WO2017179644A1 - 認知機能改善剤 - Google Patents
認知機能改善剤 Download PDFInfo
- Publication number
- WO2017179644A1 WO2017179644A1 PCT/JP2017/015084 JP2017015084W WO2017179644A1 WO 2017179644 A1 WO2017179644 A1 WO 2017179644A1 JP 2017015084 W JP2017015084 W JP 2017015084W WO 2017179644 A1 WO2017179644 A1 WO 2017179644A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vitamin
- cognitive function
- present
- dementia
- zinc
- Prior art date
Links
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- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 235000008924 yoghurt drink Nutrition 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
- 235000010930 zeaxanthin Nutrition 0.000 description 1
- 239000001775 zeaxanthin Substances 0.000 description 1
- 229940043269 zeaxanthin Drugs 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- OMSYGYSPFZQFFP-UHFFFAOYSA-J zinc pyrophosphate Chemical compound [Zn+2].[Zn+2].[O-]P([O-])(=O)OP([O-])([O-])=O OMSYGYSPFZQFFP-UHFFFAOYSA-J 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- AGFGXVAAIXIOFZ-UHFFFAOYSA-L zinc;butanedioate Chemical compound [Zn+2].[O-]C(=O)CCC([O-])=O AGFGXVAAIXIOFZ-UHFFFAOYSA-L 0.000 description 1
- RZFHLOLGZPDCHJ-XZXLULOTSA-N α-Tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C RZFHLOLGZPDCHJ-XZXLULOTSA-N 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000019145 α-tocotrienol Nutrition 0.000 description 1
- 239000011730 α-tocotrienol Substances 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 235000019151 β-tocotrienol Nutrition 0.000 description 1
- 239000011723 β-tocotrienol Substances 0.000 description 1
- FGYKUFVNYVMTAM-WAZJVIJMSA-N β-tocotrienol Chemical compound OC1=CC(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C FGYKUFVNYVMTAM-WAZJVIJMSA-N 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
- 235000019150 γ-tocotrienol Nutrition 0.000 description 1
- 239000011722 γ-tocotrienol Substances 0.000 description 1
- OTXNTMVVOOBZCV-WAZJVIJMSA-N γ-tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 OTXNTMVVOOBZCV-WAZJVIJMSA-N 0.000 description 1
- 239000002446 δ-tocopherol Substances 0.000 description 1
- 235000019144 δ-tocotrienol Nutrition 0.000 description 1
- 239000011729 δ-tocotrienol Substances 0.000 description 1
- ODADKLYLWWCHNB-LDYBVBFYSA-N δ-tocotrienol Chemical compound OC1=CC(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 ODADKLYLWWCHNB-LDYBVBFYSA-N 0.000 description 1
Classifications
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention relates to a cognitive function improving agent and a method for improving cognitive function.
- MCI Mild Cognitive Impairment
- MCI Mild Cognitive Impairment
- MCI is a symptom in the middle stage (gray zone) between dementia and healthy people, and there is a problem with one of cognitive functions (memory, decision, reasoning, execution, etc.) It means that there is no obstacle to daily life. It is said that if MCI is left unattended, cognitive function continues to decline, and about half of the stages progress to dementia. Because dementia is almost impossible to cure at this time, it is extremely important to provide appropriate prevention at the MCI stage to prevent progression of symptoms.
- Alzheimer-type dementia There are four types of dementia: Alzheimer-type dementia, Lewy body dementia, vascular dementia, and frontotemporal dementia.
- Alzheimer's disease is the most common dementia, accounting for more than half of dementia in old age. Alzheimer's disease is a disease characterized by progressive dementia that occurs from the early age to the old age. Currently, the number of patients in Japan is said to be over 3 million. Clinical symptoms of Alzheimer's disease include memory impairment, higher brain dysfunction (aphasia, agnosia, aphasia, constitutive aphasia, etc.). Alzheimer's disease is thought to be caused by the accumulation of amyloid ⁇ protein and tau protein in the brain, which causes neuronal cell death.
- ATP adenosine triphosphate
- ATP production declines year after year, and it is said that when 40 years old is 100, it is about 60% at 80 years old.
- Decreasing ATP levels promotes cognitive decline (ie, predisposition to developing dementia), but four anti-dementia drugs increase acetylcholine in the brain but cannot increase ATP levels.
