WO2018004300A1 - Plasma generating device, and method for treating hair loss using same - Google Patents

Abstract

The present invention relates to a plasma generating device comprising: a plasma generating unit in which center electrodes are protrudingly formed to generate a plasma by means of a potential difference while being in a contact with a target object, and an outer electrode is formed along the circumferential direction outside the center electrodes; a power supply unit provided to supply power to the plasma generating unit; and a control unit connected to the power supply unit and provided to control the intensity of the plasma generated by the plasma generating unit. The plasma generating device is effective in generating and maintaining a uniform plasma and in improving safety of an object to be earthed. In cases where the plasma generating device of the present invention is used for treating hair loss, the device may be used in close contact with the curved surface of the scalp regardless of the shape of the head of an individual by comprising an elastic spring, and the center electrodes are implemented to be removable, thereby being able to be readily replaced as necessary. Thus, the plasma generating device is expected to be widely utilized in the fields of beauty and medical equipment.

Description

Plasma generator and hair loss treatment method using same

The present invention relates to a plasma generating apparatus and a hair loss treatment method using the same, and more particularly, to a plasma generating apparatus for generating a plasma by supplying a high current to the supplied gas and a hair loss treatment use thereof.

Solids with the lowest energy state of matter receive energy and are transferred to liquids or gases. In this case, when energy more than ionization energy is applied to the neutral gas, a plasma including electrons, ions, neutral atoms, and molecules may be generated by ionization and recombination of electrons and ions. The plasma is called an electrically ionized conductive gas species because the positive and negative charges are mixed in the plasma to maintain Brown's motion close to free particles, while maintaining electrical neutrality. Plasma classification criteria include plasma density, electron temperature, degree of thermal equilibrium (LTE or non-LTE) between species, generation mode, and application field. Plasma for research and manufacturing processes is usually either LTE or non-LTE, and the former is commonly referred to as thermal plasma and the latter as low temperature plasma. Atmospheric pressure plasma in low temperature plasma is mainly used in the field of surface modification and coating, environmental purification. Recently, a lot of atmospheric pressure plasma apparatuses have been studied due to the application of biomedical applications and biomedical applications (Korean Patent No. 1407672 and Korean Patent No. 1292268).

However, streamer discharges in biomedical applications pose a risk to biomedical applications. Streamer discharges are generally known to occur due to non-uniform discharges between electrodes applied to the dielectric at atmospheric pressure and parallel or gradient grounded electrodes (Brazilian Journal of Physics, 39 (2). ), pp. 322-325 and J. Phys. D: Appl. Phys, 46, 345204). The streamer discharge causes damage to biological tissue by concentrating relatively high energy at a local site, and therefore, an apparatus for generating a uniform non-thermal plasma is urgently needed to safely apply the plasma apparatus to the biomedical field. Accordingly, in recent years, a plasma generator incorporating a dielectric layer on the surface of the metal electrode has been introduced for stable plasma generation. In the conventional plasma generator, a flat dielectric layer is introduced to form a potential difference parallel to a large area, and a plasma is generated in a space between the electrode and the object with a gap between the object and the object. However, when the plasma is generated in such a large planar space, the plasma having the characteristics of the fluid is not uniformly maintained, but is caused to be oriented to one side. Therefore, a problem arises in maintaining a uniform plasma. Therefore, in order to apply the plasma generating apparatus in the field of cosmetics and medical devices it will be said that a uniform plasma generating technology.

On the other hand, the hair is maintained by repeating the hair growth and hair loss in cycles of growth (Anagen), degeneration (Catagen), and telogen (Telogen). Specifically, anagen, which grows hair, catagen, which is the time when growth ends and hairball shrinks, talogen, which is the time when the nipple stops working and stays in the scalp, and nipple It can be divided into generators, which are periods of starting activities, or developing new hairs, causing them to lose old hair. Therefore, hair loss is normal or normal, but a lot of hair in a growing state is usually hair loss (Alopecia) people have a lot of hair in the resting phase is visible hair loss phenomenon. Hair loss is caused by genetic factors as the main cause. Recently, hair loss population is gradually increasing due to the increase of social stress, westernized eating habits such as environmental pollution and instant food, frequent perm and dyeing, and poor scalp management. Although hair loss is not a life-threatening disease, it causes a lot of mental stress. Therefore, it is urgent to develop a technology for inhibiting hair loss or promoting new hair growth at a site where hair loss is in progress.

Recently, researches for applying plasma to biotechnology have been expanding, but studies on plasma application in scalp care and hair care have been insufficient. Korean Patent Laid-Open Publication No. 2011-0018708 (Plasma Scalp Care Device) and Korean Patent No. 1642183 (Plasma Hair Comb) describe a plasma device manufactured in the form of a helmet and a comb, respectively, but the device is a fixed type. As it is not possible to consider the shape of the individual head, it is not possible to generate a uniform plasma in the contact area, there is a problem in that the plasma generating unit and the scalp is not in close contact with the plasma cannot be uniformly delivered to the scalp.

Accordingly, the present invention relates to a plasma generating apparatus and a hair loss treatment method using the same, and when the plasma generating apparatus according to the present invention is used for hair loss treatment, the uniform plasma controlled within a predetermined intensity range is related to the individual head shape difference. Since it is possible to be in close contact with the curved surface of the scalp, it is expected to be greatly utilized in the field of beauty and medical devices.

The present invention has been made to improve the problems of the conventional conventional plasma generator as described above, providing a plasma generating device for generating a uniform plasma within a predetermined intensity range, and using the device for hair loss treatment Has its purpose.

However, the technical problem to be achieved by the present invention is not limited to the above-mentioned problem, another task that is not mentioned will be clearly understood by those skilled in the art from the following description.

