WO2018035628A1

WO2018035628A1 - Laboratory rodent holder

Info

Publication number: WO2018035628A1
Application number: PCT/CN2016/096121
Authority: WO
Inventors: Tian LI; 孙建军; 孔祥君; 李志新; 高嵩
Original assignee: 北京聚精瑞生医疗科技有限公司
Priority date: 2016-08-21
Filing date: 2016-08-21
Publication date: 2018-03-01
Also published as: EP3501451A4; EP3501451C0; EP3501451B1; EP3501451A1

Abstract

The present invention relates to biomedical experiment equipment, and particularly relates to a laboratory rodent holder. The rodent holder employs shape-modeling wire frames and multiple adjustment components for varying the positions of the shape-modeling wire frames, or is provided with wire frames for different rodent shapes. The rodent holder comprises a frame body (7) of a rod frame structure. The present invention enables adaptation to various rodent shapes and sizes, facilitates operation, and provides a large exposed body portion of a wake laboratory rodent in a laboratory environment, thus being suitable for multiple types of rodent experiments. Additional components providing support in a reverse direction increase flexibility during use. The present invention provides potentially operable locations nearly over the entire body surface of a rodent. A support plane or support horizontal rod (22) provides support to a rodent before and after an experiment, and is easy to assemble or disassemble. Furthermore, a magnifier (5) placed at a tail holding portion improves a visual environment for operations. The holder of the present invention provides operational convenience during the entirety of an experiment process on a rodent, has a simple and unique structure, and facilitates manufacturing, assembly, and use thereof.

Description

Experimental mouse retainer

[0001] The present invention belongs to animal experimental equipment in the medical or biological field, and mainly relates to improvement of experimental mouse fixation equipment.

Background technique

[0002] The experimental mouse fixation device is a necessary equipment for the experimental activities of the awakening mouse as an experimental animal, and a variety of structural products or solutions have been introduced, and the donor and the user select and use, which provides convenience for the experiment. Existing equipment or solutions are mostly fixed in a substantially closed container by controlling the range of motion of the mouse in the head and tail directions. Thus, although the fixed range is reliable, the mouse body itself is not completely fixed; and the substantially closed container allows the experimental mouse body to be almost completely covered, which limits the operation of the mouse body. In the case where the mouse body is reliably fixed, there is also a problem that the exposed portion of the mouse is less, which affects the experimental operation of the experimental mouse, such as subcutaneous, abdominal cavity, and tail vein injection.

technical problem

[0003] It is an object of the present invention to provide an experimental mouse retainer having a larger exposed area of the mouse and a fixed fixation to accommodate the operational needs of a wider range of experimental mice. The technical problem to be solved is to propose a technical solution having such a performance experimental mouse holder.

Problem solution

Technical solution

[0004] The specific content of the present invention is an experimental mouse holder comprising a frame body, a fixing member associated with the frame body, restricting the movement of the mouse body, and a coupling member connecting the frame body and the fixing member. Wherein, the fixing component is a grille required to fix the mouse body in a clamping manner, imitating or approximately resembling the outer shape of the corresponding position, and the coupling component further comprises an adjusting component capable of changing the position of the grille.

[0005] A grille that resembles or resembles a shape of a mouse body shape is used to ensure a conformity or a basic fit of each grille and a corresponding portion of the mouse body. Adjusting the position of the grille is required for the grid clamping and releasing the rat body to adapt to the difference of the specific experimental mouse body, stably and reliably restrict the activities of different mouse bodies, and suitable for releasing the mouse body that has completed the experimental operation; Moreover, fixing the experimental rat with a grid-shaped member can also significantly reduce Covering the mouse body exposes more mouse parts, allowing the device to provide superior experimental operating conditions. The object of the present invention is thus achieved, and the technical problems raised by the object of the invention are solved.

The object of the present invention can also be further achieved by the following scheme.

[0007] The adjusting component of the present invention comprises a sliding screw pair that changes the relative positional relationship between the position of the grille or the grille, the relative position of the fixed coupler, the screw drive pair or the opposite direction of the thread, and the change of the single A ratchet ratchet coupling pair at a relative position between different parts of the root grid.

