WO2017193082A1 - Appareils, procédés et systèmes pour administrer des médicaments au moyen de trousses de médicaments - Google Patents

Appareils, procédés et systèmes pour administrer des médicaments au moyen de trousses de médicaments Download PDF

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Publication number
WO2017193082A1
WO2017193082A1 PCT/US2017/031420 US2017031420W WO2017193082A1 WO 2017193082 A1 WO2017193082 A1 WO 2017193082A1 US 2017031420 W US2017031420 W US 2017031420W WO 2017193082 A1 WO2017193082 A1 WO 2017193082A1
Authority
WO
WIPO (PCT)
Prior art keywords
drug
dosing device
medical treatment
patient
medicine
Prior art date
Application number
PCT/US2017/031420
Other languages
English (en)
Inventor
Caleb HERNANDEZ
Original Assignee
Certa Dose, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/282,732 external-priority patent/US11617835B2/en
Application filed by Certa Dose, Inc. filed Critical Certa Dose, Inc.
Priority to MX2018013503A priority Critical patent/MX2018013503A/es
Priority to AU2017261355A priority patent/AU2017261355B2/en
Priority to EP17793509.5A priority patent/EP3452147A4/fr
Priority to CN201780037854.9A priority patent/CN109641106B/zh
Priority to KR1020187035175A priority patent/KR102638625B1/ko
Priority to JP2018557892A priority patent/JP7297446B2/ja
Priority to CA3023362A priority patent/CA3023362A1/fr
Publication of WO2017193082A1 publication Critical patent/WO2017193082A1/fr
Priority to JP2022041520A priority patent/JP2022079520A/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/1782—Devices aiding filling of syringes in situ
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1072—Measuring physical dimensions, e.g. size of the entire body or parts thereof measuring distances on the body, e.g. measuring length, height or thickness
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A61M2005/3126—Specific display means related to dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A61M2205/584—Means for facilitating use, e.g. by people with impaired vision by visual feedback having a color code
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6009—General characteristics of the apparatus with identification means for matching patient with his treatment, e.g. to improve transfusion security
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6045—General characteristics of the apparatus with identification means having complementary physical shapes for indexing or registration purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6063—Optical identification systems
    • A61M2205/6081—Colour codes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels

Definitions

  • the present disclosure relates to a medicine-dosing device, and more particularly to a pre-labeled medicine dosing device and method for administering appropriate doses of medicine in an emergency or critical care situations.
  • Drug dosages conventionally are determined based on the weight of the patient. However this method can, at times, be inappropriate and inaccurate especially in the emergency and critical care situations. Thus, at times, patient length can be used, as it allows for a quick and efficient determination of drug dosages, involves the use of a color coded measuring tape for determining the length of a patient. More specifically, the Broselow ® Pediatric Emergency Tape is a well known instrument that correlates easily obtainable patient length to drug dosages. The details of the instrument and the method of its use are disclosed in the U.S. patents 4,716,888 and 6, 132,416 to Broselow which are incorporated by reference into the present disclosure.
  • the method involves measuring and coding patient length to one of the color zones provided on the tape and using the color-coded length to determine a drug dosage to be administered to the patient.
  • the tape By segmenting the tape into plurality of color coded zones rather than the typically used inches or centimeters, with each color zone corresponding to a given length range, the length of the patient can be easily read and noted as being of a certain color rather than as a specific measurement in centimeters or inches.
  • each color-coded length zone corresponds to a certain, predetermined range of the actual lengths as measured in either metric or imperial units.
  • the grey color zone on the tape may correspond to a length range from 42.20 cm to 60.79 cm and the pink color zone on the tape may correspond to the length range from 60.80 cm to 67.79 cm.
  • a patient whose length falls within the first length range would be coded as gray and a patient whose length falls within the second length range would be coded as pink.
  • the appropriate drug dosages for the two patients would then be selected from a list of predetermined drug dosages listed on the tape.
  • Other commercially available length/weight-based tapes such as the PediaTape and the Handtevy tape, are used in a similar fashion.
  • kits capable of facilitating treatment of complex medical problems is disclosed herein.
  • the disclosed kits are each typically targeted to treatment of a specific medical problem, such treatment requiring that a specific sequence of medications be given in a correct order and dose.
  • the medical problems involved may place human live in the balance, and mistakes can be fatal. In these situations correct dosing and delivery can be life saving.
  • the medical treatment kit may provide a vial, including a drug, and a medicine dosing device.
  • the medicine dosing device may be configured to receive the drug from the vial and deliver the drug to a patient. Further, the dosing device may be marked with coded dosage zones, which can have varying widths, and which correspond to predetermined drug doses.
  • the kit may also include an instrument for associating the patient with one of the coded dosage zones.
  • the kit may include a filling needle that attaches to the medicine dosing device and which is configured to draw the drug to be administered from the vial, so as to fill the medicine dosing device with a dose of the drug that corresponds to one of the coded dosage zones.
  • the needle may be permanently attached to the syringe.
  • the medicine dosing device may be a syringe, and in some implementations, the syringe may be permanently attached to the needle.
  • the vial of the drug and the medicine dosing device may be labelled.
  • the vial and medicine dosing device are marked with the name and/or
  • the vial and the medicine dosing device may be labelled with a symbol, and the symbol may correspond to the drug and/or the concentration of the drug.