Hereinafter, various embodiments described herein are described with reference to the drawings. In the following description, for a thorough understanding of the present invention, various specific details are set forth, such as specific forms, compositions, processes and the like. However, certain embodiments may be practiced without one or more of these specific details, or in conjunction with other known methods and forms. In other instances, well known processes and manufacturing techniques have not been described in particular detail in order to not unnecessarily obscure the present invention. Reference throughout this specification to "one embodiment" or "embodiment" means that a particular feature, form, composition or characteristic described in connection with the embodiment is included in one or more embodiments of the invention. Thus, the context of “in one embodiment” or “embodiment” expressed at various places throughout this specification does not necessarily represent the same embodiment of the invention. In addition, particular features, forms, compositions, or properties may be combined in any suitable manner in one or more embodiments.

Unless otherwise defined, all scientific and technical terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

In one embodiment of the present invention, "plasma" refers to a gas state in which electrons and negatively charged ions are separated at high temperatures. At this time, the charge separation degree is very high, but the negative and positive charges are the same as the whole. Generally, the state of matter is divided into three types: solid, liquid, and gas. Plasma is often called <fourth material state>. This is because when energy is applied to a solid, it becomes a liquid or a gas, and when high energy is applied to this gas state, the gas is separated into an electron and an atomic nucleus and becomes a plasma state.

If you want to use plasma in your daily life, you have to make it artificial, but in the whole universe, plasma is the most common state. It is estimated that 99% of the universe is plasma. Lightning, aurora borealis and ionic layers in the atmosphere are in a plasma state. When you go out of the atmosphere, plasma exists in the anti-Allen belt, where ions are trapped in the Earth's magnetic field, and in the solar wind pouring from the sun. The interior of the star or its surrounding gas is also in a plasma state. The hydrogen gas filling the space between the stars is also in a plasma state. Artificial plasma states that can be seen in everyday life include fluorescent lamps, mercury lamps, neon signs, plasma display panels (PDP), and the like.

In one embodiment of the present invention, "hair loss" refers to a state in which there is no hair at a site where hair normally should be present. Genetic factors act as the main cause, but the recent increase in social stress, hair loss population is gradually increasing due to westernized eating habits such as environmental pollution and instant food, frequent perm and dyeing, and poor scalp management.

Hair is maintained by repeating hair growth and hair loss in cycles of anagen, catagen, and telogen. Specifically, anagen, which grows hair, catagen, which is the time when growth ends and hairball shrinks, talogen, which is the time when the nipple stops working and stays in the scalp, and nipple It can be divided into generators, which are periods of starting activities, or developing new hairs, causing them to lose old hair. The hair grows naturally for men 3 to 5 years, for women 4 to 6 years, then for 30 to 45 days of degeneration, and for 3 to 4 months after the rest period. At the end of the off-season, the generator starts producing new hair. Hair loss is a normal phenomenon, but a normal person has a lot of hair in the growth phase, while alopecia usually has a lot of hair in the resting phase, which causes visible hair loss. The hallmark of people with alopecia is the miniaturization of hair. As hair loss progresses, the growth period is shortened, which causes hair to become smaller and smaller. Therefore, for the treatment of hair loss, it is important to allow the hair follicles in the resting phase to be rapidly converted into growth phases and to increase the shortened growth phases.

Alopecia can be distinguished according to gender and form. Male alopecia is characterized by male hormones called testosterone, a hormone that acts on muscle development and male organ development during puberty. When the 5 alpha-reductase enzyme converts it into a more potent hormone, Dihydrotestosterone (DHT), it acts on the hair follicles, causing the hair follicles to grow from the growth stage to the degenerative stage. Induces hair loss Therefore, the method of inhibiting the production of DHT by 5 alpha-reductase is mainly used to treat alopecia caused by this cause. Gynecologic alopecia is mainly caused by the quantitative reduction of estrogen hormones after menopause. Female alopecia, unlike the appearance of male alopecia, does not fall out of the front of the head, only the hair in the middle part is mainly lost. Alopecia in women has a lower association with 5 alpha-reductase than men. Thus, drugs that inhibit 5 alpha-reductase have little effect on postmenopausal alopecia women. Therefore, the treatment for such alopecia mainly uses minoxidil or estrogen. Alopecia areata is caused by autoimmune diseases, mental stress, or genetic predisposition. Hair loss of round or oval shape occurs, and it is characterized by ringworm whitening or hair growth wall. This alopecia areata is fundamentally different from androgenetic alopecia, and the treatment is also different, using a method of treating corticosteroids, or applying minoxidil to the affected area or artificially causing irritation in the affected area.

In the plasma generating apparatus according to the present invention, the center electrode for generating the plasma is protruded due to the potential difference, and the outer electrode is formed in the circumferential direction on the outer side of the center electrode to supply power to the plasma generator. And a control unit connected to the power supply unit and configured to control the intensity of the plasma generated by the plasma generation unit.

The plasma generating unit may further include a gas supply unit supplying a gas between the center electrode and the outer electrode.

In this case, the center electrode may include a metal electrode generating a potential difference using an applied current, and a dielectric layer formed to be bonded to the metal electrode to stabilize the plasma.

In addition, the dielectric layer may include a first dielectric layer formed to contact the object, and a second dielectric layer formed to be stacked between the first dielectric layer and the metal electrode.

In this case, the second dielectric layer may be formed by welding a metal material to the first dielectric layer by metal spraying to bond the metal electrode and the first dielectric layer.

On the other hand, the center electrode may be elastically supported to be compressed and restored along the curved surface of the object when in contact with the object.

