WO2018014343A1 - Motion control method and therapeutic device of multileaf collimator - Google Patents

Motion control method and therapeutic device of multileaf collimator Download PDF

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Publication number
WO2018014343A1
WO2018014343A1 PCT/CN2016/091062 CN2016091062W WO2018014343A1 WO 2018014343 A1 WO2018014343 A1 WO 2018014343A1 CN 2016091062 W CN2016091062 W CN 2016091062W WO 2018014343 A1 WO2018014343 A1 WO 2018014343A1
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WIPO (PCT)
Prior art keywords
tumor
blade
leaf collimator
trolley
distance
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PCT/CN2016/091062
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French (fr)
Chinese (zh)
Inventor
刘海峰
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深圳市奥沃医学新技术发展有限公司
西安大医数码技术有限公司
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Application filed by 深圳市奥沃医学新技术发展有限公司, 西安大医数码技术有限公司 filed Critical 深圳市奥沃医学新技术发展有限公司
Priority to PCT/CN2016/091062 priority Critical patent/WO2018014343A1/en
Priority to CN201680088173.0A priority patent/CN109661255A/en
Publication of WO2018014343A1 publication Critical patent/WO2018014343A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Definitions

  • the invention relates to the technical field of medical instruments, in particular to a motion control method and a treatment device for a multi-leaf collimator.
  • radiation therapy has become one of the three major methods of cancer treatment, and more and more cancer patients receive precise radiation therapy.
  • the end forming beam can pass through the region 20, which in general can be adapted to the shape of the tumor through the region 20 to achieve conformality. Radiation therapy.
  • the beam is periodically emitted
  • the driving the carriage to move within the cross section of the beam according to the direction and distance of movement of the tumor within the cross section of the beam of beam specifically includes:
  • the carriage is moved during the time the beam is turned off, such that the beam formed by the beam through the blade at the beginning of the next illumination can be focused on the tumor through the region.
  • the driving the moving of the trolley in the cross section of the beam according to the direction and distance that the tumor moves within the cross section of the beam beam comprises:
  • the cart is driven to move the moving distance in a direction of movement of the tumor.
  • an embodiment of the present invention provides a radiotherapy apparatus, including:
  • a multi-leaf collimator comprising: two blade sets disposed opposite each other, a carriage, a blade drive mechanism, and a trolley drive mechanism, the blade set including a plurality of blades, the blade set being disposed on the trolley; the blade drive mechanism Driving the blade to move; the trolley driving mechanism is configured to drive the trolley to move;
  • a respiratory monitor for acquiring a respiratory cycle signal and transmitting it to the processor
  • An image collector for acquiring a tumor image and transmitting it to the processor
  • a processor for determining a motion path of the tumor during a respiratory cycle according to a respiratory cycle signal acquired by the respiratory monitor and the image acquisition device acquiring a tumor image within the respiratory cycle, according to the image processor
  • the current image of the tumor determines the direction and distance the tumor moves within the cross-section of the beam and is sent to the cart drive mechanism.
  • the beam is periodically emitted
  • the cart drive mechanism is further configured to drive the cart to move during a time when the beam is turned off.
  • the multi-leaf collimator includes a small car, and the two blade sets are disposed on the trolley; or
  • the multi-leaf collimator includes two carts that are respectively disposed on the two carts.
  • the trolley driving mechanism comprises: a screw rod and a driver, the trolley is connected to the screw rod; and the driver is configured to drive the trolley to move along the screw rod.
  • the radiotherapy apparatus comprises a treatment head and a ring-shaped drum, the treatment head comprising the radiation source and the multi-leaf collimator;
  • the treatment head is disposed on the annular drum and is rotatable with the circumference of the annular drum, and the treatment head is movable in a radial direction of the annular drum.
  • the radiotherapy apparatus comprises a treatment head and a guide rail, the treatment head comprising the radiation source and the multi-leaf collimator;
  • the treatment head is movable along the guide rail in the axial direction of the annular drum.
  • Embodiments of the present invention provide a motion control method and a treatment apparatus for a multi-leaf collimator, the radiation therapy apparatus comprising: two blade sets disposed opposite to each other, and a trolley, the blade set including a plurality of blades, the blade group being disposed on the trolley
  • the drive mechanism includes: a blade drive mechanism and a carriage drive mechanism, wherein the blade drive mechanism is configured to drive the blade to move to form a compliant region through which the beam of rays can pass.
  • a trolley driving mechanism for driving the trolley to move; a respiratory monitor for acquiring a respiratory cycle signal; an image collector for acquiring a tumor image in the respiratory cycle; and a processor for the respiratory cycle signal and the image acquired according to the respiratory monitor
  • the collector acquires the tumor image within the respiratory cycle to determine the direction and distance the tumor moves within the cross section of the beam during the breathing cycle, and sends a drive signal to the trolley drive structure to drive the trolley to move, thereby causing the beam to pass through the blade.
  • the beam can be focused on the tumor through the area to achieve real-time tracking of the tumor.
  • FIG. 1 is a schematic view showing a treatment of a rotating treatment of a treatment device according to an embodiment of the present invention
  • FIG. 2 is a schematic view of a multi-leaf collimator fitting a tumor shape forming beam traversable region
  • FIG. 3 is a schematic diagram of a trolley according to an embodiment of the present invention.
  • FIG. 4 is a schematic diagram of a control method of a multi-leaf collimator according to an embodiment of the present invention.
  • Figure 5 is a schematic diagram of a tumor image in a respiratory cycle and a respiratory cycle
  • FIG. 6 is a schematic diagram of a driving car moving in a cross section of a beam according to an embodiment of the present invention
  • FIG. 7 is a schematic diagram showing a simplified movement of a radiation source, a multi-leaf collimator, and a tumor according to an embodiment of the present invention
  • Figure 8 is a schematic illustration of the movement of the treatment head along the guide rail.
  • An embodiment of the present invention provides a radiation therapy apparatus, as shown in FIG. 1, including a radiation source 1, a multi-leaf collimator 10, a respiratory monitor, an image collector 2, and a processor; wherein the radiation source 1 is used to emit Beam of light.
  • the multi-leaf collimator 10, as shown in FIG. 1, includes two opposite blade groups 11 and a trolley 12, wherein the two blade groups in FIG. 1 are a first blade group 11a and a second blade group 11b, respectively.
  • the first blade group 11a and the second blade group 11b are respectively disposed on the trolley 12, and the trolley may include the first trolley 12a and the second trolley 12b, and the first blade group 11a and the first The two blade groups 11b are located on the first cart 12a and the second cart 12b, respectively.
  • the multi-leaf collimator includes a cart 12, and the cart 12 may be as shown in FIG. 3.
  • the first vane set 11a and the second vane set 11b are both disposed on the cart 12, and the cart includes an upper panel 121 and a lower panel 122.
  • the upper panel 121 and the lower panel 122 are each provided with an opening in which the conformable region formed by the blade is located, and the beam formed by the beam passing through the blade can be focused on the tumor through the region.
  • the multi-leaf collimator further includes a driving mechanism including: a blade driving mechanism and a trolley driving mechanism, wherein the blade driving mechanism is used to drive the blade to move; the trolley driving mechanism is used to drive Move the car.
  • the blade driving mechanism may be an electronic and electrical structure that can move the blade in the first direction 101, and is not specifically limited in the embodiment of the present invention.
  • the trolley driving mechanism includes: a screw rod 13 and a driver (not shown), the trolley 12 is connected to the screw rod 13; and the driver is used to drive the trolley 12 to move along the screw rod 13. .
  • the driver can receive the driving signal of the processor and drive the trolley to move according to the driving signal of the processor.
  • the driver may be a driver that drives the movement of the car through an electronically controlled motor or the like, which is not specifically limited in the embodiment of the present invention.
  • the side of the trolley is located on the side of the trolley, and the screw can also be located on both sides of the trolley.
  • An image collector is used to acquire a tumor image and send it to the processor.
  • the image collector can continuously acquire a tumor image during the breathing cycle, thereby forming a schematic diagram of the respiratory cycle motion curve corresponding to the tumor image as shown in FIG.
