WO2018051294A3 - Non—saponifiable compounds of natural lipids for use in the treatment of cardiac pathologies - Google Patents

Non—saponifiable compounds of natural lipids for use in the treatment of cardiac pathologies Download PDF

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Publication number
WO2018051294A3
WO2018051294A3 PCT/IB2017/055621 IB2017055621W WO2018051294A3 WO 2018051294 A3 WO2018051294 A3 WO 2018051294A3 IB 2017055621 W IB2017055621 W IB 2017055621W WO 2018051294 A3 WO2018051294 A3 WO 2018051294A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
chronic
saponifiable
cardiac
natural
Prior art date
Application number
PCT/IB2017/055621
Other languages
French (fr)
Other versions
WO2018051294A2 (en
Inventor
Chiara De Gregorio
Original Assignee
Codex V Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codex V Srl filed Critical Codex V Srl
Publication of WO2018051294A2 publication Critical patent/WO2018051294A2/en
Publication of WO2018051294A3 publication Critical patent/WO2018051294A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Abstract

The present invention relates to the use of non-saponifiable moieties obtained from natural, plant and/or animal lipids, for the treatment of cardiac diseases caused by the permanent (or chronic) alteration (or imbalance) of the normal physiological equilibrium of the steroidal balance in a patient suffering from this chronic condition. In particular, the invention relates to a pharmaceutical composition of said non-saponifiable moieties for use in the treatment of those cardiac disorders, heart failure and/or cardiac arrhythmias and/or myocardial ischemic disease and/or atrioventricular dysfunction or valvulopathies, which are caused by permanent, chronic, pathological alteration of the natural physiological equilibrium of the steroidal balance in a patient suffering from said disease, and of the chronic lesions, either peripheral or not, associated with the same that determine them. Said pharmaceutical composition is particularly adapted for transdermal topical administration.
PCT/IB2017/055621 2016-09-19 2017-09-18 Non—saponifiable compounds of natural lipids for use in the treatment of cardiac pathologies WO2018051294A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102016000093741 2016-09-19
IT102016000093741A IT201600093741A1 (en) 2016-09-19 2016-09-19 UNSAPONIFYABLE OF NATURAL LIPIDS FOR USE IN THE TREATMENT OF CARDIAC DISEASES

Publications (2)

Publication Number Publication Date
WO2018051294A2 WO2018051294A2 (en) 2018-03-22
WO2018051294A3 true WO2018051294A3 (en) 2018-05-03

Family

ID=57909885

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2017/055621 WO2018051294A2 (en) 2016-09-19 2017-09-18 Non—saponifiable compounds of natural lipids for use in the treatment of cardiac pathologies

Country Status (2)

Country Link
IT (1) IT201600093741A1 (en)
WO (1) WO2018051294A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000044470A (en) * 1998-08-04 2000-02-15 Nof Corp Hyperlipemia medicine
US6277431B1 (en) * 1998-10-14 2001-08-21 Redeem, Inc. Anticholesterolemic edible oil
US20070116812A1 (en) * 2005-11-18 2007-05-24 Philippe Msika Process for producing refined avacado oil rich in triglycerides, and oil obtainable by said process
US20070243233A1 (en) * 2006-04-18 2007-10-18 Naturi Llc Bioactive-rich concentrates and nutritive and therapeutic products containing same
US20120225941A1 (en) * 2011-03-03 2012-09-06 Tersus Pharmaceuticals, LLC COMPOSITIONS AND METHODS COMPRISING C16:1n7-PALMITOLEATE
CN102919383A (en) * 2012-11-05 2013-02-13 菏泽瑞璞牡丹产业科技发展有限公司 Blend oil containing peony seed oil and preparation method of blend oil

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000044470A (en) * 1998-08-04 2000-02-15 Nof Corp Hyperlipemia medicine
US6277431B1 (en) * 1998-10-14 2001-08-21 Redeem, Inc. Anticholesterolemic edible oil
US20070116812A1 (en) * 2005-11-18 2007-05-24 Philippe Msika Process for producing refined avacado oil rich in triglycerides, and oil obtainable by said process
US20070243233A1 (en) * 2006-04-18 2007-10-18 Naturi Llc Bioactive-rich concentrates and nutritive and therapeutic products containing same
US20120225941A1 (en) * 2011-03-03 2012-09-06 Tersus Pharmaceuticals, LLC COMPOSITIONS AND METHODS COMPRISING C16:1n7-PALMITOLEATE
CN102919383A (en) * 2012-11-05 2013-02-13 菏泽瑞璞牡丹产业科技发展有限公司 Blend oil containing peony seed oil and preparation method of blend oil

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 200019, Derwent World Patents Index; AN 2000-217926, XP002768785 *
DATABASE WPI Week 201351, Derwent World Patents Index; AN 2013-H79847, XP002768784 *

Also Published As

Publication number Publication date
WO2018051294A2 (en) 2018-03-22
IT201600093741A1 (en) 2018-03-19

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