In this case, the center electrode may be formed to protrude at intervals of 120 degrees along the circumferential direction.

In addition, the center electrode may be coupled to be detachable.

On the other hand, the control unit may transform the power input during energization so that the plasma is generated, it is also possible to recognize the intensity of the plasma applied to the object to maintain a predetermined intensity.

In the present invention, the plasma generating device can be used for cosmetic or medical treatment applications, for example, when used for hair loss suppression, or hair growth promoting use, it can be named as hair growth promoter.

In one embodiment of the present invention, "hair growth promoter" means a device for the purpose of promoting hair growth, inhibiting hair loss, or strengthening hair at a hair loss site for the purpose of treating hair loss.

In one embodiment of the present invention, "skin beauty device" is to promote the penetration of cosmetic ingredients (nutrition ingredients such as moisture, collagen) to be administered to the skin by porousizing the skin cell wall by treating energy such as plasma on the skin surface. Although it can improve a cosmetic effect, it is not limited to this.

In one embodiment of the invention "modification" is to change the physical or chemical properties of the subject, to change the structure of the subject, to change the electrical conductivity, to change the hydrophilic / lipophilic properties, or to include in the subject Concepts such as varying the content of a specific ingredient. For example, skin modification means changing physical or chemical properties of the skin. In the present invention, skin modification mainly means skin modification for cosmetic purposes, but is not limited thereto.

In one embodiment of the present invention, "transdermal absorption" refers to a drug delivery method of osmotic absorption of a drug through the skin instead of oral or injection administration. Since the drug is applied to the skin to absorb a certain concentration per predetermined time, there is an advantage that can maintain a constant drug concentration in the blood. For example, a tape attached with nitroglycerin, which is an angina treatment agent, is used in clinical practice.

However, in order to effectively increase the absorption rate in drug delivery using transdermal absorption, it is an important problem to solve the skin barrier.

Skin surrounds the whole body and consists of three layers of epidermis, dermis and subcutaneous fat. In the outermost epidermis, the stratum corneum is present, which acts as a skin barrier to protect the human body from various external sources of stimulation. The stratum corneum consists of multiple layers of flat keratinocytes, filled with keratin by a hydrophobic insoluble fibrous protein called keratin, and intercellular lipids composed of ceramides, free fatty acids, and cholesterol between the keratinocytes. It is filling the 'lamella structure'. This structural feature suppresses water evaporation of the skin and effectively protects the body from external stress or harmful stimuli, but also makes it difficult to absorb the active ingredients of pharmaceutical compositions or cosmetics (Drug Discovery Today. Technologies., 2). : 67-74, 2005). Lipids in the stratum corneum, unlike other common biofilms, are composed of ceramides, cholesterol, and free fatty acids that are not phospholipids. Ordinary biofilms containing phospholipids, sphingomyelin, and cholesterol are poorly permeable to water or low molecular weight substances that are soluble in water, and thus do not act as barriers. However, lipids such as ceramides, cholesterol, and free fatty acids in the stratum corneum are linearly well connected and perform an excellent barrier function that inhibits the penetration of water and hydrophilic substances. Absorption of substances through the stratum corneum occurs through intercellular pathways and direct transcellular pathways.

Therefore, in the drug delivery method through transdermal absorption, how to promote the absorption and maximize the effect of the active ingredient without irritating the skin remains a technical problem.

The plasma generating apparatus of the present invention has the effect of promoting the transdermal absorption of the substance, and when the plasma generating apparatus of the present invention is used for the purpose of promoting transdermal absorption as described above, it may be referred to as a "plasma transdermal absorption promoter". .

In one embodiment of the present invention, "pharmaceutical composition" means a composition to be administered for a specific purpose. For the purposes of the present invention, the pharmaceutical composition of the present invention means a medical and pharmaceutical preparation that can be used in combination with the plasma generating device of the present invention. For example, the pharmaceutical composition is a composition that increases the hair growth promoting effect or hair loss inhibiting effect, means a composition that is plasma-treated on the skin with the plasma hair growth promoter of the present invention, and applied to the plasma treatment area before and after the And sugars, proteins and pharmaceutically acceptable carriers, excipients or diluents. By "pharmaceutically acceptable" carrier or excipient is meant that it has been approved by the government's regulatory department, or listed in government or other generally approved pharmacopoeia for use in vertebrates, and more particularly in humans. . Pharmaceutical compositions in the present invention may be in the form of suspensions, solutions or emulsions in oily or aqueous carriers suitable for parenteral administration, and may include formulation agents such as suspending agents, stabilizers, solubilizers and / or dispersants. have. This form may be sterile and may be liquid. It can be stable under the conditions of manufacture and storage and can be preserved against the contaminating action of microorganisms such as bacteria or fungi. Alternatively, the pharmaceutical compositions in the present invention may be in sterile powder form for reconstitution with a suitable carrier prior to use. The pharmaceutical composition may be in unit-dose form, in ampoules, or in other unit-dose containers, or in multi-dose containers. Alternatively, the pharmaceutical composition may be stored in a freeze-dried (freeze-dried) state requiring only the addition of a sterile liquid carrier, for example water for injection just before use. Immediately injectable solutions and suspensions may be prepared as sterile powders, granules or tablets. Suitable excipients also include preservatives, suspending agents, stabilizers, dyes, buffers, antibacterial agents, antifungal agents, and isotonic agents, for example, sugars or sodium chloride. As used herein, the term "stabilizer" refers to a compound optionally used in the pharmaceutical compositions of the present invention to avoid the need for sulfite salts and to increase shelf life. Non-limiting examples of stabilizers include antioxidants.

