WO2017216719A1 - Buchu preparation - Google Patents

Buchu preparation Download PDF

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Publication number
WO2017216719A1
WO2017216719A1 PCT/IB2017/053499 IB2017053499W WO2017216719A1 WO 2017216719 A1 WO2017216719 A1 WO 2017216719A1 IB 2017053499 W IB2017053499 W IB 2017053499W WO 2017216719 A1 WO2017216719 A1 WO 2017216719A1
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
buchu
oil extract
formulation
preservative
Prior art date
Application number
PCT/IB2017/053499
Other languages
French (fr)
Inventor
Ernst Albert Gerhard HARTWIG
Original Assignee
Pgr Developments (Pty) Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pgr Developments (Pty) Ltd filed Critical Pgr Developments (Pty) Ltd
Publication of WO2017216719A1 publication Critical patent/WO2017216719A1/en
Priority to ZA2018/08521A priority Critical patent/ZA201808521B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers

Definitions

  • the present invention relates to a Buchu preparation.
  • the present invention relates to a Buchu preparation for use as a preservative.
  • Buchu is one of the best known medicinal plants of South Africa and is indigenous to the Cedarberg Mountains and surrounding areas. Despite its popularity little scientific evidence exists about the various medicinal uses of this small fynbos shrub from the family Rustaceae.
  • the two primary species of Buchu used commercially are Agasthoma betulina (round-leaf Buchu) and Agathosma crenulata (oval-leaf Buchu).
  • Buchu oil is also used in the flavourant and fragrance industry, currently the largest commercial use thereof.
  • Buchu extract (with its natural odour) is currently marketed as an active ingredient in formulations for the purpose of including the natural antiinflammatory, antibacterial and anti-fungal properties of Buchu in products.
  • Buchu oil is typically prepared in a (high vacuum) low steam distillation process in which the Buchu oil required for the commercial market is extracted from the plant material and separated from the by-products of this steam distillation process.
  • a Buchu preparation which includes a Buchu oil extract and being adapted to be used as a natural preservative.
  • the natural preservative may be used in the cosmetics industry and/or food industry.
  • a preservative for the cosmetics and/or food industry includes a Buchu oil extract.
  • a gel preparation includes a Buchu preparation as a natural preservative.
  • the Buchu preparation may be about 0.25% concentration of the gel preparation.
  • the Buchu preparation may be the sole preservative in the gel preparation.
  • the Buchu preparation may act as active ingredient and natural preservative.
  • the Buchu preparation may include a synthetic preparation.
  • the Buchu preparation may be a certified organic product.
  • the Buchu preparation may be odourless.
  • the Buchu oil extract may be odourless and hence increase the potential applications of the extract and Buchu preparation.
  • Buchu extract typically has a very intense odour which may exclude it as an ingredient since it easily overpowers the fragrance of a product.
  • the Buchu oil extract and/or Buchu preparation may have various concentrations.
  • the Buchu oil extract and/or Buchu preparation may be odourless.
  • the Buchu oil extract and/or Buchu preparation may be an organic or conventional extract.
  • the Buchu oil extract and/or Buchu preparation may be in combination with other natural extracts.
  • the Buchu oil extract and/or Buchu preparation may be effective against Aspergillus Niger.
  • a topical formulation including at least one Buchu oil extract as natural preservative and active ingredient.
  • a topical formulation including at least one active ingredient and natural preservative originating from at least one Buchu oil extract or bio-active fraction thereof in a pharmaceutically acceptable form.
  • the invention extends further to the use of at least one Buchu oil extract as an active ingredient and natural preservative in the manufacture of a medicament.
  • the topical formulation may be a therapeutic formulation.
  • the topical formulation may be a gel or cream.
  • a Buchu preparation which includes a Buchu oil extract and being adapted to be used as a natural preservative.
  • the natural preservative can be used in the cosmetics industry and/or food industry.
  • the Buchu preparation can be about 0.25% concentration of the gel preparation.
  • the Buchu preparation can be the sole preservative in the gel preparation.
  • the Buchu preparation acts as active ingredient and natural preservative.
  • the Buchu preparation can include a synthetic preparation.
  • the Buchu preparation can be a certified organic product.
  • the Buchu preparation can be odourless.
  • the Buchu oil extract can be odourless and hence increase the potential applications of the extract and Buchu preparation.
  • Bot extract typically has a very intense odour which may exclude it as an ingredient since it easily overpowers the fragrance of a product.
  • the Buchu oil extract and/or Buchu preparation can have various concentrations.
  • the Buchu oil extract and/or Buchu preparation can be odourless.
  • the Buchu oil extract and/or Buchu preparation can be an organic or conventional extract.
  • the Buchu oil extract and/or Buchu preparation can be in combination with other natural extracts.
  • the Buchu oil extract and/or Buchu preparation can be effective against Aspergillus Niger.
  • a topical formulation including at least one Buchu oil extract as natural preservative and active ingredient.
  • a topical formulation including at least one active ingredient and natural preservative originating from at least one Buchu oil extract or bio-active fraction thereof in a pharmaceutically acceptable form.
  • the invention extends further to the use of at least one Buchu oil extract as an active ingredient and natural preservative in the manufacture of a medicament.
  • the topical formulation can be a therapeutic formulation.
  • the topical formulation can be a gel or cream.
  • Buchu oil can be used as a natural preservative in the cosmetic and foods industry.
  • All natural and organic formulations can benefit from including the extract as a preservative as the extract is 100% natural and offer a certified organic format option.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a Buchu preparation, which includes a Buchu oil extract and being adapted to be used as a natural preservative. The natural preservative is adapted to be used in the cosmetics industry and/or food industry. The preparation is adapted to act as active ingredient and natural preservative. The preparation may be odourless and may be effective against Aspergillus Niger.

