WO2018034593A1 - Method of purifying milk of tetracycline group antibiotics - Google Patents

Method of purifying milk of tetracycline group antibiotics Download PDF

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Publication number
WO2018034593A1
WO2018034593A1 PCT/RU2017/000516 RU2017000516W WO2018034593A1 WO 2018034593 A1 WO2018034593 A1 WO 2018034593A1 RU 2017000516 W RU2017000516 W RU 2017000516W WO 2018034593 A1 WO2018034593 A1 WO 2018034593A1
Authority
WO
WIPO (PCT)
Prior art keywords
milk
antibiotics
tetracycline
tetracycline group
purifying
Prior art date
Application number
PCT/RU2017/000516
Other languages
French (fr)
Russian (ru)
Inventor
Ксения Андреевна МЕРЗЛЯКОВА
Original Assignee
Ксения Андреевна МЕРЗЛЯКОВА
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ксения Андреевна МЕРЗЛЯКОВА filed Critical Ксения Андреевна МЕРЗЛЯКОВА
Publication of WO2018034593A1 publication Critical patent/WO2018034593A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C7/00—Other dairy technology
    • A23C7/04—Removing unwanted substances other than lactose or milk proteins from milk
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02—Food
    • G01N33/04—Dairy products

Definitions

  • the invention relates to the dairy industry, in particular, the extraction of undesirable substances from milk, namely the purification of milk from antibiotics of the tetracycline group.
  • the tetracycline antibiotics are widely used in agriculture for the treatment of mastitis in animals, and thus get into the final product — milk.
  • the use of foods containing antibiotics of the tetracycline group can cause extremely adverse effects on human health.
  • the essence of the invention lies in the fact that milk containing tetracycline antibiotics is purified, hydrated lime (Ca (OH) 2 ) is used as a reagent, the reaction proceeds under standard conditions, as a result of the reaction, insoluble chelated calcium salts are formed, which are subsequently removed from the milk by filtration .
  • the objective of the invention is to develop a method for the purification of raw milk contaminated with antibiotics of the tetracycline group.
  • the technical result is expressed in the removal of antibiotics of the tetracycline group from milk, which will allow us to direct the entire volume of milk supplied to the milk processing plant to produce dairy products.
  • the best embodiment of the invention is that slaked lime is added to the milk, insoluble calcium chelates are formed as a result of the reaction, which are subsequently removed from the milk by filtration.
  • the invention can be widely applied in industry, since it will allow to remove tetracycline antibiotics from milk and direct the entire volume of milk supplied to milk processing enterprises to produce dairy products.

Landscapes

  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Dairy Products (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A method consists in purifying milk contaminated by antibiotics of the tetracycline group by means of adding calcium hydroxide (Са(ОН)2) to the milk. The subsequent removal of the resulting insoluble chelated calcium salts is carried out by filtration. The method makes it possible to remove tetracycline group antibiotics from milk, and to use the entire volume of milk delivered to a dairy plant for dairy product production.

