WO2017205811A1 - Lens oil having a narrow molecular weight distribution for intraocular lens devices - Google Patents
Lens oil having a narrow molecular weight distribution for intraocular lens devices Download PDFInfo
- Publication number
- WO2017205811A1 WO2017205811A1 PCT/US2017/034803 US2017034803W WO2017205811A1 WO 2017205811 A1 WO2017205811 A1 WO 2017205811A1 US 2017034803 W US2017034803 W US 2017034803W WO 2017205811 A1 WO2017205811 A1 WO 2017205811A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- silicone oil
- daltons
- molecular weight
- iol
- iol device
- Prior art date
Links
- 238000009826 distribution Methods 0.000 title description 7
- 229920002545 silicone oil Polymers 0.000 claims abstract description 94
- -1 dimethylsiloxane Chemical class 0.000 claims description 43
- 229920000642 polymer Polymers 0.000 claims description 34
- 239000000463 material Substances 0.000 claims description 28
- 239000002775 capsule Substances 0.000 claims description 23
- 239000012530 fluid Substances 0.000 claims description 23
- 229920001577 copolymer Polymers 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 239000003921 oil Substances 0.000 claims description 17
- 230000003287 optical effect Effects 0.000 claims description 17
- 125000003118 aryl group Chemical group 0.000 claims description 16
- 125000001188 haloalkyl group Chemical group 0.000 claims description 8
- 239000004971 Cross linker Substances 0.000 claims description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- NYMPGSQKHIOWIO-UHFFFAOYSA-N hydroxy(diphenyl)silicon Chemical class C=1C=CC=CC=1[Si](O)C1=CC=CC=C1 NYMPGSQKHIOWIO-UHFFFAOYSA-N 0.000 claims description 6
- 238000002513 implantation Methods 0.000 claims description 6
- 230000004044 response Effects 0.000 claims description 6
- 238000000194 supercritical-fluid extraction Methods 0.000 claims description 5
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 4
- 229910052710 silicon Inorganic materials 0.000 claims description 4
- 239000013590 bulk material Substances 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims 3
- 239000013013 elastic material Substances 0.000 claims 1
- 210000000695 crystalline len Anatomy 0.000 description 74
- 239000002861 polymer material Substances 0.000 description 41
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 19
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 19
- 238000000034 method Methods 0.000 description 12
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 12
- 125000004950 trifluoroalkyl group Chemical group 0.000 description 12
- 239000000835 fiber Substances 0.000 description 11
- 230000002093 peripheral effect Effects 0.000 description 11
- 230000008961 swelling Effects 0.000 description 11
- 229920002554 vinyl polymer Polymers 0.000 description 11
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 9
- 208000002177 Cataract Diseases 0.000 description 8
- 230000001886 ciliary effect Effects 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 210000003205 muscle Anatomy 0.000 description 8
- 230000008859 change Effects 0.000 description 7
- 229920001296 polysiloxane Polymers 0.000 description 7
- 239000000377 silicon dioxide Substances 0.000 description 7
- 238000001356 surgical procedure Methods 0.000 description 7
- 239000003054 catalyst Substances 0.000 description 6
- 230000004438 eyesight Effects 0.000 description 6
- 238000005227 gel permeation chromatography Methods 0.000 description 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 238000012986 modification Methods 0.000 description 6
- 230000004048 modification Effects 0.000 description 6
- 238000007789 sealing Methods 0.000 description 6
- 125000003342 alkenyl group Chemical group 0.000 description 5
- 229910021485 fumed silica Inorganic materials 0.000 description 5
- 125000000524 functional group Chemical group 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 5
- 201000010041 presbyopia Diseases 0.000 description 5
- 230000004308 accommodation Effects 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- 210000001747 pupil Anatomy 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical group C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 125000005250 alkyl acrylate group Chemical group 0.000 description 3
- 150000005840 aryl radicals Chemical class 0.000 description 3
- 235000010290 biphenyl Nutrition 0.000 description 3
- 239000004305 biphenyl Substances 0.000 description 3
- 125000006267 biphenyl group Chemical group 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000008602 contraction Effects 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- SZPIKCAXBLKNNK-UHFFFAOYSA-N dimethyl-phenoxy-phenylsilane Chemical compound C=1C=CC=CC=1[Si](C)(C)OC1=CC=CC=C1 SZPIKCAXBLKNNK-UHFFFAOYSA-N 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- GVEPBJHOBDJJJI-UHFFFAOYSA-N fluoranthene Chemical group C1=CC(C2=CC=CC=C22)=C3C2=CC=CC3=C1 GVEPBJHOBDJJJI-UHFFFAOYSA-N 0.000 description 3
- 125000005843 halogen group Chemical group 0.000 description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 3
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- WRAQQYDMVSCOTE-UHFFFAOYSA-N phenyl prop-2-enoate Chemical compound C=CC(=O)OC1=CC=CC=C1 WRAQQYDMVSCOTE-UHFFFAOYSA-N 0.000 description 3
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 3
- 229910052697 platinum Inorganic materials 0.000 description 3
- 238000001542 size-exclusion chromatography Methods 0.000 description 3
- 125000000547 substituted alkyl group Chemical group 0.000 description 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 3
- 210000004127 vitreous body Anatomy 0.000 description 3
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical group C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical group C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000002350 accommodative effect Effects 0.000 description 2
- 210000002159 anterior chamber Anatomy 0.000 description 2
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical group C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 2
- 210000001742 aqueous humor Anatomy 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical group C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- WDECIBYCCFPHNR-UHFFFAOYSA-N chrysene Chemical group C1=CC=CC2=CC=C3C4=CC=CC=C4C=CC3=C21 WDECIBYCCFPHNR-UHFFFAOYSA-N 0.000 description 2
- 239000003431 cross linking reagent Substances 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 125000004185 ester group Chemical group 0.000 description 2
- 125000005842 heteroatom Chemical group 0.000 description 2
- FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical compound C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical group C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 2
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- YNPNZTXNASCQKK-UHFFFAOYSA-N phenanthrene Chemical group C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- BBEAQIROQSPTKN-UHFFFAOYSA-N pyrene Chemical group C1=CC=C2C=CC3=CC=CC4=CC=C1C2=C43 BBEAQIROQSPTKN-UHFFFAOYSA-N 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 208000014733 refractive error Diseases 0.000 description 2
- 210000001525 retina Anatomy 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 description 1
- 125000004778 2,2-difluoroethyl group Chemical group [H]C([H])(*)C([H])(F)F 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- MEUAVGJWGDPTLF-UHFFFAOYSA-N 4-(5-benzenesulfonylamino-1-methyl-1h-benzoimidazol-2-ylmethyl)-benzamidine Chemical compound N=1C2=CC(NS(=O)(=O)C=3C=CC=CC=3)=CC=C2N(C)C=1CC1=CC=C(C(N)=N)C=C1 MEUAVGJWGDPTLF-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 102000000503 Collagen Type II Human genes 0.000 description 1
- 108010041390 Collagen Type II Proteins 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- SLGBZMMZGDRARJ-UHFFFAOYSA-N Triphenylene Chemical group C1=CC=C2C3=CC=CC=C3C3=CC=CC=C3C2=C1 SLGBZMMZGDRARJ-UHFFFAOYSA-N 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- JDPAVWAQGBGGHD-UHFFFAOYSA-N aceanthrylene Chemical group C1=CC=C2C(C=CC3=CC=C4)=C3C4=CC2=C1 JDPAVWAQGBGGHD-UHFFFAOYSA-N 0.000 description 1
- 125000004054 acenaphthylenyl group Chemical group C1(=CC2=CC=CC3=CC=CC1=C23)* 0.000 description 1
- SQFPKRNUGBRTAR-UHFFFAOYSA-N acephenanthrylene Chemical group C1=CC(C=C2)=C3C2=CC2=CC=CC=C2C3=C1 SQFPKRNUGBRTAR-UHFFFAOYSA-N 0.000 description 1
- HXGDTGSAIMULJN-UHFFFAOYSA-N acetnaphthylene Chemical group C1=CC(C=C2)=C3C2=CC=CC3=C1 HXGDTGSAIMULJN-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 150000003973 alkyl amines Chemical group 0.000 description 1
- 125000005107 alkyl diaryl silyl group Chemical group 0.000 description 1
- 125000005376 alkyl siloxane group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 150000001408 amides Chemical group 0.000 description 1
- 150000001412 amines Chemical group 0.000 description 1
- 238000010539 anionic addition polymerization reaction Methods 0.000 description 1
- 150000004982 aromatic amines Chemical group 0.000 description 1
- KNNXFYIMEYKHBZ-UHFFFAOYSA-N as-indacene Chemical group C1=CC2=CC=CC2=C2C=CC=C21 KNNXFYIMEYKHBZ-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 125000005265 dialkylamine group Chemical group 0.000 description 1
- 125000005105 dialkylarylsilyl group Chemical group 0.000 description 1
- 125000005266 diarylamine group Chemical group 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 150000002081 enamines Chemical class 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229920005570 flexible polymer Polymers 0.000 description 1
- RMBPEFMHABBEKP-UHFFFAOYSA-N fluorene Chemical group C1=CC=C2C3=C[CH]C=CC3=CC2=C1 RMBPEFMHABBEKP-UHFFFAOYSA-N 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 230000004313 glare Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 150000007857 hydrazones Chemical group 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical group 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 150000003949 imides Chemical class 0.000 description 1
- 150000002466 imines Chemical group 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000010551 living anionic polymerization reaction Methods 0.000 description 1
- 238000010550 living polymerization reaction Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 150000002825 nitriles Chemical group 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- NIHNNTQXNPWCJQ-UHFFFAOYSA-N o-biphenylenemethane Chemical group C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 description 1
- 150000002923 oximes Chemical group 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- NQFOGDIWKQWFMN-UHFFFAOYSA-N phenalene Chemical group C1=CC([CH]C=C2)=C3C2=CC=CC3=C1 NQFOGDIWKQWFMN-UHFFFAOYSA-N 0.000 description 1
- 125000003884 phenylalkyl group Chemical group 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- DIJNSQQKNIVDPV-UHFFFAOYSA-N pleiadene Chemical group C1=C2[CH]C=CC=C2C=C2C=CC=C3[C]2C1=CC=C3 DIJNSQQKNIVDPV-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- WEMQMWWWCBYPOV-UHFFFAOYSA-N s-indacene Chemical group C=1C2=CC=CC2=CC2=CC=CC2=1 WEMQMWWWCBYPOV-UHFFFAOYSA-N 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000003335 steric effect Effects 0.000 description 1
- 125000005017 substituted alkenyl group Chemical group 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 125000001174 sulfone group Chemical group 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 125000003375 sulfoxide group Chemical group 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229920001897 terpolymer Polymers 0.000 description 1
- 125000004001 thioalkyl group Chemical group 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 125000005425 toluyl group Chemical group 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 125000004665 trialkylsilyl group Chemical group 0.000 description 1
- 125000005106 triarylsilyl group Chemical group 0.000 description 1
- 125000005580 triphenylene group Chemical group 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 125000005023 xylyl group Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0834—Compounds having one or more O-Si linkage
- C07F7/0838—Compounds with one or more Si-O-Si sequences
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
- A61F2/1635—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing shape
-
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- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
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- C08G77/14—Polysiloxanes containing silicon bound to oxygen-containing groups
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- C08G77/04—Polysiloxanes
- C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
- C08G77/24—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen halogen-containing groups
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- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
- C08L83/08—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
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- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D183/00—Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon only; Coating compositions based on derivatives of such polymers
- C09D183/04—Polysiloxanes
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- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
- C10M107/00—Lubricating compositions characterised by the base-material being a macromolecular compound
- C10M107/50—Lubricating compositions characterised by the base-material being a macromolecular compound containing silicon
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- C10M171/00—Lubricating compositions characterised by purely physical criteria, e.g. containing as base-material, thickener or additive, ingredients which are characterised exclusively by their numerically specified physical properties, i.e. containing ingredients which are physically well-defined but for which the chemical nature is either unspecified or only very vaguely indicated
- C10M171/04—Specified molecular weight or molecular weight distribution
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- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/10—Block- or graft-copolymers containing polysiloxane sequences
- C08L83/12—Block- or graft-copolymers containing polysiloxane sequences containing polyether sequences
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- C10M2229/04—Siloxanes with specific structure
- C10M2229/041—Siloxanes with specific structure containing aliphatic substituents
- C10M2229/0415—Siloxanes with specific structure containing aliphatic substituents used as base material
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- C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
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- C10N2020/02—Viscosity; Viscosity index
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- C10N2030/36—Seal compatibility, e.g. with rubber
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- C10N2040/00—Specified use or application for which the lubricating composition is intended
- C10N2040/50—Medical uses
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- C10N2070/00—Specific manufacturing methods for lubricant compositions
Definitions
- the invention relates generally to lens oil having a narrow molecular weight distribution, and more particularly to lens oil suitable for use in intraocular lens devices.
- IOL intraocular lens
- IOL devices have been introduced to address ophthalmic cataracts and/or presbyopia in patients.
- multifocal lenses for IOL devices were introduced to provide vision correction at more than one distance with the goal of obviating the need for additional corrective lenses required with the monofocal lenses.