  • the amplitude of the corresponding moving tumor at the set point on the periodic respiratory motion curve, wherein the set point can be set by the time and the respiratory amplitude measured by the distance measuring device such as the CCD.
  • the processor is configured to determine a motion path of the tumor during the breathing cycle according to the respiratory cycle signal acquired by the respiratory monitor and the image acquisition device acquires the tumor image in the respiratory cycle, and send a driving signal to the driver, so that the driver drives the trolley to move.
  • the processor couples the respiratory cycle signal and the tumor image in the respiratory cycle to obtain a four-dimensional image of the tumor in the free breathing cycle of the patient.
  • the processor couples the respiratory cycle signal and the tumor image in the respiratory cycle to obtain a four-dimensional image of the tumor in the free breathing cycle of the patient.
  • obtaining the current image of the tumor comparing the current image of the tumor with the four-dimensional image of the tumor in the free breathing cycle of the patient, thereby determining the moving method and distance of the multi-leaf collimator, thereby driving the trolley to move to form a tracking of the tumor movement, achieving precision treatment.
  • a radiotherapy apparatus includes: two blade groups disposed opposite to each other and a small car, the blade group includes a plurality of blades, and the blade group is disposed on the trolley; the driving mechanism includes: a blade driving mechanism and a trolley driving mechanism Wherein the blade drive mechanism is used to drive the blade movement to form a conformable region through which the beam of rays can pass.
  • Trolley drive mechanism Used to drive the movement of the trolley; a respiratory monitor for acquiring the respiratory cycle signal; an image collector for acquiring the tumor image in the respiratory cycle; and a processor for obtaining the respiratory cycle signal acquired by the respiratory monitor and the image acquisition device
  • the tumor image within the respiratory cycle determines the direction and distance the tumor moves within the cross-section of the beam during the breathing cycle and sends a drive signal to the cart drive structure to drive the carriage to move, thereby causing the beam to pass through the beam formed by the blade Focusing on the tumor through the region allows real-time tracking of the tumor.
  • the moving carriage 12 drives the blade 111 to move, so that the blade 111 does not need to be moved again to form a shape corresponding to the tumor 3.
  • the adapted beam can pass through the shape of the region, avoiding changes in the shape of the beam traversable region formed by the multiple movement of the blade 111.
  • the radiation beam is periodically emitted; and the processor is further configured to determine, according to the motion path of the tumor in the respiratory cycle, the tumor to the next irradiation at the end of the previous irradiation The direction of motion of the tumor at the beginning and the distance of motion, thereby confirming the location of the tumor at the beginning of the next irradiation.
  • the cart drive mechanism is further configured to drive the cart to move during the time the beam is turned off, such that the beam formed by the beam passing through the blade at the beginning of the next shot can be focused on the tumor through the region.
  • the processor is further configured to determine the moving distance of the multi-leaf collimator according to the distance between the radiation source, the multi-leaf collimator, and the tumor, and the direction and distance the tumor moves within the cross section of the beam, and send Give the car drive mechanism.
  • a radiation therapy apparatus further comprising a treatment head 4 and a ring-shaped roller 22, as shown in FIG. 8, the treatment head 4 includes a radiation source 1 and a multi-leaf collimator 10, and the treatment head 4 is disposed on the annular roller 22, and rotatable around the circumference of the human body with the annular roller 22, the treatment head 4 is movable in the radial direction of the annular roller 22 (in the direction of 102 shown in Fig. 8) so as to be away from or close to the human body.
  • the annular drum 22 is further provided with a guide rail 21, and the treatment head 4 is movable along the guide rail 21.
  • the guide rail 21 is taken as a linear guide rail, and the guide rail may be an arc guide rail or the like to realize non-coplanar illumination.
  • the radiation source may be any one of an X-ray source, an electron source, a nuclear source (eg, Co-60), synchrotron radiation, or a neutron source.
  • the irradiation of the treatment head The radiation can be focused or conformal.
  • the multi-leaf collimator 10 includes two blade sets 11 and a trolley 12 disposed opposite to each other, wherein, in FIG.
  • the two blade sets are a first blade set 11a and a second blade set 11b, respectively;
  • the blade set 11 includes a first blade set 11a and a second blade set 11b, each of which includes a plurality of blades 111, respectively.
  • the cart 12 includes a first cart 12a and a second cart 12b, and the first vane group 11a and the second vane group 11b are located on the first cart 12a and the second cart 12b, respectively.
  • control method includes:
  • Step 101 driving the blade to move to form a beam traversable region that is adapted to the shape of the tumor.
  • the blade 111 is moved to form a beam traversable region 20 that is adapted to the shape of the tumor 3.
  • Step 102 Acquire a respiratory cycle signal and an image of the tumor during the respiratory cycle.
  • a respiratory monitoring system is formed by using a CCD camera or an infrared distance measuring device, thereby detecting a state change of the body surface in the respiratory motion, and obtaining a respiratory cycle and an image of the tumor in the respiratory cycle, as shown in the figure. 5 is shown.
  • Step 103 Determine a motion path of the tumor during the respiratory cycle based on the respiratory cycle signal and the image of the tumor during the respiratory cycle. Because tumors generally follow the movement of the respiratory cycle, for example, at the end of exhalation and inhalation, the amplitude of the tumor is small; at the beginning of exhalation and inhalation, the amplitude of the tumor is larger, as shown in Figure 5. As shown, the path of motion of the tumor during the breathing cycle can be determined.
  • Step 104 Obtain a current image of the tumor.
  • an image of a human tumor is formed by an image collector, such as a detector plate, that receives a beam of radiation that passes through a human tumor.
  • Step 105 Determine the direction and distance of movement of the tumor within the cross section of the beam of radiation beams based on the current image of the tumor.
  • the current image of the tumor may be a tumor image comprising one or more frames, combined with the motion path of the tumor, to estimate the direction and distance of movement of the tumor within the cross-section of the beam of radiation beams.
  • Step 106 Driving the trolley to move within a cross section of the beam of the radiation beam according to a direction and a distance in which the tumor moves within a section of the beam of the radiation beam, thereby causing the beam of the beam to pass through
  • the beam formed by the blade can be focused on the tumor through the area.
  • the multi-leaf collimator moves to the left by a distance d, and is generally d ⁇ d3.
  • step 106 specifically includes:
  • Step 1061 Determine the distance between the radiation source, the multi-leaf collimator, and the tumor.
  • the distance between the source 1 and the multi-leaf collimator 10 is d1
  • the distance between the multi-leaf collimator and the tumor 3 is d2.
  • Step 1062 Determine a moving distance of the multi-leaf collimator according to the distance between the radiation source, the multi-leaf collimator, and the tumor, and the direction and distance the tumor moves within the cross-section of the beam.
  • the tumor 3 moves a distance d3 in the cross section of the beam.
  • an approximate triangle is formed between the radiation source 1, the multi-leaf collimator 10 and the tumor 3, and the moving distance d of the multi-leaf collimator is approximately equal to (d1). ⁇ d3)/d2, that is, the moving distance of the multi-leaf collimator can be determined by calculation.
  • Step 1063 driving the trolley to move the moving distance along the moving direction of the tumor.
  • the driving carriage moves the moving distance along the moving direction of the tumor, so that the shape of the beam traversable region which is adapted to the shape of the tumor is not required to be moved again, and the shape of the beam traversable region formed by multiple movements of the blade is prevented from changing. .
  • the radiation beam is periodically emitted.
  • the radiation beam is periodically emitted, and the tumor moves with the breathing during the time that the beam is closed.
  • the step 106 includes: driving the trolley to move during the time when the beam is turned off, so that the beam formed by the beam passing through the blade can be focused on the tumor through the region at the beginning of the next irradiation. on. That is, the carriage moves with the movement of the tumor during the time when the beam is closed, so that at the beginning of the next cycle, the beam formed by the beam passing through the blade can be focused on the tumor through the region.
  • the multi-leaf collimator is fixed on the treatment head.
  • the treatment head is circumferentially rotatable, and the motion control method further comprises: driving the treatment head along the circumference of the axial direction. / or radial movement.