Description

ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ  DESCRIPTION OF THE INVENTION TO THE PATENT
СПОСОБ ОЧИСТКИ МОЛОКА ОТ АНТИБИОТИКОВ ТЕТРАЦИКЛИНОВОИ ГРУППЫ  METHOD FOR CLEANING MILK FROM TETRACYCLINE ANTIBIOTICS
Область техники Technical field
Изобретение относится к молочной промышленности, в частности, извлечение из молока нежелательных веществ, а именно очистка молока от антибиотиков тетрациклиновой группы. The invention relates to the dairy industry, in particular, the extraction of undesirable substances from milk, namely the purification of milk from antibiotics of the tetracycline group.
Предшествующий уровень техники  State of the art
Аналог, являющийся наиболее близким к изобретению, не выявлен. An analogue that is closest to the invention has not been identified.
В настоящее время значительные объемы молока, содержащие антибиотики тетрациклиновой группы, не подлежат переработке и утилизируются.  Currently, significant volumes of milk containing tetracycline antibiotics are not recyclable and disposed of.
Антибиотики тетрациклиновой группы широко используются в сельском хозяйстве для лечения мастита у животных, таким образом попадают в конечный продукт— молоко. Использование в пищу продуктов, содержащих антибиотики тетрациклиновой группы, может вызвать крайне неблагоприятные для здоровья человека последствия.  The tetracycline antibiotics are widely used in agriculture for the treatment of mastitis in animals, and thus get into the final product — milk. The use of foods containing antibiotics of the tetracycline group can cause extremely adverse effects on human health.
Раскрытие изобретения Disclosure of invention
Сущность изобретения заключается в том, что молоко, содержащее антибиотики тетрациклиновой группы подвергают очистке, в качестве реагента используют гашеную известь (Са(ОН)2) реакция протекает в стандартных условиях, в результате реакции образуются нерастворимые хелатные соли кальция, которые впоследствии удаляются из молока фильтрованием. The essence of the invention lies in the fact that milk containing tetracycline antibiotics is purified, hydrated lime (Ca (OH) 2 ) is used as a reagent, the reaction proceeds under standard conditions, as a result of the reaction, insoluble chelated calcium salts are formed, which are subsequently removed from the milk by filtration .
Задачей изобретения является разработка способа очистки молока-сырья, загрязненного антибиотиками тетрациклиновой группы.  The objective of the invention is to develop a method for the purification of raw milk contaminated with antibiotics of the tetracycline group.
Технический результат выражается в удалении антибиотиков тетрациклиновой группы из молока, что позволит направлять весь объем поступающего на молокоперерабатывающее предприятие молока на выработку молочных продуктов.  The technical result is expressed in the removal of antibiotics of the tetracycline group from milk, which will allow us to direct the entire volume of milk supplied to the milk processing plant to produce dairy products.
Технический результат достигается тем, что в молоко вносят гашеную известь, в результате реакции образуются нерастворимые хелатные соли кальция, которые впоследствии удаляются из молока фильтрованием. Лучший вариант осуществления изобретения The technical result is achieved by the fact that slaked lime is added to the milk, as a result of the reaction insoluble calcium chelate salts are formed, which are subsequently removed from the milk by filtration. The best embodiment of the invention
Лучший вариант осуществления изобретения заключается в том, что в молоко вносят гашеную известь, в результате реакции образуются нерастворимые хелатные соли кальция, которые впоследствии удаляются из молока фильтрованием. The best embodiment of the invention is that slaked lime is added to the milk, insoluble calcium chelates are formed as a result of the reaction, which are subsequently removed from the milk by filtration.
Промышленная применимость Industrial applicability
Изобретение может быть широко применимо в промышленности, поскольку позволит удалять из молока антибиотики тетрациклиновой группы и направить весь объем поступающего на молокоперерабатывающие предприятия молока на выработку молочных продуктов. The invention can be widely applied in industry, since it will allow to remove tetracycline antibiotics from milk and direct the entire volume of milk supplied to milk processing enterprises to produce dairy products.

Claims

ФОРМУЛА ИЗОБРЕТЕНИЯ CLAIM
Способ очистки молока, содержащего антибиотики тетрациклиновой группы, включающий внесение гашеной извести (Са(ОН)2) в молоко и последующую очистку от образовавшихся нерастворимых хелатных солей кальция при помощи фильтрования. The method of purification of milk containing tetracycline antibiotics, including the introduction of slaked lime (Ca (OH) 2) in milk and subsequent purification of the resulting insoluble chelated calcium salts by filtration.
з s
PCT/RU2017/000516 2016-08-18 2017-07-12 Method of purifying milk of tetracycline group antibiotics WO2018034593A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2016133953 2016-08-18
RU2016133953A RU2666907C2 (en) 2016-08-18 2016-08-18 Method for purifying milk from antibiotics of the tetracycline group

Publications (1)

Publication Number Publication Date
WO2018034593A1 true WO2018034593A1 (en) 2018-02-22

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PCT/RU2017/000516 WO2018034593A1 (en) 2016-08-18 2017-07-12 Method of purifying milk of tetracycline group antibiotics

Country Status (2)

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RU (1) RU2666907C2 (en)
WO (1) WO2018034593A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU545591A1 (en) * 1974-05-16 1977-02-05 Всесоюзный Научно-Исследовательский Институт Генетики И Селекции Промышленных Микроорганизмов Главного Управления Микробиологической Промышленности Совета Министров Ссср Wastewater treatment method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1731772A1 (en) * 1990-04-16 1992-05-07 Пензенский филиал Всесоюзного научно-исследовательского института антибиотиков Method for isolation of tetracycline-base from the aqueous solution
CN103086577B (en) * 2013-03-01 2014-05-21 南京大学 Purification method of tetracycline wastewater

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU545591A1 (en) * 1974-05-16 1977-02-05 Всесоюзный Научно-Исследовательский Институт Генетики И Селекции Промышленных Микроорганизмов Главного Управления Микробиологической Промышленности Совета Министров Ссср Wastewater treatment method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHULIAVSKAIA O.V. ET AL.: "Modifikatsiia sposoba opredeleniia soderzhaniia ostatochnogo kolichestva antibiotikov tetratsiklinovoi gruppy v moloke metodom vysokoeffektivnoi zhidkostnoi khromotografii s mass- spektrometricheskim detektirovaniem", ZDOROVE I OKRUZHAIUSHCHAIA SREDA, 2012, pages 304 - 308 *

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RU2666907C2 (en) 2018-09-13
RU2016133953A (en) 2018-02-22

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