WO2018042435A1 - A pest control composition and method thereof - Google Patents

A pest control composition and method thereof Download PDF

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Publication number
WO2018042435A1
WO2018042435A1 PCT/IL2017/050973 IL2017050973W WO2018042435A1 WO 2018042435 A1 WO2018042435 A1 WO 2018042435A1 IL 2017050973 W IL2017050973 W IL 2017050973W WO 2018042435 A1 WO2018042435 A1 WO 2018042435A1
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WIPO (PCT)
Prior art keywords
composition
pest
complex
glycerin
compound
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PCT/IL2017/050973
Other languages
French (fr)
Inventor
Raziel KUBASHI LEVI
Martin WIRTSCHAFTER
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Nontoxico Ltd
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Publication of WO2018042435A1 publication Critical patent/WO2018042435A1/en

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing acyclic or cycloaliphatic radicals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/14—Boron; Compounds thereof

Definitions

  • the present invention relates to novel compositions and methods for pest control. More particularly, the present invention relates to a coating composition which targets the respiratory and sensory system of the pest.
  • compositions have been proposed for pest control and pesticide.
  • US patent app. No. 2014039013 provides chemical modulators of pest olfactory receptors.
  • compounds and compositions are provided that can inhibit host targeting functions in pests. Method of employing such agents, and articles incorporating the same, are also presented.
  • PCT app. WO2006044060 relates to protective coated fruits and vegetables, and methods for the treatment of plants that reduces the incidence of pest and sunburn damage, and other stress-induced disorders of horticultural crops ⁇
  • US patent No. 5221535 provides a process of preparing an emulsion of a solubilized compound, the compound being soluble in a physiologically acceptable aqueous or nonaqueous solvent, said process comprising: (1) adding a complexing agent to at least one said solvent containing at least one said compound, the agent being capable of forming a compound: agent complex; (b) adding an emulsifier to the solvent containing the compound and the complexing agent; and (c) forming an emulsion.
  • the invention also provides a process of preparing a dispersion of a compound which is insoluble in a physiologically acceptable aqueous or nonaqueous solvent but only soluble in a physiologically unacceptable solvent, said process comprising: (a) adding said compound to at least one physiologically acceptable solvent; (b) adding a complexing agent to the compound plus solvent of (a); (c) further adding an emulsifier to the compound plus solvent plus complexing agent of (b); (d) forming a dispersion of said compound in said physiologically acceptable solvent
  • US patent No.5188837 presents a microsuspension system and method for its preparation is disclosed.
  • the microsuspension contains lipospheres, which are solid, water-insoluble microparticles that have a layer of a phospholipid embedded on their surface.
  • the core of the liposphere is a solid substance to be delivered, or a substance to be delivered that is dispersed in an inert solid vehicle, such as a wax.
  • a pest control composition comprises a coating composition, wherein said composition comprises a combination of organo-metalloid complex and a phospholipid compound.
  • organo-metalloid complex comprises a mixture of boro-glycerin complex in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
  • a pest control composition comprises a combination of organo-metalloid complex and a phospholipid compound, wherein said organo-metalloid complex is a mixture of citric acid -glycerin in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight. It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein the combination of the boro-glycerin complex and aminopolycarboxylic compound in a predefined ratio, further configured to disrupt spiracle control in said pests, further increasing mortality of said pests.
  • the glycerin is configured to dissolve and to be reacted with the boric acid further configured to form a boro-glycerine complex.
  • the glycerin is configured to dissolve and to be reacted with the citric acid further configured to form a citro-glycerine complex.
  • said phospholipid compound comprises at least one substance selected from the group consisting of Phosphatidic acid (phosphatidate), Phosphatidylethanolamine (cephalin) (PE), Phosphatidylcholine (lecithin) (PC), Phosphatidylserine (PS), Phosphatidylinositol (PI), Phosphatidylinositol phosphate (PIP), Phosphatidylinositol bisphosphate (PIP2) ,Phosphatidylinositol triphosphate (PIP3), Ceramide phosphorylcholine (Sphingomyelin) (SPH), Ceramide phosphorylethanolamine (Sphingomyelin) (Cer-PE) ,Ceramide phosphoryllipid and any combination thereof.
  • Phosphatidic acid phosphatidate
  • Phosphatidylethanolamine cephalin
  • PC Phosphatidyl
  • compositions as mentioned in any of the above,additionally comprising at least one substance selected from the group consisting of detergent, paraffin wax, aromatic oil, phospholipid, alcohol, dextrose monohydrate, inorganic salts selected from a group consisting magnesium sulphate, potassium permanganate calcium chloride, and any mixture thereof.
  • compositions as mentioned in any of the above wherein said compositions have low toxicity. It is also an object of the present invention to provide a composition as mentioned in any of the above, further comprises at least one controlled-release formulation configured to maintain constant concentration of at least one of the ingredients of said compositions, for a specific period of time.
  • aqueous preparation is in the form of a liquid, solution, lotion, mixture, compound, formulation, gel, cream, liquid infusion, spray, suspension, emulsion, emollient preparation, emollient moisturizer and any combination thereof.
  • compositions as mentioned in any of the above, additionally comprising at least one substance selected from the group consisting of about 0.5% detergent, about 15% phospholipid compound, about 7% alcohol, about 1% aromatic oil with concentration of about 2.5% , about 7% paraffin wax, about 2% dextrose monohydrate, about 1% aromatic oil and about 2% inorganic salt selected from a group consisting magnesium sulphate, calcium chloride or potassium permanganate , and any mixture thereof.
  • compositions as mentioned in any of the above, wherein additionally comprising a water solution in a ratio ranging from about 1: 10 to about 1:50, respectively.
  • It is hence one object of the present invention to provide method for controlling pests comprising steps of providing a coating composition, and applying said composition to a location to be so controlled wherein said composition comprises a combination of organo-metalloid complex and a phospholipid compound. It is also an object of the present invention to provide a method as mentioned in any of the above, wherein said composition is aqueous.
  • organo-metalloid complex comprises a mixture of boro- glycerin complex in a range of about 65% by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
  • It is hence one object of the present invention to provide method for controlling pests comprising steps of providing a combination of organo-metalloid complex and a phospholipid compound, wherein said organo-metalloid complex is a mixture of citric acid -glycerin in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
  • said phospholipid compound comprises at least one substance selected from the group consisting of Phosphatidic acid (phosphatidate), Phosphatidylethanolamine (cephalin) (PE), Phosphatidylcholine (lecithin) (PC), Phosphatidylserine (PS), Phosphatidylinositol (PI), Phosphatidylinositol phosphate (PIP), Phosphatidylinositol bisphosphate (PIP2) ,Phosphatidylinositol triphosphate (PIP3), Ceramide phosphorylcholine (Sphingomyelin) (SPH), Ceramide phosphorylethanolamine (Sphingomyelin) (Cer-PE) ,Ceramide phosphoryllipid and any combination thereof.
  • Phosphatidic acid phosphatidate
  • Phosphatidylethanolamine cephalin
  • PC Phosphatidyl
  • aqueous preparation is in the form of a liquid, solution, lotion, mixture, compound, formulation, gel, cream, liquid infusion, spray, suspension, emulsion, emollient preparation, emollient moisturizer and any combination thereof.
  • FIG. la-c presents the: (a) boro-glycerin complex,(b)citric acid , and (c) lecithin of the present invention.
  • FIG. 2 presents the sensor system of a pest
  • FIG. 3 presents the cuticle system of a pest which the composition targets, of the present invention
  • FIG. 4A presents a graph illustrating the effectiveness of the Razox composition of the present invention
  • FIG. 4B presents a graph illustrating the effectiveness of the Razox-CAC composition of the present invention.
  • FIG. 5 presents the cockroach condition after exposure to the Razox composition (a combination of organo-metalloid complex and a phospholipid compound of the present invention) before contact with extraneous water; and
  • FIG.6 presents the pest condition after exposure to the Razox composition of the present invention and contact with water, resulting in ingress of water into the cockroach body and exploding of the cockroach.
  • the essence of the present invention is to provide a composition for controlling pests and killing pests compositions.
  • the pest control composition of the present invention is provided in forms which can be applied directly to plants, trees, orchards, fields, barns, hothouses, glasshouses, nurseries, growing rooms, livestock, pets, poultry and chicken houses, hatcheries and chicken-runs and the like, commonly used in agriculture.
  • the pest control composition of the present invention can be provided in a form or format to be delivered directly on the relevant surfaces of the aforementioned or directly on the pests.
  • the pest control composition of the present invention can be provided in a form or format to be used in habitations, houses, apartments, shops, stroes schools, ships aircraft and the like.
  • the pest control composition of the present invention can be provided in a form or format to be delivered directly on the relevant surfaces of the aforementioned or directly on the pests.
  • the pest-control composition comprises a combination of organo-metalloid complex such as boro-glycerine, compound of boric acid and glycerine (e.g antiseptic material) as illustrated in Figure la; or a combination of organo-metalloid complex such as citro-glycerine ( Figure lb), compound of citric acid and glycerine and a phospholipid compound such as lecithin as illustrated in Figure lc.
  • compositions are directed to inhibiting a wide variety of pests' species, especially agricultural and horticultural pests.
  • FIG. 2 illustrates the sensory and nervous system of the pest.
  • the composition targets and inhibits the functions of the sensors or/and the spiracle of the pest, forming a coating or a barrier around the pest body surface, more particularity blocking the breathing spiracles, sensory hairs and organs of the pest.
  • Spiracles are openings on the thorax of hexapods, including insects.
  • the spiracles open into chitinous tubes called tracheae which then further subdivide until becoming less than 1 mm in diameter tracheoles, forming a network all through the body of the organism, said network is the respiratory system of these organisms.