  • the instrument for associating the patient with one of the coded dosage zones may be a color coded measuring tape.
  • the patient may be measured with the color coded measuring tape in order to determine the color coded dosage zone to which the medical dosing device should be filled with the drug.
  • the medical treatment kit may further comprise an instruction sheet, which may provide steps for administering the drug.
  • the predetermined drug doses and/or the widths of the coded dosage zones marked on the medicine dosing device may correspond to the drug that is included in the vial.
  • the kit may provide a second vial of a second drug and a second medicine dosing device that is configured to receive the second drug from the second vial and deliver the second drug to the patient.
  • the second medicine dosing device may be marked with coded dosage zones of second varying widths that correspond to second predetermined drug doses.
  • the second predetermined drug doses and the second coded dosage zones may be different than the predetermined drug doses and coded dosage zones.
  • the vial and the medicine dosing device may be marked with a first symbol, and the first symbol may correspond to the drug and a concentration of the drug.
  • the second vial and the second medicine dosing device may be marked with a second symbol, and the second symbol may correspond to the second drug and a concentration of the second drug.
  • the second symbol may be different from the first symbol.
  • the second drug may be a different concentration of the first drug.
  • the kit may also include an instruction sheet.
  • the instruction sheet may specify that the first drug should be administered to the patient before the second drug is administered to the patient.
  • a method of administering a plurality of drugs to a patient may include associating the patient with one of a plurality of coded dosage zones using an instrument included within a medical treatment kit.
  • a first vial containing a first drug may be selected from the medical treatment kit, and the first drug may be drawn from the first vial so as to fill a first medicine dosing device included within the medical treatment kit with a first dose of the first drug.
  • the first dose may correspond to the one of the first plurality of coded dosage zones, wherein the first medicine dosing device is marked with the first plurality of coded dosage zones, and the first plurality of coded dosage zones are of first varying widths.
  • a second vial containing a second drug may be selected from the medical treatment kit, and the second drug may be drawn from the second vial to as to fill a second medicine dosing device that is included within the medical treatment kit with a second dose of the second drug.
  • the second dose may correspond to the one of the second plurality of coded dosage zones, wherein the second medicine dosing device is marked with the second plurality of coded dosage zones.
  • the second plurality of coded dosage zones may be of second varying widths.
  • the first drug and the second drug may be administered to the patient using the first medicine dosing device and the second medicine dosing deice.
  • a sequence of administration of the first drug and the second drug may be indicated by instructions that are associated with the medical treatment kit.
  • FIGS. 1A-1D are perspective views of a medicine-dosing device according to one embodiment of the current disclosure.
  • FIG. IE is a perspective view of another embodiment of a medicine-dosing device according to an embodiment of the current disclosure.
  • FIGS. 2A -2D are perspective views of a medicine-dosing device according to another embodiment of the current disclosure.
  • FIGS. 3A - 3D are plan views of the labels with the color-coded medication doses.
  • FIG. 4 is flow diagram showing a method of determining and printing the color-coded medication dose labels.
  • FIG. 5 is flow diagram showing a method of administering a medication using the disclosed pre-filled and marked medicine-dosing device.
  • FIG. 6 illustrates a measuring instrument used to determine a color-coded length of a patient.
  • FIG. 7A illustrates a method of administering a medication using the disclosed emergency medical treatment kit that includes the pre-marked medicine dosing device.
  • FIG. 7B illustrates the emergency medical treatment kit for administering a medication according to one embodiment of the current disclosure.
  • FIG. 7C illustrates an exemplary medical treatment kit for administering medication to treat anaphylaxis, allergy, and/or asthma.
  • FIG. 7D illustrates an exemplary medical treatment kit for administering medication corresponding to rapid sequence intubation.
  • FIGS. 7E-F illustrate exemplary embodiments of an adult syringe.
  • FIGS. 8A-8F includes data showing improvements in the drug delivery using the system and methods of the current disclosure.
  • the present application describes a device, system, and method for administering proper medication doses to patients.
  • the device and system are configured to address the five rights of medicine delivery; that is, giving the right patient the right drug in the right dose by the right route at the right time.
  • a pre-marked medicine dosing/dispensing device designed to minimize medication dosing errors, as well as to improve the overall accuracy and efficiency of administering medication, especially in the emergency and critical care situations, is provided.
  • the medicine dosing device 10 is a syringe 15 that includes an elongate barrel 30 marked with predetermined color-coded volumetric medicine doses 100 and a plunger 50.
  • the medicine-dosing device may be further pre-filled with a fluid 105 that corresponds to a medication to be administered to a patient.
  • a method for determining specific volumetric doses for a plurality of medications based on different factors is also disclosed.
  • the method involves generating labels or marking medical dosing devices with doses that are determined based on, for example, volumetric capacity of medical dosing device and/or drug concentration.
  • the medicine dosing device 10 is a syringe 15 that includes a proximal end 25 and a distal end 20 opposite the proximal end.
  • the syringe includes a vessel, such as a syringe barrel 30 at the distal end for holding therein a medicine that is to be dispensed, and a plunger 50 that extends proximally from an opening 36 located at the proximal end 35 of the syringe barrel to the proximal end 55 of the plunger at the proximal end 25.
