WO2018058911A1 - 一种应用于人体开放管腔道的oct探头 - Google Patents

一种应用于人体开放管腔道的oct探头 Download PDF

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WO2018058911A1
WO2018058911A1 PCT/CN2017/076894 CN2017076894W WO2018058911A1 WO 2018058911 A1 WO2018058911 A1 WO 2018058911A1 CN 2017076894 W CN2017076894 W CN 2017076894W WO 2018058911 A1 WO2018058911 A1 WO 2018058911A1
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probe
oct
metal coil
tip
protector
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PCT/CN2017/076894
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English (en)
French (fr)
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蔡志岗
孔冠岳
高峻
马鸿键
陈梓艺
李佼洋
李百灵
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广州永士达医疗科技有限责任公司
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Priority to EP17854371.6A priority Critical patent/EP3520683A4/en
Publication of WO2018058911A1 publication Critical patent/WO2018058911A1/zh
Priority to US16/362,613 priority patent/US11219369B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
    • A61B2562/168—Fluid filled sensor housings
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/0018—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 with means for preventing ghost images

Definitions

  • the invention belongs to the technical field of medical instruments, and in particular relates to an OCT probe applied to an open tube channel of a human body.
  • OCT optical coherence tomography
  • OCT tomography has higher resolution than X-ray imaging, ultrasound imaging and magnetic resonance imaging.
  • the current OCT tomography technology can achieve 10 ⁇ m resolution, which is higher than X-ray and MRI. Two orders of magnitude. High-resolution, non-destructive testing and other advantages make OCT tomography technology widely used in fields such as ophthalmology, dermatology, dentistry and process product testing, and have achieved satisfactory results.
  • the current OCT tomography uses near-infrared light (such as 1300nm) as the detection source, while near-infrared light does not penetrate the red blood cells in the blood vessels well, so it is in the cardiovascular.
  • near-infrared light such as 1300nm
  • This method of detection is risky and can easily cause myocardial ischemia in patients, and the operation is complicated, which has high operational requirements for the operator.
  • OCT technology to areas such as angiography and intraluminal tissue (such as lung), improving the imaging quality of OCT tomography is the key.
  • the patent CN201520036955.2 adopts a method of completely matching the inner wall of the protective sleeve with the front end of the probe body.
  • the transmission sleeve has a transmission relationship with the probe body.
  • the OCT probe mainly uses a circumferential circular scanning method during biopsy, which requires that the OCT protection sleeve in contact with human tissue cannot perform circumferential circular motion. Therefore, it is of great significance to find a method that can effectively improve the quality of OCT tomography imaging.
  • an object of the present invention is to provide an OCT probe applied to an open lumen of a human body, which can solve the problem of air gap between the probe body and the external probe guard during scanning imaging. A defect that causes the image to be unclear.
  • An OCT probe applied to an open tube channel of a human body comprising a probe protector, a probe body, an oily liquid, a metal coil, a probe guard tip and a light guiding optical fiber, wherein the probe body and The metal coil is matched and mounted, and the metal coil is mounted on the rear end of the probe body, the light guiding fiber is fixed inside the probe body, the probe tip is sleeved on the probe body, and the probe guard is sleeved on the probe guard And the metal coil, and the oily liquid is filled between the probe tip and the metal coil and the probe protector.
  • a fixing member is further included for fixing the probe body to the probe tip. It can further solve the technical problem of fixing the probe tip and the probe body.
  • the probe guard is a medical round nylon flexible tube. It can further solve the technical problem of selecting the material of the probe guard.
  • the front end of the probe guard is hemispherical, and the outer diameter of the probe guard is less than or equal to 3 mm. It can further solve the technical problem of the selection of the probe guard.
  • the fixing member is a medical plastic fixing member or a medical stainless steel fixing member. It further solves the technical problem of the selection of the material of the fixture.
  • the probe tip is a medical stainless steel probe guard. It further solves the technical problem of the selection of the material of the probe tip.
  • the oily liquid has the same refractive index as the probe guard. It further solves the technical problem of light guiding offset.
  • the method further includes engaging a stator for fixing the metal coil to the light guiding optical fiber. It can further solve the technical problem of fixing the metal coil and the light guiding fiber.
  • the invention effectively fills up the OCT endoscopic scanning imaging technology in scanning the open body lumen of the human body through the OCT external probe guard and the probe body, because the probe body and the external probe guard exist between Air gaps cause images not Clear defects that optimize imaging.
  • FIG. 1 is a schematic view showing the structure of an OCT probe applied to an open lumen of a human body according to the present invention.
  • the embodiment provides an OCT probe applied to an open tube channel of a human body, including a probe protector 1 , a probe body 2 , an oily liquid 3 , a metal coil 4 , a fixing member 7 , a connecting stator 401 ,
  • the probe body 5 and the light guiding fiber 6, the probe body 2 is matched with the metal coil 4, and the metal coil 4 is mounted on the rear end of the probe body 2.
  • the light guiding fiber 6 is fixed inside the probe body 2, and the probe body 2
  • the fragile optical fiber can be effectively protected, and the engaging stator 401 is used to fix the metal coil 4 and the light guiding fiber 6.
  • the torque transmitted by the metal coil 4 through the connecting stator 401 can be rotated and translated synchronously with the light guiding fiber 6, so that the probe is more smoothly and smoothly used.
  • the human open tube channel mentioned in this embodiment may include the respiratory tract, the reproductive tract, the anorectal tract, the esophagus, the ear canal, the urethra, the uterine cavity, the stomach cavity, the oral cavity, etc., which are merely illustrative examples, not List all open channels of the human body.
  • the probe guard 5 is sleeved on the probe body 2, and the probe guard 5 is medically Stainless steel probe guard tip.
  • the fixing member 7 is used to fix the probe body 2 to the probe tip 5 .
  • the fixing member 7 is a medical plastic fixing member or a medical stainless steel fixing member.
  • the probe protector 1 is sleeved on the probe tip 5 and the metal coil 4, and the probe protector 1 is a medical round nylon flexible tube.
  • the front end of the probe protector 1 is hemispherical, and the outer diameter of the probe protector 1 is less than or equal to 3 mm, and the oily liquid 3 is filled between the probe tip 5 and the metal coil 4 and the probe protector 1.
  • the oily liquid 3 has the same refractive index as the probe protector 1.
  • the light When they have the same or similar refractive index, the light will not be deflected due to the difference in refractive index when it exits, resulting in an unclear image, unlike when there is no oily liquid 3, it will be produced.
  • the image is unclear, and the oily liquid has a colorless, transparent, non-toxic, low-viscosity property, which further ensures the clarity of the transmitted image.