- a cerebral circulation / metabolism improving agent can be used to promote ATP production, it currently has a drawback that it can be used only after an organic disorder such as cerebral infarction.
- Non-patent Document 1-5 it has been reported that a ginkgo biloba extract combined with phosphatidylserine may be used as an active ingredient of food or medicine for improving dementia and Alzheimer's disease.
- Patent Document 1-5 it has been reported that supplements containing vitamin B, vitamin C, vitamin E, ⁇ -carotene, folic acid, etc. alone or in combination (two to three types) are not effective in improving cognitive function.
- the object of the present invention is to provide a cognitive function improving agent having an effect of improving cognitive function, and a method for improving cognitive function.
- ATP production cannot be increased.
- ATP is produced through seven steps of the TCA cycle, but vitamins play an important role as coenzymes in each reaction. In other words, adequate supplementation with vitamins may promote ATP production.
- the present inventor has found that vitamin A, vitamin B group (B 1 , B 2 , B 6 and B 12 ), vitamin C, vitamin D, vitamin E, zinc, magnesium
- the present inventors have found that the above object can be achieved by a supplement containing pantothenic acid, biotin, and folic acid.
- the present invention has been completed through further studies based on these findings, and provides the following cognitive function improving agents and the like.
- Item 1 A cognitive function improving agent comprising vitamin A, vitamin B group (B 1 , B 2 , B 6 and B 12 ), vitamin C, vitamin D, vitamin E, zinc, magnesium, pantothenic acid, biotin, and folic acid as active ingredients.
- Item 2. Item 4. The cognitive function improving agent according to Item 1, wherein the content of vitamin D is 0.0008% by mass or more.
- Item 3. Item 3.
- the cognitive function improving agent according to Item 1 or 2 wherein the vitamin A content is 0.085% by mass or less.
- Item 4. Item 4.
- Cognition including the steps of administering vitamin A, vitamin B group (B 1 , B 2 , B 6 and B 12 ), vitamin C, vitamin D, vitamin E, zinc, magnesium, pantothenic acid, biotin, and folic acid to mammals How to improve functionality.
- the cognitive function improving agent of the present invention has an effect of improving the cognitive function of patients with MCI and dementia.
- the cognitive function improving agent of the present invention can be expected to be effective even when used alone, but it can be expected to effectively delay the progression of dementia and improve cognitive function when used in combination with an anti-dementia therapeutic agent. Furthermore, the cognitive function-improving agent of the present invention can be expected to maintain MDL and ADL (daily life movement) of patients with dementia.
- the cognitive function improving agent of the present invention contains vitamin A, vitamin B group (B 1 , B 2 , B 6 and B 12 ), vitamin C, vitamin D, vitamin E, zinc, magnesium, pantothenic acid, biotin, and folic acid. It is characterized by being (or containing) an active ingredient.
- Vitamin A in the present invention includes vitamin A 1 (retinol), retinal, retinoic acid, vitamin A 2 (3-dehydroretinol), 3-dehydroretinal, 3-dehydroretinoic acid, derivatives thereof, esters thereof, pro Vitamin A and salts thereof are included.
- Esters include esters with various fatty acids (such as retinol acetate), and provitamin A includes ⁇ -carotene, ⁇ -carotene, ⁇ -carotene, ⁇ -carotene, lycopene, zeaxanthin, ⁇ -cryptoxanthin, echinone, etc. Is mentioned.
- Vitamin A can be used alone or in combination of two or more. Vitamin A in the present invention can be used either isolated from a natural product or chemically synthesized.
- Vitamin B 1 in the present invention includes thiamine and its salts.
- the vitamin B 1 in the present invention any of those isolated from natural products and those chemically synthesized can be used.
- Vitamin B 2 in the present invention include riboflavin, and salts thereof. Vitamin B 2 in the present invention can be used either isolated from a natural product or chemically synthesized.
- Vitamin B 6 in the present invention includes pyridoxine, pyridoxal, pyridoxamine, salts thereof and the like. Vitamin B 6 may be used in combination of at least one kind alone or in combination. Vitamin B 6 in the present invention can be used either isolated from a natural product or chemically synthesized.
- Vitamin B 12 in the present invention include cobalamin, hydroxocobalamin, adenosyl cobalamin, methylcobalamin, cyanocobalamin, sulfite cobalamin, such as their salts. Vitamin B 12 may be used in combination of at least one kind alone or in combination. Vitamin B 12 in the present invention are those from natural products isolated, and any of those chemically synthesized may be used.