  • the syringe barrel and plunger are both manufactured from material such as plastic, glass or any other suitable transparent medical grade material that is inert or will not disrupt the chemical balance of the fluid inside.
  • the syringe barrel 30 is elongate and substantially cylindrical and includes a distal end 31 and a proximal end 35.
  • the syringe barrel further includes and outer circumferential surface 37 and an inner circumferential surface 38.
  • a chamber 32 capable of receiving a plunger and retaining a fluid therein is defined by the inner circumferential surface 38 of the barrel between the distal and proximal ends 31 and 35.
  • a flange 33 which can serve as a finger grip to provide for an easier handing of the syringe, is integrally formed with the proximal end of the barrel and defines an opening 36 for receiving the plunger.
  • Proximate the opening 36, along the inner surface of the barrel is a ridge 34, shown in FIG. 1C, that prevents the plunger from slipping out of the barrel once it is engaged with the barrel.
  • the opening 36 is in communication with the chamber 32 and an orifice 39 located at the distal end 20 of the syringe barrel.
  • a tip 40 for attaching a needle, nozzle or tubing for expelling the liquid contained within the syringe barrel 30 is integrally formed with the distal end 20 of the barrel and in communication with the orifice 39.
  • the tip may include coaxially positioned inner 41 and outer 42 members. According to one embodiment the tip may include a Luer taper fitting.
  • the tip may be configured based on the type of drug that the syringe is used to deliver. For example, oral tips may be used on syringes configured for medicines that are oral, and in particular, the oral tip may be different from an intravenous ("IV”) or
  • IM intermuscular
  • syringes configured for IV and IM drugs may be configured with IV and F tips, respectively, such that they, too, can only be delivered via the right route.
  • the plunger 50 includes a plunger rod 51 and a rubber or plastic gasket or stopper 52 attached to the distal end 56 of the plunger rod.
  • the gasket forms a tight seal between the inner surface of the barrel and the plunger in order to prevent the contents of the syringe from escaping out the back of the syringe.
  • An annular flange 53 is integrally formed with the proximal end 55 of the plunger rod.
  • the plunger 50 has an elongate shape complementary to that of the chamber 30 and is designed such that it can be pushed along the chamber (inside of the cylindrical barrel or tube) allowing the syringe to expel fluid through the tip 40 or orifice 39 at the distal end of the barrel.
  • the plunger can include any other configuration capable of forcing the fluid from inside the chamber 30 through the tip 40 or orifice 39.
  • the medicine dosing device may be prefilled with a pre-selected drug. Initially, when the medicine dosing device is prefilled and the syringe is in the pre-medication administration position, the substantial length of the plunger rod extends longitudinally outside of the syringe barrel. In other words, as shown in FIG 1 A, prior to the administration of the medicine, only the gasket 52 and the distal end 56 of the plunger rod are initially inside the syringe barrel, at the proximal end 35 of the barrel, with the remaining part of the plunger length outside of the barrel such that its proximal end 55 is in its most extended configuration.
  • the medicine dosing device may not be prefilled.
  • the medicine dosing device may be marked, for example, with a drug name, concentration, volumetric markings, color coded zones, and/or the like.
  • a medical professional may draw the drug (i.e., the drug with the name marked on the device) with the proper concentration into the medicine dosing device to reach the appropriate volumetric markings and/or color coded zones.
  • the medicine dosing device comes as a part of a kit that includes a medicine vessel containing the drug to be administered. The drug in the medicine vessel may be drawn into the medicine dosing device immediately prior to the drug administration process.
  • the plunger rod may remain inside the syringe barrel until the drug is drawn into the syringe.
  • the medicine dosing devices may be marked clearly. As discussed further below, such markings may include different colored plungers in order to avoid confusion.
  • a kit containing etomidate and succinocholine could have a red plunger for use with etomidate and a blue one for use with succinocholine.
  • syringe 15 may include an elongate barrel 70 and a plunger 80 marked with predetermined color-coded volumetric medicine doses 100 and prefilled with a fluid 105 that corresponds to a medication to be administered to a patient.
  • the syringe barrel includes an inner tubular body 75 that is generally coaxially aligned with the larger diameter of the cylindrical barrel.
  • the inner tubular body has a needle 76 coaxially positioned within the inner tubular body and longitudinally aligned with the inner tubular body.
  • the plunger 80 shown in FIG. 2D, includes a substantially cylindrical member or vial 81 and a stopper 82.
  • the plunger 80 needs to be inserted into the proximal end 35 of the syringe barrel, such that the stopper 82 fully engages with the inner tubular body 75 and the needle 76.
  • the plunger and/or plunger stopper can be color coded based on the medication contained in the barrel. Such color coding of the plunger can further increase efficiency with which medication is administered and can make the administration even less error prone as visual inspection of the plunger can provide a quick verification of the correctness of the medication to be administered.
  • the plunger and/or plunger stopper may be further marked with the name and/or concentration of the drug to further limit the possibility that a mistake is made.
  • the medicine dosing device can include any vessel, such as for example tube, vial, bag or bottle, capable of containing therein and expelling therefrom a desired medicine.
  • the medicine dosing device could be a bag containing an IV fluid.
  • the bag may be marked with a series of color coded zones along with the traditional volume markings.