[0008] The sliding pair, the screw drive pair or the ratchet ratchet coupling pair are all coupling pairs that can change the relative position between the connected components, that is, the relative position between the fixed pair and the movable member in the sliding pair can be changed, and the change The relative position between the main and passive components in the transmission pair, or the relative position between the ratchet and the ratchet can be changed; and the relative positions between the couplings can be fixed, so that the two sliding parts are fixed to each other at a new relative position. Due to the structural characteristics of the thread pair and the ratchet ratchet coupling pair, the two mating couples can be relatively fixed after adjustment; the compound screw drive has two opposite passive parts in the transmission due to the opposite thread direction. The relative motion of the opposite or opposite direction has a higher fluctuation adjustment efficiency in the same position where the relative position can be changed and fixed.

[0009] The present invention is provided below the grille with a supporting plane which is connected with the frame body for the experimental mouse to step into the clamped position; or is provided with the lower end of each pole of the grille for the experimental mouse step The support rail into the clamped position. Both the flat and the crossbars can be used as experimental rats to provide support for stepping in and out of the clamped position, allowing the rats to enter and exit the experimental mouse holder before and after being clamped.

[0010] The frame body of the present invention is a rod frame structure, and a reverse support attachment associated with the activity is also provided. The frame structure is a frame structure, which can leave more space and provide more convenience for the experimental designer. Originally used as a support frame for the support frame, the support of the grille and the like is maintained under the action of the reverse support attachment, and the state of being supported in the opposite direction is reversed. The abdomen of the mouse body held by the grille can be placed face up, which provides convenience for the experimenter; the reverse support of the movable joint facilitates the conversion between the support and the counter support, facilitating the experiment with the need , added options for operation, and easy to store and store.

[0011] The rear end section of the frame body is provided with a bracket that is movablely coupled with the front and rear sides of the frame body and the height of the clamping body, and the bracket is provided with a belt for placing the rat tail. a flat plate with a groove, an illumination heating source under the trough, a magnifying glass on the trough, and a magnifying glass and a bracket to fix the phase in an adjustable relative position Union.

[0012] The stent belongs to the extension of the rat body, that is, the fixation of the rat tail. The slotted groove can pass through the light under the groove, heat the blood vessels, and heat the rat tail for easy operation. A magnifying glass on the slot improves the operator's visual environment. The active fit between the bracket and the frame in both directions can adjust the relative position between the two to accommodate the needs of different mouse experiments.

Advantageous effects of the invention

Beneficial effect

[0013] The present invention utilizes a contoured grille, various types of adjustment components for changing the position of the grille, support planes and crossbars, frame bodies of the frame structure and movable reverse supports, and can be equipped with grills of different mouse bodies. In addition to being more convenient to fix the mouse outside, it can also adapt to various body shapes and easy to operate. It can leave a large area of mouse exposure in the same body of the fixed mouse body, adapting to various mouse experimental contents; The accessories further increase the flexibility of the device, so that the ventral side of the mouse body may be in a convenient position; the magnifying glass placed on the tail of the rat improves the visual environment of the operation; it can bring operation to the full range of experimental contents of the mouse body. It's easy to make, easy to manufacture, install and use.

Brief description of the drawing

DRAWINGS

1 is a schematic structural view of an experimental mouse holder;

Figure 2 is a left side view of Figure 1;

Figure 3 is a plan view of Figure 1;

4 is a strut

Figure 5 is a plan view of Figure 4

[0019] FIG. 6 is a reverse support view of the rat tail fixing member such as the post plate removed;

Figure 7 is a left side view of Figure 6;

[0021] FIG. 8 is a schematic view showing the structure of a sliding sleeve with a taper sleeve;

[0022] FIG. 9 is a partial view of an experimental mouse holder with a support crossbar;

[0023] FIG. 10 is an experimental rat retainer supported by an adjustable height strut.

[0024] The meaning of the lead number represented in the figure: 1 sliding pair 2 beam 3 claw rod 4 column 5 magnifying glass 6 plate 7 frame 8 hinged 9 pillar 10 connecting rod 11 bidirectional screw 12 limit sliding pair 13 nut 14 slit 15 rocker 16 struts 17 Casing 18 claw 19 chord 20 taper sleeve 21 cone 22 crossbar.

BEST MODE FOR CARRYING OUT THE INVENTION

[0025] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

The first embodiment is an experimental mouse holder with a strut, see Fig. 1 to Fig. 5.