- Vitamin C in the present invention includes ascorbic acid and its salts. Vitamin C in the present invention can be used either isolated from a natural product or chemically synthesized.
- Vitamin D (calciferol) in the present invention includes vitamins D 2 to D 7 , provitamins D 2 to D 7 and salts thereof.
- Vitamin D in the present invention is preferably vitamin D 2 , vitamin D 3 , provitamin D 2 , and provitamin D 3 .
- Vitamin D can be used alone or in combination of two or more.
- any of those isolated from natural products and those chemically synthesized can be used.
- Vitamin E in the present invention includes ⁇ -tocopherol, ⁇ -tocopherol, ⁇ -tocopherol, ⁇ -tocopherol, ⁇ -tocopherol, ⁇ -tocotrienol, ⁇ -tocotrienol, ⁇ -tocotrienol, and salts thereof. Vitamin E can be used alone or in combination of two or more. Vitamin E in the present invention can be used either isolated from a natural product or chemically synthesized.
- the magnesium in the present invention includes magnesium, its salt and the like.
- the magnesium salt include magnesium oxide, magnesium chloride, magnesium carbonate, magnesium sulfate and the like.
- Magnesium can be used alone or in combination of two or more. Magnesium in the present invention can be used either isolated from a natural product or chemically synthesized.
- the zinc in the present invention includes zinc, a salt thereof and the like.
- the organic acid salt of zinc include zinc pyrophosphate, zinc citrate, zinc succinate, and zinc gluconate.
- Examples of the inorganic acid salt of zinc include zinc chloride and zinc sulfate.
- Zinc can be used alone or in combination of two or more.
- the zinc in the present invention either one isolated from a natural product or one chemically synthesized can be used.
- the zinc in this invention can use the raw material containing zinc, such as zinc yeast and oysters, as it is or roughly refined.
- pantothenic acid in the present invention includes pantothenic acid and its salt.
- pantothenic acid in the present invention either one isolated from a natural product or one chemically synthesized can be used.
- the biotin in the present invention includes biotin, a salt thereof and the like.
- biotin in the present invention either biotin isolated from natural products or chemically synthesized can be used.
- a raw material containing biotin such as biotin-containing yeast can be used as it is or roughly.
- the folic acid in the present invention includes folic acid, folic acid derivatives, salts thereof and the like.
- the folic acid in the present invention can be used either isolated from a natural product or chemically synthesized.
- Vitamin A vitamin B group (B 1 , B 2 , B 6 and B 12 ), vitamin C, vitamin D, vitamin E, zinc, magnesium, pantothenic acid, biotin, and folic acid in the cognitive function inhibitor of the present invention
- the content is not particularly limited, and for example, the content of each active ingredient can be set so as to be the daily intake per adult described later.
- the content of vitamin A in the cognitive function improving agent of the present invention is not particularly limited and is preferably 0.00001% by mass or more, more preferably 0.0001% by mass or more, preferably 0.085% by mass or less, more preferably 0.0085% by mass. It is as follows.
- the content of vitamin D in the cognitive function improving agent of the present invention is not particularly limited, and is preferably 0.0008% by mass or more, more preferably 0.0010% by mass or more, preferably 0.0068% by mass or less, more preferably 0.0021% by mass. It is as follows.
- the content of zinc in the cognitive function improving agent of the present invention is not particularly limited, preferably 0.0001% by mass or more, more preferably 0.001% by mass or more, preferably 0.35% by mass or less, more preferably 0.28% by mass or less. It is.
- Cognitive function improving agent of the present invention is a pharmaceutical, quasi-drug, and food and drink (e.g., health food, nutritional composition, nutritional supplement, functional food, nutritional supplement, supplement, health food) , Foods for specified health use, nutritional functional foods, functional labeling foods, etc.). Moreover, the cognitive function improving agent of the present invention also includes the meaning of the additive that imparts the cognitive function improving action.
- the above-mentioned food and drink as necessary, minerals, vitamins, flavonoids, quinones, polyphenols, amino acids, nucleic acids, essential fatty acids, enzymes, starch, Edible fats and oils, sweeteners, acidulants, bittering agents, seasonings, coloring agents, flavoring agents, preservatives, bleaching agents, manufacturing agents, cooling agents, thickeners, emulsifiers, stabilizers, preservatives, swelling agents, interfaces
- Activators, binders, solubilizers, wetting agents, excipients, lubricants, binders, disintegrants, antioxidants, pH adjusters, brighteners, gum bases, and the like can be blended.
