WO2018039297A1 - Complément alimentaire macro/micronutritionnel pour patients subissant une dialyse rénale - Google Patents

Complément alimentaire macro/micronutritionnel pour patients subissant une dialyse rénale Download PDF

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WO2018039297A1
WO2018039297A1 PCT/US2017/048126 US2017048126W WO2018039297A1 WO 2018039297 A1 WO2018039297 A1 WO 2018039297A1 US 2017048126 W US2017048126 W US 2017048126W WO 2018039297 A1 WO2018039297 A1 WO 2018039297A1
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per unit
unit dose
amount
vitamin
pharmaceutically
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PCT/US2017/048126
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Atif DABDOUB
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Dabdoub Atif
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Priority claimed from SE1651259A external-priority patent/SE542106C2/en
Application filed by Dabdoub Atif filed Critical Dabdoub Atif
Priority to US16/326,250 priority Critical patent/US11077085B2/en
Priority to EP17844320.6A priority patent/EP3503745B1/fr
Priority to JP2019531865A priority patent/JP7012724B2/ja
Publication of WO2018039297A1 publication Critical patent/WO2018039297A1/fr
Priority to US17/389,719 priority patent/US20210353578A1/en

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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52Adding ingredients
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16Inorganic salts, minerals or trace elements
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/175Amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415Pyridoxine, i.e. Vitamin B6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51Thiamines, e.g. vitamin B1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525Isoalloxazines, e.g. riboflavins, vitamin B2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135Compounds containing heavy metals
    • A61K31/714Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/26Iron; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/30Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • Kidney Disease http://www.lifeextension.com/protocols/kidnev-urinary/kidnev-disease/page-04 High blood pressure, elevated blood sugar (including the presence of diabetes), high-protein diets, smoking, obesity, family history of kidney disease or failure, and a patient's history of heart problems all threaten the health of the kidneys, inflicting damage that has the potential to be lethal. In many cases, when the kidneys fail to perform adequately, kidney dialysis is required.
  • Essential amino acids such as L-carnitine can be essentially lost (70-80%) during dialysis; L-carnitine deficiency is associated with muscle aches and fatigue, confusion, hypoglycemia, cardiomyopathy, fatty liver, muscle necrosis, abnormal lipid storage, and other conditions.
  • Oxidative stress which is caused by an excess of free radicals and harmful molecules that can damage basic cellular constituents such as lipids, proteins, and DNA, can result from L-carnitine deficiency and is an especially dangerous condition for patients undergoing dialysis. Inadequate energy management in cardiac tissues brought on by L-carnitine deficiency can lead to cardiovascular complications including heart attack and heart failure. Further stressors include an excessive filtration burden on the kidneys resulting from the need to handle advanced glycation and lipoxidation end products and inflammation, especially when kidney function decreased to the point that dialysis is required. Many essential nutrients, including water-soluble vitamins such as B complex vitamins and vitamin C and minerals such as zinc and selenium are depleted from the body during dialysis treatment.
  • vitamin D which is primarily produced by the healthy kidney and, in case of kidney failure, vitamin D synthesis ceases, or, is significantly affected.
  • a nutritional supplement that can replenish the supply of basic nutrients to the body that are lost by dialysis, without providing the excess of fat soluble vitamins that could be damaging in high quantities.
  • this supplement would also provide nutrients, including but not limited to L-carnitine, that support overall kidney health and combat the effects of oxidative stress.
  • the supplement would ideally provide coenzyme Q10, which is a key component of the mitochondrial electron transport chain that is known to be important to mitochondrial energy generation (i.e., ATP synthesis).
  • coenzyme Q10 which is a key component of the mitochondrial electron transport chain that is known to be important to mitochondrial energy generation (i.e., ATP synthesis).
  • polyunsaturated fatty acids such as, for example, marine omega 3 fatty acids, are also removed from the body with chronic kidney dialysis. These compounds are lipid soluble macronutrients that are important to metabolism (i.e., energy production captured in the form of ATP).
  • the present invention addresses these needs by providing a nutritional supplement that will address the damaging effects of chronic kidney dialysis on the body.
  • a nutritional supplement designed to support kidney and cardiac function as well as mitochondrial energy function needs in patients undergoing hemodialysis. This supplement replenishes essential vitamins and minerals that are lost during dialysis, does not contain compounds that may specifically cause harm to dialysis patients, and provides support for tissues undergoing oxidative stress.
  • the nutritional supplements described herein may optionally contain turmeric, where the turmeric may or may not be present.
  • the term "about” is used to provide flexibility to a numerical range endpoint by providing that a given value may be “a little above” or “a little below” the endpoint without affecting the desired result.
  • Unit dose refers to a discrete amount of formulation to be administered to a subject.
  • the compositions and formulations disclosed herein are packaged into discrete dosages each containing predetermined quantities of active compounds calculated based on the needs and medical history of the subject.
