WO2017181287A1 - Système et procédé personnalisés de distribution de médicaments, et distributeur associé - Google Patents

Système et procédé personnalisés de distribution de médicaments, et distributeur associé Download PDF

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Publication number
WO2017181287A1
WO2017181287A1 PCT/CA2017/050495 CA2017050495W WO2017181287A1 WO 2017181287 A1 WO2017181287 A1 WO 2017181287A1 CA 2017050495 W CA2017050495 W CA 2017050495W WO 2017181287 A1 WO2017181287 A1 WO 2017181287A1
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WIPO (PCT)
Prior art keywords
dispenser
medicament
personalized
health
user
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Application number
PCT/CA2017/050495
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English (en)
Inventor
Francisco Diaz-Mitoma
Saul Mijael Ibaven BUENO
Original Assignee
Bowhead Health, Inc.
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Publication date
Application filed by Bowhead Health, Inc. filed Critical Bowhead Health, Inc.
Publication of WO2017181287A1 publication Critical patent/WO2017181287A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0481—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers working on a schedule basis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0454—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers for dispensing of multiple drugs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/20—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/13—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/20—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L51/00—User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail
    • H04L51/02—User-to-user messaging in packet-switching networks, transmitted according to store-and-forward or real-time protocols, e.g. e-mail using automatic reactions or user delegation, e.g. automatic replies or chatbot-generated messages

Definitions

  • the present disclosure relates to dispensing systems, and, in particular, to a personalized medicament dispensing system and method, and dispenser therefor.
  • a household dispenser developed by Hero Health LLC (Brooklyn, NY) provides automated reminders to household users based on user-configured schedules, and dispenses corresponding vitamins or the like upon dispenser activation in response to these reminders. For instance, ten different vitamins can be stored into respective internal dispenser receptacles, and selectively dispensed therefrom upon user activation based on one or more pre-programmed reminders.
  • Connectivity features and a related mobile device application can expand the reminder and tracking capabilities of the device to a user' s mobile device.
  • an automated personalized medicament dispensing system comprising: a biological sample reader operable to read a biological sample to extract therefrom a health-related indicator; a medicament dosing processor operable to automatically evaluate said health-related indicator to output a personalized intake regimen for a designated medicament predefined to positively impact said health-related indicator; and a dispenser operable in response to said output to dispense a discretely quantifiable dose of said designated medicament according to said personalized intake regimen.
  • a personalized medicament dispenser comprising: respective dispensable storage for measurable quantities of distinct medicaments; a dispensing mechanism operatively associated with each said respective dispensable storage to selectively dispense a measurable quantity of each of said distinct medicaments in accordance with a personalized intake regimen; and a hardware processor operable to receive a current personalized intake regimen in response to a biological sample reading and activate said dispensing mechanism accordingly.
  • An automated personalized medicament dispensing method comprising: electronically reading a biological sample to extract therefrom a health-related indicator; evaluating, in a hardware processor, said health-related indicator to output a personalized intake regimen for a designated medicament or specific mixture of medicaments predefined to positively impact said health-related indicator; and causing a dispenser to automatically dispense a discretely quantifiable dose of said designated medicament according to said personalized intake regimen.
  • an automated personalized medicament dispensing system comprising: a medicament dosing processor operable to automatically evaluate a digital health-related indicator to output a personalized intake regimen for a designated medicament predefined to positively impact said health-related indicator; a digital input interface accessible by said medicament dosing processor and receiving as input said digital health-related indicator for processing; and a dispenser operable in response to said output to dispense a discretely quantifiable dose of said designated medicament according to said personalized intake regimen.
  • a personalized medicament dispenser comprising: respective dispensable storage for measurable quantities of distinct medicaments; a dispensing mechanism operatively associated with each said respective dispensable storage to selectively dispense a measurable quantity of each of said distinct medicaments in accordance with a personalized intake regimen; and a hardware processor operable to receive a current personalized intake regimen in response to a biological sample reading and activate said dispensing mechanism accordingly.
  • an automated personalized medicament dispensing method comprising: electronically accessing a digital health-related indicator extracted from a biological sample reading; evaluating, in a hardware processor, said health-related indicator to output a personalized intake regimen for a designated medicament or specific mixture of medicaments predefined to positively impact said health-related indicator; and electronically causing a dispenser to automatically dispense a discretely quantifiable dose of said designated medicament according to said personalized intake regimen.