- the types of foods and drinks described above include all foods and drinks that can be consumed by mammals (including humans), such as dairy products; fermented foods (yogurt, cheese, etc.); beverages (coffee, juice, cocoa, tea) Beverages, sports drinks, soft drinks such as nutrition drinks, milk drinks, lactic acid bacteria drinks, drinks containing lactic acid bacteria, yogurt drinks, carbonated drinks, sakes such as sake, western liquor, fruit liquor); spreads (such as custard cream); Pastes (fruit paste, etc.); Western confectionery (chocolate, donut, pie, cream puff, gum, gummy, jelly, candy, cookie, cake, pudding, biscuits, etc.); Yokan, rice crackers, rice crackers, rice cakes, etc.) Ice confectionery (ice cream, popsicle, sherbet, etc.); Foods (curry, beef bowl, miscellaneous goods) , Miso soup, soup, meat sauce, pasta, pickles, jam, ham, sausage, bacon, etc.); seasonings (dressing, sprinkle, umami
- the dosage unit form for use as a supplement or the like is not particularly limited and can be appropriately selected.
- tablets for example, plain tablets, sugar-coated tablets, film-coated tablets, chewable tablets, troche tablets, etc.
- capsules fine granules, Granules, liquids, powders, syrups, pastes, drinks and the like can be mentioned.
- the production method of the above food and drink is not particularly limited, and a known method can be appropriately followed.
- the intake of the cognitive function improving agent of the present invention can be appropriately set according to various conditions such as the body weight, age, sex, and symptoms of the user.
- the intake amount of each active ingredient of the cognitive function improving agent of the present invention per day for an adult is not particularly limited, and examples thereof include the following vitamin A: preferably 50 to 3,000 ⁇ g, more preferably 50 to 300 ⁇ g.
- Vitamin B 1 preferably 25 to 200 mg, more preferably 50 to 150 mg Vitamin B 2 : preferably 10-100 mg, more preferably 20-60 mg Vitamin B 6 : preferably 10-100 mg, more preferably 20-60 mg Vitamin B 12 : preferably 100 to 1,500 ⁇ g, more preferably 450 to 1,000 ⁇ g Vitamin C: preferably 100 to 5,000 mg, more preferably 1,000 to 3,000 mg Vitamin D: preferably 5 to 250 ⁇ g, more preferably 10 to 75 ⁇ g Vitamin E: preferably 50 to 800 mg, more preferably 67 to 400 mg Zinc: preferably 2-12 mg, more preferably 3-10 mg Magnesium: preferably 5 to 100 mg, more preferably 10 to 80 mg Pantothenic acid: preferably 50 to 400 mg, more preferably 120 to 300 mg Biotin: preferably 50 to 500 ⁇ g, more preferably 150 to 450 ⁇ g Folic acid: preferably 100-1,500 ⁇ g, more preferably 450-1,200 ⁇ g
- the active ingredient is combined with a non-toxic carrier, diluent or excipient acceptable in the pharmaceutical product as a tablet (plain tablet, sugar-coated tablet, (Including effervescent tablets, film-coated tablets, chewable tablets, troches, etc.), capsules, pills, powders (powder), fine granules, granules, solutions, suspensions, emulsions, syrups, pastes, It can be prepared in the form of an injection (including a case where it is mixed with an infusion such as distilled water or an amino acid infusion or an electrolyte infusion when used to prepare it as a liquid) to form a pharmaceutical preparation.
- a tablet plain tablet, sugar-coated tablet, (Including effervescent tablets, film-coated tablets, chewable tablets, troches, etc.), capsules, pills, powders (powder), fine granules, granules, solutions, suspensions, emulsions, syrups, pastes.
- the administration method of the above quasi-drug or pharmaceutical is not particularly limited, and can be performed by, for example, intraarterial administration, intravenous administration, buccal administration, rectal administration, enteral administration, transdermal administration, oral administration, and the like. .
- the dose of the quasi-drug or pharmaceutical product can be appropriately determined according to various conditions such as the patient's weight, age, sex, and symptoms, and each cognitive function improving agent of the present invention per adult can be determined.