- Multifocal lenses generally have areas of varying refractive power to provide vision at multiple distances (e.g., near, intermediate and far).
- one significant disadvantage to multifocal lenses is the possibility of visual distortions, particularly in the form of glare and halos around light sources at night.
- Accommodating IOL devices have also been recently introduced for use in cataract surgery.
- Accommodating IOL devices often feature a monofocal lens configured to move and/or change shape in response to the eye's natural mechanism of accommodation, thereby providing vision correction over a broad range of distances.
- Such accommodating IOL devices may also feature a haptic system protruding from the central lens.
- Such haptic systems are typically configured to respond to the contraction and relaxation of the eye's ciliary muscles and ultimately effect changes in the central lens to provide varying diopters of power.
- Some IOL devices may also include a fluid therein, where the movement of said fluid may result in an optical power change.
- conventional fluids have been found to lead to undesirable swelling of the bulk polymer material(s) comprising the IOL device (e.g., the lens, the haptic system, etc.). There is therefore a need to develop improved fluids for use in IOL devices that minimize or eliminate the swelling of the bulk polymer material(s) of said devices.
- silicone oil is provided.
- the silicone oil can have a mean molecular weight average greater than about 20,000 Daltons and can optionally comprise, no more than about 3% to about 4% of the total silicone oil by weight, components having a molecular weight less than about 15,000 Daltons.
- an intraocular lens (IOL) device can comprise an anterior region, a posterior region, a cavity region defined between the anterior and posterior regions, and a fluid disposed in the cavity region.
- the fluid can comprise a silicone oil having a mean molecular weight average greater than about 20,000 Daltons.
- no more than about 3% to about 4% of the total silicone oil by weight is comprised of components having a molecular weight less than about 15,000 Daltons.
- an intraocular lens (IOL) device configured for implantation in a lens capsule of a patient's eye.
- the IOL device comprises a silicone oil having a mean molecular weight average greater than about 20,000 Daltons.
- the silicone oil can be purified such that no component thereof has a molecular weight less than about 5,000 Daltons.
- the IOL device can also comprise a bulk polymeric material, at least a portion of which can be in physical contact with the silicone oil.
- FIGS. 1A and IB are sectional views illustrating certain anatomical features of the human eye with an intraocular lens (IOL) device implanted in the lens capsule thereof, where the IOL device is in an accommodated and unaccommodated state, respectively.
- IOL intraocular lens
- FIG. 2 is a cut-away perspective view illustrating a simplified schematic of an
- FIG. 3 provides GPC chromatograms for various fractions of diphenyl-dimethyl siloxane obtained via supercritical fluid extraction.
- FIG. 4 provides a plot of the measured average power (in diopters) of a polymer based lens after overnight exposure to/contact with an extracted fraction of the diphenyl- dimethyl siloxane described in FIG. 3.
- FIGS. 1A-1B illustrate a simplified schematic of a human eye, and a intraocular lens (IOL) device implanted in the lens capsule thereof.
- the human eye 100 comprises three fluid-filled chambers: the anterior chamber 102, the posterior chamber 104, and the vitreous chamber 106.
- the anterior chamber 102 generally corresponds to the region between the cornea 108 and the iris 110
- the posterior chamber 104 generally corresponds to the region bounded by the iris 110, the lens capsule 112, and the zonule fibers 114 connected to the lens capsule 112.
- the anterior and posterior chambers 102, 104 contain the aqueous humor, a fluid which flows therebetween through the pupil 116 (an opening defined by the iris 110).
- the amount of light entering the eye 100 is directly related to the size of the pupil 116, which is regulated by the iris 110.
- the vitreous chamber 106 generally corresponds to the region between the lens capsule 112 and the retina 118.
- the vitreous chamber 106 contains the vitreous fluid, a transparent, colorless, gelatinous mass that is more viscous than the aqueous humor.
- much of the volume of the vitreous humor is water, it also contains cells, salts, sugars, vitrosin, a network of collagen type II fibers with glycosaminoglycan hyaluronic acid, and proteins.
- the vitreous has a viscosity that is two to four times that of pure water, giving it a gelatinous consistency.
- the vitreous humor may also have a refractive index of 1.336.
- the lens capsule 112 typically houses the eye's natural lens (not shown).
- the natural lens is an elastic, clear, crystalline membrane-like structure maintained under tension via the ciliary muscles 120 and zonule fibers 114.
- the natural lens tends to have a rounder configuration, a shape it must assume for the eye 100 to focus at a near distance. Changing the shape of the natural lens alters the focus distance of the eye. Accordingly, the eye's natural mechanism of accommodation is reflected by changes in the shape of said lens.
- the natural lens housed in the lens capsule 112 may be removed and replaced with an IOL device 122.
- Implantation of the IOL device 122 may be accomplished by first removing the natural lens housed within the lens capsule 112 through a small incision using standard surgical procedures, such as phago- emulsification. After removal of the natural lens, the IOL device 122 may then be introduced into the lens capsule 112 through the small incision.
- the IOL device 122 may be characterized as having an anterior region 124 facing the posterior chamber 104 of the eye 100.
- the anterior region 124 of the IOL device 122 may include a refractive optical element (not shown) centered about the optical axis A-A.
- the IOL device 122 may also be characterized as having a posterior region 126 coupled to the anterior region 124, with the posterior region 126 facing the vitreous chamber 106 of the eye 100.
- the IOL device 122 may additionally have a cavity region 128 defined between the anterior and posterior regions 124, 126, in which a fluid (e.g., a lens oil) may be disposed.
- a fluid e.g., a lens oil
- the fluid may be introduced into the cavity region 128 through a self-sealing valve in the IOL device 122 after implantation of the IOL device 122 in the lens capsule 112.
- the volume of the fluid contained within the IOL device 122 may be tailored according to the size of the lens capsule 112 for each patient, as would be appreciated by skilled artisans upon reading the present disclosure.
- the volume of the fluid in the cavity region 128 may be sufficient so as to permit engagement of a peripheral region 130 of the IOL device 122 with the zonule fibers 114 and ciliary muscles 120.
- the IOL device 122 changes its shape in response to the accommodative mechanisms of the eye 100.
- FIG. 1A shows the eye 100 in a generally accommodated state, as may be the case when the eye 100 is focusing on a nearby object.
- the ciliary muscles 120 contract and move in an anterior direction.
- the contraction of the ciliary muscles 120 reduces the stress exerted on the zonule fibers 114, which in turn reduces the stress exerted by the zonule fibers 114 on the lens capsule 112.
- the IOL device 122 undergoes elastic recovery and may achieve a more rounded, biconvex shape.
- FIG. IB shows the eye 100 in a generally unaccommodated state, as may be the case when the eye 100 is focusing at a distance.
- the ciliary muscles 120 relax, thereby increasing the diameter of its opening and causing the zonule fibers 114 to pull away from the optical axis A-A.
- This causes the zonule fibers 114 to radially pull on the periphery of the lens capsule 112, which causes the IOL device 122 to assume a flatter shape/geometry as compared to the accommodated state.
- the flatter shape/geometry of the lens capsule 112, and the IOL device 122 disposed therein, corresponds to a reduction in the ability to bend or refract light entering the pupil 116.
- Intraocular lens (IOL) devices suitable for implantation in the lens capsule of a patient's eye may include those described in U.S. Patent No. 9, 186,244, issued November 17, 2015; U.S. Patent Application Publication No. 2013/0053954, published on February 28, 2013; U.S. Patent Application Publication No. 2016/0030161, published on February 4, 2014; U.S. Patent Application No. 15/144,544, filed on May 2, 2016; U.S. Patent Application No. 15/144,568, filed on May 2, 2016; and International Patent Application Publication No. WO 2016/049059, published on March 31, 2016, the disclosures of which are incorporated herein for reference.
- silicone oil may be incorporated in the IOL devices described in the foregoing patent references.
- silicone oil described herein can be used in place of the fluid described in any one of these patent references.
- FIG. 2 a simplified schematic of an implantable IOL device 200 is shown in FIG. 2, according to one embodiment.
- the IOL device 200 of FIG. 2 may be implemented in combination with other devices/features/components described herein, such as those described with reference to other embodiments/aspects, and/or figures. Further, the IOL device 200 may be used in various applications and/or in permutations, which may or may not be noted in the illustrative embodiments/aspects described herein. Moreover, in some embodiments/aspects, the IOL device 200 may include more or less features/components than those shown in FIG. 2. [0029] As shown in FIG. 2, the IOL device 200 includes an anterior region 202, and a posterior region 204 coupled to the anterior region 202.
- the anterior and posterior regions 202, 204 define a cavity region 206, which may be filled with a fluid, e.g., a lens oil.
- the anterior region 204 may also include an injection port 208 configured to permit injection of the fluid into the cavity region 206.
- the injection port 208 may include a oneway, self-sealing valve.
- a separate plug (not shown) may be provided to seal off the injection port 208. While the injection port 208 is shown in FIG. 2 as being located in the anterior region 204 of the IOL device 200, the location of the injection port 208 is not critical, provided the location thereof does not impede vision.
- the anterior region 202 of the IOL device includes an optical element 210 that may be optically clear/transparent.
- the optical element 210 may be sufficiently flexible (e.g., has a sufficiently low Young's modulus) so as to respond to the accommodative mechanism of an eye.
- the optical element 210 may be sufficiently flexible so as to change its degree of curvature as the ciliary muscles of the eye relax (or contract), thus increasing (or decreasing) the tension of the zonule fibers on the lens capsule of the eye.
- the optical element 210 may be sufficiently flexible so as to change its degree of curvature in response to forces exerted upon the IOL device 200 by the vitreous chamber of the eye. This may be achieved in configurations where the posterior region 204 of the IOL device 200 may be configured to move/actuate in response to the application of an anterior force by the vitreous body during accommodation, thereby causing the fluid disposed in the cavity region 208 to exert a deforming or displacing force on the optical element 210.
- the posterior region 204 of the IOL device 200 preferably comprises a flexible material and contacts a substantial area of the posterior surface of the lens capsule.
- the optical element 210 of the IOL device 200 may comprise a first bulk polymer material.
- This first polymer material may be optically clear/transparent, biocompatible, and flexible (e.g., has a sufficiently low Young's modulus) so as to allow the optical element 210 to change its degree of curvature during accommodation.
- Suitable materials for the first polymer material may include, but are not limited to, silicone (e.g., alky siloxanes, phenyl siloxanes, fluorinated siloxanes, combinations/copolymers thereof, etc.), acrylic (e.g., alkyl acrylates, fluoracrylates, phenyl acrylate, combinations/copolymers thereof, etc.), plastic, combinations thereof, etc.
- the posterior region 204 of the IOL device 200 may have an external surface that approximates the posterior surface of an eye's lens capsule, in some aspects.
- the posterior region 204 of the IOL device 200 may be configured and/or shaped to contact a majority, a substantial, or an entirety of the posterior surface of the eye's lens capsule. In preferred aspects, this point of contact may be at and around the optical axis of the posterior surface of the eye's lens capsule.
- the posterior region 204 of the IOL device 200 may comprise a second bulk polymer material that may be optically clear/transparent, biocompatible and elastomeric.
- Suitable materials for the posterior region 204 may include, but are not limited to, silicone (e.g., alky siloxanes, phenyl siloxanes, fluorinated siloxanes, combinations/copolymers thereof, etc.), acrylic (e.g., alkyl acrylates, fluoracrylates, phenyl acrylate, combinations/copolymers thereof, etc.), plastic, combinations thereof, etc.
- the second polymer material of the posterior region 204 may be the same as the first polymer material of the anterior region 202 with regard to one or more of composition, molecular weight, porosity, Young's modulus, hydrophobicity, etc. However, in other aspects, the second polymer material of the posterior region 204 may differ from the first polymer material of the anterior region 202 with regard to one or more of composition, molecular weight, porosity, Young's modulus, hydrophobicity, etc.
- the IOL device 200 may optionally include a peripheral region configured to engage the zonule fibers of the eye.
- This peripheral region may be referred to as a haptic system, and include one or more haptic elements with shapes, configurations, and/or materials as known in the art.
- the optional peripheral region(s) may include a third bulk polymer material.
- the third bulk polymer material of the peripheral region(s) may be the same or different as the first polymer material of the anterior region 202, and/or the same or different as the second polymer material of the posterior region 204, with regard to one or more of composition, molecular weight, porosity, Young's modulus, hydrophobicity, etc.
- the aforementioned peripheral region may comprise a second cavity region (not shown) in fluidic communication with the cavity region 206 defined by the anterior and posterior regions 202, 204, thereby allowing the fluid (e.g., the lens oil) to flow therebetween.
- the fluid e.g., the lens oil
- contraction of the eye's ciliary muscles may deform the peripheral region, driving at least a portion of the fluid in the second cavity region to the cavity region defined by the anterior and posterior regions 202, 204, thereby changing the shape of the optical element 210.
- the anterior region 202 of the IOL device 200 may have a disk shape of sufficient diameter to engage the zonule fibers of an eye.
- the diameter of the anterior region 202 (along with the dimensions associated with any other component of the IOL device 200) may be tailored for each patient according to the particular size requirements of their eye.