  • the color coded zones could serve as a reminder to the medical personnel of a correct volume of each medication that can be given to a patient based on the patient's color zone.
  • the color coded zones may also be used as a key for entering a correct total volume to be dispensed into the IV pump for a given medication.
  • the markings may be placed along a circumferential surface of the syringe barrel or plunger.
  • the markings include a series of substantially translucent bands or zones 100 indicative of the possible medicine doses to be administered to a patient.
  • the markings shown in the figures include a series of color coded zones, the markings could also include zones with different patterns, textures, etc.
  • the markings are either directly imprinted, painted, etched or stained on an inside or outside surface of the medicine dosing device or a label or sleeve may be generated that can be affixed or placed over the outer surface of the medicine dosing device.
  • the applied markings are such that the fluid level, once the device is filled, can be easily seen through the markings.
  • FIG. 3 A shows a plurality of labels in accordance with one embodiment of the current disclosure.
  • Each label 300 is substantially rectangular in shape and is sized based on the volumetric capacity of the medical dosing device to which the label is to be affixed.
  • the size or dimensions of the label is adjusted accordingly to ensure that it properly covers the outer surface of the of the medical dosing device. For example, when labels are made for syringes with two different volumetric barrel capacities, the label size is either increased or decreased in both length and width to accommodate for the changes in the outer surface of the barrel.
  • the width of the color bands 351 A - 359A on the label 310 for the 10 cc device would be smaller than the color bands 35 IB - 359B on the label 305 for the 5 cc dispensing device in order to deliver the same amount of medication to the patient.
  • the concentration of the medication that is used also affects the widths of the color bands or zones printed on the label. More specifically, the widths of the color bands or zones are determined based on the concentration of the medication, with the medication at a higher concentration corresponding to a smaller volumetric dose, or smaller band width, than the medication at a lower concentration.
  • the label 300 has opposing parallel sides 315 and 320 and opposing parallel ends 325 and 330 and includes a series of consecutive color bands or zones 351 through 359 of varying widths that correspond to the medication doses for patients with a particular characteristic.
  • the characteristic may correspond to patient length (as discussed above), patient weight, patient age, patient surface area/volume, and/or the like.
  • each color band has a width that is defined by leading 335 and trailing 340 edges that are parallel to the opposing ends 325 and 330 of the label and which, once the label is affixed to the medicine dispensing device, corresponds in volume to a predetermined dose of medicine appropriate for the patient having a characteristic that falls within a predefined color-coded range.
  • each color band or zone on the label represents a medication dose correlated to respective color-coded length range, weight range, age range, surface area/volume range, or other physiological characteristic.
  • nine distinct color bands 351- 359 can be used to distinguish between nine different doses of medication corresponding to nine distinct color coded patient characteristic ranges. More specifically, each of the colors corresponds to one of nine different doses of a specific medication. As shown in the FIG. 3C, in one particular implementation, band colors may include grey 351, pink 352, red 353, purple 354, yellow 355, white 356, blue 357, orange 358 and green 359, with the grey color band
  • a solid black lines 365 may be utilized at the boundaries between the various color bands or zones to facilitate the process of drug administration as will be discussed in more detail below. Although, the discussion will be made with reference to the specific colors shown in the FIGS. 3A-3C, it can be readily appreciated that other colors or markings may be used. Alternatively or additionally, color names may be printed within the band or zone widths in addition to or instead of colors.
  • a label may include ten different bands of colors with the tenth band 360 corresponding to the largest dose of medication that can be delivered.
  • the largest dose can correspond to the universal dose that can be delivered to any patient whose characteristic (e.g., length, weight, etc.) falls outside of the previously disclosed colored ranges.
  • the universal label in accordance with this embodiment can be applied to the universal medicine-dosing device that can be used for both pediatric and adult patients and as such eliminates a need for having two separate medicine dosing systems for the two distinct patient groups.
  • the previously defined bands or zones can be further subdivided into sub-band or sub-zone to allow for a more precise medicine dosing.
  • one of the label edges can include a mark 370 that would help ensure that the label is correctly affixed or positioned on the syringe or plunger.
  • the label edge that is to be aligned with the distal end of the syringe barrel can be marked in order to prevent affixing the label to the barrel in the reverse direction, and thus leading to the incorrect doses being administered at a later time.
  • the edge of the label with the color band corresponding to the smallest dose can include a mark at its leading edge that facilitates the alignment of the label with a distal end of the syringe barrel.
  • the label may include the name of the medication that is to be administered or any other information that maybe important to ensuring that a correct medication would be administered to the patient.
  • the name of the medication can be imprinted along the length of the label or any other position as long as it provides for an easy verification of the correctness of the medicine in the medicine-dosing device.
  • the label may be marked with the corresponding time interval, or a separate calendar, either paper or electronic, may be provided such that the patient and/or medical professionals can keep track of dosing intervals.
  • the method 400 may include generating of a color-coded dose label that can be applied to a selected medical dosing device.
  • the method 400 begins at step 401 during which the selection of the medicine for which the dosing label is to be generated is made.
  • some of the most commonly used medications include, for example, atropine, lidocaine, fentanyl, epinephrine, etomidate, ketamine, succinylcholine, rocuronium, and midazolam to name a few.