  • the treatment head can also be In the radial direction of the circumference, that is, the direction of 102, or the treatment head may be moved in the axial direction of the circumference, that is, in the direction of the guide rail 21, or the treatment head may be moved in both the axial direction and the radial direction, thereby realizing the blade at different illumination positions. Beams that fit different tumor shapes can pass through the area.
  • the circumferential direction of the treatment head can be moved along the guide rail 21 shown on the way 8.
  • the guide rail 21 can also be an arc-shaped guide rail, which can be the inner side of the circumference or the center of the circumference of the circumference.
  • the embodiment of the invention is not specifically limited.

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Abstract

A motion control method and a therapeutic device of a multileaf collimator (10) relating to the technical field of medical equipment. The multileaf collimator (10) can adjust a conformal position with patient's breath, thus avoiding the irradiation of normal tissues. A motion control method of a multileaf collimator (10), comprising: driving blades (111) to move to form a radiation beam-passable region (20) adapted to the shape of a tumor (3); acquiring respiratory cycle signals and images of the tumor (3) during respiratory cycles; determining a motion path of the tumor (3) during the respiratory cycles according to the respiratory cycle signals and the images of the tumor (3) during the respiratory cycle; acquiring a current image of the tumor (3); determining the direction and the distance of the movement of the tumor (3) within the radiation beam cross-section according to the current image of the tumor (3); and driving a small cart (12) to move within the radiation beam cross-section according to the direction and distance of the movement of the tumor (3) within the radiation beam cross-section, so that the radiation beam-passable region (20) formed when the radiation beam passes through the blades (111) is always focused on the tumor (3).

Description

一种多叶准直器的运动控制方法及治疗设备Motion control method and treatment device for multi-leaf collimator 技术领域Technical field
本发明涉及医疗器械技术领域,尤其涉及一种多叶准直器的运动控制方法及治疗设备。The invention relates to the technical field of medical instruments, in particular to a motion control method and a treatment device for a multi-leaf collimator.
背景技术Background technique
当前,放射治疗已经成为肿瘤治疗的三大手段之一,越来越多的肿瘤患者接受精确放射治疗。At present, radiation therapy has become one of the three major methods of cancer treatment, and more and more cancer patients receive precise radiation therapy.
如图1所示,为现有的一种治疗设备示意图,包括射线源1以及安装在射线源1射束出口处的多叶准直器10。如图2所示,多叶准直器10包括沿第一方向101相对设置的第一叶片组11a和第二叶片组11b、叶片驱动装置、第一小车12a、第二小车12b以及小车驱动装置。第一叶片组11a和第二叶片组11b分别包括多个叶片111,第一叶片组11a和第二叶片组11b分别位于第一小车12a和第二小车12b上。叶片驱动装置用于驱动第一叶片组11a和第二叶片组11b中的各叶片111沿第一方向101运动。As shown in FIG. 1, a schematic view of a conventional treatment device includes a radiation source 1 and a multi-leaf collimator 10 mounted at the beam exit of the radiation source 1. As shown in FIG. 2, the multi-leaf collimator 10 includes a first blade set 11a and a second blade set 11b disposed opposite each other in the first direction 101, a blade drive device, a first carriage 12a, a second carriage 12b, and a trolley drive device. . The first blade group 11a and the second blade group 11b respectively include a plurality of blades 111, and the first blade group 11a and the second blade group 11b are located on the first carriage 12a and the second carriage 12b, respectively. The blade driving device is for driving each of the first blade group 11a and the second blade group 11b to move in the first direction 101.
在治疗过程中,通过独立移动多个平行布置的叶片111,使其端部形成射束可穿过区域20,一般来说该射束可穿过区域20与肿瘤的形状相适应,实现适形的放射治疗。During the treatment, by independently moving a plurality of blades 111 arranged in parallel, the end forming beam can pass through the region 20, which in general can be adapted to the shape of the tumor through the region 20 to achieve conformality. Radiation therapy.
但在放射治疗过程中,患者的呼吸运动会造成肿瘤位移,不仅降低了治疗效率,还会使病人的正常组织接受到射线照射。现有的一种解决办法是扩大放疗靶区以充分覆盖运动的肿瘤,但采用这种方法会使病人更多的正常组织接受到射线照射,容易引发二次肿瘤,不利于患者的健康。现有还利用呼吸门控放疗技术,在病人屏气或吸气的末端对肿瘤区域进行放射治疗,但这种方法仅从一定程度上减少了肿瘤运动的影响,但对病人的呼吸和状态要求较高一般很难做到,且增加了放疗时间。However, during radiotherapy, the patient's respiratory motion causes tumor displacement, which not only reduces the treatment efficiency, but also allows the patient's normal tissue to receive radiation. One existing solution is to expand the target area of the radiotherapy to fully cover the moving tumor, but this method will cause more normal tissues of the patient to receive radiation, which may easily cause secondary tumors, which is not conducive to the health of the patient. Currently, respiratory-gated radiotherapy is also used to irradiate the tumor area at the end of the patient's breath holding or inhalation. However, this method only reduces the influence of tumor movement to a certain extent, but the patient's breathing and state requirements are relatively high. High is generally difficult to achieve and increases the time of radiotherapy.
发明内容Summary of the invention
本发明的实施例提供一种多叶准直器的运动控制方法及治疗设备,多叶准直器能够随着患者的呼吸调整适形的位置,从而避免对正 常组织的射线照射。Embodiments of the present invention provide a motion control method and a treatment apparatus for a multi-leaf collimator capable of adjusting a conformal position with a patient's breathing, thereby avoiding alignment Regular tissue radiation.
为达到上述目的,本发明的实施例采用如下技术方案:In order to achieve the above object, embodiments of the present invention adopt the following technical solutions:
第一方面,本发明实施例提供了一种多叶准直器的运动控制方法,所述多叶准直器包括:相对设置的两个叶片组以及小车,所述叶片组包括多个叶片,叶片组设置在所述小车上;所述控制方法包括:In a first aspect, an embodiment of the present invention provides a motion control method for a multi-leaf collimator, the multi-leaf collimator includes: two blade sets disposed opposite to each other, and a small car, the blade set including a plurality of blades, a blade set is disposed on the trolley; the control method includes:
驱动所述叶片移动,形成与肿瘤形状适应的射束可穿过区域;Driving the blade to move to form a beam traversable region adapted to the shape of the tumor;
获取呼吸周期信号以及在所述呼吸周期内肿瘤的图像;Obtaining a respiratory cycle signal and an image of the tumor during the respiratory cycle;
根据所述呼吸周期信号以及在所述呼吸周期内肿瘤的图像确定肿瘤在呼吸周期内的运动路径;Determining a path of motion of the tumor during the respiratory cycle based on the respiratory cycle signal and an image of the tumor during the respiratory cycle;
获取肿瘤的当前图像;Obtain the current image of the tumor;
根据所述肿瘤的当前图像确定所述肿瘤在射线束截面内运动的方向和距离;Determining a direction and a distance of movement of the tumor within a cross section of the beam based on a current image of the tumor;
根据所述肿瘤在射线束截面内运动的方向和距离驱动所述小车在射线束的截面内移动,从而使得射线束穿过所述叶片形成的射束可穿过区域聚焦在所述肿瘤上。The carriage is moved within the cross-section of the beam of light according to the direction and distance the tumor moves within the cross-section of the beam such that the beam formed by the beam of radiation through the blade can be focused on the tumor through the region.
可选的,所述射线束周期性的发出;Optionally, the beam is periodically emitted;
所述根据所述肿瘤在射线束的截面内运动的方向和距离驱动所述小车在射线束的截面内移动具体包括:The driving the carriage to move within the cross section of the beam according to the direction and distance of movement of the tumor within the cross section of the beam of beam specifically includes:
在所述射线束关闭照射的时间内驱动所述小车移动,使得下一照射开始时射线束穿过所述叶片形成的射束可穿过区域聚焦在所述肿瘤上。The carriage is moved during the time the beam is turned off, such that the beam formed by the beam through the blade at the beginning of the next illumination can be focused on the tumor through the region.