  • Figure 1 is a diagram of a personalized medicament dispensing system, in accordance with one embodiment
  • Figure 2 is a diagram of a personalized medicament dispensing system, in accordance with another embodiment
  • Figure 3 is an exploded perspective view of a dispenser for use in a personalized medicament dispensing system, in accordance with one embodiment, with inset Figure 3 A showing a bottom perspective view of a lid portion thereof; and [0019] Figures 4 to 18 are exemplary screenshots of a mobile application operable on a mobile device to interface with a personalized medicament dispensing system, in accordance with one embodiment.
  • the systems and methods described herein provide, in accordance with different embodiments, different examples in which one or more personalized medicament doses can be automatically adjusted and dispensed on the basis of one or more health indicators recently associated with a given user.
  • this user may provide a biological sample that is automatically processed by or in association with the dispenser to characterize one or more designated health indicators and associate therewith an appropriate dose for each of one or more designated medicaments to be dispensed to the user accordingly.
  • appropriate medicament dosing can be adjusted dynamically and dispensed accordingly, thus not only providing direct feedback to the user as to their current health condition by virtue of the processed health indicators, but also promoting intake of appropriate medicament doses given such indicators, rather than to blindly intake constant medicament doses in perpetuity without feedback as to an appropriateness of such doses.
  • a medicament dispensing system in one example that can adapt to each user's personal characteristics using an automated computational process that can, in some configurations, further account for additional personal information such as age, gender, race, health status, history of medical conditions, current prescribed or recommended medicaments, vitamins, minerals or supplements, genetic characteristics, geography and/or other personal information that makes a person or individual different from others.
  • the medicament dispensing system has an electronic and digital board that processes personal user information and can read levels of biomarkers/indicators in body fluids or the like with the purpose of detecting a range thereof that will indicate the need to dispense medicaments in a certain dose range that is personalized to that user.
  • the medicament dispensing system has an electronic and digital communication system that can interact with other electronic devices, such as personalized user wearable devices, mobile user communication devices, remote diagnostic servers and/or systems operated by medical or naturopathic diagnostic, testing or like service provides, and/or other healthcare systems, for example.
  • This interaction can result in the provision of further data or information that can be integrated in the automated computation process to determine a change in the personalized range of medicament dosage suggested or prescribed to the user, for example.
  • current user health indicators may be obtained by various means and processed to output an electronic indication representative of a particular medicament dosing regiment recommended for the user.
  • electronic indicators are processed in situ at the dispenser, direct relay and processing of such indicators by the dispenser will result in an immediate direct update of user dosages.
  • electronic indicators derived by an associated device e.g. mobile user application; distinct user health indicator processing and output device; remote, e.g. lab-based, diagnostic device and server; etc.
  • such indicators may be automatically processed and relayed via direct or indirect, wired or wireless communication means to be execute updated user-specific medicament dose recommendations at the dispenser.
  • a centralized dispensing device e.g. community-based or commercially implemented dispenser
  • each register user device may be communicatively coupled to each register user device and/or a remote health indicator processing server to deliver user-specific doses to a given user based on retrievable user data and associated current personalized dose information.
  • the term “medicament” will be used herein to refer to a quantifiable product selected from any one or more of the following non-exhaustive list of examples: medicine, vitamin, mineral, plant product or derivative, supplement, drug, homeopathic or naturopathic remedy, pharmaceutical, or any combination thereof.
  • the systems and methods described herein go beyond the provision of a simple medicament intake scheduler, reminder and dispenser system, and rather provide a dynamically adjustable personalized medicament dispenser that automatically adjusts each user's dose as a function of one or more characterizable user health indicators.
  • These indicators may, for example, be extracted from a biological sample provided by the user for processing and characterization, and/or by one or more other physiological, geographic and/or demographic health indicators that may be processed alone, or in combination, to impact a particular medicament dose to be dispensed at a particular time or over a particular time period.
  • the biological sample may include, but is not limited to, a sample of the user's saliva (e.g. swab), blood (e.g. via prick or microneedle device), urine (e.g. midstream catch) or other bodily fluid as may be readily appreciated by the skilled artisan, in which individual fluctuations in body parameter levels (e.g. observed surplus, deficiency or adequacy) may be detected and/or measured to correspond with an appropriate medicament intake dose recommended to maintain or adjust such observed levels.
