WO2018080072A3 - 신규한 매크로라이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 말라리아의 예방 또는 치료용 약학적 조성물 - Google Patents

신규한 매크로라이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 말라리아의 예방 또는 치료용 약학적 조성물 Download PDF

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Publication number
WO2018080072A3
WO2018080072A3 PCT/KR2017/011396 KR2017011396W WO2018080072A3 WO 2018080072 A3 WO2018080072 A3 WO 2018080072A3 KR 2017011396 W KR2017011396 W KR 2017011396W WO 2018080072 A3 WO2018080072 A3 WO 2018080072A3
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WIPO (PCT)
Prior art keywords
based compound
preventing
pharmaceutical composition
active ingredient
same
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Application number
PCT/KR2017/011396
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English (en)
French (fr)
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WO2018080072A2 (ko
Inventor
안종석
장재혁
고성균
류인자
손상근
김보연
성낙균
이경호
홍영수
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한국생명공학연구원
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Priority claimed from KR1020170128509A external-priority patent/KR101987853B1/ko
Application filed by 한국생명공학연구원 filed Critical 한국생명공학연구원
Publication of WO2018080072A2 publication Critical patent/WO2018080072A2/ko
Publication of WO2018080072A3 publication Critical patent/WO2018080072A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 신규한 매크로라이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 말라리아의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 따른 화학식 1로 표시되는 매크로라이드계 화합물은 플라스모듐 속(Plasmodium sp.) 원충에 대하여 항원충 활성을 효과적으로 나타내어 말라리아의 예방 또는 치료에 유용하게 사용될 수 있는 효과가 있다.
PCT/KR2017/011396 2016-10-27 2017-10-16 신규한 매크로라이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 말라리아의 예방 또는 치료용 약학적 조성물 WO2018080072A2 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20160140898 2016-10-27
KR10-2016-0140898 2016-10-27
KR1020170128509A KR101987853B1 (ko) 2016-10-27 2017-10-02 신규한 매크로라이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 말라리아의 예방 또는 치료용 약학적 조성물
KR10-2017-0128509 2017-10-02

Publications (2)

Publication Number Publication Date
WO2018080072A2 WO2018080072A2 (ko) 2018-05-03
WO2018080072A3 true WO2018080072A3 (ko) 2018-08-09

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2017/011396 WO2018080072A2 (ko) 2016-10-27 2017-10-16 신규한 매크로라이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 말라리아의 예방 또는 치료용 약학적 조성물

Country Status (1)

Country Link
WO (1) WO2018080072A2 (ko)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000026224A2 (en) * 1998-11-03 2000-05-11 Pfizer Products Inc. Novel macrolide antibiotics
WO2007023370A1 (en) * 2005-08-24 2007-03-01 University Of Stellenbosch Compositions and methods for treating malaria
WO2016033023A2 (en) * 2014-08-25 2016-03-03 The Johns Hopkins University Macrolide compounds and their use in liver stage malaria and related disease

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000026224A2 (en) * 1998-11-03 2000-05-11 Pfizer Products Inc. Novel macrolide antibiotics
WO2007023370A1 (en) * 2005-08-24 2007-03-01 University Of Stellenbosch Compositions and methods for treating malaria
WO2016033023A2 (en) * 2014-08-25 2016-03-03 The Johns Hopkins University Macrolide compounds and their use in liver stage malaria and related disease

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GOODMAN, C. D.: "Chemobiosynthesis of New Antimalarial Macrolides", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 57, no. 2, February 2013 (2013-02-01), pages 907 - 913, XP055537515 *
KIM, G. S.: "P29 A Novel Glycosylated Macrolide from a Rare Actinomycete, Catenulispora sp. 13F217", NATURAL PRODUCT DISCOVERY & DEVELOPMENT IN THE POST GENOMIC ERA, 11 January 2015 (2015-01-11), XP055537508 *
OTOGURO, K.: "In vitro and in vivo antimalarial activities of a non- glycosidic 18-membered macrolide antibiotic, borrelidin, against drug- resistant strains of Plasmodia", THE JOURNAL OF ANTIBIOTICS, vol. 56, no. 8, August 2003 (2003-08-01), pages 727 - 729, XP055537516 *
WILLIAMS, P. G.: "Arenicolides A-C, 26-Membered Ring Macrolides from the Marine Actinomycete Salinispora arenicola", J. ORG. CHEM., vol. 72, no. 14, 6 July 2007 (2007-07-06), pages 5025 - 5034, XP055537512 *

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