  • the method can be equally applied to any other medication that can be administered using the disclosed medicine dispensing device.
  • the doses of the drug for each of the color coded characteristic (e.g., length, weight, etc.) zones previously discussed is determined at step 402.
  • the width of the color coded zones may differ.
  • Table 1 below provides doses in mg for some of the above listed drugs.
  • the doses for each drug differ not only based on the type of the drug but also based on the length (i.e., characteristic) of the patient.
  • a dose for a patient falling within the yellow color-coded length zone is 26 mg for succinylcholine and 13 mg for rocuronium.
  • two different medication doses would be used as shown.
  • doses of the drug may be determined based on dosing recommendations other than those based on the length of the patient, such as, for example, the patient's weight, age, surface area/volume, and/or the like.
  • the drug concentration for the drug selected in step 401 is then determined at step 403.
  • the concentration of the drug is directly related to the volume that needs to be administered. In other words, a smaller volume of the same medication needs to be administered for a solution with a higher concentration than for a solution with a lower concentration.
  • step 404 involves selection of a medicine dispensing device to which the label is to be applied.
  • a medicine dispensing devices conversion factor that is based on the length and width of the medicine dosing device and/or the concentration of the medication may be used to take into account the variations in size and/or shape of different medicine dispensing devices for which the label is to be generated.
  • a corresponding conversion factor listed in Table 1 can be used in order to calculate both the individual color band/zone widths and a total band widths that correspond to the determined medication doses (step 405).
  • each color band/zone that corresponds to the determined medication dose is calculated based on the dose of the drug to be administered, the solution concentration and medicine dispensing device volumetric capacity. According to one embodiment all of the calculations may be performed by a computer processing unit (CPU) in response to a user provided input.
  • CPU computer processing unit
  • Applying of the label to the medicine dosing device may take place once the width of each color band or zone is determined and the label is printed.
  • the label when the label is to be applied to a syringe having a barrel and a plunger, with the barrel designed for holding the medicine that is to be dispensed, the label may be place along the outer circumferential surface of the barrel by aligning one of the edges of the label that corresponds to a color band of the smallest dosing with the distal edge of the syringe barrel of the medicine dispensing device 10.
  • the label may be placed along the outer circumferential surface of the plunger by aligning one of the edges of the label that corresponds to a color band of the smallest dosing with the proximal end of the medicine dosing device.
  • the pre-calculated band/zone widths for each of the selected medication, medicine dispensing device volumetric capacity and solution concentration may be printed on a label that can be applied to the medicine dispensing device, the dosing information may also be directly imprinted, etched, stained or painted on the medicine dispensing device. Alternatively, the dosing information can be printed on a sleeve that can be placed over the medicine dispensing device.
  • the appropriately labeled medicine-dosing device may be prefilled with a desired medication, with the fluid volume corresponding to the maximum dose that can be administered to the patient whose, for example, length falls within the maximum length zone.
  • the medicine dosing unit When the medicine dosing unit is prefilled with the selected medication the label can be applied either before or after the medicine dosing device is filled.
  • the medicine dosing device is filled with a selected medication immediately prior to the medication administration process, as might be the case when the medicine dosing device is included as a part of a kit that includes the medical dosing device and a vessel filled with a drug to be administered, an empty pre-labeled medicine dosing device is supplied for use. Accordingly, a fluid volume that corresponds to a predetermined dose for a given patient may be drawn into the pre-labeled medicine dosing device from the container immediately prior to drug administration.
  • FIG 5 is a flow diagram 500 of a method for administering drugs to a patient using the disclosed medicine dosing device 10 according to one embodiment.
  • the disclosed method provides steps for efficiently administering a selected medicine to a patient from a prefilled and pre-marked medicine dosing device.
  • the method begins at step 501 at which a color-coded length or any other physical characteristic of the patient is determined.
  • a Broselow tape or any other similar type of instrument that provides color-coded length ranges can be used at this step.
  • the color coded length may be obtained by placing a patient 600 along the tape 601 and noting the color-coded length of the patient on the tape.
  • any other physiological characteristic such as for example, weight, age, body surface area or volume, that can be color coded and correlated to medication doses can be used.
  • a prefilled medicine dispensing device 10 containing medication to be administered is selected at step 502.
  • the medication selection is verified by either reading the name of the medication imprinted along the outer surface of the pre-filled medicine dispensing device or by verifying the color of the plunger rod as discussed above.
  • the appropriate dose of medication to be dispensed or its corresponding volume is determined at step 503. The appropriate dose may be determined by a physician or other medical professional who calculates the appropriate dose based on at least one patient characteristic.
  • the calculated dose may be a precise amount of a drug to be administered.
  • the physician or other medical professional who administers the medication may determine a color code for the patient based on at least one patient characteristic. For example, if the patient length or other characteristic is determined as falling within the blue color range on the measuring tape, the volume of medication to be administered to the patient will be the volume within the blue color band or zone on the medicine dosing device.
  • the medicine dispensing unit is prefilled with medication
  • the appropriate dose of medicine can be obtained by purging any excess of medication from the prefilled syringe until the determined/calculated volume (dose) of the medication is reached as indicated in step 504.
  • the prefilled volume of the medicine dispensing device may correspond to the maximum dose that can be administered to a patient. Therefore, unless the calculated dose is the maximum possible dose, some of the medication has to be purged from the prefilled medicine-dosing device prior to administering of the drug.