- the anterior region, posterior region, and the peripheral region (if present) of an intraocular lens (IOL) device may each independently include a bulk polymer material.
- this bulk polymer material may include, but is not limited to, silicone (e.g., alky siloxanes, phenyl siloxanes, fluorinated siloxanes, combinations/copolymers thereof, etc.), acrylic (e.g., alkyl acrylates, fluoracrylates, phenyl acrylate, combinations/copolymers thereof, etc.), plastic, polymeric hydrogels, and/or other hydrophilic polymer materials suitable for use in an IOL device as would be appreciated by skilled artisans upon reading the present disclosure.
- silicone e.g., alky siloxanes, phenyl siloxanes, fluorinated siloxanes, combinations/copolymers thereof, etc.
- acrylic e.g., alkyl acrylates, fluoracrylates, phenyl acrylate, combinations/copolymers thereof,
- a bulk polymer material of the IOL device may include a fluorosilicone polymer.
- the fluorosilicone polymer may be a crosslinked copolymer of dialkyl, diphenyl or phenylalkyl siloxane and a fluorinated dialkyl siloxane.
- the fluorosilicone polymer may be a crosslinked copolymer of dialkyl, diphenyl or phenylalkyl siloxane and trifluoroalkyl(alkyl)siloxane, but may be a terpolymer or higher order polymer of diphenyl and/or phenylalkyl siloxane, dialkyl siloxane and trifluoroalkyl(alkyl)siloxane.
- the fluorosilicone polymer may be crosslinked copolymer of dialkyl siloxane, such as dimethyl siloxane, and trifluoroalkyl(alkyl)siloxane, such as 3,3,3-trifluoropropylmethyl siloxane.
- dialkyl siloxane such as dimethyl siloxane
- trifluoroalkyl(alkyl)siloxane such as 3,3,3-trifluoropropylmethyl siloxane.
- the ratio of dialkyl siloxane and trifluoroalkyl(alkyl)siloxane may be adjusted to tune the physical properties of the fluorosilicone polymer. For example, increasing the trifluoroalkyl(alkyl)siloxane may increase the hydrophobicity of the resulting fluorosilicone polymer.
- the fluorosilicone polymer may comprises at least about 25 mole% trifluoroalkyl(alkyl)siloxane, or about 25 mole% trifluoroalkyl(alkyl)siloxane, or about 30 mole% trifluoroalkyl(alkyl)siloxane, or about 35 mole% trifluoroalkyl(alkyl)siloxane, or about 40 mole% trifluoroalkyl(alkyl)siloxane, or about 50 mole% trifluoroalkyl(alkyl)siloxane or from about 25 mole% to about 50 mole%, or from about 25 mole% to about 40 mole% trifluoroalkyl(alkyl)siloxane.
- the aforementioned fluorosilicone polymer may be represented by formula (I):
- n and m are each independently 0 to about 500; t may be about 100 to about 1000; each R 1 may be independently alkyl or aryl; R 2 may be haloalkyl; R 3 may be alkyl or haloalkyl; R 4 and R 5 are independently alkyl, haloalkyl or aryl; and each X may be a crosslinker that links the polymer of formula (I) with a second polymer of formula (I).
- n may be about 50, or about 100, or about 125, or about 150, or about 200, or about 250, or about 300, or about 350, or about 400, or about 450, or about 500.
- m may be about 50, or about 100, or about 125, or about 150, or about 200, or about 250, or about 300, or about 350, or about 400, or about 450, or about 500.
- n may be about 100, and m may be about 150.
- t may be about 100, or about 125, or about 150, or about 200, or about 250, or about 300, or about 350, or about 400, or about 450, or about 500, or about 550, or about 600, or about 650, or about 700, or about 750, or about 800, or about 850, or about 900, or about 950, or about 1000.
- each R 1 may be alkyl. Suitable alkyl groups include, but are not limited to, Ci-C 6 alkyl groups such as methyl, ethyl, n-propyl, i-propyl, n-butyl, t-butyl, n- pentyl, n-hexyl, and the like.
- R 3 , R 4 and R 5 are each alkyl, such as defined for R 1 .
- R 1 , R 3 , R 4 and R 5 are each methyl.
- R 2 may be a haloalkyl group comprising from 1 to 3 halo (provided at least one may be fluoro) substituents.
- haloalkyl groups include, but are not limited to, fluoromethyl, 2- fluorethyl, 2,2-difluoroethyl, and 3,3,3-trifluoropropyl.
- R 2 may be 3,3,3- trifluoropropyl.
- the crosslinker, X may be a methylhydrosiloxane-dimethylsiloxane copolymer with a methyl-hydrogen content of from about 30 to about 70 mole%, in one aspect.
- the crosslinker may have a chain length ranging from about 5 to about 30 repeating Si units (i.e., degree of polymerization).
- a bulk polymeric material of the IOL device may have a degree of polymerization ranging from about 200 to about 500, or from about 300 to about 500, or about 400, or about 450.
- a bulk polymer material of the IOL device may include a fluorosilicone polymer and up to about 30 wt.% (or about 27 wt.%, or about 25 wt.%, or about 23 wt.%), or about 20 wt.%>, or from about 20 to about 30 wt.%>) of a silica component.
- This silica component may have a surface area of at least about 280 m 2 /g, or at least about 300 m 2 /g, or at least about 310 m 2 /g, or at least about 320 m 2 /g, or at least about 330 m 2 /g, or at least about 340 m 2 /g, or at least about 350 m 2 /g, in some aspects.
- the silica component may also have an average particle size of less than about 11 nanometers, in more aspects. Fumed silica having an average particle size of about 7 nanometers in diameter may be particularly suitable because the small particle size does not interfere with the wavelength of visible light and contributes to an improved optical resolution in the cured composition.
- the silica component may be fumed or "activated" silica, which has been treated with a silazane.
- the amount of silica component should be such that the polymeric material may be sufficiently reinforced, yet remains optically clear.
- Suitable silazanes and methods for carrying out the fumed silica treatment include the in situ reaction of small particle size fumed silica and are well known in the art. In such reactions, the silazane (e.g., hexamethyldisilazane) readily reacts with the hydroxyl functionalities on fumed silica, forming a trimethylsiloxane coating on the silica surface.
- the bulk polymer material of the anterior region, posterior region, and/or the peripheral region (if present) of the IOL devices disclosed herein is not limited to a fluorosilicone polymer, such as a fluorosilicone polymer of Formula I. Rather, the bulk polymer material may include other silicone materials, acrylic materials, plastic materials, and/or other biocompatible and flexible polymer materials suitable for use in an IOL device as would be appreciated by skilled artisans upon reading the present disclosure.
- a bulk polymer material of the IOL device may have a
- Young's modulus from about 10 psi to about 150 psi, or from about 50 psi to about 100 psi, or about 70 psi.
- Other physical characteristics of the polymer material can be modulated as well.
- the bulk polymer material described herein may have a tensile strength of from about 500 psi to about 1200 psi, or from about 700 psi to about 1000 psi, or about 900 psi, in particular aspects.
- the bulk polymer material described herein may have a percent elongation of from about 400% to about 1000%, or about 600%.
- the IOL comprises one or a combination of the bulk polymeric material(s) described above in which the silicone oil described herein may be fully encapsulated by the bulk polymeric material(s). In another embodiment, the IOL comprises one or a combination of the bulk polymeric material(s) described above in which the silicone oil described herein may be only partially encapsulated by the bulk polymeric material(s) with the remainder being another material that may be impermeable to the silicone oil.
- One or more of the regions of an IOL device, particularly the bulk polymer material(s) thereof, may be in contact with a fluid, e.g., a lens oil.
- a fluid e.g., a lens oil.
- conventional lens oils such as conventional silicone oils, can result in undesirable swelling of the bulk polymer material(s) associated with IOL devices.
- Embodiments disclosed herein are therefore directed to a novel lens oil suitable for use in intraocular lens (IOL) devices.
- the novel lens oil disclosed herein provides for a number of advantages owing to its narrow molecular weight distribution, and the absence/exclusion of low molecular weight components, including the reduction and/or elimination of undesirable swelling of bulk polymeric material associated with IOL devices.
- the novel lens oil disclosed herein may be a silicone oil.
- the presently disclosed silicone oil may have a mean molecular weight average sufficient to avoid any, or substantially any, swelling of bulk polymeric material associated with the components of IOL devices.
- the silicone oil may have a mean molecular weight average of about 20,000 Daltons or greater, according to one aspect.
- the silicone oil may have a mean molecular weight in a range from about 20,000 Daltons to about 400,000 Daltons.
- the silicone oil may have a mean molecular weight of at least about 20,000 Daltons, at least about 25,000 Daltons, at least about 30,000 Daltons, at least about 35,000 Daltons, at least about 40,000 Daltons, at least about 45,000 Daltons, at least about 50,000 Daltons, at least about 55,000 Daltons, at least about 60,000 Daltons, at least about 65,000 Daltons, at least about 70,000 Daltons, at least about 75,000 Daltons, at least about 80,000 Daltons, at least about 85,000 Daltons, at least about 90,000 Daltons, at least about 95,000 Daltons, at least about 100,000 Daltons, at least about 105,000 Daltons, at least about 110,000 Daltons, at least about 115,000 Daltons, at least about 120,000 Daltons, at least about 125,000 Daltons, at least about 130,000 Daltons, at least about 135,000 Daltons, at least about 140,000 Daltons, at least about 145,000 Daltons, at least about 150,000 Daltons, at least about 155,000 Daltons, at least about 160,000 Daltons, at least
- the silicone oil may have a mean molecular weight within a range that includes any two of the foregoing values.
- the presently disclosed silicone oil may have a minimal concentration of low molecular weight components to prevent any, or substantially any, swelling of bulk polymeric material associated with IOL devices.
- 0% to about 4% of the total silicone oil by weight may be comprised of components having a molecular weight less than about 15,000 Daltons.
- no more than about 4% of the total silicone oil by weight may be comprised of components having a molecular weight less than about 15,000 Daltons.
- the silicone oil may comprise no more than about 3 wt.%, no more than about 2 wt.%, no more than about 1 wt.%, no more than about 0.05 wt.%, or no more than about 0.005 wt.% of components having a molecular weight less than about 15,000 Daltons.
- the total silicone oil by weight may be comprised of components having a molecular weight greater than about 5,000 Daltons.
- the silicone oil does not include any component having a molecular weight of about 5,000 Daltons or less.
- the inclusion of components having a molecular weight of about 1,000 Daltons, or about 2,000 Daltons, or about 3,000 Daltons, or about 4,000 Daltons, or even about 5,000 Daltons in the silicone oil may, in certain instances, lead to unfavorable swelling of the bulk polymeric material(s) associated with the IOL devices described herein.
- no more than about 3% to about 4% of the total silicone oil by weight may be comprised of components having a molecular weight less than about 15,000 Daltons.
- no components in the silicone oil have a molecular weight less than 5,000 Daltons.
- the presently disclosed silicone oil may further have a narrow molecular weight distribution, and thus a low polydispersity index (PDI), in various embodiments.
- the silicone oil may have a PDI of about 1.5 or greater, in one exemplary aspect.
- the silicone oil may have a PDI of about 2.4.
- the presently disclosed silicone oil may have a viscosity in a range from about
- the viscosity of the presently disclosed silicone oil may be about 5,000 mm 2 /s at 25 °C or greater.
- the presently disclosed silicone oil may have a viscosity in a range from about 4,000 mm 2 /s at 25 °C to about 15,000 mm 2 /s at 25 °C.
- the silicone oil may have a viscosity of about 4,000 mm 2 /s at 25 °C, about 4,500 mm 2 /s at 25 °C, about 5,000 mm 2 /s at 25 °C, about 5,500 mm 2 /s at 25 °C, about 6,000 mm 2 /s at 25 °C, about 6,500 mm 2 /s at 25 °C, about 7,000 mm 2 /s at 25 °C, about 7,500 mm 2 /s at 25 °C, about 8,000 mm 2 /s at 25 °C, about 8,500 mm 2 /s at 25 °C, about 9,000 mm 2 /s at 25 °C, about 9,500 mm 2 /s at 25 °C, about
- the presently disclosed silicone oil may have a viscosity greater than about 15,000 mm 2 /s at 25 °C.
- the silicone oil may have a viscosity of about 20,000 mm 2 /s at 25 °C, about 25,000 mm 2 /s at 25 °C, about 30,000 mm 2 /s at 25 °C, about 35,000 mm 2 /s at 25 °C, about 40,000 mm 2 /s at 25 °C, about 45,000 mm 2 /s at 25 °C, about 50,000 mm 2 /s at 25 °C, about 55,000 mm 2 /s at 25 °C, about 60,000 mm 2 /s at 25 °C, about 65,000 mm 2 /s at 25 °C, about 70,000 mm 2 /s at 25 °C, about 75,000 mm 2 /s at 25 °C, about 80,000 mm 2 /s at 25 °C, about 85,000
- the presently disclosed silicone oil may be substantially index-matched to the bulk material(s) of IOL devices.