  • saliva e.g. swab
  • blood e.g. via prick or microneedle device
  • urine e.g. midstream catch
  • individual fluctuations in body parameter levels e.g. observed surplus, deficiency or adequacy
  • body parameter levels may include, but are not limited to blood glucose levels, Ph, aminoacids, proteins, DNA or RNA, inflammation markers, cytokines, vitamins, minerals, bacteria, virus, fungus, and parasites, to name a few examples.
  • Current independent and/or correlated physiological parameters such as heart rate, temperature, respiratory rate, expiratory air flow rate, blood pressure, etc. may also or alternatively be taken into account in adjusting medicament doses, as can other demographic, geographic or like indicators such as age, sex, body mass index, weight, height, environment (urban, suburban, rural residency), drinking or smoking habits, reported or measured pollution levels or air quality index, race, ethnicity and the like.
  • collected indicators may be processed locally at the dispenser to output a recommended dosage for each of one or more designated medicaments, or may otherwise be processed remotely via a digital input and communication interface to a network accessible processor and database, whereby remote processing may be executed on locally acquired indicators that are read locally by a local user device (e.g. integrated dispenser bio sample reader and/or separately operable user bio sample reader) and/or a remote reader communicatively linked via a corresponding personalized dispenser communication system and network (e.g. operated by lab-based bio sample testing service provider and/or medicament dispensing or distribution center, etc.).
  • a local user device e.g. integrated dispenser bio sample reader and/or separately operable user bio sample reader
  • a remote reader communicatively linked via a corresponding personalized dispenser communication system and network (e.g. operated by lab-based bio sample testing service provider and/or medicament dispensing or distribution center, etc.).
  • health indicator processing may be more readily benefited from collective data collections and processing, for example, to reflect trends and responses collected from multiple users over time, though similar collective and collaborative approaches may be applied locally upon synching respective devices over a data network or the like, or again upon updating locally stored databases and dose calculation processes via an appropriate live network connection or direct data upload or input through a healthcare worker or facility.
  • similar collective and collaborative approaches may be applied locally upon synching respective devices over a data network or the like, or again upon updating locally stored databases and dose calculation processes via an appropriate live network connection or direct data upload or input through a healthcare worker or facility.
  • the illustrated embodiments described below encompass an integrated biological sample reader, remote or distinct readers or data from vital sign wearable devices or a personal activity tracker device or positional tracker system (chronos wifi) may also or alternatively be considered to achieve a similar effect.
  • a biological reader may be integrally or communicatively coupled to a user's mobile device such that a biological reading therefrom may be processed, either locally using an dedicated application operating on the mobile device, or remotely upon being communicatively relayed by the mobile device to a remote processing site (e.g. centralized processing server and database) or again to the user's dispenser if directly operable to extract or at least process the health indicators so extracted to adjust corresponding medicament doses.
  • the dispenser and reader device will communicate and collect information from a wearable device or positional system to integrate information about a personal range of activity and relative positional information of the user. The received information can then be processed and combined with other health indicators to adjust corresponding personalized medicament dose range(s), for example.
  • biological samples may be collected and dispatched by the user for remote processing, whereby results of such remote processing may be input via an appropriate digital input interface associated with the system (e.g. automated electronic reader-system interface, network indicator input portal, etc.) and automatically relayed to the user's dispenser (directly or via a user's mobile application communicatively linked or linkable to their dispenser), for immediate implementation or upon acknowledgement by the user.
  • an appropriate digital input interface associated with the system
  • the user's dispenser directly or via a user's mobile application communicatively linked or linkable to their dispenser
  • Similar embodiments invoking a communal dispenser e.g. family or residence-based, community-based, commercially operated dispenser, etc.
  • a communal dispenser e.g. family or residence-based, community-based, commercially operated dispenser, etc.
  • the system 100 generally comprises a dispenser 102 operable to dispense respective discretely quantifiable doses of two or more medicaments, such as medicaments 104 and 106, from corresponding refillable or rechargeable containers 108, 110, in accordance with a personalized intake recommendation or prescription.
  • the system further comprises a biological sample reader 114, in this example, integrated within the dispenser 102, that is operable to read a biological sample 116 or the like, for example, produced on a sampling card, strip, cartridge, recipient or the like 117, to extract therefrom one or more health indicators usable in automatically defining the personalized intake recommendation.
  • the integrated reader 114 is operable to automatically read the sample 116 and extract the one or more corresponding health indicators therefrom, which are then communicated via an integrated digital processing device 118 (e.g. hardware processor with embedded software/firmware) and communication interface 120 to a remote server 122 or the like.