  • a "pharmaceutically-acceptable compound” is used to refer to a neutral complex.
  • a pharmaceutically-acceptable compound may be more economical to produce, may have increased chemical stability, may allow manipulation of the compound's pharmacokinetics and bioavailability, may make the compound easier to administer, or a combination thereof.
  • a pharmaceutically-acceptable compound can alter a compound's dissolution or solubility.
  • the pharmaceutically-acceptable compound can be an ionic compound.
  • the pharmaceutically-acceptable compound can be the reaction product between an organic acid (e.g., citric acid) and base (e.g., calcium hydroxide) to produce the ionic compound calcium citrate.
  • X and Y are present at a weight ratio of 2:5, and are present in such ratio regardless of whether additional components are contained in the compound.
  • each of the combinations A + E, A + F, B + D, B + E, B + F, C + D, C + E, and C + F is specifically contemplated and should be considered from disclosure of A, B, and C; D, E, and F; and the example combination of A + D.
  • any subset or combination of these is also specifically contemplated and disclosed.
  • the sub-group of A + E, B + F, and C + E is specifically contemplated and should be considered from disclosure of A, B, and C; D, E, and F; and the example combination of A + D.
  • This concept applies to all aspects of the disclosure including, but not limited to, steps in methods of making and using the disclosed compositions.
  • steps in methods of making and using the disclosed compositions are a variety of additional steps that can be performed with any specific embodiment or combination of embodiments of the disclosed methods, each such combination is specifically contemplated and should be considered disclosed.
  • a vitamin is an organic compound that is required in small quantities to support essential body functions including growth and cellular maintenance.
  • vitamins cannot be produced by the body (e.g., vitamin C) or are not produced in sufficient quantities to meet a patient's needs and must be supplied via external sources.
  • Handbook of Nonprescription Drugs 1 1 th edition, 1996, American Pharmaceutical Association. 2215 Constitution Avenue, NW, Washington, DC 20037. Chapter 19, Nutritional Products, page 361 .
  • many diets are insufficient in one or more key vitamins and supplements are often indicated, especially in the cases of chronically ill individuals such as patients undergoing kidney dialysis.
  • a vitamin can act as a cofactor to assist an enzyme in carrying out an essential biochemical reaction.
  • the formulations disclosed herein include one or more water soluble vitamins.
  • water-soluble vitamins are depleted during kidney dialysis and should be replenished to maintain overall health and well- being.
  • the supplement disclosed herein provides water- soluble vitamins including the B complex vitamins and vitamin C.
  • the formulations disclosed herein include one or more B vitamins.
  • B vitamins generally act as cofactors or coenzymes or precursors needed to make cofactors or coenzymes.
  • B vitamins are not stored in the body and must be regularly supplied by dietary or other means to avoid deficiency.
  • co-supplementation of vitamins B 6 , B 9, and B 12 along with iron is especially effective against osteoporosis and anemia while also improving immune function.
  • all B complex vitamins can be used instead of just one or two.
  • low levels of B vitamins can affect the manufacture of neurotransmitters and contribute to stress and anxiety.
  • supplementation of B vitamins can reduce stress related to their deficiency.
  • low levels of B vitamins are caused by chronic kidney dialysis, the use of diuretics, and overconsumption of refined carbohydrates, since digestion of many carbohydrates requires the use of B vitamins.
  • inadequate B vitamin intake is linked to blood sugar surges in patients who consume too many refined carbohydrates.
  • thiamin or vitamin Bi , is included in the formulations disclosed herein.
  • thiamin may be important to nerve and muscle health, production of hydrochloric acid in the stomach, and treatment of constipation and fatigue, as well as assisting digestion of some carbohydrates and proteins.
  • the thiamine source is thiamine mononitrate.
  • the amount of vitamin present per unit dose is from 0.1 mg to 50 mg, 0.1 mg to 25 mg, 0.1 mg to 10 mg, 0.1 mg to 5 mg, 0.1 mg to 2 mg, or 0.1 mg to 1 mg.
  • 0.5 mg to 2 mg of thiamine is present per unit dose of the supplement.
  • riboflavin or vitamin B 2
  • riboflavin may be important for growth, red blood cell production, and eye health, as well as assisting in the digestion of some carbohydrates, fats, ketone bodies, and proteins.
  • the riboflavin source is molecular riboflavin.
  • the amount of vitamin B 2 present per unit dose is from 0.1 mg to 2 mg, 0.5 mg to 2 mg, or 0.5 mg to 1 mg. In another aspect, 0.5 to 2 mg of riboflavin is present per unit dose of the supplement.
  • nicotinic acid or nicotinamide also known as niacinamide or vitamin B 3
  • vitamin B 3 is important to digestive system health and may assist in the digestion of some carbohydrates, as well as in the production of various sex and stress-related hormones.
