WO2017193180A8 - Compostos derivados de isatina, uso dos compostos no tratamento de aids e método de tratamento usando ditos compostos - Google Patents

Compostos derivados de isatina, uso dos compostos no tratamento de aids e método de tratamento usando ditos compostos Download PDF

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Publication number
WO2017193180A8
WO2017193180A8 PCT/BR2016/000050 BR2016000050W WO2017193180A8 WO 2017193180 A8 WO2017193180 A8 WO 2017193180A8 BR 2016000050 W BR2016000050 W BR 2016000050W WO 2017193180 A8 WO2017193180 A8 WO 2017193180A8
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WO
WIPO (PCT)
Prior art keywords
compounds
treatment
formulae
iii
isatin
Prior art date
Application number
PCT/BR2016/000050
Other languages
English (en)
French (fr)
Other versions
WO2017193180A1 (pt
Inventor
Nubia Boechat
Mônica Macedo BASTOS
Thiago Moreno LOPES E SOUZA
Débora Inácio LEITE
Alice Maria Rolim BERNARDINO
Original Assignee
Fundação Oswaldo Cruz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundação Oswaldo Cruz filed Critical Fundação Oswaldo Cruz
Priority to BR112018072494-7A priority Critical patent/BR112018072494B1/pt
Priority to EP16901168.1A priority patent/EP3456718B1/en
Priority to US16/099,901 priority patent/US10538515B2/en
Priority to PCT/BR2016/000050 priority patent/WO2017193180A1/pt
Publication of WO2017193180A1 publication Critical patent/WO2017193180A1/pt
Publication of WO2017193180A8 publication Critical patent/WO2017193180A8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A presente invenção se refere a compostos inibidores do HIV consistindo de derivados de isatina de fórmulas I, II e III, conforme representados a seguir (fórmulas I, II e III) onde nas fórmulas I, II e III, R1 é selecionado dentre H, CH3 ou Cl R2 é selecionado dentre um dos seguintes radicais: zidovudina, amprenavir ou uma cadeia fosfonato acíclica, representados a seguir. A presente invenção também consiste do uso e do método de tratamento usando os compostos de fórmulas I, II e III. Os compostos da presente invenção também são usados no tratamento de uma infecção causada pelo HBV ou na coinfecção causada pelo HIV e HBV.
PCT/BR2016/000050 2016-05-10 2016-05-10 Compostos derivados de isatina, uso dos compostos no tratamento de aids e método de tratamento usando ditos compostos WO2017193180A1 (pt)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BR112018072494-7A BR112018072494B1 (pt) 2016-05-10 2016-05-10 Composto derivado de isatina, e, uso do composto
EP16901168.1A EP3456718B1 (en) 2016-05-10 2016-05-10 Isatin-derived compounds, use of the compounds for the treatment of aids and hbv infections
US16/099,901 US10538515B2 (en) 2016-05-10 2016-05-10 Isatin-derived compounds, use of the compounds for the treatment of AIDS and method of treatment using these compounds
PCT/BR2016/000050 WO2017193180A1 (pt) 2016-05-10 2016-05-10 Compostos derivados de isatina, uso dos compostos no tratamento de aids e método de tratamento usando ditos compostos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/BR2016/000050 WO2017193180A1 (pt) 2016-05-10 2016-05-10 Compostos derivados de isatina, uso dos compostos no tratamento de aids e método de tratamento usando ditos compostos

Publications (2)

Publication Number Publication Date
WO2017193180A1 WO2017193180A1 (pt) 2017-11-16
WO2017193180A8 true WO2017193180A8 (pt) 2018-11-22

Family

ID=60266088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2016/000050 WO2017193180A1 (pt) 2016-05-10 2016-05-10 Compostos derivados de isatina, uso dos compostos no tratamento de aids e método de tratamento usando ditos compostos

Country Status (4)

Country Link
US (1) US10538515B2 (pt)
EP (1) EP3456718B1 (pt)
BR (1) BR112018072494B1 (pt)
WO (1) WO2017193180A1 (pt)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102171208A (zh) * 2008-09-05 2011-08-31 帝国创新有限公司 用作体内显像剂的靛红衍生物

Also Published As

Publication number Publication date
EP3456718B1 (en) 2021-02-17
BR112018072494A2 (pt) 2019-03-12
US20190177305A1 (en) 2019-06-13
EP3456718A1 (en) 2019-03-20
WO2017193180A1 (pt) 2017-11-16
US10538515B2 (en) 2020-01-21
BR112018072494B1 (pt) 2022-01-11
EP3456718A4 (en) 2019-10-23

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