  • the dispenser 102 may include a wireless communication interface (e.g. Wi-Fi transceiver) operable to communicate via a local wireless access point 124 (e.g. Wi-Fi enabled home Internet modem or the like) over a secure network connection 126 to the remote server 122.
  • a wireless communication interface e.g. Wi-Fi transceiver
  • a local wireless access point 124 e.g. Wi-Fi enabled home Internet modem or the like
  • the server 122 may be operated to process the user's inbound health indicator(s) against a stored user profile to automatically determine an appropriate medicament intake recommendation and relay this recommendation back to the dispenser 102 to be automatically processed thereby.
  • the server 122 may have operable and/or communicative access to a medicament dosing processor operable to automatically evaluate the extracted health-related indicator(s), in some examples in conjunction with various user-specific or related health, demographic, geographic and/or historical data, to output a personalized dose for one or more designated medicaments predefined to positively impact the extracted health-related indicator(s).
  • a positive impact may be qualified as one which promotes maintenance, increase or decrease of an indicator level, which maintenance, increase or decrease is previously identified to correlate with improved overall health or again promote a healthy improvement in respect of a previously identified, suspected or anticipated ailment, illness or condition.
  • an indicator level which maintenance, increase or decrease is previously identified to correlate with improved overall health or again promote a healthy improvement in respect of a previously identified, suspected or anticipated ailment, illness or condition.
  • a biomarker like vitamin D can be measured in blood or in saliva. If measured levels of 25-hydroxy vitamin D are below 20 nanograms per ml of blood for a given user, for example, this may indicate a vitamin D deficiency, which may result in the automated dispensing of an appropriate vitamin D supplement.
  • the measurement of vitamin D can be particularly important in overweight individuals or in people who have intestinal problems, such as bowel inflammatory disease because even if these individuals take a proper daily recommended dose of vitamin D, the consumption by fat cells or the absorption by the intestine may be defective and cause a vitamin D deficiency, which can be associated with risk of cardiovascular, respiratory, and mental disorders and increased susceptibility to cancer.
  • vitamin B 12 Humans are not able to produce vitamin B12, therefore it needs to be taken from food or supplements. However, certain conditions, such as gastric or intestinal disorders, or people following vegan diets or having certain immune disorders, or again subject to the administration of antiacid medications, can inhibit the absorption of this vitamin. Its deficiency results in pernicious anemia. Therefore, measurement of vitamin B 12 in blood may identify a deficiency, which can be compensated for by the automated dispensing of an appropriate supplement.
  • saliva can be used to measure hormones such as estrogens, progesterone or testosterone or Cortisol. Hormonal imbalances can then be properly corrected by the use of hormonal supplements in the form of creams, gels or oral administration.
  • hormones such as estrogens, progesterone or testosterone or Cortisol.
  • Hormonal imbalances can then be properly corrected by the use of hormonal supplements in the form of creams, gels or oral administration.
  • the measurement of progesterone several times during the menstrual cycle in saliva and detection of levels below 100 pg/ml or outside of a normal pattern would suggest a hormonal imbalance and/or a deficiency and indicate the benefit of administering a hormonal supplement.
  • receipt of the recommended intake regimen may result in the automated dispensing of recommended medicaments 104, 106 in appropriate doses, or again result in an indicator light or display informing the user that the recommended intake doses have been processed and are ready to be dispensed upon user confirmation.
  • the dispenser may only dispense the prescribed dose(s) upon confirmation that the intended recipient is present and ready at the dispenser 102. This may be configured by a user confirmation action such as, but not limited to, pressing a confirmation button or otherwise activating a confirmation function, so to avoid the dispenser delivering the recommended dose to an unintended recipient.
  • the system may further comprise a mobile application 128 executable on a mobile device 130, or the like, which may also or alternatively produce a dose dispensing confirmation function operable by the designated user to release the prescribed dose(s), which function may be configured to communicate user confirmation via a network connection to the dispenser, or again via a direct (e.g. Wi-Fi, near field or Bluetooth) connection, to name a few examples.
  • a mobile application 128 executable on a mobile device 130, or the like, which may also or alternatively produce a dose dispensing confirmation function operable by the designated user to release the prescribed dose(s), which function may be configured to communicate user confirmation via a network connection to the dispenser, or again via a direct (e.g. Wi-Fi, near field or Bluetooth) connection, to name a few examples.