可选的,所述根据所述肿瘤在射线束的截面内移动的方向和距离驱动所述小车在射线束的截面内移动具体包括:Optionally, the driving the moving of the trolley in the cross section of the beam according to the direction and distance that the tumor moves within the cross section of the beam beam comprises:
确定射线源、多叶准直器以及肿瘤之间的距离;Determining the distance between the source of radiation, the multi-leaf collimator, and the tumor;
根据所述射线源、多叶准直器以及肿瘤之间的距离,以及所述肿瘤在射线束的截面内移动的方向和距离,确定多叶准直器的移动距离;Determining a moving distance of the multi-leaf collimator according to the distance between the radiation source, the multi-leaf collimator, and the tumor, and the direction and distance the tumor moves within the cross-section of the beam;
驱动所述小车沿所述肿瘤的运动方向移动所述移动距离。 The cart is driven to move the moving distance in a direction of movement of the tumor.
可选的,所述多叶准直器固定在治疗头上,所述治疗头可圆周旋转,所述运动控制方法还包括:Optionally, the multi-leaf collimator is fixed on the treatment head, and the treatment head is circumferentially rotatable, and the motion control method further includes:
驱动治疗头沿所述圆周的径向和/或轴向运动。The radial and/or axial movement of the treatment head along the circumference is driven.
另一方面,本发明实施例提供了一种放射治疗设备,包括:In another aspect, an embodiment of the present invention provides a radiotherapy apparatus, including:
射线源,用于发出射线束;a source of radiation for emitting a beam of radiation;
多叶准直器,包括:相对设置的两个叶片组、小车、叶片驱动机构以及小车驱动机构,所述叶片组包括多个叶片,叶片组设置在所述小车上;所述叶片驱动机构用于驱动所述叶片移动;所述小车驱动机构用于驱动所述小车移动;a multi-leaf collimator comprising: two blade sets disposed opposite each other, a carriage, a blade drive mechanism, and a trolley drive mechanism, the blade set including a plurality of blades, the blade set being disposed on the trolley; the blade drive mechanism Driving the blade to move; the trolley driving mechanism is configured to drive the trolley to move;
呼吸监测器,用于获取呼吸周期信号,并发送给处理器;a respiratory monitor for acquiring a respiratory cycle signal and transmitting it to the processor;
图像采集器,用于获取肿瘤图像,并发送给处理器;An image collector for acquiring a tumor image and transmitting it to the processor;
处理器,用于根据所述呼吸监测器获取的呼吸周期信号以及所述图像采集器获取在所述呼吸周期内的肿瘤图像确定肿瘤在呼吸周期内的运动路径,根据所述图像处理器获取的所述肿瘤的当前图像确定所述肿瘤在射线束截面内移动的方向和距离,并发送给所述小车驱动机构。a processor for determining a motion path of the tumor during a respiratory cycle according to a respiratory cycle signal acquired by the respiratory monitor and the image acquisition device acquiring a tumor image within the respiratory cycle, according to the image processor The current image of the tumor determines the direction and distance the tumor moves within the cross-section of the beam and is sent to the cart drive mechanism.
可选的,所述射线束周期性的发出;Optionally, the beam is periodically emitted;
所述小车驱动机构还用于,在所述射线束关闭照射的时间内驱动所述小车移动。The cart drive mechanism is further configured to drive the cart to move during a time when the beam is turned off.
可选的,所述多叶准直器包括一个小车,所述两个叶片组均设置在所述小车上;或者,Optionally, the multi-leaf collimator includes a small car, and the two blade sets are disposed on the trolley; or
所述多叶准直器包括两个小车,所述两个叶片组分别设置在所述两个小车上。The multi-leaf collimator includes two carts that are respectively disposed on the two carts.
可选的,所述小车驱动机构包括:丝杆以及驱动器,所述小车连接在所述丝杆上;所述驱动器用于驱动所述小车沿所述丝杆移动。Optionally, the trolley driving mechanism comprises: a screw rod and a driver, the trolley is connected to the screw rod; and the driver is configured to drive the trolley to move along the screw rod.
可选的,所述放射治疗设备包括治疗头以及环形滚筒,所述治疗头包括所述射线源和所述多叶准直器;Optionally, the radiotherapy apparatus comprises a treatment head and a ring-shaped drum, the treatment head comprising the radiation source and the multi-leaf collimator;
所述治疗头设置在所述环形滚筒上,并可随所述环形滚筒圆周旋转,治疗头在所述环形滚筒的径向可移动。 The treatment head is disposed on the annular drum and is rotatable with the circumference of the annular drum, and the treatment head is movable in a radial direction of the annular drum.
可选的,所述放射治疗设备包括治疗头以及导轨,所述治疗头包括所述射线源和所述多叶准直器;Optionally, the radiotherapy apparatus comprises a treatment head and a guide rail, the treatment head comprising the radiation source and the multi-leaf collimator;
所述治疗头沿所述导轨在所述环形滚筒的轴向可移动。The treatment head is movable along the guide rail in the axial direction of the annular drum.
本发明的实施例提供的一种多叶准直器的运动控制方法及治疗设备,放射治疗设备包括:相对设置的两个叶片组以及小车,叶片组包括多个叶片,叶片组设置在小车上;驱动机构,包括:叶片驱动机构以及小车驱动机构,其中,叶片驱动机构用于驱动叶片移动,以形成射线束可穿过的适形区域。小车驱动机构用于驱动小车移动;呼吸监测器,用于获取呼吸周期信号;图像采集器,用于获取呼吸周期内的肿瘤图像;处理器,用于根据呼吸监测器获取的呼吸周期信号以及图像采集器获取呼吸周期内的肿瘤图像确定肿瘤在呼吸周期内在射线束的截面内移动的方向和距离,并向小车驱动结构发出驱动信号,以驱动小车移动,从而使得射线束穿过叶片形成的射束可穿过区域聚焦在肿瘤上,实现肿瘤的实时追踪。Embodiments of the present invention provide a motion control method and a treatment apparatus for a multi-leaf collimator, the radiation therapy apparatus comprising: two blade sets disposed opposite to each other, and a trolley, the blade set including a plurality of blades, the blade group being disposed on the trolley The drive mechanism includes: a blade drive mechanism and a carriage drive mechanism, wherein the blade drive mechanism is configured to drive the blade to move to form a compliant region through which the beam of rays can pass. a trolley driving mechanism for driving the trolley to move; a respiratory monitor for acquiring a respiratory cycle signal; an image collector for acquiring a tumor image in the respiratory cycle; and a processor for the respiratory cycle signal and the image acquired according to the respiratory monitor The collector acquires the tumor image within the respiratory cycle to determine the direction and distance the tumor moves within the cross section of the beam during the breathing cycle, and sends a drive signal to the trolley drive structure to drive the trolley to move, thereby causing the beam to pass through the blade. The beam can be focused on the tumor through the area to achieve real-time tracking of the tumor.
附图说明DRAWINGS
为了更清楚地说明本发明实施例或现有技术中的技术方案,下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图仅仅是本发明的一些实施例,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其他的附图。In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the description of the prior art will be briefly described below. Obviously, the drawings in the following description are only It is a certain embodiment of the present invention, and other drawings can be obtained from those skilled in the art without any creative work.
图1为本发明实施例提供的一种治疗设备旋转照射治疗示意图;1 is a schematic view showing a treatment of a rotating treatment of a treatment device according to an embodiment of the present invention;
图2为多叶准直器拟合肿瘤形状形成射束可穿过区域的示意图;2 is a schematic view of a multi-leaf collimator fitting a tumor shape forming beam traversable region;
图3为本发明实施例提供的一种小车示意图;3 is a schematic diagram of a trolley according to an embodiment of the present invention;
图4为本发明实施例提供的一种多叶准直器的控制方法示意图;4 is a schematic diagram of a control method of a multi-leaf collimator according to an embodiment of the present invention;
图5为呼吸周期与呼吸周期内的肿瘤图像示意图;Figure 5 is a schematic diagram of a tumor image in a respiratory cycle and a respiratory cycle;
图6为本发明实施例提供的一种驱动小车在射线束的截面内移动的示意图;FIG. 6 is a schematic diagram of a driving car moving in a cross section of a beam according to an embodiment of the present invention; FIG.
