WO2017221068A1 - Light-adjustable hydrogel and bioanalogic intraocular lens - Google Patents

Light-adjustable hydrogel and bioanalogic intraocular lens Download PDF

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Publication number
WO2017221068A1
WO2017221068A1 PCT/IB2017/000911 IB2017000911W WO2017221068A1 WO 2017221068 A1 WO2017221068 A1 WO 2017221068A1 IB 2017000911 W IB2017000911 W IB 2017000911W WO 2017221068 A1 WO2017221068 A1 WO 2017221068A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogel
lens
ophthalmic
pendant
optical
Prior art date
Application number
PCT/IB2017/000911
Other languages
English (en)
French (fr)
Inventor
Vladimir Stoy
Vaclav Petrak
Miroslav Dudic
Original Assignee
Medicem Ophthalmic (Cy) Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/190,715 external-priority patent/US10441676B2/en
Application filed by Medicem Ophthalmic (Cy) Limited filed Critical Medicem Ophthalmic (Cy) Limited
Priority to CA3027646A priority Critical patent/CA3027646A1/en
Priority to MX2018016173A priority patent/MX2018016173A/es
Priority to JP2019520513A priority patent/JP2019520966A/ja
Priority to AU2017283194A priority patent/AU2017283194A1/en
Priority to EP17758264.0A priority patent/EP3474910A1/de
Priority to KR1020197002326A priority patent/KR20190039401A/ko
Priority to CN201780045664.1A priority patent/CN109789241A/zh
Priority to BR112018076401A priority patent/BR112018076401A2/pt
Publication of WO2017221068A1 publication Critical patent/WO2017221068A1/en
Priority to IL263706A priority patent/IL263706A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1627—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing index of refraction, e.g. by external means or by tilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1659—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having variable absorption coefficient for electromagnetic radiation, e.g. photochromic lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/13—Phenols; Phenolates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/16—Nitrogen-containing compounds
    • C08K5/17—Amines; Quaternary ammonium compounds
    • C08K5/18—Amines; Quaternary ammonium compounds with aromatically bound amino groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
    • C08L33/08—Homopolymers or copolymers of acrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
    • C08L33/10—Homopolymers or copolymers of methacrylic acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
PCT/IB2017/000911 2016-06-23 2017-06-21 Light-adjustable hydrogel and bioanalogic intraocular lens WO2017221068A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA3027646A CA3027646A1 (en) 2016-06-23 2017-06-21 Light-adjustable hydrogel and bioanalogic intraocular lens
MX2018016173A MX2018016173A (es) 2016-06-23 2017-06-21 Lente intraocular bioanalogico y de hidrogel ajustable por luz.
JP2019520513A JP2019520966A (ja) 2016-06-23 2017-06-21 光調節可能なハイドロゲルおよび生体類似型眼内レンズ
AU2017283194A AU2017283194A1 (en) 2016-06-23 2017-06-21 Light-adjustable hydrogel and bioanalogic intraocular lens
EP17758264.0A EP3474910A1 (de) 2016-06-23 2017-06-21 Lichteinstellbares hydrogel und bioanaloge intraokularlinse
KR1020197002326A KR20190039401A (ko) 2016-06-23 2017-06-21 광-조절 가능한 하이드로겔 및 바이오아날로직 안내 렌즈
CN201780045664.1A CN109789241A (zh) 2016-06-23 2017-06-21 可调光的水凝胶和生物模拟人工晶状体
BR112018076401A BR112018076401A2 (pt) 2016-06-23 2017-06-21 hidrogel covalentemente reticulado, implantes que o utilizam, lentes intraoculares de hidrogel leves, ajustáveis e bioanalógicas e métodos para efetuar tais ajustes
IL263706A IL263706A (en) 2016-06-23 2018-12-13 Light-adjustable hydrogel and bioanalogic intraocular lens

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15/190,715 US10441676B2 (en) 2013-01-15 2016-06-23 Light-adjustable hydrogel and bioanalogic intraocular lens
US15/190,715 2016-06-23

Publications (1)

Publication Number Publication Date
WO2017221068A1 true WO2017221068A1 (en) 2017-12-28

Family

ID=59714057

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2017/000911 WO2017221068A1 (en) 2016-06-23 2017-06-21 Light-adjustable hydrogel and bioanalogic intraocular lens

Country Status (10)

Country Link
EP (1) EP3474910A1 (de)
JP (1) JP2019520966A (de)
KR (1) KR20190039401A (de)
CN (1) CN109789241A (de)
AU (1) AU2017283194A1 (de)
BR (1) BR112018076401A2 (de)
CA (1) CA3027646A1 (de)
IL (1) IL263706A (de)
MX (1) MX2018016173A (de)
WO (1) WO2017221068A1 (de)

Cited By (6)

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WO2020025616A1 (de) 2018-08-01 2020-02-06 Rowiak Gmbh Vorrichtung und verfahren zur erzeugung einer aperturblende in einer intraokularlinse
WO2020216928A1 (en) 2019-04-26 2020-10-29 Merck Patent Gmbh System and method
US11678979B2 (en) 2019-12-12 2023-06-20 Carl Zeiss Meditec Ag Eye implant for an accommodative intraocular lens
US11702396B2 (en) 2017-02-15 2023-07-18 Johnson & Johnson Surgical Vision, Inc. Hydrophobic compounds for optically active devices
US11753387B2 (en) 2017-02-15 2023-09-12 Johnson & Johnson Surgical Vision, Inc. Compounds for optically active devices
US11958819B2 (en) 2015-08-21 2024-04-16 Johnson & Johnson Surgical Vision, Inc. Compounds for optically active devices

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116421141B (zh) * 2023-06-12 2023-09-05 江西师范大学 非植入囊式眼压测量角膜接触镜及其测量方法
CN117379170B (zh) * 2023-12-13 2024-04-12 北京北琪医疗科技股份有限公司 一种具有显现射频热场的专用体模及其制备方法和应用

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