The pharmaceutical composition may comprise one or more pharmaceutically acceptable carriers. The carrier may be a solvent or a dispersion medium. Non-limiting examples of pharmaceutically acceptable carriers include water, saline, ethanol, polyols (eg glycerol, propylene glycol and liquid polyethylene glycols), oils, and suitable mixtures thereof.

Parenteral formulations may be sterile. Non-limiting examples of sterilization techniques include filtration through bacterial-suppressive filters, terminal sterilization, incorporation of sterile preparations, irradiation, heating, vacuum drying and freeze drying.

In one embodiment of the present invention, "cosmetic composition" means a composition to be administered for a specific purpose. For the purpose of the present invention, the cosmetic composition of the present invention is a composition in which the effect is increased in combination with the plasma generating apparatus of the present invention, for example, plasma treatment on the skin with the plasma hair growth promoter of the present invention, and before and after the plasma treatment. Means the composition applied to the area, lotion, nutrition lotion, nutrition essence, massage cream, beauty bath additives, body lotion, body milk, bath oil, baby oil, baby powder, shower gel, shower cream, sunscreen lotion, sun Screen cream, suntan cream, skin lotion, skin cream, sunscreen cosmetic, cleansing milk, depilatory {cosmetic}, face and body lotion, face and body cream, skin whitening cream, hand lotion, hair lotion, cosmetic cream, Jasmine Oil, Bath Soap, Water Soap, Beauty Soap, Shampoo, Hand Cleanser (Hand Cleaner), Medicated Soap {Non-Medical}, Cream Soap, Facial Wash, Hairrin, Cosmetic Soap, Tooth Whitening Gel, toothpaste and the like. To this end, the cosmetic composition in the present invention may further include a suitable carrier, excipient or diluent commonly used in the preparation of the cosmetic composition. Carriers, excipients or diluents which may be further added to the cosmetic composition in the present invention include purified water, oils, waxes, fatty acids, fatty acid alcohols, fatty acid esters, surfactants, humectants, thickeners, antioxidants, viscosity stabilizers, Chelating agents, buffers, lower alcohols, and the like. In addition, a whitening agent, a moisturizing agent, vitamins, sunscreens, perfumes, dyes, antibiotics, antibacterial agents, antifungal agents may be included as necessary. The oil may be hydrogenated vegetable oil, castor oil, cottonseed oil, olive oil, palm oil, jojoba oil, avocado oil, wax, wax, carnauba, candelilla, montan, ceresin, liquid paraffin, lanolin Can be used. Stearic acid, linoleic acid, linolenic acid, oleic acid may be used as the fatty acid, and cetyl alcohol, octyldodecanol, oleyl alcohol, pantenol, lanolin alcohol, stearyl alcohol, hexadecanol may be used as fatty acid alcohol. And isopropyl myristate, isopropyl palmitate, butyl stearate may be used as the fatty acid ester. As surfactants, cationic surfactants, anionic surfactants and nonionic surfactants known in the art can be used, and surfactants derived from natural products are preferred as much as possible. In addition, it may include a hygroscopic agent, a thickener, an antioxidant, and the like, which are widely known in the cosmetic field, and their types and amounts are known in the art.

In one embodiment of the present invention, the plasma generating unit is formed by protruding the center electrode for generating a plasma by the potential difference in contact with the object, the outer electrode is formed along the circumferential direction on the outer side of the center electrode; A power supply unit provided to supply power to the plasma generation unit; And a control unit connected to the power supply unit and configured to control the intensity of the plasma generated by the plasma generation unit, wherein the plasma generation unit supplies gas between the center electrode and the outer electrode. And a gas supply unit, wherein the center electrode comprises: a metal electrode for generating a potential difference using an applied voltage; And a dielectric layer bonded to the metal electrode to stabilize the plasma, wherein the dielectric layer comprises: a first dielectric layer formed to contact an object; And a second dielectric layer formed to be stacked between the first dielectric layer and the metal electrode, wherein the second dielectric layer is configured to bond the metal electrode and the first dielectric layer to each other. 1. A plasma generating apparatus comprising a metal material deposited on a dielectric layer by a metal spray method, wherein the center electrode is elastically supported to be compressed and restored along a curved surface of the object when contacted with the object. It provides a plasma generating apparatus, wherein the center electrode is provided in a form protruding at intervals of 120 degrees along the circumferential direction, the center electrode is characterized in that coupled to detachable A plasma generating apparatus is provided, and the control unit generates a plasma Provided is a plasma generating apparatus characterized by transforming the input power when the lock is energized, to recognize the intensity of the plasma applied to the object to maintain a predetermined intensity.

In another embodiment of the invention, (a) contacting the plasma generating device of any one of claims 1 to 9 to the skin surface of the individual; And (b) generating a plasma, wherein the skin care method is a skin care method, wherein the skin care method is skin modification, moisturizing, whitening, wrinkle removal, hair loss inhibition, or hair growth promotion. In addition, the promotion of hair growth provides a skin care method, characterized in that to increase the number of hair or hair follicles, the promotion of hair growth is a skin care, characterized in that to increase the number of hair growth (anagen) or degenerative (catagen) hair follicles It provides a method, the plasma generation in the step (b) provides a skin cosmetic method, characterized in that applying an alternating voltage of 1.5 to 5.0kV, the plasma generation in the step (b) is 1 to 200 seconds It provides a skin care method, characterized in that for maintaining.

In another embodiment of the present invention, the method comprises the steps of: (a) contacting the plasma surface of the subject with a plasma generating device of any one of claims 1 to 9; And (b) generating a plasma; wherein the wound is a wound, skin wound by scratch, peeling, rash, inflammation, ulcer, or scratch, and (b) The plasma generation in the step) provides a wound treatment method characterized in that the application of an alternating voltage of 1.5 to 5.0kV, the plasma generation in the step (b) is maintained for 1 to 200 seconds Provide a method of treatment.