Description

BUCHU PREPARATION
FIELD OF INVENTION
The present invention relates to a Buchu preparation.
More particularly, the present invention relates to a Buchu preparation for use as a preservative.
BACKGROUND TO INVENTION
Buchu is one of the best known medicinal plants of South Africa and is indigenous to the Cedarberg Mountains and surrounding areas. Despite its popularity little scientific evidence exists about the various medicinal uses of this small fynbos shrub from the family Rustaceae. The two primary species of Buchu used commercially are Agasthoma betulina (round-leaf Buchu) and Agathosma crenulata (oval-leaf Buchu). Besides its medicinal properties, Buchu oil is also used in the flavourant and fragrance industry, currently the largest commercial use thereof. Buchu extract (with its natural odour) is currently marketed as an active ingredient in formulations for the purpose of including the natural antiinflammatory, antibacterial and anti-fungal properties of Buchu in products.
Buchu oil is typically prepared in a (high vacuum) low steam distillation process in which the Buchu oil required for the commercial market is extracted from the plant material and separated from the by-products of this steam distillation process.
It is an object of the invention to suggest a novel Buchu preparation. SUMMARY OF INVENTION
According to the invention, a Buchu preparation which includes a Buchu oil extract and being adapted to be used as a natural preservative.
The natural preservative may be used in the cosmetics industry and/or food industry.
Also according to the invention, a preservative for the cosmetics and/or food industry includes a Buchu oil extract.
Yet further according to the invention, a gel preparation includes a Buchu preparation as a natural preservative.
The Buchu preparation may be about 0.25% concentration of the gel preparation.
The Buchu preparation may be the sole preservative in the gel preparation.
The Buchu preparation may act as active ingredient and natural preservative.
The Buchu preparation may include a synthetic preparation.
The Buchu preparation may be a certified organic product.
The low concentration of the Buchu preparation in gel and other preparations makes it extremely cost effective for use in formulations/preparations.
The Buchu preparation may be odourless.
The Buchu oil extract may be odourless and hence increase the potential applications of the extract and Buchu preparation. (Buchu extract typically has a very intense odour which may exclude it as an ingredient since it easily overpowers the fragrance of a product.)
The Buchu oil extract and/or Buchu preparation may have various concentrations.
The Buchu oil extract and/or Buchu preparation may be odourless.
The Buchu oil extract and/or Buchu preparation may be an organic or conventional extract.
The Buchu oil extract and/or Buchu preparation may be in combination with other natural extracts.
The Buchu oil extract and/or Buchu preparation may be effective against Aspergillus Niger.
Yet further according to the invention, there is provided a topical formulation including at least one Buchu oil extract as natural preservative and active ingredient.
Yet further according to the invention, there is provided a topical formulation including at least one active ingredient and natural preservative originating from at least one Buchu oil extract or bio-active fraction thereof in a pharmaceutically acceptable form.
The invention extends further to the use of at least one Buchu oil extract as an active ingredient and natural preservative in the manufacture of a medicament. The topical formulation may be a therapeutic formulation. The topical formulation may be a gel or cream. BRIEF DESCRIPTION OF EXAMPLE
