fishing, hunting, etc., where a user may be exposed to a variety of pathogens, but does not have ready access to clean water and soap.
  • main body 1000 can take a variety of forms.
  • the main body may be formed in the approximate size and shape as a bar of soap. This will reinforce the function of the device to the user, for example, but encouraging the user to rub the device over their hands as they would a bar of soap when pathogen inactivation on the hands is desired.
  • an embodiment of the device could be realized in the cover or body of a cell phone, for example, allowing for inactivation of pathogens without having to carry an alternative device.
  • an embodiment of the device could be realized in the body of a brush, which could then be used for brushing pets or other animals to inactivate pathogens on their skin during grooming.
  • transparent accoutrements where pathogens reside and be transferred from the surface to hands, food or water can be configured to accommodate sanitation capabilities.
  • an embodiment of the device can be made so that an outer surface is waterproof.
  • the handheld device could be used under running water in lieu of traditional soap.
  • a waterproof handheld device could be used in dental applications, by being incorporated into a toothbrush or other dental appliance to help supplement traditional brushing in flossing to inactivate the pathogens that cause halitosis and gingivitis.
  • the amount of pathogens inactivated by visible light will vary with the power of the light and the length of exposure.
  • the goal is to achieve at least 90% inactivation of pathogens, which is similar to the efficacy of store-bought commercial hand cleansers based on common usage patterns
  • the power of the light source 1010 in the handheld device will depend on the desired inactivation time and the geometry of the device. For example, if the handheld device is a sphere with radius of 4 cm, having a light source at the center, and 10 second inactivation (i.e., irradiance of 90 mW/cm2) is desired, then the light source will need to emit approximately 18.1 W of light. In more complicated geometries, it will be understood that it will be more difficult to achieve a uniform irradiance at an outside surface of the handheld device. Accordingly, given that a user will be rubbing the device back and forth in their hands or over an object, one can consider an average irradiance at an outer surface of the device.
  • a challenge suspension of Staphylococcus aureus containing approximately 109 CFU/mL was prepared in 0.9% Sodium Chloride Irrigation, USP.
  • a total of eight sterile stainless steel coupons 3 inches x 3 inches in size were each contaminated with a 0.1 mL aliquot of the challenge suspension and dried at 35 degrees C for approximately 15 minutes.
  • Six of the contaminated coupons were individually exposed within an antimicrobial light box for five minutes. Each coupon was maintained in a horizontal position, contaminated-side up, during the exposure period. Three of the six coupons were exposed at a distance of approximately 3 inches below the upper bulbs. Inside the light box, the coupons were exposed to 405 nm light at an approximate irradiance of 3 mW/cm2.
  • treated coupons #l-#3 were placed approximately 1 cm from the light source, and treated coupons #4-#6 were placed approximately 3 inches from the light source.
  • the tables above show that the 5 minute exposure of light was successful in reducing the number of pathogens by approximately a factor of 10, i.e., a 90% reduction.
  • Figures 19-21 show an embodiment of a device and method for inactivating pathogens on a surface.
  • Figure 19 shows a device 1200 having a hood 1220 and a light source 1210 provided within hood 1210.
  • the light source 1210 is not directly shown, but the reference numeral 1210 indicates the approximate position where the light source is located inside of hood 1220.
  • Hood 1210 can be internally reflective and structured to direct the light at a surface where pathogen inactivation is desired.
  • Figure 20 shows another embodiment in which a light source can be provided in a structure 1300 having articulated arms 1310 and joints 1320, to aid in directing the light exactly where it is desired.
  • An embodiment of the hood 1210 may be realized by an unfurling mechanism similar to an umbrella. Inside surfaces of the hood 1210 could be coated or formed of a reflective material, to help ensure that as much light as possible is directed to the target surface. Additionally, reflectors can be provided behind the light source for the same purpose of directing as much light as possible to the target surface.
  • light source 1210 may emit light having a wavelength in the range of 400-500nm, light having a wavelength in a range of 400-410 nm, or light having a wavelength of approximately 405 nm.
  • the light source 1210 may include a light source that emits only light having a wavelength of in the range of 400-500 nm, only light having a wavelength of in the range of 400-410 nm, or only light having a wavelength of approximately 405 nm.
  • the devices shown in Figures 19 and 20 can be used by first positioning the light source a predetermined distance from the surface for which pathogen inactivation is desired.