Hereinafter, the present invention will be described in detail step by step.

As described above, according to the plasma generating apparatus according to the present invention, there is an effect capable of generating plasma uniformly and safely. The plasma generating apparatus of the present invention has a stable plasma (dielectric barrier plasma) provided with protrusions having equal intervals along the circumferential direction, introducing a center electrode to which a dielectric layer and a metal electrode are joined, and introducing an outer electrode to the outside thereof. And control the intensity of the plasma through the control unit to prevent high energy from being concentrated in the local area. When the plasma generating apparatus of the present invention is used for hair loss treatment, the apparatus is adapted to be in close contact with the curved surface of the scalp regardless of individual head shape differences by introducing an elastic spring, and to implement a detachable center electrode. Since it can be easily replaced accordingly, it is expected that a large utilization in the field of beauty and medical devices.

1 is a perspective view of a plasma generating apparatus according to an embodiment of the present invention.

FIG. 2 is a perspective view of the plasma generator in FIG. 1, according to an embodiment of the present disclosure. FIG.

3A is a perspective view of a center electrode according to an embodiment of the present invention.

3B is a perspective view of a center electrode according to an embodiment of the present invention.

3C is a perspective view of a center electrode, according to one embodiment of the invention.

3D is a perspective view of a center electrode, according to one embodiment of the invention.

4 is a cross-sectional view of the center electrode according to an embodiment of the present invention.

5 is a block diagram of a control unit according to an embodiment of the present invention.

6 is a conceptual diagram at the time of plasma generation, according to an embodiment of the present invention.

7 is a front view of a plasma generating unit at the time of plasma generation according to an embodiment of the present invention.

8 is a graph of a potential difference generated between a cathode and an anode according to an embodiment of the present invention.

9A is a cross-sectional view of a state in which a center electrode and an object are spaced apart from each other according to an embodiment of the present invention.

9B is a cross-sectional view illustrating a plasma generation pattern in a state in which the center electrode is not in contact with an object according to an embodiment of the present invention.

9C is a cross-sectional view illustrating a plasma generation pattern in a state in which a center electrode is in complete contact with an object according to an embodiment of the present invention.

10 is a diagram showing the skin of a wound-induced and plasma-treated mouse according to an embodiment of the present invention.

11 is a view showing the skin of the mouse three weeks after wound induction, according to an embodiment of the present invention.

12 is a diagram showing a stained picture of mouse skin tissue treated with plasma after wound induction or untreated, according to one embodiment of the invention.

13 is a graph showing the results of hair follicle analysis in plasma or untreated mouse skin tissue after wound induction according to one embodiment of the present invention.

The plasma generating apparatus according to the present invention includes the center electrode 110 protruding at equal intervals along the circumferential direction to maintain a stable plasma continuously, and to bond the dielectric layer 113 and the metal electrode 111 to each other. The potential difference is stably maintained, the outer electrode 130 is introduced to generate a controlled stable plasma (dielectric barrier plasma), and the intensity of the plasma is controlled through the controller 300 so that a relatively high energy is applied to the localized portion. Prevent concentration In addition, the elastic spring 115 may be introduced to correspond to the curved surface of the target object, and the center electrode 110 may be detachably attached to allow replacement of the spring according to the target object.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, and it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples according to the gist of the present invention. .

Example  One. plasma  Manufacture of generator

The center electrode for generating a plasma by the potential difference is formed protruding and the outer electrode is formed in the circumferential direction on the outer side of the center electrode, a power supply unit provided to supply power to the plasma generating unit, and the power source A hair growth promoter using a plasma, comprising a control unit connected to a supply unit and provided to control the intensity of the plasma generated by the plasma generation unit.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.

Referring to FIG. 1, a plasma generating apparatus according to an embodiment of the present invention includes a plasma generating unit 100, a power supply unit 200, and a control unit 300. In this case, the power supply unit 200 is connected to one side of the control unit 300, and the plasma generation unit 100 is detachably connected to the other side of the control unit 300, but is not limited thereto. In a non-limiting embodiment, in the plasma generating apparatus of the present invention, the plasma generating unit 100 may be located at the side of the power supply unit 200 and the control unit 300 or may be configured as a separate unit.

1 and 2, the plasma generation unit 100 includes a center electrode 110, a plate 120, an outer electrode 130, and a gas supply unit 150. In this case, the center electrode 110 protrudes from the plate 120, and the outer electrode 130 is formed along the circumferential direction on the outer side of the center electrode 110, and the center electrode 110. The gas supply part 150 is provided between the outer electrode 130 and the outer electrode 130. However, in the non-limiting embodiment, the plasma generating apparatus of the present invention may be provided with the outer electrode 130. In this case, the plasma generating unit 100 includes a center electrode 110, a plate 120, and a gas supply unit 150. It is also possible that the gas supply unit 150 is unequipped. In this case, the plasma generator 100 includes a center electrode 110, a plate 120, and an outer electrode 130. In addition, in some non-limiting embodiments, the plasma generating apparatus of the present invention may be equipped with the outer electrode 130 and the gas supply unit 150. In this case, the plasma generator 100 includes a center electrode 110 and a plate 120.

On the other hand, in the present embodiment, the center electrode 110 may be coupled to the outer electrode 130 to be detachable. Therefore, the controller 300 and the plasma generator 100 are separated from each other, and the outer electrode 130 and the center electrode 110 are coupled to each other. In this case, the coupling of the control unit 300 and the plasma generating unit 110 may be screwed into each other by forming a screw thread on the end of the control unit 300 and the outer electrode 130, the control unit 300 and It is also possible to form a coupling hole and a hook such that the outer electrode 130 is hooked to each other.

