WO2017217681A3 - Method for controlling neurotransmitter using cucurbituril and use thereof - Google Patents

Method for controlling neurotransmitter using cucurbituril and use thereof Download PDF

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Publication number
WO2017217681A3
WO2017217681A3 PCT/KR2017/005770 KR2017005770W WO2017217681A3 WO 2017217681 A3 WO2017217681 A3 WO 2017217681A3 KR 2017005770 W KR2017005770 W KR 2017005770W WO 2017217681 A3 WO2017217681 A3 WO 2017217681A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurotransmitter
controlling
cucurbituril
release
uril
Prior art date
Application number
PCT/KR2017/005770
Other languages
French (fr)
Korean (ko)
Other versions
WO2017217681A2 (en
Inventor
김기문
이남기
공보경
최봉규
Original Assignee
기초과학연구원
포항공과대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 기초과학연구원, 포항공과대학교 산학협력단 filed Critical 기초과학연구원
Publication of WO2017217681A2 publication Critical patent/WO2017217681A2/en
Publication of WO2017217681A3 publication Critical patent/WO2017217681A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a composite containing cucurbit[n]uril and a snare protein, to a cosmetic composition containing cucurbit[n]uril for ameliorating skin wrinkles or aging, to a pharmaceutical composition for controlling the release of a neurotransmitter, to a kit for controlling the release of a neurotransmitter, and to a method for controlling the release of a neurotransmitter.
PCT/KR2017/005770 2016-06-13 2017-06-02 Method for controlling neurotransmitter using cucurbituril and use thereof WO2017217681A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020160072978A KR101997474B1 (en) 2016-06-13 2016-06-13 method for controlling neurotransmitter using the cucurbit[n]uril, and use thereof
KR10-2016-0072978 2016-06-13

Publications (2)

Publication Number Publication Date
WO2017217681A2 WO2017217681A2 (en) 2017-12-21
WO2017217681A3 true WO2017217681A3 (en) 2018-02-01

Family

ID=60664106

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2017/005770 WO2017217681A2 (en) 2016-06-13 2017-06-02 Method for controlling neurotransmitter using cucurbituril and use thereof

Country Status (2)

Country Link
KR (1) KR101997474B1 (en)
WO (1) WO2017217681A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102017240B1 (en) 2018-08-23 2019-09-02 주식회사 하울바이오 Anti-VAMP2 antibodies inhibiting SNARE complex and use thereof
KR102297991B1 (en) 2019-10-11 2021-09-07 주식회사 하울바이오 Anti-Syntaxin 1A antibodies inhibiting SNARE complex and use thereof
KR102274841B1 (en) 2019-10-16 2021-07-12 주식회사 하울바이오 Anti-SNAP 25 antibodies inhibiting SNARE complex and use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005010004A1 (en) * 2003-07-26 2005-02-03 Postech Foundation Nano-particles comprising cucurbituril derivatives, pharmaceutical composition containing the same, and process for the preparation thereof
KR20070050747A (en) * 2005-11-12 2007-05-16 학교법인 포항공과대학교 The application using non-covalent bond between a cucurbituril derivative and a ligand
WO2011077099A2 (en) * 2009-12-23 2011-06-30 Cambridge Enterprise Limited Methods for the purification of cucurbituril
KR101273066B1 (en) * 2009-10-30 2013-06-10 (주)아모레퍼시픽 Composition for Reducing Skin Pore Size or Secreting Sebum Containing flower extract of Potentilla chinensis
KR101544254B1 (en) * 2012-12-12 2015-08-12 포항공과대학교 산학협력단 Cucurbiturill[7] as amyloid-beta nanofibril controller and dispersing agent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365734B1 (en) 1999-10-21 2002-04-02 Pohang University Of Science And Technology Foundation Cucurbituril derivatives, their preparation methods and uses
HUE025656T2 (en) 2004-03-03 2016-04-28 Revance Therapeutics Inc Topical application and transdermal delivery of botulinum toxins

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005010004A1 (en) * 2003-07-26 2005-02-03 Postech Foundation Nano-particles comprising cucurbituril derivatives, pharmaceutical composition containing the same, and process for the preparation thereof
KR20070050747A (en) * 2005-11-12 2007-05-16 학교법인 포항공과대학교 The application using non-covalent bond between a cucurbituril derivative and a ligand
KR101273066B1 (en) * 2009-10-30 2013-06-10 (주)아모레퍼시픽 Composition for Reducing Skin Pore Size or Secreting Sebum Containing flower extract of Potentilla chinensis
WO2011077099A2 (en) * 2009-12-23 2011-06-30 Cambridge Enterprise Limited Methods for the purification of cucurbituril
KR101544254B1 (en) * 2012-12-12 2015-08-12 포항공과대학교 산학협력단 Cucurbiturill[7] as amyloid-beta nanofibril controller and dispersing agent

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GONG, BOK YOUNG ET AL.: "High Affinity Host-guest FRET Pair for Single-vesicle Content-mixing Assay: Observation of Flickering Fusion Events", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 137, 10 July 2015 (2015-07-10), pages 8908 - 8911, XP055456919 *
SHETTY F, DINESH ET AL.: "Can We Beat the Biotin-avidin Pair?: Cucurbit[7]uril-based Ultrahigh Affinity Host-guest Complexes and Their Applications", CHEMICAL SOCIETY REVIEWS, vol. 44, 5 October 2015 (2015-10-05), pages 8747 - 8761, XP055456926 *

Also Published As

Publication number Publication date
KR101997474B1 (en) 2019-07-09
WO2017217681A2 (en) 2017-12-21
KR20170140549A (en) 2017-12-21

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