  • the spiracles are muscular valves in the insect body, and their opening can be controlled, mostly in order to regulate water loss. This mechanism is controlled by the central nervous system but can also react to localized chemical stimuli. Several aquatic insects have similar or alternative closing methods to prevent water from entering the trachea. The timing and duration of spiracle closures can affect the respiratory rates of the organism.
  • the phospholipids of the composition provide a first layer which blocks the respiratory system of the pest and further inhibits the pest nervous system from environmental stimuluses.
  • composition of the present invention targets the spiracles which act as muscular valves in some pests, lead to the internal respiratory system, a densely networked array of tubes called tracheae. This network of transverse and longitudinal tracheae equalizes pressure throughout the system.
  • FIG. 3 illustrates the cuticle system of a pest which the composition of the present invention targets.
  • the composition is formulated as contact pesticides which penetrate the pest cuticle or enter through the spiracles of the respiratory system.
  • composition of the present invention is an aqueous preparation which may be in the form of a liquid, solution, lotion, mixture, compound, formulation, gel, cream, liquid infusion, spray, suspension, emulsion, emollient preparation, emollient moisturizer and any combination thereof.
  • Pest herein refers to a plant or animal detrimental to humans or human concerns (as agriculture or livestock production); alternative meaning includes organisms that cause nuisance and epidemic disease associated with high mortality.
  • a pest is any living organism which is invasive or prolific, detrimental, troublesome, noxious, destructive, a nuisance to either plants or animals, human or human concerns, livestock, human structures, wild ecosystems etc. It is a loosely defined term, often overlapping with the related terms vermin, weed, plant and animal parasites and pathogens. It is possible for an organism to be a pest in one setting but beneficial, domesticated or acceptable in another.
  • Razox composition refers to one combination of organo-metalloid complex and a phospholipid compound. This combination is a mixture of: boro- glycerin complex in a range of about 65% by weight , EDTA in a range of about 0.5% by weight , 0.5% SLS, about 2% Magnesium sulphate, about 15% lecithin, about 7% paraffin wax, about 7% isopropanol, about 2% dextrose monohydrate and about 1% aromatic oil with concentration of about 2.5%.
  • Razox-CAC composition refers to another combination of organo- metalloid complex and a phospholipid compound. This combination is a mixture of citric acid and glycerin complex in a range of about 65% by weight , EDTA in a range of about 0.5% by weight , 0.5% SLS, about 2% potassium permanganate, about 15% lecithin, about 7% paraffin wax, about 7% isopropanol, about 2% dextrose monohydrate, and about 1% aromatic oil with concentration of about 2.5%.
  • the inorganic salts magnesium sulphate, calcium chloride or potassium permanganate can be used interchangeably in the above compositions, Razox composition and Razox-CAC composition.
  • the detergent SLS combined with boro-glycerin enables the adherence of the coating formation to the pest respiratory system. Since the pest body is covered with a hydrophobic fraction there is an improved adsorption of the boro-glycerin around the pest body whilst the lecithin and SLS as a mixture provides a binding substance which allows conjugation between the hydrophobic fraction to the hydrophilic fraction. This results in a higher entropic state which causes non-polar molecules to clump together to reduce the surface area exposed to water and decrease the entropy of the system.
  • the phospholipids e.g. lecithin when mixed with SLS forms micelles in an aqueous environment.
  • the micelles target the cuticle of the pest thereby, forming a coated barrier around the pest body.
  • the Magnesium sulphate salt or Potassium permanganate is a hygroscopic material which enables the boro-glycerin complex comprising boric acid compound to be dissolved and provides an improved pesticide with low toxicity to the environment.
  • the glycerin is used as a solvent medium of the composition for dissolving and to be reacted with the boric acid forming a boro-glycerine complex.
  • the boric acid compound is mixed at 25 °c with about 70 to 80% of glycerin forming boro-glycerine complex
  • the composition has low viscosity resulting from the alcohol compound.
  • a pest control composition comprises a coating composition, wherein said composition comprises a combination of organo-metalloid complex and a phospholipid compound.
  • organo-metalloid complex comprises a mixture of boro-glycerin complex in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
  • a pest control composition comprises a combination of organo-metalloid complex and a phospholipid compound, wherein said organo-metalloid complex is a mixture of citric acid -glycerin in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
  • the glycerin is configured to dissolve and to be reacted with the boric acid further configured to form a boro-glycerine complex.
  • the glycerin is configured to dissolve and to be reacted with the citric acid further configured to form a citro-glycerine complex.
  • said phospholipid compound comprises at least one substance selected from the group consisting of Phosphatidic acid (phosphatidate), Phosphatidylethanolamine (cephalin) (PE), Phosphatidylcholine (lecithin) (PC), Phosphatidylserine (PS), Phosphatidylinositol (PI), Phosphatidylinositol phosphate (PIP), Phosphatidylinositol bisphosphate (PIP2) ,Phosphatidylinositol triphosphate (PIP3), Ceramide phosphorylcholine (Sphingomyelin) (SPH), Ceramide phosphorylethanolamine (Sphingomyelin) (Cer- PE) ,Ceramide phosphoryllipid and any combination thereof.
  • Phosphatidic acid phosphatidate
  • Phosphatidylethanolamine cephalin
  • PC Phosphatidyl
  • composition mentioned above additionally comprising at least one substance selected from the group consisting of detergent, paraffin wax, aromatic oil, phospholipid, alcohol, dextrose monohydrate, inorganic salts selected from a group consisting magnesium sulphate, potassium permanganate calcium chloride, and any mixture thereof.
  • compositions mentioned above wherein said composition dispersed on a pest provides a thin coating layer upon the epicuticle of the pests for inhibition of pest host sensing.
  • composition impairs respiration of the pest, forming a barrier upon at least one selected from the group consisting of the pest body surface, the breathing spiracles, the sensory hairs and organs.
  • composition when layered on said cockroach in vivo and in contact with a substance selected from a group consisting water, moisture, humidity, and any combination thereof, facilitates entry of water via dysfunctional spiracles, into said insect , sufficient to kill said pest.
  • composition mentioned above wherein said compositions have low toxicity.
  • composition mentioned above further comprises at least one controlled-release formulation configured to maintain constant concentration of at least one of the ingredients of said compositions, for a specific period of time.
  • aqueous preparation is in the form of a liquid, solution, lotion, mixture, compound, formulation, gel, cream, liquid infusion, spray, suspension, emulsion, emollient preparation, emollient moisturizer and any combination thereof.
  • composition mentioned above additionally comprising at least one substance selected from the group consisting of about 0.5% detergent, about 15% phospholipid compound, about 7% alcohol, about 1% aromatic oil with concentration of about 2.5% , about 7% paraffin wax, about 2% dextrose monohydrate, about 1% aromatic oil and about 2% inorganic salt selected from a group consisting magnesium sulphate, calcium chloride or potassium permanganate , and any mixture thereof.
  • a dispersing device for delivering an aerosolized spray of composition of claim 1, comprising: a housing having an internal cavity containing said pest control composition; and a control valve for delivering said composition from the cavity to a selected site; wherein the composition of claim 1 comprises said mixture of boro-glycerin complex or said mixture of citric acid -glycerin complex.
  • organo-metalloid complex comprises a mixture of boro-glycerin complex in a range of about 65% by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
  • organo-metalloid complex is a mixture of citric acid -glycerin in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
  • said phospholipid compound comprises at least one substance selected from the group consisting of Phosphatidic acid (phosphatidate), Phosphatidylethanolamine (cephalin) (PE), Phosphatidylcholine (lecithin) (PC), Phosphatidylserine (PS), Phosphatidylinositol (PI), Phosphatidylinositol phosphate (PIP), Phosphatidylinositol bisphosphate (PIP2) ,Phosphatidylinositol triphosphate (PIP3), Ceramide phosphorylcholine (Sphingomyelin) (SPH), Ceramide phosphorylethanolamine (Sphingomyelin) (Cer-PE) ,Ceramide phosphoryllipid and any combination thereof.
  • Phosphatidic acid phosphatidate
  • Phosphatidylethanolamine cephalin
  • PC Phosphatidyl
  • aqueous preparation is in the form of a liquid, solution, lotion, mixture, compound, formulation, gel, cream, liquid infusion, spray, suspension, emulsion, emollient preparation, emollient moisturizer and any combination thereof.
  • Figure 4A presents a graph illustrating the effectiveness of the composition of the present invention on a pests' population comprising of 10 cockroaches.
  • Table 2 below presents the experimental results obtained upon dispersion of the two samples A and B on pests population.
  • Sample A contained 5g of the Razox composition of the present invention, which contains a mixture of: boro-glycerin complex in a range of about 65% by weight , EDTA in a range of about 0.5% by weight , 0.5% SLS, about 2% Magnesium sulphate, about 15% lecithin, about 7% paraffin wax, about 7% isopropanol, about 2% dextrose monohydrate and about 1% aromatic oil with concentration of about 2.5%.
  • Sample B included water tap
  • the Razox composition blocked the sensory system of the pest, thereby when exposed to water the pest drawn and died since its sensory system was dysfunctional.
  • FIG. 4B presents a graph illustrating the effectiveness of the composition Razox CAC of the present invention.
  • Example D Three samples were compared: a water sample (sample D), and the Razox CAC composition of the present invention (sample C).
  • Table 2 below presents the experimental results obtained upon dispersion of samples C, and D on a pests' population comprising of 10 cockroaches.
  • Sample C included 5g of the Razox CAC composition of the present invention, which contains a mixture of citric acid and glycerin complex in a range of about 65% by weight , EDTA in a range of about 0.5% by weight , 0.5% SLS, about 2% potassium permanganate, about 15% lecithin, about 7% paraffin wax, about 7% isopropanol, about 2% dextrose monohydrate, and about 1% aromatic oil with concentration of about 2.5%.
  • Sample D included water tap.
  • the inorganic salts magnesium sulphate, calcium chloride or potassium permanganate can be used interchangeably in the above compositions, Razox composition and Razox-CAC composition.