- an index- matched material refers to a material whose index of refraction may be about equal to, or closely approximates, the index of refraction of another material.
- the presently disclosed silicone oil may have an index of refraction in a range from about 1.40 to about 1.60. In particular aspects, the presently disclosed silicone oil may have an index of refraction of about 1.49.
- the presently disclosed silicone oil may comprise an aryl siloxane and an alkyl siloxane.
- Suitable aryl groups for the aryl siloxane may include, but are not limited to, phenyl, naphthyl, toluyl, xylyl, and the like.
- Suitable alky groups may include, but are not limited to, methyl, ethyl, n-propyl, i-propyl, n-butyl, t-butyl, n-pentyl, n-hyexyl, and the like.
- the aryl groups of the aryl siloxane may help prevent diffusion of the silicone oil through the bulk polymer material(s) of IOL device due to steric effects.
- the silicone oil may comprise a greater percentage of aryl siloxane as compared to alky siloxane in some aspects.
- the silicone oil may comprise a copolymer represented by formula (II):
- each of n and m may be independently an integer ranging from 0 to about 500; each R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 may be independently hydrogen, alkyl, alkenyl, or aryl, optionally substituted analogs thereof, or other suitable saturated or unsaturated functional group as would be apparent to skilled artisans upon reading the present disclosure.
- n may be about 50, or about 100, or about 125, or about 150, or about 200, or about 250, or about 300, or about 350, or about 400, or about 450, or about 500.
- m may be about 50, or about 100, or about 125, or about 150, or about 200, or about 250, or about 300, or about 350, or about 400, or about 450, or about 500.
- n and/or m may be integers greater than about 500.
- n and m may correspond to integers designated a repeating siloxane unit, where n and m may be independently selected to achieve a desired molecular weight of the resulting silicone copolymer, and/or selected to achieve a desired ratio of the particular siloxane polymer units to which n and m correspond.
- alky may refer to a straight or branched hydrocarbon chain radical consisting solely of carbon and hydrogen atoms, which may be saturated or unsaturated (i.e., contains one or more double and/or triple bonds), having from one to twenty carbon atoms (C1-C20 alkyl), and which may be attached to the rest of the molecule by a single bond.
- Suitable alkyl groups may include, but are not limited to methyl, ethyl, n- propyl, i-propyl, n-butyl, t-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, etc.
- alkenyl may refer to a linear or branched hydrocarbon radical having from one to twenty carbon atoms, and containing at least one double bond. Suitable alkenyl groups may include, but are not limited to, vinyl, 2-propenyl, crotyl, 2-isopentenyl, etc.
- aryl may refer to a hydrocarbon ring system radical comprising hydrogen, 6 to 18 carbon atoms and at least one aromatic ring.
- the aryl radical may be a monocyclic, bicyclic, tricyclic or tetracyclic ring system, which may include fused or bridged ring systems.
- Aryl radicals include, but are not limited to, aryl radicals derived from aceanthrylene, acenaphthylene, acephenanthrylene, anthracene, azulene, benzene, chrysene, fluoranthene, fluorene, as-indacene, s-indacene, indane, indene, naphthalene, phenalene, phenanthrene, pleiadene, pyrene, and triphenylene.
- the term "optionally substituted” may refer to any of the aforementioned functional groups (e.g., alkyl, alkylene, aryl, etc.) where at least one hydrogen atom may be replaced by a bond to a non-hydrogen atoms such as, but not limited to: a halogen atom (e.g., F, CI, Br, and I); an oxygen atom in groups such as hydroxyl groups, alkoxy groups, and ester groups; a sulfur atom in groups such as thiol groups, thioalkyl groups, sulfone groups, sulfonyl groups, and sulfoxide groups; a nitrogen atom in groups such as amines, amides, alkylamines, dialkylamines, arylamines, alkylarylamines, diarylamines, N- oxides, imides, and enamines; a silicon atom in groups such as trialkylsilyl groups
- Optionally substituted may also mean any of the above groups in which one or more hydrogen atoms are replaced by a higher-order bond (e.g., a double- or triple-bond) to a heteroatom such as oxygen in oxo, carbonyl, carboxyl, and ester groups; and nitrogen in groups such as imines, oximes, hydrazones, and nitriles.
- a higher-order bond e.g., a double- or triple-bond
- nitrogen in groups such as imines, oximes, hydrazones, and nitriles.
- R 1 and/or R 10 may be hydrogen. In more aspects, each of R 1 and/or R 10 may be hydrogen.
- R 10 may be independently alkyl or an optionally substituted alkyl. In yet more aspects, each of R 1 and R 10 may be independently aryl or an optionally substituted analog thereof.
- R 1 and/or R 10 may be independently alkenyl or an optionally substituted alkenyl.
- R 1 and/or R 10 may be a reactive functional group (e.g., an unsaturated alkenyl) configured to couple (e.g., via a crosslinking reaction) to a reactive group of another polymer, which may also comprise a copolymer of formula (II).
- R 1 and/or R 10 may be a reactive functional group may be especially advantageous for use in an IOL device.
- lens oil e.g., comprising copolymer chains of formula (II) and/or other suitable polymer chains
- an opening e.g., valve, port, puncture wound, etc.
- the inclusion of polymer chains having at least one reactive group (per chain) allows at least some of the polymer chains to be crosslinked with one another, and thereby form a gel, within the IOL device.
- these polymer chains having at least one reactive group (per chain) can participate in the formation of a polymerized sealing plug, and do not interfere with the sealing, by virtue of any residue of the silicone oil becoming crosslinked into the polymer cure of the plug.
- the silicone oil within the IOL device may be a lightly crosslinked gel, whose unreacted polymer chains do not diffuse through the bulk polymer material of the IOL device.
- R 1 and/or R 10 may be vinyl.
- the addition of vinyl terminated reactive silicone copolymers of formula (II) in the cavity region of the IOL device may be beneficial as said copolymers are stable (i.e., do not degrade when exposed to the environment of a human eye), can form a crosslinked gel within the IOL device, and do not interfere, and may participate, with the aforementioned sealing process of the IOL device.
- vinyl terminated reactive silicone polymers of formula (II) may be cured via combination with a suitable crosslinking agent and a curing agent to form the desired, resulting silicone oil, i.e., a silicone oil that does not pass into the free volume of the bulk polymer material of the IOL device and cause swelling thereof.
- R 1 and/or R 10 may include a reactive terminal end group other than vinyl in certain aspects. Further, in other aspects, R 1 and/or R 10 may be a non-reactive group (e.g., a saturated functional group) that does not participate in polymerization.
- a non-reactive group e.g., a saturated functional group
- R 1 and/or R 10 may include a methylhydrosiloxane- dimethylsiloxane copolymer with a methyl-hydrogen content ranging from about 30 to about 70 mole%.
- the methylhydrosiloxane-dimethylsiloxane copolymer may have chain length of about 5 to about 30 repeating Si units (i.e., degree of polymerization).
- each of R 2 , R 3 , R 8 , and R 9 may be independently alkyl, aryl, or optionally substituted analogs thereof. In more aspects, each of R 2 , R 3 , R 8 , and R 9 may be independently alkyl or an optionally substituted alkyl. In one such aspect, each of R 2 , R 3 , R 8 , and R 9 may be methyl.
- each of R 4 and R 5 may be independently alky, aryl, or optionally substituted analogs thereof. In various aspects, each of R 4 and R 5 may be independently alkyl or an optionally substituted alkyl. In one such aspect, R 4 and/or R 5 may be methyl.
- each of R 6 and R 7 may be independently alky, aryl, or substituted analogs thereof. In various aspects, each of R 6 and R 7 may be independently aryl or an optionally substituted aryl. In one aspect, R 6 and/or R 7 may be phenyl. In more aspects, R 6 may be alkyl and R 7 may be aryl. In one such aspect, R 6 may be methyl and R 7 may be phenyl.
- each of R 1 and R 10 may be vinyl; each of R 2 , R 3 , R 4 , R 5 ,
- R 8 , and R 9 may be methyl; and each of R 6 and R 7 may be phenyl.
- R 1 and R 10 may be vinyl; each of R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , and R 9 may be methyl; and R 7 may be phenyl.
- the presently disclosed silicone oil may comprise dimethylsiloxane and diphenylsiloxane. Moreover, the silicone oil may comprise dimethylsiloxane in an amount ranging from about 20 mole% to about 25 mole% (preferably about 22 mole% to about 25 mole%), and diphenylsiloxane in an amount ranging from about 80 mole% to about 75 mole% (preferably about 78 mole% to about 75 mole%) in various aspects.
- the presently disclosed silicone oil may comprise dimethylsiloxane (about 0 mole% to about 100 mole%) and methylphenylsiloxane (about 0 mole% to about 100 mole%).
- the presently disclosed silicone oil may be manufactured using known synthesis and polymer chemistry techniques.
- methods of making the silicone oil may include anionic addition polymerization, living polymerization, living anionic polymerization, etc.
- a method of making the presently disclosed silicone oil may comprise: (a) providing vinyl terminated/end-blocked diphenylsiloxane- dimethyl siloxane copolymers to obtain a polymer composition; (b) adding a crosslinking agent and a curing agent to the polymer composition; and (c) curing the polymer composition to obtain a diphenylsiloxane-dimethylsiloxane silicone oil.
- the vinyl terminated diphenylsiloxane- dimethylsiloxane may be synthesized using known methods from commercially available starting materials or purchased from commercial sources.
- Suitable vinyl endblockers include, but are not limited to, a vinyl-endblocked dimethyl siloxane oligomer.
- the resulting oil may also be lightly crosslinked in some aspects, having less than about 5 parts per hundred (pph) crosslinker, or less than about 4 pph, or less than about 2 pph, or less than about 1 pph crosslinker, etc.
- the curing step may include addition of a platinum catalyst.
- the platinum group metal catalyst may be any of the compatible platinum group metal-containing catalysts known to catalyze the addition of silicone-hydrogen atoms to silicon-bonded vinyl radicals.
- Platinum group metal-containing catalysts may be any of the known forms which are compatible, such as platinic chloride, salts of platinum, chloroplatinic acid and various complexes, for example, silicone complexes with platinum metal-containing groups.
- the platinum group metal-containing catalyst may be used in any catalytic quantity, such as in an amount sufficient to provide at least about 0.1 ppm weight of platinum group metal (as elemental metal) based on the total weight of the composition. In certain aspects, at least about 10 ppm, or at least about 20 ppm, or at least 30 ppm, or at least about 40 ppm by weight of platinum catalyst may be used.
- the presently disclosed silicone oil may be purified using known extraction/fractionation techniques so as to remove low molecular weight components, in preferred embodiments.
- the silicone oil may be purified via supercritical fluid extraction using supercritical C02, propane, ethane, ethylene, combinations thereof, and/or other suitable eluting solvent as would be appreciated by skilled artisans upon reading the present disclosure.
- SEC size exclusion chromatography
- GPC gel permeation chromatography
- FIG. 3 provides GPC chromatograms of detector response (au) versus retention time (minutes) for various fractions of diphenyl-dimethyl siloxane obtained via supercritical fluid extraction.
- a UV/VIS detector (256 nm) was used to detect the fractions. Based on a comparison to a GPC calibration curve, fraction 5 indicated in FIG.
- 3 corresponded to the desired narrow molecular weight distribution, and minimal amount of low molecular weight components disclosed herein (e.g., no more than about 3 wt.% to about 4 wt.% of any component having a molecular weight less than about 15,000 Daltons, and more preferably no components having a molecular weight less than about 5,000 Daltons).
- Fraction 5 was further subject to a swell study to determine the degree to which a bulk polymer material of known weight and dimensions swelled when in contact therewith.
- a swell study included preparing a lens (e.g., having a 7 mm shell) comprised of a bulk polymer material, contacting the silicone oil (i.e., fraction 5) to the bulk polymer material, measuring the dimensions and weight of the bulk polymer material over time, and comparing the measurements to the original dimensions and weight of the bulk polymer material. Such comparison provides an indication of how much the polymer material "swelled" (i.e., how much its dimensions and weight increased).
- FIG. 4 provides further verification that fraction 5 resulted in no swelling of the polymer lens material to which it was exposed.
- fraction 5 excludes substantially all low molecular weight components that typically diffuse into the bulk polymer material of an IOL device and which lead to undesirable swelling of the bulk polymer material, as well as undesirable changes in the optical properties of the IOL device. For instance, as shown in FIG. 4, the measurement of the average power (in diopters) of the polymer based lens did not change upon overnight exposure to/contact with fraction 5.
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Abstract
A silicone oil having a mean molecular weight average greater than about 20,000 Daltons, with no more than about 3% to about 4% of the total silicone oil by weight being comprised of components having a molecular weight less than about 15,000 Daltons. In some embodiments, the silicone oil is used in intraocular lens devices.
Description
LENS OIL HAVING A NARROW MOLECULAR WEIGHT DISTRIBUTION FOR
INTRAOCULAR LENS DEVICES
CROSS-REFERENCE TO RELATED APPLICATION
[0001] The present application claims priority to U.S. Provisional Patent Application No. 62/342,590, entitled "Lens Oil Having a Narrow Molecular Weight Distribution For Intraocular Lens Devices," filed May 27, 2016, the entire contents of which are incorporated by reference into this application.