  • the predetermined distance depends on the geometry of the light source, any hood, and the desired area of inactivation. For example, for a desk-sized version of the device, it may be determined that the device will have an inactivation area of 1000 cm2 when positioned 30 cm away.
  • the device is not limited to this arrangement, and it will be understood that a wide variety of geometries and distances will be encompassed by the method being described.
  • the light can be aimed so that the light is directed to the area where pathogen inactivation is desired. Because the device is emitting light having a wavelength of 400-500 nm, this falls within the visible light spectrum and is not dangerous to vision or skin. Therefore, a user could turn on the light source 1210 while aiming the device so that an illuminated area will be shown to aid in aiming. [0100] Next, the device will be activated for a predetermined amount of time. As described above, the predetermined time depends on the power of the light source 1210 and the level of pathogen activation desired. Examples above have been described for achieving various levels of pathogen inactivation at varying levels of exposure time. However, it will be understood that longer or shorter activation times are possible by varying the power of the light source, and that these are encompassed within the scope of the device and method described herein.
  • Present Figure 21 shows at least one embodiment of how devices 1200 may be used.
  • one or more devices 1200 may be provided around an operating table, and be continuously turned on to provide persistent pathogen inactivation of the surgical field during an operation.
  • at least an embodiment of the device could also be realized in the form of a light "faucet” or light “shower” to be used, for example, for surface pathogen inactivation of one's hands or body after working in a contaminated environment without requiring the use of water, which could be useful in locations where water supplies are scarce.
  • at least an embodiment of the device could be implemented in conjunction with traditional water showerheads and faucets, providing supplemental pathogen inactivation due to the light exposure at the same time as the hand washing or showering.
  • an embodiment of the device can be used for persistent inactivation of pathogens of a works surface such as a food preparation area or a laboratory workspace.
  • the embodiments described above have a number of advantages over conventional methods of surface pathogen inactivation. For example, the devices and methods above achieve a much higher level of pathogen inactivation than conventional visible light pathogen inactivation techniques in a much shorter time. Additionally, as compared with traditional methods of soap-and-water or alcohol rub pathogen inactivation, the embodiments described above will result in less skin irritation while providing a more uniform pathogen inactivation of hands and other surfaces. Additionally, because the embodiments described above use visible light, there is no danger to vision or skin. In fact, the use of 405 nm light may have anti-aging and anti- wrinkle properties.
  • the handheld embodiments described above provide a convenient way for consumers to experience similar benefits of surface pathogen inactivation in a portable form, without experiencing the negative skin effects of traditional hand rubs.
  • the device described above is useful for inactivating pathogens on hands or other small objects that can be inserted into the device.
  • continuous pathogen inactivation may be desired on a surface that is impractical for insertion into a device.
  • prep areas such as counters or service areas such as salad bars are constantly exposed to a variety of pathogens throughout the day, as well as food that is left out on a salad bar or buffet.
  • work stations or counters in labs or research field stations may be exposed to pathogens.
  • Figure 22 shows an embodiment of a system 1500 for directing light to a surface for inactivating pathogens within an inactivation area IA.
  • the inactivation area IA is an area within which a user desires inactivation of pathogens. Even though inactivation area IA appears one-dimensional because of the planar nature of Figure 22, it will be understood that inactivation area IA is actually two-dimensional.
  • the system 1500 may include a first light source 1502 that emits first light having a peak wavelength in a range of 400 nm to 500 nm.
  • first light source 1502 may emit first light having a spectrum with a peak wavelength in a range of 400 nm to 410 nm or in a range of 450 nm to 470 nm.
  • a peak wavelength of the first light is approximately 405 nm.
  • the first light may have a spectrum with a full width at half maximum height of approximately 10 nm or less.
  • the first light source 1502 may emit visible blue light that has pathogen inactivation properties as described above.
  • the system may include a second light source 1504 that emits second light having a spectrum with a peak wavelength in a range of 185 nm to 400 nm.
  • the spectrum of the second light may have a peak wavelength in a range of 240 nm to 280 nm.
  • the second light may have a spectrum with a peak wavelength of approximately 254 nm, 260 nm, or 275 nm.
  • the second light may have a spectrum with a full width at half maximum height of approximately 10 nm or less.
  • the second light source 1504 may emit UV light.