Abstract

A pest control composition comprising a coating composition. The composition comprises a combination of organo-metalloid complex and a phospholipid compound. The composition is useful for controlling pests in agricultural, veterinary and domestic situations.

Description

A PEST CONTROL COMPOSITION AND METHOD THEREOF
FIELD OF THE INVENTION
The present invention relates to novel compositions and methods for pest control. More particularly, the present invention relates to a coating composition which targets the respiratory and sensory system of the pest.
BACKGROUND OF THE INVENTION
A variety of compositions have been proposed for pest control and pesticide.
US patent app. No. 2014039013 provides chemical modulators of pest olfactory receptors. In particular, compounds and compositions are provided that can inhibit host targeting functions in pests. Method of employing such agents, and articles incorporating the same, are also presented.
PCT app. WO2006044060 relates to protective coated fruits and vegetables, and methods for the treatment of plants that reduces the incidence of pest and sunburn damage, and other stress-induced disorders of horticultural crops^
US patent No. 5221535 provides a process of preparing an emulsion of a solubilized compound, the compound being soluble in a physiologically acceptable aqueous or nonaqueous solvent, said process comprising: (1) adding a complexing agent to at least one said solvent containing at least one said compound, the agent being capable of forming a compound: agent complex; (b) adding an emulsifier to the solvent containing the compound and the complexing agent; and (c) forming an emulsion. The invention also provides a process of preparing a dispersion of a compound which is insoluble in a physiologically acceptable aqueous or nonaqueous solvent but only soluble in a physiologically unacceptable solvent, said process comprising: (a) adding said compound to at least one physiologically acceptable solvent; (b) adding a complexing agent to the compound plus solvent of (a); (c) further adding an emulsifier to the compound plus solvent plus complexing agent of (b); (d) forming a dispersion of said compound in said physiologically acceptable solvent
US patent No.5188837 presents a microsuspension system and method for its preparation is disclosed. The microsuspension contains lipospheres, which are solid, water-insoluble microparticles that have a layer of a phospholipid embedded on their surface. The core of the liposphere is a solid substance to be delivered, or a substance to be delivered that is dispersed in an inert solid vehicle, such as a wax.
In view of the above, it is still a long felt and unmet need for a composition with low toxicity that is specifically useful and effective in short time for pest-control.
SUMMARY OF THE INVENTION
It is hence one object of the present invention to provide a pest control composition comprises a coating composition, wherein said composition comprises a combination of organo-metalloid complex and a phospholipid compound.
It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein said composition is aqueous.
It is also an object of the present invention to provide a composition as mentioned in any of the above , for aerosol administration dispersible upon the pest body surface.
It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein said pest is a cockroach.
It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein said organo-metalloid complex comprises a mixture of boro-glycerin complex in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
It is hence one object of the present invention to provide a pest control composition comprises a combination of organo-metalloid complex and a phospholipid compound, wherein said organo-metalloid complex is a mixture of citric acid -glycerin in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight. It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein the combination of the boro-glycerin complex and aminopolycarboxylic compound in a predefined ratio, further configured to disrupt spiracle control in said pests, further increasing mortality of said pests.
It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein the combination of the citro-glycerin complex and aminopolycarboxylic compound in a predefined ratio further configured to disrupting spiracle control in said pests, further increasing mortality of said pests.
It is also an object of the present invention to provide a composition as mentioned in any of the above, the glycerin is configured to dissolve and to be reacted with the boric acid further configured to form a boro-glycerine complex.
It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein about 25% boric acid compound is mixed at 25 °c with about 75 % of glycerin further configured to form a boro-glycerine complex
It is also an object of the present invention to provide a composition as mentioned in any of the above, the glycerin is configured to dissolve and to be reacted with the citric acid further configured to form a citro-glycerine complex.
It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein about 25 % citric acid compound is mixed at 25 °c with about 75 % of glycerin further configured to form a citro-glycerine complex.
It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein said phospholipid compound comprises at least one substance selected from the group consisting of Phosphatidic acid (phosphatidate), Phosphatidylethanolamine (cephalin) (PE), Phosphatidylcholine (lecithin) (PC), Phosphatidylserine (PS), Phosphatidylinositol (PI), Phosphatidylinositol phosphate (PIP), Phosphatidylinositol bisphosphate (PIP2) ,Phosphatidylinositol triphosphate (PIP3), Ceramide phosphorylcholine (Sphingomyelin) (SPH), Ceramide phosphorylethanolamine (Sphingomyelin) (Cer-PE) ,Ceramide phosphoryllipid and any combination thereof.
It is also an object of the present invention to provide a composition as mentioned in any of the above,additionally comprising at least one substance selected from the group consisting of detergent, paraffin wax, aromatic oil, phospholipid, alcohol, dextrose monohydrate, inorganic salts selected from a group consisting magnesium sulphate, potassium permanganate calcium chloride, and any mixture thereof.
It is also an object of the present invention to provide a composition as mentioned in any of the above,, wherein said phospholipids when mixed with SLS forms micelles in an aqueous environment; said micelles dispersible on the cuticle of a pest forming at least one layer around on said pest cuticle.
It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein said aminopolycarboxylic acid is EDTA.
It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein said composition dispersed on a pest provides a thin coating layer upon the epicuticle of the pests for inhibition of pest host sensing.
It is also an object of the present invention to provide a composition as mentioned in any of the above,, wherein said composition impairs respiration of the pest, forming a barrier upon at least one selected from the group consisting of the pest body surface, the breathing spiracles, the sensory hairs and organs.
It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein said composition when layered on said cockroach in vivo and in contact with a substance selected from a group consisting water, moisture, humidity, and any combination thereof, facilitates entry of water via dysfunctional spiracles, into said insect , sufficient to kill said pest.
It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein said compositions have low toxicity. It is also an object of the present invention to provide a composition as mentioned in any of the above, further comprises at least one controlled-release formulation configured to maintain constant concentration of at least one of the ingredients of said compositions, for a specific period of time.
It is also an object of the present invention to provide a composition as mentioned in any of the above,, wherein said aqueous preparation is in the form of a liquid, solution, lotion, mixture, compound, formulation, gel, cream, liquid infusion, spray, suspension, emulsion, emollient preparation, emollient moisturizer and any combination thereof.
It is also an object of the present invention to provide a composition as mentioned in any of the above,, additionally comprising at least one substance selected from the group consisting of about 0.5% detergent, about 15% phospholipid compound, about 7% alcohol, about 1% aromatic oil with concentration of about 2.5% , about 7% paraffin wax, about 2% dextrose monohydrate, about 1% aromatic oil and about 2% inorganic salt selected from a group consisting magnesium sulphate, calcium chloride or potassium permanganate , and any mixture thereof.
It is also an object of the present invention to provide a composition as mentioned in any of the above, wherein additionally comprising a water solution in a ratio ranging from about 1: 10 to about 1:50, respectively.
It is hence one object of the present invention to provide a dispersing device for delivering an aerosolized spray of composition of claim 1, comprising: a housing having an internal cavity containing said pest control composition; and a control valve for delivering said composition from the cavity to a selected site; wherein the composition of claim 1 comprises said mixture of boro-glycerin complex or said mixture of citric acid -glycerin complex.
It is hence one object of the present invention to provide method for controlling pests comprising steps of providing a coating composition, and applying said composition to a location to be so controlled wherein said composition comprises a combination of organo-metalloid complex and a phospholipid compound. It is also an object of the present invention to provide a method as mentioned in any of the above, wherein said composition is aqueous.
It is also an object of the present invention to provide a method as mentioned in any of the above, comprising steps of aerosol administration and dispersion of said composition upon the pest body surface directly or indirectly.
It is also an object of the present invention to provide a method as mentioned in any of the above, wherein said pest is a cockroach.