- the dose of the active ingredient is not particularly limited, and examples thereof include those described above. *
- the cognitive function improving agent of the present invention comprises vitamin A, vitamin B group (B 1 , B 2 , B 6 and B 12 ), vitamin C, vitamin D, vitamin E, zinc, magnesium, pantothenic acid, biotin, and folic acid.
- the cognitive function improving agent of the present invention is used for the purpose of improving cognitive function.
- cognitive function means a function in which a disorder is observed in dementia.
- cognitive functions include memory, attention, language functions, functions to perform a series of movements that have been acquired, functions to grasp the surrounding situation through the five senses, performance functions, and orientation.
- “Dementia” is a state in which intelligence once developed normally is irreversibly lowered due to an acquired organic disorder of the brain.
- “improvement” includes prevention of further deterioration of symptoms, that is, maintenance.
- the subject of application of the cognitive function improving agent of the present invention includes patients with dementia (particularly Alzheimer's disease), patients with MCI, patients with pre-MCI, etc. Elderly people who do not have any problems are also included in the target audience.
- the cognitive function improving agent of the present invention is applied to mammals including humans.
- the cognitive function-improving agent of the present invention can be expected to be effective even when used alone, but it effectively delays the progression of dementia when used in combination with an anti-dementia drug (donepezil, memantine, galantamine, rivastigmine, etc.) Functional improvement can be expected. Furthermore, the cognitive function-improving agent of the present invention can be expected to maintain MDL and ADL (daily life movement) of patients with dementia.
- the test for cognitive function improving agent of the present invention was conducted in 10 test examples .
- 7 were subjective forgetfulness and easy-fatigue pre-MCI patients, and 3 cases (No2, No3, No10) were subjective forgetfulness and easy-fatigue .
- the patient was also diagnosed with Pre-MCI, MCI, or dementia on 1 and imaging.
- Pre-MCI Pre-MCI
- MCI MCI
- dementia dementia
- capsules having the compositions shown in Table 1 below were administered to the subjects. * 1
- the MMSE test is widely used worldwide as a screening test for dementia. It consists of 11 questions and 30 points when all questions are answered correctly.
- each subject received a doctor's examination or interview before administration of the capsule and after administration for a certain period.
Abstract
Description
項2.ビタミンDの含有量が0.0008質量%以上である、項1に記載の認知機能改善剤。
項3.ビタミンAの含有量が0.085質量%以下である、項1又は2に記載の認知機能改善剤。
項4.亜鉛の含有量が0.35質量%以下である、項1~3のいずれか一項に記載の認知機能改善剤。
項5.認知機能改善剤(認知機能改善用保健用食品)の製造における、ビタミンA、ビタミンB群(B1、B2、B6及びB12)、ビタミンC、ビタミンD、ビタミンE、亜鉛、マグネシウム、パントテン酸、ビオチン、並びに葉酸の使用。
項6.ビタミンA、ビタミンB群(B1、B2、B6及びB12)、ビタミンC、ビタミンD、ビタミンE、亜鉛、マグネシウム、パントテン酸、ビオチン、並びに葉酸を哺乳動物に投与する工程を含む認知機能を改善する方法。
項7.ビタミンA、ビタミンB群(B1、B2、B6及びB12)、ビタミンC、ビタミンD、ビタミンE、亜鉛、マグネシウム、パントテン酸、ビオチン、並びに葉酸を含む認知機能改善用組成物。
ビタミンA:好ましくは50~3,000μg、より好ましくは50~300μg