  • the inactivation area IA of the system may have an area of 10 square feet or less. However, it will be understood that the area is not limited to this value, and other sized areas may be used as well. In at least another embodiment, such as used with a salad bar, buffet table, or countertop, the inactivation area may have a significant length, but it will have a width of 4 feet or less. However, it will be understood that the area is not limited to this value, and other sized areas may be used as well. It will also be understood that an illumination area of the first light and an illumination area of the second light are limited to be substantially within the inactivation area. This insures that as much power as possible is being directed towards the desired inactivation area.
  • the inactivation area IA may be any variety of shape as required by the particular application.
  • inactivation area IA may be square, rectilinear, polygonal, circular, elliptical, or any other two-dimensional shape.
  • the inactivation area is not required to be planar.
  • the light used for pathogen inactivation can track the contours of a three-dimensional surface, such as lab equipment, serving trays/bowls, food items on display, human body parts during medical procedures, or any other three-dimensional surface that requires pathogen inactivation.
  • the system may also include control electronics 1506 that are operably connected with the first light source 1502 and the second light source 1504.
  • the control electronics 1506 are configured to control a first power state of the first light source 1502 and a second power state of the second light source 1504.
  • the first power state may be switchable between an ON state and an OFF state
  • the second power state may be switchable between an ON state and an OFF state.
  • the first power state and the second power state may be controlled independently of each other.
  • the first power state may be set to the ON state while the second power state may be set to the OFF state, or vice versa.
  • the first power state and the second power state may also include a range of power.
  • the first power state and the second power state may be independently set at anywhere from 0% to 100% of full power.
  • the first light source 1502 and the second light source 1504 may take a number of forms.
  • the first light source 1502 and the second light source 1504 may be configured out of low pressure lamps, high pressure lamps, cold-cathode lamps, arrays of LEDs, or other sources of light capable of emitting light of the desired spectrum.
  • first light source 1502, the second light source 1504, and the control electronics 1506 are not limited to what is shown in Figure 22. Instead, Figure 22 merely shows the first light source 1502, the second light source 1504, and the control electronics 1506 as a block diagram, and any suitable arrangement of these structures is possible.
  • first light source 1502 and the second light source 1504 may be provided.
  • the first light source 1502 and the second light source 1504 may be placed on the end of an articulated arm 1510.
  • a light guide such as hood 1520 can be provided to direct as much light as possible from the first light source 1502 and the second light source 1504 to the target inactivation area.
  • the light guide may have a reflective inner surface so that as much energy as possible is transmitted from the light sources to the inactivation area. It will be understood that the light guide is not limited to the hood 1520 shown in Figure 22.
  • articulated arm 1510 allows for the light to be aimed at whatever surface requires inactivation of pathogens.
  • the system 1530 may include first light source 1532, second light source 1534, and control electronics 1536 provided in a light fixture 1540 provided on a surface and aimed at the work area for which pathogen inactivation is desired.
  • the light fixture 1540 could be fixed to the lower surface 1552 of a cabinet 1550 above a work table 1560.
  • systems 1570 could be provided on a panel 1572 of a salad bar or food display case and aimed to emit light at the food display area 1574. Because the systems 1570 include a first light source and a second light source as described above, there are a number of ways the systems 1570 could be used to inactivate pathogens.
  • the systems 1570 could be controlled to emit both light with a peak wavelength in the range of 240 nm to 280 nm (i.e., UV light) and light with a peak wavelength in the range of 400 nm to 410 nm (i.e., germicidal blue light)
  • systems 1570 could be controlled to emit just the germicidal blue light, or the germicidal blue light with lower levels of UV light so as not to exceed safe exposure levels of UV light.
  • Figure 25 shows an embodiment in which a system 1582 is attached to a public terminal 1580 such as an ATM machine or ticket dispenser.
  • a public terminal 1580 such as an ATM machine or ticket dispenser.
  • the pathogen inactivation system described above may be used to inactivate pathogens on lab tables, food preparation areas, food display areas including food, medical facilities such as examination tables or operating theaters, lavatory fixtures, door handles, or any other surface where humans may encounter pathogens.
  • Figure 26 shows an embodiment in which the pathogen inactivation system 1500 may be used in a room 1592 that has a countertop workspace 1508, such as a lab or food preparation area.
  • the system 1500 is shown using a first light source 1502 and a second light source 1504 provided on an articulated arm 1510.