It is also an object of the present invention to provide a method as mentioned in any of the above, wherein said organo-metalloid complex comprises a mixture of boro- glycerin complex in a range of about 65% by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
It is hence one object of the present invention to provide method for controlling pests comprising steps of providing a combination of organo-metalloid complex and a phospholipid compound, wherein said organo-metalloid complex is a mixture of citric acid -glycerin in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
It is also an object of the present invention to provide a method as mentioned in any of the above, comprising steps of providing a combination of the boro-glycerin complex and aminopolycarboxylic compound in a predefined ratio, disrupting spiracle control in said pests, further increasing mortality of said pests.
It is also an object of the present invention to provide a method as mentioned in any of the above, comprising steps of providing combination of the citro-glycerin complex and aminopolycarboxylic compound in a predefined ratio, disrupting spiracle control in said pests, further increasing mortality of said pests.
It is also an object of the present invention to provide a method as mentioned in any of the above, comprising steps of glycerin dissolving and reacting with the boric acid, further forming a boro-glycerine complex. It is also an object of the present invention to provide a method as mentioned in any of the above, wherein about 25% boric acid compound is mixing at 25 °c with about 75 % of glycerin further forming a boro-glycerine complex.
It is also an object of the present invention to provide a method as mentioned in any of the above, wherein the glycerin is dissolving further reacting with the citric acid further forming a citro-glycerine complex.
It is also an object of the present invention to provide a method as mentioned in any of the above wherein about 25 % citric acid compound is mixing at 25 °c with about 75 % of glycerin further forming a citro-glycerine complex.
It is also an object of the present invention to provide a method as mentioned in any of the above, wherein said phospholipid compound comprises at least one substance selected from the group consisting of Phosphatidic acid (phosphatidate), Phosphatidylethanolamine (cephalin) (PE), Phosphatidylcholine (lecithin) (PC), Phosphatidylserine (PS), Phosphatidylinositol (PI), Phosphatidylinositol phosphate (PIP), Phosphatidylinositol bisphosphate (PIP2) ,Phosphatidylinositol triphosphate (PIP3), Ceramide phosphorylcholine (Sphingomyelin) (SPH), Ceramide phosphorylethanolamine (Sphingomyelin) (Cer-PE) ,Ceramide phosphoryllipid and any combination thereof.
It is also an object of the present invention to provide a method as mentioned in any of the above, additionally comprising at least one substance selected from the group consisting of a detergent, paraffin wax, aromatic oil, phospholipid, alcohol, dextrose monohydrate, inorganic salts selected from a group consisting of magnesium sulphate, potassium permanganate calcium chloride, and any mixture thereof.
It is also an object of the present invention to provide a method as mentioned in any of the above, comprising steps of said phospholipids forming micelles in an aqueous environment when mixed with SLS; said micelles dispersing on the cuticle of a pest , further forming at least one layer around on said pest cuticle.
It is also an object of the present invention to provide a method as mentioned in any of the above, wherein said aminopolycarboxylic acid is EDTA. It is also an object of the present invention to provide a method as mentioned in any of the above, comprising steps of said composition dispersing on a pest, further providing a thin coating layer upon the epicuticle of the pests further inhibiting of pest host sensing.
It is also an object of the present invention to provide a method as mentioned in any of the above, comprising steps of said composition impairing respiration of the pest, further forming a barrier upon at least one selected from the group consisting of the pest body surface, the breathing spiracles, the sensory hairs and organs.
It is also an object of the present invention to provide a method as mentioned in any of the above, comprising steps of layering said composition in vivo on said cockroach further contacting a substance selected from a group consisting water, moisture, humidity, and any combination thereof , wherein further facilitating entry of water via dysfunctional spiracles, into said insect , sufficient to kill said pest.
It is also an object of the present invention to provide a method as mentioned in any of the above, wherein said compositions have low toxicity.
It is also an object of the present invention to provide a method as mentioned in any of the above, further comprising steps of providing at least one controlled-release formulation configured to maintain constant concentration of at least one of the ingredients of said compositions, for a specific period of time.
It is also an object of the present invention to provide a method as mentioned in any of the above, wherein said aqueous preparation is in the form of a liquid, solution, lotion, mixture, compound, formulation, gel, cream, liquid infusion, spray, suspension, emulsion, emollient preparation, emollient moisturizer and any combination thereof.
It is also an object of the present invention to provide a method as mentioned in any of the above, additionally comprising at least one substance selected from the group consisting of about 0.5% detergent , about 15% phospholipid compound, about 7% alcohol, about 1% aromatic oil with concentration of about 2.5%. about 7% paraffin wax, about 2% dextrose monohydrate aromatic oil and about 2% inorganic salt selected from a group consisting magnesium sulphate , calcium chloride or potassium permanganate , and any mixture thereof. It is also an object of the present invention to provide a method as mentioned in any of the above, wherein additionally comprising a water solution in a ratio ranging from about 1: 10 to about 1:50, respectively.BRIEF DESCRIPTION OF THE DRAWINGS In the following description of the preferred embodiments, reference is made to the accompanying drawings that form a part hereof, and in which are shown by way of illustration specific embodiments in which the invention may be practiced. It is understood that other embodiments may be utilized and structural changes may be made without departing from the scope of the present invention. The present invention may be practiced according to the claims without some or all of these specific details. For the purpose of clarity, technical material that is known in the technical fields related to the invention has not been described in detail so that the present invention is not unnecessarily obscured.
In the accompanying drawing: FIG. la-c presents the: (a) boro-glycerin complex,(b)citric acid , and (c) lecithin of the present invention.
FIG. 2 presents the sensor system of a pest;
FIG. 3 presents the cuticle system of a pest which the composition targets, of the present invention;
FIG. 4A presents a graph illustrating the effectiveness of the Razox composition of the present invention;
FIG. 4B presents a graph illustrating the effectiveness of the Razox-CAC composition of the present invention;
FIG. 5 presents the cockroach condition after exposure to the Razox composition (a combination of organo-metalloid complex and a phospholipid compound of the present invention) before contact with extraneous water; and
FIG.6 presents the pest condition after exposure to the Razox composition of the present invention and contact with water, resulting in ingress of water into the cockroach body and exploding of the cockroach.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
In the following detailed description of the preferred embodiments, reference is made to the accompanying drawings that form a part hereof, and in which are shown by way of illustration specific embodiments in which the invention may be practiced. It is understood that other embodiments may be utilized and structural changes may be made without departing from the scope of the present invention. The present invention may be practiced according to the claims without some or all of these specific details. For the purpose of clarity, technical material that is known in the technical fields related to the invention has not been described in detail so that the present invention is not unnecessarily obscured.
The essence of the present invention is to provide a composition for controlling pests and killing pests compositions. The pest control composition of the present invention is provided in forms which can be applied directly to plants, trees, orchards, fields, barns, hothouses, glasshouses, nurseries, growing rooms, livestock, pets, poultry and chicken houses, hatcheries and chicken-runs and the like, commonly used in agriculture. The pest control composition of the present invention can be provided in a form or format to be delivered directly on the relevant surfaces of the aforementioned or directly on the pests. The pest control composition of the present invention can be provided in a form or format to be used in habitations, houses, apartments, shops, stroes schools, ships aircraft and the like. The pest control composition of the present invention can be provided in a form or format to be delivered directly on the relevant surfaces of the aforementioned or directly on the pests. The pest-control composition comprises a combination of organo-metalloid complex such as boro-glycerine, compound of boric acid and glycerine (e.g antiseptic material) as illustrated in Figure la; or a combination of organo-metalloid complex such as citro-glycerine (Figure lb), compound of citric acid and glycerine and a phospholipid compound such as lecithin as illustrated in Figure lc.
The compositions are directed to inhibiting a wide variety of pests' species, especially agricultural and horticultural pests.
