WO2018070711A3 - 히알루론산 나노입자를 함유하는 염증질환 및 대사질환의 예방 또는 치료용 약학 조성물 - Google Patents

히알루론산 나노입자를 함유하는 염증질환 및 대사질환의 예방 또는 치료용 약학 조성물 Download PDF

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WO2018070711A3
WO2018070711A3 PCT/KR2017/010824 KR2017010824W WO2018070711A3 WO 2018070711 A3 WO2018070711 A3 WO 2018070711A3 KR 2017010824 W KR2017010824 W KR 2017010824W WO 2018070711 A3 WO2018070711 A3 WO 2018070711A3
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WIPO (PCT)
Prior art keywords
hyaluronic acid
preventing
pharmaceutical composition
reducing
disease
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PCT/KR2017/010824
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English (en)
French (fr)
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WO2018070711A2 (ko
Inventor
김욱
한화승
박재형
노준기
윤주환
Original Assignee
아주대학교산학렵력단
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Priority to US16/340,897 priority Critical patent/US10806800B2/en
Publication of WO2018070711A2 publication Critical patent/WO2018070711A2/ko
Publication of WO2018070711A3 publication Critical patent/WO2018070711A3/ko

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Abstract

본 발명은 히알루론산 나노입자를 함유하는 염증질환 및 대사질환의 예방 또는 치료용 약학 조성물에 관한 것으로, 보다 상세하게는 수용액 상태에서 히알루론산과 5β-콜란산 또는 폴리카프로락톤이 자기조립(self-assembly)를 통해 히알루론산의 소수성 부분(hydrophobic moiety)에 결합되어 형성된 히알루론산 나노입자를 함유하는 염증질환 및 대사질환의 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명에 따른 히알루론산 나노입자를 함유하는 염증질환 또는 대사질환의 예방 또는 치료용 약학 조성물은, 체중을 감소시키고, 식이량을 저하시켰으며, GTT(Glucose Tolerance Test) 결과 혈당을 감소시키는 효과가 있으며, 인슐린 저항성, 염증 유발인자들(NF-κB, IL-1β, CD44, TNF-α, NLRP3 inflammasome 등) 및 대식세포 조직침윤을 저하시키는 효과뿐만 아니라 관절염 증상완화 및 유별율 감소효과가 있으므로 염증질환 및 대사질환의 예방 또는 치료용 약학 조성물로 유용하게 사용될 수 있다.
PCT/KR2017/010824 2016-10-11 2017-09-28 히알루론산 나노입자를 함유하는 염증질환 및 대사질환의 예방 또는 치료용 약학 조성물 WO2018070711A2 (ko)

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KR102187681B1 (ko) * 2018-10-01 2020-12-07 아주대학교산학협력단 히알루론산 나노입자를 함유하는 섬유증의 예방 또는 치료용 약학 조성물
KR102441798B1 (ko) * 2021-07-15 2022-09-08 아주대학교산학협력단 히알루론산 복합체를 포함하는 피부 질환 예방 또는 치료용 약학 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110032561A (ko) * 2009-09-23 2011-03-30 포항공과대학교 산학협력단 약물 전달체의 표적 특이성 조절 방법, 표적 특이적 약물 전달체, 및 표적-비특이적 약효 장기 지속성 약물 전달체
WO2016011436A1 (en) * 2014-07-18 2016-01-21 Wake Forest University Hyaluronic acid-based nanoparticles as biosensors for imaging-guided surgery and drug delivery vehicles and methods associated therewith

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110032561A (ko) * 2009-09-23 2011-03-30 포항공과대학교 산학협력단 약물 전달체의 표적 특이성 조절 방법, 표적 특이적 약물 전달체, 및 표적-비특이적 약효 장기 지속성 약물 전달체
WO2016011436A1 (en) * 2014-07-18 2016-01-21 Wake Forest University Hyaluronic acid-based nanoparticles as biosensors for imaging-guided surgery and drug delivery vehicles and methods associated therewith

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHOI, K. Y. ET AL.: "Hyaluronic Acid-based Nanocarriers for Intracellular Targeting: Interfacial Interactions with Proteins in Cancer", COLLOIDS AND SURFACES B: BIOINTERFACES, vol. 99, 2012, pages 82 - 94, XP028928707 *
CHOI, K. Y. ET AL.: "Self-assembled Hyaluronic Acid Nanoparticles as a Potential Drug Carrier for Cancer Therapy: Synthesis. Characterization, and in Vivo Biodistribution", JOURNAL OF MATERIALS CHEMISTRY, vol. 19, no. 24, 15 May 2009 (2009-05-15), pages 4102 - 4107, XP055509102 *
LEE, G. Y. ET AL.: "Hyaluronic Acid Nanoparticles for Active Targeting Atherosclerosis", BIOMATERIALS, vol. 53, 2015, pages 341 - 348, XP055509099, DOI: doi:10.1016/j.biomaterials.2015.02.089 *

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US20190231898A1 (en) 2019-08-01
US10806800B2 (en) 2020-10-20
KR101905863B1 (ko) 2018-10-08
WO2018070711A2 (ko) 2018-04-19

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