FIELD OF THE INVENTION
[0002] The invention relates generally to lens oil having a narrow molecular weight distribution, and more particularly to lens oil suitable for use in intraocular lens devices.
BACKGROUND
[0003] Surgical procedures on the eye have been on the rise as technological advances permit for sophisticated interventions to address a wide variety of ophthalmic conditions. Patient acceptance has increased over the last twenty years, as such procedures have proven to be generally safe and produce results that significantly improve patient quality of life.
[0004] Cataract surgery remains one of the most common surgical procedures, with over
16 million cataract procedures being performed worldwide. It is expected that this number will continue to rise as average life expectancies continue to increase. Cataracts are typically treated by removing the crystalline lens from the eye and implanting an intraocular lens ("IOL") in its place. Conventional IOL devices typically provide vision correction at only a single distance via a monofocal lens, and thus fail to correct for presbyopia. Accordingly, while patients who undergo a standard IOL implantation no longer experience clouding from cataracts, they are unable to accommodate, or change focus from near to far, from far to near, and to distances in between, and still require use of corrective glasses.
[0005] Surgeries to correct refractive errors of the eye have also become extremely common, of which LASIK enjoys substantial popularity with over 700,000 procedures being performed per year. Given the high prevalence of refractive errors and the relative safety and
effectiveness of this procedure, more and more people are expected to turn to LASIK or other surgical procedures over conventional eyeglasses or contact lenses. Despite the success of LASIK in treating myopia, there remains an unmet need for an effective surgical intervention to correct for presbyopia, which cannot be treated by conventional LASIK procedures.
[0006] As nearly every cataract patient also suffers from presbyopia, there is convergence of market demands for the treatment of both these conditions. Various modifications of IOL devices have been introduced to address ophthalmic cataracts and/or presbyopia in patients. For instance, multifocal lenses for IOL devices were introduced to provide vision correction at more than one distance with the goal of obviating the need for additional corrective lenses required with the monofocal lenses. Multifocal lenses generally have areas of varying refractive power to provide vision at multiple distances (e.g., near, intermediate and far). However, one significant disadvantage to multifocal lenses is the possibility of visual distortions, particularly in the form of glare and halos around light sources at night.
[0007] Accommodating IOL devices have also been recently introduced for use in cataract surgery. Accommodating IOL devices often feature a monofocal lens configured to move and/or change shape in response to the eye's natural mechanism of accommodation, thereby providing vision correction over a broad range of distances. Such accommodating IOL devices may also feature a haptic system protruding from the central lens. Such haptic systems are typically configured to respond to the contraction and relaxation of the eye's ciliary muscles and ultimately effect changes in the central lens to provide varying diopters of power.
[0008] Some IOL devices may also include a fluid therein, where the movement of said fluid may result in an optical power change. However, conventional fluids have been found to lead to undesirable swelling of the bulk polymer material(s) comprising the IOL device (e.g., the lens, the haptic system, etc.). There is therefore a need to develop improved fluids for use in IOL devices that minimize or eliminate the swelling of the bulk polymer material(s) of said devices.
BRIEF SUMMARY
[0009] In one embodiment, silicone oil is provided. The silicone oil can have a mean molecular weight average greater than about 20,000 Daltons and can optionally comprise, no more than about 3% to about 4% of the total silicone oil by weight, components having a molecular weight less than about 15,000 Daltons.
[0010] In another embodiment, an intraocular lens (IOL) device is provided. The IOL device can comprise an anterior region, a posterior region, a cavity region defined between the anterior and posterior regions, and a fluid disposed in the cavity region. The fluid can comprise a silicone oil having a mean molecular weight average greater than about 20,000 Daltons. Optionally, no more than about 3% to about 4% of the total silicone oil by weight is comprised of components having a molecular weight less than about 15,000 Daltons.
[0011] In yet another embodiment, an intraocular lens (IOL) device configured for implantation in a lens capsule of a patient's eye is provided. The IOL device comprises a silicone oil having a mean molecular weight average greater than about 20,000 Daltons. The silicone oil can be purified such that no component thereof has a molecular weight less than about 5,000 Daltons. The IOL device can also comprise a bulk polymeric material, at least a portion of which can be in physical contact with the silicone oil.
[0012] Other objects, features and advantages of the described preferred embodiments will become apparent to those skilled in the art from the following detailed description. It is to be understood, however, that the detailed description and specific examples, while indicating preferred embodiments of the present invention, are given by way of illustration and not limitation. Many changes and modifications within the scope of the present invention may be made without departing from the spirit thereof, and the invention includes all such modifications.
BRIEF DESCRIPTION OF THE DRAWINGS
[0013] Preferred and non-limiting embodiments of the invention may be more readily understood by referring to the accompanying drawings in which:
[0014] FIGS. 1A and IB are sectional views illustrating certain anatomical features of the human eye with an intraocular lens (IOL) device implanted in the lens capsule thereof, where the IOL device is in an accommodated and unaccommodated state, respectively.
[0015] FIG. 2 is a cut-away perspective view illustrating a simplified schematic of an
IOL device.
[0016] FIG. 3 provides GPC chromatograms for various fractions of diphenyl-dimethyl siloxane obtained via supercritical fluid extraction.
[0017] FIG. 4 provides a plot of the measured average power (in diopters) of a polymer based lens after overnight exposure to/contact with an extracted fraction of the diphenyl- dimethyl siloxane described in FIG. 3.
DETAILED DESCRIPTION OF THE PREFERRED EMB ODEVIENT S
[0018] Specific, non-limiting embodiments of the present invention will now be described with reference to the drawings. It should be understood that particular features and aspects of any embodiment disclosed herein may be used and/or combined with particular features and aspects of any other embodiment disclosed herein. It should also be understood that such embodiments are by way of example and are merely illustrative of but a small number of embodiments within the scope of the present invention. Various changes and modifications obvious to one skilled in the art to which the present invention pertains are deemed to be within the spirit, scope and contemplation of the present invention as further defined in the appended claims.
[0019] Unless the context requires otherwise, throughout the present specification and claims, the word "comprise" and variations thereof, such as, "comprises" and "comprising" are to be construed in an open, inclusive sense, that is as "including, but not limited to." The use of all examples, illustrations, and/or exemplary language ("e.g.", "such as", etc.) herein does not
impose a limitation on the scope of the invention unless otherwise specified. Furthermore, recitation of numeric ranges of values throughout the specification is intended to serve as a shorthand notation of referring individually to each separate value falling within the range inclusive of the values defining the range, and each separate value is incorporated in the specification as it were individually recited herein. Additionally, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.
Implanted Intraocular Lens Device
[0020] FIGS. 1A-1B illustrate a simplified schematic of a human eye, and a intraocular lens (IOL) device implanted in the lens capsule thereof. As shown in FIGS. 1A-1B, the human eye 100 comprises three fluid-filled chambers: the anterior chamber 102, the posterior chamber 104, and the vitreous chamber 106. The anterior chamber 102 generally corresponds to the region between the cornea 108 and the iris 110, whereas the posterior chamber 104 generally corresponds to the region bounded by the iris 110, the lens capsule 112, and the zonule fibers 114 connected to the lens capsule 112. The anterior and posterior chambers 102, 104 contain the aqueous humor, a fluid which flows therebetween through the pupil 116 (an opening defined by the iris 110). Light enters the eye 100 through the pupil 116 and travels along the visual axis A- A, ultimately striking the retina 118 to produce vision. The amount of light entering the eye 100 is directly related to the size of the pupil 116, which is regulated by the iris 110.
[0021] The vitreous chamber 106 generally corresponds to the region between the lens capsule 112 and the retina 118. The vitreous chamber 106 contains the vitreous fluid, a transparent, colorless, gelatinous mass that is more viscous than the aqueous humor. Although much of the volume of the vitreous humor is water, it also contains cells, salts, sugars, vitrosin, a network of collagen type II fibers with glycosaminoglycan hyaluronic acid, and proteins. Preferably, the vitreous has a viscosity that is two to four times that of pure water, giving it a gelatinous consistency. The vitreous humor may also have a refractive index of 1.336.
[0022] The lens capsule 112 typically houses the eye's natural lens (not shown). The natural lens is an elastic, clear, crystalline membrane-like structure maintained under tension via the ciliary muscles 120 and zonule fibers 114. As a result, the natural lens tends to have a
rounder configuration, a shape it must assume for the eye 100 to focus at a near distance. Changing the shape of the natural lens alters the focus distance of the eye. Accordingly, the eye's natural mechanism of accommodation is reflected by changes in the shape of said lens.
[0023] To correct for ophthalmic cataracts and/or presbyopia, the natural lens housed in the lens capsule 112 may be removed and replaced with an IOL device 122. Implantation of the IOL device 122 may be accomplished by first removing the natural lens housed within the lens capsule 112 through a small incision using standard surgical procedures, such as phago- emulsification. After removal of the natural lens, the IOL device 122 may then be introduced into the lens capsule 112 through the small incision.
[0024] As shown in the non-limiting embodiment of FIGS. 1A-1B, the IOL device 122 may be characterized as having an anterior region 124 facing the posterior chamber 104 of the eye 100. The anterior region 124 of the IOL device 122 may include a refractive optical element (not shown) centered about the optical axis A-A. The IOL device 122 may also be characterized as having a posterior region 126 coupled to the anterior region 124, with the posterior region 126 facing the vitreous chamber 106 of the eye 100. The IOL device 122 may additionally have a cavity region 128 defined between the anterior and posterior regions 124, 126, in which a fluid (e.g., a lens oil) may be disposed. In some aspects, the fluid may be introduced into the cavity region 128 through a self-sealing valve in the IOL device 122 after implantation of the IOL device 122 in the lens capsule 112. The volume of the fluid contained within the IOL device 122 may be tailored according to the size of the lens capsule 112 for each patient, as would be appreciated by skilled artisans upon reading the present disclosure. In preferred aspects, the volume of the fluid in the cavity region 128 may be sufficient so as to permit engagement of a peripheral region 130 of the IOL device 122 with the zonule fibers 114 and ciliary muscles 120.
[0025] Similar to the natural lens, the IOL device 122 changes its shape in response to the accommodative mechanisms of the eye 100. For instance, FIG. 1A shows the eye 100 in a generally accommodated state, as may be the case when the eye 100 is focusing on a nearby object. In such an accommodated state, the ciliary muscles 120 contract and move in an anterior direction. The contraction of the ciliary muscles 120 reduces the stress exerted on the zonule fibers 114, which in turn reduces the stress exerted by the zonule fibers 114 on the lens
capsule 112. As a result, the IOL device 122 undergoes elastic recovery and may achieve a more rounded, biconvex shape.
[0026] FIG. IB shows the eye 100 in a generally unaccommodated state, as may be the case when the eye 100 is focusing at a distance. In such an unaccommodated state, the ciliary muscles 120 relax, thereby increasing the diameter of its opening and causing the zonule fibers 114 to pull away from the optical axis A-A. This, in turn, causes the zonule fibers 114 to radially pull on the periphery of the lens capsule 112, which causes the IOL device 122 to assume a flatter shape/geometry as compared to the accommodated state. The flatter shape/geometry of the lens capsule 112, and the IOL device 122 disposed therein, corresponds to a reduction in the ability to bend or refract light entering the pupil 116.
Intraocular Lens Device
[0027] Intraocular lens (IOL) devices suitable for implantation in the lens capsule of a patient's eye may include those described in U.S. Patent No. 9, 186,244, issued November 17, 2015; U.S. Patent Application Publication No. 2013/0053954, published on February 28, 2013; U.S. Patent Application Publication No. 2016/0030161, published on February 4, 2014; U.S. Patent Application No. 15/144,544, filed on May 2, 2016; U.S. Patent Application No. 15/144,568, filed on May 2, 2016; and International Patent Application Publication No. WO 2016/049059, published on March 31, 2016, the disclosures of which are incorporated herein for reference. It is understood that the silicone oil may be incorporated in the IOL devices described in the foregoing patent references. For example, the silicone oil described herein can be used in place of the fluid described in any one of these patent references. However, for illustrative purposes only, a simplified schematic of an implantable IOL device 200 is shown in FIG. 2, according to one embodiment.
[0028] The IOL device 200 of FIG. 2 may be implemented in combination with other devices/features/components described herein, such as those described with reference to other embodiments/aspects, and/or figures. Further, the IOL device 200 may be used in various applications and/or in permutations, which may or may not be noted in the illustrative embodiments/aspects described herein. Moreover, in some embodiments/aspects, the IOL device 200 may include more or less features/components than those shown in FIG. 2.
[0029] As shown in FIG. 2, the IOL device 200 includes an anterior region 202, and a posterior region 204 coupled to the anterior region 202. The anterior and posterior regions 202, 204 define a cavity region 206, which may be filled with a fluid, e.g., a lens oil. The anterior region 204 may also include an injection port 208 configured to permit injection of the fluid into the cavity region 206. In various aspects, the injection port 208 may include a oneway, self-sealing valve. In other aspects, a separate plug (not shown) may be provided to seal off the injection port 208. While the injection port 208 is shown in FIG. 2 as being located in the anterior region 204 of the IOL device 200, the location of the injection port 208 is not critical, provided the location thereof does not impede vision.