Reference is now made to Figure 2 which illustrates the sensory and nervous system of the pest. The composition targets and inhibits the functions of the sensors or/and the spiracle of the pest, forming a coating or a barrier around the pest body surface, more particularity blocking the breathing spiracles, sensory hairs and organs of the pest. Spiracles are openings on the thorax of hexapods, including insects. The spiracles open into chitinous tubes called tracheae which then further subdivide until becoming less than 1 mm in diameter tracheoles, forming a network all through the body of the organism, said network is the respiratory system of these organisms. The spiracles are muscular valves in the insect body, and their opening can be controlled, mostly in order to regulate water loss. This mechanism is controlled by the central nervous system but can also react to localized chemical stimuli. Several aquatic insects have similar or alternative closing methods to prevent water from entering the trachea. The timing and duration of spiracle closures can affect the respiratory rates of the organism.
The phospholipids of the composition provide a first layer which blocks the respiratory system of the pest and further inhibits the pest nervous system from environmental stimuluses.
The composition of the present invention targets the spiracles which act as muscular valves in some pests, lead to the internal respiratory system, a densely networked array of tubes called tracheae. This network of transverse and longitudinal tracheae equalizes pressure throughout the system.
Reference is now made to Figure 3 which illustrates the cuticle system of a pest which the composition of the present invention targets. The composition is formulated as contact pesticides which penetrate the pest cuticle or enter through the spiracles of the respiratory system.
The composition of the present invention is an aqueous preparation which may be in the form of a liquid, solution, lotion, mixture, compound, formulation, gel, cream, liquid infusion, spray, suspension, emulsion, emollient preparation, emollient moisturizer and any combination thereof.
The term "Pest" herein refers to a plant or animal detrimental to humans or human concerns (as agriculture or livestock production); alternative meaning includes organisms that cause nuisance and epidemic disease associated with high mortality. A pest is any living organism which is invasive or prolific, detrimental, troublesome, noxious, destructive, a nuisance to either plants or animals, human or human concerns, livestock, human structures, wild ecosystems etc. It is a loosely defined term, often overlapping with the related terms vermin, weed, plant and animal parasites and pathogens. It is possible for an organism to be a pest in one setting but beneficial, domesticated or acceptable in another.
It is further classified to invertebrate pests' species, plant pests' species, and vertebrate pests' species. The term "Razox composition" herein refers to one combination of organo-metalloid complex and a phospholipid compound. This combination is a mixture of: boro- glycerin complex in a range of about 65% by weight , EDTA in a range of about 0.5% by weight , 0.5% SLS, about 2% Magnesium sulphate, about 15% lecithin, about 7% paraffin wax, about 7% isopropanol, about 2% dextrose monohydrate and about 1% aromatic oil with concentration of about 2.5%.
The term "Razox-CAC composition" herein refers to another combination of organo- metalloid complex and a phospholipid compound. This combination is a mixture of citric acid and glycerin complex in a range of about 65% by weight , EDTA in a range of about 0.5% by weight , 0.5% SLS, about 2% potassium permanganate, about 15% lecithin, about 7% paraffin wax, about 7% isopropanol, about 2% dextrose monohydrate, and about 1% aromatic oil with concentration of about 2.5%.
The inorganic salts magnesium sulphate, calcium chloride or potassium permanganate can be used interchangeably in the above compositions, Razox composition and Razox-CAC composition.
In other embodiments of the present invention, the detergent SLS combined with boro-glycerin enables the adherence of the coating formation to the pest respiratory system. Since the pest body is covered with a hydrophobic fraction there is an improved adsorption of the boro-glycerin around the pest body whilst the lecithin and SLS as a mixture provides a binding substance which allows conjugation between the hydrophobic fraction to the hydrophilic fraction. This results in a higher entropic state which causes non-polar molecules to clump together to reduce the surface area exposed to water and decrease the entropy of the system.
In other embodiments of the present invention, the phospholipids e.g. lecithin when mixed with SLS forms micelles in an aqueous environment. The micelles target the cuticle of the pest thereby, forming a coated barrier around the pest body.
In other embodiments of the present invention, the Magnesium sulphate salt or Potassium permanganate is a hygroscopic material which enables the boro-glycerin complex comprising boric acid compound to be dissolved and provides an improved pesticide with low toxicity to the environment.
In other embodiments of the present invention, the glycerin is used as a solvent medium of the composition for dissolving and to be reacted with the boric acid forming a boro-glycerine complex. Thereby about 20 to 30% boric acid compound is mixed at 25 °c with about 70 to 80% of glycerin forming boro-glycerine complex In other embodiments of the present invention, the composition has low viscosity resulting from the alcohol compound.
Reference is now made to an embodiment of the present invention disclosing a pest control composition comprises a coating composition, wherein said composition comprises a combination of organo-metalloid complex and a phospholipid compound.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein said composition is aqueous.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, for aerosol administration dispersible upon the pest body surface.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein said pest is a cockroach.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein said organo-metalloid complex comprises a mixture of boro-glycerin complex in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
Reference is now made to an embodiment of the present invention disclosing a pest control composition comprises a combination of organo-metalloid complex and a phospholipid compound, wherein said organo-metalloid complex is a mixture of citric acid -glycerin in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein the combination of the boro-glycerin complex and aminopolycarboxylic compound in a predefined ratio, further configured to disrupt spiracle control in said pests, further increasing mortality of said pests.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein the combination of the citro-glycerin complex and aminopolycarboxylic compound in a predefined ratio further configured to disrupting spiracle control in said pests, further increasing mortality of said pests.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, the glycerin is configured to dissolve and to be reacted with the boric acid further configured to form a boro-glycerine complex.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein about 25% boric acid compound is mixed at 25 °c with about 75 % of glycerin further configured to form a boro-glycerine complex
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, the glycerin is configured to dissolve and to be reacted with the citric acid further configured to form a citro-glycerine complex.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein about 25 % citric acid compound is mixed at 25 °c with about 75 % of glycerin further configured to form a citro-glycerine complex.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein said phospholipid compound comprises at least one substance selected from the group consisting of Phosphatidic acid (phosphatidate), Phosphatidylethanolamine (cephalin) (PE), Phosphatidylcholine (lecithin) (PC), Phosphatidylserine (PS), Phosphatidylinositol (PI), Phosphatidylinositol phosphate (PIP), Phosphatidylinositol bisphosphate (PIP2) ,Phosphatidylinositol triphosphate (PIP3), Ceramide phosphorylcholine (Sphingomyelin) (SPH), Ceramide phosphorylethanolamine (Sphingomyelin) (Cer- PE) ,Ceramide phosphoryllipid and any combination thereof.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, additionally comprising at least one substance selected from the group consisting of detergent, paraffin wax, aromatic oil, phospholipid, alcohol, dextrose monohydrate, inorganic salts selected from a group consisting magnesium sulphate, potassium permanganate calcium chloride, and any mixture thereof.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein said phospholipids when mixed with SLS forms micelles in an aqueous environment; said micelles dispersible on the cuticle of a pest forming at least one layer around on said pest cuticle.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein said aminopolycarboxylic acid is EDTA.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein said composition dispersed on a pest provides a thin coating layer upon the epicuticle of the pests for inhibition of pest host sensing.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein said composition impairs respiration of the pest, forming a barrier upon at least one selected from the group consisting of the pest body surface, the breathing spiracles, the sensory hairs and organs.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein said composition when layered on said cockroach in vivo and in contact with a substance selected from a group consisting water, moisture, humidity, and any combination thereof, facilitates entry of water via dysfunctional spiracles, into said insect , sufficient to kill said pest.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein said compositions have low toxicity. Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, further comprises at least one controlled-release formulation configured to maintain constant concentration of at least one of the ingredients of said compositions, for a specific period of time.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein said aqueous preparation is in the form of a liquid, solution, lotion, mixture, compound, formulation, gel, cream, liquid infusion, spray, suspension, emulsion, emollient preparation, emollient moisturizer and any combination thereof.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, additionally comprising at least one substance selected from the group consisting of about 0.5% detergent, about 15% phospholipid compound, about 7% alcohol, about 1% aromatic oil with concentration of about 2.5% , about 7% paraffin wax, about 2% dextrose monohydrate, about 1% aromatic oil and about 2% inorganic salt selected from a group consisting magnesium sulphate, calcium chloride or potassium permanganate , and any mixture thereof.