  • a direct e.g. Wi-Fi, near field or Bluetooth
  • the dispenser 102 will proceed to automatically dispense a prescribed quantity of each of the at least one applicable medicaments, in the illustrated embodiment, via respectively controllable valves 132 (e.g. iris valves or the like) associated with an output of each container (e.g. containers 108, 110) and amenable to providing a controllable amount of the contained medicaments in accordance with the prescribed dose(s).
  • controllable valves 132 e.g. iris valves or the like
  • Various output control valves will be known in the art to control the dispensing of different liquids, gels, creams or solids that are shaped, sized and formed according to different medicament delivery media, which may include as noted above, but are not limited to, differently sized and shaped capsules, pills, gelcaps, liquids, powders, granules, creams, pellets, etc.
  • the medicaments may be funnelled 134 or otherwise channelled to a cup 136 or other receptacle for intake by the user.
  • the dispenser 102 may integrate the medicament dosing processor (e.g. as part of integrated digital processing device 118) so to automatically process the extracted indicators directly even in the absence of an available network connection.
  • the medicament dosing processor e.g. as part of integrated digital processing device 118
  • such embodiments may be preconfigured with embedded or stored software/firmware to define appropriate medicament doses, optionally in conjunction with locally stored user-related data and dosing metrics.
  • External updates may nonetheless be provided, for example, via a remote network data/software sync/update, or again via a local input of updated data/software, which may, for example, be loaded onto a disc or USB stick and uploaded to the dispenser 102 directly.
  • the dispenser 202 may rather be configured to interface directly with the user's mobile device 230 and executable application 228 to process extracted health indicators from the biological sample 216.
  • a medicament dosing process may be integrated within the dedicated application 228 so to automatically process the extracted indicators locally without necessarily invoking a remote connection.
  • extracted indicator(s) may be communicated to the user's mobile device 230 or the like (e.g. laptop, tablet, smart watch, etc.) via an appropriate short range or local network connection (e.g. Wi-Fi, Bluetooth, NFC, etc.).
  • the recommended intake prescription may be displayed to the user via the application 228, for example along with related historical data or the like, for confirmation.
  • the recommended intake prescription may be relayed back to the dispenser via a same communication path for automatic processing and dispensing.
  • the mobile application may be routinely or periodically synchronized with a remote server 222 (e.g. via a wireless data network, in this embodiment illustrated as a cellular data network 226) so to maintain up do date prescription metrics and data, and backup the user's local profile, for example.
  • the biological reader may be fully or partially integrated within the mobile device, for example within the context of a wearable mobile fitness device or the like configured to automatically extract biometric/physiological data such as, but not limited to, current and recent heart rate history, respiration rate, blood oxygen levels, body temperature, Ph levels, body activity data, positional signals, sleep patterns, etc.
  • the biological reader may consist of a separate device communicatively linkable to the dispenser (102, 202) and/or mobile device (130, 230), or again configured to relay health-related indicators directly to the server via an appropriate digital interface, for example within the context of a clinical setting or the like.
  • biological samples may be acquired locally or at a clinic and shipped to a sample processing establishment that operates a reader or like equipment, whereby sample processing results may be output a digital health-related indicator that can be input into the system via a corresponding digital input interface and automatically relayed by the system directly to the dispenser and/or via the user's mobile device to affect a medicament intake regimen update.
  • sample processing results may be output a digital health-related indicator that can be input into the system via a corresponding digital input interface and automatically relayed by the system directly to the dispenser and/or via the user's mobile device to affect a medicament intake regimen update.
  • a dynamic database of user and dosage information can be maintained by the server (122, 222) so to provide the most up to date and accurate dosage recommendations possible given extracted indicators, and possibly various other related information such as user and participating population demographics, geographic information, sex, gender, age, health conditions, and the like.
  • Such updated information may be maintained and used to process extracted indicators remotely at the server (122, 222), routinely synchronized for local processing at the dispenser (102, 202) and/or by the dedicated mobile application (128, 228), or again uploaded thereto along with occasional software/firmware/application updates, as may be appropriate given the application at hand and observed variations or trends in observed user data.
  • some embodiments provide for real-time or near realtime assessment of a user's personalized biological health indicator levels and/or deficiencies to provide required or recommended personalized medicaments (e.g. supplements, minerals, vitamins, pharmaceuticals, medicine, etc.) intended to address fluctuations in such levels/deficiencies, all within a same automated dispensing system and/or device.
  • required or recommended personalized medicaments e.g. supplements, minerals, vitamins, pharmaceuticals, medicine, etc.