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Abstract

一种应用于人体开放管腔道的OCT探头，包括探头护件（1）、探头本体（2）、油性液体（3）、金属线圈（4）、探头护梢（5）和导光光纤（6）。探头本体（2）与金属线圈（4）匹配安装，且金属线圈（4）安装于探头本体（2）的后端，导光光纤（6）固定于探头本体（2）内部，探头护梢（5）套接于探头本体（2）上，探头护件（1）套接于探头护梢（5）及金属线圈（4）上，且油性液体（3）填充于探头护梢（5）及金属线圈（4）与探头护件（1）之间。通过在OCT外部探头护件（1）与探头本体（2）之间填充油性液体（3），有效弥补了OCT内窥扫描成像技术在人体复杂人体开放管腔道进行扫描时，因探头本体（2）与外部探头护件（1）之间存在空气缝隙而造成图像不清晰的缺陷，优化了成像效果。

Description

一种应用于人体开放管腔道的OCT探头 技术领域
本发明属于医疗器械技术领域，尤其涉及一种应用于人体开放管腔道的OCT探头。
背景技术
光学相干层析技术(Optical coherence Tomography,OCT)是近十年迅速发展的一种高分辨率成像技术，该技术是基于低相干光干涉原理，并与共焦显微技术相结合，检测生物组织不同深度层对入射弱相干光的后向散射波回波时间延迟及回波强度信号，通过扫描得到样品二维或者三维的高分辨率微观组织结构，从而获得被测样品在体无损的断层层析图像。OCT成像技术无需添加任何显影剂，没有电离效应和荧光效应，比传统的影像技术安全性更高，被称为“光学活检”。
相比X射线成像、超声成像及核磁共振成像技术，OCT断层扫描成像技术有着更高的分辨率，目前普遍的OCT断层扫描成像技术能达到10μm级别分辨率，比X射线及核磁共振成像技术高出两个量级。高分辨率，无损检测等优点使得OCT断层扫描成像技术在诸如眼科、皮肤科、牙科以及工艺制品检测等领域得到广泛的应用，并取得了令人满意的效果。
现行的OCT断层扫描技术都采用近红外光(如1300nm)作为探测光源，而近红外光并不能很好的穿透血管中的红细胞，所以在心血管 领域应用OCT技术时必须采取短时间阻断血流或局部冲洗血管等方法来排除血管中的血液，然后进行扫描成像。这种探测方法风险较大，容易造成患者心肌缺血，而且操作复杂，对操作者有很高的操作要求。要将OCT技术广泛应用到血管造影、腔内组织(如肺部)检查等领域，提高OCT断层扫描成像技术的成像质量是关键。
目前用于血管探测的OCT探头，存在扫描探头与外部保护套之间有空气缝隙的缺陷。空气缝隙的存在使得从探头出射的光斑容易产生畸变，变成椭圆光斑，影响光束的汇聚效果，从而导致成像质量的下降。针对该问题，专利CN201520036955.2采取一种保护套管内壁与探头本体前端完全匹配的方法，虽解决了空气间隙的问题，但由于完全匹配，此时保护套管与探头本体之间具有传动关系，而OCT探头在活检时主要采用周向环形扫描的方式，这要求与人体组织接触的OCT保护套管不能进行周向环形运动。因此，寻找一种能有效提高OCT断层扫描成像质量的方法具有重要意义。
发明内容
为了克服现有技术的不足，本发明的目的在于提供一种应用于人体开放管腔道的OCT探头，其能解决在扫描成像的时候，因探头本体与外部探头护件之间存在空气间隙而造成图像不清晰的缺陷。
本发明的目的采用以下技术方案实现：