Reference is now made to an embodiment of the present invention disclosing the composition mentioned above, wherein additionally comprising a water solution in a ratio ranging from about 1: 10 to about 1:50, respectively.
Reference is now made to an embodiment of the present invention disclosing a dispersing device for delivering an aerosolized spray of composition of claim 1, comprising: a housing having an internal cavity containing said pest control composition; and a control valve for delivering said composition from the cavity to a selected site; wherein the composition of claim 1 comprises said mixture of boro-glycerin complex or said mixture of citric acid -glycerin complex.
Reference is now made to an embodiment of the present invention disclosing a method for controlling pests comprising steps of providing a coating composition, and applying said composition to a location to be so controlled wherein said composition comprises a combination of organo-metalloid complex and a phospholipid compound. Reference is now made to an embodiment of the present invention disclosing the method mentioned above, wherein said composition is aqueous.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, comprising steps of aerosol administration and dispersion of said composition upon the pest body surface directly or indirectly.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, wherein said pest is a cockroach.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, wherein said organo-metalloid complex comprises a mixture of boro-glycerin complex in a range of about 65% by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
Reference is now made to an embodiment of the present invention disclosing a method for controlling pests comprising steps of providing a combination of organo-metalloid complex and a phospholipid compound, wherein said organo- metalloid complex is a mixture of citric acid -glycerin in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, method according to claim 30, comprising steps of providing a combination of the boro-glycerin complex and aminopolycarboxylic compound in a predefined ratio, disrupting spiracle control in said pests, further increasing mortality of said pests.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, comprising steps of providing combination of the citro- glycerin complex and aminopolycarboxylic compound in a predefined ratio, disrupting spiracle control in said pests, further increasing mortality of said pests. Reference is now made to an embodiment of the present invention disclosing the method mentioned above, comprising steps of glycerin dissolving and reacting with the boric acid, further forming a boro-glycerine complex.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, wherein about 25% boric acid compound is mixing at 25 °c with about 75 % of glycerin further forming a boro-glycerine complex.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, wherein the glycerin is dissolving further reacting with the citric acid further forming a citro-glycerine complex.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, wherein about 25 % citric acid compound is mixing at 25 °c with about 75 % of glycerin further forming a citro-glycerine complex.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, wherein said phospholipid compound comprises at least one substance selected from the group consisting of Phosphatidic acid (phosphatidate), Phosphatidylethanolamine (cephalin) (PE), Phosphatidylcholine (lecithin) (PC), Phosphatidylserine (PS), Phosphatidylinositol (PI), Phosphatidylinositol phosphate (PIP), Phosphatidylinositol bisphosphate (PIP2) ,Phosphatidylinositol triphosphate (PIP3), Ceramide phosphorylcholine (Sphingomyelin) (SPH), Ceramide phosphorylethanolamine (Sphingomyelin) (Cer-PE) ,Ceramide phosphoryllipid and any combination thereof.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, additionally comprising at least one substance selected from the group consisting of a detergent, paraffin wax, phospholipid, aromatic oil, alcohol, dextrose monohydrate, inorganic salts selected from a group consisting of magnesium sulphate, potassium permanganate calcium chloride, and any mixture thereof.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, comprising steps of said phospholipids forming micelles in an aqueous environment when mixed with SLS; said micelles dispersing on the cuticle of a pest, further forming at least one layer around on said pest cuticle.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, wherein said aminopolycarboxylic acid is EDTA.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, comprising steps of said composition dispersing on a pest, further providing a thin coating layer upon the epicuticle of the pests further inhibiting of pest host sensing.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, comprising steps of said composition impairing respiration of the pest, further forming a barrier upon at least one selected from the group consisting of the pest body surface, the breathing spiracles, the sensory hairs and organs.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, comprising steps of layering said composition in vivo on said cockroach further contacting a substance selected from a group consisting water, moisture, humidity, and any combination thereof , wherein further facilitating entry of water via dysfunctional spiracles, into said insect , sufficient to kill said pest.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, wherein said compositions have low toxicity.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, further comprising steps of providing at least one controlled-release formulation configured to maintain constant concentration of at least one of the ingredients of said compositions, for a specific period of time.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, wherein said aqueous preparation is in the form of a liquid, solution, lotion, mixture, compound, formulation, gel, cream, liquid infusion, spray, suspension, emulsion, emollient preparation, emollient moisturizer and any combination thereof. Reference is now made to an embodiment of the present invention disclosing the method mentioned above, additionally comprising at least one substance selected from the group consisting of about 0.5% detergent , about 15% phospholipid compound, about 7% alcohol, about 1% aromatic oil with concentration of about 2.5%. about 7% paraffin wax, about 2% dextrose monohydrate aromatic oil and about 2% inorganic salt selected from a group consisting magnesium sulphate , calcium chloride or potassium permanganate , and any mixture thereof.
Reference is now made to an embodiment of the present invention disclosing the method mentioned above, wherein additionally comprising a water solution in a ratio ranging from about 1: 10 to about 1:50, respectively.
EXAMPLES
Example 1:
Reference in now made to Figure 4A presents a graph illustrating the effectiveness of the composition of the present invention on a pests' population comprising of 10 cockroaches.
Two samples were compared: a water sample (sample B), and the Razox composition of the present invention (sample A).
Table 2 below presents the experimental results obtained upon dispersion of the two samples A and B on pests population.
Sample A contained 5g of the Razox composition of the present invention, which contains a mixture of: boro-glycerin complex in a range of about 65% by weight , EDTA in a range of about 0.5% by weight , 0.5% SLS, about 2% Magnesium sulphate, about 15% lecithin, about 7% paraffin wax, about 7% isopropanol, about 2% dextrose monohydrate and about 1% aromatic oil with concentration of about 2.5%. Sample B included water tap
As illustrated in the aforementioned Table 1, after an hour of dispersing the pest with the composition no dead pest was observed in sample A. This further illustrates that the composition is with low and even without any toxicity effect. However, after 5 mins of dispersing the pest with additional 15g of tap water when the coating compositing blocked the pests sensors, more than 40% of the population died by drowning.
TABLE 1
Figure imgf000022_0001
As illustrated in Figures 5-6, the Razox composition blocked the sensory system of the pest, thereby when exposed to water the pest drawn and died since its sensory system was dysfunctional.
Example 2:
Reference in now made to Figure 4B presents a graph illustrating the effectiveness of the composition Razox CAC of the present invention.
Three samples were compared: a water sample (sample D), and the Razox CAC composition of the present invention (sample C).
Table 2 below presents the experimental results obtained upon dispersion of samples C, and D on a pests' population comprising of 10 cockroaches.
Sample C included 5g of the Razox CAC composition of the present invention, which contains a mixture of citric acid and glycerin complex in a range of about 65% by weight , EDTA in a range of about 0.5% by weight , 0.5% SLS, about 2% potassium permanganate, about 15% lecithin, about 7% paraffin wax, about 7% isopropanol, about 2% dextrose monohydrate, and about 1% aromatic oil with concentration of about 2.5%. Sample D included water tap.
As illustrated in Table 2, following an hour of dispersing the pest with the composition no dead pest was observed in sample C. This further illustrates that the composition has low and even no toxic effects. However after 4 mins of dispersing the pest with additional 15g of tap water, when the coating compositing blocked the pests' sensors, 40% of the population died of drowning.
TABLE 2
Figure imgf000023_0001
The inorganic salts magnesium sulphate, calcium chloride or potassium permanganate can be used interchangeably in the above compositions, Razox composition and Razox-CAC composition.