Referring to FIG. 3, the center electrode 110 is connected to the controller 300 and includes a metal electrode 111, a dielectric layer 113, and an elastic spring 115.

Meanwhile, in the present embodiment, the center electrode 110 is formed to protrude from the plate 120, and the three center electrodes 110 are disposed to have a predetermined interval along the circumferential direction. At this time, the center electrode 110 has a semi-spherical end shape in the form of a cylinder (see FIG. 3A), and is separated without a plate (see FIG. 3B) at the bottom, and has the plate 120b at the bottom and the plate ( 120b) and when the end is formed in the shape of a truncated cone (see FIG. 3C), and when the plate 120c is provided at the bottom and connected to the plate 120c and is formed in the form of a triangular pyramid (FIG. 3D). Can be implemented in various forms.

Meanwhile, referring to FIG. 4, the cross-sectional structure of the center electrode 110 includes a metal electrode 111, a dielectric layer 113, and an elastic spring 115.

The metal electrode 111 has a shape protruding to the outside, the dielectric layer 113 is laminated on a protruding surface of the metal electrode 111 with a uniform thickness. In addition, the elastic spring 115 is connected to a surface of the metal electrode 111 in the direction of the control unit 300.

4 and 9, the dielectric layer 113 is the first dielectric layer 113a formed at the outermost portion so as to be in contact with the target object 1 and the second dielectric layer stacked inside the first dielectric layer 113a ( 113b). Meanwhile, in the present embodiment, the double layer structure is applied, but the present invention is not limited thereto. A single layer structure formed of a single material and a multilayer structure formed of a plurality of layers are also possible.

In this embodiment, the first as a dielectric material, the first dielectric layer (113a), the ceramic using the material, and the second dielectric layer (113b) include, but the use of the metal material is not limited to, alumina (Al ₂ O _3), zirconia It is also possible to apply (ZrO ₂ ) or the like.

The elastic spring 115 is formed to elastically support the dielectric layer 113 and the metal electrode 111. At this time, the elastic spring 115 is shown in the form of a coil spring coupled to each of the protrusions 117, but is not limited to this, the spring coil shape as well as the plate spring to elastically support the entire dielectric layer 113. It is possible to form in the form.

The outer electrode 130 is disposed outside the center electrode 110, and the inner circumferential surface of the outer electrode 130 faces the center electrode 110. That is, the center electrode 110 is positioned in the center direction of the inner circumferential surface of the outer electrode 130.

The gas supply unit 150 includes a gas storage unit (not shown), is connected to the control unit 300, and is disposed between the center electrode 110 and the outer electrode 130. That is, the gas storage part (not shown) is formed to communicate the spaced space between the center electrode 110 and the outer electrode 130.

One end of the power supply unit 200 is connected to the control unit 300, and the other end of the power supply unit 200 is connected to an external power source, and the internal power source is accommodated therein. That is, the power supply unit 200 is formed to be detachable from the external power supply device, and is formed to accommodate a built-in power supply device such as a battery.

Referring to FIG. 5, the control unit 300 includes a switching unit 310, a sensor unit 330, an output control unit 350, and a transformer 370. In this case, the switching unit 310 is connected to the power supply unit 200 and the output control unit 350, the sensor unit 330 and the plasma generating unit 100 and the output control unit 350 The output control unit 350 is connected to the switching unit 310 and the sensor unit 330.

When the plasma generating apparatus of the present invention is used as a medical device, a closed circuit for sensing a feedback signal of the plasma generating unit may be configured, and when used as a beauty device, the sensor unit and the feedback signal coming into the sensor unit may be output. It is also possible to control by the control unit (upper switch step switch of the device).

1 and 5, when describing the operation and effect of the plasma generating apparatus according to an embodiment of the present invention, when an external power or internal power is applied to the power supply unit 200 through a switch operation, Power is applied to the switching unit 310, the voltage of the power applied to the switching unit 31 is transformed to a predetermined appropriate voltage. On the other hand, the power source required for plasma processing uses a low frequency of 30 or more and 99 kHz or less, the power consumption of the plasma processing is 1 or more and 15 W or less, and the ground current of the plasma processing is 0.1 or more and 9.9 mA or less.

The current transformed by the switching unit 310 is applied to the plasma generating unit 100. In this case, when power is applied to the metal electrode 111, the center electrode 110 generates a potential difference with the periphery of the center electrode 110 including the outer electrode 130, air, and the object 1. Let's do it.

8 shows a graph of the potential difference generated between the cathode and the anode. At this time, ions are collected in the vicinity of the positive electrode and the negative electrode, and an electric field is formed by the ions, thereby lowering the action (potential difference) as an electrode (sheath). That is, the potential difference becomes relatively low near the positive electrode and the negative electrode, and a target potential difference is generated in a region where no sheath occurs, and a plasma is generated in this region.

At the same time, power is also applied to the gas supply unit 150 so that the gas for supplying plasma is supplied from the gas supply unit 150. In this case, the gas supplied from the gas supply unit 150 may be a clean dry air (CDA), air, argon, neon, helium, or mixed gas. Can be used.

As a result, the plasma is generated by the gas supplied from the gas supply unit 150 and the potential difference generated by the center electrode 110.