图7为本发明实施例提供的射线源、多叶准直器和肿瘤的简化运动示意图; 7 is a schematic diagram showing a simplified movement of a radiation source, a multi-leaf collimator, and a tumor according to an embodiment of the present invention;
图8为治疗头沿导轨运动的示意图。Figure 8 is a schematic illustration of the movement of the treatment head along the guide rail.
附图标记:Reference mark:
1-射线源;3-肿瘤;4-治疗头;11-叶片组;12-多叶准直器;11a-第一叶片组;11b-第二叶片组;12a-第一小车;12b-第二小车;13-丝杆;20-射束可穿过区域;21-导轨;22-环形滚筒;111-叶片;121-上面板;122-下面板。1-ray source; 3-tumor; 4-treatment head; 11-blade group; 12-multi-leaf collimator; 11a-first blade group; 11b-second blade group; 12a-first car; 12b- Two trolleys; 13-spindle; 20-beam passable area; 21-rail; 22-annular drum; 111-blade; 121-upper panel; 122-lower panel.
具体实施方式detailed description
下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。The technical solutions in the embodiments of the present invention are clearly and completely described in the following with reference to the accompanying drawings in the embodiments of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, but not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative efforts are within the scope of the present invention.
本发明实施例提供了一种放射治疗设备,如图1所示,包括射线源1、多叶准直器10、呼吸监测器、图像采集器2以及处理器;其中,射线源1用于发出射线束。An embodiment of the present invention provides a radiation therapy apparatus, as shown in FIG. 1, including a radiation source 1, a multi-leaf collimator 10, a respiratory monitor, an image collector 2, and a processor; wherein the radiation source 1 is used to emit Beam of light.
多叶准直器10,如图1所示,包括:相对设置的两个叶片组11以及小车12,其中,图1中的两个叶片组分别为第一叶片组11a和第二叶片组11b;叶片组11,包括第一叶片组11a和第二叶片组11b,分别包括多个叶片111,第一叶片组11a和第二叶片组11b分别设置在小车12上。The multi-leaf collimator 10, as shown in FIG. 1, includes two opposite blade groups 11 and a trolley 12, wherein the two blade groups in FIG. 1 are a first blade group 11a and a second blade group 11b, respectively. The blade group 11, including the first blade group 11a and the second blade group 11b, respectively includes a plurality of blades 111, and the first blade group 11a and the second blade group 11b are respectively disposed on the carriage 12.
需要说明的是,本发明实施例中,第一叶片组11a和第二叶片组11b分别设置在小车12上,可以是小车包括第一小车12a和第二小车12b,第一叶片组11a和第二叶片组11b分别位于第一小车12a和第二小车12b上。或者,多叶准直器包括一个小车12,小车12可以是如图3所示,第一叶片组11a和第二叶片组11b均设置在小车12上,小车包括上面板121和下面板122,上面板121和下面板122均设置有开口,叶片形成的适形区域位于开口内,射线束穿过叶片形成的射束可穿过区域聚焦在肿瘤上。It should be noted that, in the embodiment of the present invention, the first blade group 11a and the second blade group 11b are respectively disposed on the trolley 12, and the trolley may include the first trolley 12a and the second trolley 12b, and the first blade group 11a and the first The two blade groups 11b are located on the first cart 12a and the second cart 12b, respectively. Alternatively, the multi-leaf collimator includes a cart 12, and the cart 12 may be as shown in FIG. 3. The first vane set 11a and the second vane set 11b are both disposed on the cart 12, and the cart includes an upper panel 121 and a lower panel 122. The upper panel 121 and the lower panel 122 are each provided with an opening in which the conformable region formed by the blade is located, and the beam formed by the beam passing through the blade can be focused on the tumor through the region.
多叶准直器还包括驱动机构,包括:叶片驱动机构以及小车驱动机构,其中,叶片驱动机构用于驱动叶片移动;小车驱动机构用于驱 动小车移动。具体的,叶片驱动机构可以是实现叶片沿第一方向101可移动的电子电气结构等,本发明实施例对其不做具体限定。The multi-leaf collimator further includes a driving mechanism including: a blade driving mechanism and a trolley driving mechanism, wherein the blade driving mechanism is used to drive the blade to move; the trolley driving mechanism is used to drive Move the car. Specifically, the blade driving mechanism may be an electronic and electrical structure that can move the blade in the first direction 101, and is not specifically limited in the embodiment of the present invention.
本发明实施例中,如图2所示,小车驱动机构包括:丝杆13以及驱动器(图中未示出),小车12连接在丝杆13上;驱动器用于驱动小车12沿丝杆13移动。本发明实施例中,驱动器可以接收处理器的驱动信号,并按照处理器的驱动信号驱动小车移动。具体的,驱动器可以是通过电子电气控制马达等驱动小车运动的驱动器,本发明实施例不做具体限定。图2中以丝杆位于小车的一侧为例,丝杆也可以是位于小车的两侧。In the embodiment of the present invention, as shown in FIG. 2, the trolley driving mechanism includes: a screw rod 13 and a driver (not shown), the trolley 12 is connected to the screw rod 13; and the driver is used to drive the trolley 12 to move along the screw rod 13. . In the embodiment of the invention, the driver can receive the driving signal of the processor and drive the trolley to move according to the driving signal of the processor. Specifically, the driver may be a driver that drives the movement of the car through an electronically controlled motor or the like, which is not specifically limited in the embodiment of the present invention. In Fig. 2, for example, the side of the trolley is located on the side of the trolley, and the screw can also be located on both sides of the trolley.
呼吸监测器,用于获取呼吸周期信号,并发送给处理器。呼吸监测器例如可以是通过在人体表面设置标记点,采用CCD摄像或者红外测距装置,组成呼吸检测器,检测呼吸运动中体表的状态变化,获得体表呼吸运动周期曲线。A breath monitor for acquiring a respiratory cycle signal and transmitting it to the processor. The respiratory monitor can be configured by setting a marker point on the surface of the human body, using a CCD camera or an infrared distance measuring device to form a respiratory detector, detecting a state change of the body surface in the respiratory motion, and obtaining a body surface respiratory cycle curve.
图像采集器,用于获取肿瘤图像,并发送给处理器。示例的,图像采集器可以在呼吸周期内不断获取肿瘤图像,从而形成如图4所示的呼吸周期运动曲线与肿瘤图像对应的示意图。周期性的呼吸运动曲线上设置点处对应的运动肿瘤的幅度变化,其中设置点可通过时间及CCD等距离测定装置测得的呼吸幅度进行设置。按如此对应关系可进行肿瘤组织的动态三维重建。An image collector is used to acquire a tumor image and send it to the processor. By way of example, the image collector can continuously acquire a tumor image during the breathing cycle, thereby forming a schematic diagram of the respiratory cycle motion curve corresponding to the tumor image as shown in FIG. The amplitude of the corresponding moving tumor at the set point on the periodic respiratory motion curve, wherein the set point can be set by the time and the respiratory amplitude measured by the distance measuring device such as the CCD. According to such a correspondence, dynamic three-dimensional reconstruction of tumor tissue can be performed.
处理器,用于根据呼吸监测器获取的呼吸周期信号以及图像采集器获取呼吸周期内的肿瘤图像确定肿瘤在呼吸周期内的运动路径,并向驱动器发出驱动信号,使得驱动器驱动小车移动。The processor is configured to determine a motion path of the tumor during the breathing cycle according to the respiratory cycle signal acquired by the respiratory monitor and the image acquisition device acquires the tumor image in the respiratory cycle, and send a driving signal to the driver, so that the driver drives the trolley to move.
具体的,处理器将呼吸周期信号及呼吸周期内的肿瘤图像进行耦合处理,取得患者自由呼吸周期内的肿瘤四维影像。从而获取肿瘤的当前图像,对比肿瘤的当前图像与患者自由呼吸周期内的肿瘤四维影像,从而确定多叶准直器的移动方法和距离,从而驱动小车移动以形成对肿瘤运动的跟踪,实现精准治疗。Specifically, the processor couples the respiratory cycle signal and the tumor image in the respiratory cycle to obtain a four-dimensional image of the tumor in the free breathing cycle of the patient. Thereby obtaining the current image of the tumor, comparing the current image of the tumor with the four-dimensional image of the tumor in the free breathing cycle of the patient, thereby determining the moving method and distance of the multi-leaf collimator, thereby driving the trolley to move to form a tracking of the tumor movement, achieving precision treatment.