ビタミンB1:好ましくは25~200 mg、より好ましくは50~150 mg
ビタミンB2:好ましくは10~100 mg、より好ましくは20~60 mg
ビタミンB6:好ましくは10~100 mg、より好ましくは20~60 mg
ビタミンB12:好ましくは100~1,500μg、より好ましくは450~1,000μg
ビタミンC:好ましくは100~5,000 mg、より好ましくは1,000~3,000 mg
ビタミンD:好ましくは5~250μg、より好ましくは10~75μg
ビタミンE:好ましくは50~800 mg、より好ましくは67~400 mg
亜鉛:好ましくは2~12 mg、より好ましくは3~10 mg
マグネシウム:好ましくは5~100 mg、より好ましくは10~80 mg
パントテン酸:好ましくは50~400 mg、より好ましくは120~300 mg
ビオチン:好ましくは50~500μg、より好ましくは150~450μg
葉酸:好ましくは100~1,500μg、より好ましくは450~1,200μg
10症例で本発明の認知機能改善剤について試験を行った。試験例10例のうち、7症例は自覚的な物忘れ及び易疲労性のPre-MCI患者であり、3症例(No2, No3, No10)については自覚的物忘れ及び易疲労性があり、MMSE検査*1及び画像診断上もPre-MCI, MCI又は認知症と診断された患者であった。これら10症例は大量ビタミン投与に同意を得た上で所定のビタミン量を投与し経過を観察した。具体的には、以下の表1に示す組成のカプセル剤を被験者に投与した。
*1 MMSE検査とは、認知症のスクリーニングテストとして世界的に広く用いられているものであり、11項目の質問事項からなり、全問正解すると30点である。
Claims (5)
- ビタミンA、ビタミンB群(B1、B2、B6及びB12)、ビタミンC、ビタミンD、ビタミンE、亜鉛、マグネシウム、パントテン酸、ビオチン、並びに葉酸を有効成分とする認知機能改善剤。
- ビタミンDの含有量が0.0008質量%以上である、請求項1に記載の認知機能改善剤。
- ビタミンAの含有量が0.085質量%以下である、請求項1又は2に記載の認知機能改善剤。
- 亜鉛の含有量が0.35質量%以下である、請求項1~3のいずれか一項に記載の認知機能改善剤。
- ビタミンA、ビタミンB群(B1、B2、B6及びB12)、ビタミンC、ビタミンD、ビタミンE、亜鉛、マグネシウム、パントテン酸、ビオチン、並びに葉酸を哺乳動物に投与する工程を含む認知機能を改善する方法。
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US16/090,843 US10695369B2 (en) | 2016-04-15 | 2017-04-13 | Cognitive function-remedying agent |
CN201780023085.7A CN109069534B (zh) | 2016-04-15 | 2017-04-13 | 认知功能改善剂 |
JP2018512057A JP6923940B2 (ja) | 2016-04-15 | 2017-04-13 | 認知機能改善剤 |
EP17782457.0A EP3443965A4 (en) | 2016-04-15 | 2017-04-13 | MEANS FOR HEALING THE COGNITIVE FUNCTION |
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EP (1) | EP3443965A4 (ja) |
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KR102275981B1 (ko) * | 2020-03-31 | 2021-07-13 | 고려은단주식회사 | 섬쑥부쟁이 추출물과 비타민 b 복합체의 혼합물을 포함하는 인지기능 개선용 조성물 |
EP3981407A1 (de) | 2020-10-07 | 2022-04-13 | WÖRWAG Pharma GmbH & Co.KG | Biofaktoren zur behandlung und prophylaxe von demenz |
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KR102582570B1 (ko) | 2021-03-19 | 2023-09-22 | 한국생명공학연구원 | 유박테리움 칼란데리, 이의 배양액 또는 이의 배양액 추출물을 유효성분으로 포함하는 암 예방 또는 치료용 조성물 |
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DE202014102551U1 (de) | 2014-05-30 | 2015-02-26 | Orthomol Pharmazeutische Vertriebs Gmbh | Diätetische Zubereitung in Form eines Riegels |
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JP2009532496A (ja) * | 2006-04-03 | 2009-09-10 | アクセラ・インコーポレーテッド | 加齢に伴う記憶障害を治療するためのケト原性化合物の使用 |
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KR102275981B1 (ko) * | 2020-03-31 | 2021-07-13 | 고려은단주식회사 | 섬쑥부쟁이 추출물과 비타민 b 복합체의 혼합물을 포함하는 인지기능 개선용 조성물 |
EP3981407A1 (de) | 2020-10-07 | 2022-04-13 | WÖRWAG Pharma GmbH & Co.KG | Biofaktoren zur behandlung und prophylaxe von demenz |
WO2022074114A1 (de) | 2020-10-07 | 2022-04-14 | Wörwag Pharma GmbH & Co.KG | Biofaktoren zur behandlung und prophylaxe von demenz |
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CN109069534B (zh) | 2021-04-20 |
US20190117687A1 (en) | 2019-04-25 |
EP3443965A4 (en) | 2020-02-19 |
CN109069534A (zh) | 2018-12-21 |
JP6923940B2 (ja) | 2021-08-25 |
TW201737904A (zh) | 2017-11-01 |
JPWO2017179644A1 (ja) | 2019-02-21 |
EP3443965A1 (en) | 2019-02-20 |
US10695369B2 (en) | 2020-06-30 |
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