  • the system may include a detector 1590 operably connected to the control electronics and configured to detect whether a person is present in the room 1592 with system 1500.
  • the detector may be operably connected to the control electronics via a wired connection or via a wireless connection.
  • the detector 1590 may take any of a number of possible forms.
  • the detector 1590 could be a motion detector configured to detect motion of a person within the room 1592.
  • the detector 1590 could be a sound detector that detects voices or other sounds associated with a person being in the room 1592.
  • the detector 1590 could be a thermal detector that detects a person in the room 1592 via body heat.
  • the detector 1590 could be a magnetic detector configured to detect opening and shutting of the door 1594.
  • the detector 1590 will send a signal to the control electronics 1506 of the system 1500, and the control electronics 1506 will be configured to determine whether a person is present in the room 1592.
  • the second power state of the second light source 1504 will be adjusted. For example, the control electronics 1506 may set the second power state to an OFF state. Alternatively, the control electronics 1506 may set the second power state to a reduced power state such that the amount of UV light to which the user is exposed is with in predetermined safety limits. Setting the second power state to a reduced power state would protect users from UV exposure while still allowing for UV light from the second light source 1504 to augment the pathogen inactivation of the visible light from the first light source 1502.
  • control electronics 1506 may include communication electronics 1506a to allow for communication with a remote terminal 1600 provide at a location 1610 remote from room 1592.
  • the remote terminal 1600 may be a personal computer, a cell phone, a tablet, or other suitable device.
  • the remote terminal 1600 may communicate with the communication electronics 1506a of the control electronics 1506 via a local wired or wireless network, via the internet, via radio waves, or by another suitable method of communication.
  • the remote terminal 1600 may be configured so that a user 1602 can determine the first power state and the second power state from outside the room 1592, i.e., without having to be physically present in the room 1592.
  • control electronics 1506 may also be configured to set the second power state to an ON state or an increased power state after a predetermined first period of time following an input from the user.
  • the user could set the control electronics 1506 to set the second power state to an ON state (i.e., turn on the second light source 1504) five minutes after a confirmation command. After issuing the confirmation command, the user could then leave the room.
  • the inactivation area IA will be illuminated with UV light five minutes later when the second power state is set to ON.
  • the control electronics 1506 may be configured to set the second power state to an OFF state after being in an ON state for a predetermined second amount of time.
  • control electronics 1506 could be configured to set the second power state to an OFF state after being in an ON state for four hours. This will reduce power consumption as well as help to protect against inadvertent exposure to UV light.
  • the control electronics may be configured to set the system 1500 into an aiming state in which the second light source 1504 is turned off and the first light source 1502 is set to emit light in a pattern that indicates the area to be illuminated.
  • the aiming state may simply be turning off the second light source and turning on the first light source, and using the visible light from the first light source as a guide to determine what area is going to be illuminated.
  • the first light source may illuminate a circular or rectilinear region in visible light, and the user would know that the UV illumination will illuminate the same region when turned on.
  • the first light source and the second light source may be arrays of LEDs. It may be necessary in some applications to center the illumination on a particular spot.
  • the LEDs of the first light source could be selectively turned on and/or shaped by a collimator to create an X pattern or a crosshairs pattern of light that could be used to locate a center of the illumination area.
  • the specific pattern in the aiming state is not limited to these examples, and other patterns may be used depending on the specific application.
  • Figures 32-37 show a series of at least some possible inactivation areas IA and aiming patterns AP formed by the first light.
  • Block 1700 illustrates a step of providing a pathogen inactivation system.
  • the pathogen inactivation system of block 1700 may include a first light source that emits light having a peak wavelength in the range of 400 nm to 410 nm, a second light source that emits light having a peak wavelength in the range of 240 nm to 280 nm, and a light guide structured to direct light from the first light source and light from the second light source to a target area.
  • Block 1702 illustrates a step of setting a first power state of the first light source to an ON state.
  • Block 1704 illustrates a step of aiming the light guide so that light from the first light source illuminates an area where inactivation of pathogens is desired.
  • Block 1706 illustrate a step of setting the second power state of the second light source to an on state.
  • the method may also include a step of continuously detecting with a detector whether a person is present in the room.