The invention will now be described by way of example.
In accordance with the invention, there is provided a Buchu preparation which includes a Buchu oil extract and being adapted to be used as a natural preservative.
The natural preservative can be used in the cosmetics industry and/or food industry.
The Buchu preparation can be about 0.25% concentration of the gel preparation.
The Buchu preparation can be the sole preservative in the gel preparation.
The Buchu preparation acts as active ingredient and natural preservative.
The Buchu preparation can include a synthetic preparation.
The Buchu preparation can be a certified organic product.
The low concentration of the Buchu preparation in gel and other preparations makes it extremely cost effective for use in formulations/preparations.
The Buchu preparation can be odourless. The Buchu oil extract can be odourless and hence increase the potential applications of the extract and Buchu preparation. (Buchu extract typically has a very intense odour which may exclude it as an ingredient since it easily overpowers the fragrance of a product.)
The Buchu oil extract and/or Buchu preparation can have various concentrations.
The Buchu oil extract and/or Buchu preparation can be odourless.
The Buchu oil extract and/or Buchu preparation can be an organic or conventional extract.
The Buchu oil extract and/or Buchu preparation can be in combination with other natural extracts.
The Buchu oil extract and/or Buchu preparation can be effective against Aspergillus Niger.
Yet further according to the invention, there is provided a topical formulation including at least one Buchu oil extract as natural preservative and active ingredient.
Yet further according to the invention, there is provided a topical formulation including at least one active ingredient and natural preservative originating from at least one Buchu oil extract or bio-active fraction thereof in a pharmaceutically acceptable form.
The invention extends further to the use of at least one Buchu oil extract as an active ingredient and natural preservative in the manufacture of a medicament. The topical formulation can be a therapeutic formulation. The topical formulation can be a gel or cream.
Test have been performed to test a formulation containing .25% Buchu Oil and no known preservative. The objective was to establish the preservative capability of the Buchu oil contained in the gel formulation and the results showed great preservative properties. This test was done on a formulation containing .25% Buchu Oil. The Buchu oil extract and/or Buchu preparation thus is capable of acting as natural preservative in formulations thus enabling the exclusion of parabens as preservative. The results show clearly that the requirements for antimicrobial effectiveness are met and therefore Buchu oil is a natural preservative at a concentration of .25% in our gel formulation.
This effectively means that Buchu oil can be used as a natural preservative in the cosmetic and foods industry.
As the odourless variety of the Buchu extract qualifies as a preservative, a huge spectrum of formulations can benefit from the extract since the inclusion of the extract in a formulation will no longer affect the fragrance of the product. Formulations which can benefit include cosmetic formulations, household cleaning formulations, formulations used in animals products etc.
All natural and organic formulations can benefit from including the extract as a preservative as the extract is 100% natural and offer a certified organic format option.