本发明实施例提供的一种放射治疗设备,包括:相对设置的两个叶片组以及小车,叶片组包括多个叶片,叶片组设置在小车上;驱动机构,包括:叶片驱动机构以及小车驱动机构,其中,叶片驱动机构用于驱动叶片移动,以形成射线束可穿过的适形区域。小车驱动机构 用于驱动小车移动;呼吸监测器,用于获取呼吸周期信号;图像采集器,用于获取呼吸周期内的肿瘤图像;处理器,用于根据呼吸监测器获取的呼吸周期信号以及图像采集器获取呼吸周期内的肿瘤图像确定肿瘤在呼吸周期内在射线束的截面内移动的方向和距离,并向小车驱动结构发出驱动信号,以驱动小车移动,从而使得射线束穿过所述叶片形成的射束可穿过区域聚焦在所述肿瘤上,实现肿瘤的实时追踪。A radiotherapy apparatus according to an embodiment of the present invention includes: two blade groups disposed opposite to each other and a small car, the blade group includes a plurality of blades, and the blade group is disposed on the trolley; the driving mechanism includes: a blade driving mechanism and a trolley driving mechanism Wherein the blade drive mechanism is used to drive the blade movement to form a conformable region through which the beam of rays can pass. Trolley drive mechanism Used to drive the movement of the trolley; a respiratory monitor for acquiring the respiratory cycle signal; an image collector for acquiring the tumor image in the respiratory cycle; and a processor for obtaining the respiratory cycle signal acquired by the respiratory monitor and the image acquisition device The tumor image within the respiratory cycle determines the direction and distance the tumor moves within the cross-section of the beam during the breathing cycle and sends a drive signal to the cart drive structure to drive the carriage to move, thereby causing the beam to pass through the beam formed by the blade Focusing on the tumor through the region allows real-time tracking of the tumor.
需要说明的是,在肿瘤发生运动的情况下,本发明实施例提供的实施方式中,参照图2所示,通过移动小车12带动叶片111移动,从而无需再次移动叶片111形成与肿瘤3形状相适应的射束可穿过区域的形状,避免叶片111多次移动形成的射束可穿过区域的形状发生变化。It should be noted that, in the case of the tumor movement, in the embodiment provided by the embodiment of the present invention, as shown in FIG. 2, the moving carriage 12 drives the blade 111 to move, so that the blade 111 does not need to be moved again to form a shape corresponding to the tumor 3. The adapted beam can pass through the shape of the region, avoiding changes in the shape of the beam traversable region formed by the multiple movement of the blade 111.
在本发明实施例提供的另一种实施例方式中,射线束周期性的发出;则处理器还用于根据肿瘤在呼吸周期内的运动路径,确定肿瘤在上一照射结束时到下一照射开始时的肿瘤运动方向和运动距离,从而确认在下一照射开始时的肿瘤位置。小车驱动机构还用于,在射线束关闭照射的时间内驱动小车移动,从而使得在下一照射开始时射线束穿过所述叶片形成的射束可穿过区域聚焦在所述肿瘤上。In another embodiment provided by the embodiment of the present invention, the radiation beam is periodically emitted; and the processor is further configured to determine, according to the motion path of the tumor in the respiratory cycle, the tumor to the next irradiation at the end of the previous irradiation The direction of motion of the tumor at the beginning and the distance of motion, thereby confirming the location of the tumor at the beginning of the next irradiation. The cart drive mechanism is further configured to drive the cart to move during the time the beam is turned off, such that the beam formed by the beam passing through the blade at the beginning of the next shot can be focused on the tumor through the region.
示例的,处理器还用于根据射线源、多叶准直器以及肿瘤之间的距离,以及肿瘤在射线束的截面内移动的方向和距离,确定多叶准直器的移动距离,并发送给所述小车驱动机构。For example, the processor is further configured to determine the moving distance of the multi-leaf collimator according to the distance between the radiation source, the multi-leaf collimator, and the tumor, and the direction and distance the tumor moves within the cross section of the beam, and send Give the car drive mechanism.
本发明实施例提供的一种放射治疗设备,参照图8所示,还包括治疗头4以及环形滚筒22,治疗头4包括射线源1和多叶准直器10,治疗头4设置在环形滚筒22上,并可随环形滚筒22绕人体圆周旋转,治疗头4在环形滚筒22的径向(图8所示的102方向)可移动,从而远离或靠近人体。A radiation therapy apparatus according to an embodiment of the present invention, further comprising a treatment head 4 and a ring-shaped roller 22, as shown in FIG. 8, the treatment head 4 includes a radiation source 1 and a multi-leaf collimator 10, and the treatment head 4 is disposed on the annular roller 22, and rotatable around the circumference of the human body with the annular roller 22, the treatment head 4 is movable in the radial direction of the annular roller 22 (in the direction of 102 shown in Fig. 8) so as to be away from or close to the human body.
此外,本发明实施例中,参照图8所示,还包括环形滚筒22上还设置有导轨21,治疗头4沿导轨21可移动。图8中以导轨21为直线导轨为例,导轨也可以是弧形导轨等,从而实现非共面照射。In addition, in the embodiment of the present invention, as shown in FIG. 8, the annular drum 22 is further provided with a guide rail 21, and the treatment head 4 is movable along the guide rail 21. In FIG. 8, the guide rail 21 is taken as a linear guide rail, and the guide rail may be an arc guide rail or the like to realize non-coplanar illumination.
本发明实施例中,放射源可以是X射线源、电子源、核素源(例如Co-60)、同步辐射或中子源中的任意一种。其中,治疗头的照射 放射可以是聚焦或适形等。In an embodiment of the invention, the radiation source may be any one of an X-ray source, an electron source, a nuclear source (eg, Co-60), synchrotron radiation, or a neutron source. Among them, the irradiation of the treatment head The radiation can be focused or conformal.
本发明实施例提供了一种多叶准直器的运动控制方法,参照图2所示,多叶准直器10包括:相对设置的两个叶片组11以及小车12,其中,图1中的两个叶片组分别为第一叶片组11a和第二叶片组11b;叶片组11,包括第一叶片组11a和第二叶片组11b,每个叶片组分别包括多个叶片111。小车12包括第一小车12a和第二小车12b,第一叶片组11a和第二叶片组11b分别位于第一小车12a和第二小车12b上。An embodiment of the present invention provides a motion control method for a multi-leaf collimator. Referring to FIG. 2, the multi-leaf collimator 10 includes two blade sets 11 and a trolley 12 disposed opposite to each other, wherein, in FIG. The two blade sets are a first blade set 11a and a second blade set 11b, respectively; the blade set 11 includes a first blade set 11a and a second blade set 11b, each of which includes a plurality of blades 111, respectively. The cart 12 includes a first cart 12a and a second cart 12b, and the first vane group 11a and the second vane group 11b are located on the first cart 12a and the second cart 12b, respectively.
如图4所示,控制方法包括:As shown in FIG. 4, the control method includes:
步骤101、驱动叶片移动,形成与肿瘤形状适应的射束可穿过区域。参照图2所示,叶片111移动,从而形成与肿瘤3形状适应的射束可穿过区域20。 Step 101, driving the blade to move to form a beam traversable region that is adapted to the shape of the tumor. Referring to Figure 2, the blade 111 is moved to form a beam traversable region 20 that is adapted to the shape of the tumor 3.
步骤102、获取呼吸周期信号以及在呼吸周期内肿瘤的图像。Step 102: Acquire a respiratory cycle signal and an image of the tumor during the respiratory cycle.
示例的,通过在人体表面设置标记点,采用CCD摄像或者红外测距装置组成呼吸监测装系统,从而检测呼吸运动中体表的状态变化,获得呼吸周期与在呼吸周期内肿瘤的图像,如图5所示。For example, by setting a marker point on the surface of the human body, a respiratory monitoring system is formed by using a CCD camera or an infrared distance measuring device, thereby detecting a state change of the body surface in the respiratory motion, and obtaining a respiratory cycle and an image of the tumor in the respiratory cycle, as shown in the figure. 5 is shown.
