WO2017188908A1 - Stent en alliage métallique implanté par voie intraveineuse et nouveau procédé de production de ce stent - Google Patents

Stent en alliage métallique implanté par voie intraveineuse et nouveau procédé de production de ce stent Download PDF

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Publication number
WO2017188908A1
WO2017188908A1 PCT/TR2017/050159 TR2017050159W WO2017188908A1 WO 2017188908 A1 WO2017188908 A1 WO 2017188908A1 TR 2017050159 W TR2017050159 W TR 2017050159W WO 2017188908 A1 WO2017188908 A1 WO 2017188908A1
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WO
WIPO (PCT)
Prior art keywords
production
stent
alloy
tray
laser
Prior art date
Application number
PCT/TR2017/050159
Other languages
English (en)
Inventor
Fehim FINDIK
Cuma Bindal
Ramazan AKDEMIR
Osman IYIBILGIN
Mahmut OZACAR
Azim GOKCE
Original Assignee
Findik Fehim
Cuma Bindal
Akdemir Ramazan
Iyibilgin Osman
Ozacar Mahmut
Gokce Azim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Findik Fehim, Cuma Bindal, Akdemir Ramazan, Iyibilgin Osman, Ozacar Mahmut, Gokce Azim filed Critical Findik Fehim
Publication of WO2017188908A1 publication Critical patent/WO2017188908A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/20—Direct sintering or melting
    • B22F10/28—Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/30—Process control
    • B22F10/32—Process control of the atmosphere, e.g. composition or pressure in a building chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/30—Process control
    • B22F10/36—Process control of energy beam parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F12/00—Apparatus or devices specially adapted for additive manufacturing; Auxiliary means for additive manufacturing; Combinations of additive manufacturing apparatus or devices with other processing apparatus or devices
    • B22F12/40—Radiation means
    • B22F12/44—Radiation means characterised by the configuration of the radiation means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C33/00—Making ferrous alloys
    • C22C33/02—Making ferrous alloys by powder metallurgy
    • C22C33/0257—Making ferrous alloys by powder metallurgy characterised by the range of the alloying elements
    • C22C33/0278—Making ferrous alloys by powder metallurgy characterised by the range of the alloying elements with at least one alloying element having a minimum content above 5%
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C38/00—Ferrous alloys, e.g. steel alloys
    • C22C38/002—Ferrous alloys, e.g. steel alloys containing In, Mg, or other elements not provided for in one single group C22C38/001 - C22C38/60
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C38/00—Ferrous alloys, e.g. steel alloys
    • C22C38/02—Ferrous alloys, e.g. steel alloys containing silicon
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C38/00—Ferrous alloys, e.g. steel alloys
    • C22C38/04—Ferrous alloys, e.g. steel alloys containing manganese
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C38/00—Ferrous alloys, e.g. steel alloys
    • C22C38/10—Ferrous alloys, e.g. steel alloys containing cobalt
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C38/00—Ferrous alloys, e.g. steel alloys
    • C22C38/12—Ferrous alloys, e.g. steel alloys containing tungsten, tantalum, molybdenum, vanadium, or niobium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/16—Materials with shape-memory or superelastic properties
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/25—Process efficiency

Definitions

  • a bio-degradable and shape memory material is used within the scope of the invention. Similar materials are also used in prior art.
  • EP2398521 available in current art.
  • This stent is formed by a composition that is composed of Fe, Mn, Si and C. This material does not have shape memory feature. It can only be used in balloon expansion method.
  • a stent made of an iron based allot is mentioned in Chinese Patent document No. CN103974728 available in current art.
  • Such alloy contains Fe-X-Y.
  • X is at least one austenite balancing element selected from the group that is composed of Co, Ni, Mn, Cu, Re, Rh, Ru, Ir, Pt.
  • Y is at least one corrosion activator selected from the group that is composed of Pd and Au.
  • production of bio-degradable (soluble in body) metal stents with 3D printer technology by using shape memory alloys, which are types of smart materials does not involve.
  • the stent developed for achieving such purposes contain Fe-Mn-X-Y alloy.
  • X contains at least one element selected from the group that is composed of S, Co and Mo.
  • Y contains at least one element selected from the group that is composed of C and Pd. Production is performed with 3D printer.
  • the laser power required for combining this alloy by means of melting method is determined. Laser power varies depending on the composition of the stent material and alloy ratios.
  • Mean powder size 5 micron to 20 micron (weighted average -15 micron)
  • Laser power 200-400 W