[0030] As also shown in FIG. 2, the anterior region 202 of the IOL device includes an optical element 210 that may be optically clear/transparent. Preferably, the optical element 210 may be sufficiently flexible (e.g., has a sufficiently low Young's modulus) so as to respond to the accommodative mechanism of an eye. In particular aspects, the optical element 210 may be sufficiently flexible so as to change its degree of curvature as the ciliary muscles of the eye relax (or contract), thus increasing (or decreasing) the tension of the zonule fibers on the lens capsule of the eye.
[0031] In additional aspects, the optical element 210 may be sufficiently flexible so as to change its degree of curvature in response to forces exerted upon the IOL device 200 by the vitreous chamber of the eye. This may be achieved in configurations where the posterior region 204 of the IOL device 200 may be configured to move/actuate in response to the application of an anterior force by the vitreous body during accommodation, thereby causing the fluid disposed in the cavity region 208 to exert a deforming or displacing force on the optical element 210. To effectuate the transfer of the anterior movements of the vitreous chamber upon the lens capsule of the eye, the posterior region 204 of the IOL device 200 preferably comprises a flexible material and contacts a substantial area of the posterior surface of the lens capsule.
[0032] In various aspects, the optical element 210 of the IOL device 200 may comprise a first bulk polymer material. This first polymer material may be optically clear/transparent, biocompatible, and flexible (e.g., has a sufficiently low Young's modulus) so as to allow the optical element 210 to change its degree of curvature during accommodation. Suitable materials
for the first polymer material may include, but are not limited to, silicone (e.g., alky siloxanes, phenyl siloxanes, fluorinated siloxanes, combinations/copolymers thereof, etc.), acrylic (e.g., alkyl acrylates, fluoracrylates, phenyl acrylate, combinations/copolymers thereof, etc.), plastic, combinations thereof, etc.
[0033] As additionally shown in FIG. 2, the posterior region 204 of the IOL device 200 may have an external surface that approximates the posterior surface of an eye's lens capsule, in some aspects. In more aspects, the posterior region 204 of the IOL device 200 may be configured and/or shaped to contact a majority, a substantial, or an entirety of the posterior surface of the eye's lens capsule. In preferred aspects, this point of contact may be at and around the optical axis of the posterior surface of the eye's lens capsule.
[0034] In yet further aspects, the posterior region 204 of the IOL device 200 may comprise a second bulk polymer material that may be optically clear/transparent, biocompatible and elastomeric. Suitable materials for the posterior region 204 may include, but are not limited to, silicone (e.g., alky siloxanes, phenyl siloxanes, fluorinated siloxanes, combinations/copolymers thereof, etc.), acrylic (e.g., alkyl acrylates, fluoracrylates, phenyl acrylate, combinations/copolymers thereof, etc.), plastic, combinations thereof, etc. In one particular aspect, the second polymer material of the posterior region 204 may be the same as the first polymer material of the anterior region 202 with regard to one or more of composition, molecular weight, porosity, Young's modulus, hydrophobicity, etc. However, in other aspects, the second polymer material of the posterior region 204 may differ from the first polymer material of the anterior region 202 with regard to one or more of composition, molecular weight, porosity, Young's modulus, hydrophobicity, etc.
[0035] While not shown in FIG. 2, the IOL device 200 may optionally include a peripheral region configured to engage the zonule fibers of the eye. This peripheral region may be referred to as a haptic system, and include one or more haptic elements with shapes, configurations, and/or materials as known in the art. In one exemplary aspect, the optional peripheral region(s) may include a third bulk polymer material. The third bulk polymer material of the peripheral region(s) may be the same or different as the first polymer material of the anterior region 202, and/or the same or different as the second polymer material of the posterior
region 204, with regard to one or more of composition, molecular weight, porosity, Young's modulus, hydrophobicity, etc.
[0036] In yet more aspects, the aforementioned peripheral region may comprise a second cavity region (not shown) in fluidic communication with the cavity region 206 defined by the anterior and posterior regions 202, 204, thereby allowing the fluid (e.g., the lens oil) to flow therebetween. For instance, contraction of the eye's ciliary muscles may deform the peripheral region, driving at least a portion of the fluid in the second cavity region to the cavity region defined by the anterior and posterior regions 202, 204, thereby changing the shape of the optical element 210.
[0037] In aspects where the IOL device 200 does not include a peripheral region, the anterior region 202 of the IOL device 200 may have a disk shape of sufficient diameter to engage the zonule fibers of an eye. As would be appreciated by skilled artisans upon reading the present disclosure, the diameter of the anterior region 202 (along with the dimensions associated with any other component of the IOL device 200) may be tailored for each patient according to the particular size requirements of their eye.
Bulk Polymeric Mater ial(s) of IOL Devices
[0038] As discussed above, the anterior region, posterior region, and the peripheral region (if present) of an intraocular lens (IOL) device, may each independently include a bulk polymer material. In some embodiments, this bulk polymer material may include, but is not limited to, silicone (e.g., alky siloxanes, phenyl siloxanes, fluorinated siloxanes, combinations/copolymers thereof, etc.), acrylic (e.g., alkyl acrylates, fluoracrylates, phenyl acrylate, combinations/copolymers thereof, etc.), plastic, polymeric hydrogels, and/or other hydrophilic polymer materials suitable for use in an IOL device as would be appreciated by skilled artisans upon reading the present disclosure.
[0039] In one illustrative embodiment, a bulk polymer material of the IOL device (e.g. of the anterior region, the posterior region, and/or the peripheral region) may include a fluorosilicone polymer. In some aspects, the fluorosilicone polymer may be a crosslinked copolymer of dialkyl, diphenyl or phenylalkyl siloxane and a fluorinated dialkyl siloxane. The fluorosilicone polymer may be a crosslinked copolymer of dialkyl, diphenyl or phenylalkyl
siloxane and trifluoroalkyl(alkyl)siloxane, but may be a terpolymer or higher order polymer of diphenyl and/or phenylalkyl siloxane, dialkyl siloxane and trifluoroalkyl(alkyl)siloxane. In certain aspects, the fluorosilicone polymer may be crosslinked copolymer of dialkyl siloxane, such as dimethyl siloxane, and trifluoroalkyl(alkyl)siloxane, such as 3,3,3-trifluoropropylmethyl siloxane. The ratio of dialkyl siloxane and trifluoroalkyl(alkyl)siloxane may be adjusted to tune the physical properties of the fluorosilicone polymer. For example, increasing the trifluoroalkyl(alkyl)siloxane may increase the hydrophobicity of the resulting fluorosilicone polymer. In various aspects, the fluorosilicone polymer may comprises at least about 25 mole% trifluoroalkyl(alkyl)siloxane, or about 25 mole% trifluoroalkyl(alkyl)siloxane, or about 30 mole% trifluoroalkyl(alkyl)siloxane, or about 35 mole% trifluoroalkyl(alkyl)siloxane, or about 40 mole% trifluoroalkyl(alkyl)siloxane, or about 50 mole% trifluoroalkyl(alkyl)siloxane or from about 25 mole% to about 50 mole%, or from about 25 mole% to about 40 mole% trifluoroalkyl(alkyl)siloxane.
[0040] In a specific embodiment, the aforementioned fluorosilicone polymer may be represented by formula (I):
where n and m are each independently 0 to about 500; t may be about 100 to about 1000; each R1 may be independently alkyl or aryl; R2 may be haloalkyl; R3 may be alkyl or haloalkyl; R4 and R5 are independently alkyl, haloalkyl or aryl; and each X may be a crosslinker that links the polymer of formula (I) with a second polymer of formula (I).
[0041] In various aspects, n may be about 50, or about 100, or about 125, or about 150, or about 200, or about 250, or about 300, or about 350, or about 400, or about 450, or about 500. In more aspects, m may be about 50, or about 100, or about 125, or about 150, or about 200, or about 250, or about 300, or about 350, or about 400, or about 450, or about 500. In yet more aspects, n may be about 100, and m may be about 150. In further aspects, t may be about 100, or about 125, or about 150, or about 200, or about 250, or about 300, or about 350, or about 400, or
about 450, or about 500, or about 550, or about 600, or about 650, or about 700, or about 750, or about 800, or about 850, or about 900, or about 950, or about 1000.
[0042] In additional aspects, each R1 may be alkyl. Suitable alkyl groups include, but are not limited to, Ci-C6 alkyl groups such as methyl, ethyl, n-propyl, i-propyl, n-butyl, t-butyl, n- pentyl, n-hexyl, and the like. In some aspects, R3, R4 and R5 are each alkyl, such as defined for R1. In preferred aspects, R1, R3, R4 and R5 are each methyl. In more preferred aspects, R2 may be a haloalkyl group comprising from 1 to 3 halo (provided at least one may be fluoro) substituents. Exemplary haloalkyl groups include, but are not limited to, fluoromethyl, 2- fluorethyl, 2,2-difluoroethyl, and 3,3,3-trifluoropropyl. In one embodiment, R2 may be 3,3,3- trifluoropropyl.
[0043] The crosslinker, X, may be a methylhydrosiloxane-dimethylsiloxane copolymer with a methyl-hydrogen content of from about 30 to about 70 mole%, in one aspect. In additional aspects, the crosslinker may have a chain length ranging from about 5 to about 30 repeating Si units (i.e., degree of polymerization).
[0044] In still further aspects, a bulk polymeric material of the IOL device may have a degree of polymerization ranging from about 200 to about 500, or from about 300 to about 500, or about 400, or about 450.
[0045] In certain embodiments, a bulk polymer material of the IOL device may include a fluorosilicone polymer and up to about 30 wt.% (or about 27 wt.%, or about 25 wt.%, or about 23 wt.%), or about 20 wt.%>, or from about 20 to about 30 wt.%>) of a silica component. This silica component may have a surface area of at least about 280 m2/g, or at least about 300 m2/g, or at least about 310 m2/g, or at least about 320 m2/g, or at least about 330 m2/g, or at least about 340 m2/g, or at least about 350 m2/g, in some aspects. The silica component may also have an average particle size of less than about 11 nanometers, in more aspects. Fumed silica having an average particle size of about 7 nanometers in diameter may be particularly suitable because the small particle size does not interfere with the wavelength of visible light and contributes to an improved optical resolution in the cured composition. Commercial fumed silica with particle sizes as low as 7 nm are commercially available (e.g., from CABOT and Sigma).
[0046] The silica component may be fumed or "activated" silica, which has been treated with a silazane. The amount of silica component should be such that the polymeric material may be sufficiently reinforced, yet remains optically clear. Suitable silazanes and methods for carrying out the fumed silica treatment include the in situ reaction of small particle size fumed silica and are well known in the art. In such reactions, the silazane (e.g., hexamethyldisilazane) readily reacts with the hydroxyl functionalities on fumed silica, forming a trimethylsiloxane coating on the silica surface.
[0047] The bulk polymer material of the anterior region, posterior region, and/or the peripheral region (if present) of the IOL devices disclosed herein is not limited to a fluorosilicone polymer, such as a fluorosilicone polymer of Formula I. Rather, the bulk polymer material may include other silicone materials, acrylic materials, plastic materials, and/or other biocompatible and flexible polymer materials suitable for use in an IOL device as would be appreciated by skilled artisans upon reading the present disclosure.
[0048] In further embodiments, a bulk polymer material of the IOL device may have a
Young's modulus from about 10 psi to about 150 psi, or from about 50 psi to about 100 psi, or about 70 psi. Other physical characteristics of the polymer material can be modulated as well. For instance, the bulk polymer material described herein may have a tensile strength of from about 500 psi to about 1200 psi, or from about 700 psi to about 1000 psi, or about 900 psi, in particular aspects. In more aspects, the bulk polymer material described herein may have a percent elongation of from about 400% to about 1000%, or about 600%.
[0049] In one embodiment, the IOL comprises one or a combination of the bulk polymeric material(s) described above in which the silicone oil described herein may be fully encapsulated by the bulk polymeric material(s). In another embodiment, the IOL comprises one or a combination of the bulk polymeric material(s) described above in which the silicone oil described herein may be only partially encapsulated by the bulk polymeric material(s) with the remainder being another material that may be impermeable to the silicone oil.
Lens Oil
[0050] One or more of the regions of an IOL device, particularly the bulk polymer material(s) thereof, may be in contact with a fluid, e.g., a lens oil. However, the use of
conventional lens oils, such as conventional silicone oils, can result in undesirable swelling of the bulk polymer material(s) associated with IOL devices.
[0051] Embodiments disclosed herein are therefore directed to a novel lens oil suitable for use in intraocular lens (IOL) devices. Specifically, the novel lens oil disclosed herein provides for a number of advantages owing to its narrow molecular weight distribution, and the absence/exclusion of low molecular weight components, including the reduction and/or elimination of undesirable swelling of bulk polymeric material associated with IOL devices. In preferred embodiments, the novel lens oil disclosed herein may be a silicone oil.