步骤103、根据呼吸周期信号以及在呼吸周期内肿瘤的图像确定肿瘤在呼吸周期内的运动路径。由于肿瘤一般随呼吸周期的运动是规律性的,例如在呼气和吸气的末端,肿瘤的运动幅度较小;在呼气和吸气的开始时刻,肿瘤的运动幅度较大,如图5所示,从而可以确定肿瘤在呼吸周期内的运动路径。Step 103: Determine a motion path of the tumor during the respiratory cycle based on the respiratory cycle signal and the image of the tumor during the respiratory cycle. Because tumors generally follow the movement of the respiratory cycle, for example, at the end of exhalation and inhalation, the amplitude of the tumor is small; at the beginning of exhalation and inhalation, the amplitude of the tumor is larger, as shown in Figure 5. As shown, the path of motion of the tumor during the breathing cycle can be determined.
步骤104、获取肿瘤的当前图像。示例的,通过图像采集器,例如为探测器平板接收穿过人体肿瘤的射线束,从而形成人体肿瘤的图像。Step 104: Obtain a current image of the tumor. Illustratively, an image of a human tumor is formed by an image collector, such as a detector plate, that receives a beam of radiation that passes through a human tumor.
步骤105、根据肿瘤的当前图像确定肿瘤在放射束射线束的截面内运动的方向和距离。肿瘤的当前图像可以是包括一帧或多帧的肿瘤图像,结合肿瘤的运动路径,推算肿瘤在放射束射线束的截面内运动的方向和距离。Step 105: Determine the direction and distance of movement of the tumor within the cross section of the beam of radiation beams based on the current image of the tumor. The current image of the tumor may be a tumor image comprising one or more frames, combined with the motion path of the tumor, to estimate the direction and distance of movement of the tumor within the cross-section of the beam of radiation beams.
步骤106、根据肿瘤在放射束射线束的截面内运动的方向和距离驱动小车在放射束射线束的截面内移动,从而使得放射束射线束穿过 叶片形成的射束可穿过区域聚焦在肿瘤上。Step 106: Driving the trolley to move within a cross section of the beam of the radiation beam according to a direction and a distance in which the tumor moves within a section of the beam of the radiation beam, thereby causing the beam of the beam to pass through The beam formed by the blade can be focused on the tumor through the area.
示例的,参照图1、图2所示,若肿瘤3向左移动距离d3,则多叶准直器向左移动距离d,且一般的d≠d3。For example, referring to FIG. 1 and FIG. 2, if the tumor 3 moves to the left by a distance d3, the multi-leaf collimator moves to the left by a distance d, and is generally d≠d3.
本发明实施例提供的另一种实施方式中,如图6所示,上述步骤106具体包括:In another implementation manner provided by the embodiment of the present invention, as shown in FIG. 6, the foregoing step 106 specifically includes:
步骤1061、确定射线源、多叶准直器以及肿瘤之间的距离。Step 1061. Determine the distance between the radiation source, the multi-leaf collimator, and the tumor.
参照图1所示,射线源1与多叶准直器10之间的距离为d1,多叶准直器与肿瘤3之间的距离为d2。Referring to Figure 1, the distance between the source 1 and the multi-leaf collimator 10 is d1, and the distance between the multi-leaf collimator and the tumor 3 is d2.
步骤1062、根据射线源、多叶准直器以及肿瘤之间的距离,以及肿瘤在射线束截面内移动的方向和距离,确定多叶准直器的移动距离。参照图1、图2所示,肿瘤3在射线束截面内移动距离为d3。示例的,参照图1、图2以及图7所示,射线源1、多叶准直器10以及肿瘤3之间形成一种近似三角形,则多叶准直器的移动距离d近似等于(d1×d3)/d2,即通过计算可以确定多叶准直器的移动距离。Step 1062: Determine a moving distance of the multi-leaf collimator according to the distance between the radiation source, the multi-leaf collimator, and the tumor, and the direction and distance the tumor moves within the cross-section of the beam. Referring to Figures 1 and 2, the tumor 3 moves a distance d3 in the cross section of the beam. For example, referring to FIG. 1 , FIG. 2 and FIG. 7 , an approximate triangle is formed between the radiation source 1, the multi-leaf collimator 10 and the tumor 3, and the moving distance d of the multi-leaf collimator is approximately equal to (d1). ×d3)/d2, that is, the moving distance of the multi-leaf collimator can be determined by calculation.
步骤1063、驱动小车沿肿瘤的运动方向移动该移动距离。Step 1063, driving the trolley to move the moving distance along the moving direction of the tumor.
驱动小车沿肿瘤的运动方向移动该移动距离,从而无需再次移动叶片形成与肿瘤形状相适应的射束可穿过区域的形状,避免叶片多次移动形成的射束可穿过区域的形状发生变化。The driving carriage moves the moving distance along the moving direction of the tumor, so that the shape of the beam traversable region which is adapted to the shape of the tumor is not required to be moved again, and the shape of the beam traversable region formed by multiple movements of the blade is prevented from changing. .
本发明实施例提供的另一种实施方式中,射线束周期性的发出。示例的,参照图1所示,射线束周期性的发出,则在射线束关闭的时间内,肿瘤随着呼吸运动。本发明实施例提供的实施方式中,上述步骤106具体包括:在射线束关闭照射的时间内驱动小车移动,使得下一照射开始时射线束穿过叶片形成的射束可穿过区域聚焦在肿瘤上。即在射线束关闭照射的时间内小车随肿瘤的运动而发出移动,从而在下一周期开始时,使得射线束穿过叶片形成的射束可穿过区域聚焦在肿瘤上。In another embodiment provided by the embodiments of the present invention, the radiation beam is periodically emitted. By way of example, referring to Figure 1, the radiation beam is periodically emitted, and the tumor moves with the breathing during the time that the beam is closed. In the embodiment provided by the embodiment of the present invention, the step 106 includes: driving the trolley to move during the time when the beam is turned off, so that the beam formed by the beam passing through the blade can be focused on the tumor through the region at the beginning of the next irradiation. on. That is, the carriage moves with the movement of the tumor during the time when the beam is closed, so that at the beginning of the next cycle, the beam formed by the beam passing through the blade can be focused on the tumor through the region.
本发明实施例提供的另一实施方式中,多叶准直器固定在治疗头上,如图1所示,治疗头可圆周旋转,运动控制方法还包括:驱动治疗头沿圆周的轴向和/或径向运动。结合图8所示,治疗头还可以是 沿圆周的径向即102方向,或,治疗头可以是沿圆周的轴向即沿导轨21的方向移动,或者,治疗头在沿轴向和径向均可移动,从而实现在不同照射位置叶片拟合不同肿瘤形状的射束可穿过区域。In another embodiment provided by the embodiment of the present invention, the multi-leaf collimator is fixed on the treatment head. As shown in FIG. 1 , the treatment head is circumferentially rotatable, and the motion control method further comprises: driving the treatment head along the circumference of the axial direction. / or radial movement. As shown in Figure 8, the treatment head can also be In the radial direction of the circumference, that is, the direction of 102, or the treatment head may be moved in the axial direction of the circumference, that is, in the direction of the guide rail 21, or the treatment head may be moved in both the axial direction and the radial direction, thereby realizing the blade at different illumination positions. Beams that fit different tumor shapes can pass through the area.
示例的,治疗头沿圆周的轴向可以沿途8所示的导轨21移动,具体的,导轨21还可以弧形导轨,该弧形导轨可以是圆心在圆周的内侧,或者圆心在圆周的外侧,本发明实施例不做具体限定。For example, the circumferential direction of the treatment head can be moved along the guide rail 21 shown on the way 8. Specifically, the guide rail 21 can also be an arc-shaped guide rail, which can be the inner side of the circumference or the center of the circumference of the circumference. The embodiment of the invention is not specifically limited.
以上所述,仅为本发明的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到变化或替换,都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应以所述权利要求的保护范围为准。 The above is only a specific embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily think of changes or substitutions within the technical scope of the present invention. It should be covered by the scope of the present invention. Therefore, the scope of the invention should be determined by the scope of the appended claims.