  • the plunger is pushed along the inside of the barrel toward the distal end 31 of the barrel until the proximal end of the plunger 54 arrives at the calculated dose.
  • the administering medical professional verifies that the calculated dose, and the amount of medication that remains in the medicine dosing device, is within the color coded range determined for the patient.
  • the plunger is pushed toward the distal end of the barrel until the distal end of the plunger is aligned with the calculated dose, and then the administering medical professional ensures that the plunger is between the leading edge and trailing edge of the blue band.
  • determining the dosage for pediatric patients involves first determining the number of milligrams of a drug to give to the patient based on their weight and/or height. Next, the number of milliliters of the drug to give the patient must be determined based on the concentration of the medication. As a result, there is a risk of human error involved in performing the calculations necessary to determine a proper dosage. In addition, errors can arise when medical personnel, often in emergency situations, grab or otherwise a select a syringe having different units than those contemplated by the calculations. These errors can be compounded when treating a patient with a sequence of drugs, i.e., when multiple medications are being administered.
  • kits of the type described herein may reduce some or all of these risks.
  • the use of such kits may help to ensure that correct dosages are administered using the correct timing and sequencing.
  • the use of the present kits helps to ensure that appropriate antidotes and the like are available in the event of any errors in dosing or sequencing.
  • the kits may be available based on the drug(s) and/or treatment(s) to be administered.
  • kits may include one or more of: a medication, a plurality of medications, medication dosing devices, and/or the like.
  • the kits may also include instructions and an instrument, such as a Broselow tape or any other similar type of device, that provide color-coded length ranges as discussed above with reference to FIG. 6.
  • an instrument such as a Broselow tape or any other similar type of device, that provide color-coded length ranges as discussed above with reference to FIG. 6.
  • the medications and/or medication dosing devices may be labeled accordingly.
  • the first medication to be administered and the corresponding medication dosing device may be labelled " 1”
  • the second medication and corresponding medication dosing device may be labelled "2,” and so on.
  • the antidote medication and the antidote dosing device may be labelled accordingly.
  • the medication may be stored in a vial, and the medication dosing device may be a syringe, such as the syringe discussed above with respect to FIGS. 1-3.
  • one or all of the medications may be stored within a syringe.
  • the syringes may be customized for each drug. Syringes with different volumetric capacities may be used depending on the medication.
  • the label size and width of floor bands or zones varies depending on the drug and/or drug concentration. Accordingly, the name of the medication and the concentration of the medication to be used with that syringe may be printed on the syringe (or on the label that is placed on that syringe).
  • the medicine-dosing device can be used to administer drugs to patients following the method shown in FIG. 7A.
  • the method for administering drugs can begin with the selection of an emergency medical treatment kit that includes a drug to be administered to the patient (step 701).
  • the medical treatment kit may include a container, such as box, bag, pouch or any other suitable container capable of holding the medicine dosing device therein, labeled on the outside surface with the name of the medication contained in the container among other things.
  • the label may also include information on the concentration of the drug and/or instruction on how to use the kit to administer the drug.
  • the medical treatment kit may further include a pre-marked medicine dosing device, such as for example a syringe, with the color-coded zones calibrated to the different drug doses for the selected drug.
  • a pre-marked medicine dosing device such as for example a syringe
  • the syringe markings may also include the name of the drug that is to be delivered or any other information that may be helpful in ensuring that the drug is correctly delivered to the patient.
  • the medical treatment kit may also include a needle, such as a blunt filling needle that can be plastic or made of any other suitable material, for facilitating drawing of the drug into the syringe.
  • the medical treatment kit may also contain a container, such a bottle, vial, etc, for holding the drug that is labeled with the drug name on the outside of the container.
  • the container may include a stopper or a lid that helps to contain the drug inside the container.
  • the stopper or lid may be made from, for example, rubber or any other suitable material that can be easily punctured with the filling needle, such that the drug from the container can be easily drawn into the medicine-dosing device.
  • the corresponding vials and syringes for each drug may be positioned within the packaging to ensure that there is no confusion as to which vial corresponds to which syringe.
  • differently colored plungers may be used in order to ensure that the correct medication is given to the patient in the correct order.
  • the kit may include a first drug in a first vial with a first syringe marked with the color zones for the first drug, and a second drug in a second vial with a second syringe marked with the color zones for the second drug.
  • the plungers in the syringes may be colored.
  • the color of the label and/or lid of the first vial may be marked with the same color as the plunger of the first syringe
  • the color of the label and/or lid of the second vial may be marked with the same color as the plunger of the second syringe.
  • the ends of the plungers may be marked numerically to indicate the order in which the drugs are to be delivered. For example, if the first drug to be administered has a green plunger and the second drug to be administered has a yellow plunger, the end of the green plunger may have a number "1" on the end and the end of the yellow plunger may have a number "2" on the end.
  • the vials may also be marked numerically.
  • the color-coded length of the patient may be determined (step 702) using an instrument such as a Broselow tape or any other similar type of device that provides color-coded length ranges as discussed above with reference to FIG. 6. Alternatively, other patient characteristics may be used to determine a color coded range.