In this case, the energy generated by the potential difference in the metal electrode 111 is stabilized while passing through the dielectric layer 113 to prevent high energy from being concentrated at the localized portion. Therefore, the plasma is generated while passing through the dielectric layer 113 to prevent damage to a target material including biological tissues. In addition, the dielectric layer 113 may include the first dielectric layer 113a and the second dielectric layer 113b to control the distribution of energy of plasma generated from the center electrode 110.

Meanwhile, in the present embodiment, the second dielectric layer 113b is welded to the first dielectric layer 113a by metalspraying (welding a metal or metal compound in a semi-melt state onto a nonmetal surface). In this case, a space is not formed between the first dielectric layer 113a formed of ceramic and the second dielectric layer 113b welded by a metal spray method, and the second dielectric layer 113b of the metal material and the metal are coated. The electrode 111 may be bonded through brazing (ceramic metal brazing). Therefore, according to the present embodiment, since the first dielectric layer 113a, the second dielectric layer 113b, and the metal electrode 111 of the ceramic material are bonded to each other, no space is generated and energy is concentrated at a localized portion. It can prevent and supply stable energy.

Meanwhile, referring to FIG. 3, in the present invention, the three center electrodes 110 are disposed at 120 degree intervals along the circumferential direction. In this case, the three center electrodes 110 are in contact with the object 1, and the surface of the center electrode 110 in direct contact with the object 1 is grounded so that plasma is not generated. However, plasma is generated on the surface of the center electrode 110 which is not in direct contact with the object 1 (see FIGS. 6, 7 and 9c).

9 illustrates a process of generating plasma from the center electrode 110 and contacting the object 1 according to the present invention. First, plasma is not generated when the center electrode 110 is remotely spaced apart from the object 1 (FIG. 9A). When the center electrode 110 approaches the object 1, a plasma is generated by the potential difference between the object 1 and the center electrode 110. In this case, in the protruding form of the center electrode 110, the electric field is concentrated in the direction forming the shortest distance with the object 1, and as a result, the plasma is also concentrated (FIG. 9B). As shown in FIG. 9C, when the center electrode 110 is completely in contact with the object 1, no plasma is generated at a portion of the center electrode 110 which is in contact with the object 1, but is separated from the object 1. In that part, there is still a potential difference and a plasma is generated.

Therefore, according to the present invention, a ring-shaped plasma is formed around the center electrode 110 which protrudes in the contact with the object 1. In this case, unlike the conventional flat electrode, it is possible to continuously maintain a plasma of a uniform and stable shape. That is, in the conventional flat electrode having a relatively large area, unlike the phenomenon in which the plasma having a fluid property is concentrated in one direction, it is stable around the center electrode 110 according to the present invention. There is an effect that the plasma is continuously maintained.

In addition, referring to FIG. 4, in the present invention, the center electrode 110 is elastically supported by the elastic spring 115 to be compressed and restored along the curved surface of the object when in contact with the object. Therefore, it can be used easily also for the object which has a curved surface, such as a human body.

Meanwhile, in the present invention, the center electrode 110 is formed to be detachable, so that the center electrode 110 can be replaced with a suitable center electrode according to an object, and can be easily replaced even when a failure occurs.

At this time, the outer electrode 130 is grounded with the object, causing a potential difference with the center electrode 110 and at the same time to prevent the potential rises.

The plasma generated by the plasma generator 100 is measured by the sensor unit 330. The sensor unit 330 measures the intensity of the plasma electrical signal generated by the plasma generating unit 100 and sends a signal to the output control unit 350. In addition, the sensor unit 330 measures whether there is a malfunction such as an arc (a phenomenon in which the electrode melts due to a strong current and a discharge occurs) or a disconnection that may be generated during a plasma generation process, and if the malfunction occurs, the output control unit ( Signal a malfunction of 350).

The output control unit 350 receives a signal for the plasma intensity sent from the sensor unit 330 and compares it with information about a previously input plasma intensity. In this case, when the plasma intensity transmitted from the sensor unit 330 is out of the range of the pre-input plasma intensity, the output control unit 350 may switch the switching unit so that the plasma intensity is within the range of the pre-input plasma intensity. The control signal is sent to 310 to control the amount of current. In addition, when the output controller 350 transmits a malfunction occurrence signal from the sensor unit 330, the output controller 350 shuts off power.

Therefore, the plasma generating apparatus according to the present invention includes the center electrode 110 protruding at equal intervals along the circumferential direction to maintain a stable plasma and to maintain the dielectric layer 113 and the metal electrode 111. Bonding to maintain the potential difference stably, introducing the outer electrode 130 to generate a controlled stable plasma (dielectric barrier plasma), and control the intensity of the plasma through the control unit 300 to relatively high local Prevents energy concentration In addition, the elastic spring 115 may be introduced to correspond to the curved surface of the target object, and the center electrode 110 may be detachably attached to allow replacement of the spring according to the target object.

Example 2. Confirmation of hair loss treatment effect of hair growth accelerator

Example 2-1. Preparation and Plasma Treatment of Hair Loss Animal Models

Six-week-old males of C57BL / 6J mice were randomly classified as shown in Table 1, and wounds were induced using a 8 mm biopsy punch on both sides of the dorsal of the mouse.

Production Example	Number of objects per group (n)	Remarks
Negative control	4	Non-Plasma Treated Mice After Wound Induction
Plasma treated group	4	Plasma Treated Mice After Wound Induction
Positive Control (Normal)	4	Wound-induced normal mice

The wound was washed with sterile saline and then treated with plasma using the hair growth promoter prepared in Example 1. An AC voltage of 2.5 to 3.0 kV was applied as a voltage for discharging the plasma, and the treatment was performed twice a week for 20 seconds on the first and third days of the experiment.