  • a particular reader may contain an electronic board or the like operable to activate a camera to read the intensity of reagents on a strip, for example.
  • Other readers may alternatively use a nanotechnology chip or the like to determine the levels of particular biomarker readings in a bodily fluid (e.g.
  • the dispenser 300 is configured to dispense various vitamins and supplements provided in a discrete pebble format such that a quantifiable measure of these vitamins and supplements can be provided by counting a discrete number of each such pebbles being dispensed for a given personalized intake recommendation.
  • the dispenser generally comprises a cylindrical base portion 302 having an open cavity 304 formed in a front section thereof to receive a dispenser cup or receptacle (not shown).
  • a top of the base portion 302 is circumscribed by a sloping annular channel 306 that feeds into a chute 308 defined at its lowest point that opens into the cup- receiving cavity 304 such that any pebbles dropping into this channel 306 will be ultimately led to the chute 308 to be dispensed in a cup located in the cavity 304.
  • a front wall 310 and a back wall 312 are provided with mating engagement pegs/holes to connect in forming the cylindrical housing wall of the dispenser 300 about the bottom portion 302, an aperture 314 formed at a base of the front wall 310 shaped and sized to line up and thus provide access to the cavity 304.
  • the housing is fitted with a lid 316, which fits atop the housing walls 310/312.
  • respective containers 318 each having an independently actuated valve 320, are provided and held in place from the lid 316 to align with the annular channel 306 such that, upon actuating a given valve 320, a selected number of pebbles contained therein can be can be dropped into the annular channel and ultimately dispensed for intake.
  • a reader slot 322 is formed through the front wall 310 to lead to a corresponding biological strip reader (not shown) and downstream processing electronics (also not shown).
  • Other processing and communication hardware can be located within the housing and/or mounted in the base portion 302, for example.
  • a customer can refill the containers 318 using colour and/or shape-coded refillable containers and pebbles, or again using exchangeable containers that may themselves be colour and/or shape-coded to ensure recharge containers are loaded in the appropriate location in the dispenser so to maintain reproducible dispenser regimes without reconfiguring dispenser operational parameters.
  • rechargeable medicament storage containers may include a machine readable code, token or identifier that can be read and processed by the dispenser in confirming one or more attributes of the contained medicaments before being dispensed.
  • the rechargeable containers may include a type-specific identifier associated therewith, whereas the dispenser may further comprise respective type identifier readers operable to read each type identifier upon recharging each medicament storage container to automatically verify compatibility thereof.
  • container compatibility may be automatically assessed as a function of a source of the container or medicament contained therein, a type of the contained medicament and its correspondence with a designated medicament associated with a particular dispensing location in the dispenser, and/or a date (e.g.
  • Machine readable codes may take various forms, such as, but not limited to, barcodes, QR codes, RFID codes, encrypted tokens (e.g. NFC) and the like, with corresponding code readers and verification procedures integrated within the dispenser and/or remotely accessible from a system server or the like.
  • the dispenser 300 may track medicament quantities left in each container so to automatically alert the user when levels are low and a new order should be made to ensure the user does not experience any shortages in supply.
  • the dispenser may be further configured to automatically communicate medicament levels to a supply chain so to automatically order refills or recharge containers when levels reach a low supply threshold.
  • These automatic orders can be placed against a customer's preset purchase profile, payment options, and delivery details such that a refill package is automatically delivered to the user before stored supplies run out. This approach can drastically reduce the amount of friction and can involve human packaging or even robotic-based fulfillment to ensure quality control and cost-effective supply chain management.
  • the user could maintain the option to opt in or out of the auto-order function.
  • dispenser mechanisms may be considered to provide a similar solution.
  • an operable medicament container/pack selection, clamping and dumbing or delivery mechanism may be considered, whereby stacks of medicament containers/packs of known quantity/dose may be fed into the dispenser on respective insertion rails and selected for delivery in response to a particular user intake prescription.
  • Other mechanisms may also be considered, as will be readily appreciated by the skilled artisan.
  • the dispenser may further contain one or more enclosures, recesses and/or cavities to store disposable sample strips, dispenser cups, and the like.
  • Other features such as indicator lights, visible or audible user cues, or an integrated graphical user interface (e.g. power on/off, active wireless connection, data communication in progress, dispensing progress, status, user identifier, etc.) may also be considered without departing from the general scope and nature of the present disclosure.