  • niacin may be useful in reducing cholesterol levels in the blood.
  • the niacinamide source is molecular niacinamide.
  • the amount of vitamin B 3 present per unit dose is from 1 mg to 40 mg, 5 mg to 30 mg, or 5 mg to 25 mg. In another aspect, 5 to 25 mg of niacinamide is present per unit dose of the supplement.
  • the formulations disclosed herein include pantothenic acid, or vitamin B 5 .
  • pantothenic acid may be important for red blood cells production, digestive system health, adrenal gland health, and the digestion of some carbohydrates.
  • the pantothenate source is D-calcium pantothenate.
  • the amount of vitamin B 5 present per unit dose is from 1 mg to 20 mg, 1 mg to 15 mg, or 5 mg to 10 mg. In another aspect, 5 to 10 mg of L- or D-calcium pantothenate is present per unit dose of the supplement.
  • the formulations disclosed herein include pyridoxal phosphate (also occurring as pyridoxine), or vitamin B 6 .
  • pyridoxal phosphate may be important for brain health and the production of red blood cells and immune system cells.
  • deficiencies in vitamin B 6 have been linked to diabetes, nervous system disorders, and heart disease.
  • the pyridoxine source is pyridoxine hydrochloride.
  • the amount of vitamin B 6 present per unit dose is from 1 mg to 100 mg, 1 mg to 50 mg, or 1 mg to 10 mg. In another aspect, 1 to 10 mg of pyridoxine hydrochloride is present per unit dose of the supplement.
  • the formulations disclosed herein include biotin, or vitamin B 7 .
  • biotin is important to various aspects of metabolism and may be important in strengthening the hair and nails as well as in the metabolism of fats and amino acids.
  • the biotin source is molecular biotin.
  • the amount of vitamin B 7 present per unit dose is from 10 ⁇ g to 500 ⁇ g, 10 ⁇ g to 300 ⁇ g, or 10 ⁇ g to 100 ⁇ g. In another aspect, 10 to 100 ⁇ g of biotin is present per unit dose of the supplement.
  • the formulations disclosed herein include folate, also known as folic acid or vitamin B 9 .
  • folic acid may be important for brain function, mental health, red blood cells production, and production of nucleic acids.
  • the folate source is folic acid.
  • the amount of vitamin B 9 present per unit dose is from 0.05 mg to 1 mg, 0.1 mg to 1 mg, or 0.1 mg to 0.5 mg. In another aspect, 0.2 to 0.4 mg of folic acid is present per unit dose of the supplement.
  • cobalamin or vitamin B 12
  • the cobalamin may be present as the cyanocobalamin, hydroxycobalamin, adenosylcobalamin, or methylcobalamin form.
  • cobalamin is important to nervous system health, the production of red blood cells, and synthesis of nucleic acids.
  • cobalamin works synergistically with folate with respect to red blood cell production.
  • the cobalamin source is cyanocobalamin.
  • the amount of vitamin B 12 present per unit dose is from 1 ⁇ g to 150 ⁇ g, 1 ⁇ g to 100 ⁇ g, 1 ⁇ g to 50 ⁇ g, 1 ⁇ g to 25 ⁇ g, or 1 ⁇ g to 10 ⁇ g. In another aspect, 3 to 6 ⁇ g of cyanocobalamin is present per unit dose of the supplement.
  • the formulations disclosed herein include ascorbic acid or vitamin C.
  • vitamin C is important to the immune system, collagen production, and wound healing. Further in this aspect, vitamin C is needed for the biosynthesis of hydroxyproline, which is important in the synthesis of collagen, osteoid, and dentin.
  • vitamin C is a potent antioxidant that can fight free radical damage.
  • vitamin C may assist with the uptake of non-heme iron.
  • vitamin C helps to protect folate from oxidative damage.
  • the amount of vitamin C present per unit dose is from 10 mg to 2,000 mg, 10 mg to 1 ,500 mg, 10 mg to 1 ,000 mg, 100 mg to 500 mg, or 100 mg to 300 mg. In another aspect, 100 to 300 mg of vitamin C (as ascorbic acid) is provided per unit dose of the supplement.
  • Fat-soluble vitamins are absorbed in the small intestine and are stored in and can accumulate in body tissues. In some aspects, when excessive quantities of fat-soluble items are ingested, this can be toxic to the body.
  • vitamins A, E, and K can accumulate to toxic levels in body tissue of patients undergoing dialysis. Handbook of Nonprescription Drugs, 1 1 th edition, 1996, American Pharmaceutical Association. 2215 Constitution Avenue, NW, Washington, DC 20037. Chapter 19, Nutritional Products, page 366. Further in this aspect, supplementation of these vitamins for kidney dialysis patients is contraindicated. In another aspect, the supplements disclosed herein do not include vitamins A, E, and K.