Claims

1. A pest control composition comprises a coating composition, wherein said composition comprises a combination of organo-metalloid complex and a phospholipid compound.
2. The composition according to claim 1 wherein said composition is aqueous.
3. The composition according to claim 1 for aerosol administration dispersible upon the pest body surface.
4. The composition according to claim 1, wherein said pest is a cockroach.
5. The composition of claim 1, wherein said organo-metalloid complex comprises a mixture of boro-glycerin complex in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
6. A pest control composition comprises a combination of organo-metalloid complex and a phospholipid compound, wherein said organo-metalloid complex is a mixture of citric acid -glycerin in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
7. The composition of claim 5, wherein the combination of the boro-glycerin complex and aminopolycarboxylic compound in a predefined ratio, further configured to disrupt spiracle control in said pests, further increasing mortality of said pests.
8. The combination of claim 6, wherein the combination of the citro-glycerin complex and aminopolycarboxylic compound in a predefined ratio further configured to disrupting spiracle control in said pests, further increasing mortality of said pests.
9. The composition of claim 5, the glycerin is configured to dissolve and to be reacted with the boric acid further configured to form a boro-glycerine complex.
10. The composition of claim 5 wherein about 25% boric acid compound is mixed at 25 °c with about 75 % of glycerin further configured to form a boro- glycerine complex.
11. The composition of claim 6, the glycerin is configured to dissolve and to be reacted with the citric acid further configured to form a citro-glycerine complex.
12. The composition of claim 6, wherein about 25 % citric acid compound is mixed at 25 °c with about 75 % of glycerin further configured to form a citro- glycerine complex.
13. The composition of claim 1, wherein said phospholipid compound comprises at least one substance selected from the group consisting of Phosphatidic acid (phosphatidate), Phosphatidylethanolamine (cephalin) (PE), Phosphatidylcholine (lecithin) (PC), Phosphatidylserine (PS), Phosphatidylinositol (PI), Phosphatidylinositol phosphate (PIP), Phosphatidylinositol bisphosphate (PIP2) ,Phosphatidylinositol triphosphate (PIP3), Ceramide phosphorylcholine (Sphingomyelin) (SPH), Ceramide phosphorylethanolamine (Sphingomyelin) (Cer-PE) ,Ceramide phosphoryllipid and any combination thereof.
14. The composition according to claims 5 or 6, additionally comprising at least one substance selected from the group consisting of detergent, paraffin wax, aromatic oil, alcohol, phospholipid, dextrose monohydrate, inorganic salts selected from a group consisting magnesium sulphate, potassium permanganate calcium chloride, and any mixture thereof.
15. The composition according to claim 1, wherein said phospholipids when mixed with SLS forms micelles in an aqueous environment; said micelles dispersible on the cuticle of a pest forming at least one layer around on said pest cuticle.
16. The composition according to claims 5 or 6, wherein said aminopolycarboxylic acid is EDTA.
17. The composition according to claims 5 or 6, wherein said composition dispersed on a pest provides a thin coating layer upon the epicuticle of the pests for inhibition of pest host sensing.
18. The composition according to claims 5 or 6, wherein said composition impairs respiration of the pest, forming a barrier upon at least one selected from the group consisting of the pest body surface, the breathing spiracles, the sensory hairs and organs.
19. The composition according to claiml, wherein said composition when layered on said cockroach in vivo and in contact with a substance selected from a group consisting water, moisture, humidity, and any combination thereof , facilitates entry of water via dysfunctional spiracles, into said insect , sufficient to kill said pest.
20. The compositions according to claims 5 or 6, wherein said compositions have low toxicity.
21. The compositions according to claims 5 or 6, further comprises at least one controlled-release formulation configured to maintain constant concentration of at least one of the ingredients of said compositions, for a specific period of time.
22. The composition according to claiml, wherein said aqueous preparation is in the form of a liquid, solution, lotion, mixture, compound, formulation, gel, cream, liquid infusion, spray, suspension, emulsion, emollient preparation, emollient moisturizer and any combination thereof.
23. The composition of claim 1, additionally comprising at least one substance selected from the group consisting of about 0.5% detergent, about 15% phospholipid compound, about 7% alcohol, about 1% aromatic oil with concentration of about 2.5% , about 7% paraffin wax, about 2% dextrose monohydrate, about 1% aromatic oil and about 2% inorganic salt selected from a group consisting magnesium sulphate, calcium chloride or potassium permanganate , and any mixture thereof.
24. The composition according to claim 1, wherein additionally comprising a water solution in a ratio ranging from about 1: 10 to about 1:50, respectively.
25. A dispersing device for delivering an aerosolized spray of composition of claim 1, comprising: a housing having an internal cavity containing said pest control composition; and a control valve for delivering said composition from the cavity to a selected site; wherein the composition of claim 1 comprises said mixture of boro-glycerin complex or said mixture of citric acid - glycerin complex.
26. A method for controlling pests comprising steps of providing a coating composition, and applying said composition to a location to be so controlled wherein said composition comprises a combination of organo- metalloid complex and a phospholipid compound.
27. The method according to claim 26, wherein said composition is aqueous.
28. The method according to claim 26, comprising steps of aerosol administration and dispersion of said composition upon the pest body surface directly or indirectly.
29. The method according to claim 26, wherein said pest is a cockroach.
30. The method according to claim 26, wherein said organo-metalloid complex comprises a mixture of boro-glycerin complex in a range of about 65% by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
31. A method for controlling pests comprising steps of providing a combination of organo-metalloid complex and a phospholipid compound, wherein said organo-metalloid complex is a mixture of citric acid -glycerin in a range of about 65 % by weight and aminopolycarboxylic acid compound in a range of about 0.5% by weight.
32. The method according to claim 30, comprising steps of providing a combination of the boro-glycerin complex and aminopolycarboxylic compound in a predefined ratio, disrupting spiracle control in said pests, further increasing mortality of said pests.
33. The method according to claim 31, comprising steps of providing combination of the citro-glycerin complex and aminopolycarboxylic compound in a predefined ratio, disrupting spiracle control in said pests, further increasing mortality of said pests.
34. The method according to claim 30, comprising steps of glycerin dissolving and reacting with the boric acid, further forming a boro-glycerine complex.
35. The method according to claim 31, wherein about 25% boric acid compound is mixing at 25 °c with about 75 % of glycerin further forming a boro- glycerine complex.
36. The method according to claim 30, wherein the glycerin is dissolving further reacting with the citric acid further forming a citro -glycerine complex.
37. The method of claim 31 wherein about 25 % citric acid compound is mixing at 25 °c with about 75 % of glycerin further forming a citro-glycerine complex.
38. The method of claim 26, wherein said phospholipid compound comprises at least one substance selected from the group consisting of Phosphatidic acid (phosphatidate), Phosphatidylethanolamine (cephalin) (PE), Phosphatidylcholine (lecithin) (PC), Phosphatidylserine (PS), Phosphatidylinositol (PI), Phosphatidylinositol phosphate (PIP), Phosphatidylinositol bisphosphate (PIP2) ,Phosphatidylinositol triphosphate (PIP3), Ceramide phosphorylcholine (Sphingomyelin) (SPH), Ceramide phosphorylethanolamine (Sphingomyelin) (Cer-PE) ,Ceramide phosphoryllipid and any combination thereof.
39. The method according to claims 30 or 31, additionally comprising at least one substance selected from the group consisting of detergent, paraffin wax, aromatic oil, alcohol, phospholipid, dextrose monohydrate, inorganic salts selected from a group consisting of magnesium sulphate, potassium permanganate calcium chloride, and any mixture thereof.
40. The method according to claim 39, comprising steps of said phospholipids forming micelles in an aqueous environment when mixed with SLS; said micelles dispersing on the cuticle of a pest , further forming at least one layer around on said pest cuticle.
41. The method according to claims 30 or 31, wherein said aminopolycarboxylic acid is EDTA.
42. The method according to claim 26, comprising steps of said composition dispersing on a pest, further providing a thin coating layer upon the epicuticle of the pests further inhibiting of pest host sensing.
43. The method according to claims 30 or 31, comprising steps of said composition impairing respiration of the pest, further forming a barrier upon at least one selected from the group consisting of the pest body surface, the breathing spiracles, the sensory hairs and organs.
44. The method according to claim 26, comprising steps of layering said composition in vivo on said cockroach further contacting a substance selected from a group consisting water, moisture, humidity, and any combination thereof , wherein further facilitating entry of water via dysfunctional spiracles, into said insect , sufficient to kill said pest.
45. The methods according to claims 30 and 31, wherein said compositions have low toxicity.
46. The methods according to claims 30 and 31, further comprising steps of providing at least one controlled-release formulation configured to maintain constant concentration of at least one of the ingredients of said compositions, for a specific period of time.
47. The method according to claim 26, wherein said aqueous preparation is in the form of a liquid, solution, lotion, mixture, compound, formulation, gel, cream, liquid infusion, spray, suspension, emulsion, emollient preparation, emollient moisturizer and any combination thereof.
48. The method according to claim 26, additionally comprising at least one substance selected from the group consisting of about 0.5% detergent , about 15% phospholipid compound, about 7% alcohol, about 1% aromatic oil with concentration of about 2.5%. about 7% paraffin wax, about 2% dextrose monohydrate aromatic oil and about 2% inorganic salt selected from a group consisting magnesium sulphate , calcium chloride or potassium permanganate , and any mixture thereof.
49. The method according to claim 26, wherein additionally comprising a water solution in a ratio ranging from about 1: 10 to about 1:50, respectively.
PCT/IL2017/050973 2016-08-31 2017-08-31 A pest control composition and method thereof WO2018042435A1 (en)