一种应用于人体开放管腔道的OCT探头，包括探头护件、探头本体、油性液体、金属线圈、探头护梢和导光光纤，所述探头本体与 金属线圈匹配安装，且金属线圈安装于探头本体的后端，所述导光光纤固定于探头本体内部，所述探头护梢套接于探头本体上，所述探头护件套接于探头护梢及金属线圈上，且所述油性液体填充于探头护梢及金属线圈与探头护件之间。
优选地，还包括固定件，所述固定件用于将探头本体与探头护梢固定。其能进一步解决探头护梢与探头本体的固定的技术问题。
优选地，所述探头护件为医用圆头尼龙弹性管。其能进一步解决探头护件的材料的选取的技术问题。
优选地，所述探头护件的前端为半球形，且探头护件外径小于等于3mm。其能进一步解决探头护件的选取的技术问题。
优选地，所述固定件为医用塑料固定件或者医用不锈钢固定件。其进一步解决了固定件的材料的选取的技术问题。
优选地，所述探头护梢为医用不锈钢探头护梢。其进一步解决了探头护梢的材料的选取的技术问题。
优选地，所述油性液体与探头护件有相同的折射率。其进一步解决了导光偏移的技术问题。
优选地，还包括衔接定子，所述衔接定子用于将金属线圈与导光光纤固定。其能进一步解决金属线圈与导光光纤的固定的技术问题。
相比现有技术，本发明的有益效果在于：
本发明通过在OCT外部探头护件与探头本体之间填充油性液体，有效弥补了OCT内窥扫描成像技术在人体复杂人体开放管腔道进行扫描时，因探头本体与外部探头护件之间存在空气缝隙而造成图像不 清晰的缺陷，优化了成像效果。
附图说明
图1为本发明的应用于人体开放管腔道的OCT探头的结构示意图。
附图标记：1、探头护件；2、探头本体；3、油性液体；4、金属线圈；401、衔接定子；5、探头护梢；6、导光光纤；7、固定件。
具体实施方式
下面，结合附图以及具体实施方式，对本发明做进一步描述：
如图1所示，本实施例提供了一种应用于人体开放管腔道的OCT探头，包括探头护件1、探头本体2、油性液体3、金属线圈4、固定件7、衔接定子401、探头护梢5和导光光纤6，所述探头本体2与金属线圈4匹配安装，且金属线圈4安装于探头本体2的后端，所述导光光纤6固定于探头本体2内部，探头本体2能够有效的保护脆弱的光纤，所述衔接定子401用于固定金属线圈4与导光光纤6。其可通过衔接定子401传递金属线圈4的扭矩与导光光纤6同步转动平移，使得探头使用起来更加的平稳顺畅。本实施例中所提及的的人体开放管腔道可以包括呼吸道、生殖道、肛肠道、食道、耳道、尿道、子宫腔、胃腔、口腔等，这些仅仅是作为示例性说明，并非罗列出所有的人体开放管腔道。
所述探头护梢5套接于探头本体2上，所述探头护梢5为医用不 锈钢探头护梢。所述固定件7用于将探头本体2与探头护梢5固定。所述固定件7为医用塑料固定件或者医用不锈钢固定件。所述探头护件1套接于探头护梢5及金属线圈4上，所述探头护件1为医用圆头尼龙弹性管。所述探头护件1的前端为半球形，且探头护件1的外径小于等于3mm，所述油性液体3填充于探头护梢5及金属线圈4与探头护件1之间。所述油性液体3与探头护件1有相同的折射率。当其具有相同或者相近的折射率的时候，光线在出射的时候不会因为折射率不同从而导致光线的偏移，从而造成图像不清晰的情况，而不像没有油性液体3时，会使得产生的图像不清楚，并且该油性液体具有无色透明、无毒、低粘稠度的特性，这样能够进一步保证传输图像的清晰度。
对本领域的技术人员来说，可根据以上描述的技术方案以及构思，做出其它各种相应的改变以及形变，而所有的这些改变以及形变都应该属于本发明权利要求的保护范围之内。