  • rechargeable dispenser containers may be delivered pre-filled with designated medicaments in an organized box or container so to be easily extracted therefrom and recharged in the dispenser.
  • Useful accessories such as disposable dispenser cups, alcohol wipes, and or sample strips may also be included in sufficient quantities to accommodate the medicament quantities being delivered.
  • a fresh lot of medicaments may be pre-ordered for routine delivery, or again for delivery in response to an automated low-level order communication dispatched by the dispenser to a supply store, and packaged appropriately to preserve freshness (e.g. resealable bag, shrink wrapped, airtight container, etc.).
  • the dispenser may also be configured to support multiple users taking different sets of medicaments based on different health indicators and/or regimens.
  • multi-user configurations may include, but are not limited to, family or residence-based embodiments, but also community or commercially operable dispensers, for example operated within the context of a branded network of dispensers located within different establishments and communally operable by different registered users.
  • each user could be asked to create their own user profile, be it directly via a dispenser interface, a dedicated mobile application interface, and/or a Web interface to a system server communicatively accessible to the dispenser.
  • each user may input their age, sex, location and weight, for example, as well as other optional information such as prior medical history, family medical history and/or pre-existing issues (e.g. diabetes, etc.).
  • User access credentials such as username and password, and/or other user identification, authentication and authorization procedures (e.g. biometric login) may also be considered to enhance user access security and privacy.
  • respective dispensers may be ordered and used for different household users, and configured for stackable storage in minimizing its footprint. This option may be preferred where different users require drastically different medicament sets that exceed the capacity of a single dispenser.
  • different medicament storage and/or dispensing mechanisms may be stacked or otherwise configured while sharing certain electronic or communication resources, for example leveraging the functions of a joint sample reader and communication interface configured to recognized and communicate with each mechanical dispenser separately depending on the current user.
  • Other configuration considerations should also be considered to fall within the context of the present disclosure.
  • a dedicated application executed on the user's computing device could receive various data communications (as well as partake in some if not all data processing, software updates, and the like), and display various information to the user, such as dispenser content levels, performance, recent or upcoming orders, and dispensing history, to name a few.
  • the application can also display various historical readings to help track progress via trends or variations in monitored health indicators, which may be shown as graphs or tables, and optionally tracked against comparative data such as designated "healthy" indicator levels, variations or trends, or again against community or group data where various users within a same family, group or community are jointly tracked for collaborative and/or motivational purposes, for example.
  • Predictive timetables may also be optionally provided to estimate how long certain treatments may take in order to achieve "normalcy", for example.
  • FIG. 4 to 6 illustrate a mobile user registration and login process, whereby a registered user can enter their user name and password (and optionally other authentication details/biometrics), or invoke an account creation process (see Figure 4).
  • user credentials and correspondence information can be entered (see Figure 5), and basic user information entered (see Figure 6) to populate the user's profile.
  • the user can be guided through a user survey to provide further details as to the user's current wellbeing that can be used both to populate the user's profile and feed statistical user models and demographics, but also provide complementary information usable in the determination of a user-specific medicament intake regimen.
  • the user provides information on their quality of their sleep ( Figure 7), their dietary habits (Figure 8), medical and/or health history (Figure 9), fitness/exercise regiments (Figure 10), and/or mental health/mindset (Figure 11).
  • Each of these survey categories when taken alone or in various combinations, and optionally in combination with alternative user survey categories, may be taken into account in automatically outputting a personalized medicament intake regiment for the user, independently, or in combination with biological user sample readings and results as described above.
  • various home test kits may be ordered using the mobile application, for example, based on recommendations output by the application in response to the user survey responses, based on user interests and/or recommendations provided by a health care provider, to name a few examples. These orders may be directly relayed to appropriate distributers and/or remote bio sample testing establishments, and linked with associated electronic user payment portals (e.g. electronic credit card, mobile payment or other payment methods such as PayPalTM and the like) and delivery specification forms. Likewise, as shown in Figure 13, specific medicament orders may also be executed through the application, again, for example, based on automated system recommendations (e.g. biosample reader-based recommendations and/or user survey-based recommendations), external health practitioner recommendations, or again as a generic listing of available products/kits.
  • automated system recommendations e.g. biosample reader-based recommendations and/or user survey-based recommendations
  • external health practitioner recommendations e.g. biosample reader-based recommendations and/or user survey-based recommendations
  • Figure 14 illustrates an exemplary navigation menu allowing the user to migrate between portions of the application.