  • vitamin D is a fat-soluble vitamin that is usually activated by healthy or well-functioning kidneys.
  • the body in the case of kidney failure, the body cannot produce enough vitamin D and it should be supplemented in patients with kidney failure.
  • a patient's medical providers may decide vitamin D supplementation is not required and/or would cause further harm.
  • the supplement may or may not include a source of vitamin D, to be given at the discretion of healthcare providers on a case-by-case basis.
  • vitamin D when included in the formulations disclosed herein, it may improve bone health and immune system function and may protect against certain cancers.
  • vitamin D can increase calcium and phosphate absorption from the small intestine, is important in bone mineralization, and maintains proper calcium and phosphorus levels in the serum. Handbook of Nonprescription Drugs, 1 1 th edition, 1996, American Pharmaceutical Association. 2215 Constitution Avenue, NW, Washington, DC 20037. Chapter 19, Nutritional Products, page 368.
  • the amount of vitamin D present per unit dose is from 1 ⁇ g to 100 ⁇ g, 1 ⁇ g to 50 ⁇ g, or 1 ⁇ g to 20 ⁇ g. In another aspect, 5 to 10 ⁇ g of vitamin D (as cholecalciferol) are provided per unit dose of the supplements disclosed herein.
  • a mineral is an inorganic element that is obtained from food or supplementation and is required for the functioning of the human body.
  • Minerals include, but are not limited to, calcium, chromium, copper, iron, magnesium, manganese, molybdenum, nickel, potassium, selenium, sodium, vanadium, cobalt, and zinc.
  • a mineral can act as a cofactor.
  • minerals can be used for cell signaling, or can be an essential structural component of the body (e.g., calcium in bone), or can associate with proteins, nucleic acids, lipids, and carbohydrates to maintain particular secondary, tertiary, and quaternary structures.
  • the mineral can be part of a chelate complex.
  • Chelates have a cyclic structure in which a central metallic ion is held tight via covalent- coordinate bonds to form a coordinate compound, or, a chelate complex.
  • chelates occur abundantly in nature; for example, chlorophyll complexed with magnesium, hemoglobin with iron, Vitamin B12 with cobalt hemocyanin with copper as well as enzymes that contain vanadium or molybdenum.
  • the supplements disclosed herein include a number of important minerals.
  • the formulations disclosed herein include a pharmaceutically-acceptable compound of calcium.
  • calcium supplementation can be useful in preventing osteoporosis since calcium is a major component of bones and teeth.
  • calcium's absorption and effects are enhanced or aided by vitamin D and parathyroid hormone.
  • calcium may be important to B complex vitamin absorption and is important to the functional integrity of many cells.
  • calcium requirements may increase with increased protein consumption.
  • the calcium is provided as an ionic compound of calcium.
  • the formulations described herein include an ionic compound of calcium in an amount such that there is 100 mg to 2,500 mg, 100 mg to 2,000 mg, 100 mg to 1 ,500 mg, 100 mg to 1 ,000 mg, or 100 mg to 750 mg of calcium per unit dose.
  • calcium citrate tetrahydrate has a molecular weight of 570.49, of which calcium is 21 .08%.
  • 500 mg of calcium per unit dose there will be approximately 2,372.3 mg of calcium citrate tetrahydrate per unit dose.
  • 250 to 500 mg of calcium is provided per unit dose of the supplements disclosed herein.
  • the formulations disclosed herein include a pharmaceutically-acceptable compound of magnesium.
  • magnesium is necessary for the proper functioning of calcium in the body such as, for example, assisting in entry of calcium ions into cells, thus preventing calcification of tissues.
  • magnesium supplementation may support healthy heart function.
  • magnesium is required for normal bone structure formation and the functioning of several hundred enzymes, especially those with ATP- dependent phosphorylation, protein synthesis, and carbohydrate metabolism.
  • magnesium in the extracellular matrix is important to electrical potentials in nerve and muscle cells and the transmission of impulses across neuromuscular junctions.
  • the magnesium is provided as an ionic compound of magnesium.
  • examples of such compounds include, but are not limited to, magnesium citrate, magnesium sulfate monohydrate or heptahydrate, magnesium acetate tetrahydrate, magnesium D-gluconate hydrate, or magnesium nitrate hexahydrate.
  • the formulations described herein include an ionic compound of magnesium in an amount such that there is 100 mg to 500 mg, 150 mg to 500 mg, 200 mg to 500 mg, 250 mg to 500 mg, or 300 mg to 500 mg of magnesium per unit dose.
  • the formulations disclosed herein include a pharmaceutically-acceptable compound of zinc.
  • zinc is especially depleted (from 40% to 78%) during dialysis.
  • zinc is anti-inflammatory, anti-depressant, and functions to support the immune system. Handbook of Nonprescription Drugs, 1 1 th edition, 1996, American Pharmaceutical Association. 2215 Constitution Avenue, NW, Washington, DC 20037. Chapter 19, Nutritional Products, page 388.