Claims (10)

  1. 一种多叶准直器的运动控制方法,所述多叶准直器包括:相对设置的两个叶片组以及小车,所述叶片组包括多个叶片,叶片组设置在所述小车上;其特征在于,所述控制方法包括:A motion control method for a multi-leaf collimator, the multi-leaf collimator comprising: two blade sets disposed opposite to each other and a trolley, the blade set including a plurality of blades, the blade group being disposed on the trolley; The method is characterized in that the control method comprises:
    驱动所述叶片移动,形成与肿瘤形状适应的射束可穿过区域;Driving the blade to move to form a beam traversable region adapted to the shape of the tumor;
    获取呼吸周期信号以及在所述呼吸周期内肿瘤的图像;Obtaining a respiratory cycle signal and an image of the tumor during the respiratory cycle;
    根据所述呼吸周期信号以及在所述呼吸周期内肿瘤的图像确定肿瘤在呼吸周期内的运动路径;Determining a path of motion of the tumor during the respiratory cycle based on the respiratory cycle signal and an image of the tumor during the respiratory cycle;
    获取肿瘤的当前图像;Obtain the current image of the tumor;
    根据所述肿瘤的当前图像确定所述肿瘤在射线束的截面内运动的方向和距离;Determining a direction and a distance of movement of the tumor within a cross section of the beam of rays based on a current image of the tumor;
    根据所述肿瘤在射线束的截面内运动的方向和距离驱动所述小车在射线束截面内移动,从而使射线束穿过所述叶片形成的射束可穿过区域聚焦在所述肿瘤上。The carriage is moved within the cross-section of the beam according to the direction and distance of movement of the tumor within the cross-section of the beam such that the beam formed by the beam through the blade can be focused on the tumor through the region.
  2. 根据权利要求1所述的运动控制方法,其特征在于,所述射线束周期性的发出;The motion control method according to claim 1, wherein the radiation beam is periodically emitted;
    所述根据所述肿瘤在射线束的截面内运动的方向和距离驱动所述小车在射线束的截面内移动具体包括:The driving the carriage to move within the cross section of the beam according to the direction and distance of movement of the tumor within the cross section of the beam of beam specifically includes:
    在所述射线束关闭照射的时间内驱动所述小车移动,使得下一照射开始时射线束穿过所述叶片形成的射束可穿过区域聚焦在所述肿瘤上。The carriage is moved during the time the beam is turned off, such that the beam formed by the beam through the blade at the beginning of the next illumination can be focused on the tumor through the region.
  3. 根据权利要求1或2所述的运动控制方法,其特征在于,所述根据所述肿瘤在射线束的截面内移动的方向和距离驱动所述小车在射线束的截面内移动具体包括:The motion control method according to claim 1 or 2, wherein the driving the carriage in the section of the beam according to the direction and distance in which the tumor moves within the cross section of the beam beam comprises:
    确定射线源、多叶准直器以及肿瘤之间的距离;Determining the distance between the source of radiation, the multi-leaf collimator, and the tumor;
    根据所述射线源、多叶准直器以及肿瘤之间的距离,以及所述肿瘤在射线束的截面内移动的方向和距离,确定多叶准直器的移动距离;Determining a moving distance of the multi-leaf collimator according to the distance between the radiation source, the multi-leaf collimator, and the tumor, and the direction and distance the tumor moves within the cross-section of the beam;
    驱动所述小车沿所述肿瘤的运动方向移动所述移动距离。The cart is driven to move the moving distance in a direction of movement of the tumor.
  4. 根据权利要求1所述的运动控制方法,其特征在于,所述多叶准直器固定在治疗头上,所述治疗头可圆周旋转,所述运动控制方法还包括:The motion control method according to claim 1, wherein the multi-leaf collimator is fixed to the treatment head, and the treatment head is circumferentially rotatable, and the motion control method further comprises:
    驱动治疗头沿所述圆周的径向和/或轴向运动。The radial and/or axial movement of the treatment head along the circumference is driven.
  5. 一种放射治疗设备,其特征在于,包括: A radiotherapy apparatus, comprising:
    射线源,用于发出射线束;a source of radiation for emitting a beam of radiation;
    多叶准直器,包括:相对设置的两个叶片组、小车、叶片驱动机构以及小车驱动机构,所述叶片组包括多个叶片,叶片组设置在所述小车上;所述叶片驱动机构用于驱动所述叶片移动;所述小车驱动机构用于驱动所述小车移动;a multi-leaf collimator comprising: two blade sets disposed opposite each other, a carriage, a blade drive mechanism, and a trolley drive mechanism, the blade set including a plurality of blades, the blade set being disposed on the trolley; the blade drive mechanism Driving the blade to move; the trolley driving mechanism is configured to drive the trolley to move;
    呼吸监测器,用于获取呼吸周期信号,并发送给处理器;a respiratory monitor for acquiring a respiratory cycle signal and transmitting it to the processor;
    图像采集器,用于获取肿瘤图像,并发送给处理器;An image collector for acquiring a tumor image and transmitting it to the processor;
    处理器,用于根据所述呼吸监测器获取的呼吸周期信号以及所述图像采集器获取在所述呼吸周期内的肿瘤图像确定肿瘤在呼吸周期内的运动路径,根据所述图像处理器获取的所述肿瘤的当前图像确定所述肿瘤在射线束截面内移动的方向和距离,并发送给所述小车驱动机构。a processor for determining a motion path of the tumor during a respiratory cycle according to a respiratory cycle signal acquired by the respiratory monitor and the image acquisition device acquiring a tumor image within the respiratory cycle, according to the image processor The current image of the tumor determines the direction and distance the tumor moves within the cross-section of the beam and is sent to the cart drive mechanism.
  6. 根据权利要求5所述的放射治疗设备,其特征在于,所述射线束周期性的发出;The radiation therapy apparatus according to claim 5, wherein said radiation beam is periodically emitted;
    所述小车驱动机构还用于,在所述射线束关闭照射的时间内驱动所述小车移动。The cart drive mechanism is further configured to drive the cart to move during a time when the beam is turned off.
  7. 根据权利要求5所述的放射治疗设备,其特征在于,所述多叶准直器包括一个小车,所述两个叶片组均设置在所述小车上;或者,The radiation therapy apparatus according to claim 5, wherein said multi-leaf collimator comprises a trolley, and said two blade sets are each disposed on said carriage; or
    所述多叶准直器包括两个小车,所述两个叶片组分别设置在所述两个小车上。The multi-leaf collimator includes two carts that are respectively disposed on the two carts.
  8. 根据权利要求5所述的放射治疗设备,其特征在于,所述小车驱动机构包括:丝杆以及驱动器,所述小车连接在所述丝杆上;所述驱动器用于驱动所述小车沿所述丝杆移动。The radiation therapy apparatus according to claim 5, wherein said carriage driving mechanism comprises: a lead screw and a driver, said trolley being coupled to said screw; said driver for driving said carriage along said The screw moves.
  9. 根据权利要求5所述的放射治疗设备,其特征在于,所述放射治疗设备包括治疗头以及环形滚筒,所述治疗头包括所述射线源和所述多叶准直器;The radiation therapy apparatus according to claim 5, wherein said radiation therapy apparatus comprises a treatment head and an annular roller, said treatment head comprising said radiation source and said multi-leaf collimator;
    所述治疗头设置在所述环形滚筒上,并可随所述环形滚筒圆周旋转,治疗头在所述环形滚筒的径向可移动。The treatment head is disposed on the annular drum and is rotatable with the circumference of the annular drum, and the treatment head is movable in a radial direction of the annular drum.
  10. 根据权利要求5所述的放射治疗设备,其特征在于,所述放射治疗设备包括治疗头以及导轨,所述治疗头包括所述射线源和所述多叶准直器;The radiation therapy apparatus according to claim 5, wherein said radiation therapy apparatus comprises a treatment head and a guide rail, said treatment head comprising said radiation source and said multi-leaf collimator;
    所述治疗头沿所述导轨在所述环形滚筒的轴向可移动。 The treatment head is movable along the guide rail in the axial direction of the annular drum.
PCT/CN2016/091062 2016-07-22 2016-07-22 Motion control method and therapeutic device of multileaf collimator WO2018014343A1 (en)

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