  • block 1708 illustrates a determination of whether a person is in the room. If yes, then the method proceeds to block 1710 in which the second power state is set to an OFF state. If no, then the method loops back to block 1708 to continuously determine whether a person is in the room.
  • block 1800 illustrates a step of setting a first time period.
  • it is continuously determined whether the first time period has elapsed. If no, then the method loops back to block 1802 to monitor whether the time period has elapsed. If yes, then in block 1804 the second power state is set to an ON state.
  • the method may also include setting a second period of time in block 1800. Once the second power state is set to ON in block 1804, it is determined in block 1806 whether the second time period 1806 has elapsed. If no, the method loops back to block 1806 to continue monitoring the second time period. If yes, then in block 1808 the second power state is set to OFF.
  • the system may use only one of UV light and germicidal blue light to inactivate pathogens, and use a visible light source as an aiming guide.
  • the system 1900 may include a first light source 1902 and a second light source 1904.
  • the first light source 1902 may emit first light having a peak wavelength in the range of 185 nm to 500 nm.
  • the first light may have a peak wavelength in a range of 240 nm to 280 nm, in a range of 400 nm to 500 nm, in a range of 400 nm to 410 nm, or in a range of 450 nm to 470 nm.
  • the second light source 1904 may emit second light that is visible light.
  • the system 1900 may further include control electronics 1906 configured to control a first power state of the first light source 1902 and a second power state of the second light source 1904.
  • the first power state and the second power state may be independently controlled between an ON state, an OFF state, or an intermediate state where the respective light source is supplied with less than full power.
  • the second light source 1904 may be configured to emit light in a predetermined pattern that indicates the inactivation area to be illuminated.
  • the second light source 1904 may illuminate a round or rectilinear area that shows where the germicidal light will be illuminated.
  • the second light source may be further collimated and/or shaped to project light in a shape indicating a center of the inactivation area, such as an X-shape or cross shape.
  • the second light source 1904 may be an array of LEDs arranged in a predetermined pattern to project an aiming pattern. It will be further understood that an illumination area of the first light may be limited to be substantially within the inactivation area. With this system, the user can use the second light as an aiming guide to determine where the first light will be illuminated.
  • the first light and the second light may have a spectrum having a full width at half maximum of approximately 10 nm or less.
  • the second light may have a spectrum having a peak wavelength in the visible light spectrum. Further, the second light may have a spectrum having a peak wavelength in a range of 400 nm to 410 nm or in a range of 450 nm to 470 nm.
  • Figure 32 shows at least another embodiment in which a system 2000 may include three light sources.
  • a first light source emits 2002 first light having a spectrum with a peak wavelength in a range of 185 nm to 400 nm.
  • the first light source may emit light having a peak wavelength in a range of 240 nm to 280 nm.
  • a second light source 2004 emits second light having a spectrum with a peak wavelength within the visible light spectrum. Similar to the embodiment of Figure 31, the second light source may be configured may be configured to emit light in a predetermined pattern that indicates the inactivation area to be illuminated as an aiming guide.
  • a third light source 2006 may emit third light having a spectrum with a peak wavelength in a range of 400 nm to 500 nm, a range of 400 nm to 410 nm, or a range of 450 nm to 470 nm.
  • An illumination area of the first light and the third light may be limited to be substantially within the desired inactivation area IA.
  • the system of Figure 31 further includes control electronics 2008 configured to control a first power state of the first light source 2002, a second power state of the second light source 2004, and a third power state of the third light source 2006, and the first, second, and third power states may be independently controlled.
  • a user can have the benefits of two different mechanisms of pathogen inactivation (i.e., the UV first light and the germicidal blue third light), while using the second light as a convenient visual guide for aiming the first light and the third light.
  • the first light source 1502 may emit light having a peak wavelength in a range of 300 nm to 400 nm (i.e., therapeutic UV light) or may emit light having a peak wavelength of approximately 405 nm (i.e., therapeutic blue light).
  • the second light source 1504 may emit light having a peak wavelength in a range of 185 nm to 300 nm (germicidal UV light) or in a range of 400 nm to 500 nm (germicidal blue light).
  • the treatment site could be simultaneously provided with pathogen inactivation to reduce the risk of infections during the treatment.
  • a remote terminal may be used to control the pathogen inactivation system.
  • the remote terminal may be used with a non-transitory computer readable medium that includes computer readable instructions that, when executed by the remote terminal, cause the system to perform the methods illustrated in Figures 28 through 30.