[0027] The frame body 7 of the present example is a "dry" shaped rod frame on a horizontal plane, and is arranged on both sides of the vertical bar as a "dry" word on the two horizontal bars of the frame body, and is provided with Each of the cross bars is respectively connected with a total of four vertical struts 9 coupled by a sliding pair 1 axially slidable along the crossbar, and connected to each other by a connecting rod 10 between the moving parts of the two sliding pairs on the same side of the vertical bar The middle section of each of the connecting rods is respectively provided with a transmission nut 13 having a reverse thread direction and an axis parallel to the crossbar. A two-way screw 11 is arranged between the two cross bars, and two screws are arranged in the opposite direction and matched with the corresponding transmission nuts. Between the two threads of the screw, the sliding pair 12 and the frame are limited in the axial direction of the screw. The vertical rods of the body are connected, and a rocker 15 for rotating the screw around the screw axis is fixed at one end of the screw in a direction perpendicular to the axial direction of the screw.

[0028] The upper ends of the two pillars on both sides of the vertical rod are respectively rigidly and fixedly coupled with the beam 2 which is contoured at the corresponding portion of the mouse body standing in the plane position of the frame body. At different positions along the length of each beam, respectively, a plurality of claw rods 3 respectively contoured with the parallel frame rails and located in a vertical plane and contoured with the corresponding portions of the mouse body, and the claw rods coupled between the two beams The locations correspond to each other. In order to adapt to different mouse bodies, a combination of various pillars, beams and claws can be provided. In order to improve the effect of the clamping and fixing, it is also possible to apply a flexible material to the inner surface of each group, or directly to prepare the beam and the claw rod of each combination with a material that is less irritating to the mouse body.

[0029] The rear half of the frame vertical rod is relatively fixed at the root end of the rat tail, and the detachable sliding pair axially oriented in the longitudinal direction of the vertical rod is slidably associated with the vertical rod, and the vertical column 4 in the vertical direction is The sliding pair is fixedly coupled, and the column separates two struts which can contact the supporting plane of the frame on both sides of the vertical rod. The column is provided with a sliding pair whose axial direction is the longitudinal direction of the column and has a fixed axial position of the top wire, and the sliding pair is fixedly connected with the rat tail plate 6 in the direction of the horizontal plane extending to the rear of the vertical rod. In the middle of the upper surface of the rat tail plate, there is a slit 14 extending along the longitudinal direction of the frame vertical rod and having a width smaller than the radial dimension of the rat tail; a magnifying glass 5 fixed on the rat tail plate is arranged above the slit, and heat is arranged under the flat plate. light source.

[0030] The detachable limit hinge 8 is axially arranged in the horizontal plane and perpendicular to the longitudinal direction of the vertical rod, and the vertical hinge is divided into two parts. Rods are connected to each other; here A detachable chord 19 defining the two portions in a right angle coupling relationship is also provided between the two portions. The length of the rear half of the vertical rod is slightly larger than the distance from the top end of the longest claw to the support plane of the frame. Further, two struts 16 having the same length as the rear half are provided as an attachment of the embodiment, and one end of the struts is a sleeve 17 which can be sleeved with the cross member of the frame body, and the axis of the tube is perpendicular to the longitudinal direction of the struts; The other ends of the rods are respectively hingedly connected to the three rods 18 which can be divided into three points. As shown in Figure 4 and Figure 5. This concludes the description of the main structural contents of this example.

[0031] Working 吋, selecting the pillars, beams and claw rods suitable for the body shape of the experimental mouse to assemble, the experimental rats enter the grid of the example along the plane of the bottom surface of the support frame body, and the combination of the pillars, beams and claws on both sides During the rotation, the rocker of the two-way screw is rotated, and the two pillars, the beam and the claw rod are arranged to face each other through the connecting rod until the experimental mouse is clamped and fixed, and the experimental operation can be performed.

[0032] If the operation part of the experimental content is on the back of the mouse, such as subcutaneous injection, the operation space required for the experiment of the fixed back of the mouse body can be provided for the experiment because a large gap remains between the grill claws on the back side. . If the experimental content involves the abdominal part of the mouse, such as intraperitoneal injection, fold the rear hinge part of the vertical rod of the frame body, and connect the chord between the two parts of the vertical rod that is folded at right angles, and the cross rod at the head end of the frame body The end sleeve is sleeved with the sleeve of the end of the accessory strut, and the device of the example is turned over, so that the strut and the lower end of the rear half of the vertical rod of the frame are supported by the lower support end of the original frame body, and the experimental mouse has been clamped and fixed. The sputum is presented in the experimental environment in a supine posture, and the experimenter can perform corresponding operations.