  • zinc is integral to the function of many metalloenzymes and is a cofactor in the synthesis of nucleic acids.
  • zinc is important in the mobilization of vitamin A from the liver and in several reproductive system hormones and functions in both men and women.
  • the zinc is provided as an ionic compound of zinc.
  • examples of such compounds include, but are not limited to, zinc citrate, zinc citrate dihydrate, zinc acetate dihydrate, or zinc nitrate hexahydrate.
  • the formulations described herein include an ionic compound of zinc in an amount such that there is 1 mg to 40 mg, 1 mg to 30 mg, 1 mg to 20 mg, or 5 mg to 20 mg of zinc per unit dose.
  • the formulations disclosed herein include a pharmaceutically-acceptable compound of selenium.
  • selenium is highly concentrated in the liver and kidneys and is thus especially depleted during dialysis.
  • selenium is a powerful antioxidant and is especially useful when employed against the damaging effects of free radicals.
  • selenium supplementation may protect against hardening of the arteries and harmful molecules. Handbook of Nonprescription Drugs, 1 1 th edition, 1996, American Pharmaceutical Association. 2215 Constitution Avenue, NW, Washington, DC 20037. Chapter 19, Nutritional Products, page 387.
  • the selenium is provided as an ionic compound of selenium such as, for example, sodium selenate.
  • the formulations described herein include an ionic compound of selenium in an amount such that there is 10 ⁇ 9 to 400 ⁇ 9, 10 ⁇ to 300 ⁇ 9, 10 Mg to 200 ⁇ 9, 10 ⁇ 9 to 100 ⁇ 9, or 25 ⁇ 9 to 80 ⁇ 9 of selenium per unit dose.
  • the formulations disclosed herein include a pharmaceutically-acceptable compound of iron.
  • iron is vital in preventing anemia. Handbook of Nonprescription Drugs, 1 1 th edition, 1996, American Pharmaceutical Association. 2215 Constitution Avenue, NW, Washington, DC 20037. Chapter 19, Nutritional Products, page 380.
  • biochemically iron is important to oxygen and electron transport as well as prevent anemia and improve the quality and quantity of red blood cells.
  • heme iron is found in meats and is well-absorbed, while non- heme iron is poorly absorbed.
  • supplementation of iron may be particularly important for patients consuming diets that include little or no meat.
  • the iron is provided as an ionic compound of iron such as, for example, iron gluconate, iron gluconate dihydrate, or iron sulfate heptahydrate.
  • the formulations described herein include an ionic compound of iron in an amount such that there is 1 mg to 45 mg, 1 mg to 30 mg, 1 mg to 20 mg, or 5 mg to 20 mg of iron per unit dose.
  • the formulations disclosed herein incorporate one or more amino acids.
  • these amino acids can be proteinogenic or non- proteinogenic.
  • L-carnitine is a vitamin-like molecule that is used by the body to transport fatty acids into the mitochondria for breakdown. It is a non-proteinogenic amino acid that is synthesized in the liver and kidneys from lysine and methionine. This essential amino acid is completely or almost completely depleted from the blood with chronic kidney dialysis. L-carnitine deficiency has been linked to adverse cardiac conditions including, but not limited to, arrhythmias and angina; thus, in one aspect, supplementing with L-carnitine can reduce the incidence of cardiac damage and cardiac events associated with kidney dialysis.
  • L- carnitine deficiency has been shown to limit mitochondrial fat metabolism in the heart and other organs; in this aspect, supplementation with L-carnitine may help restore normal mitochondrial fat metabolism.
  • L-carnitine supplementation can provide support in cases of muscle weakness and may protect against circulatory disorders.
  • L-carnitine has been shown to be important in oxidation of fatty acids and cellular energy management.
  • the formulations disclosed herein include pharmaceutically- acceptable compound of L-carnitine.
  • pharmaceutically-acceptable compounds of L-carnitine include, but are not limited to, acetyl-L-carnitine or L- carnitine-L-tartrate, which can be metabolized in the blood by plasma esterases to produce L-carnitine.
  • L-carnitine can be used directly.
  • the amount of the pharmaceutically-acceptable compound of L-carnitine present per unit dose is from 100 mg to 3,500 mg, 500 mg to 2,500 mg, 500 mg to 1 ,000 mg, 1 ,000 mg to 2,000 mg of L-carnitine per unit dose.
  • L-carnitine-L-tartrate will provide 1 ,500 mg of L-carnitine per unit dose.
  • 500 mg to 2,500 mg of acetyl-L-carnitine or L-carnitine-L-tartrate is included in the supplements disclosed herein.
  • additional ingredients can be included in the supplements disclosed herein.
  • the formulations disclosed herein include citrus bioflavonoids.