Claims (8)

  1. 一种应用于人体开放管腔道的OCT探头，其特征在于，包括探头护件、探头本体、油性液体、金属线圈、探头护梢和导光光纤，所述探头本体与金属线圈配合安装，且金属线圈安装于探头本体的后端，所述导光光纤穿插安装于探头本体内部，所述探头护梢套接于探头本体上，所述探头护件套接于探头护梢及金属线圈上，且所述油性液体填充于探头护梢与探头护件之间和金属线圈与探头护件之间。
  2. 如权利要求1所述的应用于人体开放管腔道的OCT探头，其特征在于，还包括固定件，所述固定件用于将探头本体与探头护梢固定。
  3. 如权利要求2所述的应用于人体开放管腔道的OCT探头，其特征在于，所述固定件为医用塑料固定件或者医用不锈钢固定件。
  4. 如权利要求1所述的应用于人体开放管腔道的OCT探头，其特征在于，所述探头护件为医用圆头尼龙弹性管。
  5. 如权利要求1所述的应用于人体开放管腔道的OCT探头，其特征在于，所述探头护件的前端为半球形，且探头护件外径小于等于3mm。
  6. 如权利要求1所述的应用于人体开放管腔道的OCT探头，其特征在于，所述探头护梢为医用不锈钢探头护梢。
  7. 如权利要求1所述的应用于人体开放管腔道的OCT探头，其特征在于，所述油性液体与探头护件有相同的折射率。
  8. 如权利要求1所述的应用于人体开放管腔道的OCT探头，其特征在于，还包括衔接定子，所述衔接定子用于将金属线圈与导光光 纤固定。
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US11219369B2 (en) 2022-01-11

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