[0033] If the experimental part of the experimental mouse is in the tail of the mouse, such as the tail vein injection, the rat tail plate and the column are mounted on the frame before the experiment, after the experimental mouse is fixed, the column is moved, and the rat tail plate is placed in the experiment. In the proper position of the rat tail, the mouse tail is placed on the gap of the rat tail plate to turn on the LED light source, the magnifying glass is placed in the working position, the tail vein is fluoroscopy and the blood is injected or collected. After the experiment is completed, the rocker is reversely rotated to release the fixation of the experimental mouse, and the initial working state of the fixture is restored. The experimental mouse can resume the state of standing on the plane supporting the bottom surface of the frame body, and the experiment is withdrawn.

[0034] The grill-type fixing component provides an all-round fixed state for the experimental mouse body; the hinged connection of the accessory strut and the rear of the vertical rod enables the device to have both positive and negative support states; the configuration of the magnifying glass improves the experimenter The visual effect; it can bring the operation convenience to the all-round experimental content of the mouse body, and the structure of the device is simple and unique, and it is convenient to manufacture, install and use.

[0035] The outstanding technical features of this example are: 1. Multi-purpose and flexible, three-dimensional adjustment, detachable, the grille and the frame are freely coupled, the structure is simple, and the operation is convenient; 2. The grille fixes the mouse body, and the mouse head is closed. Can avoid being bitten by rats , and the fixation effect is good, the damage to the mouse is small; 3. The grille can be slidable and detachable, and can be used for fixing the rat and fixing the mouse; 4. The relative height of the rat tail plate can be adjusted according to the size of the mouse hip. Ensure the horizontal position of the rat tail, easy to operate; 5. The rat tail flat lighting seam is designed according to the physiological shape of the rat tail, and help to identify the tail vein through illumination and amplification, improve the puncture success rate; 6. LED lighting energy saving and detachable, easy The device is cleaned and disinfected; 7. The structure of the device is simple and reasonable, and it is easy to operate.

[0036] The second embodiment is an experimental mouse holder that can fix a sliding pair.

[0037] This example is basically the same as the previous example, except that the connection between the column and the frame is a sliding pair with a fixed structure.

When the working position 需要 needs to be selected, the fixed structure releases the sliding gap between the sliding parts. After selecting the appropriate position, the fixing structure eliminates the gap between the sliding parts and gives a certain pressure to maintain the fixed state, keeping the experiment The working position required for the clamping or experiment of the mouse. The structure may be such that the two sliding members are provided with movable members that can be ejected, and need to be pressed and pressed in, and need to be fixed in mutual position. It can also be a structure with a set screw on the sliding part, move the 吋 release screw, and fix the 吋 screw.

[0038] In the third embodiment, a coupling pair with a ratchet ratchet is provided in the middle of each claw rod, and the matching relationship between the ratchet ratchet teeth is changed, the shape of the claw rod bending can be changed, and the restriction relationship between the ratchet ratchet teeth is released. , can restore the shape of the claw before the change. Thereby functioning to adjust the contour shape of the claw rod. The rest of the situation is the same as the previous example.

[0039] In the fourth embodiment, a through groove may be formed on the cross bar to fix the relative position between the strut and the cross bar by bolts to fix different positions between the strut and the through groove. The other cases in this example are consistent with the previous example.

[0040] The fifth embodiment is an experimental mouse holder with three struts. In this example, the rear half of the vertical rod of the frame does not have a hinge pair, and the third struts are also sleeved on the frame like the two struts of the previous example. The end of the vertical rod at the rear allows for reverse support of the device. Other cases are consistent with the above embodiments.

[0041] A sixth embodiment is an experimental mouse holder with a tapered mating sliding pair, see FIG. The cone core 21 is slidably engaged with the frame rail or the beam, and the tapered tube body of the first half of the cone core is formed into a tapered lobed shape in the axial direction and a discontinuous cone shape in the circumferential direction, and the tapered half tube and the taper sleeve of the second half of the cone core Threaded, the inner hole of the first half of the taper sleeve is a tapered hole that cooperates with the front half of the cone core. When the taper taper sleeve is 20吋, the taper hole is separated from the cone core, and the cone core can slide freely on the crossbar or beam; After entering the taper sleeve, the taper sleeve is close to the cone core until the gap between the cones is reduced by the sliding between the cone surfaces, and the taper hole of the cone core is also reduced, after the sliding gap between the cone core and the crossbar is eliminated, Further spin A tight taper sleeve secures the relative position between the cone core and the crossbar. In this case, the relative position between the strut and the crossbar fixed to the taper sleeve is fixed. In the opposite operation, the active coupling state between the strut and the crossbar can be restored, the clamping of the rat body can be released, or the relative position between the strut and the crossbar can be adjusted.