  • citrus fruits are excellent sources of vitamin C and citrus bioflavonoid preparations sourced from whole citrus fruits or citrus rinds/peels or pith may be rich in vitamin C.
  • the citrus bioflavonoids can be from lemons, limes, grapefruits, oranges, tangerines, or a combination thereof.
  • the citrus bioflavonoids can include rutin, quercetin, tangeritin, diosmetin, diosmin, naringin, nairrutin, neohesperidin, nobiletin, hesperidin, and combinations thereof.
  • citrus bioflavonoids may be anti-inflammatory, antioxidant, or anti-microbial.
  • citrus bioflavonoids may improve capillary permeability and circulation, hypertension, swelling or edema, and insulin response, or a combination thereof.
  • sources of citrus bioflavonoids may contain flavor compounds that render the compositions disclosed herein more palatable.
  • the formulations disclosed herein include powdered extracts of cranberry and cherry.
  • cranberry and cherry extracts may contain flavor compounds that render the compositions disclosed herein more palatable.
  • cranberry and cherry extracts are high in antioxidants, vitamins, and minerals.
  • cranberry extract contains D-mannose, a sugar that has anti-biofilm (bacterial biofilm that is) properties, binds to and agglomerates bacteria in the urinary tract, thus helping to prevent urinary tract infections, which can be especially important for dialysis patients.
  • the cherry extract is from tart cherry. Further in this aspect, consumption of tart cherry extract may reduce side effects of statins, may improve blood cholesterol levels, may reduce inflammation related to arthritis and/or obesity, and may support a healthy metabolism.
  • some minerals are not to be included in the supplements disclosed herein.
  • potassium is excluded from the formulations described herein.
  • high potassium levels can cause muscle and heart problems.
  • potassium levels can rise between dialysis sessions and may affect the heartbeat.
  • the formulations disclosed herein exclude sodium.
  • increased sodium consumption causes thirst and may lead to water retention.
  • excess sodium consumption and/or high sodium levels can raise the blood pressure. Phosphorus
  • the formulations disclosed herein exclude phosphorus.
  • too much phosphorus in the blood can cause calcium resorption from the bones.
  • too much phosphorus can cause the skin to itch.
  • a phosphate binder is provided to the patient alongside the formulations disclosed herein.
  • the supplements described herein can be formulated using techniques known in the art.
  • the minerals, vitamins, and amino acids supplied in dry form are admixed with one another to produce a dry powder.
  • other pharmaceutically-acceptable fillers can be added to formulate the supplement in powder form.
  • polysaccharides such as, for example, maltodextrin, can be used to formulate the supplement.
  • the supplement is a unit dose composition composed of
  • the supplement includes the following components in a dry powder:
  • vitamin B2 in the amount of 0.1 mg to 2 mg per unit dose
  • vitamin B3 in the amount of 1 mg to 40 mg per unit dose
  • vitamin B5 in the amount of 1 mg to 20 mg per unit dose
  • vitamin B6 in the amount of 1 mg to 100 mg per unit dose
  • vitamin C in the amount of 10 mg to 2,000 mg per unit dose
  • vitamin D 3 in the amount of 1 ⁇ g to 100 ⁇ g per unit dose
  • the supplement includes the following components in a dry powder:
  • vitamin B2 in the amount of 0.5 mg to 2 mg per unit dose
  • vitamin B3 in the amount of 1 mg to 20 mg per unit dose
  • vitamin B5 in the amount of 1 mg to 15 mg per unit dose
  • vitamin B6 in the amount of 1 mg to 10 mg per unit dose
  • vitamin B7 in the amount of 10 g to 100 ⁇ g per unit dose
  • vitamin C in the amount of 100 mg to 300 mg per unit dose
  • vitamin D 3 in the amount of 1 ⁇ g to 20 ⁇ g per unit dose
  • the supplement has the following components as provided in Table 1 .
  • Marine Algal Oil, EPA:DHA ratio is from 1 : 1 to 4: 1 .
  • L-Carnitine 1500 mg Acetyl-L-Carnitine or
  • Extract of Cranberry and Cherry (optional) Extract of Dried, Powdered
  • the supplements described herein are intended to be taken orally.
  • the supplements can be formulated as tablets or capsules.
  • the supplements can be formulated as a powder that can be mixed with water or another beverage.
  • the powder form of the supplement can be admixed with food such as yogurt, peanut butter, or other foods that readily mix with the supplement.
  • the formulations described herein are to be administered to patients with kidney disease and/or undergoing kidney dialysis, or individuals at risk of kidney diseases (lifestyle, family history, etc.).
  • the amount of formulation administered to the patient should not exceed the recommended daily dose for each component.
  • the formulations can be administered to the patient prior to dialysis, during dialysis, after dialysis, and any combination thereof.