  • Appropriate volume of the drug to be administered may be subsequently determined based on the patient length, and the patient length may be correlated to a color code (step 703).
  • the determined drug volume may be then drawn into the medicine-dosing device (step 704), and the administering medical professional verifies that the determined drug volume is within the color code corresponding to the patient (step 705).
  • the drug can then be administered to the patient (step 706).
  • the medicine-dosing device is a syringe with a pre-attached filling needle
  • the filling needle might be disposed of prior to the administration of the medication.
  • FIG. 7C shows an exemplary kit 720 that may be configured to treat anaphylaxis. It may also treat allergies and/or asthma.
  • a kit may contain a vial 725 of epinephrine that has a certain concentration.
  • the epinephrine may have a concentration of 1 : 1000 mg/ml.
  • a syringe 730 (dosing device) may be provided with permanent needle attached thereto in order to ensure the medication is not mistakenly given intravenously.
  • the syringe may have a maximum volume of 0.33 mL.
  • the maximum volume of the syringe may be the maximum pediatric dose of epinephrine, or the maximum volume may be slightly larger than the maximum pediatric dose of epinephrine.
  • the syringe is marked, such as with the color coding discussed above, to indicate the correct dose. In some embodiments, the correct dose may be determined based on the child's weight, age, surface area, and/or length.
  • An instrument 735 such as a Broselow tape or any other similar type of device, that provides color-coded length ranges (e.g., as discussed above with reference to FIG. 6) may also be included in the kit.
  • Instructions 740 may also be included in the kit.
  • the kit may be packaged within a container/package 745. In some embodiments, at least a front side of the packaging may be clear, hard plastic so that the contents are visible and in a particular order.
  • kits 750 are shown in FIG. 7D.
  • the kit 750 may be configured for rapid sequence intubation, which may involve a sequence of medications, such as etomidate, succinopcholine, atropine, and lidocaine.
  • the kit 750 includes three medications. Each medication may be stored in a vial 755a, 755b, 755c, and each vial 755a, 755b, 755c has a corresponding syringe 760a, 760b, 760c.
  • the syringes 760a, 760b, 760c are each calibrated to one of the medications, where syringe 760a is calibrated to the medication in vial 755a, syringe 760b is calibrated to the medication in vial 755b, and syringe 760c is calibrated to the medication in vial 755c.
  • the calibration is based on color coding, where the color coding correlates to the child's weight, age, surface area, and/or length.
  • an instrument 765 such as a Broselow tape or any other similar type of device, that provides color-coded length ranges (e.g., as discussed above with reference to FIG. 6) may also be included in the kit.
  • the instrument 765 is used to determine the color range to which the vial should be filled with the medication.
  • Instructions 770 may also be provided.
  • the instructions 770 may list one or more of the following steps: measure the child's weight, age, surface area, and/or length; determine a color based on the measurement; give medication 1 based on the appropriate color; give medication 2 based on the appropriate color; give medication 3 based on the appropriate color.
  • each corresponding vial-syringe pair may be included within another set of packaging in order to ensure that the vial-syringe pairs are not confused.
  • the vial-syringe pairs may be labelled numerically (e.g., the vial with the first medication and the corresponding syringe are each labelled with the number 1 and so on) and/or the syringe may be marked with the corresponding drug and concentration.
  • the vial- syringe pairs may also be marked with a unique symbol, wherein the unique symbol is only used for that vial-syringe match or wherein the unique symbol is only used for a single drug at a particular concentration.
  • the person administering the drug should check to ensure that the symbol, number, etc. match before administering the drug.
  • Kits may be configured to contain various combinations of medication for any pediatric medical condition.
  • Another exemplary kit may be a supra-ventricular tachycardia kit, which may include a vial of atropine in a correct concentration, a syringe for a first dose at lx mg/kg, a second syringe for a second dose at 2x mg/kg, instructions, a container to keep the contents in order, and/or the like.
  • Other exemplary kits may be configured for moderate sedation, acute pain, and other procedures.
  • kits may also be generated to treat adults, such as
  • the treatments/medications that vary based on the size, weight, etc. of the adult.
  • adult doses are universal; for others, doses may differ based on patient size.
  • the concept is similar to that of pediatric patients, where a larger patient gets a bigger dose and a smaller patient gets a smaller dose.
  • the size differentiation may be based on patient weight, length, surface area, age, and/or the like.
  • some medications have two doses - one for large adults, and one for small adults.
  • drug delivery device may have two zones.
  • Other medications may require more precision based on patient size, and therefore the drug delivery device may have more than two zones.
  • the zones may be color coded (see Fig. 7E); in other implementations, the zones may be clear (see Fig. 7F).
  • Kits similar to those discussed above may be configured to contain vials and/or syringes configured for adults instead of children.
  • the drug devices, drugs, and/or drug may be configured to contain vials and/or syringes configured for adults instead of children.
  • concentrations may be configured for adults. Kits may be clearly labeled to indicate that they are adult kits or pediatric kits.
  • kits may include both a pediatric syringe and an adult syringe.
  • the kit may include a vial of the drug, a corresponding syringe for pediatric patients, and a corresponding syringe for adult patients.
  • the syringes may be clearly labeled as being an adult syringe or pediatric syringe.
  • the syringes may also have a color or symbol designation to indicate adult or pediatric syringe.