[0052] In one embodiment, the presently disclosed silicone oil may have a mean molecular weight average sufficient to avoid any, or substantially any, swelling of bulk polymeric material associated with the components of IOL devices. For instance, the silicone oil may have a mean molecular weight average of about 20,000 Daltons or greater, according to one aspect. In more aspects, the silicone oil may have a mean molecular weight in a range from about 20,000 Daltons to about 400,000 Daltons.
[0053] In particular aspects, the silicone oil may have a mean molecular weight of at least about 20,000 Daltons, at least about 25,000 Daltons, at least about 30,000 Daltons, at least about 35,000 Daltons, at least about 40,000 Daltons, at least about 45,000 Daltons, at least about 50,000 Daltons, at least about 55,000 Daltons, at least about 60,000 Daltons, at least about 65,000 Daltons, at least about 70,000 Daltons, at least about 75,000 Daltons, at least about 80,000 Daltons, at least about 85,000 Daltons, at least about 90,000 Daltons, at least about 95,000 Daltons, at least about 100,000 Daltons, at least about 105,000 Daltons, at least about 110,000 Daltons, at least about 115,000 Daltons, at least about 120,000 Daltons, at least about 125,000 Daltons, at least about 130,000 Daltons, at least about 135,000 Daltons, at least about 140,000 Daltons, at least about 145,000 Daltons, at least about 150,000 Daltons, at least about 155,000 Daltons, at least about 160,000 Daltons, at least about 165,000 Daltons, at least about 170,000 Daltons, at least about 175,000 Daltons, at least about 180,000 Daltons, at least about 185,000 Daltons, at least about 190,000 Daltons, at least about 195,000 Daltons, at least about 200,000 Daltons, at least about 205,000 Daltons, at least about 210,000 Daltons, at least about 215,000 Daltons, at least about 220,000 Daltons, at least about 225,000 Daltons, at least about
230,000 Daltons, at least about 235,000 Daltons, at least about 240,000 Daltons, at least about
245,000 Daltons, at least about 250,000 Daltons, at least about 255,000 Daltons, at least about
260,000 Daltons, at least about 265,000 Daltons, at least about 270,000 Daltons, at least about
275,000 Daltons, at least about 280,000 Daltons, at least about 285,000 Daltons, at least about
290,000 Daltons, at least about 295,000 Daltons, at least about 300,000 Daltons, at least about
305,000 Daltons, at least about 310,000 Daltons, at least about 315,000 Daltons, at least about
320,000 Daltons, at least about 325,000 Daltons, at least about 330,000 Daltons, at least about
335,000 Daltons, at least about 340,000 Daltons, at least about 345,000 Daltons, at least about
350,000 Daltons, at least about 355,000 Daltons, at least about 360,000 Daltons, at least about
365,000 Daltons, at least about 370,000 Daltons, at least about 375,000 Daltons, at least about
380,000 Daltons, at least about 385,000 Daltons, at least about 390,000 Daltons, at least about
395,000 Daltons, or at least about 400,000 Daltons. In another aspect, the silicone oil may have a mean molecular weight within a range that includes any two of the foregoing values.
[0054] Additionally, the presently disclosed silicone oil may have a minimal concentration of low molecular weight components to prevent any, or substantially any, swelling of bulk polymeric material associated with IOL devices. In particular aspects, 0% to about 4% of the total silicone oil by weight may be comprised of components having a molecular weight less than about 15,000 Daltons. Stated another way, no more than about 4% of the total silicone oil by weight may be comprised of components having a molecular weight less than about 15,000 Daltons. In preferred aspects, the silicone oil may comprise no more than about 3 wt.%, no more than about 2 wt.%, no more than about 1 wt.%, no more than about 0.05 wt.%, or no more than about 0.005 wt.% of components having a molecular weight less than about 15,000 Daltons.
[0055] In more preferred aspects, the total silicone oil by weight may be comprised of components having a molecular weight greater than about 5,000 Daltons. In one non-limiting embodiment, the silicone oil does not include any component having a molecular weight of about 5,000 Daltons or less. The inclusion of components having a molecular weight of about 1,000 Daltons, or about 2,000 Daltons, or about 3,000 Daltons, or about 4,000 Daltons, or even about 5,000 Daltons in the silicone oil may, in certain instances, lead to unfavorable swelling of the bulk polymeric material(s) associated with the IOL devices described herein. In another
embodiment, no more than about 3% to about 4% of the total silicone oil by weight may be comprised of components having a molecular weight less than about 15,000 Daltons. In yet another embodiment, no components in the silicone oil have a molecular weight less than 5,000 Daltons.
[0056] The presently disclosed silicone oil may further have a narrow molecular weight distribution, and thus a low polydispersity index (PDI), in various embodiments. For example, the silicone oil may have a PDI of about 1.5 or greater, in one exemplary aspect. In another exemplary aspect, the silicone oil may have a PDI of about 2.4.
[0057] The presently disclosed silicone oil may have a viscosity in a range from about
4,000 mm2/s at 25 °C to about 100,000 mm2/s at 25 °C in certain embodiments. In preferred aspects, the viscosity of the presently disclosed silicone oil may be about 5,000 mm2/s at 25 °C or greater.
[0058] In some aspects, the presently disclosed silicone oil may have a viscosity in a range from about 4,000 mm2/s at 25 °C to about 15,000 mm2/s at 25 °C. In exemplary aspects, the silicone oil may have a viscosity of about 4,000 mm2/s at 25 °C, about 4,500 mm2/s at 25 °C, about 5,000 mm2/s at 25 °C, about 5,500 mm2/s at 25 °C, about 6,000 mm2/s at 25 °C, about 6,500 mm2/s at 25 °C, about 7,000 mm2/s at 25 °C, about 7,500 mm2/s at 25 °C, about 8,000 mm2/s at 25 °C, about 8,500 mm2/s at 25 °C, about 9,000 mm2/s at 25 °C, about 9,500 mm2/s at 25 °C, about 10,000 mm2/s at 25 °C, about 10,500 mm2/s at 25 °C, about 11,000 mm2/s at 25 °C, about 11,500 mm2/s at 25 °C, about 12,000 mm2/s at 25 °C, about 12,500 mm2/s at 25 °C, about 13,000 mm2/s at 25 °C, about 13,500 mm2/s at 25 °C, about 14,000 mm2/s at 25 °C, about 14,500 mm2/s at 25 °C, or about 15,000 mm2/s at 25 °C. The silicone oil may have a viscosity including and between any two of the foregoing values.
[0059] In additional aspects, the presently disclosed silicone oil may have a viscosity greater than about 15,000 mm2/s at 25 °C. In exemplary aspects, the silicone oil may have a viscosity of about 20,000 mm2/s at 25 °C, about 25,000 mm2/s at 25 °C, about 30,000 mm2/s at 25 °C, about 35,000 mm2/s at 25 °C, about 40,000 mm2/s at 25 °C, about 45,000 mm2/s at 25 °C, about 50,000 mm2/s at 25 °C, about 55,000 mm2/s at 25 °C, about 60,000 mm2/s at 25 °C, about
65,000 mm2/s at 25 °C, about 70,000 mm2/s at 25 °C, about 75,000 mm2/s at 25 °C, about 80,000 mm2/s at 25 °C, about 85,000 mm2/s at 25 °C, about 90,000 mm2/s at 25 °C, about 95,000 mm2/s at 25 °C, or about 100,000 mm2/s at 25 °C. The silicone oil may have a viscosity including and between any two of the foregoing values.
[0060] In additional embodiments, the presently disclosed silicone oil may be substantially index-matched to the bulk material(s) of IOL devices. As used herein, an index- matched material refers to a material whose index of refraction may be about equal to, or closely approximates, the index of refraction of another material. In some aspects, the presently disclosed silicone oil may have an index of refraction in a range from about 1.40 to about 1.60. In particular aspects, the presently disclosed silicone oil may have an index of refraction of about 1.49.
[0061] In more embodiments, the presently disclosed silicone oil may comprise an aryl siloxane and an alkyl siloxane. Suitable aryl groups for the aryl siloxane may include, but are not limited to, phenyl, naphthyl, toluyl, xylyl, and the like. Suitable alky groups may include, but are not limited to, methyl, ethyl, n-propyl, i-propyl, n-butyl, t-butyl, n-pentyl, n-hyexyl, and the like. The aryl groups of the aryl siloxane may help prevent diffusion of the silicone oil through the bulk polymer material(s) of IOL device due to steric effects. As such, the silicone oil may comprise a greater percentage of aryl siloxane as compared to alky siloxane in some aspects.
[0062] In one exemplary embodiment, the silicone oil may comprise a copolymer represented by formula (II):
where each of n and m may be independently an integer ranging from 0 to about 500; each R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 may be independently hydrogen, alkyl, alkenyl, or aryl,
optionally substituted analogs thereof, or other suitable saturated or unsaturated functional group as would be apparent to skilled artisans upon reading the present disclosure.
[0063] In various aspects, n may be about 50, or about 100, or about 125, or about 150, or about 200, or about 250, or about 300, or about 350, or about 400, or about 450, or about 500. In more aspects, m may be about 50, or about 100, or about 125, or about 150, or about 200, or about 250, or about 300, or about 350, or about 400, or about 450, or about 500. In some aspects, n and/or m may be integers greater than about 500. The n and m may correspond to integers designated a repeating siloxane unit, where n and m may be independently selected to achieve a desired molecular weight of the resulting silicone copolymer, and/or selected to achieve a desired ratio of the particular siloxane polymer units to which n and m correspond.
[0064] As used herein in various aspects, the term "alky" may refer to a straight or branched hydrocarbon chain radical consisting solely of carbon and hydrogen atoms, which may be saturated or unsaturated (i.e., contains one or more double and/or triple bonds), having from one to twenty carbon atoms (C1-C20 alkyl), and which may be attached to the rest of the molecule by a single bond. Suitable alkyl groups may include, but are not limited to methyl, ethyl, n- propyl, i-propyl, n-butyl, t-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, etc.
[0065] As also used herein in various aspects, the term "alkenyl" may refer to a linear or branched hydrocarbon radical having from one to twenty carbon atoms, and containing at least one double bond. Suitable alkenyl groups may include, but are not limited to, vinyl, 2-propenyl, crotyl, 2-isopentenyl, etc.
[0066] As further used herein in various aspects, the term "aryl" may refer to a hydrocarbon ring system radical comprising hydrogen, 6 to 18 carbon atoms and at least one aromatic ring. For purposes of this invention, the aryl radical may be a monocyclic, bicyclic, tricyclic or tetracyclic ring system, which may include fused or bridged ring systems. Aryl radicals include, but are not limited to, aryl radicals derived from aceanthrylene, acenaphthylene, acephenanthrylene, anthracene, azulene, benzene, chrysene, fluoranthene, fluorene, as-indacene, s-indacene, indane, indene, naphthalene, phenalene, phenanthrene, pleiadene, pyrene, and triphenylene.
[0067] As additionally used herein in various aspects, the term "optionally substituted" may refer to any of the aforementioned functional groups (e.g., alkyl, alkylene, aryl, etc.) where at least one hydrogen atom may be replaced by a bond to a non-hydrogen atoms such as, but not limited to: a halogen atom (e.g., F, CI, Br, and I); an oxygen atom in groups such as hydroxyl groups, alkoxy groups, and ester groups; a sulfur atom in groups such as thiol groups, thioalkyl groups, sulfone groups, sulfonyl groups, and sulfoxide groups; a nitrogen atom in groups such as amines, amides, alkylamines, dialkylamines, arylamines, alkylarylamines, diarylamines, N- oxides, imides, and enamines; a silicon atom in groups such as trialkylsilyl groups, dialkylarylsilyl groups, alkyldiarylsilyl groups, and triarylsilyl groups; and other heteroatoms in various other groups. "Optionally substituted" may also mean any of the above groups in which one or more hydrogen atoms are replaced by a higher-order bond (e.g., a double- or triple-bond) to a heteroatom such as oxygen in oxo, carbonyl, carboxyl, and ester groups; and nitrogen in groups such as imines, oximes, hydrazones, and nitriles.
[0068] In some aspects, R1 and/or R10 may be hydrogen. In more aspects, each of R1 and
R10 may be independently alkyl or an optionally substituted alkyl. In yet more aspects, each of R1 and R10 may be independently aryl or an optionally substituted analog thereof.
[0069] In still more aspects, R1 and/or R10 may be independently alkenyl or an optionally substituted alkenyl. In some aspects, R1 and/or R10 may be a reactive functional group (e.g., an unsaturated alkenyl) configured to couple (e.g., via a crosslinking reaction) to a reactive group of another polymer, which may also comprise a copolymer of formula (II). Aspects where R1 and/or R10 may be a reactive functional group may be especially advantageous for use in an IOL device. For instance, lens oil, e.g., comprising copolymer chains of formula (II) and/or other suitable polymer chains, may be injected into the cavity region of an IOL device via an opening (e.g., valve, port, puncture wound, etc.) in the bulk polymer material thereof, and the opening subsequently sealed via a self-sealing process, a plug, or other suitable means. The inclusion of polymer chains having at least one reactive group (per chain) allows at least some of the polymer chains to be crosslinked with one another, and thereby form a gel, within the IOL device. Moreover, these polymer chains having at least one reactive group (per chain) can participate in the formation of a polymerized sealing plug, and do not interfere with the sealing, by virtue of any residue of the silicone oil becoming crosslinked into the polymer cure of the plug. In some
aspects, the silicone oil within the IOL device may be a lightly crosslinked gel, whose unreacted polymer chains do not diffuse through the bulk polymer material of the IOL device.