[0042] The seventh embodiment is an experimental mouse body holder provided with a gusset. In this example, a flat gusset having a gutter is added to the frame, and the gutter is corresponding to the position of the struts between the frame and the beam. Using 吋, inserting the struts into the struts and covering them on the frame body, as the supporting plane for the experimental initial placement of the experimental rats, after the grips are clamped, the struts are removed, which can provide a flatter mouse body for the experiment. In and out of the channel. Other structures and usages are consistent with the above examples.

[0043] The eighth embodiment is an experimental mouse holder provided with a support rail grille, as shown in the drawing. In this example, the positions of the grids on the opposite sides are mutually staggered, and under the grid, there are provided support rails 22 which are associated with each grid and which are laterally oppositely extended at a height suitable for the stepping of the experimental rat until they are in the lateral position. Begin to overlap. A plurality of crossbars constitute a support point for the rats to step on, providing the experimental rats with a support channel for accessing the grille. Other structures and working conditions are consistent with each case.

[0044] The ninth embodiment is an experimental mouse holder provided with an adjustable height stay, see FIG. In this example, a plurality of struts of adjustable height are provided, and the struts can be associated with the movement of the frame. The truss body is supported by the struts, and the height of the struts at different positions can be adjusted according to the needs of the experimental part, so that the sides of the mouse body that have been clamped and fixed by the grille may be located above the clamped state. Or close to the position above it. Provide conditions for experiments that require this. Other structures and work conditions are consistent with the above examples.

Claims

Claim

[Claim 1] An experimental mouse holder, comprising a frame body, a fixing member associated with the frame body, restricting movement of the mouse body, and a coupling member connecting the frame body and the fixing member; wherein: the fixing member is imitation or approximate a grille of a rat-like shape, the coupling member further comprising an adjusting member capable of changing the position of the grille, and the experimental mouse retainer according to claim 1, wherein: the adjusting member for changing the position of the grille comprises a sliding pair, A threaded drive pair or a multiple-screw drive pair with the opposite direction of the thread changes the ratchet ratchet coupling of the relative position between different parts of the single grid.

The experimental mouse retainer according to claim 1 or 2, wherein: a support plane connected to the frame body for the experimental mouse to enter the clamped position is provided under the grille; or The lower ends of the bars are connected to each other, and the test rods can be used to step into the clamped position of the clamped position.

The experimental mouse retainer according to claim 1 or 2, wherein: the frame body is a rod frame structure, and a reverse support attachment associated with the frame body movement is further provided.

The experimental mouse retainer according to claim 3, wherein: the frame body is a rod frame structure, and a reverse support attachment associated with the frame body movement is further provided.

The experimental mouse retainer according to claim 1, 2 or 5, wherein: at the rear end section of the frame body, there are two movement directions of the front and rear and the height of the clamping along the grille. The bracket is provided with a flat plate on which the rat tail is grooved, a lighting heating source is arranged under the flat groove, and a magnifying glass is arranged on the groove, and the magnifying glass and the bracket are fixedly connected by the adjustable relative position.

The experimental mouse retainer according to claim 3, wherein: at the rear end section of the frame body, a bracket is provided which is associated with the height of the front and rear and the height of the clamp which are clamped along the grille. The bracket is provided with a flat plate with a slotted groove of the rat tail, and an illumination heating source is arranged under the flat slot, and a magnifying glass is arranged on the slot, and the magnifying glass and the bracket are fixedly connected by the adjustable relative position. The experimental mouse retainer according to claim 4, wherein: at the rear end section of the frame body, a bracket is provided which is associated with the height of the front and rear of the frame and the height of the clamp. The bracket is provided with a flat plate with a slotted groove of the rat tail, and an illumination heating source is arranged under the flat slot, and a magnifying glass is arranged on the slot, and the magnifying glass and the bracket are fixedly connected by the adjustable relative position.