  • adult syringes may have a blue plunger and pediatric syringes may have a red plunger, and/or adult syringes may be labelled "A” for adult and pediatric syringes may be labeled "P” for pediatric or "C” for child(ren)).
  • the pre-labeled medicine dispensing device and the method of making and using it offers several advantages over the currently used systems and methods.
  • the pre-marked medicine dispensing device allows to administer medication more accurately as compared to any of the currently available systems.
  • eliminating the step of calculating doses that need to be administered in the high stress environment, as well as eliminating the steps of selecting appropriate medicine dosing device helps to eliminate critical dosing errors, such as critical over dose or critical under dose errors, that usually arise when conventional devices and methods are used.
  • frequency and severity of non-critical errors as compared to the traditional methods can be reduced as shown in FIGs. 8C and 8D.
  • time to prepare and deliver medication, as well as time to deliver medications when preparing for rapid sequence intubations (RSI) may be significantly reduced when the medicine-dosing device according to the current disclosure is used as compared to the conventional devices.
  • the pre-labeled medicine dispensing device designed and used in accordance with the disclosed embodiments provides for more simplified, accurate and efficient drug delivery in emergency and critical care situations.
  • Example embodiments of the devices, systems and methods have been described herein. As may be noted elsewhere, these embodiments have been described for illustrative purposes only and are not limiting. Other embodiments are possible and are covered by the disclosure, which will be apparent from the teachings contained herein. Thus, the breadth and scope of the disclosure should not be limited by any of the above-described embodiments but should be defined only in accordance with claims supported by the present disclosure and their equivalents. Moreover, embodiments of the subject disclosure may include methods, systems and devices which may further include any and all elements/features from any other disclosed methods, systems, and devices, including any and all features corresponding to scientific data exchange.
  • features from one and/or another disclosed embodiment may be interchangeable with features from other disclosed embodiments, which, in turn, correspond to yet other embodiments.
  • one or more features/elements of disclosed embodiments may be removed and still result in patentable subject matter (and thus, resulting in yet more

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Abstract

L'invention concerne, dans certains aspects, un système d'administration de médicaments. Dans un aspect, l'invention concerne une trousse comprenant un dispositif médical d'administration pourvu d'une étiquette comprenant une série de zones de largeur variable, chaque zone correspondant à une dose volumétrique prédéterminée du médicament corrélée à une des caractéristiques physiques d'un patient. Dans un exemple spécifique, l'étiquette est en outre fixée sur le dispositif d'administration de médicament, de sorte que la plus petite dose du médicament à administrer corresponde à une première zone située à proximité d'une ouverture à travers laquelle le médicament va être distribué.
PCT/US2017/031420 2016-05-05 2017-05-05 Appareils, procédés et systèmes pour administrer des médicaments au moyen de trousses de médicaments WO2017193082A1 (fr)

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MX2018013503A MX2018013503A (es) 2016-05-05 2017-05-05 Aparatos, métodos y sistemas para administrar medicamento utilizando kits de medicamento.
AU2017261355A AU2017261355B2 (en) 2016-05-05 2017-05-05 Apparatuses, methods, and systems for delivering medication using medication kits
EP17793509.5A EP3452147A4 (fr) 2016-05-05 2017-05-05 Appareils, procédés et systèmes pour administrer des médicaments au moyen de trousses de médicaments
CN201780037854.9A CN109641106B (zh) 2016-05-05 2017-05-05 使用药物试剂盒递送药物的装置、方法和系统
KR1020187035175A KR102638625B1 (ko) 2016-05-05 2017-05-05 약제 키트들을 사용하여 약제를 전달하기 위한 장치들, 방법들 및 시스템들
JP2018557892A JP7297446B2 (ja) 2016-05-05 2017-05-05 投薬キットを用いて医薬品を送達するための装置、方法及びシステム
CA3023362A CA3023362A1 (fr) 2016-05-05 2017-05-05 Appareils, procedes et systemes pour administrer des medicaments au moyen de trousses de medicaments
JP2022041520A JP2022079520A (ja) 2016-05-05 2022-03-16 投薬キットを用いて医薬品を送達するための装置、方法及びシステム

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US15/282,732 2016-09-30
US15/282,732 US11617835B2 (en) 2012-02-01 2016-09-30 Apparatuses, methods, and systems for delivering measured doses of medication

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US11617835B2 (en) 2012-02-01 2023-04-04 Cd Acquisitions, Llc Apparatuses, methods, and systems for delivering measured doses of medication
US11679204B2 (en) 2018-05-17 2023-06-20 Cd Acquisitions, Llc Syringe holder for medication dosing
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AU2017261355B2 (en) 2021-12-09
EP3452147A4 (fr) 2020-05-06
JP2019514588A (ja) 2019-06-06
MX2018013503A (es) 2019-07-04
AU2017261355A1 (en) 2018-11-22
CN109641106B (zh) 2022-07-05
JP2022079520A (ja) 2022-05-26
CA3023362A1 (fr) 2017-11-09
KR102638625B1 (ko) 2024-02-19
KR20190017765A (ko) 2019-02-20
CN109641106A (zh) 2019-04-16
EP3452147A1 (fr) 2019-03-13
JP7297446B2 (ja) 2023-06-26

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