[0070] In one particular aspect, R1 and/or R10 may be vinyl. The addition of vinyl terminated reactive silicone copolymers of formula (II) in the cavity region of the IOL device may be beneficial as said copolymers are stable (i.e., do not degrade when exposed to the environment of a human eye), can form a crosslinked gel within the IOL device, and do not interfere, and may participate, with the aforementioned sealing process of the IOL device. As discussed in greater detail below, vinyl terminated reactive silicone polymers of formula (II) may be cured via combination with a suitable crosslinking agent and a curing agent to form the desired, resulting silicone oil, i.e., a silicone oil that does not pass into the free volume of the bulk polymer material of the IOL device and cause swelling thereof.
[0071] In one aspect, R1 and/or R10 may include a reactive terminal end group other than vinyl in certain aspects. Further, in other aspects, R1 and/or R10 may be a non-reactive group (e.g., a saturated functional group) that does not participate in polymerization.
[0072] In some aspects, R1 and/or R10 may include a methylhydrosiloxane- dimethylsiloxane copolymer with a methyl-hydrogen content ranging from about 30 to about 70 mole%. In particular aspects, the methylhydrosiloxane-dimethylsiloxane copolymer may have chain length of about 5 to about 30 repeating Si units (i.e., degree of polymerization).
[0073] In additional aspects, each of R2, R3, R8, and R9 may be independently alkyl, aryl, or optionally substituted analogs thereof. In more aspects, each of R2, R3, R8, and R9 may be independently alkyl or an optionally substituted alkyl. In one such aspect, each of R2, R3, R8, and R9 may be methyl.
[0074] In some aspects, each of R4 and R5 may be independently alky, aryl, or optionally substituted analogs thereof. In various aspects, each of R4 and R5 may be independently alkyl or an optionally substituted alkyl. In one such aspect, R4 and/or R5 may be methyl.
[0075] In more aspects, each of R6 and R7 may be independently alky, aryl, or substituted analogs thereof. In various aspects, each of R6 and R7 may be independently aryl or an
optionally substituted aryl. In one aspect, R6 and/or R7 may be phenyl. In more aspects, R6 may be alkyl and R7 may be aryl. In one such aspect, R6 may be methyl and R7 may be phenyl.
[0076] In one exemplary aspect, each of R1 and R10 may be vinyl; each of R2, R3, R4, R5,
R8, and R9 may be methyl; and each of R6 and R7 may be phenyl. In another exemplary aspect, R1 and R10 may be vinyl; each of R2, R3, R4, R5, R6, R8, and R9 may be methyl; and R7 may be phenyl.
[0077] In preferred embodiments, the presently disclosed silicone oil may comprise dimethylsiloxane and diphenylsiloxane. Moreover, the silicone oil may comprise dimethylsiloxane in an amount ranging from about 20 mole% to about 25 mole% (preferably about 22 mole% to about 25 mole%), and diphenylsiloxane in an amount ranging from about 80 mole% to about 75 mole% (preferably about 78 mole% to about 75 mole%) in various aspects.
[0078] In more embodiments, the presently disclosed silicone oil may comprise dimethylsiloxane (about 0 mole% to about 100 mole%) and methylphenylsiloxane (about 0 mole% to about 100 mole%).
[0079] The presently disclosed silicone oil may be manufactured using known synthesis and polymer chemistry techniques. For instance, methods of making the silicone oil may include anionic addition polymerization, living polymerization, living anionic polymerization, etc.
[0080] In one non-limiting embodiment, a method of making the presently disclosed silicone oil may comprise: (a) providing vinyl terminated/end-blocked diphenylsiloxane- dimethyl siloxane copolymers to obtain a polymer composition; (b) adding a crosslinking agent and a curing agent to the polymer composition; and (c) curing the polymer composition to obtain a diphenylsiloxane-dimethylsiloxane silicone oil. The vinyl terminated diphenylsiloxane- dimethylsiloxane may be synthesized using known methods from commercially available starting materials or purchased from commercial sources. Suitable vinyl endblockers include, but are not limited to, a vinyl-endblocked dimethyl siloxane oligomer. The resulting oil may also be lightly crosslinked in some aspects, having less than about 5 parts per hundred (pph)
crosslinker, or less than about 4 pph, or less than about 2 pph, or less than about 1 pph crosslinker, etc.
[0081] In some aspects, the curing step may include addition of a platinum catalyst. The platinum group metal catalyst may be any of the compatible platinum group metal-containing catalysts known to catalyze the addition of silicone-hydrogen atoms to silicon-bonded vinyl radicals. Platinum group metal-containing catalysts may be any of the known forms which are compatible, such as platinic chloride, salts of platinum, chloroplatinic acid and various complexes, for example, silicone complexes with platinum metal-containing groups. The platinum group metal-containing catalyst may be used in any catalytic quantity, such as in an amount sufficient to provide at least about 0.1 ppm weight of platinum group metal (as elemental metal) based on the total weight of the composition. In certain aspects, at least about 10 ppm, or at least about 20 ppm, or at least 30 ppm, or at least about 40 ppm by weight of platinum catalyst may be used.
[0082] The presently disclosed silicone oil may be purified using known extraction/fractionation techniques so as to remove low molecular weight components, in preferred embodiments. For example, in one aspect, the silicone oil may be purified via supercritical fluid extraction using supercritical C02, propane, ethane, ethylene, combinations thereof, and/or other suitable eluting solvent as would be appreciated by skilled artisans upon reading the present disclosure.
[0083] In another aspect, size exclusion chromatography (SEC), also referred to as gel permeation chromatography (GPC), may be used to purify the silicone oil. SEC/GPC is a technique that utilizes a column packed with porous crosslinked gels to separate polymer molecules according to their size.
EXAMPLES
[0084] An exemplary silicone oil according to the present disclosure was provided, and analyzed as follows.
[0085] A silicone oil comprised of dimethylsiloxane and diphenysiloxane was fractionated by supercritical fluid extraction. FIG. 3 provides GPC chromatograms of detector
response (au) versus retention time (minutes) for various fractions of diphenyl-dimethyl siloxane obtained via supercritical fluid extraction. A UV/VIS detector (256 nm) was used to detect the fractions. Based on a comparison to a GPC calibration curve, fraction 5 indicated in FIG. 3 corresponded to the desired narrow molecular weight distribution, and minimal amount of low molecular weight components disclosed herein (e.g., no more than about 3 wt.% to about 4 wt.% of any component having a molecular weight less than about 15,000 Daltons, and more preferably no components having a molecular weight less than about 5,000 Daltons).
[0086] Fraction 5 was further subject to a swell study to determine the degree to which a bulk polymer material of known weight and dimensions swelled when in contact therewith. Such a swell study included preparing a lens (e.g., having a 7 mm shell) comprised of a bulk polymer material, contacting the silicone oil (i.e., fraction 5) to the bulk polymer material, measuring the dimensions and weight of the bulk polymer material over time, and comparing the measurements to the original dimensions and weight of the bulk polymer material. Such comparison provides an indication of how much the polymer material "swelled" (i.e., how much its dimensions and weight increased). It was surprisingly and unexpectedly found that a silicone oil comprised of fraction 5, having less than about 4 wt.% of any component with a molecular weight less than about 15,000 Daltons, and more preferably no components with a molecular weight less than about 5,000 Daltons, resulted in no swelling of the bulk polymer material when in contact therewith. Specifically, the dimensions of the polymer based lens remained at 7 mm after contact with fraction 5.
[0087] FIG. 4 provides further verification that fraction 5 resulted in no swelling of the polymer lens material to which it was exposed. As indicated above, fraction 5 excludes substantially all low molecular weight components that typically diffuse into the bulk polymer material of an IOL device and which lead to undesirable swelling of the bulk polymer material, as well as undesirable changes in the optical properties of the IOL device. For instance, as shown in FIG. 4, the measurement of the average power (in diopters) of the polymer based lens did not change upon overnight exposure to/contact with fraction 5.
[0088] The invention described and claimed herein is not to be limited in scope by the specific preferred embodiments disclosed herein, as these embodiments are intended as
illustrations of several aspects of the invention. Indeed, various modifications of the invention in addition to those shown and described herein will become apparent to those skilled in the art from the foregoing description. Such modifications are also intended to fall within the scope of the appended claims.
Claims
1. A silicone oil having a mean molecular weight of about 20,000 Daltons or greater, wherein no more than about 3% to about 4% of the total silicone oil by weight is comprised of components having a molecular weight less than about 15,000 Daltons.
2. The silicon oil of claim 1, wherein the silicone oil has a mean molecular weight average in a range from about 20,000 Daltons to about 400,000 Daltons.
3. The silicone oil of claim 1, wherein the total silicone oil by weight is comprised of components having a molecular weight greater than about 5,000 Daltons.
4. The silicone oil of claim 1, wherein the silicone oil has a viscosity of about 4,000 mm2/s at 25 °C or greater.
5. The silicone oil of claim 1, wherein the silicone oil has a refractive index of about 1.49.
6. The silicone oil of claim 1, wherein the silicon oil has a polydispersity index of about 1.5 or greater.
7. The silicone oil of claim 1, wherein the silicone oil comprises diphenylsiloxane and dimethylsiloxane.
8. The silicone oil of claim 7, wherein the silicone oil comprises about 20 mole% to about 25 mole% diphenylsiloxane and about 80 mole% to about 75 mole% of dimethylsiloxane.
9. An intraocular lens (IOL) device, comprising: an anterior region; a posterior region; a cavity region defined between the anterior and posterior regions; and a fluid disposed in the cavity region, the fluid comprising a silicone oil having a mean molecular weight average greater than about 20,000 Daltons, wherein no more than about
3% to about 4% of the total silicone oil by weight is comprised of components having a molecular weight less than about 15,000 Daltons.
10. The IOL device of claim 9, wherein silicone oil has no component having a molecular weight less than about 5,000 Daltons.
11. The IOL device of claim 9, wherein the silicone oil has a viscosity of about 4,000 mm2/s at 25 °C or greater.
12. The IOL device of claim 9, wherein the silicone oil has a refractive index of about 1.49.
13. The IOL device of claim 9, wherein the silicon oil has a polydispersity index of about 1.5 or greater.
14. The IOL device of claim 9, wherein the silicone oil comprises diphenyl siloxane and dimethylsiloxane.
15. The IOL device of claim 14, wherein the silicone oil comprises about 20 mole% to about 25 mole% of diphenylsiloxane and about 80 mole% to about 75 mole% of dimethylsiloxane.
16. The IOL device of claim 9, wherein the anterior portion comprises a refractive optical element, and wherein at least a portion of the posterior portion comprises an elastic material configured to actuate in response to a force applied thereto, causing the fluid to exert a deforming or displacing force on the refractive optical element.
17. The IOL device of claim 9, wherein at least one of the anterior region and the posterior region comprises a bulk polymeric material.
18. An intraocular (IOL) device configured for implantation in a lens capsule of a patient's eye, the IOL device comprising: a silicone oil having a mean molecular weight average greater than about 20,000 Daltons, wherein the silicone oil is purified such that no component thereof has a molecular weight less than about 5,000 Daltons, and a bulk polymeric material, wherein at least a portion of the bulk material is in physical contact with the silicone oil.
19. The IOL device of claim 18, wherein the silicone oil is entirely encapsulated by the bulk polymeric material.
20. The IOL device of claim 18, wherein the bulk polymeric material is a fluorosilicone polymer may be represented by formula (I):
where n and m are each independently 0 to about 500; t is about 100 to about 1000; each R1 is independently alkyl or aryl; R2 is haloalkyl; R3 is alkyl or haloalkyl; R4 and R5 are independently alkyl, haloalkyl or aryl; and each X is a crosslinker that links the polymer of formula (I) with a second polymer of formula (I).
21. The IOL device of claim 20, wherein the crosslinker, X, is a methylhydrosiloxane- dimethylsiloxane copolymer with a methyl-hydrogen content of from about 30 to about 70 mole%.
22. The IOL device of claim 18, wherein the silicone oil is purified using supercritical fluid extraction.
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JP2019514198A JP2019519664A (en) | 2016-05-27 | 2017-05-26 | Narrow molecular weight distribution lens oil for intraocular lens devices |
CN201780044586.3A CN109789012A (en) | 2016-05-27 | 2017-05-26 | The crystalline lens oil with Narrow Molecular Weight Distribution for intraocular lens body device |
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Also Published As
Publication number | Publication date |
---|---|
US20200157124A1 (en) | 2020-05-21 |
CN109789012A (en) | 2019-05-21 |
EP3463188B1 (en) | 2023-04-26 |
US10526353B2 (en) | 2020-01-07 |
JP2019519664A (en) | 2019-07-11 |
EP3463188A1 (en) | 2019-04-10 |
US20170342096A1 (en) | 2017-11-30 |
EP3463188A4 (en) | 2020-03-11 |
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