  • a wellness overview graph 1502 may highlight levels of certain vitamins, minerals and the like as measured by the user's latest biological reading. These current levels may feed into the system's recommended and colour coded intake regimen 1504. The user may also track comparative results 1506 between their own particular reading levels against corresponding community (e.g. based on geography, sex, age, etc.) levels, which in this example, are also tracked on a monthly basis showing seasonal trends. Finally, dispenser levels may also be accessed 1508, for instance, to allow user's to visualize when refills should be ordered and/or access a personal consumption rate. In this example, refill order buttons are also provided in various views to lead the user to a corresponding ordering form.
  • Figures 16 and 17 provide alternative dispenser level views, in accordance with different embodiments, wherein discrete refill buttons may displayed and linked to corresponding ordering forms, and/or where an auto-refill indicator may be selected to execute automated refill orders on behalf of the user upon a corresponding dispenser level reaching a particular user-defined or default refill threshold.
  • alerts may be invoked to alert the user that certain dispenser medicament levels have reached a certain threshold warranting refill.
  • Other alerts may be invoked to alert the user to take a known or new medicament, for example, based on a current or updated intake regiment, or again in response to a newly submitted biosample reading.
  • the user may be provided with the option to order this new medicament directly from the alert suggesting the intake of this new medicament.

Abstract

L'invention concerne divers modes de réalisation d'un système et d'un procédé personnalisés de distribution de médicaments, et un distributeur associé. Selon un mode de réalisation, un système personnalisé de distribution de médicament automatisé comprend : un processeur de dosage de médicament permettant d'évaluer automatiquement un indicateur numérique lié à la santé afin de délivrer en sortie un régime de prise personnalisé pour un médicament désigné prédéfini pour l'impact positif dudit indicateur lié à la santé ; une interface d'entrée numérique accessible par ledit processeur de dosage de médicament et recevant en entrée ledit indicateur numérique lié à la santé pour le traitement ; et un distributeur pouvant fonctionner en réponse à ladite sortie pour distribuer une dose à quantification discrète dudit médicament désigné selon ledit régime de prise personnalisé.
PCT/CA2017/050495 2016-04-21 2017-04-21 Système et procédé personnalisés de distribution de médicaments, et distributeur associé WO2017181287A1 (fr)

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WO2020053578A1 (fr) * 2018-09-10 2020-03-19 Hilton Eric Système d'analyse et d'administration
WO2021091693A1 (fr) * 2019-11-08 2021-05-14 Bristol-Myers Squibb Company Système pour vérifier la précision de modules de médicament connectés en série dans un dispositif d'administration de médicament combinatoire

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EP0301672A2 (fr) * 1987-07-31 1989-02-01 Aprex Corporation Distributeur de médicaments interactif
WO2013033033A1 (fr) * 2011-08-27 2013-03-07 Kraft Daniel L Distributeur de médicaments portable
WO2013040075A2 (fr) * 2011-09-12 2013-03-21 Dimartino Christopher J Distributeur de médicaments doté d'une fonction de communication électronique biométrique
WO2016012814A1 (fr) * 2014-07-24 2016-01-28 Intelligent Fingerprinting Limited Ensemble de distributeur de médicament

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Publication number Priority date Publication date Assignee Title
EP0301672A2 (fr) * 1987-07-31 1989-02-01 Aprex Corporation Distributeur de médicaments interactif
WO2013033033A1 (fr) * 2011-08-27 2013-03-07 Kraft Daniel L Distributeur de médicaments portable
WO2013040075A2 (fr) * 2011-09-12 2013-03-21 Dimartino Christopher J Distributeur de médicaments doté d'une fonction de communication électronique biométrique
WO2016012814A1 (fr) * 2014-07-24 2016-01-28 Intelligent Fingerprinting Limited Ensemble de distributeur de médicament

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020053578A1 (fr) * 2018-09-10 2020-03-19 Hilton Eric Système d'analyse et d'administration
US11532388B2 (en) 2018-09-10 2022-12-20 Eric Hilton Analysis and dispensing system
WO2021091693A1 (fr) * 2019-11-08 2021-05-14 Bristol-Myers Squibb Company Système pour vérifier la précision de modules de médicament connectés en série dans un dispositif d'administration de médicament combinatoire
US11844927B2 (en) 2019-11-08 2023-12-19 Bristol-Myers Squibb Company System for verifying accuracy of serially-connected drug modules in a combinatorial drug delivery device

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