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11028030B2 (en) 2015-12-10 2021-06-08 Apeel Technology, Inc. Plant extract compositions for forming protective coatings
CN113038824A (en) * 2018-09-05 2021-06-25 阿比尔技术公司 Compounds and formulations for protective coatings
US11160287B2 (en) 2015-05-20 2021-11-02 Apeel Technology, Inc. Plant extract compositions and methods of preparation thereof
US11319275B2 (en) 2016-11-17 2022-05-03 Apeel Technology, Inc. Compositions formed from plant extracts and methods of preparation thereof
US11447646B2 (en) 2015-09-16 2022-09-20 Apeel Technology, Inc. Precursor compounds for molecular coatings
US11641865B2 (en) 2020-03-04 2023-05-09 Apeel Technology, Inc. Compounds and formulations for protective coatings
US11723377B2 (en) 2016-01-26 2023-08-15 Apeel Technology, Inc. Method for preparing and preserving sanitized products
US11827591B2 (en) 2020-10-30 2023-11-28 Apeel Technology, Inc. Compositions and methods of preparation thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008157664A1 (en) * 2007-06-19 2008-12-24 Cellular Bioengineering, Inc. Method for treating microorganisms and/or infectious agents
US20110256196A1 (en) * 2007-06-07 2011-10-20 Nisus Corporation Insecticide for Bed Bugs
US20110287108A1 (en) * 2008-11-28 2011-11-24 Bayer Cropscience Ag Pesticide composition comprising a tetrazolyloxime derivative and a fungicide or an insecticide active substance
US9420779B1 (en) * 2008-11-12 2016-08-23 Green Dragon Pest Solutions, Inc. Insect baits

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110256196A1 (en) * 2007-06-07 2011-10-20 Nisus Corporation Insecticide for Bed Bugs
WO2008157664A1 (en) * 2007-06-19 2008-12-24 Cellular Bioengineering, Inc. Method for treating microorganisms and/or infectious agents
US9420779B1 (en) * 2008-11-12 2016-08-23 Green Dragon Pest Solutions, Inc. Insect baits
US20110287108A1 (en) * 2008-11-28 2011-11-24 Bayer Cropscience Ag Pesticide composition comprising a tetrazolyloxime derivative and a fungicide or an insecticide active substance

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11160287B2 (en) 2015-05-20 2021-11-02 Apeel Technology, Inc. Plant extract compositions and methods of preparation thereof
US11812758B2 (en) 2015-05-20 2023-11-14 Apeel Technology, Inc. Plant extract compositions and methods of preparation thereof
US11447646B2 (en) 2015-09-16 2022-09-20 Apeel Technology, Inc. Precursor compounds for molecular coatings
US11472970B2 (en) 2015-09-16 2022-10-18 Apeel Technology, Inc. Precursor compounds for molecular coatings
US11028030B2 (en) 2015-12-10 2021-06-08 Apeel Technology, Inc. Plant extract compositions for forming protective coatings
US11767278B2 (en) 2015-12-10 2023-09-26 Apeel Technology, Inc. Plant extract compositions for forming protective coatings
US11723377B2 (en) 2016-01-26 2023-08-15 Apeel Technology, Inc. Method for preparing and preserving sanitized products
US11319275B2 (en) 2016-11-17 2022-05-03 Apeel Technology, Inc. Compositions formed from plant extracts and methods of preparation thereof
US11918003B2 (en) 2016-11-17 2024-03-05 Apeel Technology, Inc. Compositions formed from plant extracts and methods of preparation thereof
CN113038824A (en) * 2018-09-05 2021-06-25 阿比尔技术公司 Compounds and formulations for protective coatings
US11641865B2 (en) 2020-03-04 2023-05-09 Apeel Technology, Inc. Compounds and formulations for protective coatings
US11827591B2 (en) 2020-10-30 2023-11-28 Apeel Technology, Inc. Compositions and methods of preparation thereof

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