  • the nutritional supplement described herein is designed to support kidney and cardiac function as well as mitochondrial energy function needs in patients undergoing hemodialysis. This supplement replenishes essential vitamins and minerals that are lost during dialysis, does not contain compounds that may specifically cause harm to dialysis patients, and provides support for tissues undergoing oxidative stress. By replenishing the minerals and vitamins lost during dialysis, the subject will have increased energy levels that will permit the subject to lead a more productive life.
  • Omega 3 fatty acids are lipid soluble macronutrients that are important to metabolism (i.e., energy production captured in the form of ATP). Omega 3 fatty acids are partially removed from the body with chronic kidney dialysis. Omega 3 fatty acids have been shown to reduce inflammation and thus to lower the risk of chronic diseases (including heart disease). They are believed to be important for cognitive function and also have been shown to reduce triglycerides while increasing high-density lipoproteins (HDL) cholesterol. Omega 3 fatty acids have been linked to improvement in a number of other conditions including from skin, joint, eye, and gastrointestinal conditions.
  • HDL high-density lipoproteins
  • supplementation with omega 3 fatty acids can be especially important for improving blood pressure, blood circulation, and blood vessel elasticity while preventing cardiovascular and coronary events in persons with high cardiovascular risk.
  • Marine Omega 3 Fatty Acids https://en.wikipedia.org/wiki/Fatty acid metabolism
  • Omega 3 fatty acids are found in fish, some plants, nut oils, and algae, and are not always consumed in high enough amounts through the standard diet. In one aspect, it is important to replenish the body's supply of omega 3 fatty acids, since these important macronutrients cannot be synthesized by the body.
  • marine omega 3 fatty acids i.e., from fish or algae
  • DHA docosahexaenoic acid
  • EPA eicosapentaenoic acid
  • omega 3 fatty acids from plant sources which primarily contain ALA (alpha linolenic acid), a compound that is not efficiently utilized by the body.
  • the formulations disclosed herein include marine omega 3 fatty acids.
  • the marine omega 3 fatty acids can be sourced from salmon, mackerel, sardines, tuna, or herring. Many Western diets incorporate higher dietary omega 6 fatty acids, which can promote inflammation.
  • the amount of Omega 3 is significantly higher than the amount Omega 6.
  • hemodialysis is believed to upregulate oxidative mechanisms, which could lead to peroxidation of omega 3 fatty acids; this, in turn, can lead to breakdown of the fatty acid structure and loss of function.
  • supplementation with omega 3 fatty acids can be used to replenish the supply of nutrients destroyed by peroxidation.
  • the marine omega 3 fatty acids are provided as wild Alaskan salmon oil or marine algal oil.
  • the EPA:DHA ratio of the marine omega 3 fatty acids is from 1 :1 to 4: 1 .
  • the amount of marine omega 3 fatty acids present per unit dose is from 500 mg to 4,000 mg, 500 mg to 3,000 mg, 500 mg to 2,000 mg, or 500 mg to 1 ,500 mg.
  • 1000 mg of marine omega 3 fatty acids are provided per unit dose of the supplements disclosed herein.
  • coenzyme Q10 can be taken with the supplements described herein.
  • CoQ10 acts as an antioxidant and protects the cell membrane against oxidative stress.
  • CoQ10 is an important coenzyme in the mitochondria (and other parts of the cell) and participates in cellular respiration, which ultimately generates energy in the form of adenosine triphosphate.
  • CoQ10 protects against low-density lipoproteins (LDL) oxidation, which is vital for heart health.
  • reduced form of CoQ10 (CoQ10H 2 ) can regenerate vitamin E from the alpha- tocopheroxyl radical, thus leading to a reduction of oxidative stress.
  • certain patients require intake of CoQ10 that is higher than provided by the average diet.
  • These include, but are not limited to, athletes, patients with hyperthyroidism, patients who are taking statins, and the elderly.
  • elderly dialysis patients may especially benefit from CoQ10 supplementation.
  • CoQ10 can decrease insulin requirements in patients with diabetes; thus, diabetic dialysis patients may also benefit from CoQ10 supplementation.
  • CoQ10 supplementation should be avoided in patients taking warfarin or other blood thinners, as it can reduce the activity of these medications.
  • the supplements disclosed herein do not include CoQ10.
  • CoQ10 in the supplements disclosed herein is provided as ubiquinol, a reduced form of CoQ10 that has a particularly high uptake percentage and subsequently leads to an increase of CoQ10 levels in the blood.
  • Ubiquinol effectively regenerates vitamin E from alpha-tocopherol radical.
  • the amount of CoQ10H 2 (e.g., ubiquinol) present per unit dose is from 70 mg to 400 mg, 70 mg to 300 mg, or 150 mg to 250 mg.
  • 200 mg of ubiquinol are included in the supplements disclosed herein.
  • turmeric can be taken with the supplements described herein.
  • Turmeric has anti-inflammatory and antioxidant properties that are in some aspects useful to the kidneys.