  • the computer readable storage medium can be a tangible device that can retain and store instructions for use by an instruction execution device.
  • the computer readable storage medium may be, for example, but is not limited to, an electronic storage device, a magnetic storage device, an optical storage device, an electromagnetic storage device, a semiconductor storage device, or any suitable combination of the foregoing.
  • a non-exhaustive list of more specific examples of the computer readable storage medium includes the following: a portable computer diskette, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or Flash memory), a static random access memory (SRAM), a portable compact disc read-only memory (CD- ROM), a digital versatile disk (DVD), a memory stick, a floppy disk, a mechanically encoded device such as punch-cards or raised structures in a groove having instructions recorded thereon, and any suitable combination of the foregoing.
  • RAM random access memory
  • ROM read-only memory
  • EPROM or Flash memory erasable programmable read-only memory
  • SRAM static random access memory
  • CD- ROM compact disc read-only memory
  • DVD digital versatile disk
  • memory stick a floppy disk
  • a mechanically encoded device such as punch-cards or raised structures in a groove having instructions recorded thereon
  • a computer readable storage medium is not to be construed as being transitory signals per se, such as radio waves or other freely propagating electromagnetic waves, electromagnetic waves propagating through a waveguide or other transmission media (e.g., light pulses passing through a fiberoptic cable), or electrical signals transmitted through a wire.

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

Un système d'inactivation de pathogènes sur une surface peut comprendre une première source de lumière qui émet une première lumière ayant une longueur d'onde de pic dans une plage de 100 nm à 500 nm; une seconde source de lumière qui émet une seconde lumière qui est la lumière visible; une électronique de commande configurée pour commander un premier état de puissance de la première source de lumière et un second état de puissance de la seconde source de lumière. Le premier état de puissance et le second état de puissance peuvent être commandés indépendamment. Le système peut être configuré de telle sorte qu'une zone d'illumination de la première lumière et de la seconde lumière est limitée à la zone d'inactivation.
PCT/US2016/064352 2016-12-01 2016-12-01 Système et procédé d'inactivation de pathogènes à l'aide de lumière visible et/ou de lumière uv WO2018101943A1 (fr)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10953120B1 (en) 2020-08-03 2021-03-23 Sterilumen, Inc. System for neutralizing pathogens on tactile surfaces
WO2023009040A1 (fr) * 2021-07-27 2023-02-02 Alnassar Abdulaziz Dispositif chirurgical automatique de désinfection pour les mains et procédé d'utilisation
US11998667B2 (en) 2020-07-14 2024-06-04 Energy Harness Corporation Air purification device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100246169A1 (en) * 2007-10-31 2010-09-30 John Anderson Lighting Device
US8142713B2 (en) * 2005-10-26 2012-03-27 Germgard Lighting, Llc Hand sanitizer/sterilizer
US20150062893A1 (en) * 2013-08-30 2015-03-05 American Air & Water, Inc. Ultraviolet disinfection lighting system
US20160015840A1 (en) * 2014-07-16 2016-01-21 LiteProducts LLC Device and method for inactivating pathogens using visible light
WO2016019029A1 (fr) * 2014-07-31 2016-02-04 Vital Vio, Inc. Luminaire de désinfection

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8142713B2 (en) * 2005-10-26 2012-03-27 Germgard Lighting, Llc Hand sanitizer/sterilizer
US20100246169A1 (en) * 2007-10-31 2010-09-30 John Anderson Lighting Device
US20150062893A1 (en) * 2013-08-30 2015-03-05 American Air & Water, Inc. Ultraviolet disinfection lighting system
US20160015840A1 (en) * 2014-07-16 2016-01-21 LiteProducts LLC Device and method for inactivating pathogens using visible light
WO2016019029A1 (fr) * 2014-07-31 2016-02-04 Vital Vio, Inc. Luminaire de désinfection

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11998667B2 (en) 2020-07-14 2024-06-04 Energy Harness Corporation Air purification device
US10953120B1 (en) 2020-08-03 2021-03-23 Sterilumen, Inc. System for neutralizing pathogens on tactile surfaces
WO2023009040A1 (fr) * 2021-07-27 2023-02-02 Alnassar Abdulaziz Dispositif chirurgical automatique de désinfection pour les mains et procédé d'utilisation

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