Claims

PATENT CLAIMS
1 . A Buchu preparation, which includes a Buchu oil extract and being adapted to be used as a natural preservative.
2. A preparation as claimed in claim 1 , in which the natural preservative is adapted to be used in the cosmetics industry and/or food industry.
3. A preparation as claimed in claim 1 or claim 2, which is adapted to act as active ingredient and natural preservative.
4. A preparation as claimed in any one of the preceding claims, which includes a synthetic preparation.
5. A preparation as claimed in any one of the preceding claims, which is a certified organic product.
6. A preparation as claimed in any one of the preceding claims, which is odourless.
7. A preparation as claimed in any one of the preceding claims, in which the Buchu oil extract is odourless.
8. A preparation as claimed in claim 7, which is adapted to increase the potential applications of the extract and Buchu preparation.
9. A preparation as claimed in any one of the preceding claims, in which the Buchu oil extract and/or Buchu preparation have various concentrations.
10. A preparation as claimed in any one of the preceding claims, in which the Buchu oil extract and/or Buchu preparation are organic or conventional extracts.
1 1 . A preparation as claimed in any one of the preceding claims, in which the Buchu oil extract and/or Buchu preparation are provided in combination with other natural extracts.
12. A preparation as claimed in any one of the preceding claims, in which the Buchu oil extract and/or Buchu preparation are effective against Aspergillus Niger.
13. A topical formulation which includes at least one Buchu oil extract as natural preservative and active ingredient.
14. A formulation as claimed in claim 13, which is a therapeutic formulation.
15. A formulation as claimed in claim 13 or claim 14, which is a gel or cream.
16. A formulation as claimed in any one of claims 13 to 15, which is effective against Aspergillus Niger.
17. A topical formulation which includes at least one active ingredient and natural preservative originating from at least one Buchu oil extract or bio- active fraction thereof in a pharmaceutically acceptable form.
18. A formulation as claimed in claim 17, which is a therapeutic formulation.
19. A formulation as claimed in claim 17 or claim 18, which is a gel or cream.
20. A formulation as claimed in any one of claims 17 to 19, which is effective against Aspergillus Niger.
21 . Use of at least one Buchu oil extract as an active ingredient and natural preservative in the manufacture of a medicament.
22. A preservative for the cosmetics and/or food industry which includes a Buchu oil extract.
23. A gel preparation which includes a Buchu preparation as a natural preservative.
24. A gel preparation which includes a Buchu preparation as described in any one of claims 1 to 12.
25. A preparation as claimed in claim 23 or claim 24, which includes the Buchu preparation of about 0.25% concentration of the gel preparation.
26. A preparation as claimed in claim 23 or claim 24, in which the Buchu preparation is sole preservative in the gel preparation.
27. A preparation which includes a low concentration of a Buchu preparation.
28. A Buchu preparation substantially as hereinbefore described.
29. A gel preparation substantially as hereinbefore described.
30. A topical preparation substantially as hereinbefore described.
31 . Use of at least one Buchu oil extract substantially as hereinbefore described.
32. A preservative substantially as hereinbefore described.
33. A preparation substantially as hereinbefore described.
PCT/IB2017/053499 2016-06-14 2017-06-13 Buchu preparation WO2017216719A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ZA2018/08521A ZA201808521B (en) 2016-06-14 2018-12-18 Buchu preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA2016/04018 2016-06-14
ZA201604018 2016-06-14

Publications (1)

Publication Number Publication Date
WO2017216719A1 true WO2017216719A1 (en) 2017-12-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2017/053499 WO2017216719A1 (en) 2016-06-14 2017-06-13 Buchu preparation

Country Status (2)

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WO (1) WO2017216719A1 (en)
ZA (1) ZA201808521B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016088029A1 (en) * 2014-12-01 2016-06-09 Cape Kingdom Nutraceuticals (Pty) Ltd Therapeutic compositions
WO2016088030A1 (en) * 2014-12-01 2016-06-09 Cape Kingdom Nutraceuticals (Pty) Ltd Buchu preparations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016088029A1 (en) * 2014-12-01 2016-06-09 Cape Kingdom Nutraceuticals (Pty) Ltd Therapeutic compositions
WO2016088030A1 (en) * 2014-12-01 2016-06-09 Cape Kingdom Nutraceuticals (Pty) Ltd Buchu preparations

Also Published As

Publication number Publication date
ZA201808521B (en) 2021-07-28

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