After the plasma treatment, a ring made of medical silicone (inner diameter 12 mm, 2 mm thick), which was a guide ring, was attached to the wound, and four places were fixed using a medical stapler to prevent the wound tissue from healing itself by contraction. This is shown in FIG. 8.

The wound with the guide ring is well ventilated, well passed through oxygen and water vapor, is waterproof, and wrapped with 3M's Tegaderm transparent band, which is resistant to bacterial infection. More wrapped. The wound was disinfected every 3 days and the tissue regeneration and hair growth of the wound were visually confirmed for 3 weeks (21 days). The photograph at the time of the said tissue observation is shown in FIG.

Example 2-2. Histological staining of wound tissue regeneration

Three weeks after wound induction, the wound tissues of the mice were biopsied and subjected to H & E staining. The staining results are shown in FIG. 10.

Experimental results showed that re-epithelialization of wound-induced tissues recovered to a similar extent (about 50%) between the negative control and plasma treatment groups. However, wound repair, which indicates complete wound healing, was improved by about 4.2% in the plasma treated group (16.7%) compared to the control group (12.5%).

Example 2-3. Counting and classification of wound hair

Hair follicles in the tissue photographs were counted to evaluate hair growth following plasma treatment of the wound site, and the hair follicle states of the tissues were classified into anagen, catagen, and telogen, respectively. The result is shown in FIG.

As a result, the total number of hair follicles was found to be greater in the plasma treated group (12.8) than in the negative control group (7.8) or the positive control group (9). The above result is also consistent with the H & E staining result of Example 2-2.

In the hair follicle classification results, the proportion of hair growth (4.5) and degenerative (5.8) hairs in the plasma treated group was lower than that of the negative control group (1.3 growth stage, 2.3 degenerative stage) or positive control group (3.3 growth stage, 4.5 degenerative stage). It was confirmed to be high. As a result, it was confirmed that the plasma treatment induced hair growth promotion.

Although the present invention has been described in detail through specific examples, it is intended to specifically describe the present invention, and the present invention is not limited thereto, and the present invention has ordinary knowledge in the art within the technical spirit of the present invention. It is obvious that the modification or improvement is possible by the ruler.

 All simple modifications and variations of the present invention fall within the scope of the present invention, and the specific scope of protection of the present invention will be apparent from the appended claims.

[Description of the code]

100: plasma generating unit

110: center electrode

111: metal electrode

113: dielectric layer

115: elastic spring

130: outer electrode

150: gas supply unit

200: power supply

300: control unit

310: switching unit

330: sensor

350: output control unit

Plasma generating device according to the present invention has an effect that can generate a plasma uniformly and safely, it is expected to be greatly utilized in the field of cosmetic and medical devices.

Claims (19)

1. A plasma generating part protruding from the center electrode for generating a plasma due to a potential difference in contact with an object, and an outer electrode formed along the circumferential direction of the outer electrode;

   A power supply unit provided to supply power to the plasma generation unit; And

   And a control unit connected to the power supply unit and configured to control the intensity of the plasma generated by the plasma generation unit.
2. The method of claim 1,

   The plasma generation unit,

   And a gas supply unit for supplying a gas between the center electrode and the outer electrode.
3. The method of claim 1,

   The center electrode,

   A metal electrode generating a potential difference using an applied voltage; And

   And a dielectric layer bonded to the metal electrode to stabilize the plasma.
4. The method of claim 3, wherein

   The dielectric layer,

   A first dielectric layer formed to contact the object; And

   And a second dielectric layer formed to be stacked between the first dielectric layer and the metal electrode.
5. The method of claim 4, wherein

   The second dielectric layer is,

   And a metal material is welded to the first dielectric layer by metal spraying so as to bond the metal electrode and the first dielectric layer.
6. The method of claim 1,

   The center electrode,

   Plasma generator, characterized in that when the contact with the object is elastically supported to enable compression and restoration along the curved surface of the object.
7. The method of claim 1,

   The center electrode,

   Plasma generator, characterized in that formed in a shape protruding at intervals of 120 degrees along the circumferential direction.
8. The method of claim 1,

   The center electrode,

   Plasma generator, characterized in that coupled to be detachable.
9. The method of claim 1,

   The control unit,

   And transforming the power input during energization so that the plasma is generated, and recognizing the intensity of the plasma applied to the object to maintain a predetermined intensity.
10. (a) contacting the plasma generating device of any one of claims 1 to 9 with the skin surface of the individual; And

    (b) generating a plasma.
11. The method of claim 10,

    The skin beauty is characterized in that the skin is modified, moisturizing, whitening, wrinkle removal, hair loss suppression, or hair growth promotion.
12. The method of claim 11,

    The hair growth promotion,

    Skin cosmetic method, characterized in that to increase the number of hair or hair follicles.
13. The method of claim 11,

    The hair growth promotion,

    A method for skin beauty, characterized in that to increase the number of anagen or catagen hair follicles.
14. The method of claim 10,

    Plasma generation in the step (b) is characterized in that to apply an alternating voltage of 1.5 to 5.0kV, skin cosmetic method.
15. The method of claim 10,

    Plasma generation in the step (b) is characterized in that it is maintained for 1 to 200 seconds, skin care method.
16. (a) contacting the plasma generating device of any one of claims 1 to 9 with the surface of the subject's skin; And

    (b) generating a plasma.
17. The method of claim 16,

    And the wound is skin damage by cuts, peels, rashes, inflammation, ulcers, or scratches.
18. The method of claim 17,

    Plasma generation in the step (b) is characterized in that to apply an alternating voltage of 1.5 to 5.0kV, wound treatment method.
19. The method of claim 17,

    The plasma generation in step (b) is characterized in that for 1 to 200 seconds, wound treatment method.

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