  • the formulations disclosed herein do not include turmeric.
  • turmeric should not be given to patients who are sensitive or allergic, pregnant or nursing, diabetic and taking blood thinners, patients with gall bladder conditions, and/or patients with digestive system disorders such as GERD (gastroesophageal reflux disease).
  • GERD gastroesophageal reflux disease
  • turmeric is prepared in a separate distribution form (e.g., a separate capsule) and given to patients at their healthcare providers' discretion.
  • turmeric is provided with the supplement unless the patient is going to undergo surgery and/or has a bleeding disorder, since turmeric is known to be a powerful blood thinner.
  • pepperine can be taken with the supplements described herein.
  • turmeric is not easily absorbed by the body and pepperine enhances absorption by 10 to 20 fold.
  • the formulations disclosed herein include 100 mg of pepperine for every 500 mg of turmeric.
  • the amount of turmeric present per unit dose is from 1 g to 3g, 1 .5 g to 2.5 g, or 2 g.
  • the supplements is formulated as a kit, where one compartment or vial has a mixture of the supplement described herein composed of the minerals, vitamins, and amino acids supplied in dry form (e.g., tablet, powder), and a second compartment of containing other supplements (e.g., marine omega 3 fatty acids in capsule form, ubiquinol in gel form, turmeric is in a capsule, or any combination thereof).
  • dry form e.g., tablet, powder
  • other supplements e.g., marine omega 3 fatty acids in capsule form, ubiquinol in gel form, turmeric is in a capsule, or any combination thereof.
  • reaction conditions e.g., component concentrations, desired solvents, solvent mixtures, temperatures, pressures and other reaction ranges and conditions that can be used to optimize the product purity and yield obtained from the described process. Only reasonable and routine experimentation will be required to optimize such process conditions.
  • a supplement described herein was evaluated with a subject undergoing dialysis.
  • the subject has been treated for dialysis for the last 20 years and for the last 13 years at his home. Dialysis is conducted at home every other night for 7 hours.
  • the subject initially started taking a full dose of the supplements (8.5 g of the supplement provided in Table 2). However, the doze of the supplement was adjusted to a half dose. The subject took a quarter of the supplement together with fast carbohydrates for breakfast and the same dose for lunch with fast carbohydrates.
  • the subject's mental condition improved.
  • the subject did not need to sleep so much as before.
  • the subject has more energy and is able to do more activities such as play golf.
  • the subject After taking the supplement for about six weeks, the subject has more energy and able to perform more outdoor activities (e.g., play 18 holes of golf). The subject perspires much more compared to when he was not taking the supplement, which is positive for dialysis patients that have problems getting rid of excess liquid in their body. The subject is also sleeping very well and is more focused. The subject's blood pressure is good. Renal blood samples are also good except for the level of sodium, which has been adjusted due to dialysis treatment.

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Abstract

La présente invention concerne un complément nutritionnel conçu pour prendre en charge les besoins des fonctions rénale et cardiaque, ainsi que de la fonction d'énergie mitochondriale chez des patients subissant une hémodialyse. Ce complément réapprovisionne le corps en vitamines et minéraux essentiels qui sont perdus pendant la dialyse, ne contient pas de composés qui peuvent être particulièrement nocifs pour les patients subissant une dialyse, et permet de supporter les tissus subissant un stress oxydatif.
PCT/US2017/048126 2016-08-26 2017-08-23 Complément alimentaire macro/micronutritionnel pour patients subissant une dialyse rénale WO2018039297A1 (fr)

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US16/326,250 US11077085B2 (en) 2016-08-26 2017-08-23 Dietary macro/micronutritional supplement for patients undergoing kidney dialysis
EP17844320.6A EP3503745B1 (fr) 2016-08-26 2017-08-23 Complément alimentaire macro/micronutritionnel pour patients subissant une dialyse rénale
JP2019531865A JP7012724B2 (ja) 2016-08-26 2017-08-23 腎臓透析を受けている患者のための食餌性多量/微量栄養補給剤
US17/389,719 US20210353578A1 (en) 2016-08-26 2021-07-30 Dietary macro/micronutritional supplement for patients undergoing kidney dialysis

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WO2019165222A1 (fr) * 2018-02-23 2019-08-29 Dabdoub Atif Complément alimentaire macro/micronutritionnel et applications associées
US11077085B2 (en) 2016-08-26 2021-08-03 Atif Dabdoub Dietary macro/micronutritional supplement for patients undergoing kidney dialysis

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11077085B2 (en) 2016-08-26 2021-08-03 Atif Dabdoub Dietary macro/micronutritional supplement for patients undergoing kidney dialysis
WO2019165222A1 (fr) * 2018-02-23 2019-08-29 Dabdoub Atif Complément alimentaire macro/micronutritionnel et applications associées

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