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Metallurgy (AREA)
  • Mechanical Engineering (AREA)
  • Automation & Control Theory (AREA)
  • Toxicology (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention se rapporte à un stent en alliage métallique tubulaire perméable, qui est placé par voie intraveineuse et assure la continuité du flux à l'intérieur du vaisseau à une vitesse nécessaire en étant dilaté selon une certaine mesure juste après le placement. Un alliage Fe-Mn-X-Y est utilisé pour produire des stents biodégradables, où X contient au moins un élément choisi dans le groupe constitué de Si, Co, Mo et Y contient au moins un élément choisi dans le groupe constitué par C et Pd. Dans ledit alliage, Fe est caractérisé en ce qu'il est présent à un taux de 47 à 75 %, Mn à un taux de 20 à 35 %, Si à un taux de 1 à 6 %, Co à un taux de 1 à 4 %, Mo à un taux de 1 à 4 %, C à un taux de 1 à 2 % et Pd à un taux de 1 à 2 % en poids. L'invention concerne un procédé de production d'un stent en alliage métallique tubulaire perméable, qui est placé par voie intraveineuse et assure la continuité du flux à l'intérieur du vaisseau à une vitesse nécessaire en étant dilaté selon une certaine mesure juste après le placement. Selon l'invention : - la production est réalisée avec une imprimante 3D, - une source laser ayant une puissance de 200 à 400 W est utilisée pendant la production, - des poudres formant l'alliage sont disposées correctement sur un plateau à l'intérieur du bassin de production, - la source laser est disposée fixe à mi-sommet du plateau et de manière à être distante du plateau à une distance focale, - des miroirs sont utilisés pour assurer l'orientation des faisceaux laser sur le point souhaité, - les étapes de traitement comprennent le balayage de chaque couche en dirigeant les faisceaux laser au moyen de miroirs pendant la production et en les combinant d'une manière telle que la géométrie souhaitée est obtenue, la taille moyenne des poudres est de 5 à 20 micromètres, la puissance laser est de 200 à 400 W, la vitesse de balayage est de 10 m/s à 20 m/s, le diamètre du faisceau laser est compris entre 80 µm et 150 µm et la hauteur de la couche est comprise entre 20 µm et 200 µm pendant la production, et l'argon ou l'azote gazeux est utilisé comme atmosphère protectrice pendant la production.
PCT/TR2017/050159 2016-04-25 2017-04-24 Stent en alliage métallique implanté par voie intraveineuse et nouveau procédé de production de ce stent WO2017188908A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2016/05339A TR201605339A2 (tr) 2016-04-25 2016-04-25 Damar İçine Yerleştirilen Metal Alaşımlı Stent ve Bu Stentin Üretimi İçin Yeni Bir Yöntem
TR2016/05339 2016-04-25

Publications (1)

Publication Number Publication Date
WO2017188908A1 true WO2017188908A1 (fr) 2017-11-02

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PCT/TR2017/050159 WO2017188908A1 (fr) 2016-04-25 2017-04-24 Stent en alliage métallique implanté par voie intraveineuse et nouveau procédé de production de ce stent

Country Status (2)

Country Link
TR (1) TR201605339A2 (fr)
WO (1) WO2017188908A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000003611A1 (it) 2020-02-21 2021-08-21 Getters Spa Leghe Fe-Mn-X-Y bioassorbibili pseudoelastiche per impianti medici
IT202000007717A1 (it) 2020-04-10 2021-10-10 Getters Spa Leghe Fe-Mn-Si-X bioassorbibili per impianti medici
WO2022187904A1 (fr) * 2021-03-11 2022-09-15 Newsouth Innovations Pty Limited Alliage à mémoire de forme

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115317210A (zh) * 2022-08-23 2022-11-11 深圳高性能医疗器械国家研究院有限公司 可回收金属支架及其制备方法和使用方法

Citations (5)

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Publication number Priority date Publication date Assignee Title
US20100174367A1 (en) * 2009-01-08 2010-07-08 Bio Dg, Inc Implantable medical devices comprising bio-degradable alloys
US20100217370A1 (en) * 2009-02-20 2010-08-26 Boston Scientific Scimed, Inc. Bioerodible Endoprosthesis
US20130103161A1 (en) * 2011-10-20 2013-04-25 Medtronic Vascular, Inc. Iron Based Alloys for Bioabsorbable Stent
US20150010422A1 (en) * 2013-07-03 2015-01-08 Medtronic Vascular, Inc. Methods of Manufacturing a Drug-Eluting Stent
US9114032B1 (en) * 2014-05-21 2015-08-25 Medtronic Vascular, Inc. Method of making a stent

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US20100217370A1 (en) * 2009-02-20 2010-08-26 Boston Scientific Scimed, Inc. Bioerodible Endoprosthesis
EP2398521A2 (fr) 2009-02-20 2011-12-28 Boston Scientific Scimed, Inc. Endoprothèse bioérodable
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CN103974728A (zh) 2011-10-20 2014-08-06 美敦力瓦斯科尔勒公司 用于可生物吸收的支架的铁基合金
US20150010422A1 (en) * 2013-07-03 2015-01-08 Medtronic Vascular, Inc. Methods of Manufacturing a Drug-Eluting Stent
US9114032B1 (en) * 2014-05-21 2015-08-25 Medtronic Vascular, Inc. Method of making a stent

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Title
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000003611A1 (it) 2020-02-21 2021-08-21 Getters Spa Leghe Fe-Mn-X-Y bioassorbibili pseudoelastiche per impianti medici
WO2021165333A1 (fr) 2020-02-21 2021-08-26 Saes Getters S.P.A. Alliages fe-mn-x-y pseudo-élastiques biorésorbables pour implants médicaux
IT202000007717A1 (it) 2020-04-10 2021-10-10 Getters Spa Leghe Fe-Mn-Si-X bioassorbibili per impianti medici
WO2021204811A1 (fr) 2020-04-10 2021-10-14 Saes Getters S.P.A. Alliages fe-mn-si-x biorésorbables pour implants médicaux
WO2022187904A1 (fr) * 2021-03-11 2022-09-15 Newsouth Innovations Pty Limited Alliage à mémoire de forme

Also Published As

Publication number Publication date
TR201605339A2 (tr) 2017-02-21

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